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Autosome - Wikipedia
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Available in 51 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-51" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">51 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%B5%D8%A8%D8%BA%D9%8A_%D8%AC%D8%B3%D9%85%D9%8A" title="صبغي جسمي – Arabic" lang="ar" hreflang="ar" data-title="صبغي جسمي" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%85%E0%A6%9F%E0%A7%8B%E0%A6%9C%E0%A7%8B%E0%A6%AE" title="অটোজোম – Bangla" lang="bn" hreflang="bn" data-title="অটোজোম" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-zh-min-nan mw-list-item"><a href="https://zh-min-nan.wikipedia.org/wiki/Si%C3%B4ng-ji%C3%A1m-sek-th%C3%A9" title="Siông-jiám-sek-thé – Minnan" lang="nan" hreflang="nan" data-title="Siông-jiám-sek-thé" data-language-autonym="閩南語 / Bân-lâm-gú" data-language-local-name="Minnan" class="interlanguage-link-target"><span>閩南語 / Bân-lâm-gú</span></a></li><li class="interlanguage-link interwiki-ba mw-list-item"><a href="https://ba.wikipedia.org/wiki/%D0%90%D1%83%D1%82%D0%BE%D1%81%D0%BE%D0%BC%D0%B0" title="Аутосома – Bashkir" lang="ba" hreflang="ba" data-title="Аутосома" data-language-autonym="Башҡортса" data-language-local-name="Bashkir" class="interlanguage-link-target"><span>Башҡортса</span></a></li><li class="interlanguage-link interwiki-be mw-list-item"><a href="https://be.wikipedia.org/wiki/%D0%90%D1%9E%D1%82%D0%B0%D1%81%D0%BE%D0%BC%D0%B0" title="Аўтасома – Belarusian" lang="be" hreflang="be" data-title="Аўтасома" data-language-autonym="Беларуская" data-language-local-name="Belarusian" class="interlanguage-link-target"><span>Беларуская</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%90%D0%B2%D1%82%D0%BE%D0%B7%D0%BE%D0%BC" title="Автозом – Bulgarian" lang="bg" hreflang="bg" data-title="Автозом" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Autosom" title="Autosom – Bosnian" lang="bs" hreflang="bs" data-title="Autosom" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Autosoma" title="Autosoma – Catalan" lang="ca" hreflang="ca" data-title="Autosoma" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Autozom" title="Autozom – Czech" lang="cs" hreflang="cs" data-title="Autozom" data-language-autonym="Čeština" data-language-local-name="Czech" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Autosom" title="Autosom – Danish" lang="da" hreflang="da" data-title="Autosom" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Autosom" title="Autosom – German" lang="de" hreflang="de" data-title="Autosom" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Autosoom" title="Autosoom – Estonian" lang="et" hreflang="et" data-title="Autosoom" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%91%CF%85%CF%84%CE%BF%CF%83%CF%89%CE%BC%CE%B9%CE%BA%CF%8C_%CF%87%CF%81%CF%89%CE%BC%CF%8C%CF%83%CF%89%CE%BC%CE%B1" title="Αυτοσωμικό χρωμόσωμα – Greek" lang="el" hreflang="el" data-title="Αυτοσωμικό χρωμόσωμα" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Autosoma" title="Autosoma – Spanish" lang="es" hreflang="es" data-title="Autosoma" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/A%C5%ADtosomo" title="Aŭtosomo – Esperanto" lang="eo" hreflang="eo" data-title="Aŭtosomo" data-language-autonym="Esperanto" data-language-local-name="Esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Autosoma" title="Autosoma – Basque" lang="eu" hreflang="eu" data-title="Autosoma" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%D8%AA%D9%88%D8%B2%D9%88%D9%85" title="اتوزوم – Persian" lang="fa" hreflang="fa" data-title="اتوزوم" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Autosome" title="Autosome – French" lang="fr" hreflang="fr" data-title="Autosome" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Uaths%C3%B3im" title="Uathsóim – Irish" lang="ga" hreflang="ga" data-title="Uathsóim" data-language-autonym="Gaeilge" data-language-local-name="Irish" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Autosoma" title="Autosoma – Galician" lang="gl" hreflang="gl" data-title="Autosoma" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%83%81%EC%97%BC%EC%83%89%EC%B2%B4" title="상염색체 – Korean" lang="ko" hreflang="ko" data-title="상염색체" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%B1%D5%B8%D6%82%D5%BF%D5%B8%D5%BD%D5%B8%D5%B4" title="Աուտոսոմ – Armenian" lang="hy" hreflang="hy" data-title="Աուտոսոմ" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Autosom" title="Autosom – Croatian" lang="hr" hreflang="hr" data-title="Autosom" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-is mw-list-item"><a href="https://is.wikipedia.org/wiki/Samlitningur" title="Samlitningur – Icelandic" lang="is" hreflang="is" data-title="Samlitningur" data-language-autonym="Íslenska" data-language-local-name="Icelandic" class="interlanguage-link-target"><span>Íslenska</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Autosoma" title="Autosoma – Italian" lang="it" hreflang="it" data-title="Autosoma" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%95%D7%98%D7%95%D7%96%D7%95%D7%9D" title="אוטוזום – Hebrew" lang="he" hreflang="he" data-title="אוטוזום" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%90%D1%83%D1%82%D0%BE%D1%81%D0%BE%D0%BC%D0%B0%D0%BB%D0%B0%D1%80" title="Аутосомалар – Kazakh" lang="kk" hreflang="kk" data-title="Аутосомалар" data-language-autonym="Қазақша" data-language-local-name="Kazakh" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ht mw-list-item"><a href="https://ht.wikipedia.org/wiki/Otoz%C3%B2m" title="Otozòm – Haitian Creole" lang="ht" hreflang="ht" data-title="Otozòm" data-language-autonym="Kreyòl ayisyen" data-language-local-name="Haitian Creole" class="interlanguage-link-target"><span>Kreyòl ayisyen</span></a></li><li class="interlanguage-link interwiki-ku mw-list-item"><a href="https://ku.wikipedia.org/wiki/Otozom" title="Otozom – Kurdish" lang="ku" hreflang="ku" data-title="Otozom" data-language-autonym="Kurdî" data-language-local-name="Kurdish" class="interlanguage-link-target"><span>Kurdî</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Autosoma" title="Autosoma – Lithuanian" lang="lt" hreflang="lt" data-title="Autosoma" data-language-autonym="Lietuvių" data-language-local-name="Lithuanian" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Autosz%C3%B3ma" title="Autoszóma – Hungarian" lang="hu" hreflang="hu" data-title="Autoszóma" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Autosoom" title="Autosoom – Dutch" lang="nl" hreflang="nl" data-title="Autosoom" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E5%B8%B8%E6%9F%93%E8%89%B2%E4%BD%93" title="常染色体 – Japanese" lang="ja" hreflang="ja" data-title="常染色体" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Autosom" title="Autosom – Norwegian Bokmål" lang="nb" hreflang="nb" data-title="Autosom" data-language-autonym="Norsk bokmål" data-language-local-name="Norwegian Bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Autosomy" title="Autosomy – Polish" lang="pl" hreflang="pl" data-title="Autosomy" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Autossomo" title="Autossomo – Portuguese" lang="pt" hreflang="pt" data-title="Autossomo" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Autozom" title="Autozom – Romanian" lang="ro" hreflang="ro" data-title="Autozom" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D1%83%D1%82%D0%BE%D1%81%D0%BE%D0%BC%D0%B0" title="Аутосома – Russian" lang="ru" hreflang="ru" data-title="Аутосома" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Avtosom" title="Avtosom – Slovenian" lang="sl" hreflang="sl" data-title="Avtosom" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%D9%84%DB%95%D8%B4%DB%95%DA%A9%DA%95%DB%86%D9%85%DB%86%D8%B3%DB%86%D9%85" title="لەشەکڕۆمۆسۆم – Central Kurdish" lang="ckb" hreflang="ckb" data-title="لەشەکڕۆمۆسۆم" data-language-autonym="کوردی" data-language-local-name="Central Kurdish" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%90%D1%83%D1%82%D0%BE%D0%B7%D0%BE%D0%BC" title="Аутозом – Serbian" lang="sr" hreflang="sr" data-title="Аутозом" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Autosom" title="Autosom – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Autosom" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Autosomi" title="Autosomi – Finnish" lang="fi" hreflang="fi" data-title="Autosomi" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Autosom" title="Autosom – Swedish" lang="sv" hreflang="sv" data-title="Autosom" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%A4%E0%AE%A9%E0%AF%8D%E0%AE%A8%E0%AE%BF%E0%AE%B1%E0%AE%AA%E0%AF%8D%E0%AE%AA%E0%AF%81%E0%AE%B0%E0%AE%BF" title="தன்நிறப்புரி – Tamil" lang="ta" hreflang="ta" data-title="தன்நிறப்புரி" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B8%AD%E0%B8%AD%E0%B9%82%E0%B8%95%E0%B9%82%E0%B8%8B%E0%B8%A1" title="ออโตโซม – Thai" lang="th" hreflang="th" data-title="ออโตโซม" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Otozomlar" title="Otozomlar – Turkish" lang="tr" hreflang="tr" data-title="Otozomlar" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D0%B2%D1%82%D0%BE%D1%81%D0%BE%D0%BC%D0%B0" title="Автосома – Ukrainian" lang="uk" hreflang="uk" data-title="Автосома" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Nhi%E1%BB%85m_s%E1%BA%AFc_th%E1%BB%83_th%C6%B0%E1%BB%9Dng" title="Nhiễm sắc thể thường – Vietnamese" lang="vi" hreflang="vi" data-title="Nhiễm sắc thể thường" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh-classical mw-list-item"><a href="https://zh-classical.wikipedia.org/wiki/%E5%B8%B8%E6%9F%93%E8%89%B2%E9%AB%94" title="常染色體 – Literary Chinese" lang="lzh" hreflang="lzh" data-title="常染色體" data-language-autonym="文言" data-language-local-name="Literary Chinese" class="interlanguage-link-target"><span>文言</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%B8%B8%E6%9F%93%E8%89%B2%E4%BD%93" title="常染色体 – Chinese" lang="zh" hreflang="zh" data-title="常染色体" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q186380#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Autosome" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Autosome" rel="discussion" title="Discuss improvements to the content page 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class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Any chromosome other than a sex chromosome</div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">This article is about a type of chromosome. For the ancestral discovery method using autosomal DNA, see <a href="/wiki/Genealogical_DNA_test#Geographic_origin_tests" title="Genealogical DNA test">Genealogical DNA test § Geographic origin tests</a>.</div> <p>An <b>autosome</b> is any <a href="/wiki/Chromosome" title="Chromosome">chromosome</a> that is not a <a href="/wiki/Sex_chromosome" title="Sex chromosome">sex chromosome</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> The members of an autosome pair in a <a href="/wiki/Diploid" class="mw-redirect" title="Diploid">diploid</a> cell have the same <a href="/wiki/Morphology_(biology)" title="Morphology (biology)">morphology</a>, unlike those in <a href="/wiki/Allosome" class="mw-redirect" title="Allosome">allosomal</a> (<a href="/wiki/Sex_chromosome" title="Sex chromosome">sex chromosome</a>) pairs, which may have different structures. The <a href="/wiki/DNA" title="DNA">DNA</a> in autosomes is collectively known as <b>atDNA</b> or <b>auDNA</b>.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>For example, <a href="/wiki/Human" title="Human">humans</a> have <a href="/wiki/Human_genome" title="Human genome">a diploid genome</a> that usually contains 22 pairs of autosomes and one <a href="/wiki/Allosome" class="mw-redirect" title="Allosome">allosome</a> pair (46 chromosomes total). The autosome pairs are labeled with numbers (1–22 in humans) roughly in order of their sizes in base pairs, while allosomes are labelled with their letters.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> By contrast, the allosome pair consists of two <a href="/wiki/X_chromosome" title="X chromosome">X chromosomes</a> in females or one X and one <a href="/wiki/Y_chromosome" title="Y chromosome">Y chromosome</a> in males. Unusual combinations <a href="/wiki/XYY_syndrome" title="XYY syndrome">XYY</a>, <a href="/wiki/Klinefelter_syndrome" title="Klinefelter syndrome">XXY</a>, <a href="/wiki/Triple_X_syndrome" class="mw-redirect" title="Triple X syndrome">XXX</a>, <a href="/wiki/XXXX_syndrome" class="mw-redirect" title="XXXX syndrome">XXXX</a>, <a href="/wiki/XXXXX_syndrome" class="mw-redirect" title="XXXXX syndrome">XXXXX</a> or <a href="/wiki/XXYY_syndrome" title="XXYY syndrome">XXYY</a>, among other irregular combinations, are known to occur and usually cause developmental abnormalities. </p><p>Autosomes still contain sexual determination <a href="/wiki/Genes" class="mw-redirect" title="Genes">genes</a> even though they are not sex chromosomes. For example, the <a href="/wiki/SRY" class="mw-redirect" title="SRY">SRY</a> gene on the Y chromosome encodes the transcription factor <a href="/wiki/Testis_determining_factor" class="mw-redirect" title="Testis determining factor">TDF</a> and is vital for male sex determination during development. TDF functions by activating the <a href="/wiki/SOX9" title="SOX9">SOX9</a> gene on <a href="/wiki/Chromosome_17_(human)" class="mw-redirect" title="Chromosome 17 (human)">chromosome 17</a>, so mutations of the <a href="/wiki/SOX9" title="SOX9">SOX9</a> gene can cause humans with an ordinary Y chromosome to develop as females.<sup id="cite_ref-pmid7990924_4-0" class="reference"><a href="#cite_note-pmid7990924-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>All human autosomes have been identified and mapped by extracting the chromosomes from a cell arrested in <a href="/wiki/Metaphase" title="Metaphase">metaphase</a> or <a href="/wiki/Prometaphase" title="Prometaphase">prometaphase</a> and then staining them with a type of dye (most commonly, <a href="/wiki/Giemsa_stain" title="Giemsa stain">Giemsa</a>).<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> These chromosomes are typically viewed as <a href="/wiki/Karyogram" class="mw-redirect" title="Karyogram">karyograms</a> for easy comparison. Clinical geneticists can compare the karyogram of an individual to a reference karyogram to discover the cytogenetic basis of certain <a href="/wiki/Phenotype" title="Phenotype">phenotypes</a>. For example, the karyogram of someone with <a href="/wiki/Patau_syndrome" title="Patau syndrome">Patau Syndrome</a> would show that they possess three copies of <a href="/wiki/Chromosome_13_(human)" class="mw-redirect" title="Chromosome 13 (human)">chromosome 13</a>. Karyograms and staining techniques can only detect large-scale disruptions to chromosomes—chromosomal aberrations smaller than a few million base pairs generally cannot be seen on a karyogram.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <table class="wikitable" style="width: 75%; margin: 1em auto 1em auto;"> <tbody><tr> <th colspan="2"><a href="/wiki/Karyotype" title="Karyotype">Karyotype</a> of human chromosomes </th></tr> <tr> <td align="center">Female (XX) </td> <td align="center">Male (XY) </td></tr> <tr> <td><figure class="mw-halign-center" typeof="mw:File"><a href="/wiki/File:PLoSBiol3.5.Fig7ChromosomesAluFish.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/27/PLoSBiol3.5.Fig7ChromosomesAluFish.jpg/420px-PLoSBiol3.5.Fig7ChromosomesAluFish.jpg" decoding="async" width="420" height="115" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/27/PLoSBiol3.5.Fig7ChromosomesAluFish.jpg/630px-PLoSBiol3.5.Fig7ChromosomesAluFish.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/27/PLoSBiol3.5.Fig7ChromosomesAluFish.jpg/840px-PLoSBiol3.5.Fig7ChromosomesAluFish.jpg 2x" data-file-width="2346" data-file-height="640" /></a><figcaption></figcaption></figure> </td> <td><figure class="mw-halign-center" typeof="mw:File"><a href="/wiki/File:Human_male_karyotype.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fd/Human_male_karyotype.gif/331px-Human_male_karyotype.gif" decoding="async" width="331" height="258" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/f/fd/Human_male_karyotype.gif 1.5x" data-file-width="424" data-file-height="331" /></a><figcaption></figcaption></figure> </td></tr> <tr> <td colspan="2">There are two copies of each <b>autosome</b> (chromosomes 1–22) in both females and males. The <b>sex chromosomes</b> are different: There are two copies of the X-chromosome in females, but males have a single X-chromosome and a Y-chromosome. </td></tr></tbody></table> <div class="mw-heading mw-heading2"><h2 id="Autosomal_genetic_disorders">Autosomal genetic disorders</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Autosome&action=edit&section=1" title="Edit section: Autosomal genetic disorders"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Autosomal_recessive_inheritance.gif" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/a/a0/Autosomal_recessive_inheritance.gif" decoding="async" width="206" height="218" class="mw-file-element" data-file-width="206" data-file-height="218" /></a><figcaption>An illustration of the inheritance pattern and phenotypic effects of an autosomal recessive gene.</figcaption></figure> <p>Autosomal genetic disorders can arise due to a number of causes, some of the most common being <a href="/wiki/Nondisjunction" title="Nondisjunction">nondisjunction</a> in parental germ cells or <a href="/wiki/Mendelian_inheritance" title="Mendelian inheritance">Mendelian inheritance</a> of deleterious alleles from parents. Autosomal genetic disorders which exhibit Mendelian inheritance can be inherited either in an <a href="/wiki/Autosomal_dominant" class="mw-redirect" title="Autosomal dominant">autosomal dominant</a> or recessive fashion.<sup id="cite_ref-:0_7-0" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> These disorders manifest in and are passed on by either sex with equal frequency.<sup id="cite_ref-:0_7-1" class="reference"><a href="#cite_note-:0-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Autosomal dominant disorders are often present in both parent and child, as the child needs to inherit only one copy of the deleterious <a href="/wiki/Allele" title="Allele">allele</a> to manifest the disease. Autosomal recessive diseases, however, require two copies of the deleterious allele for the disease to manifest. Because it is possible to possess one copy of a deleterious allele without presenting a disease phenotype, two phenotypically normal parents can have a child with the disease if both parents are carriers (also known as <a href="/wiki/Heterozygote" class="mw-redirect" title="Heterozygote">heterozygotes</a>) for the condition. </p><p>Autosomal <a href="/wiki/Aneuploidy" title="Aneuploidy">aneuploidy</a> can also result in disease conditions. Aneuploidy of autosomes is not well tolerated and usually results in miscarriage of the developing fetus. Fetuses with aneuploidy of gene-rich chromosomes—such as <a href="/wiki/Chromosome_1_(human)" class="mw-redirect" title="Chromosome 1 (human)">chromosome 1</a>—never survive to term,<sup id="cite_ref-:1_9-0" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> and fetuses with aneuploidy of gene-poor chromosomes—such as <a href="/wiki/Chromosome_21_(human)" class="mw-redirect" title="Chromosome 21 (human)">chromosome 21</a>— are still miscarried over 23% of the time.<sup id="cite_ref-pmid16634111_10-0" class="reference"><a href="#cite_note-pmid16634111-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Possessing a single copy of an autosome (known as a monosomy) is nearly always incompatible with life, though very rarely some monosomies can survive past birth. Having three copies of an autosome (known as a trisomy) is far more compatible with life, however. A common example is <a href="/wiki/Down_syndrome" title="Down syndrome">Down syndrome</a>, which is caused by possessing three copies of <a href="/wiki/Chromosome_21_(human)" class="mw-redirect" title="Chromosome 21 (human)">chromosome 21</a> instead of the usual two.<sup id="cite_ref-:1_9-1" class="reference"><a href="#cite_note-:1-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Partial aneuploidy can also occur as a result of <a href="/wiki/Chromosomal_translocation" title="Chromosomal translocation">unbalanced translocations</a> during meiosis.<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Deletions of part of a chromosome cause partial monosomies, while duplications can cause partial trisomies. If the duplication or deletion is large enough, it can be discovered by analyzing a karyogram of the individual. Autosomal translocations can be responsible for a number of diseases, ranging from <a href="/wiki/Cancer" title="Cancer">cancer</a> to <a href="/wiki/Schizophrenia" title="Schizophrenia">schizophrenia</a>.<sup id="cite_ref-pmid19556891_12-0" class="reference"><a href="#cite_note-pmid19556891-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11973326_13-0" class="reference"><a href="#cite_note-pmid11973326-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Unlike single gene disorders, diseases caused by aneuploidy are the result of improper <a href="/wiki/Gene_dosage" title="Gene dosage">gene dosage</a>, not nonfunctional gene product.<sup id="cite_ref-pmid22974302_14-0" class="reference"><a href="#cite_note-pmid22974302-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Autosome&action=edit&section=2" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Aneuploidy" title="Aneuploidy">Aneuploidy</a> (abnormal number of chromosomes)</li> <li><a href="/wiki/Autosomal_dominant" class="mw-redirect" title="Autosomal dominant">Autosomal dominant</a></li> <li><a href="/wiki/Autosomal_recessive" class="mw-redirect" title="Autosomal recessive">Autosomal recessive</a></li> <li><a href="/wiki/Homologous_chromosome" title="Homologous chromosome">Homologous chromosome</a></li> <li><a href="/wiki/Pseudoautosomal_region" title="Pseudoautosomal region">Pseudoautosomal region</a></li> <li><a href="/wiki/XY_sex-determination_system" title="XY sex-determination system">XY sex-determination system</a></li> <li><a href="/wiki/Genetic_disorder" title="Genetic disorder">Genetic disorder</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Autosome&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output 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.id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFGriffiths1999" class="citation book cs1">Griffiths, Anthony J. F. (1999). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/bv.fcgi?highlight=autosome&rid=iga.section.222"><i>An Introduction to genetic analysis</i></a>. New York: W.H. Freeman. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-7167-3771-1" title="Special:BookSources/978-0-7167-3771-1"><bdi>978-0-7167-3771-1</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=An+Introduction+to+genetic+analysis&rft.place=New+York&rft.pub=W.H.+Freeman&rft.date=1999&rft.isbn=978-0-7167-3771-1&rft.aulast=Griffiths&rft.aufirst=Anthony+J.+F.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fbooks%2Fbv.fcgi%3Fhighlight%3Dautosome%26rid%3Diga.section.222&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAutosome" class="Z3988"></span></span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-2">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.isogg.org/wiki/Autosomal_DNA">"Autosomal DNA - ISOGG Wiki"</a>. <i>www.isogg.org</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170821085342/https://isogg.org/wiki/Autosomal_DNA">Archived</a> from the original on 21 August 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">28 April</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.isogg.org&rft.atitle=Autosomal+DNA+-+ISOGG+Wiki&rft_id=http%3A%2F%2Fwww.isogg.org%2Fwiki%2FAutosomal_DNA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAutosome" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20160102070828/http://ghr.nlm.nih.gov/glossary=autosome">"Autosome Definition(s)"</a>. <i>Genetics Home Reference</i>. Archived from <a rel="nofollow" class="external text" href="http://ghr.nlm.nih.gov/glossary=autosome">the original</a> on 2 January 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">28 April</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Genetics+Home+Reference&rft.atitle=Autosome+Definition%28s%29&rft_id=http%3A%2F%2Fghr.nlm.nih.gov%2Fglossary%3Dautosome&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAutosome" class="Z3988"></span></span> </li> <li id="cite_note-pmid7990924-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid7990924_4-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFosterDominguez-SteglichGuioliKwok1994" class="citation journal cs1">Foster JW, Dominguez-Steglich MA, Guioli S, Kwok C, Weller PA, Stevanović M, Weissenbach J, Mansour S, Young ID, Goodfellow PN (December 1994). "Complicate dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene". <i>Nature</i>. <b>372</b> (6506): 525–30. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1994Natur.372..525F">1994Natur.372..525F</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F372525a0">10.1038/372525a0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7990924">7990924</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:1472426">1472426</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Complicate+dysplasia+and+autosomal+sex+reversal+caused+by+mutations+in+an+SRY-related+gene&rft.volume=372&rft.issue=6506&rft.pages=525-30&rft.date=1994-12&rft_id=info%3Adoi%2F10.1038%2F372525a0&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A1472426%23id-name%3DS2CID&rft_id=info%3Apmid%2F7990924&rft_id=info%3Abibcode%2F1994Natur.372..525F&rft.aulast=Foster&rft.aufirst=JW&rft.au=Dominguez-Steglich%2C+MA&rft.au=Guioli%2C+S&rft.au=Kwok%2C+C&rft.au=Weller%2C+PA&rft.au=Stevanovi%C4%87%2C+M&rft.au=Weissenbach%2C+J&rft.au=Mansour%2C+S&rft.au=Young%2C+ID&rft.au=Goodfellow%2C+PN&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAutosome" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.encyclopedia.com/topic/Chromosome_mapping.aspx">"Chromosome mapping Facts, information, pictures"</a>. <i>encyclopedia.com</i>. Encyclopedia.com articles about Chromosome mapping. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20151210220706/http://www.encyclopedia.com/topic/Chromosome_mapping.aspx">Archived</a> from the original on 10 December 2015<span class="reference-accessdate">. Retrieved <span class="nowrap">4 December</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=encyclopedia.com&rft.atitle=Chromosome+mapping+Facts%2C+information%2C+pictures&rft_id=http%3A%2F%2Fwww.encyclopedia.com%2Ftopic%2FChromosome_mapping.aspx&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAutosome" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNussbaumMcInnesWillardHamosh2007" class="citation book cs1">Nussbaum RL, McInnes RR, Willard HF, Hamosh A, Thompson MW (2007). <span class="id-lock-limited" title="Free access subject to limited trial, subscription normally required"><a rel="nofollow" class="external text" href="https://archive.org/details/thompsonthompson00nuss"><i>Thompson & Thompson Genetics in Medicine</i></a></span> (7th ed.). Philadelphia, PA: Saunders/Elsevier. p. <a rel="nofollow" class="external text" href="https://archive.org/details/thompsonthompson00nuss/page/n68">69</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9781416030805" title="Special:BookSources/9781416030805"><bdi>9781416030805</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Thompson+%26+Thompson+Genetics+in+Medicine&rft.place=Philadelphia%2C+PA&rft.pages=69&rft.edition=7th&rft.pub=Saunders%2FElsevier&rft.date=2007&rft.isbn=9781416030805&rft.aulast=Nussbaum&rft.aufirst=RL&rft.au=McInnes%2C+RR&rft.au=Willard%2C+HF&rft.au=Hamosh%2C+A&rft.au=Thompson%2C+MW&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fthompsonthompson00nuss&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAutosome" class="Z3988"></span></span> </li> <li id="cite_note-:0-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-:0_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-:0_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.britannica.com/science/human-genetic-disease">"human genetic disease"</a>. <i>Encyclopædia Britannica</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20151013183225/https://www.britannica.com/science/human-genetic-disease">Archived</a> from the original on 2015-10-13<span class="reference-accessdate">. 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(2005-01-01). "Autosomal Aneuploidy". In Gersen, Steven L.; MEd, Martha B. Keagle (eds.). <i>The Principles of Clinical Cytogenetics</i>. 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(15 December 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767307">"Dosage Compensation of the Sex Chromosomes"</a>. <i>Annual Review of Genetics</i>. <b>46</b> (1): 537–560. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1146%2Fannurev-genet-110711-155454">10.1146/annurev-genet-110711-155454</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767307">3767307</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22974302">22974302</a>.</cite><span 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href="/wiki/Template:Chromosome_genetics" title="Template:Chromosome genetics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Chromosome_genetics" title="Template talk:Chromosome genetics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Chromosome_genetics" title="Special:EditPage/Template:Chromosome genetics"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cytogenetics:_chromosomes" style="font-size:114%;margin:0 4em"><a href="/wiki/Cytogenetics" title="Cytogenetics">Cytogenetics</a>: <a href="/wiki/Chromosome" title="Chromosome">chromosomes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Basic<br />concepts</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Karyotype" title="Karyotype">Karyotype</a></li> <li><a href="/wiki/Ploidy" title="Ploidy">Ploidy</a></li> <li><a href="/wiki/Genome" title="Genome">Genetic material</a>/<a href="/wiki/Genome" title="Genome">Genome</a></li> <li><a href="/wiki/Chromatin" title="Chromatin">Chromatin</a> <ul><li><a href="/wiki/Euchromatin" title="Euchromatin">Euchromatin</a></li> <li><a href="/wiki/Heterochromatin" title="Heterochromatin">Heterochromatin</a></li></ul></li> <li><a href="/wiki/Chromosome" title="Chromosome">Chromosome</a></li> <li><a href="/wiki/Chromatid" title="Chromatid">Chromatid</a></li> <li><a href="/wiki/Nucleosome" title="Nucleosome">Nucleosome</a></li> <li><a href="/wiki/Nuclear_organization" title="Nuclear organization">Nuclear organization</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Autosome</a>/<a href="/wiki/Sex-determination_system" title="Sex-determination system">Sex chromosome</a> (or <a href="/wiki/Sex_chromosome" title="Sex chromosome">allosome</a> or heterosome)</li> <li><a href="/wiki/Microchromosome" title="Microchromosome">Macrochromosome/Microchromosome</a></li> <li><a href="/wiki/Circular_bacterial_chromosome" class="mw-redirect" title="Circular bacterial chromosome">Circular chromosome</a>/<a href="/wiki/Linear_chromosome" title="Linear chromosome">Linear chromosome</a></li> <li><a href="/wiki/Aneuploidy" title="Aneuploidy">Extra chromosome</a> (or accessory chromosome)</li> <li><a href="/wiki/Small_supernumerary_marker_chromosome" title="Small supernumerary marker chromosome">Supernumerary chromosome</a></li> <li><a href="/wiki/B_chromosome" title="B chromosome">A chromosome/B chromosome</a></li> <li><a href="/wiki/Lampbrush_chromosome" title="Lampbrush chromosome">Lampbrush chromosome</a></li> <li><a href="/wiki/Polytene_chromosome" title="Polytene chromosome">Polytene chromosome</a></li> <li><a href="/wiki/Dinokaryon" title="Dinokaryon">Dinoflagellate chromosomes</a></li> <li><a href="/wiki/Homologous_chromosome" title="Homologous chromosome">Homologous chromosome</a></li> <li><a href="/wiki/Isochromosome" title="Isochromosome">Isochromosome</a></li> <li><a href="/wiki/Satellite_chromosome" title="Satellite chromosome">Satellite chromosome</a></li> <li><i>Centromere position</i> <ul><li><a href="/wiki/Centromere#Metacentric" title="Centromere">Metacentric</a></li> <li><a href="/wiki/Submetacentric" class="mw-redirect" title="Submetacentric">Submetacentric</a></li> <li><a href="/wiki/Telocentric" class="mw-redirect" title="Telocentric">Telocentric</a></li> <li><a href="/wiki/Acrocentric" class="mw-redirect" title="Acrocentric">Acrocentric</a></li> <li><a href="/wiki/Holocentric_chromosome" title="Holocentric chromosome">Holocentric</a></li></ul></li> <li><i>Centromere number</i> <ul><li><a href="/wiki/Acentric_fragment" title="Acentric fragment">Acentric</a></li> <li><a href="/wiki/Monocentric" class="mw-redirect" title="Monocentric">Monocentric</a></li> <li><a href="/wiki/Dicentric_chromosome" title="Dicentric chromosome">Dicentric</a></li> <li><a href="/wiki/Polycentric_chromosome" title="Polycentric chromosome">Polycentric</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Processes<br />and evolution</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mitosis" title="Mitosis">Mitosis</a></li> <li><a href="/wiki/Meiosis" title="Meiosis">Meiosis</a></li> <li><a href="/wiki/Chromosome_abnormality#Structural_abnormalities" title="Chromosome abnormality">Structural alterations</a> <ul><li><a href="/wiki/Chromosomal_inversion" title="Chromosomal inversion">Chromosomal inversion</a></li> <li><a href="/wiki/Chromosomal_translocation" title="Chromosomal translocation">Chromosomal translocation</a></li></ul></li> <li><a href="/wiki/Chromosome_abnormality#Numerical_disorders" title="Chromosome abnormality">Numerical alterations</a> <ul><li><a href="/wiki/Aneuploidy" title="Aneuploidy">Aneuploidy</a></li> <li><a href="/wiki/Ploidy" title="Ploidy">Euploidy</a></li> <li><a href="/wiki/Polyploidy" title="Polyploidy">Polyploidy</a></li> <li><a href="/wiki/Paleopolyploidy" title="Paleopolyploidy">Paleopolyploidy</a></li></ul></li> <li><a href="/wiki/Polyploidization" class="mw-redirect" title="Polyploidization">Polyploidization</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Structures</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Telomere" title="Telomere">Telomere</a>: <a href="/wiki/Telomere-binding_protein" title="Telomere-binding protein">Telomere-binding protein</a> (<a href="/wiki/TINF2" title="TINF2">TINF2</a>)</li> <li><a href="/wiki/Protamine" title="Protamine">Protamine</a></li></ul> </div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Histone" title="Histone">Histone</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Histone_H1" title="Histone H1">H1</a></li> <li><a href="/wiki/Histone_H2A" title="Histone H2A">H2A</a></li> <li><a href="/wiki/Histone_H2B" title="Histone H2B">H2B</a></li> <li><a href="/wiki/Histone_H3" title="Histone H3">H3</a></li> <li><a href="/wiki/Histone_H4" title="Histone H4">H4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Centromere" title="Centromere">Centromere</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CENPA" title="CENPA">A</a></li> <li><a href="/wiki/Centromere_protein_B" title="Centromere protein B">B</a></li> <li><a href="/wiki/CENPC1" title="CENPC1">C1</a></li> <li><a href="/w/index.php?title=CENPC2&action=edit&redlink=1" class="new" title="CENPC2 (page does not exist)">C2</a></li> <li><a href="/wiki/Centromere_protein_E" title="Centromere protein E">E</a></li> <li><a href="/wiki/CENPF" title="CENPF">F</a></li> <li><a href="/wiki/CENPH" title="CENPH">H</a></li> <li><a href="/wiki/CENPI" title="CENPI">I</a></li> <li><a href="/wiki/CENPJ" title="CENPJ">J</a></li> <li><a href="/wiki/CENPK" title="CENPK">K</a></li> <li><a href="/wiki/CENPM" title="CENPM">M</a></li> <li><a href="/wiki/CENPN" title="CENPN">N</a></li> <li><a href="/wiki/CENPO" title="CENPO">O</a></li> <li><a href="/w/index.php?title=CENPP&action=edit&redlink=1" class="new" title="CENPP (page does not exist)">P</a></li> <li><a href="/w/index.php?title=CENPQ&action=edit&redlink=1" class="new" title="CENPQ (page does not exist)">Q</a></li> <li><a href="/wiki/CENPT" title="CENPT">T</a></li></ul> </div></td></tr></tbody></table><div> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">See also</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Extrachromosomal_DNA" title="Extrachromosomal DNA">Extrachromosomal DNA</a> <ul><li><a href="/wiki/Plasmid" title="Plasmid">Plasmid</a></li></ul></li> <li><a href="/wiki/List_of_organisms_by_chromosome_count" title="List of organisms by chromosome count">List of organisms by chromosome count</a></li> <li><a href="/wiki/List_of_sequenced_eukaryotic_genomes" title="List of sequenced eukaryotic genomes">List of sequenced genomes</a></li> <li><a href="/wiki/International_System_for_Human_Cytogenetic_Nomenclature" class="mw-redirect" title="International System for Human Cytogenetic Nomenclature">International System for Human Cytogenetic Nomenclature</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Human_genome" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Chromosomes" title="Template:Chromosomes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Chromosomes" title="Template talk:Chromosomes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Chromosomes" title="Special:EditPage/Template:Chromosomes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Human_genome" style="font-size:114%;margin:0 4em"><a href="/wiki/Human_genome" title="Human genome">Human genome</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Nuclear_DNA" title="Nuclear DNA">Nuclear genome</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a class="mw-selflink selflink">Autosome</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chromosome_1" title="Chromosome 1">1</a></li> <li><a href="/wiki/Chromosome_2" title="Chromosome 2">2</a></li> <li><a href="/wiki/Chromosome_3" title="Chromosome 3">3</a></li> <li><a href="/wiki/Chromosome_4" title="Chromosome 4">4</a></li> <li><a href="/wiki/Chromosome_5" title="Chromosome 5">5</a></li> <li><a href="/wiki/Chromosome_6" title="Chromosome 6">6</a></li> <li><a href="/wiki/Chromosome_7" title="Chromosome 7">7</a></li> <li><a href="/wiki/Chromosome_8" title="Chromosome 8">8</a></li> <li><a href="/wiki/Chromosome_9" title="Chromosome 9">9</a></li> <li><a href="/wiki/Chromosome_10" title="Chromosome 10">10</a></li> <li><a href="/wiki/Chromosome_11" title="Chromosome 11">11</a></li> <li><a href="/wiki/Chromosome_12" title="Chromosome 12">12</a></li> <li><a href="/wiki/Chromosome_13" title="Chromosome 13">13</a></li> <li><a href="/wiki/Chromosome_14" title="Chromosome 14">14</a></li> <li><a href="/wiki/Chromosome_15" title="Chromosome 15">15</a></li> <li><a href="/wiki/Chromosome_16" title="Chromosome 16">16</a></li> <li><a href="/wiki/Chromosome_17" title="Chromosome 17">17</a></li> <li><a href="/wiki/Chromosome_18" title="Chromosome 18">18</a></li> <li><a href="/wiki/Chromosome_19" title="Chromosome 19">19</a></li> <li><a href="/wiki/Chromosome_20" title="Chromosome 20">20</a></li> <li><a href="/wiki/Chromosome_21" title="Chromosome 21">21</a></li> <li><a href="/wiki/Chromosome_22" title="Chromosome 22">22</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Allosome" class="mw-redirect" title="Allosome">Sex chromosome</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/X_chromosome" title="X chromosome">X</a></li> <li><a href="/wiki/Y_chromosome" title="Y chromosome">Y</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mitochondrial_DNA" title="Mitochondrial DNA">Mitochondrial genome</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Human_mitochondrial_genetics" title="Human mitochondrial genetics">Human mitochondrial DNA</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Related topics</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Human_genome" title="Human genome">Human genome</a> <ul><li><a href="/wiki/Human_Genome_Project" title="Human Genome Project">Human Genome Project</a></li></ul></li> <li><a href="/wiki/List_of_human_genes" class="mw-redirect" title="List of human genes">List of human genes</a></li> <li><a href="/wiki/Archaeogenetics#Human_archaeology" title="Archaeogenetics">Human archaeology</a></li></ul> </div></td></tr></tbody></table></div> <!-- NewPP limit report Parsed by 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