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Monday, February 17, 2025</div></section><div id="section-2" class="main-body"> <script src="/javascripts/pages/article.js?v=1739795569"></script> <div id="breadcrumbs" class="breadcrumbs"><a class="" href="/">Home</a> » <a class="" href="/topics">Topics</a> » <a class="" href="https://www.bioworld.com/topics/236-disease-categories-and-therapies">Disease categories and therapies</a> » Endocrine/metabolic</div> <div class="box1 article-topic"> <div class="records"> <h1 class="page-title"> Endocrine/metabolic <div class="rss"> <a href="/rss/topic/246-endocrine-metabolic"> <img alt="Endocrine/metabolic RSS Feed" height="16" width="16" loading="lazy" src="/images/icons/rss.gif" /> RSS </a> </div> </h1> <article class="record article-summary "> <div class="image"><a title="Seed funding at Junevity supports siRNA therapeutics for age-related diseases" class="url" rel="" target="" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases"><img width="650" height="488" alt="Illustration of siRNA structure" title="Illustration of siRNA structure" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/siRNA-structure-model.jpg?height=488&t=1732119622&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Endocrine/metabolic</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases">Seed funding at Junevity supports siRNA therapeutics for age-related diseases</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 14, 2025</div> <div class="comment-count article-summary__comment-count"><a title="Seed funding at Junevity supports siRNA therapeutics for age-related diseases" class="more" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Junevity Inc. has raised $10 million in seed funding to support its work creating silencing RNA (siRNA) therapeutics to address metabolic and age-related diseases, including type 2 diabetes, obesity and frailty. The seed funding will be used to enhance the company’s RESET platform and develop its first therapeutic candidates in these indications.<br /></div><a title="Seed funding at Junevity supports siRNA therapeutics for age-related diseases" class="more" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717259-aardvark-stock-sinks-first-day-ipo-to-fund-obesity-drugs">Aardvark stock sinks first day; IPO to fund obesity drugs</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 13, 2025</div> <div class="author article-summary__author">By <a href="/authors/43-karen-carey">Karen Carey</a></div> <div class="comment-count article-summary__comment-count"><a title="Aardvark stock sinks first day; IPO to fund obesity drugs" class="more" href="https://www.bioworld.com/articles/717259-aardvark-stock-sinks-first-day-ipo-to-fund-obesity-drugs#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Raising $94.2 million in gross proceeds, Aardvark Therapeutics Inc. became the fifth biopharma company to list on Nasdaq so far in 2025. <br /></div><a title="Aardvark stock sinks first day; IPO to fund obesity drugs" class="more" href="https://www.bioworld.com/articles/717259-aardvark-stock-sinks-first-day-ipo-to-fund-obesity-drugs">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Endocrine/metabolic</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717247-scaav9-sumf1-shows-safety-and-efficacy-as-gene-replacement-therapy-for-the-treatment-of-multiple-sulfatase-deficiency">scAAV9/SUMF1 shows safety and efficacy as gene replacement therapy for the treatment of multiple sulfatase deficiency</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 13, 2025</div> <div class="comment-count article-summary__comment-count"><a title="scAAV9/SUMF1 shows safety and efficacy as gene replacement therapy for the treatment of multiple sulfatase deficiency" class="more" href="https://www.bioworld.com/articles/717247-scaav9-sumf1-shows-safety-and-efficacy-as-gene-replacement-therapy-for-the-treatment-of-multiple-sulfatase-deficiency#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Multiple sulfatase deficiency is an autosomal recessive lysosomal storage disorder caused by homozygous or compound heterozygous loss-of-function mutations in the <em>SUMF1</em> gene, which encodes formylglycine generating enzyme (FGE), which catalyzes the post-translational modification of all known 17 sulfatases.<br /></div><a title="scAAV9/SUMF1 shows safety and efficacy as gene replacement therapy for the treatment of multiple sulfatase deficiency" class="more" href="https://www.bioworld.com/articles/717247-scaav9-sumf1-shows-safety-and-efficacy-as-gene-replacement-therapy-for-the-treatment-of-multiple-sulfatase-deficiency">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="APAC deals abound: Lilly taps Advancell, Olix; Genome draws Ellipses" class="url" rel="" target="" href="https://www.bioworld.com/articles/717211-apac-deals-abound-lilly-taps-advancell-olix-genome-draws-ellipses"><img width="650" height="488" alt="Business people with hands atop a digital globe" title="Business people with hands atop a digital globe" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Deals-and-MAs/Global-deal-merger.png?height=488&t=1588280366&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717211-apac-deals-abound-lilly-taps-advancell-olix-genome-draws-ellipses">APAC deals abound: Lilly taps Advancell, Olix; Genome draws Ellipses</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 12, 2025</div> <div class="author article-summary__author">By <a href="/authors/603-marian-yoonjee-chu">Marian (YoonJee) Chu</a></div> <div class="comment-count article-summary__comment-count"><a title="APAC deals abound: Lilly taps Advancell, Olix; Genome draws Ellipses" class="more" href="https://www.bioworld.com/articles/717211-apac-deals-abound-lilly-taps-advancell-olix-genome-draws-ellipses#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Dealmaking in the Asia Pacific (APAC) region took off this week, with the latest showcasing Genome & Co.’s licensing deal with Ellipses Pharma Ltd. for GENA-104, a phase I-ready immuno-oncology asset, under undisclosed terms Feb. 11.<br /></div><a title="APAC deals abound: Lilly taps Advancell, Olix; Genome draws Ellipses" class="more" href="https://www.bioworld.com/articles/717211-apac-deals-abound-lilly-taps-advancell-olix-genome-draws-ellipses">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Adrenomedullin pathway leads to insulin resistance in obesity " class="url" rel="" target="" href="https://www.bioworld.com/articles/717221-adrenomedullin-pathway-leads-to-insulin-resistance-in-obesity"><img width="650" height="488" alt="Illustration of insulin receptors not responding properly to insulin binding" title="Illustration of insulin receptors not responding properly to insulin binding" border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/Insulin-resistance-illustration.jpg?height=488&t=1739376976&width=650" /></a></div> <div class="article-summary__details has-image"> <div class="kicker article-summary__kicker">Endocrine/metabolic</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717221-adrenomedullin-pathway-leads-to-insulin-resistance-in-obesity">Adrenomedullin pathway leads to insulin resistance in obesity </a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 12, 2025</div> <div class="author article-summary__author">By <a href="/authors/595-mar-de-miguel">Mar de Miguel</a></div> <div class="comment-count article-summary__comment-count"><a title="Adrenomedullin pathway leads to insulin resistance in obesity " class="more" href="https://www.bioworld.com/articles/717221-adrenomedullin-pathway-leads-to-insulin-resistance-in-obesity#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Adrenomedullin, a hormone first identified in an adrenal medullary tumor, disrupts the effect of insulin on the endothelium of blood vessels, leading to insulin resistance linked to obesity and type 2 diabetes. The clue to this discovery lies in a molecular pathway that could be blocked to restore insulin function.<br /></div><a title="Adrenomedullin pathway leads to insulin resistance in obesity " class="more" href="https://www.bioworld.com/articles/717221-adrenomedullin-pathway-leads-to-insulin-resistance-in-obesity">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Olix wins $630M deal from Eli Lilly for phase I MASH asset" class="url" rel="" target="" href="https://www.bioworld.com/articles/717278-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset"><img width="650" height="488" alt="Liver illustration" title="Liver illustration " border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Liver-illustration-purple.jpg?height=488&t=1705415419&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717278-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset">Olix wins $630M deal from Eli Lilly for phase I MASH asset</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 11, 2025</div> <div class="author article-summary__author">By <a href="/authors/603-marian-yoonjee-chu">Marian (YoonJee) Chu</a></div> <div class="comment-count article-summary__comment-count"><a title="Olix wins $630M deal from Eli Lilly for phase I MASH asset" class="more" href="https://www.bioworld.com/articles/717278-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Olix Pharmaceuticals Inc. walked the talk in realizing a new $630 million licensing deal with Eli Lilly and Co. for its cardiovascular and metabolic disease asset, OLX-702A (OLX-75016), rallying stock by 30% after it had largely recovered from a terminated deal with France’s Théa Open Innovation last year.<br /></div><a title="Olix wins $630M deal from Eli Lilly for phase I MASH asset" class="more" href="https://www.bioworld.com/articles/717278-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717219-critics-of-super-bowl-rx-ad-call-for-new-playbook">Critics of Super Bowl Rx ad call for new playbook</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 10, 2025</div> <div class="author article-summary__author">By <a href="/authors/4-mari-serebrov">Mari Serebrov</a></div> <div class="comment-count article-summary__comment-count"><a title="Critics of Super Bowl Rx ad call for new playbook" class="more" href="https://www.bioworld.com/articles/717219-critics-of-super-bowl-rx-ad-call-for-new-playbook#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Amid a strengthening offensive against direct-to-consumer drug ads, two senators flagged a Super Bowl ad promoting compounded drugs as part of the company’s attack on the U.S. weight-loss industry that it said was built to keep Americans “sick and stuck.”<br /></div><a title="Critics of Super Bowl Rx ad call for new playbook" class="more" href="https://www.bioworld.com/articles/717219-critics-of-super-bowl-rx-ad-call-for-new-playbook">Read More</a> </div> </article> <article class="record article-summary "> <div class="image"><a title="Olix wins $630M deal from Eli Lilly for phase I MASH asset" class="url" rel="" target="" href="https://www.bioworld.com/articles/717092-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset"><img width="650" height="488" alt="Liver illustration" title="Liver illustration " border="0" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Gastrointestinal/Liver-illustration-purple.jpg?height=488&t=1705415419&width=650" /></a></div> <div class="article-summary__details has-image"> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717092-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset">Olix wins $630M deal from Eli Lilly for phase I MASH asset</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 10, 2025</div> <div class="author article-summary__author">By <a href="/authors/603-marian-yoonjee-chu">Marian (YoonJee) Chu</a></div> <div class="comment-count article-summary__comment-count"><a title="Olix wins $630M deal from Eli Lilly for phase I MASH asset" class="more" href="https://www.bioworld.com/articles/717092-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Olix Pharmaceuticals Inc. walked the talk in realizing a new $630 million licensing deal with Eli Lilly and Co. for its cardiovascular and metabolic disease asset, OLX-702A (OLX-75016), rallying stock by 30% after it had largely recovered from a terminated deal with France’s Théa Open Innovation last year.<br /></div><a title="Olix wins $630M deal from Eli Lilly for phase I MASH asset" class="more" href="https://www.bioworld.com/articles/717092-olix-wins-630m-deal-from-eli-lilly-for-phase-i-mash-asset">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Ocular</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717120-rbm47-a-new-target-to-watch-in-thyroid-associated-ophthalmopathy">RBM47, a new target to watch in thyroid-associated ophthalmopathy</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 10, 2025</div> <div class="comment-count article-summary__comment-count"><a title="RBM47, a new target to watch in thyroid-associated ophthalmopathy" class="more" href="https://www.bioworld.com/articles/717120-rbm47-a-new-target-to-watch-in-thyroid-associated-ophthalmopathy#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Researchers from Huazhong University of Science and Technology have described the potential use of RBM47 as a therapeutic target for thyroid-associated ophthalmopathy, an autoimmune disorder characterized by proptosis, lid swelling, diplopia and compressive optic neuropathy.<br /></div><a title="RBM47, a new target to watch in thyroid-associated ophthalmopathy" class="more" href="https://www.bioworld.com/articles/717120-rbm47-a-new-target-to-watch-in-thyroid-associated-ophthalmopathy">Read More</a> </div> </article> <article class="record article-summary "> <div class="article-summary__details "> <div class="kicker article-summary__kicker">Genetic/congenital</div> <h2 class="headline article-summary__headline"><a href="https://www.bioworld.com/articles/717116-new-prophylactic-immunomodulation-for-upcoming-4d-310-trials-presented">New prophylactic immunomodulation for upcoming 4D-310 trials presented</a></h2> <div class="post-meta"> <div class="date article-summary__post-date">Feb. 10, 2025</div> <div class="comment-count article-summary__comment-count"><a title="New prophylactic immunomodulation for upcoming 4D-310 trials presented" class="more" href="https://www.bioworld.com/articles/717116-new-prophylactic-immunomodulation-for-upcoming-4d-310-trials-presented#comments-container">No Comments</a></div> </div> <div class="abstract article-summary__teaser">Fabry disease is an X-linked lysosomal storage disorder caused by a deficiency of the enzyme α-galactosidase A (GLA), which leads to complex multisystemic involvement, with the majority of patients developing hypertrophic cardiomyopathy.<br 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