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class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Francisco Cavalcante</h3></div><div class="js-work-strip profile--work_container" data-work-id="57236916"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/57236916/Effects_of_1_8_cineole_on_electrophysiological_parameters_of_neurons_of_the_rat_superior_cervical_ganglion"><img alt="Research paper thumbnail of Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion" class="work-thumbnail" src="https://attachments.academia-assets.com/72233475/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/57236916/Effects_of_1_8_cineole_on_electrophysiological_parameters_of_neurons_of_the_rat_superior_cervical_ganglion">Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Pharmacology and Physiology</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">1 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">1 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk medicine. It has been shown to have various pharmacological effects, including blockade of the compound action potential (AP). In the present study, using intracellular recording techniques, we investigated the effects of 1,8-cineole on the electrophysiological parameters of neurons of the superior cervical ganglion (SCG) in rats.2 1,8-Cineole (0.1–6 mmol/L) showed reversible and concentration-dependent effects on various electrophysiological parameters. At 3 and 6 mmol/L, but not at 0.1 and 1 mmol/L, 1,8-cineole significantly diminished the input resistance (Ri) and altered the resting potential (Em) to more positive values. At 6 mmol/L, 1,8-cineole completely blocked all APs within 2.7 ± 0.6 min (n = 12). In neurons exposed to 3 and 1 mmol/L 1,8-cineole, the effects regarding excitability varied from complete AP blockade to minor inhibition of AP parameters. The depolarization of Em an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c7fe77d9b5b4da8a8d3ea6f70cf2f3ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72233475,"asset_id":57236916,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72233475/download_file?st=MTczMjc1NTgxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="57236916"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="57236916"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 57236916; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=57236916]").text(description); $(".js-view-count[data-work-id=57236916]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 57236916; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='57236916']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 57236916, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c7fe77d9b5b4da8a8d3ea6f70cf2f3ec" } } $('.js-work-strip[data-work-id=57236916]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":57236916,"title":"Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion","translated_title":"","metadata":{"abstract":"1 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk medicine. It has been shown to have various pharmacological effects, including blockade of the compound action potential (AP). In the present study, using intracellular recording techniques, we investigated the effects of 1,8-cineole on the electrophysiological parameters of neurons of the superior cervical ganglion (SCG) in rats.2 1,8-Cineole (0.1–6 mmol/L) showed reversible and concentration-dependent effects on various electrophysiological parameters. At 3 and 6 mmol/L, but not at 0.1 and 1 mmol/L, 1,8-cineole significantly diminished the input resistance (Ri) and altered the resting potential (Em) to more positive values. At 6 mmol/L, 1,8-cineole completely blocked all APs within 2.7 ± 0.6 min (n = 12). In neurons exposed to 3 and 1 mmol/L 1,8-cineole, the effects regarding excitability varied from complete AP blockade to minor inhibition of AP parameters. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699813"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699813/Consequences_of_immobilization_and_disuse_a_short_review"><img alt="Research paper thumbnail of Consequences of immobilization and disuse: a short review" class="work-thumbnail" src="https://attachments.academia-assets.com/52015332/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699813/Consequences_of_immobilization_and_disuse_a_short_review">Consequences of immobilization and disuse: a short review</a></div><div class="wp-workCard_item"><span>International Journal of Basic and Applied Sciences</span><span>, Sep 15, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c18ac0a47a4575e31811a8d33fa90673" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52015332,"asset_id":31699813,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52015332/download_file?st=MTczMjc1NTgxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699813"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699813"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699813; 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There are a number of deleterious effects, including systems and organs such as the respiratory, cardiac and skeletal muscle. The clinical and physiological principal aspects revised in this short review are: muscular atrophy, general metabolic alterations, increase of connective tissue, muscular power loss, oxidative stress, loss of weight and neural changes. We conclude that immobilization/disuse should be evaluated and questioned if we really have indicated before being prescribed, as this causes many physiological and clinical deleterious effects.","publication_date":{"day":15,"month":9,"year":2013,"errors":{}},"publication_name":"International Journal of Basic and Applied Sciences","grobid_abstract_attachment_id":52015332},"translated_abstract":null,"internal_url":"https://www.academia.edu/31699813/Consequences_of_immobilization_and_disuse_a_short_review","translated_internal_url":"","created_at":"2017-03-03T13:00:13.344-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":52015332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015332/thumbnails/1.jpg","file_name":"1104-4189-1-PB.pdf","download_url":"https://www.academia.edu/attachments/52015332/download_file?st=MTczMjc1NTgxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Consequences_of_immobilization_and_disus.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015332/1104-4189-1-PB-libre.pdf?1488575424=\u0026response-content-disposition=attachment%3B+filename%3DConsequences_of_immobilization_and_disus.pdf\u0026Expires=1732759412\u0026Signature=AOBZ~dNFb3TygRZZxmYK1BS0hM1CqxflDcQxKNXJnGjldpKUT8~MyqqvKYv0eCZp2Ld2OYpOJEgWrKxR3avFlnCi2XpLbHIWvEDQXEtjqDFVnpzEhifATsxyePsbj-zmDgqp94C-~Thj-B5AeXLKXzL4y0qb-eyUZZZsWDffdWyNn2HgdbykXhretcvFytwQvq-CSBeRy5yrY3AkzA7WjmZ9tqCzUMgTgjqe02QjAFv8StNd1feLYRAPSNa2gFpmoqBpSq2PMG-QfIlfcUnOcuSIaGo6HFviEA40r4yj3faOpDXkoDjLbgSF7BWSRm~EiAzjB2p7r8Y0VOoHyOYlrQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Consequences_of_immobilization_and_disuse_a_short_review","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[{"id":52015332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015332/thumbnails/1.jpg","file_name":"1104-4189-1-PB.pdf","download_url":"https://www.academia.edu/attachments/52015332/download_file?st=MTczMjc1NTgxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Consequences_of_immobilization_and_disus.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015332/1104-4189-1-PB-libre.pdf?1488575424=\u0026response-content-disposition=attachment%3B+filename%3DConsequences_of_immobilization_and_disus.pdf\u0026Expires=1732759412\u0026Signature=AOBZ~dNFb3TygRZZxmYK1BS0hM1CqxflDcQxKNXJnGjldpKUT8~MyqqvKYv0eCZp2Ld2OYpOJEgWrKxR3avFlnCi2XpLbHIWvEDQXEtjqDFVnpzEhifATsxyePsbj-zmDgqp94C-~Thj-B5AeXLKXzL4y0qb-eyUZZZsWDffdWyNn2HgdbykXhretcvFytwQvq-CSBeRy5yrY3AkzA7WjmZ9tqCzUMgTgjqe02QjAFv8StNd1feLYRAPSNa2gFpmoqBpSq2PMG-QfIlfcUnOcuSIaGo6HFviEA40r4yj3faOpDXkoDjLbgSF7BWSRm~EiAzjB2p7r8Y0VOoHyOYlrQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":52015331,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015331/thumbnails/1.jpg","file_name":"1104-4189-1-PB.pdf","download_url":"https://www.academia.edu/attachments/52015331/download_file","bulk_download_file_name":"Consequences_of_immobilization_and_disus.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015331/1104-4189-1-PB-libre.pdf?1488575424=\u0026response-content-disposition=attachment%3B+filename%3DConsequences_of_immobilization_and_disus.pdf\u0026Expires=1732759412\u0026Signature=emvgShiG7Ygtr4~YRXE07rNpqHieHYPuq0G7JOthDNMHcwzjLc3G6Mi3Lhhx5U1mpbQ3hg2yuT~SxdgKZ8PcS4-6vq7a2DgOcTYEEK4eVCpCgY03ezsH8Q--ECF2Nmp4~eZQl~e6izMPnP4VtPz7BHP492iqOyAFx~4vwCCizol8BQ3tuofQDabMYfTP1zDCCAxvOjO3Wb9VcwPnZBVXraUunB82rCYWldKKP7kjMIlXDW~xHH66fgbow0qKOY9ARkl2bd0lCp-JEBAJ43~5pExLMkVtohJjyA71slNRBmDzY3WOg3mDpaONgUb68aUYhMbEOjE-qjAoOH2mg~cg2A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":7986304,"url":"http://www.sciencepubco.com/index.php/ijbas/article/download/1104/842"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699812"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699812/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities"><img alt="Research paper thumbnail of Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699812/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities">Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span><span>, Aug 1, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is primarily determined by lung connective tissue, and its elevated estimates from impedance data in the CC and OC conditions are a consequence of compartment-like heterogeneity being greater in CC and OC conditions than in the IL.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699812"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699812"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699812; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699812]").text(description); $(".js-view-count[data-work-id=31699812]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699812; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699812']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699812, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699812]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699812,"title":"Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities","translated_title":"","metadata":{"abstract":"We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is primarily determined by lung connective tissue, and its elevated estimates from impedance data in the CC and OC conditions are a consequence of compartment-like heterogeneity being greater in CC and OC conditions than in the IL.","publication_date":{"day":1,"month":8,"year":2001,"errors":{}},"publication_name":"Journal of Applied Physiology"},"translated_abstract":"We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is primarily determined by lung connective tissue, and its elevated estimates from impedance data in the CC and OC conditions are a consequence of compartment-like heterogeneity being greater in CC and OC conditions than in the IL.","internal_url":"https://www.academia.edu/31699812/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_internal_url":"","created_at":"2017-03-03T13:00:13.098-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":300,"name":"Mathematics","url":"https://www.academia.edu/Documents/in/Mathematics"},{"id":42496,"name":"Heterogeneity","url":"https://www.academia.edu/Documents/in/Heterogeneity"},{"id":43005,"name":"Hysteresis","url":"https://www.academia.edu/Documents/in/Hysteresis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":48904,"name":"Elasticity","url":"https://www.academia.edu/Documents/in/Elasticity"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":162147,"name":"Applied Physiology","url":"https://www.academia.edu/Documents/in/Applied_Physiology"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":250448,"name":"Impedance","url":"https://www.academia.edu/Documents/in/Impedance"},{"id":291038,"name":"Pressure","url":"https://www.academia.edu/Documents/in/Pressure"},{"id":350931,"name":"Mechanical Stress","url":"https://www.academia.edu/Documents/in/Mechanical_Stress"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":417494,"name":"Rat","url":"https://www.academia.edu/Documents/in/Rat"}],"urls":[{"id":7986303,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=14073081"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699811"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699811/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips"><img alt="Research paper thumbnail of Effects of collagenase and elastase on the mechanical properties of lung tissue strips" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699811/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips">Effects of collagenase and elastase on the mechanical properties of lung tissue strips</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span><span>, Jul 1, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspond...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). The costs of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699811"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699811"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699811; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699811]").text(description); $(".js-view-count[data-work-id=31699811]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699811; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699811']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699811, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699811]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699811,"title":"Effects of collagenase and elastase on the mechanical properties of lung tissue strips","translated_title":"","metadata":{"abstract":"... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). The costs of ...","publication_date":{"day":1,"month":7,"year":2000,"errors":{}},"publication_name":"Journal of Applied Physiology"},"translated_abstract":"... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). The costs of ...","internal_url":"https://www.academia.edu/31699811/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips","translated_internal_url":"","created_at":"2017-03-03T13:00:12.844-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":162147,"name":"Applied Physiology","url":"https://www.academia.edu/Documents/in/Applied_Physiology"}],"urls":[{"id":7986302,"url":"http://jap.physiology.org/content/89/1/3"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699810"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699810/Efeitos_clim%C3%A1ticos_do_metano_na_atmosfera"><img alt="Research paper thumbnail of Efeitos climáticos do metano na atmosfera" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699810/Efeitos_clim%C3%A1ticos_do_metano_na_atmosfera">Efeitos climáticos do metano na atmosfera</a></div><div class="wp-workCard_item"><span>Revista Tecnologia</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... (1) O metano foi descoberto por Alessandro Volta, que lhe deu o nome de gás dos pântanos. ......</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... (1) O metano foi descoberto por Alessandro Volta, que lhe deu o nome de gás dos pântanos. ... 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699808"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699808/USE_OF_POROUS_CATALYST_MATRIX_BASED_ON_METAL_ZEOLITE_Al_2_O_3_TO_LPG_COMBUSTION_POROUS_CATALYST_MATRIX_PREPARATION_AND_CHARACTERIZATION"><img alt="Research paper thumbnail of USE OF POROUS CATALYST MATRIX BASED ON METAL–ZEOLITE/Al 2 O 3 TO LPG COMBUSTION POROUS CATALYST MATRIX: PREPARATION AND CHARACTERIZATION" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699808/USE_OF_POROUS_CATALYST_MATRIX_BASED_ON_METAL_ZEOLITE_Al_2_O_3_TO_LPG_COMBUSTION_POROUS_CATALYST_MATRIX_PREPARATION_AND_CHARACTERIZATION">USE OF POROUS CATALYST MATRIX BASED ON METAL–ZEOLITE/Al 2 O 3 TO LPG COMBUSTION POROUS CATALYST MATRIX: PREPARATION AND CHARACTERIZATION</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The porous combustion radiant burners are a very important route for thermal power production pro...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The porous combustion radiant burners are a very important route for thermal power production processes in the engineering industry and can be used in a wide variety of industrial applications. This system is an alternative to obtain high potential heat energy, with significant reductions in emissions of typical pollutants from the combustion process. The heat recirculation extends the standard flammability limits and allows the burning of ultra-lean fuel mixtures, conserving energy resources, or the burning of gases of low calorific value, utilizing otherwise wasted resources. Thus, catalyst matrix was used in this work with metal-zeolite catalysts impregnated in alumina spheres, in specific Cu-ZSM-5/Al 2 O 3 and Fe-ZSM-5/Al 2 O 3. The performance of the burner was studied at different equivalence ratios and porous catalyst matrix, with a constant porosity for each two zones of burner to LPG combustion. The FeZSM5/Al 2 O 3 is the best porous catalyst matrix for this work. 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The Fe-ca..."},"translated_abstract":"The porous combustion radiant burners are a very important route for thermal power production processes in the engineering industry and can be used in a wide variety of industrial applications. This system is an alternative to obtain high potential heat energy, with significant reductions in emissions of typical pollutants from the combustion process. The heat recirculation extends the standard flammability limits and allows the burning of ultra-lean fuel mixtures, conserving energy resources, or the burning of gases of low calorific value, utilizing otherwise wasted resources. Thus, catalyst matrix was used in this work with metal-zeolite catalysts impregnated in alumina spheres, in specific Cu-ZSM-5/Al 2 O 3 and Fe-ZSM-5/Al 2 O 3. The performance of the burner was studied at different equivalence ratios and porous catalyst matrix, with a constant porosity for each two zones of burner to LPG combustion. The FeZSM5/Al 2 O 3 is the best porous catalyst matrix for this work. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699798"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699798/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities"><img alt="Research paper thumbnail of Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699798/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities">Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities</a></div><div class="wp-workCard_item"><span>Journal of applied physiology (Bethesda, Md. : 1985)</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is prim...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699798"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699798"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699798; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699798]").text(description); $(".js-view-count[data-work-id=31699798]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699798; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699798']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699798, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699798]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699798,"title":"Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities","translated_title":"","metadata":{"abstract":"We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is prim...","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Journal of applied physiology (Bethesda, Md. : 1985)"},"translated_abstract":"We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is prim...","internal_url":"https://www.academia.edu/31699798/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_internal_url":"","created_at":"2017-03-03T13:00:11.077-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":300,"name":"Mathematics","url":"https://www.academia.edu/Documents/in/Mathematics"},{"id":42496,"name":"Heterogeneity","url":"https://www.academia.edu/Documents/in/Heterogeneity"},{"id":43005,"name":"Hysteresis","url":"https://www.academia.edu/Documents/in/Hysteresis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":48904,"name":"Elasticity","url":"https://www.academia.edu/Documents/in/Elasticity"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":162147,"name":"Applied Physiology","url":"https://www.academia.edu/Documents/in/Applied_Physiology"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":250448,"name":"Impedance","url":"https://www.academia.edu/Documents/in/Impedance"},{"id":291038,"name":"Pressure","url":"https://www.academia.edu/Documents/in/Pressure"},{"id":350931,"name":"Mechanical Stress","url":"https://www.academia.edu/Documents/in/Mechanical_Stress"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":417494,"name":"Rat","url":"https://www.academia.edu/Documents/in/Rat"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699795"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699795/Fluid_flow_through_ramified_structures"><img alt="Research paper thumbnail of Fluid flow through ramified structures" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699795/Fluid_flow_through_ramified_structures">Fluid flow through ramified structures</a></div><div class="wp-workCard_item"><span>Physical Review E</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We investigate the fluid flow through two-dimensional ramified structures by direct simulation of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We investigate the fluid flow through two-dimensional ramified structures by direct simulation of the Navier-Stokes equations. We show that for trees with n generations, the flow distribution strongly depends on the Reynolds number Re. Specifically, for a tree without loops the flow becomes highly heterogeneous at high Re. For a tree with loops, on the other hand, the flow distribution tends to be more uniform at increased Re conditions. We show that these apparently contradictory behaviors have the same origin, namely, the effect of inertia on the momentum transport in the channels of the ramified geometry. In order to simulate the propagation of the flow imbalance throughout the tree without loops, we develop a simple model that incorporates the basic fluid dynamics features of the system. For large trees, the results of the model indicate that the distribution of flow at the outlet branches can be described by a self-affine landscape. Finally, we argue that the nonuniform partitioning of flow found for the structure without loops may contribute to the morphogenesis and functioning of the bronchial tree.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699795"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699795"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699795; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699795]").text(description); $(".js-view-count[data-work-id=31699795]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699795; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699795']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699795, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699795]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699795,"title":"Fluid flow through ramified structures","translated_title":"","metadata":{"abstract":"We investigate the fluid flow through two-dimensional ramified structures by direct simulation of the Navier-Stokes equations. We show that for trees with n generations, the flow distribution strongly depends on the Reynolds number Re. Specifically, for a tree without loops the flow becomes highly heterogeneous at high Re. For a tree with loops, on the other hand, the flow distribution tends to be more uniform at increased Re conditions. We show that these apparently contradictory behaviors have the same origin, namely, the effect of inertia on the momentum transport in the channels of the ramified geometry. In order to simulate the propagation of the flow imbalance throughout the tree without loops, we develop a simple model that incorporates the basic fluid dynamics features of the system. For large trees, the results of the model indicate that the distribution of flow at the outlet branches can be described by a self-affine landscape. Finally, we argue that the nonuniform partitioning of flow found for the structure without loops may contribute to the morphogenesis and functioning of the bronchial tree.","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Physical Review E"},"translated_abstract":"We investigate the fluid flow through two-dimensional ramified structures by direct simulation of the Navier-Stokes equations. We show that for trees with n generations, the flow distribution strongly depends on the Reynolds number Re. Specifically, for a tree without loops the flow becomes highly heterogeneous at high Re. For a tree with loops, on the other hand, the flow distribution tends to be more uniform at increased Re conditions. We show that these apparently contradictory behaviors have the same origin, namely, the effect of inertia on the momentum transport in the channels of the ramified geometry. In order to simulate the propagation of the flow imbalance throughout the tree without loops, we develop a simple model that incorporates the basic fluid dynamics features of the system. For large trees, the results of the model indicate that the distribution of flow at the outlet branches can be described by a self-affine landscape. Finally, we argue that the nonuniform partitioning of flow found for the structure without loops may contribute to the morphogenesis and functioning of the bronchial tree.","internal_url":"https://www.academia.edu/31699795/Fluid_flow_through_ramified_structures","translated_internal_url":"","created_at":"2017-03-03T13:00:10.868-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Fluid_flow_through_ramified_structures","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":8067,"name":"Heat Transfer","url":"https://www.academia.edu/Documents/in/Heat_Transfer"},{"id":16496,"name":"Fluid Dynamics","url":"https://www.academia.edu/Documents/in/Fluid_Dynamics"},{"id":215076,"name":"Fluid flow","url":"https://www.academia.edu/Documents/in/Fluid_flow"},{"id":1008960,"name":"Reynolds Number","url":"https://www.academia.edu/Documents/in/Reynolds_Number"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699791"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699791/Self_organized_percolation_growth_in_regular_and_disordered_lattices"><img alt="Research paper thumbnail of Self-organized percolation growth in regular and disordered lattices" class="work-thumbnail" src="https://attachments.academia-assets.com/52015343/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699791/Self_organized_percolation_growth_in_regular_and_disordered_lattices">Self-organized percolation growth in regular and disordered lattices</a></div><div class="wp-workCard_item"><span>Physica A: Statistical Mechanics and its Applications</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7304c151f822cbeb9f0da06a85f28a85" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52015343,"asset_id":31699791,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52015343/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699791"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699791"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699791; 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By controlling the number of sites or bonds in the growth front of the aggregate, the system is spontaneously driven to a stationary state that corresponds to approximately the percolation threshold of the lattice topology and percolation process. The SOP model is applied here to site and bond percolation in several regular lattices in two and three dimensions (triangular, honeycomb and simple cubic), as well as in a disordered network (Voronoi-Delaunai). Based on these results, we propose the use of this growth algorithm as a plausible model to describe the dynamics and the anomalous geometrical properties of some natural processes.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Physica A: Statistical Mechanics and its Applications","grobid_abstract_attachment_id":52015343},"translated_abstract":null,"internal_url":"https://www.academia.edu/31699791/Self_organized_percolation_growth_in_regular_and_disordered_lattices","translated_internal_url":"","created_at":"2017-03-03T13:00:10.492-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":52015343,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015343/thumbnails/1.jpg","file_name":"s0378-4371_2802_2900833-620170303-30380-1yr8pil.pdf","download_url":"https://www.academia.edu/attachments/52015343/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Self_organized_percolation_growth_in_reg.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015343/s0378-4371_2802_2900833-620170303-30380-1yr8pil-libre.pdf?1488575423=\u0026response-content-disposition=attachment%3B+filename%3DSelf_organized_percolation_growth_in_reg.pdf\u0026Expires=1732759413\u0026Signature=agixlSIwCX8t0KNJyuV05eWWfE981VG0yOMibVxVRziwS85pa4MmYSnYRhrU~laNjMz5PY2waT807c-QoKs8dQGIuWx77AZcXu0t01ig~bQ8vZcnz34Y~zAICzd5z0DvbIVahvqRPnEmBvwZlIM9GGNUfdYsb8g5DO6T9SgoH~4nf2SfaH3zMq8tuBCZ5XM-ru9DtjDp14tTdzngSHrGezWJNriQL043sYO0-iNvpeQ7mgJ50tmazjkCbpylnT~C9WZv50ktD03~TUdvDrwrglF8FFHBOmADnejwhWE42bl1-i0P4SHUM9cX-UC9pGuGquREf3iFW4tUnzoYDCKzTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Self_organized_percolation_growth_in_regular_and_disordered_lattices","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[{"id":52015343,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015343/thumbnails/1.jpg","file_name":"s0378-4371_2802_2900833-620170303-30380-1yr8pil.pdf","download_url":"https://www.academia.edu/attachments/52015343/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Self_organized_percolation_growth_in_reg.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015343/s0378-4371_2802_2900833-620170303-30380-1yr8pil-libre.pdf?1488575423=\u0026response-content-disposition=attachment%3B+filename%3DSelf_organized_percolation_growth_in_reg.pdf\u0026Expires=1732759413\u0026Signature=agixlSIwCX8t0KNJyuV05eWWfE981VG0yOMibVxVRziwS85pa4MmYSnYRhrU~laNjMz5PY2waT807c-QoKs8dQGIuWx77AZcXu0t01ig~bQ8vZcnz34Y~zAICzd5z0DvbIVahvqRPnEmBvwZlIM9GGNUfdYsb8g5DO6T9SgoH~4nf2SfaH3zMq8tuBCZ5XM-ru9DtjDp14tTdzngSHrGezWJNriQL043sYO0-iNvpeQ7mgJ50tmazjkCbpylnT~C9WZv50ktD03~TUdvDrwrglF8FFHBOmADnejwhWE42bl1-i0P4SHUM9cX-UC9pGuGquREf3iFW4tUnzoYDCKzTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":318,"name":"Mathematical Physics","url":"https://www.academia.edu/Documents/in/Mathematical_Physics"},{"id":518,"name":"Quantum Physics","url":"https://www.academia.edu/Documents/in/Quantum_Physics"},{"id":50071,"name":"Percolation","url":"https://www.academia.edu/Documents/in/Percolation"},{"id":54961,"name":"Growth","url":"https://www.academia.edu/Documents/in/Growth"},{"id":299563,"name":"Self Organization","url":"https://www.academia.edu/Documents/in/Self_Organization"},{"id":385916,"name":"Percolation threshold","url":"https://www.academia.edu/Documents/in/Percolation_threshold"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699790"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699790/Essential_Oil_of_Croton_Nepetaefolius_and_Its_Main_Constituent_1_8_CINEOLE_Block_Excitability_of_Rat_Sciatic_Nerve_in_Vitro"><img alt="Research paper thumbnail of Essential Oil of Croton Nepetaefolius and Its Main Constituent, 1,8-CINEOLE, Block Excitability of Rat Sciatic Nerve in Vitro" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699790/Essential_Oil_of_Croton_Nepetaefolius_and_Its_Main_Constituent_1_8_CINEOLE_Block_Excitability_of_Rat_Sciatic_Nerve_in_Vitro">Essential Oil of Croton Nepetaefolius and Its Main Constituent, 1,8-CINEOLE, Block Excitability of Rat Sciatic Nerve in Vitro</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Pharmacology and Physiology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8-cineole, on the compound action potential (CAP) of nerve were investigated. 2. Experiments were performed in sciatic nerves dissected from Wistar rats, mounted in a moist chamber and stimulated at a frequency of 0.2 Hz, with electric pulses of 100 micros duration at 20-40 V. Evoked CAP were displayed on an oscilloscope and recorded on a computer. The CAP control parameters were as follows: peak-to-peak amplitude 8.1 +/- 0.6 mV (n = 15); conduction velocity 83.3 +/- 4.2 m/s (n = 15); chronaxie 58.0 +/- 6.8 msec (n = 6); and rheobase 2.8 +/- 0.1 V (n = 6). 3. Lower concentrations of EOCN (100 and 300 microg/mL) and 1,8-cineole (153 and 307 microg/mL; i.e. 1 and 2 mmol/L, respectively) had no significant effects on CAP control parameters throughout the entire recording period. However, at the end of 180 min exposure of the nerve to the drug, peak-to-peak amplitude was significantly (P &amp;lt; 0.05) reduced to 27.4 +/- 6.7 and 1.7 +/- 0.8% of control values by 500 and 1000 microg/mL EOCN, respectively (n = 6), and to 76.5 +/- 4.4, 70.0 +/- 3.9 and 14.8 +/- 4.1% of control values by 614, 920 and 1227 microg/mL (i.e. 4, 6 and 8 mmol/L) 1,8-cineole, respectively (n = 6). Regarding conduction velocity, at the end of the 180 min exposure period, this parameter was significantly reduced to 85.8 +/- 7.3 and 48.7 +/- 12.3% (n = 6) of control values by 500 and 1000 microg/mL EOCN, respectively, and to 86.4 +/- 4.5 and 76.1 +/- 5.2% (n = 6) by 920 and 1227 microg/mL 1,8-cineole, respectively. Chronaxie and rheobase were significantly increased by the higher concentrations of both EOCN and 1,8-cineole. 4. It is concluded that EOCN and its main constituent 1,8-cineole block nerve excitability in a concentration-dependent manner, an effect that was totally reversible with 1,8-cineole but not with EOCN. This suggests that other constituents of EOCN, in addition to 1,8-cineole, may contribute to the mediation of this effect of EOCN.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699790"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699790"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699790; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699790]").text(description); $(".js-view-count[data-work-id=31699790]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699790; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699790']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699790, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699790]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699790,"title":"Essential Oil of Croton Nepetaefolius and Its Main Constituent, 1,8-CINEOLE, Block Excitability of Rat Sciatic Nerve in Vitro","translated_title":"","metadata":{"abstract":"1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8-cineole, on the compound action potential (CAP) of nerve were investigated. 2. Experiments were performed in sciatic nerves dissected from Wistar rats, mounted in a moist chamber and stimulated at a frequency of 0.2 Hz, with electric pulses of 100 micros duration at 20-40 V. Evoked CAP were displayed on an oscilloscope and recorded on a computer. The CAP control parameters were as follows: peak-to-peak amplitude 8.1 +/- 0.6 mV (n = 15); conduction velocity 83.3 +/- 4.2 m/s (n = 15); chronaxie 58.0 +/- 6.8 msec (n = 6); and rheobase 2.8 +/- 0.1 V (n = 6). 3. Lower concentrations of EOCN (100 and 300 microg/mL) and 1,8-cineole (153 and 307 microg/mL; i.e. 1 and 2 mmol/L, respectively) had no significant effects on CAP control parameters throughout the entire recording period. However, at the end of 180 min exposure of the nerve to the drug, peak-to-peak amplitude was significantly (P \u0026amp;lt; 0.05) reduced to 27.4 +/- 6.7 and 1.7 +/- 0.8% of control values by 500 and 1000 microg/mL EOCN, respectively (n = 6), and to 76.5 +/- 4.4, 70.0 +/- 3.9 and 14.8 +/- 4.1% of control values by 614, 920 and 1227 microg/mL (i.e. 4, 6 and 8 mmol/L) 1,8-cineole, respectively (n = 6). Regarding conduction velocity, at the end of the 180 min exposure period, this parameter was significantly reduced to 85.8 +/- 7.3 and 48.7 +/- 12.3% (n = 6) of control values by 500 and 1000 microg/mL EOCN, respectively, and to 86.4 +/- 4.5 and 76.1 +/- 5.2% (n = 6) by 920 and 1227 microg/mL 1,8-cineole, respectively. Chronaxie and rheobase were significantly increased by the higher concentrations of both EOCN and 1,8-cineole. 4. It is concluded that EOCN and its main constituent 1,8-cineole block nerve excitability in a concentration-dependent manner, an effect that was totally reversible with 1,8-cineole but not with EOCN. This suggests that other constituents of EOCN, in addition to 1,8-cineole, may contribute to the mediation of this effect of EOCN.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Clinical and Experimental Pharmacology and Physiology"},"translated_abstract":"1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8-cineole, on the compound action potential (CAP) of nerve were investigated. 2. Experiments were performed in sciatic nerves dissected from Wistar rats, mounted in a moist chamber and stimulated at a frequency of 0.2 Hz, with electric pulses of 100 micros duration at 20-40 V. Evoked CAP were displayed on an oscilloscope and recorded on a computer. The CAP control parameters were as follows: peak-to-peak amplitude 8.1 +/- 0.6 mV (n = 15); conduction velocity 83.3 +/- 4.2 m/s (n = 15); chronaxie 58.0 +/- 6.8 msec (n = 6); and rheobase 2.8 +/- 0.1 V (n = 6). 3. Lower concentrations of EOCN (100 and 300 microg/mL) and 1,8-cineole (153 and 307 microg/mL; i.e. 1 and 2 mmol/L, respectively) had no significant effects on CAP control parameters throughout the entire recording period. However, at the end of 180 min exposure of the nerve to the drug, peak-to-peak amplitude was significantly (P \u0026amp;lt; 0.05) reduced to 27.4 +/- 6.7 and 1.7 +/- 0.8% of control values by 500 and 1000 microg/mL EOCN, respectively (n = 6), and to 76.5 +/- 4.4, 70.0 +/- 3.9 and 14.8 +/- 4.1% of control values by 614, 920 and 1227 microg/mL (i.e. 4, 6 and 8 mmol/L) 1,8-cineole, respectively (n = 6). Regarding conduction velocity, at the end of the 180 min exposure period, this parameter was significantly reduced to 85.8 +/- 7.3 and 48.7 +/- 12.3% (n = 6) of control values by 500 and 1000 microg/mL EOCN, respectively, and to 86.4 +/- 4.5 and 76.1 +/- 5.2% (n = 6) by 920 and 1227 microg/mL 1,8-cineole, respectively. Chronaxie and rheobase were significantly increased by the higher concentrations of both EOCN and 1,8-cineole. 4. It is concluded that EOCN and its main constituent 1,8-cineole block nerve excitability in a concentration-dependent manner, an effect that was totally reversible with 1,8-cineole but not with EOCN. 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Suki et al. (35 ... Footnotes. Address for reprint requests and other correspond...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). The costs of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699789"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699789"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699789; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699789]").text(description); $(".js-view-count[data-work-id=31699789]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699789; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699789']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699789, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699789]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699789,"title":"Effects of collagenase and elastase on the mechanical properties of lung tissue strips","translated_title":"","metadata":{"abstract":"... in parallel. 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The costs of ...","internal_url":"https://www.academia.edu/31699789/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips","translated_internal_url":"","created_at":"2017-03-03T13:00:10.169-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":162147,"name":"Applied Physiology","url":"https://www.academia.edu/Documents/in/Applied_Physiology"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31680283"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31680283/Form_of_the_quantum_kinetic_energy_operator_with_spatially_varying_effective_mass"><img alt="Research paper thumbnail of Form of the quantum kinetic-energy operator with spatially varying effective mass" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31680283/Form_of_the_quantum_kinetic_energy_operator_with_spatially_varying_effective_mass">Form of the quantum kinetic-energy operator with spatially varying effective mass</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante">Francisco Cavalcante</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/RamosFerreira">Ramos Ferreira</a></span></div><div class="wp-workCard_item"><span>Physical Review B</span><span>, 1997</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... FSA Cavalcante,* RN Costa Filho, J. Ribeiro Filho, CAS de Almeida, and VN Freire Departamento...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... FSA Cavalcante,* RN Costa Filho, J. Ribeiro Filho, CAS de Almeida, and VN Freire Departamento de Fısica, Universidade Federal do Ceará, Centro ... At this point, it is worth highlighting that the famous original publications of Schrödinger allow us to ponder the assumption of a ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31680283"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31680283"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31680283; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31680283]").text(description); $(".js-view-count[data-work-id=31680283]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31680283; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31680283']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31680283, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31680283]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31680283,"title":"Form of the quantum kinetic-energy operator with spatially varying effective mass","translated_title":"","metadata":{"abstract":"... 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31680282"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31680282/Mechanical_interactions_between_collagen_and_proteoglycans_implications_for_the_stability_of_lung_tissue"><img alt="Research paper thumbnail of Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue" class="work-thumbnail" src="https://attachments.academia-assets.com/52000116/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31680282/Mechanical_interactions_between_collagen_and_proteoglycans_implications_for_the_stability_of_lung_tissue">Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4b72c3bd93c3e3d783baadf108af0b21" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52000116,"asset_id":31680282,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52000116/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31680282"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31680282"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31680282; 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Collagen and elastin are thought to dominate the elasticity of the connective tissue including lung parenchyma. The glycosaminoglycans on the proteoglycans may also play a role because osmolarity of interstitial fluid can alter the repulsive forces on the negatively charged glycosaminoglycans, allowing them to collapse or inflate, which can affect the stretching and folding pattern of the fibers. Hence, we hypothesized that the elasticity of lung tissue arises primarily from 1) the topology of the collagen-elastin network and 2) the mechanical interaction between proteoglycans and fibers. We measured the quasi-static, uniaxial stress-strain curves of lung tissue sheets in hypotonic, normal, and hypertonic solutions. We found that the stress-strain curve was sensitive to osmolarity, but this sensitivity decreased after proteoglycan digestion. Images of immunofluorescently labeled collagen networks showed that the fibers follow the alveolar walls that form a hexagonal-like structure. Despite the large heterogeneity, the aspect ratio of the hexagons at 30% uniaxial strain increased linearly with osmolarity. We developed a two-dimensional hexagonal network model of the alveolar structure incorporating the mechanical properties of the collagen-elastin fibers and their interaction with proteoglycans. The model accounted for the stressstrain curves observed under all experimental conditions. The model also predicted how aspect ratio changed with osmolarity and strain, which allowed us to estimate the Young's modulus of a single alveolar wall and a collagen fiber. We therefore identify a novel and important role for the proteoglycans: they stabilize the collagenelastin network of connective tissues and contribute to lung elasticity and alveolar stability at low to medium lung volumes. . Collagen-labeled unstretched tissue at a higher magnification. Note that wavy collagen fibers are running nearly parallel in the alveolar walls. 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terpenoid oxide believed to have medicinal properties in folk medicine. It has been shown to have various pharmacological effects, including blockade of the compound action potential (AP). In the present study, using intracellular recording techniques, we investigated the effects of 1,8-cineole on the electrophysiological parameters of neurons of the superior cervical ganglion (SCG) in rats.","publication_date":{"day":null,"month":null,"year":2009,"errors":{}},"grobid_abstract_attachment_id":44771111},"translated_abstract":null,"internal_url":"https://www.academia.edu/13953914/Effects_of_1_8_cineole_on_electrophysiological_parameters_of_neurons_of_the_rat_superior_cervical_ganglion","translated_internal_url":"","created_at":"2015-07-12T11:23:52.508-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":33006783,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":2954470,"work_id":13953914,"tagging_user_id":33006783,"tagged_user_id":33068793,"co_author_invite_id":177733,"email":"m***o@ufc.br","display_order":0,"name":"Maria Oliveira","title":"Effects of 1, 8‐cineole on electrophysiological parameters of neurons 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id="papers"><div class="js-work-strip profile--work_container" data-work-id="57236916"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/57236916/Effects_of_1_8_cineole_on_electrophysiological_parameters_of_neurons_of_the_rat_superior_cervical_ganglion"><img alt="Research paper thumbnail of Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion" class="work-thumbnail" src="https://attachments.academia-assets.com/72233475/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/57236916/Effects_of_1_8_cineole_on_electrophysiological_parameters_of_neurons_of_the_rat_superior_cervical_ganglion">Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Pharmacology and Physiology</span><span>, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">1 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">1 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk medicine. It has been shown to have various pharmacological effects, including blockade of the compound action potential (AP). In the present study, using intracellular recording techniques, we investigated the effects of 1,8-cineole on the electrophysiological parameters of neurons of the superior cervical ganglion (SCG) in rats.2 1,8-Cineole (0.1–6 mmol/L) showed reversible and concentration-dependent effects on various electrophysiological parameters. At 3 and 6 mmol/L, but not at 0.1 and 1 mmol/L, 1,8-cineole significantly diminished the input resistance (Ri) and altered the resting potential (Em) to more positive values. At 6 mmol/L, 1,8-cineole completely blocked all APs within 2.7 ± 0.6 min (n = 12). In neurons exposed to 3 and 1 mmol/L 1,8-cineole, the effects regarding excitability varied from complete AP blockade to minor inhibition of AP parameters. The depolarization of Em an...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c7fe77d9b5b4da8a8d3ea6f70cf2f3ec" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":72233475,"asset_id":57236916,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/72233475/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NTgxMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="57236916"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="57236916"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 57236916; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=57236916]").text(description); $(".js-view-count[data-work-id=57236916]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 57236916; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='57236916']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 57236916, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c7fe77d9b5b4da8a8d3ea6f70cf2f3ec" } } $('.js-work-strip[data-work-id=57236916]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":57236916,"title":"Effects of 1,8-cineole on electrophysiological parameters of neurons of the rat superior cervical ganglion","translated_title":"","metadata":{"abstract":"1 1,8-Cineole is a non-toxic small terpenoid oxide believed to have medicinal properties in folk medicine. 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There are a number of deleterious effects, including systems and organs such as the respiratory, cardiac and skeletal muscle. The clinical and physiological principal aspects revised in this short review are: muscular atrophy, general metabolic alterations, increase of connective tissue, muscular power loss, oxidative stress, loss of weight and neural changes. We conclude that immobilization/disuse should be evaluated and questioned if we really have indicated before being prescribed, as this causes many physiological and clinical deleterious effects.","publication_date":{"day":15,"month":9,"year":2013,"errors":{}},"publication_name":"International Journal of Basic and Applied Sciences","grobid_abstract_attachment_id":52015332},"translated_abstract":null,"internal_url":"https://www.academia.edu/31699813/Consequences_of_immobilization_and_disuse_a_short_review","translated_internal_url":"","created_at":"2017-03-03T13:00:13.344-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":52015332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015332/thumbnails/1.jpg","file_name":"1104-4189-1-PB.pdf","download_url":"https://www.academia.edu/attachments/52015332/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NTgxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Consequences_of_immobilization_and_disus.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015332/1104-4189-1-PB-libre.pdf?1488575424=\u0026response-content-disposition=attachment%3B+filename%3DConsequences_of_immobilization_and_disus.pdf\u0026Expires=1732759412\u0026Signature=AOBZ~dNFb3TygRZZxmYK1BS0hM1CqxflDcQxKNXJnGjldpKUT8~MyqqvKYv0eCZp2Ld2OYpOJEgWrKxR3avFlnCi2XpLbHIWvEDQXEtjqDFVnpzEhifATsxyePsbj-zmDgqp94C-~Thj-B5AeXLKXzL4y0qb-eyUZZZsWDffdWyNn2HgdbykXhretcvFytwQvq-CSBeRy5yrY3AkzA7WjmZ9tqCzUMgTgjqe02QjAFv8StNd1feLYRAPSNa2gFpmoqBpSq2PMG-QfIlfcUnOcuSIaGo6HFviEA40r4yj3faOpDXkoDjLbgSF7BWSRm~EiAzjB2p7r8Y0VOoHyOYlrQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Consequences_of_immobilization_and_disuse_a_short_review","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[{"id":52015332,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015332/thumbnails/1.jpg","file_name":"1104-4189-1-PB.pdf","download_url":"https://www.academia.edu/attachments/52015332/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NTgxMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Consequences_of_immobilization_and_disus.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015332/1104-4189-1-PB-libre.pdf?1488575424=\u0026response-content-disposition=attachment%3B+filename%3DConsequences_of_immobilization_and_disus.pdf\u0026Expires=1732759412\u0026Signature=AOBZ~dNFb3TygRZZxmYK1BS0hM1CqxflDcQxKNXJnGjldpKUT8~MyqqvKYv0eCZp2Ld2OYpOJEgWrKxR3avFlnCi2XpLbHIWvEDQXEtjqDFVnpzEhifATsxyePsbj-zmDgqp94C-~Thj-B5AeXLKXzL4y0qb-eyUZZZsWDffdWyNn2HgdbykXhretcvFytwQvq-CSBeRy5yrY3AkzA7WjmZ9tqCzUMgTgjqe02QjAFv8StNd1feLYRAPSNa2gFpmoqBpSq2PMG-QfIlfcUnOcuSIaGo6HFviEA40r4yj3faOpDXkoDjLbgSF7BWSRm~EiAzjB2p7r8Y0VOoHyOYlrQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":52015331,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015331/thumbnails/1.jpg","file_name":"1104-4189-1-PB.pdf","download_url":"https://www.academia.edu/attachments/52015331/download_file","bulk_download_file_name":"Consequences_of_immobilization_and_disus.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015331/1104-4189-1-PB-libre.pdf?1488575424=\u0026response-content-disposition=attachment%3B+filename%3DConsequences_of_immobilization_and_disus.pdf\u0026Expires=1732759412\u0026Signature=emvgShiG7Ygtr4~YRXE07rNpqHieHYPuq0G7JOthDNMHcwzjLc3G6Mi3Lhhx5U1mpbQ3hg2yuT~SxdgKZ8PcS4-6vq7a2DgOcTYEEK4eVCpCgY03ezsH8Q--ECF2Nmp4~eZQl~e6izMPnP4VtPz7BHP492iqOyAFx~4vwCCizol8BQ3tuofQDabMYfTP1zDCCAxvOjO3Wb9VcwPnZBVXraUunB82rCYWldKKP7kjMIlXDW~xHH66fgbow0qKOY9ARkl2bd0lCp-JEBAJ43~5pExLMkVtohJjyA71slNRBmDzY3WOg3mDpaONgUb68aUYhMbEOjE-qjAoOH2mg~cg2A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":7986304,"url":"http://www.sciencepubco.com/index.php/ijbas/article/download/1104/842"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699812"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699812/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities"><img alt="Research paper thumbnail of Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699812/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities">Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span><span>, Aug 1, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is primarily determined by lung connective tissue, and its elevated estimates from impedance data in the CC and OC conditions are a consequence of compartment-like heterogeneity being greater in CC and OC conditions than in the IL.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699812"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699812"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699812; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699812]").text(description); $(".js-view-count[data-work-id=31699812]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699812; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699812']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699812, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699812]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699812,"title":"Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities","translated_title":"","metadata":{"abstract":"We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is primarily determined by lung connective tissue, and its elevated estimates from impedance data in the CC and OC conditions are a consequence of compartment-like heterogeneity being greater in CC and OC conditions than in the IL.","publication_date":{"day":1,"month":8,"year":2001,"errors":{}},"publication_name":"Journal of Applied Physiology"},"translated_abstract":"We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is primarily determined by lung connective tissue, and its elevated estimates from impedance data in the CC and OC conditions are a consequence of compartment-like heterogeneity being greater in CC and OC conditions than in the IL.","internal_url":"https://www.academia.edu/31699812/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_internal_url":"","created_at":"2017-03-03T13:00:13.098-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":300,"name":"Mathematics","url":"https://www.academia.edu/Documents/in/Mathematics"},{"id":42496,"name":"Heterogeneity","url":"https://www.academia.edu/Documents/in/Heterogeneity"},{"id":43005,"name":"Hysteresis","url":"https://www.academia.edu/Documents/in/Hysteresis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":48904,"name":"Elasticity","url":"https://www.academia.edu/Documents/in/Elasticity"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":162147,"name":"Applied Physiology","url":"https://www.academia.edu/Documents/in/Applied_Physiology"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":250448,"name":"Impedance","url":"https://www.academia.edu/Documents/in/Impedance"},{"id":291038,"name":"Pressure","url":"https://www.academia.edu/Documents/in/Pressure"},{"id":350931,"name":"Mechanical Stress","url":"https://www.academia.edu/Documents/in/Mechanical_Stress"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":417494,"name":"Rat","url":"https://www.academia.edu/Documents/in/Rat"}],"urls":[{"id":7986303,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=14073081"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699811"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699811/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips"><img alt="Research paper thumbnail of Effects of collagenase and elastase on the mechanical properties of lung tissue strips" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699811/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips">Effects of collagenase and elastase on the mechanical properties of lung tissue strips</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span><span>, Jul 1, 2000</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspond...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). The costs of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699811"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699811"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699811; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699811]").text(description); $(".js-view-count[data-work-id=31699811]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699811; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699811']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699811, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699811]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699811,"title":"Effects of collagenase and elastase on the mechanical properties of lung tissue strips","translated_title":"","metadata":{"abstract":"... in parallel. 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The costs of ...","internal_url":"https://www.academia.edu/31699811/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips","translated_internal_url":"","created_at":"2017-03-03T13:00:12.844-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":162147,"name":"Applied Physiology","url":"https://www.academia.edu/Documents/in/Applied_Physiology"}],"urls":[{"id":7986302,"url":"http://jap.physiology.org/content/89/1/3"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699810"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699810/Efeitos_clim%C3%A1ticos_do_metano_na_atmosfera"><img alt="Research paper thumbnail of Efeitos climáticos do metano na atmosfera" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699810/Efeitos_clim%C3%A1ticos_do_metano_na_atmosfera">Efeitos climáticos do metano na atmosfera</a></div><div class="wp-workCard_item"><span>Revista Tecnologia</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... (1) O metano foi descoberto por Alessandro Volta, que lhe deu o nome de gás dos pântanos. ......</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... (1) O metano foi descoberto por Alessandro Volta, que lhe deu o nome de gás dos pântanos. ... Por ser uma substância apolar, o metano quando liquefeito é pouco solúvel em água, mas muito solúvel em líquidos orgânicos como a gasolina, o éter ou o álcool, sendo essas ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699810"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699810"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699810; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699810]").text(description); $(".js-view-count[data-work-id=31699810]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699810; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699810']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699810, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699810]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699810,"title":"Efeitos climáticos do metano na atmosfera","translated_title":"","metadata":{"abstract":"... (1) O metano foi descoberto por Alessandro Volta, que lhe deu o nome de gás dos pântanos. ... Por ser uma substância apolar, o metano quando liquefeito é pouco solúvel em água, mas muito solúvel em líquidos orgânicos como a gasolina, o éter ou o álcool, sendo essas ...","publication_date":{"day":null,"month":null,"year":2008,"errors":{}},"publication_name":"Revista Tecnologia"},"translated_abstract":"... (1) O metano foi descoberto por Alessandro Volta, que lhe deu o nome de gás dos pântanos. ... 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This system is an alternative to obtain high potential heat energy, with significant reductions in emissions of typical pollutants from the combustion process. The heat recirculation extends the standard flammability limits and allows the burning of ultra-lean fuel mixtures, conserving energy resources, or the burning of gases of low calorific value, utilizing otherwise wasted resources. Thus, catalyst matrix was used in this work with metal-zeolite catalysts impregnated in alumina spheres, in specific Cu-ZSM-5/Al 2 O 3 and Fe-ZSM-5/Al 2 O 3. The performance of the burner was studied at different equivalence ratios and porous catalyst matrix, with a constant porosity for each two zones of burner to LPG combustion. The FeZSM5/Al 2 O 3 is the best porous catalyst matrix for this work. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699798"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699798/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities"><img alt="Research paper thumbnail of Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699798/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities">Hysteresivity of the lung and tissue strip in the normal rat: effects of heterogeneities</a></div><div class="wp-workCard_item"><span>Journal of applied physiology (Bethesda, Md. : 1985)</span><span>, 2001</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL)...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. 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We conclude that eta is prim...","publication_date":{"day":null,"month":null,"year":2001,"errors":{}},"publication_name":"Journal of applied physiology (Bethesda, Md. : 1985)"},"translated_abstract":"We measured lung impedance in rats in closed chest (CC), open chest (OC), and isolated lungs (IL) at four transpulmonary pressures with a optimal ventilator waveform. Data were analyzed with an homogeneous linear or an inhomogeneous linear model. Both models include tissue damping and elastance and airway inertance. The homogeneous linear model includes airway resistance (Raw), whereas the inhomogeneous linear model has a continuous distribution of Raw characterized by the mean Raw and the standard deviation of Raw (SDR). Lung mechanics were compared with tissue strip mechanics at frequencies and operating stresses comparable to those during lung impedance measurements. The hysteresivity (eta) was calculated as tissue damping/elastance. We found that 1) airway and tissue parameters were different in the IL than in the CC and OC conditions; 2) SDR was lowest in the IL; and 3) eta in IL at low transpulmonary pressure was similar to eta in the tissue strip. We conclude that eta is prim...","internal_url":"https://www.academia.edu/31699798/Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_internal_url":"","created_at":"2017-03-03T13:00:11.077-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Hysteresivity_of_the_lung_and_tissue_strip_in_the_normal_rat_effects_of_heterogeneities","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":300,"name":"Mathematics","url":"https://www.academia.edu/Documents/in/Mathematics"},{"id":42496,"name":"Heterogeneity","url":"https://www.academia.edu/Documents/in/Heterogeneity"},{"id":43005,"name":"Hysteresis","url":"https://www.academia.edu/Documents/in/Hysteresis"},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":48904,"name":"Elasticity","url":"https://www.academia.edu/Documents/in/Elasticity"},{"id":96098,"name":"Resistance","url":"https://www.academia.edu/Documents/in/Resistance"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":162147,"name":"Applied Physiology","url":"https://www.academia.edu/Documents/in/Applied_Physiology"},{"id":197297,"name":"Lung","url":"https://www.academia.edu/Documents/in/Lung"},{"id":250448,"name":"Impedance","url":"https://www.academia.edu/Documents/in/Impedance"},{"id":291038,"name":"Pressure","url":"https://www.academia.edu/Documents/in/Pressure"},{"id":350931,"name":"Mechanical Stress","url":"https://www.academia.edu/Documents/in/Mechanical_Stress"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":417494,"name":"Rat","url":"https://www.academia.edu/Documents/in/Rat"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699795"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699795/Fluid_flow_through_ramified_structures"><img alt="Research paper thumbnail of Fluid flow through ramified structures" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699795/Fluid_flow_through_ramified_structures">Fluid flow through ramified structures</a></div><div class="wp-workCard_item"><span>Physical Review E</span><span>, 1999</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">We investigate the fluid flow through two-dimensional ramified structures by direct simulation of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">We investigate the fluid flow through two-dimensional ramified structures by direct simulation of the Navier-Stokes equations. We show that for trees with n generations, the flow distribution strongly depends on the Reynolds number Re. Specifically, for a tree without loops the flow becomes highly heterogeneous at high Re. For a tree with loops, on the other hand, the flow distribution tends to be more uniform at increased Re conditions. We show that these apparently contradictory behaviors have the same origin, namely, the effect of inertia on the momentum transport in the channels of the ramified geometry. In order to simulate the propagation of the flow imbalance throughout the tree without loops, we develop a simple model that incorporates the basic fluid dynamics features of the system. For large trees, the results of the model indicate that the distribution of flow at the outlet branches can be described by a self-affine landscape. Finally, we argue that the nonuniform partitioning of flow found for the structure without loops may contribute to the morphogenesis and functioning of the bronchial tree.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699795"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699795"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699795; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699795]").text(description); $(".js-view-count[data-work-id=31699795]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699795; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699795']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699795, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699795]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699795,"title":"Fluid flow through ramified structures","translated_title":"","metadata":{"abstract":"We investigate the fluid flow through two-dimensional ramified structures by direct simulation of the Navier-Stokes equations. We show that for trees with n generations, the flow distribution strongly depends on the Reynolds number Re. Specifically, for a tree without loops the flow becomes highly heterogeneous at high Re. For a tree with loops, on the other hand, the flow distribution tends to be more uniform at increased Re conditions. We show that these apparently contradictory behaviors have the same origin, namely, the effect of inertia on the momentum transport in the channels of the ramified geometry. In order to simulate the propagation of the flow imbalance throughout the tree without loops, we develop a simple model that incorporates the basic fluid dynamics features of the system. For large trees, the results of the model indicate that the distribution of flow at the outlet branches can be described by a self-affine landscape. Finally, we argue that the nonuniform partitioning of flow found for the structure without loops may contribute to the morphogenesis and functioning of the bronchial tree.","publication_date":{"day":null,"month":null,"year":1999,"errors":{}},"publication_name":"Physical Review E"},"translated_abstract":"We investigate the fluid flow through two-dimensional ramified structures by direct simulation of the Navier-Stokes equations. We show that for trees with n generations, the flow distribution strongly depends on the Reynolds number Re. Specifically, for a tree without loops the flow becomes highly heterogeneous at high Re. For a tree with loops, on the other hand, the flow distribution tends to be more uniform at increased Re conditions. We show that these apparently contradictory behaviors have the same origin, namely, the effect of inertia on the momentum transport in the channels of the ramified geometry. In order to simulate the propagation of the flow imbalance throughout the tree without loops, we develop a simple model that incorporates the basic fluid dynamics features of the system. For large trees, the results of the model indicate that the distribution of flow at the outlet branches can be described by a self-affine landscape. Finally, we argue that the nonuniform partitioning of flow found for the structure without loops may contribute to the morphogenesis and functioning of the bronchial tree.","internal_url":"https://www.academia.edu/31699795/Fluid_flow_through_ramified_structures","translated_internal_url":"","created_at":"2017-03-03T13:00:10.868-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Fluid_flow_through_ramified_structures","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":8067,"name":"Heat Transfer","url":"https://www.academia.edu/Documents/in/Heat_Transfer"},{"id":16496,"name":"Fluid Dynamics","url":"https://www.academia.edu/Documents/in/Fluid_Dynamics"},{"id":215076,"name":"Fluid flow","url":"https://www.academia.edu/Documents/in/Fluid_flow"},{"id":1008960,"name":"Reynolds Number","url":"https://www.academia.edu/Documents/in/Reynolds_Number"}],"urls":[]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699791"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699791/Self_organized_percolation_growth_in_regular_and_disordered_lattices"><img alt="Research paper thumbnail of Self-organized percolation growth in regular and disordered lattices" class="work-thumbnail" src="https://attachments.academia-assets.com/52015343/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699791/Self_organized_percolation_growth_in_regular_and_disordered_lattices">Self-organized percolation growth in regular and disordered lattices</a></div><div class="wp-workCard_item"><span>Physica A: Statistical Mechanics and its Applications</span><span>, 2002</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7304c151f822cbeb9f0da06a85f28a85" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52015343,"asset_id":31699791,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52015343/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699791"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699791"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699791; 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By controlling the number of sites or bonds in the growth front of the aggregate, the system is spontaneously driven to a stationary state that corresponds to approximately the percolation threshold of the lattice topology and percolation process. The SOP model is applied here to site and bond percolation in several regular lattices in two and three dimensions (triangular, honeycomb and simple cubic), as well as in a disordered network (Voronoi-Delaunai). Based on these results, we propose the use of this growth algorithm as a plausible model to describe the dynamics and the anomalous geometrical properties of some natural processes.","publication_date":{"day":null,"month":null,"year":2002,"errors":{}},"publication_name":"Physica A: Statistical Mechanics and its Applications","grobid_abstract_attachment_id":52015343},"translated_abstract":null,"internal_url":"https://www.academia.edu/31699791/Self_organized_percolation_growth_in_regular_and_disordered_lattices","translated_internal_url":"","created_at":"2017-03-03T13:00:10.492-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":52015343,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015343/thumbnails/1.jpg","file_name":"s0378-4371_2802_2900833-620170303-30380-1yr8pil.pdf","download_url":"https://www.academia.edu/attachments/52015343/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Self_organized_percolation_growth_in_reg.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015343/s0378-4371_2802_2900833-620170303-30380-1yr8pil-libre.pdf?1488575423=\u0026response-content-disposition=attachment%3B+filename%3DSelf_organized_percolation_growth_in_reg.pdf\u0026Expires=1732759413\u0026Signature=agixlSIwCX8t0KNJyuV05eWWfE981VG0yOMibVxVRziwS85pa4MmYSnYRhrU~laNjMz5PY2waT807c-QoKs8dQGIuWx77AZcXu0t01ig~bQ8vZcnz34Y~zAICzd5z0DvbIVahvqRPnEmBvwZlIM9GGNUfdYsb8g5DO6T9SgoH~4nf2SfaH3zMq8tuBCZ5XM-ru9DtjDp14tTdzngSHrGezWJNriQL043sYO0-iNvpeQ7mgJ50tmazjkCbpylnT~C9WZv50ktD03~TUdvDrwrglF8FFHBOmADnejwhWE42bl1-i0P4SHUM9cX-UC9pGuGquREf3iFW4tUnzoYDCKzTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Self_organized_percolation_growth_in_regular_and_disordered_lattices","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[{"id":52015343,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/52015343/thumbnails/1.jpg","file_name":"s0378-4371_2802_2900833-620170303-30380-1yr8pil.pdf","download_url":"https://www.academia.edu/attachments/52015343/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Self_organized_percolation_growth_in_reg.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/52015343/s0378-4371_2802_2900833-620170303-30380-1yr8pil-libre.pdf?1488575423=\u0026response-content-disposition=attachment%3B+filename%3DSelf_organized_percolation_growth_in_reg.pdf\u0026Expires=1732759413\u0026Signature=agixlSIwCX8t0KNJyuV05eWWfE981VG0yOMibVxVRziwS85pa4MmYSnYRhrU~laNjMz5PY2waT807c-QoKs8dQGIuWx77AZcXu0t01ig~bQ8vZcnz34Y~zAICzd5z0DvbIVahvqRPnEmBvwZlIM9GGNUfdYsb8g5DO6T9SgoH~4nf2SfaH3zMq8tuBCZ5XM-ru9DtjDp14tTdzngSHrGezWJNriQL043sYO0-iNvpeQ7mgJ50tmazjkCbpylnT~C9WZv50ktD03~TUdvDrwrglF8FFHBOmADnejwhWE42bl1-i0P4SHUM9cX-UC9pGuGquREf3iFW4tUnzoYDCKzTg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":318,"name":"Mathematical Physics","url":"https://www.academia.edu/Documents/in/Mathematical_Physics"},{"id":518,"name":"Quantum Physics","url":"https://www.academia.edu/Documents/in/Quantum_Physics"},{"id":50071,"name":"Percolation","url":"https://www.academia.edu/Documents/in/Percolation"},{"id":54961,"name":"Growth","url":"https://www.academia.edu/Documents/in/Growth"},{"id":299563,"name":"Self Organization","url":"https://www.academia.edu/Documents/in/Self_Organization"},{"id":385916,"name":"Percolation threshold","url":"https://www.academia.edu/Documents/in/Percolation_threshold"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699790"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699790/Essential_Oil_of_Croton_Nepetaefolius_and_Its_Main_Constituent_1_8_CINEOLE_Block_Excitability_of_Rat_Sciatic_Nerve_in_Vitro"><img alt="Research paper thumbnail of Essential Oil of Croton Nepetaefolius and Its Main Constituent, 1,8-CINEOLE, Block Excitability of Rat Sciatic Nerve in Vitro" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699790/Essential_Oil_of_Croton_Nepetaefolius_and_Its_Main_Constituent_1_8_CINEOLE_Block_Excitability_of_Rat_Sciatic_Nerve_in_Vitro">Essential Oil of Croton Nepetaefolius and Its Main Constituent, 1,8-CINEOLE, Block Excitability of Rat Sciatic Nerve in Vitro</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Pharmacology and Physiology</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8-cineole, on the compound action potential (CAP) of nerve were investigated. 2. Experiments were performed in sciatic nerves dissected from Wistar rats, mounted in a moist chamber and stimulated at a frequency of 0.2 Hz, with electric pulses of 100 micros duration at 20-40 V. Evoked CAP were displayed on an oscilloscope and recorded on a computer. The CAP control parameters were as follows: peak-to-peak amplitude 8.1 +/- 0.6 mV (n = 15); conduction velocity 83.3 +/- 4.2 m/s (n = 15); chronaxie 58.0 +/- 6.8 msec (n = 6); and rheobase 2.8 +/- 0.1 V (n = 6). 3. Lower concentrations of EOCN (100 and 300 microg/mL) and 1,8-cineole (153 and 307 microg/mL; i.e. 1 and 2 mmol/L, respectively) had no significant effects on CAP control parameters throughout the entire recording period. However, at the end of 180 min exposure of the nerve to the drug, peak-to-peak amplitude was significantly (P &amp;lt; 0.05) reduced to 27.4 +/- 6.7 and 1.7 +/- 0.8% of control values by 500 and 1000 microg/mL EOCN, respectively (n = 6), and to 76.5 +/- 4.4, 70.0 +/- 3.9 and 14.8 +/- 4.1% of control values by 614, 920 and 1227 microg/mL (i.e. 4, 6 and 8 mmol/L) 1,8-cineole, respectively (n = 6). Regarding conduction velocity, at the end of the 180 min exposure period, this parameter was significantly reduced to 85.8 +/- 7.3 and 48.7 +/- 12.3% (n = 6) of control values by 500 and 1000 microg/mL EOCN, respectively, and to 86.4 +/- 4.5 and 76.1 +/- 5.2% (n = 6) by 920 and 1227 microg/mL 1,8-cineole, respectively. Chronaxie and rheobase were significantly increased by the higher concentrations of both EOCN and 1,8-cineole. 4. It is concluded that EOCN and its main constituent 1,8-cineole block nerve excitability in a concentration-dependent manner, an effect that was totally reversible with 1,8-cineole but not with EOCN. This suggests that other constituents of EOCN, in addition to 1,8-cineole, may contribute to the mediation of this effect of EOCN.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699790"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699790"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699790; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699790]").text(description); $(".js-view-count[data-work-id=31699790]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699790; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699790']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699790, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699790]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699790,"title":"Essential Oil of Croton Nepetaefolius and Its Main Constituent, 1,8-CINEOLE, Block Excitability of Rat Sciatic Nerve in Vitro","translated_title":"","metadata":{"abstract":"1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8-cineole, on the compound action potential (CAP) of nerve were investigated. 2. Experiments were performed in sciatic nerves dissected from Wistar rats, mounted in a moist chamber and stimulated at a frequency of 0.2 Hz, with electric pulses of 100 micros duration at 20-40 V. Evoked CAP were displayed on an oscilloscope and recorded on a computer. The CAP control parameters were as follows: peak-to-peak amplitude 8.1 +/- 0.6 mV (n = 15); conduction velocity 83.3 +/- 4.2 m/s (n = 15); chronaxie 58.0 +/- 6.8 msec (n = 6); and rheobase 2.8 +/- 0.1 V (n = 6). 3. Lower concentrations of EOCN (100 and 300 microg/mL) and 1,8-cineole (153 and 307 microg/mL; i.e. 1 and 2 mmol/L, respectively) had no significant effects on CAP control parameters throughout the entire recording period. However, at the end of 180 min exposure of the nerve to the drug, peak-to-peak amplitude was significantly (P \u0026amp;lt; 0.05) reduced to 27.4 +/- 6.7 and 1.7 +/- 0.8% of control values by 500 and 1000 microg/mL EOCN, respectively (n = 6), and to 76.5 +/- 4.4, 70.0 +/- 3.9 and 14.8 +/- 4.1% of control values by 614, 920 and 1227 microg/mL (i.e. 4, 6 and 8 mmol/L) 1,8-cineole, respectively (n = 6). Regarding conduction velocity, at the end of the 180 min exposure period, this parameter was significantly reduced to 85.8 +/- 7.3 and 48.7 +/- 12.3% (n = 6) of control values by 500 and 1000 microg/mL EOCN, respectively, and to 86.4 +/- 4.5 and 76.1 +/- 5.2% (n = 6) by 920 and 1227 microg/mL 1,8-cineole, respectively. Chronaxie and rheobase were significantly increased by the higher concentrations of both EOCN and 1,8-cineole. 4. It is concluded that EOCN and its main constituent 1,8-cineole block nerve excitability in a concentration-dependent manner, an effect that was totally reversible with 1,8-cineole but not with EOCN. This suggests that other constituents of EOCN, in addition to 1,8-cineole, may contribute to the mediation of this effect of EOCN.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Clinical and Experimental Pharmacology and Physiology"},"translated_abstract":"1. The effects of the essential oil of Croton nepetaefolius (EOCN) and its major constituent, 1,8-cineole, on the compound action potential (CAP) of nerve were investigated. 2. Experiments were performed in sciatic nerves dissected from Wistar rats, mounted in a moist chamber and stimulated at a frequency of 0.2 Hz, with electric pulses of 100 micros duration at 20-40 V. Evoked CAP were displayed on an oscilloscope and recorded on a computer. The CAP control parameters were as follows: peak-to-peak amplitude 8.1 +/- 0.6 mV (n = 15); conduction velocity 83.3 +/- 4.2 m/s (n = 15); chronaxie 58.0 +/- 6.8 msec (n = 6); and rheobase 2.8 +/- 0.1 V (n = 6). 3. Lower concentrations of EOCN (100 and 300 microg/mL) and 1,8-cineole (153 and 307 microg/mL; i.e. 1 and 2 mmol/L, respectively) had no significant effects on CAP control parameters throughout the entire recording period. However, at the end of 180 min exposure of the nerve to the drug, peak-to-peak amplitude was significantly (P \u0026amp;lt; 0.05) reduced to 27.4 +/- 6.7 and 1.7 +/- 0.8% of control values by 500 and 1000 microg/mL EOCN, respectively (n = 6), and to 76.5 +/- 4.4, 70.0 +/- 3.9 and 14.8 +/- 4.1% of control values by 614, 920 and 1227 microg/mL (i.e. 4, 6 and 8 mmol/L) 1,8-cineole, respectively (n = 6). Regarding conduction velocity, at the end of the 180 min exposure period, this parameter was significantly reduced to 85.8 +/- 7.3 and 48.7 +/- 12.3% (n = 6) of control values by 500 and 1000 microg/mL EOCN, respectively, and to 86.4 +/- 4.5 and 76.1 +/- 5.2% (n = 6) by 920 and 1227 microg/mL 1,8-cineole, respectively. Chronaxie and rheobase were significantly increased by the higher concentrations of both EOCN and 1,8-cineole. 4. It is concluded that EOCN and its main constituent 1,8-cineole block nerve excitability in a concentration-dependent manner, an effect that was totally reversible with 1,8-cineole but not with EOCN. This suggests that other constituents of EOCN, in addition to 1,8-cineole, may contribute to the mediation of this effect of EOCN.","internal_url":"https://www.academia.edu/31699790/Essential_Oil_of_Croton_Nepetaefolius_and_Its_Main_Constituent_1_8_CINEOLE_Block_Excitability_of_Rat_Sciatic_Nerve_in_Vitro","translated_internal_url":"","created_at":"2017-03-03T13:00:10.344-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Essential_Oil_of_Croton_Nepetaefolius_and_Its_Main_Constituent_1_8_CINEOLE_Block_Excitability_of_Rat_Sciatic_Nerve_in_Vitro","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":60898253,"first_name":"Francisco","middle_initials":null,"last_name":"Cavalcante","page_name":"FranciscoCavalcante","domain_name":"bnfghhtrhtbnhfdhtryht","created_at":"2017-03-02T09:12:00.368-08:00","display_name":"Francisco Cavalcante","url":"https://bnfghhtrhtbnhfdhtryht.academia.edu/FranciscoCavalcante"},"attachments":[],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":2007,"name":"Electrophysiology","url":"https://www.academia.edu/Documents/in/Electrophysiology"},{"id":48465,"name":"Essential Oil","url":"https://www.academia.edu/Documents/in/Essential_Oil"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"},{"id":303570,"name":"Croton Oil","url":"https://www.academia.edu/Documents/in/Croton_Oil"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":561957,"name":"Sciatic Nerve","url":"https://www.academia.edu/Documents/in/Sciatic_Nerve"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats"},{"id":835567,"name":"Monoterpenes","url":"https://www.academia.edu/Documents/in/Monoterpenes"},{"id":955727,"name":"Action Potentials","url":"https://www.academia.edu/Documents/in/Action_Potentials"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31699789"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31699789/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips"><img alt="Research paper thumbnail of Effects of collagenase and elastase on the mechanical properties of lung tissue strips" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31699789/Effects_of_collagenase_and_elastase_on_the_mechanical_properties_of_lung_tissue_strips">Effects of collagenase and elastase on the mechanical properties of lung tissue strips</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspond...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). The costs of ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31699789"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31699789"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31699789; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31699789]").text(description); $(".js-view-count[data-work-id=31699789]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31699789; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31699789']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31699789, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31699789]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31699789,"title":"Effects of collagenase and elastase on the mechanical properties of lung tissue strips","translated_title":"","metadata":{"abstract":"... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). The costs of ...","publication_date":{"day":null,"month":null,"year":2000,"errors":{}}},"translated_abstract":"... in parallel. Suki et al. (35 ... Footnotes. Address for reprint requests and other correspondence: B. Suki, Dept. Biomedical Engineering, Boston Univ., 44 Cummington St., Boston, MA 02215 (E-mail: bsuki{at}bu.edu). 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FSA Cavalcante,* RN Costa Filho, J. Ribeiro Filho, CAS de Almeida, and VN Freire Departamento...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... FSA Cavalcante,* RN Costa Filho, J. Ribeiro Filho, CAS de Almeida, and VN Freire Departamento de Fısica, Universidade Federal do Ceará, Centro ... At this point, it is worth highlighting that the famous original publications of Schrödinger allow us to ponder the assumption of a ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31680283"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31680283"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31680283; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=31680283]").text(description); $(".js-view-count[data-work-id=31680283]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 31680283; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='31680283']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 31680283, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=31680283]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":31680283,"title":"Form of the quantum kinetic-energy operator with spatially varying effective mass","translated_title":"","metadata":{"abstract":"... FSA Cavalcante,* RN Costa Filho, J. Ribeiro Filho, CAS de Almeida, and VN Freire Departamento de Fısica, Universidade Federal do Ceará, Centro ... At this point, it is worth highlighting that the famous original publications of Schrödinger allow us to ponder the assumption of a ...","publication_date":{"day":null,"month":null,"year":1997,"errors":{}},"publication_name":"Physical Review B"},"translated_abstract":"... FSA Cavalcante,* RN Costa Filho, J. Ribeiro Filho, CAS de Almeida, and VN Freire Departamento de Fısica, Universidade Federal do Ceará, Centro ... At this point, it is worth highlighting that the famous original publications of Schrödinger allow us to ponder the assumption of a ...","internal_url":"https://www.academia.edu/31680283/Form_of_the_quantum_kinetic_energy_operator_with_spatially_varying_effective_mass","translated_internal_url":"","created_at":"2017-03-02T09:13:16.026-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":60898253,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":27852122,"work_id":31680283,"tagging_user_id":60898253,"tagged_user_id":null,"co_author_invite_id":6090381,"email":"a***a@prominent.com.br","display_order":0,"name":"Carlos Almeida","title":"Form of the quantum kinetic-energy operator with spatially varying effective mass"},{"id":27852129,"work_id":31680283,"tagging_user_id":60898253,"tagged_user_id":1292553,"co_author_invite_id":null,"email":"r***a@hotmail.com","affiliation":"Universidade Estadual do Ceara","display_order":4194304,"name":"Raimundo Costa","title":"Form of the quantum kinetic-energy operator with spatially varying effective mass"},{"id":27852130,"work_id":31680283,"tagging_user_id":60898253,"tagged_user_id":59732441,"co_author_invite_id":null,"email":"f***s@gmail.com","display_order":6291456,"name":"JOSE GOMES RIBEIRO","title":"Form of the quantum kinetic-energy operator with spatially varying effective mass"},{"id":27852131,"work_id":31680283,"tagging_user_id":60898253,"tagged_user_id":54107551,"co_author_invite_id":null,"email":"v***s@gmail.com","display_order":7340032,"name":"Ramos Ferreira","title":"Form of the quantum kinetic-energy operator with spatially varying effective mass"},{"id":27892044,"work_id":31680283,"tagging_user_id":60898253,"tagged_user_id":null,"co_author_invite_id":6098148,"email":"r***o@hotmail.com","display_order":7864320,"name":"R. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="31680282"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/31680282/Mechanical_interactions_between_collagen_and_proteoglycans_implications_for_the_stability_of_lung_tissue"><img alt="Research paper thumbnail of Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue" class="work-thumbnail" src="https://attachments.academia-assets.com/52000116/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/31680282/Mechanical_interactions_between_collagen_and_proteoglycans_implications_for_the_stability_of_lung_tissue">Mechanical interactions between collagen and proteoglycans: implications for the stability of lung tissue</a></div><div class="wp-workCard_item"><span>Journal of Applied Physiology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4b72c3bd93c3e3d783baadf108af0b21" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":52000116,"asset_id":31680282,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/52000116/download_file?st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&st=MTczMjc1NTgxMyw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="31680282"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="31680282"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 31680282; 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Collagen and elastin are thought to dominate the elasticity of the connective tissue including lung parenchyma. The glycosaminoglycans on the proteoglycans may also play a role because osmolarity of interstitial fluid can alter the repulsive forces on the negatively charged glycosaminoglycans, allowing them to collapse or inflate, which can affect the stretching and folding pattern of the fibers. Hence, we hypothesized that the elasticity of lung tissue arises primarily from 1) the topology of the collagen-elastin network and 2) the mechanical interaction between proteoglycans and fibers. We measured the quasi-static, uniaxial stress-strain curves of lung tissue sheets in hypotonic, normal, and hypertonic solutions. We found that the stress-strain curve was sensitive to osmolarity, but this sensitivity decreased after proteoglycan digestion. Images of immunofluorescently labeled collagen networks showed that the fibers follow the alveolar walls that form a hexagonal-like structure. Despite the large heterogeneity, the aspect ratio of the hexagons at 30% uniaxial strain increased linearly with osmolarity. We developed a two-dimensional hexagonal network model of the alveolar structure incorporating the mechanical properties of the collagen-elastin fibers and their interaction with proteoglycans. The model accounted for the stressstrain curves observed under all experimental conditions. The model also predicted how aspect ratio changed with osmolarity and strain, which allowed us to estimate the Young's modulus of a single alveolar wall and a collagen fiber. We therefore identify a novel and important role for the proteoglycans: they stabilize the collagenelastin network of connective tissues and contribute to lung elasticity and alveolar stability at low to medium lung volumes. . Collagen-labeled unstretched tissue at a higher magnification. Note that wavy collagen fibers are running nearly parallel in the alveolar walls. 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