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class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Interleukine 31</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Aller à un article dans une autre langue. Disponible en 5 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-5" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">5 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Interleukin_31" title="Interleukin 31 – anglais" lang="en" hreflang="en" data-title="Interleukin 31" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_31" title="Interleukina 31 – polonais" lang="pl" hreflang="pl" data-title="Interleukina 31" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Interleukin_31" title="Interleukin 31 – serbo-croate" lang="sh" hreflang="sh" data-title="Interleukin 31" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croate" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_31" title="Интерлеукин 31 – serbe" lang="sr" hreflang="sr" data-title="Интерлеукин 31" data-language-autonym="Српски / srpski" data-language-local-name="serbe" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/IL31" title="IL31 – ukrainien" lang="uk" hreflang="uk" data-title="IL31" data-language-autonym="Українська" data-language-local-name="ukrainien" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q14907226#sitelinks-wikipedia" title="Modifier les liens interlangues" class="wbc-editpage">Modifier les liens</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Espaces de noms"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul 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data-event-name="pinnable-header.vector-page-tools.unpin">masquer</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Plus d’options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Interleukine_31"><span>Lire</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukine_31&veaction=edit" title="Modifier cette page [v]" accesskey="v"><span>Modifier</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukine_31&action=edit" title="Modifier le wikicode de cette page [e]" accesskey="e"><span>Modifier le code</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Interleukine_31&action=history"><span>Voir l’historique</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Général </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Pages_li%C3%A9es/Interleukine_31" title="Liste des pages liées qui pointent sur celle-ci [j]" accesskey="j"><span>Pages liées</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Sp%C3%A9cial:Suivi_des_liens/Interleukine_31" rel="nofollow" title="Liste des modifications récentes des pages appelées par celle-ci [k]" accesskey="k"><span>Suivi des pages liées</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Aide:Importer_un_fichier" title="Téléverser des fichiers [u]" accesskey="u"><span>Téléverser un fichier</span></a></li><li id="t-specialpages" 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id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Apparence</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">déplacer vers la barre latérale</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">masquer</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Un article de Wikipédia, l'encyclopédie libre.</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="fr" dir="ltr"><table class="infobox" style="float:right;border:1px solid #aaa;padding:3px;background-color:#f9f9f9;width:20em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;height:45px;font-weight:bold;background-color:#F5DEB3">IL31</th></tr><tr><td colspan="4" style="text-align:center"></td></tr><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3">Identifiants</th></tr><tr><th scope="row" style="background-color:#F5DEB3"><span class="plainlinks"><a href="/w/index.php?title=Nomenclature_des_g%C3%A8nes&action=edit&redlink=1" class="new" title="Nomenclature des gènes (page inexistante)">Aliases</a></span></th><td colspan="3" style="background:#f9f9f9"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/19372">IL31</a></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">IDs externes</th><td colspan="3" style="background-color:#f9f9f9"><span class="plainlinks"><a href="/wiki/H%C3%A9ritage_mend%C3%A9lien_chez_l%27humain" title="Héritage mendélien chez l'humain">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/609509">609509</a> <a href="/w/index.php?title=Mouse_Genome_Informatics&action=edit&redlink=1" class="new" title="Mouse Genome Informatics (page inexistante)">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1923649">1923649</a> <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=88541">88541</a> <a href="/w/index.php?title=GeneCards&action=edit&redlink=1" class="new" title="GeneCards (page inexistante)">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL31">IL31</a> </span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3">Position du gène (<a href="/wiki/Homo_sapiens" title="Homo sapiens">Homme</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span typeof="mw:File"><a href="/wiki/Fichier:Ideogram_human_chromosome_12.svg" class="mw-file-description" title="Chromosome 12 humain"><img alt="Chromosome 12 humain" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/300px-Ideogram_human_chromosome_12.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/450px-Ideogram_human_chromosome_12.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/600px-Ideogram_human_chromosome_12.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#F5DEB3"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#f9f9f9"><span class="plainlinks"><a href="/wiki/Chromosome_12_humain" title="Chromosome 12 humain">Chromosome 12 humain</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/Fichier:Human_chromosome_12_ideogram.svg" class="mw-file-description" title="Chromosome 12 humain"><img alt="Chromosome 12 humain" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/300px-Human_chromosome_12_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/450px-Human_chromosome_12_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/600px-Human_chromosome_12_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 264.23113032625px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Fichier:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Localisation génomique pour IL31"><img alt="Localisation génomique pour IL31" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 270.2px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Fichier:Red_rectangle_2x18.png" class="mw-file-description" title="Localisation génomique pour IL31"><img alt="Localisation génomique pour IL31" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#F5DEB3"><a href="/wiki/Locus" title="Locus">Locus</a></th><td rowspan="2" width="25%" style="background-color:#f9f9f9"><span class="plainlinks">12q24.31</span></td><th scope="row" style="background-color:#F5DEB3">Début</th><td style="background-color:#f9f9f9"><span class="plainlinks">122,172,029 <a href="/wiki/Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Fin</th><td style="background-color:#f9f9f9"><span class="plainlinks">122,174,221 <a href="/wiki/Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite_crochet">[</span>1<span class="cite_crochet">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3">Position du gène (<a href="/wiki/Souris_de_laboratoire" title="Souris de laboratoire">Souris</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span typeof="mw:File"><a href="/wiki/Fichier:Ideogram_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (souris)"><img alt="Chromosome 5 (souris)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/260px-Ideogram_house_mouse_chromosome_5.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/390px-Ideogram_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c0/Ideogram_house_mouse_chromosome_5.svg/520px-Ideogram_house_mouse_chromosome_5.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#F5DEB3"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#f9f9f9"><span class="plainlinks">Chromosome 5 (souris)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/Fichier:Ideogram_of_house_mouse_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (souris)"><img alt="Chromosome 5 (souris)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/300px-Ideogram_of_house_mouse_chromosome_5.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/450px-Ideogram_of_house_mouse_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/Ideogram_of_house_mouse_chromosome_5.svg/600px-Ideogram_of_house_mouse_chromosome_5.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 234.08148140128px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Fichier:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Localisation génomique pour IL31"><img alt="Localisation génomique pour IL31" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 240.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/Fichier:Red_rectangle_2x18.png" class="mw-file-description" title="Localisation génomique pour IL31"><img alt="Localisation génomique pour IL31" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#F5DEB3"><a href="/wiki/Locus" title="Locus">Locus</a></th><td rowspan="2" width="25%" style="background-color:#f9f9f9"><span class="plainlinks">5|5 F</span></td><th scope="row" style="background-color:#F5DEB3">Début</th><td style="background-color:#f9f9f9"><span class="plainlinks">123,618,220 <a href="/wiki/Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Fin</th><td style="background-color:#f9f9f9"><span class="plainlinks">123,627,552 <a href="/wiki/Paire_de_bases" title="Paire de bases">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite_crochet">[</span>2<span class="cite_crochet">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3"><a href="/wiki/Expression_g%C3%A9n%C3%A9tique" class="mw-redirect" title="Expression génétique">Expression génétique</a></th></tr><tr><th scope="row" style="background-color:#F5DEB3"><a rel="nofollow" class="external text" href="https://bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Chromosomes_humains" title="Chromosomes humains">Humain</a></b></th><th><b><a href="/wiki/Souris_de_laboratoire" title="Souris de laboratoire">Souris</a> (orthologue)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://bgee.org/gene/ENSG00000204671">Fortement exprimé dans</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">muqueuse gastrique</li><br /><li style="line-height: 137%;">appareil locomoteur humain</li><br /><li style="line-height: 137%;">muscle gastrocnémien</li><br /><li style="line-height: 137%;">îlot de Langerhans</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://bgee.org/gene/ENSMUSG00000029437">Fortement exprimé dans</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">spermatide</li><br /><li style="line-height: 137%;">spermatocyte</li><br /><li style="line-height: 137%;">tube séminifère</li><br /><li style="line-height: 137%;">zygote</li><br /><li style="line-height: 137%;">placenta</li><br /><li style="line-height: 137%;">îlot de Langerhans</li><br /><li style="line-height: 137%;">nucleus of brain</li><br /><li style="line-height: 137%;">telencephalic nucleus</li><br /><li style="line-height: 137%;">hypothalamus</li><br /><li style="line-height: 137%;">prosencéphale basal</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://bgee.org/gene/ENSG00000204671">Plus de données d'expression de référence</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9">n/a</td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><span class="plainlinks"></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3"><a href="/wiki/Gene_Ontology" title="Gene Ontology">Gene Ontology</a></th></tr><tr><td style="background-color:#F5DEB3;font-weight:bold">Fonction moléculaire</td><td style="background-color:#f9f9f9"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005125">cytokine activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005126">cytokine receptor binding</a></li></ul> </div></td></tr><tr><td style="background-color:#F5DEB3;font-weight:bold">Composant cellulaire</td><td style="background-color:#f9f9f9"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">région extracellulaire</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">milieu extracellulaire</a></li></ul> </div></td></tr><tr><td style="background-color:#F5DEB3;font-weight:bold">Processus biologique</td><td style="background-color:#f9f9f9"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002376">processus du système immunitaire</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010469">regulation of signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019221">cytokine-mediated signaling pathway</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#f9f9f9;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#f9f9f9"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#F5DEB3"><a href="/wiki/Orthologie" title="Orthologie">Orthologues</a></th></tr><tr><th scope="row" style="background-color:#F5DEB3">Espèces</th><td style="text-align:center"><b>Homme</b></td><td style="text-align:center"><b>Souris</b></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=386653&rn=1">386653</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=76399&rn=1">76399</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a href="/wiki/Ensembl" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000204671;db=core">ENSG00000204671</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000029437;db=core">ENSMUSG00000029437</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q6EBC2">Q6EBC2</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q6EAL8">Q6EAL8</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001014336">NM_001014336</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_029594">NM_029594</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3">RefSeq (protéine)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001014358">NP_001014358</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_083870">NP_083870</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Localisation (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr12:122172029-122174221">Chr 12: 122.17 – 122.17 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr5:123618220-123627552">Chr 5: 123.62 – 123.63 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#F5DEB3">Publication <a href="/wiki/PubMed" title="PubMed">PubMed</a></th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite_crochet">[</span>3<span class="cite_crochet">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite_crochet">[</span>4<span class="cite_crochet">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#f9f9f9"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;font-size:x-small;background-color:#f9f9f9"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#f9f9f9;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q14907226" class="extiw" title="d:Q14907226">Voir/Editer Humain</a></td><td colspan="2" style="background-color:#f9f9f9;text-align:center;font-size:x-small"><a href="https://www.wikidata.org/wiki/Q18267998" class="extiw" title="d:Q18267998">Voir/Editer Souris</a></td></tr></tbody></table></td></tr></tbody></table> <p>L'<b>interleukine 31</b> est une <a href="/wiki/Cytokine" title="Cytokine">cytokine</a> de type <a href="/wiki/Interleukine" title="Interleukine">interleukine</a> dont le gène est <i>IL31</i> situé sur le <a href="/wiki/Chromosome_12_humain" title="Chromosome 12 humain">chromosome 12 humain</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Rôles"><span id="R.C3.B4les"></span>Rôles</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine_31&veaction=edit&section=1" title="Modifier la section : Rôles" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine_31&action=edit&section=1" title="Modifier le code source de la section : Rôles"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Son action passe par l'intermédiaire d'un récepteur spécifique. Elle est exprimée sur certains types de <a href="/wiki/Lymphocyte_T" title="Lymphocyte T">lymphocytes T</a>, dont les <a href="/wiki/Lymphocyte_T_auxiliaire" title="Lymphocyte T auxiliaire">lymphocytes T helper</a>, et dans une moindre mesure les <a href="/wiki/Cellule_dendritique" title="Cellule dendritique">cellules dendritiques</a><sup id="cite_ref-Cevikbas_2014_5-0" class="reference"><a href="#cite_note-Cevikbas_2014-5"><span class="cite_crochet">[</span>5<span class="cite_crochet">]</span></a></sup>. Le récepteur est lui, exprimé par certains neurones exprimant également le <a href="/wiki/TRPV1" title="TRPV1">TRPV1</a> et responsables de la sensation de <a href="/wiki/Prurit" title="Prurit">prurit</a><sup id="cite_ref-Cevikbas_2014_5-1" class="reference"><a href="#cite_note-Cevikbas_2014-5"><span class="cite_crochet">[</span>5<span class="cite_crochet">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="En_médecine"><span id="En_m.C3.A9decine"></span>En médecine</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine_31&veaction=edit&section=2" title="Modifier la section : En médecine" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine_31&action=edit&section=2" title="Modifier le code source de la section : En médecine"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Son expression est augmentée en cas de <a href="/wiki/Dermatite_atopique" title="Dermatite atopique">dermatite atopique</a><sup id="cite_ref-Bilsborough_2006_6-0" class="reference"><a href="#cite_note-Bilsborough_2006-6"><span class="cite_crochet">[</span>6<span class="cite_crochet">]</span></a></sup>, ce qui explique le prurit. </p> <div class="mw-heading mw-heading2"><h2 id="Cible_thérapeutique"><span id="Cible_th.C3.A9rapeutique"></span>Cible thérapeutique</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine_31&veaction=edit&section=3" title="Modifier la section : Cible thérapeutique" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine_31&action=edit&section=3" title="Modifier le code source de la section : Cible thérapeutique"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Le <a href="/w/index.php?title=Nemolizumab&action=edit&redlink=1" class="new" title="Nemolizumab (page inexistante)">nemolizumab</a> est un <a href="/wiki/Anticorps_monoclonal" title="Anticorps monoclonal">anticorps monoclonal</a> dirigé contre l'interleukine 31, en cours de test, avec une efficacité sur le prurit des dermatites atopiques<sup id="cite_ref-Ruzicka_2017_7-0" class="reference"><a href="#cite_note-Ruzicka_2017-7"><span class="cite_crochet">[</span>7<span class="cite_crochet">]</span></a></sup>. </p><p>L'oclacitinib est un <a href="/wiki/Inhibiteur_de_tyrosine_kinase" title="Inhibiteur de tyrosine kinase">inhibiteur de la protéine tyrosine kinase</a> <a href="/wiki/Janus_kinase" title="Janus kinase">Jak</a> qui bloque in fine la production d'Il31, il est utilisé en dermatologie vétérinaire comme traitement symptomatique du prurit sévère dans le cadre de la dermatite atopique. </p> <div class="mw-heading mw-heading2"><h2 id="Notes_et_références"><span id="Notes_et_r.C3.A9f.C3.A9rences"></span>Notes et références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukine_31&veaction=edit&section=4" title="Modifier la section : Notes et références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Interleukine_31&action=edit&section=4" title="Modifier le code source de la section : Notes et références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-refGRCh38Ensembl_1-0">a</a> <a href="#cite_ref-refGRCh38Ensembl_1-1">b</a> et <a href="#cite_ref-refGRCh38Ensembl_1-2">c</a></sup> </span><span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000204671">GRCh38: Ensembl release 89: ENSG00000204671</a> - <a href="/wiki/Ensembl" title="Ensembl">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-refGRCm38Ensembl_2-0">a</a> <a href="#cite_ref-refGRCm38Ensembl_2-1">b</a> et <a href="#cite_ref-refGRCm38Ensembl_2-2">c</a></sup> </span><span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000029437">GRCm38: Ensembl release 89: ENSMUSG00000029437</a> - <a href="/wiki/Ensembl" title="Ensembl">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink noprint"><a href="#cite_ref-3">↑</a> </span><span class="reference-text"><span class="ouvrage">« <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=386653"><cite style="font-style:normal;">Publications PubMed pour l'Homme</cite></a> », sur <span class="italique">National Center for Biotechnology Information, U.S. National Library of Medicine</span></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink noprint"><a href="#cite_ref-4">↑</a> </span><span class="reference-text"><span class="ouvrage">« <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=76399"><cite style="font-style:normal;">Publications PubMed pour la Souris</cite></a> », sur <span class="italique">National Center for Biotechnology Information, U.S. National Library of Medicine</span></span></span> </li> <li id="cite_note-Cevikbas_2014-5"><span class="mw-cite-backlink noprint">↑ <sup><a href="#cite_ref-Cevikbas_2014_5-0">a</a> et <a href="#cite_ref-Cevikbas_2014_5-1">b</a></sup> </span><span class="reference-text">Cevikbas F, Wang X, Akiyama T et al. <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/article/pii/S0091674913017107"><i>A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1</i></a>, J Allergy Clin Immunol, 2014;133:448-460</span> </li> <li id="cite_note-Bilsborough_2006-6"><span class="mw-cite-backlink noprint"><a href="#cite_ref-Bilsborough_2006_6-0">↑</a> </span><span class="reference-text">Bilsborough J, Leung DY, Maurer M et al. <a rel="nofollow" class="external text" href="http://www.sciencedirect.com/science/article/pii/S0091674905025303"><i>IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis</i></a>, J Allergy Clin Immunol, 2006;117:418-425</span> </li> <li id="cite_note-Ruzicka_2017-7"><span class="mw-cite-backlink noprint"><a href="#cite_ref-Ruzicka_2017_7-0">↑</a> </span><span class="reference-text">Ruzicka T, Hanifin JM, Furue M et al. <a rel="nofollow" class="external text" href="http://www.nejm.org/doi/full/10.1056/NEJMoa1606490#t=abstract"><i>Anti–interleukin-31 receptor A antibody for atopic dermatitis</i></a>, N Engl J Med, 2017;376:826-835</span> </li> </ol></div> <p><br /> </p> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a href="/wiki/Portail:Biologie_cellulaire_et_mol%C3%A9culaire" title="Portail de la biologie cellulaire et moléculaire"><img alt="icône décorative" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Red2.jpg/27px-Red2.jpg" decoding="async" width="27" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Red2.jpg/40px-Red2.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/cc/Red2.jpg/53px-Red2.jpg 2x" 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