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menu-item-type-post_type menu-item-object-page menu-item-4072"><a href="https://seqwell.com/blog/"><span>Blog</span></a></li> </ul> </li> <li id="menu-item-4183" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-4183"><a href="https://seqwell.com/support/"><span>Support</span></a></li> </ul> </nav> <nav class="secondary"> <ul> <li id="menu-item-3944" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-3944"><a href="https://seqwell.com/contact/"><span>Contact Sales</span></a></li> </ul> </nav> <nav class="primary account"> <ul> <li id="" class="menu-item menu-item-type-post_type menu-item-object-page menu-item-has-children"><a href="/my-account/"><span>Login</span></a> </ul> </nav> </div> </div> </div> <header class="page-header"> <div class="contain wide"> <div class="content-wrap fade in-left"> <h3></h3> <h1><strong>Bring Confidence to a World of Gene Editing QC Uncertainty </strong></h1> </div> </div> </header><section class="content-section gray" id="content1"> <div class="contain wide"> <div class="content-wrap"> <h2>How confident are you in your gene editing results?</h2> <p>Gene editing tools like CRISPR, transcription activator-like effector nucleases (TALENs) and zinc finger nucleases (ZFNs) have the potential to transform lives. Performing gene editing quality control (QC) to eliminate errors, however, is crucial to ensuring research integrity and patient safety.</p> <p>seqWell offers several workflow solutions to drive <strong>simple</strong>, <strong>scalable</strong> and <strong>reliable</strong> sequence analysis to accelerate your gene editing efforts with peace of mind.</p> <ul> <li><a href="https://seqwell.com/tagify-umi-reagents/">Tagify</a> adapter-loaded transposases for On-target/Off-target gene editing QC</li> <li><a href="https://seqwell.com/expressplex-2-0-library-prep-kit/">ExpressPlex 2.0</a> library preparation for high throughput gene editing construct screening</li> </ul> </div> </div> <div class="contain wide"> <div class="col-1-2 content-wrap"> <p><a href="#content5"><img fetchpriority="high" decoding="async" class="aligncenter wp-image-5870 size-medium" src="https://seqwell.com/wp-content/uploads/2024/06/Construct-Screening-300x258.png" alt="" width="300" height="258" srcset="https://seqwell.com/wp-content/uploads/2024/06/Construct-Screening-300x258.png 300w, https://seqwell.com/wp-content/uploads/2024/06/Construct-Screening-1024x882.png 1024w, https://seqwell.com/wp-content/uploads/2024/06/Construct-Screening-768x661.png 768w, https://seqwell.com/wp-content/uploads/2024/06/Construct-Screening-600x517.png 600w, https://seqwell.com/wp-content/uploads/2024/06/Construct-Screening.png 1201w" sizes="(max-width: 300px) 100vw, 300px" /></a></p> </div> <div class="col-1-2 content-wrap right"> <p><a href="#content2"><img decoding="async" class="aligncenter wp-image-5871 size-medium" src="https://seqwell.com/wp-content/uploads/2024/06/On-target-Off-target-QC-300x245.png" alt="" width="300" height="245" srcset="https://seqwell.com/wp-content/uploads/2024/06/On-target-Off-target-QC-300x245.png 300w, https://seqwell.com/wp-content/uploads/2024/06/On-target-Off-target-QC-1024x835.png 1024w, https://seqwell.com/wp-content/uploads/2024/06/On-target-Off-target-QC-768x626.png 768w, https://seqwell.com/wp-content/uploads/2024/06/On-target-Off-target-QC-600x489.png 600w, https://seqwell.com/wp-content/uploads/2024/06/On-target-Off-target-QC.png 1201w" sizes="(max-width: 300px) 100vw, 300px" /></a></p> </div> </div> </section> <section class="content-section white" id="content2"> <div class="contain wide flex"> <div class="col-1-2 content-wrap"> <h2><strong>On-target, Off-target Gene Editing QC</strong></h2> <h3><a href="https://seqwell.com/tagify-umi-reagents/">Tagify</a> Adapter-Loaded Transposase for Reliable Tagmentation</h3> <p>On- and off-target gene editing events can take many forms including small and large insertions and deletions, inversions and translocations – all of which must be characterized. The development of standardized gene editing QC methods, however, is in its infancy, particularly for off-target analysis. Researchers must sort through a variety of published and unpublished methods, often facing a lack of consistent sources of quality reagents.</p> <p>Ensure the critical reagents in your tagmentation-based gene editing QC assays provide the quality, scalability, and reliability that you need. <a href="https://seqwell.com/tagify-umi-reagents/"><strong>Tagify reagents</strong></a> are fully-QC’ed, ready-to-use or custom-loaded hyperactive Tn5 or TnX – our next-generation transposase.</p> <p>Tagify reagents are compatible with gene editing applications* like UDiTaS, RGEN, TTIS-seq, CHANGE-seq and others.</p> <p>*Some transposase-based methods require licenses for use</p> </div> <div class="col-1-2 content-wrap right"> <div style="width: 1920px;" class="wp-video"> <video class="wp-video-shortcode" id="video-5010-1" width="1920" height="1080" preload="metadata" controls="controls"><source type="video/mp4" src="https://seqwell.com/wp-content/uploads/2024/06/seqWell-Tagify-for-Gene-Editing.mp4?_=1" /><a href="https://seqwell.com/wp-content/uploads/2024/06/seqWell-Tagify-for-Gene-Editing.mp4">http://seqwell.com/wp-content/uploads/2024/06/seqWell-Tagify-for-Gene-Editing.mp4</a></video></div> </div> </div> </section> <section class="content-section blue" id="content3"> <div class="contain wide"> <div class="content-wrap"> <h2 style="text-align: left;">Shorten the Gene Editing QC Process</h2> <p>“We’ve been asking for this. What’s great about Tagify is that it allows you to look at a specific place in the gene, and adapter concentration is taken care of. This system is really important because it provides us this opportunity to assess the consequences of gene editing in a semi-unbiased way. It shortens our process, makes it much more controlled, and lessens the amount of reagents we need to use.”</p> <p><strong>– Athea Vichas, Ph.D., Senior Principal Scientist of Gene Editing Analytical Development, Bristol Myers Squibb</strong></p> </div> </div> </section> <section class="content-section gray" id="content4"> <div class="contain wide flex"> <div class="image-wrap fade right in-left col-1-2"> <img src="https://seqwell.com/wp-content/uploads/2023/02/FEB23-EDITAS-GRAPHIC-C2V01-BLOG-IMAGE-1200px-600px-1024x512.jpg" alt="Assessing CRISPR On-Target Editing and Structural Changes with UDiTaS Using Tagify Reagents" /> </div> <div class="content-wrap col-1-2"> <h2>WEBINAR</h2> <h3>Assessing CRISPR On-Target Editing and Structural Changes</h3> <p>In this webinar, Dr. Giannoukos highlighted how her team combined a custom Tagify reagent with their UDiTaS method to measure large deletions and inversions at the CEP290 editing site.</p> <p> </p> <p><a style="font-weight: bold; font-size: 16px; text-decoration: none; background-color: #6cc249; padding: 10px 18px; border-radius: 5px; color: white; margin-top: 10px;" href="https://seqwell.com/webinar-uditas/" rel="noopener">Watch Video</a></p> </div> </div> </section> <section class="content-section white" id="content5"> <div class="contain wide"> <div class="content-wrap"> <h2><strong>Gene Editing Construct Confirmation</strong></h2> <h3><a href="https://seqwell.com/expressplex-2-0-library-prep-kit/">ExpressPlex 2.0</a> Library Prep Kits for High Throughput Construct Screening</h3> <p>Shift your benchtop NGS sequencer into overdrive to verify your gene editing constructs at unprecedented speed using 90-minute workflows that are optimized for simplicity, automation compatibility, and massive sample multiplexing of up to 6144 samples in a single sequencing run. <a href="https://seqwell.com/expressplex-2-0-library-prep-kit/">ExpressPlex</a> workflows are compatible with rolling circle amplification (RCA) and colony PCR to further accelerate colony-to-sequence data to less than 24 hours.</p> </div> </div> </section> <section class="content-section gray" id="content6"> <div class="contain wide"> <div class="image-wrap fade in-right col-1-2"> <img src="https://seqwell.com/wp-content/uploads/2023/03/MAR-23-OCTANT-WEBINAR-VIDEO-THMB-V04-1200px-675px-Tighter-top-bar-1024x576-1.jpg" alt="" /> </div> <div class="content-wrap right col-1-2"> <h2>WEBINAR</h2> <h3>High-throughput Construct Screening</h3> <p>The game-changing capabilities of ExpressPlex were highlighted in a webinar collaboration with the synthetic biology team from Octant Bio, a drug discovery company located in Emeryville, CA. Octant’s Henry Chan, PhD (Synthetic Biology Lead) and Bryan Jiang (Research Associate) discussed the application of ExpressPlex to the high-throughput plasmid sequencing platform that powers Octant’s therapeutic discovery platform.</p> <p> </p> <p><a style="font-weight: bold; font-size: 16px; text-decoration: none; background-color: #6cc249; padding: 10px 18px; border-radius: 5px; color: white; margin-top: 10px;" href="https://seqwell.com/webinar-octant/" rel="noopener">Watch Video</a></p> </div> </div> </section> <section class="content-section blue" id="content7"> <div class="contain wide"> <div class="content-wrap"> <h2>ExpressPlex is a Game Changer</h2> <p class="p1">“ExpressPlex is literally faster than Sanger. This changes everything for us. Basically, taking a two-day process to one day dramatically shortens time to data.”</p> <p class="p1"><strong>– Henry Chan, Ph.D., Synthetic Biology Lead, Octant Bio</strong></p> </div> </div> </section> <section class="content-section white" id="content8"> <div class="contain wide"> <div class="content-wrap"> <h1 style="text-align: center;">Learn More With These Blogs</h1> </div> </div> </section> <section class="content-section white" id="content9"> <div class="contain wide"> <div class="col-1-2 content-wrap"> <p><a href="https://seqwell.com/improve-gene-editing-with-tn5-transposase/"><img loading="lazy" decoding="async" class="aligncenter wp-image-4971 size-large" src="https://seqwell.com/wp-content/uploads/2023/04/Gene-Editing-V01-BLOG-IMAGE-1200px-600px-1024x512.jpg" alt="Improve Gene Editing with Tn5 Transposase" width="1024" height="512" srcset="https://seqwell.com/wp-content/uploads/2023/04/Gene-Editing-V01-BLOG-IMAGE-1200px-600px-1024x512.jpg 1024w, https://seqwell.com/wp-content/uploads/2023/04/Gene-Editing-V01-BLOG-IMAGE-1200px-600px-300x150.jpg 300w, https://seqwell.com/wp-content/uploads/2023/04/Gene-Editing-V01-BLOG-IMAGE-1200px-600px-768x384.jpg 768w, https://seqwell.com/wp-content/uploads/2023/04/Gene-Editing-V01-BLOG-IMAGE-1200px-600px-600x300.jpg 600w, https://seqwell.com/wp-content/uploads/2023/04/Gene-Editing-V01-BLOG-IMAGE-1200px-600px.jpg 1200w" sizes="(max-width: 1024px) 100vw, 1024px" /></a></p> <h3 style="text-align: center;">Improve Gene Editing With Tn5 Transposase</h3> <p style="text-align: center;"><a style="font-weight: bold; font-size: 16px; text-decoration: none; background-color: #6cc249; padding: 10px 18px; border-radius: 5px; color: white; margin-top: 10px;" href="https://seqwell.com/improve-gene-editing-with-tn5-transposase/" rel="noopener">Read Article</a></p> </div> <div class="col-1-2 content-wrap right"> <p><img loading="lazy" decoding="async" class="aligncenter wp-image-5872 size-large" src="https://seqwell.com/wp-content/uploads/2023/05/Upstream_Downstream-gene-editing-scaled-e1717542719510-1024x512.jpg" alt="" width="1024" height="512" srcset="https://seqwell.com/wp-content/uploads/2023/05/Upstream_Downstream-gene-editing-scaled-e1717542719510-1024x512.jpg 1024w, https://seqwell.com/wp-content/uploads/2023/05/Upstream_Downstream-gene-editing-scaled-e1717542719510-300x150.jpg 300w, https://seqwell.com/wp-content/uploads/2023/05/Upstream_Downstream-gene-editing-scaled-e1717542719510-768x384.jpg 768w, https://seqwell.com/wp-content/uploads/2023/05/Upstream_Downstream-gene-editing-scaled-e1717542719510-1536x768.jpg 1536w, https://seqwell.com/wp-content/uploads/2023/05/Upstream_Downstream-gene-editing-scaled-e1717542719510-2048x1024.jpg 2048w, https://seqwell.com/wp-content/uploads/2023/05/Upstream_Downstream-gene-editing-scaled-e1717542719510-600x300.jpg 600w" sizes="(max-width: 1024px) 100vw, 1024px" /></p> <h3 style="text-align: center;">Upstream, Downstream, or Both: Powerful Tools for Gene Editing QC</h3> <p style="text-align: center;"><a style="font-weight: bold; font-size: 16px; text-decoration: none; background-color: #6cc249; padding: 10px 18px; border-radius: 5px; color: white; margin-top: 10px;" href="https://seqwell.com/upstream-downstream-or-both-a-powerful-tool-for-gene-editing-qc/" rel="noopener">Read Article</a></p> </div> </div> </section> <section class="content-section blue" id="content10"> <div class="contain narrow"> <div class="cta-block fade in-up"> <div class="flex"> <header class="content-wrap"> <p>seqWell’s “workflow engineering” approach builds on our core reagent expertise to create streamlined products that deliver cutting-edge integrated workflows. 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