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<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="8EQI1aIA0VufgdRiZjGeYzxITV5OphxzRTj5ToUPACS-tx8b7cjh-W0zVsX9lsEgbFsST7XuSoGsuYnSt2lAOQ" /> <meta name="citation_title" content="Tissue engineering in oral and maxillofacial reconstruction" /> <meta name="citation_author" content="nevein shawkey" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/29349678/Tissue_engineering_in_oral_and_maxillofacial_reconstruction" /> <meta name="twitter:title" content="Tissue engineering in oral and maxillofacial reconstruction" /> <meta name="twitter:description" content="The artificial generation of tissues, organs, or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical" /> <meta name="twitter:image" content="https://0.academia-photos.com/55435786/112612869/101877283/s200_nevein.shawkey.png" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/29349678/Tissue_engineering_in_oral_and_maxillofacial_reconstruction" /> <meta property="og:title" content="Tissue engineering in oral and maxillofacial reconstruction" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="The artificial generation of tissues, organs, or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical" /> <meta property="article:author" content="https://independent.academia.edu/neveinshawkey" /> <meta name="description" content="The artificial generation of tissues, organs, or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical" /> <title>(PDF) Tissue engineering in oral and maxillofacial reconstruction</title> <link rel="canonical" href="https://www.academia.edu/37980165/Tissue_engineering_in_oral_and_maxillofacial_reconstruction" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'b092bf3a3df71cf13feee7c143e83a57eb6b94fb'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1739827571000); window.Aedu.timeDifference = new Date().getTime() - 1739827571000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"The artificial generation of tissues, organs, or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical medicine. The interest and attention that this rapidly developing area has received are based on the vision that the growing understanding of tissue healing and the achievements of biotechnology will be of profound therapeutic relevance. Clinically, reconstructive surgery has arrived at a standard of care that allows for repair and restoration of the vast majority of tissues/organs with established techniques. The real challenge of tissue engineering in clinical treatment is the reduction of surgical morbidity by the application of biological signals or bio-artificial components cultivated from the patient\u0026amp;#39;s own cells, that can replace the lost body part or accomplish its repair without the need for autogenous tissue transfer. Initially, activities in this area were mainly focused on cell-based approaches aiming at the generation of tissue-like constructs by combining ex vivo expanded cell populations with various types of scaffolds. Today, the field of tissue engineering has expanded tremendously, in that not only cells and scaffolds but also growth factors, controlled release carriers, engineering of biomaterials and many other areas of basic and applied research are considered to be part of the field of tissue engineering.","author":[{"@context":"https://schema.org","@type":"Person","name":"nevein shawkey","url":"https://independent.academia.edu/neveinshawkey"}],"contributor":[],"dateCreated":"2016-10-22","dateModified":"2024-11-28","headline":"Tissue engineering in oral and maxillofacial 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{"work":{"id":29349678,"created_at":"2016-10-22T10:39:56.612-07:00","from_world_paper_id":null,"updated_at":"2024-11-28T07:07:52.883-08:00","_data":{"abstract":"The artificial generation of tissues, organs, or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical medicine. The interest and attention that this rapidly developing area has received are based on the vision that the growing understanding of tissue healing and the achievements of biotechnology will be of profound therapeutic relevance. Clinically, reconstructive surgery has arrived at a standard of care that allows for repair and restoration of the vast majority of tissues/organs with established techniques. The real challenge of tissue engineering in clinical treatment is the reduction of surgical morbidity by the application of biological signals or bio-artificial components cultivated from the patient's own cells, that can replace the lost body part or accomplish its repair without the need for autogenous tissue transfer. Initially, activities in this area were mainly focused on cell-based approaches aiming at the generation of tissue-like constructs by combining ex vivo expanded cell populations with various types of scaffolds. Today, the field of tissue engineering has expanded tremendously, in that not only cells and scaffolds but also growth factors, controlled release carriers, engineering of biomaterials and many other areas of basic and applied research are considered to be part of the field of tissue engineering.","ai_title_tag":"Advancements in Tissue Engineering for Maxillofacial Surgery"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Tissue engineering in oral and maxillofacial reconstruction","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [55435786]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; 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const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=29349678"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">The artificial generation of tissues, organs, or even more complex living organisms was throughout the history of mankind a matter of myth and dream. During the last decades this vision became feasible and has been recently introduced in clinical medicine. The interest and attention that this rapidly developing area has received are based on the vision that the growing understanding of tissue healing and the achievements of biotechnology will be of profound therapeutic relevance. Clinically, reconstructive surgery has arrived at a standard of care that allows for repair and restoration of the vast majority of tissues/organs with established techniques. The real challenge of tissue engineering in clinical treatment is the reduction of surgical morbidity by the application of biological signals or bio-artificial components cultivated from the patient's own cells, that can replace the lost body part or accomplish its repair without the need for autogenous tissue transfer. Initially, activities in this area were mainly focused on cell-based approaches aiming at the generation of tissue-like constructs by combining ex vivo expanded cell populations with various types of scaffolds. Today, the field of tissue engineering has expanded tremendously, in that not only cells and scaffolds but also growth factors, controlled release carriers, engineering of biomaterials and many other areas of basic and applied research are considered to be part of the field of tissue engineering.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":49790849,"attachmentType":"pdf","workUrl":"https://www.academia.edu/29349678/Tissue_engineering_in_oral_and_maxillofacial_reconstruction"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":49790849,"attachmentType":"pdf","workUrl":"https://www.academia.edu/29349678/Tissue_engineering_in_oral_and_maxillofacial_reconstruction"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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It offers a new option to supplement existing treatment regimens for reconstruction/regeneration of the oral and craniofacial complex, which includes the teeth, periodontium, bones, soft tissues (oral mucosa, conjunctiva, skin), salivary glands, and the temporomandibular joint (bone and cartilage), as well as blood vessels, muscles, tendons, and nerves. Tissue engineering is based on harvesting the stem cells which are having potential to form an organ. Harvested cells are then transferred into scaffolds that are manufactured in a laboratory to resemble the structure of the desired tissue to be replaced. This article reviews the principles of tissue engineering and its various applications in oral and maxillofacial surgery.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering: Step Ahead in Maxillofacial Reconstruction","attachmentId":83303022,"attachmentType":"pdf","work_url":"https://www.academia.edu/75597700/Tissue_Engineering_Step_Ahead_in_Maxillofacial_Reconstruction","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/75597700/Tissue_Engineering_Step_Ahead_in_Maxillofacial_Reconstruction"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="72119148" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72119148/Role_of_tissue_engineering_in_oral_and_maxillofacial_surgery_a_review">Role of tissue engineering in oral & maxillofacial surgery – a review</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="162615081" href="https://independent.academia.edu/SaravananBalasubramaniam2">Saravanan Balasubramaniam</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Medical Research and Review, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Tissue engineering can be defined as the "reconstitution of tissue and organs, in vitro for use as model systems in basic and applied research, or for use as grafts to replace damaged or diseased body parts or body functions". Biomaterials have been used as replacement tissues and grafts have been used to reconstruct defects in craniofacial region till Uristmade the first attempt of producing exogenous bone with the help of bone morphogenetic proteins. The success of tissue engineering over the field of all transplantation is that conceptually a three-dimensional functional tissue is designed. This field has become a boon to the Cranio Maxillofacial surgeons and has provided them with a supplement to existing treatment for reconstruction of Oral & Craniofacial region. The purpose of this article is to present an overview of the various uses of tissue engineering in the field of Oral and Maxillofacial Surgery.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of tissue engineering in oral \u0026 maxillofacial surgery – a review","attachmentId":81177057,"attachmentType":"pdf","work_url":"https://www.academia.edu/72119148/Role_of_tissue_engineering_in_oral_and_maxillofacial_surgery_a_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/72119148/Role_of_tissue_engineering_in_oral_and_maxillofacial_surgery_a_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="69015979" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/69015979/Clinical_Functions_of_Regenerative_Dentistry_and_Tissue_Engineering_in_Treatment_of_Oral_and_Maxillofacial_Soft_Tissues">Clinical Functions of Regenerative Dentistry and Tissue Engineering in Treatment of Oral and Maxillofacial Soft Tissues</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="127606212" href="https://independent.academia.edu/mohammadrezajamalpour">mohammad reza jamalpour</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2019</p><p class="ds-related-work--abstract ds2-5-body-sm">Recent advancements in tissue engineering have created many promising innovative possibilities for oral and maxillofacial soft tissue reconstruction. Developments in tissue and organ 3D printing reconstruction technology have been made possible through the use of scaffolds that are highly specific and closely related to affected oral and maxillofacial areas. These developments have allowed for a significant evolution in tissue engineering. The most important characteristics of this method are the avoidance of secondary surgeries post-graft preparation, unrestricted amount of tissue augmentation, and the utilization of precisely designed scaffolds that mimic the damaged tissue. Said engineered structures are composed of either natural or synthetic materials, which can be combined with the recipient’s stem cells. Although many in vivo and in vitro studies have been conducted on the mechanisms and results of this method, which proves its efficiency, further studies are required to inve...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Clinical Functions of Regenerative Dentistry and Tissue Engineering in Treatment of Oral and Maxillofacial Soft Tissues","attachmentId":79277629,"attachmentType":"pdf","work_url":"https://www.academia.edu/69015979/Clinical_Functions_of_Regenerative_Dentistry_and_Tissue_Engineering_in_Treatment_of_Oral_and_Maxillofacial_Soft_Tissues","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/69015979/Clinical_Functions_of_Regenerative_Dentistry_and_Tissue_Engineering_in_Treatment_of_Oral_and_Maxillofacial_Soft_Tissues"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="49488503" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/49488503/Tissue_engineering_the_promise_of_regenerative_dentistry">Tissue engineering - the promise of regenerative dentistry</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="93939317" href="https://independent.academia.edu/MukhtarAndrabi">Mukhtar Andrabi</a></div><p class="ds-related-work--abstract ds2-5-body-sm">The science of tissue engineering aims at the repair of damaged tissues as well as creates replacement of the lost ones. This is becoming a major component of the regenerative medicine by combining the principles of transplantation, materials science and bioengineering to restore a diseased or a damaged tissue to normal function. The earliest attempts at tissue replacement thousands of years back involved teeth and even in modern times, dentistry has continued to place considerable emphasis on the study and use of biocompatible materials. For most of the general dental practitioners restoration of lost tooth tissue, whether from disease or trauma, represents a significant proportion of their daily routine. Considering the current prevalence of the dental diseases, it can be said that the challenge and resource burden of restoring lost tooth tissue will be with us for many years to come. Tissue engineering will have a considerable effect on dental practice during the next coming years. The greatest effects will likely be related to the repair and replacement of mineralized tissues, the promotion of oral wound healing, correction of craniofacial abnormalities, integration of biocompatible prosthetic implant materials with the oral tissues, the regeneration of dental hard and soft tissues and the use of gene transfer adjunctively. The purpose of this brief review is to provide the general dental practitioner a background of tissue engineering, its accomplishments in dentistry and its future promises to the profession in the form of regenerative dentistry.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue engineering - the promise of regenerative dentistry","attachmentId":67829068,"attachmentType":"pdf","work_url":"https://www.academia.edu/49488503/Tissue_engineering_the_promise_of_regenerative_dentistry","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/49488503/Tissue_engineering_the_promise_of_regenerative_dentistry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="73019927" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/73019927/Review_Article_Today_Prospects_for_Tissue_Engineering_Therapeutic_Approach_in_Dentistry">Review Article Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="36097573" href="https://independent.academia.edu/DanieleCarbone1">Daniele Carbone</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2016</p><p class="ds-related-work--abstract ds2-5-body-sm">Copyright © 2014 Maurizio Bossu ̀ et al.This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In dental practice there is an increasing need for predictable therapeutic protocols able to regenerate tissues that, due to inflammatory or traumatic events, may suffer from loss of their function. One of the topics arising major interest in the research applied to regenerative medicine is represented by tissue engineering and, in particular, by stem cells. The study of stem cells in dentistry over the years has shown an exponential increase in literature. Adult mesenchymal stem cells have recently been isolated and characterized from tooth-related tissues and they might represent, in the near future, a new gold standard in the regeneration of all oral tissues. The aim of our review is to provide an overview on the topic reporting t...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Review Article Today Prospects for Tissue Engineering Therapeutic Approach in Dentistry","attachmentId":81708243,"attachmentType":"pdf","work_url":"https://www.academia.edu/73019927/Review_Article_Today_Prospects_for_Tissue_Engineering_Therapeutic_Approach_in_Dentistry","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/73019927/Review_Article_Today_Prospects_for_Tissue_Engineering_Therapeutic_Approach_in_Dentistry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="71587013" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/71587013/Biotechnology_of_Tissues_and_Materials_in_Dentistry_Future_Prospects">Biotechnology of Tissues and Materials in Dentistry — Future Prospects</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="92751650" href="https://independent.academia.edu/Andr%C3%A9aCristinaBarbosadaSilva">Andréa Cristina Barbosa da Silva</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Current Concepts in Dental Implantology, 2015</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Biotechnology of Tissues and Materials in Dentistry — Future Prospects","attachmentId":80866811,"attachmentType":"pdf","work_url":"https://www.academia.edu/71587013/Biotechnology_of_Tissues_and_Materials_in_Dentistry_Future_Prospects","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/71587013/Biotechnology_of_Tissues_and_Materials_in_Dentistry_Future_Prospects"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="71473076" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/71473076/Tissue_Engineering_Applications_in_Maxillofacial_Surgery">Tissue Engineering Applications in Maxillofacial Surgery</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50051745" href="https://myulg.academia.edu/MohammadHosseinKhosraviMD">Mohammad Hossein Khosravi, M.D.</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Stem Cells in Clinical Practice and Tissue Engineering, 2018</p><p class="ds-related-work--abstract ds2-5-body-sm">Nowadays, oral and maxillofacial surgeons face serious difficulties in reconstruction of large defects caused by trauma, cancer, or congenital deformities. Considering each part of oral and maxillofacial region consisting of several tissues, it is necessary to reconstruct these architectures layer by layer. Through years surgeons use different forms of grafts to reconstruct these defects. As these grafts and techniques are well described and used routinely, it should have been noticed that they are not without complications. This is where idea behind tissue engineering steps in. "Tissue engineering" due to its multi-aspect properties can be defined as application of methods and science of engineering toward the understanding of structure-function relationships of mammalian tissues in both normal and pathological forms to improve and develop biologic substitutes to reach the main goal of restoring, maintaining, and stabilization of tissue function. From standpoint of surgery, tissue engineering is not considered as a potential step anymore, but as an available approach to reach the ultimate goal of reconstruction procedures. The aim of this chapter is to defne concepts and advances in tissue engineering (TE). Also, review TE applications in the field of oral and maxillofacial surgery with bolding its clinical applications and complications based on novel and high-quality published researches.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering Applications in Maxillofacial Surgery","attachmentId":80799901,"attachmentType":"pdf","work_url":"https://www.academia.edu/71473076/Tissue_Engineering_Applications_in_Maxillofacial_Surgery","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/71473076/Tissue_Engineering_Applications_in_Maxillofacial_Surgery"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="26643360" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/26643360/Current_strategies_and_applications_of_tissue_engineering_in_dentistry_a_review_part_1">Current strategies and applications of tissue engineering in dentistry--a review part 1</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50630214" href="https://independent.academia.edu/NeerajMalhotra4">Neeraj Malhotra</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Dental update, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">A new direction in the field of vital pulp therapy is given by the introduction of tissue engineering as an emerging science. It aims to regenerate a functional tooth-tissue structure by the interplay of three basic key elements: stem cells, morphogens and scaffolds. It is a multidisciplinary approach that combines the principles of biology, medicine, and engineering to repair and/or regenerate a damaged tissue and/or organ. This two part article reviews and discusses the basic concept and strategies so far studied and researched for the engineering of basic dental tissues, to restore a functional tooth anatomy. This first part focuses on a detailed description of key elements used in tissue engineering and their applied clinical applications in dentistry. The second part will deal with the strategies that are being used and/or developed to regenerate the tooth tissues with the help of this scientific principle. The field of tissue engineering has recently shown promising results an...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Current strategies and applications of tissue engineering in dentistry--a review part 1","attachmentId":46927602,"attachmentType":"pdf","work_url":"https://www.academia.edu/26643360/Current_strategies_and_applications_of_tissue_engineering_in_dentistry_a_review_part_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/26643360/Current_strategies_and_applications_of_tissue_engineering_in_dentistry_a_review_part_1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="100418037" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/100418037/Tissue_Engineering_in_Oral_and_Maxillofacial_Surgery">Tissue Engineering in Oral & Maxillofacial Surgery</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="254432053" href="https://independent.academia.edu/upasanasethi2">upasana sethi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Medical and Dental Sciences, 2012</p><p class="ds-related-work--abstract ds2-5-body-sm">A recent innovation in dentistry is the preparation and use of platelet rich plasma, a concentration of platelets and growth factors found in platelets. These polypeptide growth factors as well as other bioactive substances are released from platelets upon activation, which play a pivotal role in initiating and sustaining wound healing and tissue repair mechanism. In order to improve wound healing and bone regeneration, attempts were made to increase the concentration of wound healing initiating factors in the form of platelet concentrate. Platelet derived polypeptide growth factors as well as other bioactive substances are released from platelet upon activation which plays a pivotal role in initiating and sustaining wound healing and tissue repair mechanism. This article is an attempt to highlight the uses of Platelet rich plasma (PRP) in Oral & Maxillofacial Surgery and the preparation of PRP gel in the immediate preoperative period in a laboratory centrifuge.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Tissue Engineering in Oral \u0026 Maxillofacial Surgery","attachmentId":101247876,"attachmentType":"pdf","work_url":"https://www.academia.edu/100418037/Tissue_Engineering_in_Oral_and_Maxillofacial_Surgery","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/100418037/Tissue_Engineering_in_Oral_and_Maxillofacial_Surgery"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="54467184" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54467184/Advanced_Biomaterials_and_Techniques_for_Oral_Tissue_Engineering_and_Regeneration_A_Review">Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration—A Review</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="151350174" href="https://umft.academia.edu/DragosCraciun">Dragos Craciun</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Materials</p><p class="ds-related-work--abstract ds2-5-body-sm">The reconstruction or repair of oral and maxillofacial functionalities and aesthetics is a priority for patients affected by tooth loss, congenital defects, trauma deformities, or various dental diseases. Therefore, in dental medicine, tissue reconstruction represents a major interest in oral and maxillofacial surgery, periodontics, orthodontics, endodontics, and even daily clinical practice. The current clinical approaches involve a vast array of techniques ranging from the traditional use of tissue grafts to the most innovative regenerative procedures, such as tissue engineering. In recent decades, a wide range of both artificial and natural biomaterials and scaffolds, genes, stem cells isolated from the mouth area (dental follicle, deciduous teeth, periodontal ligament, dental pulp, salivary glands, and adipose tissue), and various growth factors have been tested in tissue engineering approaches in dentistry, with many being proven successful. However, to fully eliminate the prob...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration—A Review","attachmentId":70815674,"attachmentType":"pdf","work_url":"https://www.academia.edu/54467184/Advanced_Biomaterials_and_Techniques_for_Oral_Tissue_Engineering_and_Regeneration_A_Review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/54467184/Advanced_Biomaterials_and_Techniques_for_Oral_Tissue_Engineering_and_Regeneration_A_Review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":49790849,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":49790849,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_49790849" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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