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</ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="//donate.wikimedia.org/wiki/Special:FundraiserRedirector?utm_source=donate&utm_medium=sidebar&utm_campaign=C13_fr.wikipedia.org&uselang=fr" class=""><span>Faire un don</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Sp%C3%A9cial:Cr%C3%A9er_un_compte&returnto=Interleukine" title="Nous vous encourageons à créer un compte utilisateur et vous connecter ; ce n’est cependant pas obligatoire." class=""><span>Créer un compte</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" 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</header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Sommaire" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Sommaire</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">masquer</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Début</div> </a> </li> <li id="toc-Interleukine_2" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interleukine_2"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Interleukine 2</span> </div> </a> <ul id="toc-Interleukine_2-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Famille_de_l'interleukine-1" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Famille_de_l'interleukine-1"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Famille de l'interleukine-1</span> </div> </a> <button aria-controls="toc-Famille_de_l'interleukine-1-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Afficher / masquer la sous-section Famille de l'interleukine-1</span> </button> <ul id="toc-Famille_de_l'interleukine-1-sublist" class="vector-toc-list"> <li id="toc-Interleukine_1" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Interleukine_1"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Interleukine 1</span> </div> </a> <ul id="toc-Interleukine_1-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Famille_de_l'interleukine-6" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Famille_de_l'interleukine-6"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Famille de l'interleukine-6</span> </div> </a> <ul id="toc-Famille_de_l'interleukine-6-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Famille_de_l'interleukine-10" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Famille_de_l'interleukine-10"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Famille de l'interleukine-10</span> </div> </a> <ul id="toc-Famille_de_l'interleukine-10-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Famille_de_l'interleukine-12" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Famille_de_l'interleukine-12"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Famille de l'interleukine-12</span> </div> </a> <ul id="toc-Famille_de_l'interleukine-12-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Liste_d'interleukines_connues_et_de_leurs_fonctions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Liste_d'interleukines_connues_et_de_leurs_fonctions"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Liste d'interleukines connues et de leurs fonctions</span> </div> </a> <ul id="toc-Liste_d'interleukines_connues_et_de_leurs_fonctions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Notes_et_références" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Notes_et_références"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Notes et références</span> </div> </a> <ul id="toc-Notes_et_références-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sommaire" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Basculer la table des matières" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Basculer la table des matières</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Interleukine</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 31 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-31" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">31 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A5%D9%86%D8%AA%D8%B1%D9%84%D9%88%D9%83%D9%8A%D9%86" title="إنترلوكين – arabe" lang="ar" hreflang="ar" data-title="إنترلوكين" data-language-autonym="العربية" data-language-local-name="arabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-az mw-list-item"><a href="https://az.wikipedia.org/wiki/%C4%B0nterleykinl%C9%99r" title="İnterleykinlər – azerbaïdjanais" lang="az" hreflang="az" data-title="İnterleykinlər" data-language-autonym="Azərbaycanca" data-language-local-name="azerbaïdjanais" class="interlanguage-link-target"><span>Azərbaycanca</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D0%B2%D0%BA%D0%B8%D0%BD" title="Интерлевкин – bulgare" lang="bg" hreflang="bg" data-title="Интерлевкин" data-language-autonym="Български" data-language-local-name="bulgare" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Interleukin" title="Interleukin – bosniaque" lang="bs" hreflang="bs" data-title="Interleukin" data-language-autonym="Bosanski" data-language-local-name="bosniaque" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Interleucina" title="Interleucina – catalan" lang="ca" hreflang="ca" data-title="Interleucina" data-language-autonym="Català" data-language-local-name="catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Interleukiny" title="Interleukiny – tchèque" lang="cs" hreflang="cs" data-title="Interleukiny" data-language-autonym="Čeština" data-language-local-name="tchèque" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Interleukine" title="Interleukine – allemand" lang="de" hreflang="de" data-title="Interleukine" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Interleukin" title="Interleukin – anglais" lang="en" hreflang="en" data-title="Interleukin" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Interleucina" title="Interleucina – espagnol" lang="es" hreflang="es" data-title="Interleucina" data-language-autonym="Español" data-language-local-name="espagnol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Interleukina" title="Interleukina – basque" lang="eu" hreflang="eu" data-title="Interleukina" data-language-autonym="Euskara" data-language-local-name="basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%84%D9%88%DA%A9%DB%8C%D9%86" title="اینترلوکین – persan" lang="fa" hreflang="fa" data-title="اینترلوکین" data-language-autonym="فارسی" data-language-local-name="persan" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Interleukiini" title="Interleukiini – finnois" lang="fi" hreflang="fi" data-title="Interleukiini" data-language-autonym="Suomi" data-language-local-name="finnois" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Interleucina" title="Interleucina – galicien" lang="gl" hreflang="gl" data-title="Interleucina" data-language-autonym="Galego" data-language-local-name="galicien" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%99%D7%A0%D7%98%D7%A8%D7%9C%D7%95%D7%A7%D7%99%D7%9F" title="אינטרלוקין – hébreu" lang="he" hreflang="he" data-title="אינטרלוקין" data-language-autonym="עברית" data-language-local-name="hébreu" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Interleukin" title="Interleukin – hongrois" lang="hu" hreflang="hu" data-title="Interleukin" data-language-autonym="Magyar" data-language-local-name="hongrois" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Interleukin" title="Interleukin – indonésien" lang="id" hreflang="id" data-title="Interleukin" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonésien" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Interleuchine" title="Interleuchine – italien" lang="it" hreflang="it" data-title="Interleuchine" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A4%E3%83%B3%E3%82%BF%E3%83%BC%E3%83%AD%E3%82%A4%E3%82%AD%E3%83%B3" title="インターロイキン – japonais" lang="ja" hreflang="ja" data-title="インターロイキン" data-language-autonym="日本語" data-language-local-name="japonais" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%9D%B8%ED%84%B0%EB%A3%A8%ED%82%A8" title="인터루킨 – coréen" lang="ko" hreflang="ko" data-title="인터루킨" data-language-autonym="한국어" data-language-local-name="coréen" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Interleukinum" title="Interleukinum – latin" lang="la" hreflang="la" data-title="Interleukinum" data-language-autonym="Latina" data-language-local-name="latin" class="interlanguage-link-target"><span>Latina</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Interleukin" title="Interleukin – malais" lang="ms" hreflang="ms" data-title="Interleukin" data-language-autonym="Bahasa Melayu" data-language-local-name="malais" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Interleukine" title="Interleukine – néerlandais" lang="nl" hreflang="nl" data-title="Interleukine" data-language-autonym="Nederlands" data-language-local-name="néerlandais" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukiny" title="Interleukiny – polonais" lang="pl" hreflang="pl" data-title="Interleukiny" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interleucina" title="Interleucina – portugais" lang="pt" hreflang="pt" data-title="Interleucina" data-language-autonym="Português" data-language-local-name="portugais" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D0%B9%D0%BA%D0%B8%D0%BD%D1%8B" title="Интерлейкины – russe" lang="ru" hreflang="ru" data-title="Интерлейкины" data-language-autonym="Русский" data-language-local-name="russe" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Interleukin" title="Interleukin – serbo-croate" lang="sh" hreflang="sh" data-title="Interleukin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Interlevkin" title="Interlevkin – slovène" lang="sl" hreflang="sl" data-title="Interlevkin" data-language-autonym="Slovenščina" data-language-local-name="slovène" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD%D0%B8" title="Интерлеукини – serbe" lang="sr" hreflang="sr" data-title="Интерлеукини" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%AD%E0%B8%B4%E0%B8%99%E0%B9%80%E0%B8%95%E0%B8%AD%E0%B8%A3%E0%B9%8C%E0%B8%A5%E0%B8%B4%E0%B8%A7%E0%B8%84%E0%B8%B4%E0%B8%99" title="อินเตอร์ลิวคิน – thaï" lang="th" hreflang="th" data-title="อินเตอร์ลิวคิน" data-language-autonym="ไทย" data-language-local-name="thaï" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/%C4%B0nterl%C3%B6kin" title="İnterlökin – turc" lang="tr" hreflang="tr" data-title="İnterlökin" data-language-autonym="Türkçe" data-language-local-name="turc" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%99%BD%E7%BB%86%E8%83%9E%E4%BB%8B%E7%B4%A0" title="白细胞介素 – chinois" lang="zh" hreflang="zh" data-title="白细胞介素" data-language-autonym="中文" data-language-local-name="chinois" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q194908#sitelinks-wikipedia" title="Modifier les liens interlangues" class="wbc-editpage">Modifier les liens</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Espaces de noms"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div 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><span class="vector-dropdown-label-text">Outils</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Outils</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">masquer</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Plus d’options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Interleukine"><span>Lire</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukine&veaction=edit" title="Modifier cette page [v]" accesskey="v"><span>Modifier</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukine&action=edit" title="Modifier le wikicode de cette page [e]" accesskey="e"><span>Modifier le code</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukine&action=history"><span>Voir l’historique</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Général </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Pages_li%C3%A9es/Interleukine" title="Liste des pages liées qui pointent sur celle-ci [j]" accesskey="j"><span>Pages liées</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Suivi_des_liens/Interleukine" rel="nofollow" title="Liste des modifications récentes des pages appelées par celle-ci [k]" accesskey="k"><span>Suivi des pages liées</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Aide:Importer_un_fichier" title="Téléverser des fichiers [u]" accesskey="u"><span>Téléverser un fichier</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Pages_sp%C3%A9ciales" title="Liste de toutes les pages spéciales [q]" accesskey="q"><span>Pages spéciales</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Interleukine&oldid=208983766" title="Adresse permanente de cette version de cette page"><span>Lien permanent</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Interleukine&action=info" title="Davantage d’informations sur cette page"><span>Informations sur la page</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:Citer&page=Interleukine&id=208983766&wpFormIdentifier=titleform" title="Informations sur la manière de citer cette page"><span>Citer cette page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:UrlShortener&url=https%3A%2F%2Ffr.wikipedia.org%2Fwiki%2FInterleukine"><span>Obtenir l'URL raccourcie</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:QrCode&url=https%3A%2F%2Ffr.wikipedia.org%2Fwiki%2FInterleukine"><span>Télécharger le code QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Imprimer / exporter </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:Livre&bookcmd=book_creator&referer=Interleukine"><span>Créer un livre</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Sp%C3%A9cial:DownloadAsPdf&page=Interleukine&action=show-download-screen"><span>Télécharger comme PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Interleukine&printable=yes" title="Version imprimable de cette page [p]" accesskey="p"><span>Version imprimable</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> Dans d’autres projets </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Interleukins" hreflang="en"><span>Wikimedia Commons</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q194908" title="Lien vers l’élément dans le dépôt de données connecté [g]" accesskey="g"><span>Élément Wikidata</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Outils de la page"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Apparence"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Apparence</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">masquer</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Un article de Wikipédia, l'encyclopédie libre.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><div class="bandeau-container metadata bandeau-article bandeau-niveau-ebauche"><div class="bandeau-cell bandeau-icone" style="display:table-cell;padding-right:0.5em"><span style="white-space:nowrap;word-spacing:5px"><span class="noviewer" typeof="mw:File"><a href="/wiki/Fichier:ADN_static_h.png" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/ADN_static_h.png/45px-ADN_static_h.png" decoding="async" width="45" height="23" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/ADN_static_h.png/68px-ADN_static_h.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d6/ADN_static_h.png/90px-ADN_static_h.png 2x" data-file-width="285" data-file-height="148" /></a></span> <span class="noviewer" typeof="mw:File"><a href="/wiki/Fichier:Star_of_life2.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/35px-Star_of_life2.svg.png" decoding="async" width="35" height="35" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/53px-Star_of_life2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/70px-Star_of_life2.svg.png 2x" data-file-width="192" data-file-height="192" /></a></span></span></div><div class="bandeau-cell" style="display:table-cell;padding-right:0.5em"> <p><strong class="bandeau-titre">Cet article est une <a href="/wiki/Aide:%C3%89bauche" title="Aide:Ébauche">ébauche</a> concernant la <a href="/wiki/Biologie" title="Biologie">biologie</a> et la <a href="/wiki/M%C3%A9decine" title="Médecine">médecine</a>.</strong> </p><p>Vous pouvez partager vos connaissances en l’améliorant (<b><a href="/wiki/Aide:Comment_modifier_une_page" title="Aide:Comment modifier une page">comment ?</a></b>) selon les recommandations des <a href="/wiki/Projet:Accueil" title="Projet:Accueil">projets correspondants</a>. </p><p>Consultez la liste des <b>tâches à accomplir</b> en <a href="/wiki/Discussion:Interleukine" title="Discussion:Interleukine">page de discussion</a>. </p> </div></div> <div class="bandeau-container metadata bandeau-article bandeau-niveau-modere"><figure class="mw-halign-right noviewer" typeof="mw:File"><a href="/wiki/Mod%C3%A8le:%C3%80_sourcer" title="Si ce bandeau n'est plus pertinent, retirez-le. Cliquez ici pour en savoir plus."><img alt="Si ce bandeau n'est plus pertinent, retirez-le. Cliquez ici pour en savoir plus." src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a><figcaption>Si ce bandeau n'est plus pertinent, retirez-le. Cliquez ici pour en savoir plus.</figcaption></figure><div class="bandeau-cell bandeau-icone" style="display:table-cell;padding-right:0.5em"><span class="noviewer" typeof="mw:File"><a href="/wiki/Fichier:2017-fr.wp-orange-source.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/2017-fr.wp-orange-source.svg/45px-2017-fr.wp-orange-source.svg.png" decoding="async" width="45" height="45" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/2017-fr.wp-orange-source.svg/68px-2017-fr.wp-orange-source.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a1/2017-fr.wp-orange-source.svg/90px-2017-fr.wp-orange-source.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></div><div class="bandeau-cell" style="display:table-cell;padding-right:0.5em"> <p><strong class="bandeau-titre">Cet article <a href="/wiki/Wikip%C3%A9dia:Citez_vos_sources" title="Wikipédia:Citez vos sources">ne cite pas suffisamment ses sources</a></strong> <small>(<time class="nowrap" datetime="2009-03" data-sort-value="2009-03">mars 2009</time>).</small> </p><p>Si vous disposez d'ouvrages ou d'articles de référence ou si vous connaissez des sites web de qualité traitant du thème abordé ici, merci de compléter l'article en donnant les <b>références utiles à sa <a href="/wiki/Wikip%C3%A9dia:V%C3%A9rifiabilit%C3%A9" title="Wikipédia:Vérifiabilité">vérifiabilité</a></b> et en les liant à la section « <a href="/wiki/Aide:Ins%C3%A9rer_une_r%C3%A9f%C3%A9rence" title="Aide:Insérer une référence">Notes et références</a> ». </p><p><b>En pratique :</b> <a href="/wiki/Wikip%C3%A9dia:Citez_vos_sources#Qualité_des_sources" title="Wikipédia:Citez vos sources">Quelles sources sont attendues ?</a> <a href="/wiki/Aide:Ins%C3%A9rer_une_r%C3%A9f%C3%A9rence_(%C3%89diteur_visuel)" title="Aide:Insérer une référence (Éditeur visuel)">Comment ajouter mes sources ?</a> </p> </div></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Fichier:3LTQ.pdb.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/3LTQ.pdb.png/220px-3LTQ.pdb.png" decoding="async" width="220" height="116" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/45/3LTQ.pdb.png/330px-3LTQ.pdb.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/45/3LTQ.pdb.png/440px-3LTQ.pdb.png 2x" data-file-width="1436" data-file-height="759" /></a><figcaption>Structure de l'interleukine 1B.</figcaption></figure> <p>Les <dfn>interleukines</dfn> (IL) sont un groupe de <a href="/wiki/Cytokine" title="Cytokine">cytokines</a>, ainsi nommées car les premières observations semblaient montrer qu'elles étaient exprimées par les globules blancs (<a href="/wiki/Leucocyte" title="Leucocyte">leucocytes</a>, d'où <i>-leukin</i>) en guise de moyen de communication (d'où <i>inter-</i>). </p><p>Le terme a été créé en 1979, une époque où n'étaient connues que deux interleukines (IL1 et IL2). Il a été découvert par la suite que les interleukines étaient produites par une large variété de tissus et cellules, et que, bien que regroupées sous cette terminologie par commodité, elles ne présentent aucune parenté biochimique ni de fonction entre elles. Elles ont été classées par numéro au gré des découvertes. Au début 2006, 31 cytokines sont connues et dénommées sous l'intitulé IL. </p><p>L'<a href="/wiki/Interleukine_8" title="Interleukine 8">interleukine-8</a> est en fait une <a href="/wiki/Chimiokine" title="Chimiokine">chimiokine</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Interleukine_2">Interleukine 2</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=1" title="Modifier la section : Interleukine 2" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=1" title="Modifier le code source de la section : Interleukine 2"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>L'<a href="/wiki/Interleukine_2" title="Interleukine 2">interleukine 2</a> est principalement produite par les lymphocytes T sécréteurs, résultants de la différenciation des lymphocytes T CD4 et dans une moindre mesure par les lymphocytes T CD8, les cellules dendritiques, les lymphocytes NK (natural killer) et NK-T (natural killer T). Contrairement à ce qui a longtemps été imaginé du fait de constats <i>in vitro</i>, sa principale fonction n'est pas tant la multiplication <i>in vivo</i> des lymphocytes T et B que la régulation des lymphocytes T régulateurs, dont elle assure l’homéostasie et promeut les fonctions, permettant ainsi à ces cellules T régulatrices qui limitent l’action des cellules effectrices, de prévenir les dérives réactionnelles auto-immunes<sup id="cite_ref-:3_1-0" class="reference"><a href="#cite_note-:3-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup>.</li></ul> <p><br /> </p> <div class="mw-heading mw-heading2"><h2 id="Famille_de_l'interleukine-1"><span id="Famille_de_l.27interleukine-1"></span>Famille de l'interleukine-1</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=2" title="Modifier la section : Famille de l'interleukine-1" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=2" title="Modifier le code source de la section : Famille de l'interleukine-1"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Interleukine_1">Interleukine 1</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=3" title="Modifier la section : Interleukine 1" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=3" title="Modifier le code source de la section : Interleukine 1"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>L'<a href="/wiki/Interleukine_1" title="Interleukine 1">interleukine 1</a> est sécrétée par les <a href="/wiki/Macrophage" title="Macrophage">macrophages</a> pour stimuler la prolifération puis la différenciation des <a href="/wiki/Lymphocytes_T4" class="mw-redirect" title="Lymphocytes T4">lymphocytes T CD4</a> spécifiques à un <a href="/wiki/Antig%C3%A8ne" title="Antigène">antigène</a> présenté sur les membranes des <a href="/wiki/Macrophage" title="Macrophage">macrophages</a>, et ayant préalablement été <a href="/wiki/Phagocytose" title="Phagocytose">phagocytés</a> par ces derniers.<br />Elle fut identifiée en 1972 par Gery et Waksman, qui décrivaient pour la première fois la présence d'un facteur capable de potentialiser la réponse des <a href="/wiki/Cellule_T_cytotoxique" class="mw-redirect" title="Cellule T cytotoxique">lymphocytes T CD8</a>. <br />Les gènes de l'interleukine 1 α et β se trouvent sur le bras long du <a href="/wiki/Chromosome" title="Chromosome">chromosome 2</a> constitués de 7 <a href="/wiki/Exon" title="Exon">exons</a> dont un non codant. </p><p>L'IL1 peut être sécrétée par de nombreuses cellules comme les macrophages, les lymphocytes B et T, les cellules dendritiques, les plaquettes, <abbr class="abbr" title="et cetera">etc.</abbr> Elle est présente dans les fluides biologiques (plasma, liquide amniotique…)<br />Ses actions sont variées et redondantes avec celles du <a href="/wiki/Facteur_de_n%C3%A9crose_tumorale" title="Facteur de nécrose tumorale">TNF</a> : augmentation de la température corporelle (fièvre), dérèglement du sommeil, rejet de <a href="/wiki/Greffe_(m%C3%A9decine)" title="Greffe (médecine)">greffe</a>, prolifération de <a href="/wiki/Fibroblaste" title="Fibroblaste">fibroblastes</a>. </p> <table class="wikitable"> <caption>La famille de l'interleukine-1 <sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup> </caption> <tbody><tr> <th>Nom </th> <th>Origine </th> <th>Récepteur </th> <th>Cellules R + </th> <th>Réponse Th </th> <th>Signalisation </th> <th>Transcription </th> <th>Pro-I </th> <th>Anti-I </th></tr> <tr> <td><a href="/wiki/Interleukine_1" title="Interleukine 1">IL-1 beta</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_1" title="Interleukine 1">IL-1 gamma</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine-18" class="mw-redirect" title="Interleukine-18">IL-18</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_33" title="Interleukine 33">IL-33</a> </td> <td><a href="/wiki/Endoth%C3%A9lium" title="Endothélium">Endothélium</a> <sup id="cite_ref-:0_3-0" class="reference"><a href="#cite_note-:0-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup>, <a href="/wiki/K%C3%A9ratinocyte" title="Kératinocyte">Kératinocyte</a> <sup id="cite_ref-:0_3-1" class="reference"><a href="#cite_note-:0-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup> <p><a href="/wiki/Fibroblaste" title="Fibroblaste">Fibroblaste</a> <sup id="cite_ref-:0_3-2" class="reference"><a href="#cite_note-:0-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup> <a href="/wiki/Myocyte" title="Myocyte">Myocyte lisse</a> <sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite_crochet">[</span>4<span class="cite_crochet">]</span></a></sup>, </p><p>Épithélium<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite_crochet">[</span>5<span class="cite_crochet">]</span></a></sup> </p> </td> <td>Complexe ST2/IL-1RAcP <sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite_crochet">[</span>6<span class="cite_crochet">]</span></a></sup> </td> <td><a href="/wiki/Mastocyte" title="Mastocyte">Mastocyte</a> <sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite_crochet">[</span>7<span class="cite_crochet">]</span></a></sup> <p><a href="/wiki/Granulocyte_basophile" title="Granulocyte basophile">Neutrophile</a> <sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite_crochet">[</span>8<span class="cite_crochet">]</span></a></sup> <br /> </p> </td> <td>Th2<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite_crochet">[</span>9<span class="cite_crochet">]</span></a></sup> </td> <td>JAK2<sup id="cite_ref-:1_10-0" class="reference"><a href="#cite_note-:1-10"><span class="cite_crochet">[</span>10<span class="cite_crochet">]</span></a></sup> </td> <td>NFκB<sup id="cite_ref-:1_10-1" class="reference"><a href="#cite_note-:1-10"><span class="cite_crochet">[</span>10<span class="cite_crochet">]</span></a></sup> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine-36" title="Interleukine-36">IL-36</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/w/index.php?title=Interleukine-37&action=edit&redlink=1" class="new" title="Interleukine-37 (page inexistante)">Il-37</a><sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite_crochet">[</span>11<span class="cite_crochet">]</span></a></sup> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/w/index.php?title=Interleukine-38&action=edit&redlink=1" class="new" title="Interleukine-38 (page inexistante)">IL-38</a> <sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite_crochet">[</span>12<span class="cite_crochet">]</span></a></sup> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Famille_de_l'interleukine-6"><span id="Famille_de_l.27interleukine-6"></span>Famille de l'interleukine-6</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=4" title="Modifier la section : Famille de l'interleukine-6" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=4" title="Modifier le code source de la section : Famille de l'interleukine-6"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <table class="wikitable"> <caption>La famille de l'interleukine-6 <sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite_crochet">[</span>13<span class="cite_crochet">]</span></a></sup><sup class="reference cite_virgule">,</sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite_crochet">[</span>14<span class="cite_crochet">]</span></a></sup><sup class="reference cite_virgule">,</sup><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite_crochet">[</span>15<span class="cite_crochet">]</span></a></sup> </caption> <tbody><tr> <th>Nom </th> <th>Origine </th> <th>Récepteur </th> <th>Cellules R + </th> <th>Réponse Th </th> <th>Signalisation </th> <th>Transcription </th> <th>Pro-I </th> <th>Anti-I </th></tr> <tr> <td><a href="/wiki/Interleukine_6" title="Interleukine 6">IL6</a> </td> <td> </td> <td>gp130 </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/w/index.php?title=Interleukine_11&action=edit&redlink=1" class="new" title="Interleukine 11 (page inexistante)">IL11</a> </td> <td> </td> <td>gp130 </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td>IL-27 </td> <td> </td> <td>gp130 </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Famille_de_l'interleukine-10"><span id="Famille_de_l.27interleukine-10"></span>Famille de l'interleukine-10</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=5" title="Modifier la section : Famille de l'interleukine-10" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=5" title="Modifier le code source de la section : Famille de l'interleukine-10"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Ces cytokines partagent des sous-unités de récepteurs et des voies de signalisation communes.Tous les membres de la famille des cytokines IL-10 signalent via des récepteurs hétérodimères composés d'une chaîne α et d'une chaîne β. Cette famille échange des informations entre les cellules immunitaires et les cellules épithéliales. </p><p>Les membres de la sous-famille des cytokines IL-20 signalent à travers un récepteur qui se compose d'au moins une chaîne de récepteur IL-20 (IL-20R). L'IL-20Rβ peut se coupler avec l'IL-20Rα formant l'IL-20R de type I, qui agit comme un récepteur pour l'IL-19, l'IL-20 et l'IL-24. De plus, IL-20Rβ forme avec IL-22Rα l'IL-20R de type II par lequel IL-20 et IL-24 peuvent signaler <sup id="cite_ref-:2_16-0" class="reference"><a href="#cite_note-:2-16"><span class="cite_crochet">[</span>16<span class="cite_crochet">]</span></a></sup>. L'IL-26, qui n'est présente que chez l'homme et non chez la souris, émet des signaux via le récepteur de l'IL-26 qui se compose d'IL-20Rα et d'IL-10Rβ <sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite_crochet">[</span>17<span class="cite_crochet">]</span></a></sup>. De plus, IL-22Rα et IL-10Rβ forment le récepteur IL-22 pour IL-22<sup id="cite_ref-:2_16-1" class="reference"><a href="#cite_note-:2-16"><span class="cite_crochet">[</span>16<span class="cite_crochet">]</span></a></sup>. </p> <table class="wikitable"> <tbody><tr> <th>Nom </th> <th>Origine </th> <th>Récepteur </th> <th>Cellules R + </th> <th>Réponse Th </th> <th>Signalisation </th> <th>Transcription </th> <th>Pro-I </th> <th>Anti-I </th></tr> <tr> <td><a href="/wiki/Interleukine_10" title="Interleukine 10">IL-10</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_12" title="Interleukine 12">IL-12</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_22" title="Interleukine 22">IL-22</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td colspan="7"><b>Sous-famille de l'interleukine 20</b> </td> <td> </td> <td> </td></tr> <tr> <td colspan="7">Récepteur Interleukine 20 type 1 </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_19" title="Interleukine 19">IL-19</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_20" title="Interleukine 20">IL-20</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_24" title="Interleukine 24">IL-24</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td colspan="7">Récepteur Interleukine 20 type 2 </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_20" title="Interleukine 20">IL-20</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_24" title="Interleukine 24">IL-24</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Famille_de_l'interleukine-12"><span id="Famille_de_l.27interleukine-12"></span>Famille de l'interleukine-12</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=6" title="Modifier la section : Famille de l'interleukine-12" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=6" title="Modifier le code source de la section : Famille de l'interleukine-12"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <table class="wikitable"> <caption>La famille de l'interleukine-12 <sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite_crochet">[</span>18<span class="cite_crochet">]</span></a></sup> </caption> <tbody><tr> <th>Nom </th> <th>Origine </th> <th>Récepteur </th> <th>Cellules R + </th> <th>Réponse Th </th> <th>Signalisation </th> <th>Transcription </th> <th>Pro-I </th> <th>Anti-I </th></tr> <tr> <td><a href="/wiki/Interleukine_12" title="Interleukine 12">IL-12</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_23" title="Interleukine 23">IL-23</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/wiki/Interleukine_27" title="Interleukine 27">IL-27</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr> <tr> <td><a href="/w/index.php?title=Interleukine-35&action=edit&redlink=1" class="new" title="Interleukine-35 (page inexistante)">IL-35</a> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td> <td> </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Liste_d'interleukines_connues_et_de_leurs_fonctions"><span id="Liste_d.27interleukines_connues_et_de_leurs_fonctions"></span>Liste d'interleukines connues et de leurs fonctions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=7" title="Modifier la section : Liste d'interleukines connues et de leurs fonctions" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=7" title="Modifier le code source de la section : Liste d'interleukines connues et de leurs fonctions"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>IL1 : engendre une réponse lymphocytaire.</li> <li><a href="/wiki/Interleukine_2" title="Interleukine 2">IL2</a> : sécrétée par les <a href="/wiki/Lymphocyte_T4" class="mw-redirect" title="Lymphocyte T4">lymphocytes T CD4</a>, elle stimule à fortes doses la prolifération lymphocytaire mais surtout régule la réaction immunitaire. Elle peut être utilisée à forte dose en <a href="/wiki/Immunoth%C3%A9rapie" title="Immunothérapie">immunothérapie</a> pour traiter certains types de cancer (mélanome, carcinome rénal), avec cependant, un taux de réponse clinique relativement modeste (15 %) ; à faibles doses, elle est utilisée dans le traitement des maladies auto-immunes et inflammatoires<sup id="cite_ref-:3_1-1" class="reference"><a href="#cite_note-:3-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup>.</li> <li><a href="/w/index.php?title=Interleukine_3&action=edit&redlink=1" class="new" title="Interleukine 3 (page inexistante)">IL3</a> : sécrétée par les <a href="/wiki/Lymphocyte_T" title="Lymphocyte T">lymphocytes T</a>, elle stimule les cellules souches de la <a href="/wiki/Moelle_osseuse" title="Moelle osseuse">moelle osseuse</a>.</li> <li><a href="/wiki/Interleukine_4" title="Interleukine 4">IL4</a> : impliquée dans la prolifération des <a href="/wiki/Lymphocyte_B" title="Lymphocyte B">lymphocytes B</a>, le développement des <a href="/wiki/Lymphocyte_T" title="Lymphocyte T">lymphocytes T</a> et des <a href="/wiki/Mastocyte" title="Mastocyte">mastocytes</a>. Elle a un rôle important dans la réponse Th2 et les réactions allergiques.</li> <li><a href="/wiki/Interleukine_5" title="Interleukine 5">IL5</a> : rôle dans la stimulation des <a href="/wiki/Lymphocyte_B" title="Lymphocyte B">lymphocytes B</a>, la production de leucocytes <a href="/wiki/%C3%89osinophile" title="Éosinophile">éosinophiles</a> et la production (ainsi que la glycosylation) des <a href="/wiki/Immunoglobuline" class="mw-redirect" title="Immunoglobuline">IgA</a>.</li> <li>IL6 : effets pro-inflammatoires directs et prolongés sur l'activation des lymphocytes.</li> <li><a href="/wiki/Interleukine_7" title="Interleukine 7">IL7</a> : impliquée dans la survie, le développement et l'<a href="/wiki/Hom%C3%A9ostasie" title="Homéostasie">homéostasie</a> des cellules B, T et NK.</li> <li><a href="/wiki/Interleukine_9" title="Interleukine 9">IL9</a> : stimule les <a href="/wiki/Mastocyte" title="Mastocyte">mastocytes</a></li> <li>IL10 : limite l'expression des molécules de complexes majeurs d'histocompatibilité et de la présentation antigéniques.</li> <li><a href="/wiki/Interleukine_13" title="Interleukine 13">IL13</a> : stimule la croissance et la différenciation des lymphocytes B, inhibe les cellules Th1 et la production de cytokines pro-inflammatoires par les macrophages.</li> <li><a href="/wiki/Interleukine_15" title="Interleukine 15">IL15</a> : stimule la maturation des <a href="/wiki/Cellule_NK" class="mw-redirect" title="Cellule NK">cellules NK</a>.</li> <li><a href="/wiki/Interleukine_17" title="Interleukine 17">IL17</a> : induit la production de <a href="/wiki/Cytokine" title="Cytokine">cytokines</a> pro-inflammatoires.</li> <li><a href="/w/index.php?title=Interleukine_21&action=edit&redlink=1" class="new" title="Interleukine 21 (page inexistante)">IL21</a></li> <li><a href="/wiki/Interleukine_22" title="Interleukine 22">IL-22</a> : sécrétée par les lymphocytes T<sub>H</sub>17, les ILC3s, les lymphocytes T CD8<sup>+</sup>, les lymphocytes T γδ, les cellules NK, les cellules myéloïdes, les fibroblastes. Leur expression est induite par l'AHR, l'IL-1β, l'IL-6, l'IL-23, Notch.</li> <li><a href="/wiki/Interleukine_31" title="Interleukine 31">IL-31</a>: sécrétion sous la dépendance d'une tyrosine kinase type Jak, implication dans la genèse du prurit dans la dermatite atopique.</li> <li><a href="/wiki/Interleukine_34" title="Interleukine 34">IL-34</a></li></ul> <p><br /> </p> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine&veaction=edit&section=8" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine&action=edit&section=8" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="references-small decimal" style=""><div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-:3-1"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-:3_1-0">a</a> et <a href="#cite_ref-:3_1-1">b</a></sup> </span><span class="reference-text"><span class="ouvrage" id="JacquesMortier2016"><span class="ouvrage" id="Yannick_JacquesErwan_Mortier2016">Yannick <span class="nom_auteur">Jacques</span> et Erwan <span class="nom_auteur">Mortier</span>, « <cite style="font-style:normal">Le renouveau de l’interleukine 2 - Modèle revisité et nouvelles applications thérapeutiques</cite> », <i>médecine/sciences</i>, <abbr class="abbr" title="volume">vol.</abbr> 32, <abbr class="abbr" title="numéros">n<sup>os</sup></abbr> 6-7,‎ <time class="nowrap" datetime="2016-06-01" data-sort-value="2016-06-01"><abbr class="abbr" title="premier">1<sup>er</sup></abbr> juin 2016</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">612–618</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/0767-0974">0767-0974</a></span> et <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1958-5381">1958-5381</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1051/medsci/20163206025">10.1051/medsci/20163206025</a></span>, <a rel="nofollow" class="external text" href="https://www.medecinesciences.org/articles/medsci/abs/2016/07/medsci20163206p612/medsci20163206p612.html">lire en ligne</a>, consulté le <time class="nowrap" datetime="2021-02-27" data-sort-value="2021-02-27">27 février 2021</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Le+renouveau+de+l%E2%80%99interleukine+2+-+Mod%C3%A8le+revisit%C3%A9+et+nouvelles+applications+th%C3%A9rapeutiques&rft.jtitle=m%C3%A9decine%2Fsciences&rft.issue=6-7&rft.aulast=Jacques&rft.aufirst=Yannick&rft.au=Mortier%2C+Erwan&rft.date=2016-06-01&rft.volume=32&rft.pages=612%E2%80%93618&rft.issn=0767-0974&rft_id=info%3Adoi%2F10.1051%2Fmedsci%2F20163206025&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink noprint"><a href="#cite_ref-2">↑</a> </span><span class="reference-text"><span class="ouvrage" id="Dinarello2011"><span class="ouvrage" id="Charles_A._Dinarello2011"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Charles A. <span class="nom_auteur">Dinarello</span>, « <cite style="font-style:normal" lang="en">Interleukin-1 in the pathogenesis and treatment of inflammatory diseases</cite> », <i><span class="lang-en" lang="en">Blood</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 117, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 14,‎ <time class="nowrap" datetime="2011-04-07" data-sort-value="2011-04-07">7 avril 2011</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">3720–3732</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/0006-4971">0006-4971</a></span>, <a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/21304099">21304099</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083294">PMC3083294</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1182/blood-2010-07-273417">10.1182/blood-2010-07-273417</a></span>, <a rel="nofollow" class="external text" href="https://ashpublications.org/blood/article/117/14/3720/20517/Interleukin-1-in-the-pathogenesis-and-treatment-of">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-07" data-sort-value="2020-05-07">7 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Interleukin-1+in+the+pathogenesis+and+treatment+of+inflammatory+diseases&rft.jtitle=Blood&rft.issue=14&rft.aulast=Dinarello&rft.aufirst=Charles+A.&rft.date=2011-04-07&rft.volume=117&rft.pages=3720%E2%80%933732&rft.issn=0006-4971&rft_id=info%3Adoi%2F10.1182%2Fblood-2010-07-273417&rft_id=info%3Apmid%2F21304099&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-:0-3"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-:0_3-0">a</a> <a href="#cite_ref-:0_3-1">b</a> et <a href="#cite_ref-:0_3-2">c</a></sup> </span><span class="reference-text"><span class="ouvrage" id="MoussionOrtegaGirard2008"><span class="ouvrage" id="Christine_MoussionNathalie_OrtegaJean-Philippe_Girard2008"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Christine <span class="nom_auteur">Moussion</span>, Nathalie <span class="nom_auteur">Ortega</span> et Jean-Philippe <span class="nom_auteur">Girard</span>, « <cite style="font-style:normal" lang="en">The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?</cite> », <i><span class="lang-en" lang="en">PLoS ONE</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 3, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 10,‎ <time class="nowrap" datetime="2008-10-06" data-sort-value="2008-10-06">6 octobre 2008</time>, e3331 <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1932-6203">1932-6203</a></span>, <a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/18836528">18836528</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556082">PMC2556082</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1371/journal.pone.0003331">10.1371/journal.pone.0003331</a></span>, <a rel="nofollow" class="external text" href="https://dx.plos.org/10.1371/journal.pone.0003331">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-06" data-sort-value="2020-05-06">6 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+IL-1-Like+Cytokine+IL-33+Is+Constitutively+Expressed+in+the+Nucleus+of+Endothelial+Cells+and+Epithelial+Cells+In+Vivo%3A+A+Novel+%E2%80%98Alarmin%E2%80%99%3F&rft.jtitle=PLoS+ONE&rft.issue=10&rft.aulast=Moussion&rft.aufirst=Christine&rft.au=Ortega%2C+Nathalie&rft.au=Girard%2C+Jean-Philippe&rft.date=2008-10-06&rft.volume=3&rft.pages=e3331&rft.issn=1932-6203&rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0003331&rft_id=info%3Apmid%2F18836528&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink noprint"><a href="#cite_ref-4">↑</a> </span><span class="reference-text">Prefontaine, D., Lajoie-Kadoch, S., Foley, S., Audusseau, S., Olivenstein, R., Halayko, A. J., Lemiere, C., Martin, J. G., and Hamid, Q. (2009). Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. <i>J. Immunol.</i> 183, 5094–5103.</span> </li> <li id="cite_note-5"><span class="mw-cite-backlink noprint"><a href="#cite_ref-5">↑</a> </span><span class="reference-text">Prefontaine, D., Nadigel, J., Chouiali, F., Audusseau, S., Semlali, A., Chakir, J., Martin, J. G., and Hamid, Q. (2010). Increased IL-33 expression by epithelial cells in bronchial asthma. <i>J. Allergy Clin. Immunol.</i> 125, 752–754.</span> </li> <li id="cite_note-6"><span class="mw-cite-backlink noprint"><a href="#cite_ref-6">↑</a> </span><span class="reference-text">Chackerian, A. A., Oldham, E. R., Murphy, E. E., Schmitz, J., Pflanz, S., and Kastelein, R. A. (2007). IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. <i>J. Immunol.</i> 179, 2551–2555.</span> </li> <li id="cite_note-7"><span class="mw-cite-backlink noprint"><a href="#cite_ref-7">↑</a> </span><span class="reference-text">Allakhverdi, Z., Smith, D. E., Comeau, M. R., and Delespesse, G. (2007b). Cutting edge: The ST2 ligand IL-33 potently activates and drives maturation of human mast cells. <i>J. Immunol.</i> 179, 2051–2054.</span> </li> <li id="cite_note-8"><span class="mw-cite-backlink noprint"><a href="#cite_ref-8">↑</a> </span><span class="reference-text">Pecaric-Petkovic, T., Didichenko, S. A., Kaempfer, S., Spiegl, N., and Dahinden, C. A. (2009). Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33. <i>Blood</i> 113, 1526–1534.</span> </li> <li id="cite_note-9"><span class="mw-cite-backlink noprint"><a href="#cite_ref-9">↑</a> </span><span class="reference-text">Xu, D., Chan, W. L., Leung, B. P., Huang, F., Wheeler, R., Piedrafita, D., Robinson, J. H., and Liew, F. Y. (1998). Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. <i>J. Exp. Med.</i> 187, 787–794.</span> </li> <li id="cite_note-:1-10"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-:1_10-0">a</a> et <a href="#cite_ref-:1_10-1">b</a></sup> </span><span class="reference-text">Funakoshi-Tago, M., Tago, K., Sato, Y., Tominaga, S., and Kasahara, T. (2011). JAK2 is an important signal transducer in IL-33-induced NF-kappaB activation. <i>Cell. Signal.</i> 23, 363–370</span> </li> <li id="cite_note-11"><span class="mw-cite-backlink noprint"><a href="#cite_ref-11">↑</a> </span><span class="reference-text"><span class="ouvrage" id="DinarelloNold-PetryNoldFujita2016"><span class="ouvrage" id="Charles_A._DinarelloClaudia_Nold-PetryMarcel_NoldMayumi_Fujita2016"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Charles A. <span class="nom_auteur">Dinarello</span>, Claudia <span class="nom_auteur">Nold-Petry</span>, Marcel <span class="nom_auteur">Nold</span> et Mayumi <span class="nom_auteur">Fujita</span>, « <cite style="font-style:normal" lang="en">Suppression of innate inflammation and immunity by interleukin-37: Highlights</cite> », <i><span class="lang-en" lang="en">European Journal of Immunology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 46, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 5,‎ <time class="nowrap" datetime="2016-05" data-sort-value="2016-05">mai 2016</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">1067–1081</span> <small style="line-height:1em;">(<a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/27060871">27060871</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5003108">PMC5003108</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1002/eji.201545828">10.1002/eji.201545828</a></span>, <a rel="nofollow" class="external text" href="http://doi.wiley.com/10.1002/eji.201545828">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-07" data-sort-value="2020-05-07">7 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Suppression+of+innate+inflammation+and+immunity+by+interleukin-37%3A+Highlights&rft.jtitle=European+Journal+of+Immunology&rft.issue=5&rft.aulast=Dinarello&rft.aufirst=Charles+A.&rft.au=Nold-Petry%2C+Claudia&rft.au=Nold%2C+Marcel&rft.au=Fujita%2C+Mayumi&rft.date=2016-05&rft.volume=46&rft.pages=1067%E2%80%931081&rft_id=info%3Adoi%2F10.1002%2Feji.201545828&rft_id=info%3Apmid%2F27060871&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink noprint"><a href="#cite_ref-12">↑</a> </span><span class="reference-text"><span class="ouvrage" id="LinHoHaley-VicenteZhang2001"><span class="ouvrage" id="Haishan_LinAlice_S._HoDana_Haley-VicenteJun_Zhang2001"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Haishan <span class="nom_auteur">Lin</span>, Alice S. <span class="nom_auteur">Ho</span>, Dana <span class="nom_auteur">Haley-Vicente</span> et Jun <span class="nom_auteur">Zhang</span>, « <cite style="font-style:normal" lang="en">Cloning and Characterization of IL-1HY2, a Novel Interleukin-1 Family Member</cite> », <i><span class="lang-en" lang="en">Journal of Biological Chemistry</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 276, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 23,‎ <time class="nowrap" datetime="2001-06-08" data-sort-value="2001-06-08">8 juin 2001</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">20597–20602</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/0021-9258">0021-9258</a></span> et <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1083-351X">1083-351X</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1074/jbc.M010095200">10.1074/jbc.M010095200</a></span>, <a rel="nofollow" class="external text" href="http://www.jbc.org/lookup/doi/10.1074/jbc.M010095200">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-07" data-sort-value="2020-05-07">7 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cloning+and+Characterization+of+IL-1HY2%2C+a+Novel+Interleukin-1+Family+Member&rft.jtitle=Journal+of+Biological+Chemistry&rft.issue=23&rft.aulast=Lin&rft.aufirst=Haishan&rft.au=Ho%2C+Alice+S.&rft.au=Haley-Vicente%2C+Dana&rft.au=Zhang%2C+Jun&rft.date=2001-06-08&rft.volume=276&rft.pages=20597%E2%80%9320602&rft.issn=0021-9258&rft_id=info%3Adoi%2F10.1074%2Fjbc.M010095200&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink noprint"><a href="#cite_ref-13">↑</a> </span><span class="reference-text"><span class="ouvrage" id="HeinrichBehrmannHaanHermanns2003"><span class="ouvrage" id="Peter_C._HeinrichIris_BehrmannSerge_HaanHeike_M._Hermanns2003"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Peter C. <span class="nom_auteur">Heinrich</span>, Iris <span class="nom_auteur">Behrmann</span>, Serge <span class="nom_auteur">Haan</span> et Heike M. <span class="nom_auteur">Hermanns</span>, « <cite style="font-style:normal" lang="en">Principles of interleukin (IL)-6-type cytokine signalling and its regulation</cite> », <i><span class="lang-en" lang="en">Biochemical Journal</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 374, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 1,‎ <time class="nowrap" datetime="2003-08-15" data-sort-value="2003-08-15">15 août 2003</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">1–20</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/0264-6021">0264-6021</a></span> et <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1470-8728">1470-8728</a></span>, <a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/12773095">12773095</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223585">PMC1223585</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1042/bj20030407">10.1042/bj20030407</a></span>, <a rel="nofollow" class="external text" href="https://portlandpress.com/biochemj/article/374/1/1/43650/Principles-of-interleukin-IL6type-cytokine">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-09" data-sort-value="2020-05-09">9 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Principles+of+interleukin+%28IL%29-6-type+cytokine+signalling+and+its+regulation&rft.jtitle=Biochemical+Journal&rft.issue=1&rft.aulast=Heinrich&rft.aufirst=Peter+C.&rft.au=Behrmann%2C+Iris&rft.au=Haan%2C+Serge&rft.au=Hermanns%2C+Heike+M.&rft.date=2003-08-15&rft.volume=374&rft.pages=1%E2%80%9320&rft.issn=0264-6021&rft_id=info%3Adoi%2F10.1042%2Fbj20030407&rft_id=info%3Apmid%2F12773095&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink noprint"><a href="#cite_ref-14">↑</a> </span><span class="reference-text"><span class="ouvrage" id="SchellerGrötzingerRose-John2006"><span class="ouvrage" id="Jürgen_SchellerJoachim_GrötzingerStefan_Rose-John2006"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Jürgen <span class="nom_auteur">Scheller</span>, Joachim <span class="nom_auteur">Grötzinger</span> et Stefan <span class="nom_auteur">Rose-John</span>, « <cite style="font-style:normal" lang="en">Updating interleukin-6 classic- and trans-signaling</cite> », <i><span class="lang-en" lang="en">Signal Transduction</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 6, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 4,‎ <time class="nowrap" datetime="2006-08" data-sort-value="2006-08">août 2006</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">240–259</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1615-4053">1615-4053</a></span> et <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1615-4061">1615-4061</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1002/sita.200600086">10.1002/sita.200600086</a></span>, <a rel="nofollow" class="external text" href="http://doi.wiley.com/10.1002/sita.200600086">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-09" data-sort-value="2020-05-09">9 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Updating+interleukin-6+classic-+and+trans-signaling&rft.jtitle=Signal+Transduction&rft.issue=4&rft.aulast=Scheller&rft.aufirst=J%C3%BCrgen&rft.au=Gr%C3%B6tzinger%2C+Joachim&rft.au=Rose-John%2C+Stefan&rft.date=2006-08&rft.volume=6&rft.pages=240%E2%80%93259&rft.issn=1615-4053&rft_id=info%3Adoi%2F10.1002%2Fsita.200600086&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink noprint"><a href="#cite_ref-15">↑</a> </span><span class="reference-text"><span class="ouvrage" id="Costa-Pereira2014"><span class="ouvrage" id="Ana_P._Costa-Pereira2014"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Ana P. <span class="nom_auteur">Costa-Pereira</span>, « <cite style="font-style:normal" lang="en">Regulation of IL-6-type cytokine responses by MAPKs</cite> », <i><span class="lang-en" lang="en">Biochemical Society Transactions</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 42, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 1,‎ <time class="nowrap" datetime="2014-02-01" data-sort-value="2014-02-01"><abbr class="abbr" title="premier">1<sup>er</sup></abbr> février 2014</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">59–62</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/0300-5127">0300-5127</a></span> et <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1470-8752">1470-8752</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1042/BST20130267">10.1042/BST20130267</a></span>, <a rel="nofollow" class="external text" href="https://portlandpress.com/biochemsoctrans/article/42/1/59/65749/Regulation-of-IL6type-cytokine-responses-by-MAPKs">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-09" data-sort-value="2020-05-09">9 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+of+IL-6-type+cytokine+responses+by+MAPKs&rft.jtitle=Biochemical+Society+Transactions&rft.issue=1&rft.aulast=Costa-Pereira&rft.aufirst=Ana+P.&rft.date=2014-02-01&rft.volume=42&rft.pages=59%E2%80%9362&rft.issn=0300-5127&rft_id=info%3Adoi%2F10.1042%2FBST20130267&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-:2-16"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-:2_16-0">a</a> et <a href="#cite_ref-:2_16-1">b</a></sup> </span><span class="reference-text"><span class="ouvrage" id="OuyangRutzCrellinValdez2011"><span class="ouvrage" id="Wenjun_OuyangSascha_RutzNatasha_K._CrellinPatricia_A._Valdez2011"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Wenjun <span class="nom_auteur">Ouyang</span>, Sascha <span class="nom_auteur">Rutz</span>, Natasha K. <span class="nom_auteur">Crellin</span> et Patricia A. <span class="nom_auteur">Valdez</span>, « <cite style="font-style:normal" lang="en">Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease</cite> », <i><span class="lang-en" lang="en">Annual Review of Immunology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 29, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 1,‎ <time class="nowrap" datetime="2011-04-23" data-sort-value="2011-04-23">23 avril 2011</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">71–109</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/0732-0582">0732-0582</a></span> et <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1545-3278">1545-3278</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1146/annurev-immunol-031210-101312">10.1146/annurev-immunol-031210-101312</a></span>, <a rel="nofollow" class="external text" href="http://www.annualreviews.org/doi/10.1146/annurev-immunol-031210-101312">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-07" data-sort-value="2020-05-07">7 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Regulation+and+Functions+of+the+IL-10+Family+of+Cytokines+in+Inflammation+and+Disease&rft.jtitle=Annual+Review+of+Immunology&rft.issue=1&rft.aulast=Ouyang&rft.aufirst=Wenjun&rft.au=Rutz%2C+Sascha&rft.au=Crellin%2C+Natasha+K.&rft.au=Valdez%2C+Patricia+A.&rft.date=2011-04-23&rft.volume=29&rft.pages=71%E2%80%93109&rft.issn=0732-0582&rft_id=info%3Adoi%2F10.1146%2Fannurev-immunol-031210-101312&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink noprint"><a href="#cite_ref-17">↑</a> </span><span class="reference-text"><span class="ouvrage" id="SheikhBaurinLewis-AntesShah2004"><span class="ouvrage" id="Faruk_SheikhVitaliy_V._BaurinAnita_Lewis-AntesNital_K._Shah2004"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Faruk <span class="nom_auteur">Sheikh</span>, Vitaliy V. <span class="nom_auteur">Baurin</span>, Anita <span class="nom_auteur">Lewis-Antes</span> et Nital K. <span class="nom_auteur">Shah</span>, « <cite style="font-style:normal" lang="en">Cutting Edge: IL-26 Signals through a Novel Receptor Complex Composed of IL-20 Receptor 1 and IL-10 Receptor 2</cite> », <i><span class="lang-en" lang="en">The Journal of Immunology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 172, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 4,‎ <time class="nowrap" datetime="2004-02-15" data-sort-value="2004-02-15">15 février 2004</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">2006–2010</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/0022-1767">0022-1767</a></span> et <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1550-6606">1550-6606</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.4049/jimmunol.172.4.2006">10.4049/jimmunol.172.4.2006</a></span>, <a rel="nofollow" class="external text" href="http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.172.4.2006">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-07" data-sort-value="2020-05-07">7 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cutting+Edge%3A+IL-26+Signals+through+a+Novel+Receptor+Complex+Composed+of+IL-20+Receptor+1+and+IL-10+Receptor+2&rft.jtitle=The+Journal+of+Immunology&rft.issue=4&rft.aulast=Sheikh&rft.aufirst=Faruk&rft.au=Baurin%2C+Vitaliy+V.&rft.au=Lewis-Antes%2C+Anita&rft.au=Shah%2C+Nital+K.&rft.date=2004-02-15&rft.volume=172&rft.pages=2006%E2%80%932010&rft.issn=0022-1767&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.172.4.2006&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink noprint"><a href="#cite_ref-18">↑</a> </span><span class="reference-text"><span class="ouvrage" id="VignaliKuchroo2012"><span class="ouvrage" id="Dario_A._A._VignaliVijay_K._Kuchroo2012"><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Dario A. A. <span class="nom_auteur">Vignali</span> et Vijay K. <span class="nom_auteur">Kuchroo</span>, « <cite style="font-style:normal" lang="en">IL-12 family cytokines: immunological playmakers</cite> », <i><span class="lang-en" lang="en">Nature Immunology</span></i>, <abbr class="abbr" title="volume">vol.</abbr> 13, <abbr class="abbr" title="numéro">n<sup>o</sup></abbr> 8,‎ <time class="nowrap" datetime="2012-08" data-sort-value="2012-08">août 2012</time>, <abbr class="abbr" title="pages">p.</abbr> <span class="nowrap">722–728</span> <small style="line-height:1em;">(<a href="/wiki/International_Standard_Serial_Number" title="International Standard Serial Number">ISSN</a> <span class="plainlinks noarchive"><a rel="nofollow" class="external text" href="https://portal.issn.org/resource/issn/1529-2916">1529-2916</a></span>, <a href="/wiki/PubMed" title="PubMed">PMID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pubmed/22814351">22814351</a></span>, <a href="/wiki/PubMed_Central" title="PubMed Central">PMCID</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158817">PMC4158817</a></span>, <a href="/wiki/Digital_Object_Identifier" title="Digital Object Identifier">DOI</a> <span class="plainlinks noarchive nowrap"><a rel="nofollow" class="external text" href="https://dx.doi.org/10.1038/ni.2366">10.1038/ni.2366</a></span>, <a rel="nofollow" class="external text" href="https://www.nature.com/articles/ni.2366">lire en ligne</a>, consulté le <time class="nowrap" datetime="2020-05-07" data-sort-value="2020-05-07">7 mai 2020</time>)</small><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IL-12+family+cytokines%3A+immunological+playmakers&rft.jtitle=Nature+Immunology&rft.issue=8&rft.aulast=Vignali&rft.aufirst=Dario+A.+A.&rft.au=Kuchroo%2C+Vijay+K.&rft.date=2012-08&rft.volume=13&rft.pages=722%E2%80%93728&rft.issn=1529-2916&rft_id=info%3Adoi%2F10.1038%2Fni.2366&rft_id=info%3Apmid%2F22814351&rfr_id=info%3Asid%2Ffr.wikipedia.org%3AInterleukine"></span></span></span></span> </li> </ol></div> </div> <div class="navbox-container" style="clear:both;"> <table class="navbox collapsible noprint autocollapse" style=""> <tbody><tr><th class="navbox-title" colspan="2" style=""><div style="float:left; width:6em; text-align:left"><div class="noprint plainlinks nowrap tnavbar" style="padding:0; font-size:xx-small; color:var(--color-emphasized, #000000);"><a href="/wiki/Mod%C3%A8le:Palette_Cytokines" title="Modèle:Palette Cytokines"><abbr class="abbr" title="Voir ce modèle.">v</abbr></a> · <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Mod%C3%A8le:Palette_Cytokines&action=edit"><abbr class="abbr" title="Modifier ce modèle. Merci de prévisualiser avant de sauvegarder.">m</abbr></a></div></div><div style="font-size:110%"><a href="/wiki/Cytokine" title="Cytokine">Cytokines</a></div></th> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Chimiokine" title="Chimiokine">Chimiokines</a></th> <td class="navbox-list" style="text-align:center;"><table class="navbox-subgroup" style=""> <tbody><tr> <th class="navbox-group" style="">CCL</th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=CCL1&action=edit&redlink=1" class="new" title="CCL1 (page inexistante)">CCL1</a> <a href="https://en.wikipedia.org/wiki/CCL1" class="extiw" title="en:CCL1"><span class="indicateur-langue" title="Article en anglais : « CCL1 »">(en)</span></a></li> <li><a href="/wiki/CCL2" title="CCL2">CCL2</a></li> <li><a href="/w/index.php?title=CCL3&action=edit&redlink=1" class="new" title="CCL3 (page inexistante)">CCL3</a> <a href="https://en.wikipedia.org/wiki/CCL3" class="extiw" title="en:CCL3"><span class="indicateur-langue" title="Article en anglais : « CCL3 »">(en)</span></a></li> <li><a href="/wiki/T%C3%A9trachlorom%C3%A9thane" title="Tétrachlorométhane">CCL4</a></li> <li><a href="/w/index.php?title=CCL5&action=edit&redlink=1" class="new" title="CCL5 (page inexistante)">CCL5</a> <a href="https://en.wikipedia.org/wiki/CCL5" class="extiw" title="en:CCL5"><span class="indicateur-langue" title="Article en anglais : « CCL5 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL6&action=edit&redlink=1" class="new" title="CCL6 (page inexistante)">CCL6</a> <a href="https://en.wikipedia.org/wiki/CCL6" class="extiw" title="en:CCL6"><span class="indicateur-langue" title="Article en anglais : « CCL6 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL7&action=edit&redlink=1" class="new" title="CCL7 (page inexistante)">CCL7</a> <a href="https://en.wikipedia.org/wiki/CCL7" class="extiw" title="en:CCL7"><span class="indicateur-langue" title="Article en anglais : « CCL7 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL8&action=edit&redlink=1" class="new" title="CCL8 (page inexistante)">CCL8</a> <a href="https://en.wikipedia.org/wiki/CCL8" class="extiw" title="en:CCL8"><span class="indicateur-langue" title="Article en anglais : « CCL8 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL9&action=edit&redlink=1" class="new" title="CCL9 (page inexistante)">CCL9</a> <a href="https://en.wikipedia.org/wiki/CCL9" class="extiw" title="en:CCL9"><span class="indicateur-langue" title="Article en anglais : « CCL9 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL11&action=edit&redlink=1" class="new" title="CCL11 (page inexistante)">CCL11</a> <a href="https://en.wikipedia.org/wiki/CCL11" class="extiw" title="en:CCL11"><span class="indicateur-langue" title="Article en anglais : « CCL11 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL12&action=edit&redlink=1" class="new" title="CCL12 (page inexistante)">CCL12</a> <a href="https://en.wikipedia.org/wiki/CCL12" class="extiw" title="en:CCL12"><span class="indicateur-langue" title="Article en anglais : « CCL12 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL13&action=edit&redlink=1" class="new" title="CCL13 (page inexistante)">CCL13</a> <a href="https://en.wikipedia.org/wiki/CCL13" class="extiw" title="en:CCL13"><span class="indicateur-langue" title="Article en anglais : « CCL13 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL14&action=edit&redlink=1" class="new" title="CCL14 (page inexistante)">CCL14</a> <a href="https://en.wikipedia.org/wiki/CCL14" class="extiw" title="en:CCL14"><span class="indicateur-langue" title="Article en anglais : « CCL14 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL15&action=edit&redlink=1" class="new" title="CCL15 (page inexistante)">CCL15</a> <a href="https://en.wikipedia.org/wiki/CCL15" class="extiw" title="en:CCL15"><span class="indicateur-langue" title="Article en anglais : « CCL15 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL16&action=edit&redlink=1" class="new" title="CCL16 (page inexistante)">CCL16</a> <a href="https://en.wikipedia.org/wiki/CCL16" class="extiw" title="en:CCL16"><span class="indicateur-langue" title="Article en anglais : « CCL16 »">(en)</span></a></li> <li><a href="/wiki/CCL17" title="CCL17">CCL17</a></li> <li><a href="/w/index.php?title=CCL18&action=edit&redlink=1" class="new" title="CCL18 (page inexistante)">CCL18</a> <a href="https://en.wikipedia.org/wiki/CCL18" class="extiw" title="en:CCL18"><span class="indicateur-langue" title="Article en anglais : « CCL18 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL19&action=edit&redlink=1" class="new" title="CCL19 (page inexistante)">CCL19</a> <a href="https://en.wikipedia.org/wiki/CCL19" class="extiw" title="en:CCL19"><span class="indicateur-langue" title="Article en anglais : « CCL19 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL20&action=edit&redlink=1" class="new" title="CCL20 (page inexistante)">CCL20</a> <a href="https://en.wikipedia.org/wiki/CCL20" class="extiw" title="en:CCL20"><span class="indicateur-langue" title="Article en anglais : « CCL20 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL21&action=edit&redlink=1" class="new" title="CCL21 (page inexistante)">CCL21</a> <a href="https://en.wikipedia.org/wiki/CCL21" class="extiw" title="en:CCL21"><span class="indicateur-langue" title="Article en anglais : « CCL21 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL22&action=edit&redlink=1" class="new" title="CCL22 (page inexistante)">CCL22</a> <a href="https://en.wikipedia.org/wiki/CCL22" class="extiw" title="en:CCL22"><span class="indicateur-langue" title="Article en anglais : « CCL22 »">(en)</span></a></li> <li><a href="/wiki/CCL23" title="CCL23">CCL23</a></li> <li><a href="/w/index.php?title=CCL24&action=edit&redlink=1" class="new" title="CCL24 (page inexistante)">CCL24</a> <a href="https://en.wikipedia.org/wiki/CCL24" class="extiw" title="en:CCL24"><span class="indicateur-langue" title="Article en anglais : « CCL24 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL25&action=edit&redlink=1" class="new" title="CCL25 (page inexistante)">CCL25</a> <a href="https://en.wikipedia.org/wiki/CCL25" class="extiw" title="en:CCL25"><span class="indicateur-langue" title="Article en anglais : « CCL25 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL26&action=edit&redlink=1" class="new" title="CCL26 (page inexistante)">CCL26</a> <a href="https://en.wikipedia.org/wiki/CCL26" class="extiw" title="en:CCL26"><span class="indicateur-langue" title="Article en anglais : « CCL26 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL27&action=edit&redlink=1" class="new" title="CCL27 (page inexistante)">CCL27</a> <a href="https://en.wikipedia.org/wiki/CCL27" class="extiw" title="en:CCL27"><span class="indicateur-langue" title="Article en anglais : « CCL27 »">(en)</span></a></li> <li><a href="/w/index.php?title=CCL28&action=edit&redlink=1" class="new" title="CCL28 (page inexistante)">CCL28</a> <a href="https://en.wikipedia.org/wiki/CCL28" class="extiw" title="en:CCL28"><span class="indicateur-langue" title="Article en anglais : « CCL28 »">(en)</span></a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">CXCL</th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=CXCL1&action=edit&redlink=1" class="new" title="CXCL1 (page inexistante)">CXCL1</a> <a href="https://en.wikipedia.org/wiki/CXCL1" class="extiw" title="en:CXCL1"><span class="indicateur-langue" title="Article en anglais : « CXCL1 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL2&action=edit&redlink=1" class="new" title="CXCL2 (page inexistante)">CXCL2</a> <a href="https://en.wikipedia.org/wiki/CXCL2" class="extiw" title="en:CXCL2"><span class="indicateur-langue" title="Article en anglais : « CXCL2 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL3&action=edit&redlink=1" class="new" title="CXCL3 (page inexistante)">CXCL3</a> <a href="https://en.wikipedia.org/wiki/CXCL3" class="extiw" title="en:CXCL3"><span class="indicateur-langue" title="Article en anglais : « CXCL3 »">(en)</span></a></li> <li><a href="/wiki/CXCL4" title="CXCL4">CXCL4</a></li> <li><a href="/w/index.php?title=CXCL5&action=edit&redlink=1" class="new" title="CXCL5 (page inexistante)">CXCL5</a> <a href="https://en.wikipedia.org/wiki/CXCL5" class="extiw" title="en:CXCL5"><span class="indicateur-langue" title="Article en anglais : « CXCL5 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL6&action=edit&redlink=1" class="new" title="CXCL6 (page inexistante)">CXCL6</a> <a href="https://en.wikipedia.org/wiki/CXCL6" class="extiw" title="en:CXCL6"><span class="indicateur-langue" title="Article en anglais : « CXCL6 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL7&action=edit&redlink=1" class="new" title="CXCL7 (page inexistante)">CXCL7</a> <a href="https://en.wikipedia.org/wiki/CXCL7" class="extiw" title="en:CXCL7"><span class="indicateur-langue" title="Article en anglais : « CXCL7 »">(en)</span></a></li> <li><a href="/wiki/Interleukine_8" title="Interleukine 8">CXCL8/IL8</a></li> <li><a href="/w/index.php?title=CXCL9&action=edit&redlink=1" class="new" title="CXCL9 (page inexistante)">CXCL9</a> <a href="https://en.wikipedia.org/wiki/CXCL9" class="extiw" title="en:CXCL9"><span class="indicateur-langue" title="Article en anglais : « CXCL9 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL10&action=edit&redlink=1" class="new" title="CXCL10 (page inexistante)">CXCL10</a> <a href="https://en.wikipedia.org/wiki/CXCL10" class="extiw" title="en:CXCL10"><span class="indicateur-langue" title="Article en anglais : « CXCL10 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL11&action=edit&redlink=1" class="new" title="CXCL11 (page inexistante)">CXCL11</a> <a href="https://en.wikipedia.org/wiki/CXCL11" class="extiw" title="en:CXCL11"><span class="indicateur-langue" title="Article en anglais : « CXCL11 »">(en)</span></a></li> <li><a href="/wiki/CXCL12" title="CXCL12">CXCL12</a></li> <li><a href="/wiki/CXCL13" title="CXCL13">CXCL13</a></li> <li><a href="/wiki/CXCL14" title="CXCL14">CXCL14</a></li> <li><a href="/w/index.php?title=CXCL15&action=edit&redlink=1" class="new" title="CXCL15 (page inexistante)">CXCL15</a> <a href="https://en.wikipedia.org/wiki/CXCL15" class="extiw" title="en:CXCL15"><span class="indicateur-langue" title="Article en anglais : « CXCL15 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL16&action=edit&redlink=1" class="new" title="CXCL16 (page inexistante)">CXCL16</a> <a href="https://en.wikipedia.org/wiki/CXCL16" class="extiw" title="en:CXCL16"><span class="indicateur-langue" title="Article en anglais : « CXCL16 »">(en)</span></a></li> <li><a href="/w/index.php?title=CXCL17&action=edit&redlink=1" class="new" title="CXCL17 (page inexistante)">CXCL17</a> <a href="https://en.wikipedia.org/wiki/CXCL17" class="extiw" title="en:CXCL17"><span class="indicateur-langue" title="Article en anglais : « CXCL17 »">(en)</span></a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">CX3CL</th> <td class="navbox-list" style=";"><div class="liste-horizontale"> <ul><li><a href="/wiki/CX3CL1" title="CX3CL1">CX3CL1</a></li></ul> </div></td> </tr> <tr> <th class="navbox-group" style="">XCL</th> <td class="navbox-list navbox-even" style=";"><div class="liste-horizontale"> <ul><li><a href="/w/index.php?title=XCL1&action=edit&redlink=1" class="new" title="XCL1 (page inexistante)">XCL1</a> <a href="https://en.wikipedia.org/wiki/XCL1" class="extiw" title="en:XCL1"><span class="indicateur-langue" title="Article en anglais : « XCL1 »">(en)</span></a></li> <li><a href="/w/index.php?title=XCL2&action=edit&redlink=1" class="new" title="XCL2 (page inexistante)">XCL2</a> <a href="https://en.wikipedia.org/wiki/XCL2" class="extiw" title="en:XCL2"><span class="indicateur-langue" title="Article en anglais : « XCL2 »">(en)</span></a></li></ul> </div></td> </tr> </tbody></table></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Interf%C3%A9ron" title="Interféron">Interférons</a></th> <td class="navbox-list navbox-even" style="text-align:center;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Interf%C3%A9ron_de_type_I" title="Interféron de type I">IFN-α</a></li> <li><a href="/wiki/Interf%C3%A9ron_b%C3%AAta-1a" title="Interféron bêta-1a">IFN-β</a> (<a href="/wiki/Interf%C3%A9ron_b%C3%AAta-1a" title="Interféron bêta-1a">IFNβ1a</a>)</li> <li><a href="/w/index.php?title=Interf%C3%A9ron_om%C3%A9ga&action=edit&redlink=1" class="new" title="Interféron oméga (page inexistante)">IFN-ω</a></li> <li><a href="/wiki/Interf%C3%A9ron_gamma" title="Interféron gamma">IFNγ</a>, etc.</li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a class="mw-selflink selflink">Interleukines</a></th> <td class="navbox-list" style="text-align:center;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Interleukine_1" title="Interleukine 1">IL1</a></li> <li><a href="/wiki/Interleukine_2" title="Interleukine 2">IL2</a></li> <li><a href="/w/index.php?title=Interleukine_3&action=edit&redlink=1" class="new" title="Interleukine 3 (page inexistante)">IL3</a></li> <li><a href="/wiki/Interleukine_4" title="Interleukine 4">IL4</a></li> <li><a href="/wiki/Interleukine_5" title="Interleukine 5">IL5</a></li> <li><a href="/wiki/Interleukine_6" title="Interleukine 6">IL6</a></li> <li><a href="/wiki/Interleukine_7" title="Interleukine 7">IL7</a></li> <li><a href="/wiki/Interleukine_8" title="Interleukine 8">IL8</a></li> <li><a href="/wiki/Interleukine_9" title="Interleukine 9">IL9</a></li> <li><a href="/wiki/Interleukine_10" title="Interleukine 10">IL10</a></li> <li><a href="/w/index.php?title=Interleukine_11&action=edit&redlink=1" class="new" title="Interleukine 11 (page inexistante)">IL11</a></li> <li><a href="/wiki/Interleukine_12" title="Interleukine 12">IL12</a></li> <li><a href="/wiki/Interleukine_13" title="Interleukine 13">IL13</a></li> <li><a href="/w/index.php?title=Interleukine_14&action=edit&redlink=1" class="new" title="Interleukine 14 (page inexistante)">IL14</a></li> <li><a href="/wiki/Interleukine_15" title="Interleukine 15">IL15</a></li> <li><a href="/w/index.php?title=Interleukine_16&action=edit&redlink=1" class="new" title="Interleukine 16 (page inexistante)">IL16</a></li> <li><a href="/wiki/Interleukine_17" title="Interleukine 17">IL17</a></li> <li><a href="/wiki/Interleukine_18" title="Interleukine 18">IL18</a></li> <li><a href="/wiki/Interleukine_19" title="Interleukine 19">IL19</a></li> <li><a href="/wiki/Interleukine_20" title="Interleukine 20">IL20</a></li> <li><a href="/w/index.php?title=Interleukine_21&action=edit&redlink=1" class="new" title="Interleukine 21 (page inexistante)">IL21</a></li> <li><a href="/wiki/Interleukine_22" title="Interleukine 22">IL22</a></li> <li><a href="/wiki/Interleukine_23" title="Interleukine 23">IL23</a></li> <li><a href="/wiki/Interleukine_24" title="Interleukine 24">IL24</a>, etc.</li></ul> </div></td> </tr> <tr> <th class="navbox-group" style=""><a href="/wiki/Famille_du_facteur_de_n%C3%A9crose_tumorale" title="Famille du facteur de nécrose tumorale">Famille du TNF</a></th> <td class="navbox-list navbox-even" style="text-align:center;"><div class="liste-horizontale"> <ul><li><a href="/wiki/Facteur_de_n%C3%A9crose_tumorale" title="Facteur de nécrose tumorale">TNF α</a></li> <li><a href="/wiki/Lymphotoxine_alpha" title="Lymphotoxine alpha">LT α</a></li> <li><a href="/wiki/Lymphotoxine_b%C3%AAta" title="Lymphotoxine bêta">LT β</a></li> <li><a href="/w/index.php?title=OX40L&action=edit&redlink=1" class="new" title="OX40L (page inexistante)">OX40L</a> <a href="https://en.wikipedia.org/wiki/OX40_ligand" class="extiw" title="en:OX40 ligand"><span class="indicateur-langue" title="Article en anglais : « OX40 ligand »">(en)</span></a></li> <li><a href="/w/index.php?title=CD154&action=edit&redlink=1" class="new" title="CD154 (page inexistante)">CD154</a> <a href="https://en.wikipedia.org/wiki/CD154" class="extiw" title="en:CD154"><span class="indicateur-langue" title="Article en anglais : « CD154 »">(en)</span></a></li> <li><a href="/wiki/Ligand_de_Fas" title="Ligand de Fas">FasL</a></li> <li><a href="/w/index.php?title=CD70&action=edit&redlink=1" class="new" title="CD70 (page inexistante)">CD70</a> <a href="https://en.wikipedia.org/wiki/CD70" class="extiw" title="en:CD70"><span class="indicateur-langue" title="Article en anglais : « CD70 »">(en)</span></a></li> <li><a href="/w/index.php?title=CD153&action=edit&redlink=1" class="new" title="CD153 (page inexistante)">CD153</a> <a href="https://en.wikipedia.org/wiki/CD153" class="extiw" title="en:CD153"><span class="indicateur-langue" title="Article en anglais : « CD153 »">(en)</span></a></li> <li><a href="/wiki/TRAIL" title="TRAIL">TRAIL</a></li> <li><a href="/wiki/RANKL" title="RANKL">RANKL</a></li> <li><a href="/w/index.php?title=APRIL_(prot%C3%A9ine)&action=edit&redlink=1" class="new" title="APRIL (protéine) (page inexistante)">APRIL</a> <a href="https://en.wikipedia.org/wiki/APRIL_(protein)" class="extiw" title="en:APRIL (protein)"><span class="indicateur-langue" title="Article en anglais : « APRIL (protein) »">(en)</span></a></li> <li><a href="/wiki/BAFF_(cytokine)" title="BAFF (cytokine)">BAFF</a></li> <li><a href="/wiki/Ectodysplasine" title="Ectodysplasine">EDA</a></li></ul> </div></td> </tr> </tbody></table> </div> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer skin-invert-image" typeof="mw:File"><a 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