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li.mfn-megamenu-cols-6{width:16.66%}#Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto;border-width:0 1px 0 0}#Top_bar .menu > li > ul.mfn-megamenu > li:last-child > ul{border:0}#Top_bar .menu > li > ul.mfn-megamenu > li > ul li{width:auto}#Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400;background:none}#Top_bar .menu > li > ul.mfn-megamenu a .menu-arrow{display:none}.menuo-right #Top_bar .menu > li > ul.mfn-megamenu{left:0;width:98%!important;margin:0 1%;padding:20px 0}.menuo-right #Top_bar .menu > li > ul.mfn-megamenu-bg{box-sizing:border-box}#Top_bar .menu > li > ul.mfn-megamenu-bg{padding:20px 166px 20px 20px;background-repeat:no-repeat;background-position:right bottom}.rtl #Top_bar .menu > li > ul.mfn-megamenu-bg{padding-left:166px;padding-right:20px;background-position:left bottom}#Top_bar .menu > li > ul.mfn-megamenu-bg > li{background:none}#Top_bar .menu > li > ul.mfn-megamenu-bg > li a{border:none}#Top_bar .menu > li > ul.mfn-megamenu-bg > li > ul{background:none!important;-webkit-box-shadow:0 0 0 0;-moz-box-shadow:0 0 0 0;box-shadow:0 0 0 0}.mm-vertical #Top_bar .container{position:relative}.mm-vertical #Top_bar .top_bar_left{position:static}.mm-vertical #Top_bar .menu > li ul{box-shadow:0 0 0 0 transparent!important;background-image:none}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu{padding:20px 0}.mm-vertical.header-plain #Top_bar .menu > li > ul.mfn-megamenu{width:100%!important;margin:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li{display:table-cell;float:none!important;width:10%;padding:0 15px;border-right:1px solid rgba(0,0,0,0.05)}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:last-child{border-right-width:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li.hide-border{border-right-width:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a{border-bottom-width:0;padding:9px 15px;line-height:120%}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{font-weight:700}.rtl .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child{border-right-width:0}.rtl .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:last-child{border-right-width:1px}body.header-shop #Top_bar #menu{display:flex!important;background-color:transparent}.header-shop #Top_bar.is-sticky .top_bar_row_second{display:none}.header-plain:not(.menuo-right) #Header .top_bar_left{width:auto!important}.header-stack.header-center #Top_bar #menu{display:inline-block!important}.header-simple #Top_bar #menu{display:none;height:auto;width:300px;bottom:auto;top:100%;right:1px;position:absolute;margin:0}.header-simple #Header a.responsive-menu-toggle{display:block;right:10px}.header-simple #Top_bar #menu > ul{width:100%;float:left}.header-simple #Top_bar #menu ul li{width:100%;padding-bottom:0;border-right:0;position:relative}.header-simple #Top_bar #menu ul li a{padding:0 20px;margin:0;display:block;height:auto;line-height:normal;border:none}.header-simple #Top_bar #menu ul li a:not(.menu-toggle):after{display:none}.header-simple #Top_bar #menu ul li a span{border:none;line-height:44px;display:inline;padding:0}.header-simple #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:44px;height:44px;line-height:44px;font-size:30px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33;transform:unset}.header-simple #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+";position:static}.header-simple #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}.header-simple #Top_bar #menu ul li.hover a{border-bottom:0}.header-simple #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}.header-simple #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin:0!important;width:auto!important;background-image:none}.header-simple #Top_bar #menu ul li ul li{width:100%!important;display:block;padding:0}.header-simple #Top_bar #menu ul li ul li a{padding:0 20px 0 30px}.header-simple #Top_bar #menu ul li ul li a .menu-arrow{display:none}.header-simple #Top_bar #menu ul li ul li a span{padding:0}.header-simple #Top_bar #menu ul li ul li a span:after{display:none!important}.header-simple #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}.header-simple #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}.header-simple #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}.header-simple #Top_bar #menu ul li ul li ul li a{padding:0 20px 0 40px}.rtl.header-simple #Top_bar #menu{left:1px;right:auto}.rtl.header-simple #Top_bar a.responsive-menu-toggle{left:10px;right:auto}.rtl.header-simple #Top_bar #menu ul li.submenu .menu-toggle{left:0;right:auto}.rtl.header-simple #Top_bar #menu ul li ul{left:auto!important;right:0!important}.rtl.header-simple #Top_bar #menu ul li ul li a{padding:0 30px 0 20px}.rtl.header-simple #Top_bar #menu ul li ul li ul li a{padding:0 40px 0 20px}.menu-highlight #Top_bar .menu > li{margin:0 2px}.menu-highlight:not(.header-creative) #Top_bar .menu > li > a{padding:0;-webkit-border-radius:5px;border-radius:5px}.menu-highlight #Top_bar .menu > li > a:after{display:none}.menu-highlight #Top_bar .menu > li > a span:not(.description){line-height:50px}.menu-highlight #Top_bar .menu > li > a span.description{display:none}.menu-highlight.header-stack #Top_bar .menu > li > a{margin:10px 0!important}.menu-highlight.header-stack #Top_bar .menu > li > a span:not(.description){line-height:40px}.menu-highlight.header-simple #Top_bar #menu ul li,.menu-highlight.header-creative #Top_bar #menu ul li{margin:0}.menu-highlight.header-simple #Top_bar #menu ul li > a,.menu-highlight.header-creative #Top_bar #menu ul li > a{-webkit-border-radius:0;border-radius:0}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a{margin:10px 0!important;padding:5px 0!important}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a span{line-height:30px!important}.header-modern.menu-highlight.menuo-right .menu_wrapper{margin-right:20px}.menu-line-below #Top_bar .menu > li > a:not(.menu-toggle):after{top:auto;bottom:-4px}.menu-line-below #Top_bar.is-sticky .menu > li > a:not(.menu-toggle):after{top:auto;bottom:-4px}.menu-line-below-80 #Top_bar:not(.is-sticky) .menu > li > a:not(.menu-toggle):after{height:4px;left:10%;top:50%;margin-top:20px;width:80%}.menu-line-below-80-1 #Top_bar:not(.is-sticky) .menu > li > a:not(.menu-toggle):after{height:1px;left:10%;top:50%;margin-top:20px;width:80%}.menu-link-color #Top_bar .menu > li > a:not(.menu-toggle):after{display:none!important}.menu-arrow-top #Top_bar .menu > li > a:after{background:none repeat scroll 0 0 rgba(0,0,0,0)!important;border-color:#ccc transparent transparent;border-style:solid;border-width:7px 7px 0;display:block;height:0;left:50%;margin-left:-7px;top:0!important;width:0}.menu-arrow-top #Top_bar.is-sticky .menu > li > a:after{top:0!important}.menu-arrow-bottom #Top_bar .menu > li > a:after{background:none!important;border-color:transparent transparent #ccc;border-style:solid;border-width:0 7px 7px;display:block;height:0;left:50%;margin-left:-7px;top:auto;bottom:0;width:0}.menu-arrow-bottom #Top_bar.is-sticky .menu > li > a:after{top:auto;bottom:0}.menuo-no-borders #Top_bar .menu > li > a span{border-width:0!important}.menuo-no-borders #Header_creative #Top_bar .menu > li > a span{border-bottom-width:0}.menuo-no-borders.header-plain #Top_bar a#header_cart,.menuo-no-borders.header-plain #Top_bar a#search_button,.menuo-no-borders.header-plain #Top_bar .wpml-languages,.menuo-no-borders.header-plain #Top_bar a.action_button{border-width:0}.menuo-right #Top_bar .menu_wrapper{float:right}.menuo-right.header-stack:not(.header-center) #Top_bar .menu_wrapper{margin-right:150px}body.header-creative{padding-left:50px}body.header-creative.header-open{padding-left:250px}body.error404,body.under-construction,body.template-blank,body.under-construction.header-rtl.header-creative.header-open{padding-left:0!important;padding-right:0!important}.header-creative.footer-fixed #Footer,.header-creative.footer-sliding #Footer,.header-creative.footer-stick #Footer.is-sticky{box-sizing:border-box;padding-left:50px}.header-open.footer-fixed #Footer,.header-open.footer-sliding #Footer,.header-creative.footer-stick #Footer.is-sticky{padding-left:250px}.header-rtl.header-creative.footer-fixed #Footer,.header-rtl.header-creative.footer-sliding #Footer,.header-rtl.header-creative.footer-stick #Footer.is-sticky{padding-left:0;padding-right:50px}.header-rtl.header-open.footer-fixed #Footer,.header-rtl.header-open.footer-sliding #Footer,.header-rtl.header-creative.footer-stick #Footer.is-sticky{padding-right:250px}#Header_creative{background-color:#fff;position:fixed;width:250px;height:100%;left:-200px;top:0;z-index:9002;-webkit-box-shadow:2px 0 4px 2px rgba(0,0,0,.15);box-shadow:2px 0 4px 2px rgba(0,0,0,.15)}#Header_creative .container{width:100%}#Header_creative .creative-wrapper{opacity:0;margin-right:50px}#Header_creative a.creative-menu-toggle{display:block;width:34px;height:34px;line-height:34px;font-size:22px;text-align:center;position:absolute;top:10px;right:8px;border-radius:3px}.admin-bar #Header_creative a.creative-menu-toggle{top:42px}#Header_creative #Top_bar{position:static;width:100%}#Header_creative #Top_bar .top_bar_left{width:100%!important;float:none}#Header_creative #Top_bar .logo{float:none;text-align:center;margin:15px 0}#Header_creative #Top_bar #menu{background-color:transparent}#Header_creative #Top_bar .menu_wrapper{float:none;margin:0 0 30px}#Header_creative #Top_bar .menu > li{width:100%;float:none;position:relative}#Header_creative #Top_bar .menu > li > a{padding:0;text-align:center}#Header_creative #Top_bar .menu > li > a:after{display:none}#Header_creative #Top_bar .menu > li > a span{border-right:0;border-bottom-width:1px;line-height:38px}#Header_creative #Top_bar .menu li ul{left:100%;right:auto;top:0;box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03);-webkit-box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03)}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu{margin:0;width:700px!important}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu > li > ul{left:0}#Header_creative #Top_bar .menu li ul li a{padding-top:9px;padding-bottom:8px}#Header_creative #Top_bar .menu li ul li ul{top:0}#Header_creative #Top_bar .menu > li > a span.description{display:block;font-size:13px;line-height:28px!important;clear:both}.menuo-arrows #Top_bar .menu > li.submenu > a > span:after{content:unset!important}#Header_creative #Top_bar .top_bar_right{width:100%!important;float:left;height:auto;margin-bottom:35px;text-align:center;padding:0 20px;top:0;-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}#Header_creative #Top_bar .top_bar_right:before{content:none}#Header_creative #Top_bar .top_bar_right .top_bar_right_wrapper{flex-wrap:wrap;justify-content:center}#Header_creative #Top_bar .top_bar_right .top-bar-right-icon,#Header_creative #Top_bar .top_bar_right .wpml-languages,#Header_creative #Top_bar .top_bar_right .top-bar-right-button,#Header_creative #Top_bar .top_bar_right .top-bar-right-input{min-height:30px;margin:5px}#Header_creative #Top_bar .search_wrapper{left:100%;top:auto}#Header_creative #Top_bar .banner_wrapper{display:block;text-align:center}#Header_creative #Top_bar .banner_wrapper img{max-width:100%;height:auto;display:inline-block}#Header_creative #Action_bar{display:none;position:absolute;bottom:0;top:auto;clear:both;padding:0 20px;box-sizing:border-box}#Header_creative #Action_bar .contact_details{width:100%;text-align:center;margin-bottom:20px}#Header_creative #Action_bar .contact_details li{padding:0}#Header_creative #Action_bar .social{float:none;text-align:center;padding:5px 0 15px}#Header_creative #Action_bar .social li{margin-bottom:2px}#Header_creative #Action_bar .social-menu{float:none;text-align:center}#Header_creative #Action_bar .social-menu li{border-color:rgba(0,0,0,.1)}#Header_creative .social li a{color:rgba(0,0,0,.5)}#Header_creative .social li a:hover{color:#000}#Header_creative .creative-social{position:absolute;bottom:10px;right:0;width:50px}#Header_creative .creative-social li{display:block;float:none;width:100%;text-align:center;margin-bottom:5px}.header-creative .fixed-nav.fixed-nav-prev{margin-left:50px}.header-creative.header-open .fixed-nav.fixed-nav-prev{margin-left:250px}.menuo-last #Header_creative #Top_bar .menu li.last ul{top:auto;bottom:0}.header-open #Header_creative{left:0}.header-open #Header_creative .creative-wrapper{opacity:1;margin:0!important}.header-open #Header_creative .creative-menu-toggle,.header-open #Header_creative .creative-social{display:none}.header-open #Header_creative #Action_bar{display:block}body.header-rtl.header-creative{padding-left:0;padding-right:50px}.header-rtl #Header_creative{left:auto;right:-200px}.header-rtl #Header_creative .creative-wrapper{margin-left:50px;margin-right:0}.header-rtl #Header_creative a.creative-menu-toggle{left:8px;right:auto}.header-rtl #Header_creative .creative-social{left:0;right:auto}.header-rtl #Footer #back_to_top.sticky{right:125px}.header-rtl #popup_contact{right:70px}.header-rtl #Header_creative #Top_bar .menu li ul{left:auto;right:100%}.header-rtl #Header_creative #Top_bar .search_wrapper{left:auto;right:100%}.header-rtl .fixed-nav.fixed-nav-prev{margin-left:0!important}.header-rtl .fixed-nav.fixed-nav-next{margin-right:50px}body.header-rtl.header-creative.header-open{padding-left:0;padding-right:250px!important}.header-rtl.header-open #Header_creative{left:auto;right:0}.header-rtl.header-open #Footer #back_to_top.sticky{right:325px}.header-rtl.header-open #popup_contact{right:270px}.header-rtl.header-open .fixed-nav.fixed-nav-next{margin-right:250px}#Header_creative.active{left:-1px}.header-rtl #Header_creative.active{left:auto;right:-1px}#Header_creative.active .creative-wrapper{opacity:1;margin:0}.header-creative .vc_row[data-vc-full-width]{padding-left:50px}.header-creative.header-open .vc_row[data-vc-full-width]{padding-left:250px}.header-open .vc_parallax .vc_parallax-inner{left:auto;width:calc(100% - 250px)}.header-open.header-rtl .vc_parallax .vc_parallax-inner{left:0;right:auto}#Header_creative.scroll{height:100%;overflow-y:auto}#Header_creative.scroll:not(.dropdown) .menu li ul{display:none!important}#Header_creative.scroll #Action_bar{position:static}#Header_creative.dropdown{outline:none}#Header_creative.dropdown #Top_bar .menu_wrapper{float:left;width:100%}#Header_creative.dropdown #Top_bar #menu ul li{position:relative;float:left}#Header_creative.dropdown #Top_bar #menu ul li a:not(.menu-toggle):after{display:none}#Header_creative.dropdown #Top_bar #menu ul li a span{line-height:38px;padding:0}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:38px;height:38px;line-height:38px;font-size:26px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33;z-index:203}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+";position:static}#Header_creative.dropdown #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}#Header_creative.dropdown #Top_bar #menu ul.sub-menu li:not(:last-of-type) a{border-bottom:0}#Header_creative.dropdown #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin-left:0!important;width:auto!important;background-image:none}#Header_creative.dropdown #Top_bar #menu ul li ul li{width:100%!important}#Header_creative.dropdown #Top_bar #menu ul li ul li a{padding:0 10px;text-align:center}#Header_creative.dropdown #Top_bar #menu ul li ul li a .menu-arrow{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul li a span{padding:0}#Header_creative.dropdown #Top_bar #menu ul li ul li a span:after{display:none!important}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}#Header_creative.dropdown #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}#Header_creative{transition:left .5s ease-in-out,right .5s ease-in-out}#Header_creative .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out .5s}#Header_creative.active .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out}}@media only screen and (min-width:1240px){#Top_bar.is-sticky{position:fixed!important;width:100%;left:0;top:-60px;height:60px;z-index:701;background:#fff;opacity:.97;-webkit-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);-moz-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);box-shadow:0 2px 5px 0 rgba(0,0,0,0.1)}.layout-boxed.header-boxed #Top_bar.is-sticky{left:50%;-webkit-transform:translateX(-50%);transform:translateX(-50%)}#Top_bar.is-sticky .top_bar_left,#Top_bar.is-sticky .top_bar_right,#Top_bar.is-sticky .top_bar_right:before{background:none;box-shadow:unset}#Top_bar.is-sticky .logo{width:auto;margin:0 30px 0 20px;padding:0}#Top_bar.is-sticky #logo,#Top_bar.is-sticky .custom-logo-link{padding:5px 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#Top_bar:not(.is-sticky){background-color:rgba(255,255,255,0.8)}}@media only screen and ( max-width:767px ){#Top_bar{background-color:#ffffff !important}#Action_bar{background-color:#007dc5 !important}#Action_bar .contact_details{color:#222222}#Action_bar .contact_details a{color:#0095eb}#Action_bar .contact_details a:hover{color:#007cc3}#Action_bar .social li a,#Action_bar .social-menu a{color:#bbbbbb!important}#Action_bar .social li a:hover,#Action_bar .social-menu a:hover{color:#777777!important}} form input.display-none{display:none!important} </style> <link rel='stylesheet' id='style-css' href='https://www.wyatt.com/wp-content/themes/betheme-child/style.css?ver=6.4.5' type='text/css' media='all' /> <style id='mfn-custom-inline-css' type='text/css'> @supports (-ms-ime-align: auto) { } span {font-family:"Open Sans", Arial, Tahoma, sans-serif !important;} @media only screen and (min-width: 1240px) { .header-classic #Header .top_bar_left {width:1306px;} #Top_bar .menu > li > a {padding:15px 5px;} #Top_bar.is-sticky .menu_wrapper .menu > li > a {padding:15px 5px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu{ padding-top:0px; padding-bottom:0px; width:92.5%!important; margin:0px 3%;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu .container {display:block;} /** Added 121024 **/ h1 { line-height: 44px !important; } .h2-underline {border-bottom: thick solid #ffb600; padding-bottom: 15px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu::before {content:' '; background:#fff; position:absolute; width:100vw; height:100%; margin-left: -50vw; left: 50%; } .mm-vertical #Top_bar .menu > li > .menu-overlap {z-index:1;background:rgba(0,0,0,0.4); position:absolute; width:100vw; height:100vh; margin-left: -50vw; left: 50%; cursor:hand; cursor:pointer;} .mm-vertical #Top_bar .menu > li.not-active a{color:#444444;} .mm-vertical #Top_bar .menu > li.not-active a::after {opacity:0;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title, .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title:hover {padding:5px 0px; background:transparent; color:#444444; text-transform:unset;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title:hover span {text-decoration:none ;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu ul {background:transparent; } .mm-vertical #Top_bar .menu > li >ul.mfn-megamenu ul a {color:#007dc5; } .mm-vertical #Top_bar .menu > li >ul.mfn-megamenu ul a:hover {background:transparent;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a {padding:5px 0px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a:hover {text-decoration:underline;} .mm-vertical #Top_bar .menu > li > ul {padding:20px 20px 20px 2px;} .mm-vertical #Top_bar .menu > li > ul a {padding:5px; border:0px; color:#007dc5;} .mm-vertical #Top_bar .menu > li > ul a:hover {background:transparent; } .mm-vertical #Top_bar .menu > li > ul a:hover span {text-decoration:underline ;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li {padding-top:20px; padding-bottom:25px; border-right: 0px solid rgba(0, 0, 0, 0.05);} /*for parent title in sbmenu*/ .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child {display:none; width:auto; padding-bottom:0px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child h3 {padding-top:20px; line-height:30px; border-bottom:1px solid #ccc; font-weight:600;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child h3 a{color:#444444;} /*for contact submenu*/ .mm-vertical #Top_bar .menu > li#menu-item-2437 li.mfn-megamenu-cols-2 li {} /*menu button css*/ .mm-vertical #Top_bar .menu > li#menu-item-5221 a span {background:#007dc5; color:#fff; border-radius:6px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-5221 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-5221 > a, #Top_bar.is-sticky .menu > li#menu-item-5221 > a span {line-height:30px; margin-top:0px;} .mm-vertical #Top_bar li#menu-item-6152 a {color:#000 !important; padding-top:0px !important; white-space:nowrap; color: #007dc5 !important; font-weight: 400;} /*set width of menu item*/ .mm-vertical #Top_bar li#menu-item-2341 {width:343px; padding-left: 80px;} .mm-vertical #Top_bar li#menu-item-2348 {width:278px;} .mm-vertical #Top_bar li#menu-item-2355 {width:288px;} .mm-vertical #Top_bar li#menu-item-2363 {width:240px;} .mm-vertical #Top_bar li#menu-item-2369 {width:541px; padding-left:70px;} .mm-vertical #Top_bar li#menu-item-2379 {width:340px;} .mm-vertical #Top_bar li#menu-item-2384 {width:280px;} .mm-vertical #Top_bar li#menu-item-2391 {width:350px; padding-left:80px;} .mm-vertical #Top_bar li#menu-item-2395 {width:310px;} .mm-vertical #Top_bar li#menu-item-2403 {width:310px;} .mm-vertical #Top_bar li#menu-item-2408 {width:210px;} .mm-vertical #Top_bar li#menu-item-5918 {width:487px; padding-left:115px;} .mm-vertical #Top_bar li#menu-item-5919 {width:387px;} .mm-vertical #Top_bar li#menu-item-5920 {width:280px;} .mm-vertical #Top_bar li#menu-item-2427 {width:700px; padding-left:300px;} .mm-vertical #Top_bar li#menu-item-5235 {width:487px; padding-left:115px;} .mm-vertical #Top_bar li#menu-item-5765 {width:310px;} .mm-vertical #Top_bar li#menu-item-26131 {width:387px;} .mm-vertical #Top_bar li#menu-item-15082 {width:700px; padding-left:300px;} .mm-vertical #Top_bar li#menu-item-15044 {width:397px;} } @media only screen and (max-width: 1239px) { #menu > ul > li > a, a.action_button, #overlay-menu ul li a { font-size: 15px; font-weight: 400; letter-spacing: 1px;} .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child {display:none; width:auto; padding-bottom:0px;} .mm-vertical #Top_bar #menu ul li ul li a {font-size:16px;} .mm-vertical #Top_bar #menu ul li ul li ul li a {font-size:15px;} } /* Header */ .header-classic #Top_bar { border-bottom: 0px solid #e1e1e1;} .header-classic:not(.home) #Content { border-top: 0px solid #e1e1e1; } .header-classic.home .mfn-rev-slider { border-top: 1px solid #e1e1e1; } /*Action Bar*/ #Action_bar a {color:#fff;} /* Widget */ .widget-area:before { display: none; } .aside_left .widget-area { border: 0; } /* Icon box */ .icon_box.has_border { background: #fff; border: 1px solid #e1e1e1; padding: 40px 10%; } .icon_box.no_border {background: #fff; border:0px; padding: 40px 10%;} .icon_box.has_border:after {border:0px} /* Offer box */ .offer_box { background-color: #252525; padding: 20px 20px 5px; text-align: center; } .offer_box .offer_box_list { border-width: 1px 1px 0 1px; border-style: solid; border-color: #929292; font-weight: 700; font-size: 16px; letter-spacing: 2px; margin-bottom: 20px; } .offer_box .offer_box_list a { display: block; color: #fff; border-bottom: 1px solid #929292; padding: 18px 15px; word-wrap: break-word; } /* Footer */ /*#Footer { border-top: 1px solid #e1e1e1; }*/ #Footer .widget > h4 { font-size: 18px; font-weight: 300; margin-bottom: 20px; } #Footer .footer_copy { background: #465158; border-top: 0; } .before-footer {background: #f9f9f9;} #Footer .footer_copy .social { display: none; } /**/ .top-widgets-container {float:right} .top-widgets-container .widget {padding-bottom:0px; margin-bottom:0px; float:right;margin-top:0px;} .top-widgets-container .widget ul.menu{list-style:none; padding:0px;} .top-widgets-container .widget ul.menu li {float:left; padding:12px 0px;} .top-widgets-container .widget ul.menu li a{padding:0px 20px; border-right:1px solid #ccc; line-height:15px;} .top-widgets-container .widget ul.menu li:last-child a{border-right:0px;} .top-widgets-container .widget_search .icon-search-fine {font-size:24px; line-height:40px;} .top-widgets-container .widget_search input[type="text"] {width:82%; float:right; padding:5px 10px 5px 5px; border:0px; margin-top:7px; height:30px;min-height:30px;} #menu-top-navigation .cart a {padding:0px 20px; } #menu-top-navigation .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:10px; font-size:26px; color:#fff; text-indent:0;} .mobilecart {display:none; width:30px; float:right; margin-top:11px;} .mobilecart a { padding:0px; border:0px;} .mobilecart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; left:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { .top-widgets-container .widget {float:none;} .top-widgets-container .widget.widget_nav_menu {max-width:245px; margin:0px auto; clear:both;} .top-widgets-container .widget ul.menu li a {padding:0px 15px;} #menu-top-navigation .cart.menu-item-2449 {display:none;} #menu-top-navigation .cart a {padding:0px 10px;} .widget_archive ul li:after, .widget_nav_menu ul li:after {display:none;} .widget:after {display:none;} .top-widgets-container {float:none; margin:0px auto;} .top-widgets-container .widget_search input[type="text"] {width:80%;} .mobilecart {display:block;} .top-widgets-container .widget_search {width:254px; overflow:hidden;padding-bottom:20px; margin:0px auto;} .top-widgets-container .widget_search .searchform{width:210px; float:left;} } .icon-100 .image_wrapper img {width:150px; height:150px;} .down-heading, .heading {padding-left:17px;} @media only screen and (min-width:320px) and (max-width:767px) { .down-heading, .heading {padding:0px; text-align:center;} } .ui-tabs .ui-tabs-nav li {border-width:0px;} .page-id-2602 .ui-tabs .ui-tabs-nav li a {padding:14px 28px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li {border:0px; padding:5px 0px;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {background-image:none; font-size:100%; color:#2991d6; padding:5px 10px 5px 20px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a:hover {text-decoration:underline;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a {color:#000; border-left:3px solid #2991d6; border-radius:0px !important; padding:5px 10px 5px 17px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav {width:23%; border:0px !important;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-panel {width:76.7%; border:0px !important; padding-top:5px;} @media only screen and (min-width:768px) and (max-width:1239px) { .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {font-size:100%;} } @media only screen and (min-width:320px) and (max-width:767px) { .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav {width:100%;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-panel {width:100%; padding-top:15px;} .column_tabs .tabs_vertical.ui-tabs .ui-tabs-nav li a {-webkit-box-shadow:none;-moz-box-shadow:none;box-shadow:none;} } .ui-tabs .ui-tabs-nav li h3 {margin:0px; padding:0px;} .ui-tabs .ui-tabs-nav li h3 a { text-decoration: none; display: block; padding: 14px 30px !important; font-size: 100%; font-weight:initial; } .ui-tabs .ui-tabs-panel .icon_box {padding-bottom:2px;} .ui-tabs .ui-tabs-panel .column.one-fourth {width:25%;} .ui-tabs .ui-tabs-panel .column.one-second, .ui-tabs .ui-tabs-panel .column.one-fourth, .ui-tabs .ui-tabs-panel .column.one-third, .ui-tabs .ui-tabs-panel .column.two-third{margin-left:0px; margin-right:0px;} @media only screen and (min-width: 960px) and (max-width: 1239px) { .ui-tabs .ui-tabs-nav li h3 a {font-size:100%; padding:10px 20px !important;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .ui-tabs .ui-tabs-nav li h3 a {font-size:100%; padding:5px 10px !important;} } /* Make Nav Subheadings unclickable */ .unclickable > a:hover { cursor: default;} .wp-caption-text { background: transparent; color: #075c97; font-size:90%;} .ls-wrapper h3 a {color: #075c97;} .column_sidebar_widget {float:none;} /*app notes*/ ul.clients.appnotes .client_wrapper {text-align:left; height:auto !important; line-height:auto !important; overflow:hidden;} ul.clients.appnotes li:nth-child(2n+1) {clear:both;} ul.clients.appnotes .client_wrapper img { position:relative; left:auto !important; top: auto !important; float:left; -webkit-transform: none!important; -moz-transform: none!important; transform: none!important; padding-right:20px; width:auto!important; } ul.clients.appnotes .client_wrapper h3 { line-height:20px; font-size:16px; letter-spacing:1px; padding-top:10px;} ul.clients.appnotes .client_wrapper a:hover {text-decoration:none;} @media only screen and (max-width: 640px) { ul.clients.appnotes li {width:100% !important; clear:both;} } .pager {padding-top:20px;} .pager .page-numbers {border:1px solid #ccc; padding:3px 5px;} .pager .prev.page-numbers, .pager .next.page-numbers {border:0px;} .alignleft {margin:3px 10px 10px 0px;} dl {clear:both;} .team.team_vertical img.scale-with-grid {width:100%;} .column_placeholder {margin-bottom:0px;} .icon-height img{max-height:50px;} .single .post-header {margin-left:0px; margin-right:0px;} .single .section-post-header .single-photo-wrapper.image {display:none;} .widget_mfn_menu ul li.menu-item-has-children > a::after {content: '\e868'; font-family: "mfn-icons"; right:2px; position:absolute; width:20px; height:15px; color:#ccc; } table th ul, table td ul {list-style-position:inside !important;} .sticky-white #Top_bar.is-sticky, .sticky-white #Top_bar.is-sticky #menu, #Top_bar.is-sticky {background:#fff; opacity:1;} /*Webinars latest posts*/ .parent-pageid-3663 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .parent-pageid-3663 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .parent-pageid-3663 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .parent-pageid-3663 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .parent-pageid-3663 .Latest_news ul li.category-webinars .desc h5 a{color:#007dc5;} .parent-pageid-3663 .Latest_news ul li .desc_footer .date {display:none;} .parent-pageid-3663 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .parent-pageid-3663 .Latest_news ul li .desc_footer .post-comments {display:none;} .parent-pageid-3663 .Latest_news ul li .desc_footer .button-love {display:none;} .parent-pageid-3663 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .parent-pageid-3663 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Upcoming Live Webinars*/ .page-id-2653 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-2653 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-2653 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-2653 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-2653 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-2653 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-2653 .Latest_news ul li.category-webinars .desc h5 a{color:#007dc5;} .page-id-2653 .Latest_news ul li .desc_footer .date {display:none;} .page-id-2653 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-2653 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-2653 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-2653 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-2653 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Newsletter Archive*/ .page-id-3661 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-3661 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-3661 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-3661 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-3661 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-3661 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-3661 .Latest_news ul li.category-newsletter-archive .desc h5 a{color:#007dc5;} .page-id-3661 .Latest_news ul li .desc_footer .date {display:none;} .page-id-3661 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-3661 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-3661 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-3661 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-3661 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Ask the Expert*/ .page-id-5348 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-5348 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-5348 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-5348 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-5348 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-5348 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-5348 .Latest_news ul li .desc h5{margin-bottom:0px;} .page-id-5348 .Latest_news ul li.category-ask-the-expert .desc h5 a{color:#007dc5;} .page-id-5348 .Latest_news ul li .desc_footer {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .date {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-5348 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-5348 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-5348 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-5348 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; font-weight:normal; line-height:20px;} /*accordion title as h3*/ .accordion .question .title h3 {margin-bottom:0px; } .accordion .question.active .title h3{color:#2991d6} /*column padding*/ .column, .columns {margin:0px 10px 40px;} .accordion .answer .one-second.column {width:47%;} .wrap .one-second.column {width:47%;} /*.column_column ul li {margin-bottom:2px;}*/ .single .post-header {margin-bottom:10px;} /* Appnote seach box*/ .widget_appnote_search_widget {clear:both; display:block; overflow:hidden;} .widget_appnote_search_widget .widget-title {display:inline-block; float:left; margin-right:15px; margin-top:5px;} .widget_appnote_search_widget .searchform {display:inline-block; float:left;} .widget_appnote_search_widget .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .widget_appnote_search_widget .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .widget_appnote_search_widget .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .widget_appnote_search_widget .searchform input[type=submit] {margin:0px; margin-top:15px;} } /*flat box*/ .flat_box .photo_wrapper .icon {display:none;} .flat_box .photo_wrapper img.photo {transform: translateX(0px)} .flat_box .desc_wrapper {margin-left:0px;} /*center images at user profile*/ .page-id-2504 .image_frame .image_wrapper {text-align:center} .page-id-2504.if-overlay .image_frame:hover .image_wrapper img, .page-id-2504.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .if-overlay .image_frame .image_wrapper .image_links {display:none;} /* Changes for ClickDimensions submit button */ a.button_theme, a.tp-button.button_theme, button, input[type="submit"], input[type="reset"], input[type="button"] { background-color: #0065a4 !important; color: #ffffff !important; font-family: inherit !important; /*padding:0px;*/ } /*isotope wrapper*/ .blog_wrapper.isotope_wrapper .post-item .post-footer {background:none;} .blog_wrapper.isotope_wrapper .post-item .post-footer .post-links{border:0px;} .blog_wrapper.isotope_wrapper .grid .post-photo-wrapper {border:0px;} /* product page*/ .page-id-2582 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-2582 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-2582.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-2582.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-2582 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-2582 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-2582 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-2582 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-2582 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } .uk-margin-small-right {vertical-align:middle; margin-top:-2px;} .page-id-2647 .ui-tabs .ui-tabs-panel .column.one-second {margin-bottom:0px;} .page-id-3641 .blog_wrapper .classic .post-photo-wrapper {border-color:transparent;} @media only screen and (min-width: 960px) { .page-id-3641 .blog_wrapper .classic .post-photo-wrapper {width:12%;} .page-id-3641 .blog_wrapper .classic .post-desc-wrapper {width:88%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-3641 .blog_wrapper .classic .post-photo-wrapper { width:25%} .page-id-3641 .blog_wrapper .classic .post-desc-wrapper {width:75%;} } @media only screen and (min-width: 768px) { .page-id-2640 .column.column_pricing_item {margin:0px 1% 40px;} } /* contact form 7 submit button*/ .wpcf7-form-control.wpcf7-submit {padding:10px 30px;} .wpcf7 .red {color:#990000;} .wpcf7 span.wpcf7-list-item {display:block; margin:0px;} .wpcf7 label {font-weight:400;} #lostusername {border:1px solid #ddd; padding:30px 20px 0px;} #lostusername .input {width:100%;} #lostusername .button {padding:10px 20px;} .ur-frontend-form button[type="submit"], .ur-frontend-form input[type="submit"] {float:none;} .page-id-2690.if-overlay .image_frame:hover .image_wrapper img, .page-id-2690.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .page-id-2690 .team .desc_wrapper hr {display:none;} .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-second, .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-fourth, .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-third, .page-id-2690 .ui-tabs .ui-tabs-panel .column.two-third {margin-left:10px; margin-right:10px;} .page-id-2690 .ui-tabs .ui-tabs-panel .column.one-fourth {width:23.4%;} /* webinars seach box*/ .widget_webinars_search_widget {clear:both; display:block; overflow:hidden;} .widget_webinars_search_widget .widget-title {display:inline-block; float:left; margin-right:15px; margin-top:5px;} .widget_webinars_search_widget .searchform {display:inline-block; float:left;} .widget_webinars_search_widget .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .widget_webinars_search_widget .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .widget_webinars_search_widget .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .widget_webinars_search_widget .searchform input[type=submit] {margin:0px; margin-top:15px;} } /*Recent Webinars nav issue fix*/ .page-id-3665 li#menu-item-2421.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-3665 li#menu-item-2421.current-menu-ancestor:not(.hover) a:after {display:none;} /*login-in nav issue fix*/ .page-id-5451 li#menu-item-2390.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-5451 li#menu-item-2390.current-menu-ancestor:not(.hover) a:after {display:none;} /* Contact Customer Support nav issue fix*/ .page-id-9343 li#menu-item-2390.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-9343 li#menu-item-2390.current-menu-ancestor:not(.hover) a:after {display:none;} /* custom seach box*/ .search #Content .searchform {display:inline-block; float:left;} .search #Content .searchform h4{clear:both; padding:10px 0px; margin:0px;} .search #Content .searchform input[type=text] {float:left; margin:0px; min-width:350px; padding:7px 10px;} .search #Content .searchform select {-webkit-appearance:menulist; padding:7px 10px;} .search #Content .searchform input[type=submit] {background:#0065a4; margin:0px; margin-left:15px; padding:8px 20px;} @media only screen and (min-width: 320px) and (max-width: 650px) { .search #Content .searchform input[type=text] {min-width:240px;} } @media only screen and (min-width: 320px) and (max-width: 519px) { .search #Content .searchform input[type=submit] {margin:0px; margin-top:15px;} } .wpcf7-form .anr_captcha_field {position:absolute;} /*newsletter archive tables remove border*/ .post.category-newsletter-archive .post-wrapper-content table td {box-shadow:none; border:0px;} .be-ix-link-block {max-width:750px; text-align:center; margin:0px auto; padding-top:20px;} #Footer .widgets_wrapper .column {margin:0px 9px 0px;} @media only screen and (min-width: 768px) and (max-width: 959px) { #Footer .widgets_wrapper .column {margin:0px 5px 0px;} } /*Login page popup */ .page-id-5451.logged-in #pum-8728 {display:none !important;} #cookie-law-info-bar a {color:#fff; text-decoration:underline;} #cookie-law-info-bar a:hover {text-decoration:none;} #cookie-law-info-bar .cli-plugin-button {text-decoration:none;} @media only screen and (min-width: 320px) and (max-width: 767px) { #cookie-law-info-again{display:none !important;} } /*After Multi Language SETUP*/ #Action_bar .column {overflow:visible;} .top-widgets-container .widget_search input[type="text"] {margin-top:5px;} .widget.widget_nav_menu::after, .widget.widget_icl_lang_sel_widget::after, .widget_archive ul li:after, .widget_nav_menu ul li:after {display:none;} .wpml-ls-legacy-dropdown-click {margin-top:6px; } .wpml-ls-legacy-dropdown-click a, .wpml-ls-legacy-dropdown-click a:hover, .wpml-ls-legacy-dropdown-click a:focus, .wpml-ls-legacy-dropdown-click .wpml-ls-current-language:hover>a {color:#626262 !important; border:0px;text-decoration:none;} .wpml-ls-legacy-dropdown-click .wpml-ls-sub-menu {z-index:999;} .top-widgets-container h2.title {display:none;} @media only screen and (min-width: 320px) and (max-width: 767px) { .wpml-ls-legacy-dropdown-click {margin:6px auto 0px; } .top-widgets-container .widget_search {clear:both;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .wpml-ls-legacy-dropdown-click {width:auto;} } #menu-top-navigation-ch .cart a {padding:0px 20px; } #menu-top-navigation-ch .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:10px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-ch .cart.menu-item-2449 {display:none;} #menu-top-navigation-ch .cart a {padding:0px 10px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-13087 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-13087 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-13087 > a, #Top_bar.is-sticky .menu > li#menu-item-13087 > a span {line-height:30px; margin-top:0px;} } .post-9911 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .post-9911 span.wpcf7-form-control-wrap{margin-bottom:20px;} .post-9911 .wpcf7-list-item-label{color:#000000;} .post-9911 .unique .one-third.column{width:30.333% !important;} .post-9911 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .post-9911 .wrap .one-second.column{width:32%;} .post-9911 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .post-9911 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .post-9911 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .post-9911 .wpcf7 span.wpcf7-list-item{width: 100%;} .post-9911 .unique .one-third.column{width:100% !important;} .post-9911 .wrap .one-second.column{width:100%;} .post-9911 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*remove meta from search-results*/ .search.search-results .post-item .post-meta {display:none;} .search.search-results .post-item .post-desc {padding-left:0px;} /*footer update*/ /*#Footer .widgets_wrapper {padding-bottom:10px;} #Footer .widgets_wrapper .column {margin-bottom:10px;} #Footer #custom_html-4 > h4 {text-align:center;} #Footer #custom_html-14 > h4 {text-align:center;} #Footer #custom_html-9 {max-width:160px; margin:0px auto; clear:both; padding-top:25px;} .footer-resources {max-width:80%; margin:0px auto; } .footer-resources li {float:left; line-height:28px;} .footer-resources li:nth-child(1), .footer-resources li:nth-child(6){width:12%; clear:both;} .footer-resources li:nth-child(2), .footer-resources li:nth-child(7){width:28%;} html[lang="zh-hans"] .footer-resources li:nth-child(1), html[lang="zh-hans"] .footer-resources li:nth-child(6){width:15%; clear:both;} html[lang="zh-hans"] .footer-resources li:nth-child(2), html[lang="zh-hans"] .footer-resources li:nth-child(7){width:25%;} .footer-resources li:nth-child(3), .footer-resources li:nth-child(8){width:17%;} .footer-resources li:nth-child(4), .footer-resources li:nth-child(9){width:18%;} .footer-resources li:nth-child(5), .footer-resources li:nth-child(10){width:25%;} @media only screen and (min-width:320px) and (max-width:1239px) { .footer-resources {max-width:60%; } .footer-resources li:nth-child(1), .footer-resources li:nth-child(6){width:50%; clear:none;} .footer-resources li:nth-child(2), .footer-resources li:nth-child(7){width:50%;} .footer-resources li:nth-child(3), .footer-resources li:nth-child(8){width:50%;} .footer-resources li:nth-child(4), .footer-resources li:nth-child(9){width:50%;} .footer-resources li:nth-child(5), .footer-resources li:nth-child(10){width:50%;} } @media only screen and (min-width:320px) and (max-width:767px) { .footer-resources {max-width:100%; } #Footer #custom_html-4 > h4 {text-align:left;} #Footer #custom_html-14 > h4 {text-align:left;} #Footer #custom_html-9 {max-width:100%;} } */ .tabs_vertical.ui-tabs .ui-tabs-nav li a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li a.button:hover, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button:hover { background: #007dc5; color: #fff; border-radius: 10px !important; text-align: center; margin-left: 20px; margin-top: 20px; display:inline-block; text-decoration: none; padding: 0px 20px !important; border:0px; text-transform: uppercase; line-height:30px; font-size: 15px; font-weight: 400;letter-spacing: 1px;} @media only screen and (min-width:320px) and (max-width:767px) { .tabs_vertical.ui-tabs .ui-tabs-nav li h3, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active h3 {text-align:center;} .tabs_vertical.ui-tabs .ui-tabs-nav li a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li a.button:hover, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button:hover {margin:20px auto;} } /*Webinars latest posts zh-hans*/ .parent-pageid-11725 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .parent-pageid-11725 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .parent-pageid-11725 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .parent-pageid-11725 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .parent-pageid-11725 .Latest_news ul li.category-webinars-zh-hans .desc h5 a{color:#007dc5;} .parent-pageid-11725 .Latest_news ul li .desc_footer .date {display:none;} .parent-pageid-11725 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .parent-pageid-11725 .Latest_news ul li .desc_footer .post-comments {display:none;} .parent-pageid-11725 .Latest_news ul li .desc_footer .button-love {display:none;} .parent-pageid-11725 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .parent-pageid-11725 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Upcoming Live Webinars zh-hans*/ .page-id-11764 .Latest_news ul li {margin-top:15px; margin-bottom:15px;} .page-id-11764 .Latest_news ul li.has-post-thumbnail .desc {margin-left: 70px; width: 95%;} .page-id-11764 .Latest_news ul li .photo {width:70px; border-right:0px; text-align:center; display:table;} .page-id-11764 .Latest_news ul li .photo a {display:table-cell; vertical-align:middle;} .page-id-11764 .Latest_news ul li .photo img {max-width:50px !important; vertical-align:middle;} .page-id-11764 .Latest_news ul li .desc {border-left:3px solid #000; padding-top:0px; padding-bottom:0px; display:table-cell; vertical-align:middle;} .page-id-11764 .Latest_news ul li.category-webinars-zh-hans .desc h5 a{color:#007dc5;} .page-id-11764 .Latest_news ul li .desc_footer .date {display:none;} .page-id-11764 .Latest_news ul li .desc_footer .icon-comment-empty-fa {display:none} .page-id-11764 .Latest_news ul li .desc_footer .post-comments {display:none;} .page-id-11764 .Latest_news ul li .desc_footer .button-love {display:none;} .page-id-11764 .Latest_news ul li .desc .post-excerpt {margin-top:0px;} .page-id-11764 .Latest_news ul li .desc .post-excerpt p{margin-bottom:0px; line-height:20px;} /*Request Product Quote zh-hans*/ .page-id-12227 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .page-id-12227 span.wpcf7-form-control-wrap{margin-bottom:20px;} .page-id-12227 .wpcf7-list-item-label{color:#000000;} .page-id-12227 .unique .one-third.column{width:29% !important;} .page-id-12227 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .page-id-12227 .wrap .one-second.column{width:32%;} .page-id-12227 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12227 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12227 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .page-id-12227 .wpcf7 span.wpcf7-list-item{width: 100%;} .page-id-12227 .unique .one-third.column{width:100% !important;} .page-id-12227 .wrap .one-second.column{width:100%;} .page-id-12227 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*Request Product Info zh-hans*/ .page-id-12612 .wpcf7 span.wpcf7-list-item{width: 260px;display: inline-block;} .page-id-12612 span.wpcf7-form-control-wrap{margin-bottom:20px;} .page-id-12612 .wpcf7-list-item-label{color:#000000;} .page-id-12612 .unique .one-third.column{width:29% !important;} .page-id-12612 .unique .required{color: #ff0000; font-size: 13px; padding: 0 5px 0 5px;} .page-id-12612 .wrap .one-second.column{width:32%;} .page-id-12612 .wpcf7 hr.small {color:#000000;background-color:#000000;height:1px; max-width: 440px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12612 .wpcf7 hr.large{color:#000000;background-color:#000000;height:1px; max-width: 760px;margin-bottom: 15px;margin-left:0px;margin-top:25px;} .page-id-12612 .wpcf7 p strong{font-weight:normal; font-size:18px; color:#1F497D;} @media only screen and (min-width: 320px) and (max-width: 959px) { .page-id-12612 .wpcf7 span.wpcf7-list-item{width: 100%;} .page-id-12612 .unique .one-third.column{width:100% !important;} .page-id-12612 .wrap .one-second.column{width:100%;} .page-id-12612 span.wpcf7-form-control-wrap {margin-bottom:0px;} } /*Team in zh-hans*/ .page-id-12002.if-overlay .image_frame:hover .image_wrapper img, .page-id-12002.if-overlay .image_frame.hover .image_wrapper img {transform: scale(1);} .page-id-12002 .team .desc_wrapper hr {display:none;} .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-second, .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-fourth, .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-third, .page-id-12002 .ui-tabs .ui-tabs-panel .column.two-third {margin-left:10px; margin-right:10px;} .page-id-12002 .ui-tabs .ui-tabs-panel .column.one-fourth {width:23.4%;} /* product page in zh-hans*/ .page-id-12156 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-12156 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-12156.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-12156.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-12156 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-12156 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-12156 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-12156 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-12156 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } /*Recent Webinars nav issue fix for zh-hans*/ .page-id-11728 li#menu-item-13052.current-menu-ancestor:not(.hover) a {color:#000000;} .page-id-11728 li#menu-item-13052.current-menu-ancestor:not(.hover) a:after {display:none;} .large h3{font-size:22px; line-height:30px;} .small {margin-left:25px;} sup {display:inline-block; margin-top:-4px;} sub {display:inline-block; margin-bottom:-4px;} sup, sub {display:inline-table;} .ui-tabs-panel .one-second.column {width:50%;} .parent-pageid-2582 .ui-tabs-panel td {text-align:left !important;} .ls-borderlessdark3d .ls-shadow { display: none !important;} #menu-top-navigation-de .cart a {padding:0px 20px;} #menu-top-navigation-de .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-de .cart.menu-item-14543{display:none;} #menu-top-navigation-de .cart a {padding:0px 10px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-15087 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-15087 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-15087 > a, #Top_bar.is-sticky .menu > li#menu-item-15087 > a span {line-height:30px; margin-top:0px;} } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar li#menu-item-12984 a {color:#000 !important; padding-top:20px !important;} .mm-vertical #Top_bar li#menu-item-14978 a {color:#000 !important; padding-top:20px !important;} } #Footer #custom_html-15 > h4 {text-align:center;} /* product page German */ .page-id-14845 .ui-tabs-panel .team.team_vertical .image_frame {border:0px;} .page-id-14845 .ui-tabs-panel .team.team_vertical hr.hr_color {background:none;} .page-id-14845.if-overlay .ui-tabs-panel .team.team_vertical .image_frame:hover .image_wrapper img, .page-id-14295.if-overlay .ui-tabs-panel .team.team_vertical .image_frame.hover .image_wrapper img {-webkit-transform: scale(1); -moz-transform: scale(1); -o-transform: scale(1); transform: scale(1); } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-3) {margin-left:10px; margin-right:17px; } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-2) {margin-left:18px; margin-right:17px; } .page-id-14845 .ui-tabs-panel .one-third.column:nth-child(4n-1) {margin-left:18px; margin-right:10px; } .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:65px; margin-right:52px; } .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(even) {margin-left:53px; margin-right:65px; } @media only screen and (min-width: 1301px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:30.9%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:40.2%;} } @media only screen and (min-width: 1240px) and (max-width: 1300px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:30.7%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:47.6%;} } @media only screen and (min-width: 960px) and (max-width: 1239px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:29.9%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:36.6%;} } @media only screen and (min-width: 768px) and (max-width: 959px) { .page-id-14845 .ui-tabs-panel .one-third.column {width:28.7%;} .page-id-14845 .ui-tabs-panel .one-second.column {width:38.9%;} } @media only screen and (min-width: 320px) and (max-width: 767px) { .page-id-14845 .ui-tabs-panel .one-third.column {margin-left:0px; margin-right:0px;} .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(even), .page-id-14845 .ui-tabs-panel .one-second.column:nth-child(odd) {margin-left:0px; margin-right:0px;} } .parent-pageid-14845 .ui-tabs-panel td {text-align:left !important;} .button_align.align_left .button {text-align:left; padding:10px 0;} .button_align.align_left .as_tab {font-size: 18px; line-height: 20px; font-weight: 400; background:#fff; letter-spacing: 0px; color: #2991d6 !important; padding: 5px 10px 5px 20px;margin:0; } .button_align.align_left .button.as_tab:hover {text-decoration:underline !important; background-color:#fff!important;} .button_align.align_left .button.as_tab:after {display:none;} .button_align.align_left .button.as_tab.active {color: #000; border-left: 3px solid #2991d6; border-radius: 0px !important; padding: 5px 10px 5px 17px !important;} .button_align.align_left .button.as_tab .button_label {margin:0!important;} .button_align.align_left .button.as_tab_btn { background: #007dc5; color: #fff; border-radius: 10px !important; text-align: center; margin-left: 20px; margin-top: 20px; display: inline-block; text-decoration: none; padding: 0px 20px !important; border: 0px; text-transform: uppercase; line-height: 30px; font-size: 15px; font-weight: 400; letter-spacing: 1px; } /*Japan language*/ #Footer #custom_html-22 > h4 { text-align: center; } #menu-top-navigation-ja .cart a {padding:0px 20px;} #menu-top-navigation-ja .cart a:before {font-family: "mfn-icons"; content:'\e82d'; float:left; padding-right:15px; font-size:26px; color:#fff; text-indent:0;} @media only screen and (min-width:320px) and (max-width:767px) { #menu-top-navigation-ja .cart.menu-item-2449 {display:none;} #menu-top-navigation-ja .cart a {padding:0px 10px;} } .mm-vertical #Top_bar .menu > li#menu-item-18403 a span {background:#007dc5; color:#fff; border-radius:10px; line-height:40px; margin-top:8px; margin-left:20px;} .mm-vertical #Top_bar .menu > li#menu-item-18403 a:after {display:none;} #Top_bar.is-sticky .menu > li#menu-item-18403 > a, #Top_bar.is-sticky .menu > li#menu-item-18403 > a span {line-height:30px; margin-top:0px;} @media only screen and (min-width: 1240px) { #Top_bar #menu-german-main-menu > li > a span:not(.description) { padding: 0 3px; font-size:14px; } } body, ul.timeline_items, .icon_box a .desc, .icon_box a:hover .desc, .feature_list ul li a, .list_item a, .list_item a:hover, .widget_recent_entries ul li a, .flat_box a, .flat_box a:hover, .story_box .desc, .content_slider.carousel ul li a .title, .content_slider.flat.description ul li .desc, .content_slider.flat.description ul li a .desc, .post-nav.minimal a i { color: #333333 !important; } .column_column ul, .column_column ol, .the_content_wrapper:not(.is-elementor) ul, .the_content_wrapper:not(.is-elementor) ol { color: #333333 !important; } .hero { margin-top: 20px; } .bg-hero { background: radial-gradient(circle at 100% 0,#ebf1f2 0% 30%,#0e81a7 100%); } .hero-full { min-height: 450px; background-color: rgba(0, 0, 0, 0.5); } .column, .columns { margin: 0px 8px 40px; } .image-container { position: relative; display: inline-block; /* oder 'block' je nach Layout */ } .ribbon { position: absolute; top: 10px; /* Abstand von oben */ left: -20px; /* Verschiebung nach links, um das Ribbon schräg zu positionieren */ background-color: #FF5733; /* Farbe des Ribbons */ color: white; /* Textfarbe */ padding: 5px 15px; /* Innenabstand */ transform: rotate(-0deg); /* Dreht das Ribbon */ transform-origin: 0 0; /* Setzt den Drehpunkt */ font-size: 14px; /* Schriftgröße */ box-shadow: 2px 2px 5px rgba(0,0,0,0.3); /* Schatten für 3D-Effekt */ z-index: 10; /* Stellt sicher, dass das Ribbon über dem Bild liegt */ } .event-badge { position: relative; margin-right: 10px; border-radius: 6px; top: 0px; /* Abstand von oben */ left: 0px; /* Verschiebung nach links, um das Ribbon schräg zu positionieren */ background-color: #007dc5; /* Farbe des Ribbons */ color: white; /* Textfarbe */ padding: 2px 8px; /* Innenabstand */ font-size: 10px; /* Schriftgröße */ box-shadow: 1px 1px 2px rgba(0,0,0,0.3); /* Schatten für 3D-Effekt */ z-index: 10; /* Stellt sicher, dass das Ribbon über dem Bild liegt */ } .btn-default { background: #007dc5; color: #fff; border-radius: 6px; line-height: 40px; margin-top: 8px; margin-left: 20px; padding: 0px 10px; } .wpcf7 form.sent .wpcf7-response-output { color: #ffffff; background-color: #46b450; } .jumpto { padding-top: 100px; /* Adjust this value to match your header's height */ margin-top: -100px; /* This should be the same value as padding-top but negative */ } .post-item { margin-bottom: 40px; position: relative; float: left; width: 100%; border: 1px solid #ccc; padding: 20px; background-color: #f8f8f8; } .post-links { background-color: #007dc5; border: 1px solid #ccc; padding: 5px 20px; } #field_1_18, #field_1_113, #field_1_20, #field_1_21, #field_1_22, #field_1_23, #field_1_24, #field_1_25, #field_1_26, #field_1_27, #field_1_49, #field_1_51, #field_1_52, #field_1_53, #field_1_54, #field_1_56, #field_1_57, #field_1_58, #field_1_59, #field_1_60, #field_1_62, #field_1_63, #field_1_64, #field_1_65, #field_1_67, #field_1_68, #field_1_70, #field_1_72, #field_1_98, #field_1_99, #field_1_100, #field_1_101, #field_1_102, #field_1_103, #field_1_104, #field_1_107, #field_1_108, #field_1_122, #field_1_123, #field_1_124, #field_1_125, #field_1_126, #field_1_127, #field_1_128, #field_1_136 { background-color: #E8E8E8; padding: 20px 30px; border: 1px solid #C4C4C4; border-bottom: 1px solid #C4C4C4; margin-top: -20px; } #field_1_73, #field_1_74, #field_1_75, #field_1_76, #field_1_77, #field_1_78, #field_1_82, #field_1_83, #field_1_84, #field_1_85, #field_1_86, #field_1_92, #field_1_93, #field_1_94, #field_1_95, #field_1_129, #field_1_132, #field_1_133, #field_1_134, #field_1_135 { background-color: #F8F8F8; padding: 20px 50px; border-bottom: 1px solid #C4C4C4; border-right: 1px solid #C4C4C4; border-left: 1px solid #C4C4C4; margin-top: -40px; } #field_1_114, #field_1_115, #field_1_116, #field_1_117, #field_1_118, #field_1_119, #field_1_120, #field_1_121, #field_1_130 { background-color: #8ed1fc; padding: 20px 50px; border-bottom: 1px solid #C4C4C4; border-right: 1px solid #C4C4C4; border-left: 1px solid #C4C4C4; margin-top: -40px; } .gfield_label { font-weight: 800 !important; font-size: 16px !important; } .post-more, .post-more:hover, .icon-doc-text { color: #ffffff; } .icon_box.has_border { background: #fff; border: 0px solid #e1e1e1 !important; padding: 40px 10%; padding-bottom: 40px; } #Footer .widget > h4 { font-size: 18px; font-weight: 600; margin-bottom: 20px; } /* new css */ .mcb-column-inner { margin: 0px; overflow:visible;} .one-sixth.column { width: 14.666%; } /* 1/6 */ .one-fifth.column { width: 18%; } /* 1/5 */ .one-fourth.column, .four.columns { width: 23%; } /* 1/4 */ .one-third.column { width: 31.333%; } /* 1/3 */ .two-fifth.column { width: 38%; } /* 2/5 */ .one-second.column { width: 48%; } /* 1/2 */ .three-fifth.column { width: 58%; } /* 3/5 */ .two-third.column { width: 64.666%; } /* 2/3 */ .three-fourth.column { width: 73%; } /* 3/4 */ .four-fifth.column { width: 78%; } /* 4/5 */ .five-sixth.column { width: 81.333%; } /* 5/6 */ .one.column { width: 98%; } /* 1/1 */ .wpcf7-form .column { margin-bottom: 10px;} .wpcf7-form .column { padding: 0px;} .wpcf7-form .column p{ margin: 0px;} .column-margin-0px.column { margin-bottom: 0 !important;} .column-margin-10px.column { margin-bottom: 0px !important;} .column-margin-20px.column { margin-bottom: 0px !important;} .page-pager, .post-pager { margin-bottom: 0!important;} .column.column_divider { margin-bottom: 0!important; height: auto!important;} #Header .container {padding-left:0; padding-right:0;} .accordion .question > .title > .acc-icon-plus, .accordion .question.active > .title > .acc-icon-minus { display: block;} .accordion .question > .title > .acc-icon-plus, .accordion .question .title > .acc-icon-minus {left:15px; top:16px;} .mcb-wrap-inner {display:block;} @media only screen and (max-width: 767px) { .section_wrapper .mcb-wrap, .section_wrapper .column, .container .column { width:100%!important; } } @media only screen and (min-width: 768px) { .be-ix-link-block .be-related-link-container .be-label {flex:0 0 17%;} .be-ix-link-block .be-related-link-container .be-list {flex:0 0 83%;} } ul.clients.appnotes .client_wrapper a, ul.clients.appnotes .client_wrapper .gs-wrapper { justify-content:left; } /*Top bar search*/ #Action_bar #global-searchfield-container .addsearch-searchfield input[type=search].icon {margin-bottom:0px; margin-top:4px; padding:5px 5px 5px 40px!important; height:30px;} #Action_bar #global-searchfield-container .addsearch-searchfield button {display:none;} #Action_bar .adds-components {padding:0px;} /*Top Shadow */ .header-classic #Top_bar { border-bottom: 0px solid #e1e1e1; box-shadow: rgba(0, 0, 0, 0.15) 0px 1.95px 2.6px; margin-bottom: 1px; } .sticky-submenu { position: -webkit-sticky; /* Für Safari */ position: sticky; top: 80px; z-index: 9999; /*background-color: #fff;*/ padding: 10px; /*border-bottom: 1px solid #ccc;*/ text-align: center; } .sticky-submenu ul { list-style-type: none; margin: 0; padding: 0; } .sticky-submenu ul li { display: inline; margin: 0 15px; } .sticky-submenu ul li a { text-decoration: none; /*color: #000;*/ color:#fff; padding: 5px; transition: border-bottom 0.3s; } .sticky-submenu ul li a.active, .sticky-submenu ul li a:hover { /*border-bottom: 2px solid #000;*/ border-bottom: 2px solid #fff; } .page-section { padding: 50px; margin-top: 50px; } .anchor-offset { display: block; position: relative; top: -60px; /* Höhe des sticky-submenu */ } .copyright a {padding:0px 7px;} .before-footer h4 {font-size:18px;} .before-footer .button {border-radius:4px;} .footer-button { padding: 10px 5px; border-radius: 5px; text-align: center; display: inline-block; width: 180px; border:1px solid #fff !important;} #Footer .widget_nav_menu ul { list-style-type: none; padding: 0px; background: none;} #Footer .widget_nav_menu ul a{padding:0px;} #Footer .widget_nav_menu {margin:20px 0px;} #Footer .one-fifth {width:16%;} #Footer .one-fifth:first-child {width:27%;} .social .icon_bar, .social .icon_bar span {width:auto !important; height:auto!important; line-height:0px!important; background-color:transparent; border:0px !important; color:#fff; font-size:24px; -webkit-box-shadow:none;box-shadow:none;} .social a:hover.icon_bar span { -webkit-transform: translateY(0%); -moz-transform: translateY(0%); transform: translateY(0%); } /*30aug2024*/ table tr:first-child td {box-shadow:none;} .btn_radius {border-radius: 4px;} #Top_bar .menu > li > a span:not(.description) {padding:0px 3px;} @media only screen and (min-width: 1300px) { #Top_bar .menu > li > a span:not(.description) {padding:0px 10px;} #Top_bar.is-sticky .menu > li > a span {padding:0px 15px;} } /** Added 11/14/24 **/ .scroll { text-decoration: none; transition: color 0.3s ease, font-weight 0.3s ease; } .scroll.active { font-weight: bold; } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-5221 a span { background: #13b5ea !important; } } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-15087 a span { background: #13b5ea !important; } } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-13087 a span { background: #13b5ea !important; } } @media only screen and (min-width: 1240px) { .mm-vertical #Top_bar .menu > li#menu-item-18403 a span { background: #13b5ea !important; } } /** Added 11/18/24 **/ .header-section { border-bottom: 8px solid #fdbb30 !important; } .header-section .mcb-background-overlay{ } .solution-box { padding: 20px; border: 4px solid #EBEDEF; min-height: 150px; } .image_frame:hover .image_wrapper .mask { display:none; } .image_frame:hover .image_wrapper img, .image_frame:focus .image_wrapper img { top: 0 !important; -webkit-transform: scale(1) !important; -moz-transform: scale(1) !important; -o-transform: scale(1) !important; transform: scale(1) !important; -webkit-transition: none !important; transition: none !important; } .section-headline { border-bottom: thick solid #fdbb30; padding-bottom: 15px; font-size: 26px; } /** Page CTA Elements **/ .responsive-container { display: flex; flex-wrap: nowrap; border: 4px solid #EBEDEF; padding: 20px; align-items: flex-start; gap: 20px; width: 100%; } .responsive-container img { width: 100px; height: auto; flex-shrink: 0; } .responsive-container div { flex: 1; } /* Breakpoint for mobile screens */ @media (max-width: 768px) { .responsive-container { flex-wrap: wrap; } .responsive-container img { width: 100%; margin-bottom: 20px; } .responsive-container div { flex: 1 1 100%; text-align: center; } } .cta-box-btn { display: inline-block; align-items: center; padding: 6px 20px; color: white; text-decoration: none; border-radius: 5px; font-size: 14px; width: fit-content; background-color: #0065a4 !important; transition: background-color 0.3s ease, transform 0.2s ease; } .cta-box-btn:hover { background-color: #0056b3; color: white; text-decoration: none; } .cta-box-icon { margin-right: 5px; } /* Sidebar-Button-Styling */ .sidebar-btn { display: block; width: 100%; text-align: center; padding: 10px 20px; box-sizing: border-box; background-color: #13b5ea !important; font-size: 16px; color: white; border-radius: 5px; transition: background-color 0.3s ease, transform 0.2s ease; } .sidebar-btn:hover { background-color: #0065a4 !important; color: white; text-decoration: none; } /*LS nav style*/ html body .ls-bottom-nav-wrapper a, #ls-global .ls-bottom-nav-wrapper a {background-image:none; border-radius:20px; background-color:#999; margin:3px; width:15px; height:15px;} html body .ls-bottom-nav-wrapper a.v, #ls-global .ls-bottom-nav-wrapper a.ls-nav-active {background-color:#2991d6;} .tabs_vertical.ui-tabs .ui-tabs-nav li a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button, .tabs_vertical.ui-tabs .ui-tabs-nav li a.button:hover, .tabs_vertical.ui-tabs .ui-tabs-nav li.ui-tabs-active a.button:hover { background: #007dc5; color: #fff; border-radius: 8px !important; text-align: center; margin-left: 20px; margin-top: 17px; display: inline-block; text-decoration: none; padding: 5px 12px !important; border: 0px; text-transform: uppercase; line-height: 30px; font-size: 16px; font-weight: 500; letter-spacing: 1px; width: 80%; } /* Marketo Forms */ .mktoForm, .mktoForm .mktoFieldWrap, .mktoForm .mktoHtmlText, .mktoForm input, 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mcb-section-inner mcb-section-inner-512a997c2"><div class="wrap mcb-wrap mcb-wrap-5164f961f one tablet-one laptop-one mobile-one clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-5164f961f mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="wrap mcb-wrap mcb-wrap-d22af76b3 two-third tablet-two-third laptop-two-third mobile-one mfn-nested-wrap clearfix" data-desktop-col="two-third" data-laptop-col="laptop-two-third" data-tablet-col="tablet-two-third" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-d22af76b3 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-58dde7476 one laptop-one tablet-one mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-58dde7476 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h1 style="color: white;">Solutions for Lipid Nanoparticle (LNP)<br> <span style="font-size: 26px;">Characterization in Product & Process Development<span></h1> <p style="font-size: 18px;">Wyatt solutions streamline LNP analysis, measuring size, polydispersity, NA payload, and stability with light scattering techniques, boosting productivity for research and QC.</p></div></div></div></div></div></div></div></div></section><section class="section mcb-section mfn-default-section mcb-section-ee1418d4b default-width" style="" ><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-ee1418d4b"><div class="wrap mcb-wrap mcb-wrap-f0fcc1c89 one-fourth tablet-one-fourth laptop-one-fourth mobile-one sticky-desktop clearfix" data-desktop-col="one-fourth" data-laptop-col="laptop-one-fourth" data-tablet-col="tablet-one-fourth" data-mobile-col="mobile-one" style="--sticky-offset-desktop:110px" ><div class="mcb-wrap-inner mcb-wrap-inner-f0fcc1c89 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="wrap mcb-wrap mcb-wrap-67e273674 one tablet-one laptop-one mobile-one mfn-item-custom-width mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-67e273674 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-cb5bfaa0a one laptop-one tablet-one mobile-one column_table_of_contents" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-cb5bfaa0a mcb-item-table_of_contents-inner"><div class="table_of_content clearfix " data-tags="H2"><div class="title"><h4 class="title-inner">Table of contents</h4></div><div class="table_of_content_wrapper"><ol class="mfn_toc_numbers"><li data-depth="1" ><i></i><a class="scroll" href="#introduction">Introduction</a></li><li><i></i><a class="scroll" href="#particle-size-distributions">Particle size distributions</a></li><li><i></i><a class="scroll" href="#payload-quantification">Payload quantification</a></li><li><i></i><a class="scroll" href="#mrna-dna">mRNA/DNA</a></li><li><i></i><a class="scroll" href="#process-analytical-technology-for-lnps">Process analytical technology for LNPs</a></li><li><i></i><a class="scroll" href="#instruments-for-lnp-characterization">Instruments for LNP characterization</a></li></ol></div></div> </div></div><div class="column mcb-column mcb-item-mbba7lx8 one laptop-one tablet-one mobile-one column_plain_text" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-mbba7lx8 mcb-item-plain_text-inner"><div class="desc"><a href="https://www.wyatt.com/products/request-product-info.html" class="sidebar-btn" target="_blank" rel="noopener noreferrer"> Request Product Information </a></div></div></div></div></div></div></div><div class="wrap mcb-wrap mcb-wrap-c41115729 three-fourth tablet-three-fourth laptop-three-fourth mobile-one clearfix" data-desktop-col="three-fourth" data-laptop-col="laptop-three-fourth" data-tablet-col="tablet-three-fourth" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-c41115729 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div id="introduction" class="wrap mcb-wrap mcb-wrap-a1e4055f2 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-a1e4055f2 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-w5oe9q94i one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-w5oe9q94i mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Introduction</h2></div></div></div><div class="column mcb-column mcb-item-05607s3s one-second laptop-one-second tablet-one-second mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-05607s3s mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>Lipid nanoparticle (LNP)-based delivery of pharmaceuticals holds much promise for novel gene therapies, oncology, and effective, rapid-response vaccines. Platform technologies that characterize and quantify LNP attributes across R&D, production and quality control will help realize that promise. <a href="https://www.selectscience.net/product-news/characterizing-lipid-nanoparticles-for-drug-delivery-latest-advancements-and-expert-opinion?artid=58536" target="_blank" rel="noopener">Click here</a> to read a SelectScience editorial article on the latest advancements and expert opinions on characterizing LNPs for drug delivery.</p> <p><b>Wyatt’s suite of solutions for analyzing critical LNP quality attributes including:</b></p> <ul> <li>Average size, polydispersity and detailed size distributions</li> <li>Particle concentration</li> <li>Size-based nucleic acid (NA) payload distribution</li> <li>Stability under a variety of stressors</li> </ul> <p>Many of these assays can be streamlined and automated for high throughput.</p> <p>Light scattering techniques are simple to operate and enhance productivity, while directly accessing the core biophysical properties that define these CQAs. Continue reading to learn about Wyatt’s solutions to industry and regulatory needs for LNPs and other nanopharmaceuticals.</p> <h3>Additional Resources</h3> <div style="display: flex; align-items: center; gap: 8px; margin-bottom: 10px;"><i class="fa-solid fa-arrow-up-right-from-square" style="color: #8a8a8d; font-size: 16px; opacity: 0.7;"></i> <a href="/solutions/lnp-formulation.html" target="_blank" rel="noopener">LNP formulation, development & characterization</a></div></div></div></div><div class="column mcb-column mcb-item-d9b1shskc one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-d9b1shskc mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid alignright no_border" ><div class="image_wrapper "><img width="991" height="976" src="https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21.jpg" class="scale-with-grid" alt="Lipid nanoparticle characterization factors: Size, Concentration, Stability, Charge, Screening, Payload, Efficiency." style="" decoding="async" fetchpriority="high" srcset="https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21.jpg 991w, https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21-300x295.jpg 300w, https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21-768x756.jpg 768w, https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21-148x146.jpg 148w, https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21-50x50.jpg 50w, https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21-76x75.jpg 76w, https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21-85x85.jpg 85w, https://www.wyatt.com/wp-content/uploads/2021/11/LNP-Characterization-11-21-80x80.jpg 80w" sizes="(max-width:767px) 480px, (max-width:991px) 100vw, 991px" /></div></div> </div></div><div class="column mcb-column mcb-item-hx749wtz one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-hx749wtz mcb-item-html-inner"><div class="mfn-html-editor-wrapper"><style> .cta-container { display: flex; flex-wrap: wrap; gap: 20px; justify-content: space-between; width: 100%; } .cta-box { border: 4px solid #EBEDEF; padding: 20px; flex: 1 1 calc(50% - 20px); /* Two boxes side by side with space between them */ box-sizing: border-box; display: flex; flex-direction: column; /* Ensures vertical alignment of content */ justify-content: space-between; /* Ensures the button is aligned to the bottom */ } .cta-box img { width: 150px; height: auto; display: block; margin: 0 auto 20px; /* Centers the image and adds space below it */ } .cta-box p { margin-bottom: 10px; flex-grow: 1; /* Pushes the button to the bottom */ } @media (max-width: 768px) { .cta-box { flex: 1 1 100%; /* Boxes stack on smaller screens */ } .cta-box img { width: 100%; height: auto; } </style> <div class="cta-container">  <div class="cta-box"> <h4>Publication List</h4> <p> Wyatt’s products characterize both viral and non-viral gene vectors. Publication list <i>PL9008: Key publications on the characterization of gene vectors by light scattering</i> lists some peer-reviewed publications describing how. </p> <a href="/library/request-pl9008.html" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Download Publication List </a> </div>  <div class="cta-box"> <h4>Webinar</h4> <p> Listen to the webinar “Size, Concentration, Payload and Quality: Comprehensive Characterization of LNP-RNA Therapeutics by Light Scattering”. </p> <a href="/library/size-concentration-payload-and-quality-comprehensive-characterization-of-lnp-rna-therapeutics-by-light-scattering-request.html" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fa-regular fa-circle-play cta-box-icon"></i> View Webinar </a> </div> </div></div></div></div></div></div><div id="particle-size-distributions" class="wrap mcb-wrap mcb-wrap-3abae2cb0 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-3abae2cb0 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-2wmxz04jp one laptop-one tablet-one mobile-one column_column column-margin-0px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-2wmxz04jp mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Particle size distributions</h2></div></div></div><div class="column mcb-column mcb-item-09ny8f6y one-second laptop-one-second tablet-one-second mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-09ny8f6y mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>Particle size, which affects biodistribution and cellular uptake, is one of the most important properties of LNPs. Multi-angle and dynamic light scattering (MALS, DLS) are utilized at different stages of LNP development, production and quality control.</p> <h3>Formulation development & quality control</h3> <p>Rapid screening of formulation conditions to produce LNPs in the desired size range and concentration reduces manual effort, improves product consistency and speeds up time to market. High-throughput DLS using a <a href="/products/instruments/dynapro-dynamic-light-scattering-plate-reader.html">DynaPro<sup>™</sup> Plate Reader</a> (DPR) measures size and particle concentration in standard 96, 384 or 1536 well plates, providing maximum convenience and lowest consumables cost without sacrificing accuracy or sensitivity.</p></div></div></div><div class="column mcb-column mcb-item-n4sr4fsbk one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-n4sr4fsbk mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:-10px;"><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2021/06/payload-image-1.png" alt="Graph showing size distribution of 3 lipid nanoparticle samples by radius (nm) vs. % mass, measured with a DLS Plate Reader." title="" width="400" height="320" style=""/></div><p class="wp-caption-text">Size distribution of three LNP preparations measured by a DLS Plate Reader.</p></div> </div></div><div class="column mcb-column mcb-item-4bf83893a one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-4bf83893a mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-plate-reader.jpg" alt="DynaPro PlateReader"> <div> <h4>Brochure Download</h4> <p style="margin: 0 0 10px;"> High-throughput DLS using a <a href="/products/instruments/dynapro-dynamic-light-scattering-plate-reader.html">DynaPro<sup>™</sup> Plate Reader</a> (DPR) measures size and particle concentration in standard 96, 384 or 1536 well plates, providing maximum convenience and lowest consumables cost without sacrificing accuracy or sensitivity. </p> <a href="/products/dynapro-plate-reader-product-info-request.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"> Request DynaPro PlateReader Brochure </a> </div> </div></div></div></div><div class="column mcb-column mcb-item-78w5ehbsmi one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-78w5ehbsmi mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>High-resolution size distributions with FFF-MALS</h3> </div></div></div><div class="column mcb-column mcb-item-dprc2fq5 one-second laptop-one-second tablet-one-second mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-dprc2fq5 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>Field-flow fractionation coupled to multi-angle light scattering (<a href="/solutions/techniques/fff-mals-characterization-of-nanoparticles-colloids-macromolecules.html">FFF-MALS</a>) is the premier method for accurate and quantitative LNP size distributions, providing levels of detail, accuracy, repeatability and automation not possible with other methods.</p></div></div></div><div class="column mcb-column mcb-item-f21td2x24 one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-f21td2x24 mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:-10px;"><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2021/06/FFF-Diagram-800.jpg" alt="FFF diagram showing size-based separation: smaller particles with higher diffusion coefficients elute first." title="" width="350" height="375" style=""/></div><p class="wp-caption-text">Field-flow fractionation (FFF) separates particles according to diffusion coefficient, i.e. hydrodynamic radius.</p></div> </div></div><div class="column mcb-column mcb-item-om63o8af one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-om63o8af mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb_webinars.jpg" alt="Webinar Thumbnail"> <div> <h4>Webinar</h4> <p style="margin: 0 0 10px;"> The implications of FFF-MALS for regulatory aspects of LNP development were presented by Dr. Fanny Caputo in the webinar <i>Measuring physical properties of liposomes and LNPs for RNA delivery with multidetector asymmetric-flow field-flow fractionation</i>. </p> <a href="/library/measuring-physical-properties-of-liposomes-and-lnps-for-rna-delivery-with-multidetector-asymmetric-flow-field-flow-fractionation-request.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fa-regular fa-circle-play cta-box-icon"></i> View Webinar </a> </div> </div></div></div></div><div class="column mcb-column mcb-item-88hyw45i one-second laptop-one-second tablet-one-second mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-88hyw45i mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>ASTRA’s Number Density method provides direct measurement of particle size and concentration derived from the light scattering intensity. These calculations can be applied to a variety of common gene delivery vehicles, including viruses, virus-like particles and lipid nanoparticles. Learn more about the sensitivity and linearity of this method in this paper published by scientists at the CDC: <a href="https://www.sciencedirect.com/science/article/abs/pii/S0166093413002802?via%3Dihub" target="_blank" rel="noopener">Quantitation of influenza virus using field-flow fractionation and multi-angle light scattering for quantifying influenza A particles</a>.</p> <div style="background-color: #f9f9f9; padding: 15px;"> <p>Wyatt’s solutions for characterizing a variety of gene therapy products are described in the brochure <a href="/request-biologics-guide.html"><i>Characterization of Biologics and Complex Drugs</i></a>.</p> </div></div></div></div><div class="column mcb-column mcb-item-xignz4qs1 one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-xignz4qs1 mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:-10px;"><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2021/06/lnp-image-3.png" alt="Graph showing size high-resolution size distributions of three lipid nanoparticle preparations measured by FFF-MALS." title="" width="350" height="366" style=""/></div><p class="wp-caption-text">Size distribution of the same three LNP preparations as above but measured by FFF-MALS.</p></div> </div></div><div class="column mcb-column mcb-item-5q0n46k4 one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-5q0n46k4 mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-white-paper-wp2608.webp" alt="White Paper Thumbnail"> <div> <h4>White Paper</h4> <p style="margin: 0 0 10px;"> <p>More than just size distributions may be determined with FFF-MALS. A variety of applications of FFF-MALS to characterization of liposomes and LNPs, including preclinical characterization of Lipidots and the kinetics of drug transfer between nanocarriers and a proxy for the cellular membrane, are presented in the white paper <a href="https://www.wyatt.com/library/webinars/characterization-of-lipid-nanoparticle-drug-formulations.html"><i>Characterization of Lipid Nanoparticle Drug Formulations</i></a> and in <i>WP2608: Lipid nanoparticle and liposome characterization with FFF-MALS</i>.</p> <a href="/library/request-wp2608.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Download WP2608 </a> </div> </div></div></div></div></div></div><div id="payload-quantification" class="wrap mcb-wrap mcb-wrap-de19zk636 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-de19zk636 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-7071d8eb3 one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-7071d8eb3 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Payload quantification</h2></div></div></div><div class="column mcb-column mcb-item-999a5a183 one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-999a5a183 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>Online payload analysis by MALS-UV-dRI following SEC or FFF</h3> </div></div></div><div class="column mcb-column mcb-item-bg370swh one-second laptop-one-second tablet-one-second mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-bg370swh mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>ASTRA's LNP Analysis module quantitates the nucleic acid weight fraction using online MALS, UV260 and dRI detectors coupled to SEC or FFF. The same data simultaneously quantify many other quality attributes, such as size distribution, particle concentration, morphology, encapsulation efficiency, mRNA concentration and lipid concentration. The method was validated against conventional offline measurements in “<a href="https://doi.org/10.1016/j.jchromb.2021.123015" target="_blank" rel="noopener">Enabling online determination of the size-dependent RNA content of lipid nanoparticle-based RNA formulations</a>.”</p> <p><a class="button button_size_2" href="/products/request-lnp-information.html" style="background-color:#0065a4!important;color:#ffffff;" title=""><span class="button_label">Learn More</span></a> </p></div></div></div><div class="column mcb-column mcb-item-u93729t5o one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-u93729t5o mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:-10px;"><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2021/11/LNP-RNA-Attributes-Characterization-Technologies-1000.jpg" alt="The SEC or FFF-MALS multidetector technique delivers quality attributes that usually need seven different instruments or workflows." title="" width="400" height="568" style=""/></div></div> </div></div><div class="column mcb-column mcb-item-ohtv1ld2q one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-ohtv1ld2q mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>The FFF-MALS-UV-dRI system</h3></div></div></div><div class="column mcb-column mcb-item-guqbkzilj three-fifth laptop-three-fifth tablet-three-fifth mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-guqbkzilj mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>Though SEC has been used to separate LNPs, FFF is the tool-of-choice for LNP and other bioNPs owing to its tunable resolution and better mass recovery. Wyatt’s FFF-MALS system for LNP payload analysis comprises an <a href="/products/instruments/eclipse-field-flow-fractionation-system.html">Eclipse<sup>™</sup></a> FFF instrument, <a href="/products/instruments/dawn-multi-angle-light-scattering-detector.html">DAWN<sup>™</sup></a> MALS instrument (with optional embedded <a>WyattQELS<sup>™</sup></a> DLS module), <a href="/products/instruments/optilab-refractive-index-detector.html">Optilab<sup>™</sup></a> differential refractive index (dRI) detector and industry-standard HPLC pump, autosampler and UV detector from Agilent Technologies. A fraction collector may be added downstream.</p> <p>The entire system is orchestrated by <a href="/products/software/vision.html">VISION<sup>™</sup></a>, Wyatt’s innovative software for FFF method design and instrument control. Data are collected and analyzed with <a href="/products/software/astra.html">ASTRA<sup>™</sup></a>, the premier software for MALS and DLS. VISION and ASTRA are both available in <a href="/products/services/21-cfr-part-11-compliance.html">21 CFR Part 11 compliant versions</a>.</p></div></div></div><div class="column mcb-column mcb-item-5c2cd292b two-fifth laptop-two-fifth tablet-two-fifth mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-5c2cd292b mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:-10px;"><div class="image_wrapper "><img width="293" height="300" src="https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000-293x300.jpg" class="scale-with-grid" alt="A Wyatt FFF-MALS system, including an Eclipse, DAWN, and Optilab instrument." style="" decoding="async" srcset="https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000-293x300.jpg 293w, https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000-768x786.jpg 768w, https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000-73x75.jpg 73w, https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000-488x500.jpg 488w, https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000-469x480.jpg 469w, https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000-480x492.jpg 480w, https://www.wyatt.com/wp-content/uploads/2024/04/WAT-Arc-HPLC-Optilab-DAWN-Eclipse-1000.jpg 1000w" sizes="(max-width:767px) 293px, 293px" /></div><p class="wp-caption-text">Wyatt’s FFF-MALS system comprising Eclipse, DAWN and Optilab.</p></div> </div></div><div class="column mcb-column mcb-item-000abe7c4 one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-000abe7c4 mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img style="width: 150px !important;" src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-solutions-guide.webp" alt="Solutions Guide Thumbnail"> <div> <h4>Solutions Guide</h4> <p style="margin: 0 0 10px;"> <p>Wyatt’s product lines and application range are outlined in <i>Solutions for Macromolecular and Nanoparticle Characterization</i>. </p> <a href="/library/solutions-guide-request.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"> Request the Solutions Guide </a> </div> </div></div></div></div></div></div><div id="mrna-dna" class="wrap mcb-wrap mcb-wrap-cnu8kpx9 one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-cnu8kpx9 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-d3e497343 one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-d3e497343 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">mRNA/DNA</h2></div></div></div><div class="column mcb-column mcb-item-04672cef2 one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-04672cef2 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>mRNA biophysical attributes</h3></div></div></div><div class="column mcb-column mcb-item-1u9b2ai57 one-second laptop-one-second tablet-one-second mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-1u9b2ai57 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>As described in application note <i>AN1616: SEC-MALS methods for characterizing mRNA</i>, key biophysical attributes of mRNA are quantified by SEC-MALS plus DLS. This analysis determines molecular weight, percentage of aggregates, radius of gyration <i>R</i><sub>g</sub> and hydrodynamic radius <i>R</i><sub>h</sub>. The relationship between <i>M</i><sub>w</sub> and <i>R</i><sub>g</sub> identifies single- or double-stranded RNA, while the ratio <i>R</i><sub>g</sub>:<i>R</i><sub>h</sub> indicates molecular conformation. This method can be readily adopted to further study how these attributes are affected by mRNA preparation, formulation and storage conditions.</p></div></div></div><div class="column mcb-column mcb-item-1268423ab one-second laptop-one-second tablet-one-second mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-1268423ab mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:-10px;"><div class="image_wrapper "><img class="scale-with-grid" src="https://www.wyatt.com/wp-content/uploads/2021/06/Biophysical-Attributes-Graph-Update.jpg" alt="SEC-MALS and DLS quantify fLuc and Epo mRNA attributes: Mw, % aggregates, Rg, Rh, RNA structure, and conformation, aiding stability." title="" width="450" height="500" style=""/></div></div> </div></div><div class="column mcb-column mcb-item-t7itdnmjm one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-t7itdnmjm mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-app-note-1616.webp" alt="Application Note Thumbnail"> <div> <h4>Application Note</h4> <p style="margin: 0 0 10px;"> <p>SEC-MALS Method for Characterizing mRNA Biophysical Attributes. </p> <a href="/library/request-an1616.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Download AN1616 </a> </div> </div></div></div></div></div></div><div id="process-analytical-technology-for-lnps" class="wrap mcb-wrap mcb-wrap-fb85u3vom one tablet-one laptop-one mobile-one mfn-nested-wrap clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="" ><div class="mcb-wrap-inner mcb-wrap-inner-fb85u3vom mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-ca018870f one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-ca018870f mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Process analytical technology for LNPs</h2></div></div></div><div class="column mcb-column mcb-item-50c46d964 one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-50c46d964 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>LNP process development and analytics</h3></div></div></div><div class="column mcb-column mcb-item-onbvb25lp three-fourth laptop-three-fourth tablet-three-fourth mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-onbvb25lp mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><p>Once a successful LNP/mRNA platform has been developed, scaling up the process is facilitated by real-time multi-angle light scattering (RT-MALS). With <a href="/products/instruments/ultradawn.html">ultraDAWN<sup>™</sup></a> either in-line or on-line, continuous monitoring of critical quality attributes like particle size and concentration is achieved. Real-time monitoring of liposome size in a production environment is described in <i>AN8006: In line monitoring of liposome size by RT-MALS</i>.</p></div></div></div><div class="column mcb-column mcb-item-a6ef54e3f one-fourth laptop-one-fourth tablet-one-fourth mobile-one column_image" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-a6ef54e3f mcb-item-image-inner"><div class="image_frame image_item no_link scale-with-grid aligncenter no_border" style="margin-bottom:-10px;"><div class="image_wrapper "><img width="500" height="431" src="https://www.wyatt.com/wp-content/uploads/2019/11/RT-MALS-Manufacturing.jpg" class="scale-with-grid" alt="Lab technician in protective gear examines documents next to industrial lab equipment in a sterile, controlled environment." style="" decoding="async" srcset="https://www.wyatt.com/wp-content/uploads/2019/11/RT-MALS-Manufacturing.jpg 500w, https://www.wyatt.com/wp-content/uploads/2019/11/RT-MALS-Manufacturing-300x259.jpg 300w, https://www.wyatt.com/wp-content/uploads/2019/11/RT-MALS-Manufacturing-169x146.jpg 169w, https://www.wyatt.com/wp-content/uploads/2019/11/RT-MALS-Manufacturing-50x43.jpg 50w, https://www.wyatt.com/wp-content/uploads/2019/11/RT-MALS-Manufacturing-87x75.jpg 87w" sizes="(max-width:767px) 480px, 500px" /></div></div> </div></div><div class="column mcb-column mcb-item-beicl6po2 one laptop-one tablet-one mobile-one column_html" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-beicl6po2 mcb-item-html-inner"><div class="mfn-html-editor-wrapper"> <div class="responsive-container"> <img src="https://www.wyatt.com/wp-content/uploads/2024/11/thumb-app-note-8006.webp" alt="Application Note Thumbnail"> <div> <h4>Application Note</h4> <p style="margin: 0 0 10px;"> <p>AN8006: In line monitoring of liposome size by RT-MALS </p> <a href="/library/request-an8006.html" style="" class="cta-box-btn" target="_blank" rel="noopener noreferrer"><i class="fas fa-file-pdf cta-box-icon"></i> Download AN8006 </a> </div> </div></div></div></div><div class="column mcb-column mcb-item-21a679436 one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-21a679436 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h3>Real-time MALS for PAT</h3> <p>RT-MALS can be applied during process development, to eliminate time-consuming off-line measurements of fractions by DLS or particle tracking analysis (PTA), as well as to monitor and flag potential deviations during full GMP production. In GMP operation, <a href="/products/software/observer.html">OBSERVER<sup>™</sup></a> RT-MALS software becomes an OPC-UA server in order to integrate with process control. To learn more, view the webinar <a href="/library/webinars/real-time-process-analytics-and-control-for-vaccine-nanoparticles-and-macromolecules.html"><i>Real-Time Process Analytics and Control for Vaccine Nanoparticles and Macromolecules</i></a> or request the ultraDAWN brochure.</p></div></div></div><div class="column mcb-column mcb-item-61eltthwh one-second laptop-one-second tablet-one-second mobile-one column_column" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-61eltthwh mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><a class="button button_size_2" href="/products/ultradawn-product-info-request.html" style="background-color:#0065a4!important;color:#ffffff;" target="_blank" title=""><span class="button_label">Request ultraDAWN brochure</span></a> </div></div></div></div></div></div></div></div></section><section class="section mcb-section mfn-default-section mcb-section-adc519fdb" id="instruments-for-lnp-characterization" style="padding-bottom:10px" ><div class="mcb-background-overlay"></div><div class="section_wrapper mfn-wrapper-for-wraps mcb-section-inner mcb-section-inner-adc519fdb"><div class="wrap mcb-wrap mcb-wrap-7684f7124 one tablet-one laptop-one mobile-one valign-top clearfix" data-desktop-col="one" data-laptop-col="laptop-one" data-tablet-col="tablet-one" data-mobile-col="mobile-one" style="padding:;background-color:" ><div class="mcb-wrap-inner mcb-wrap-inner-7684f7124 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-bf6efda05 one laptop-one tablet-one mobile-one column_column column-margin-10px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-bf6efda05 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><h2 class="section-headline">Instruments for LNP characterization</h2></div></div></div></div></div><div class="wrap mcb-wrap mcb-wrap-24d81a8be one-third tablet-one-third laptop-one-third mobile-one valign-top clearfix" data-desktop-col="one-third" data-laptop-col="laptop-one-third" data-tablet-col="tablet-one-third" data-mobile-col="mobile-one" style="padding:;background-color:" ><div class="mcb-wrap-inner mcb-wrap-inner-24d81a8be mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-0da49aa72 one laptop-one tablet-one mobile-one column_column column-margin-0px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-0da49aa72 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><span><p align="center"><img src="/wp-content/uploads/2021/06/DAWN-350.jpg"></p> <br> <p align="center" style="color:#0065a4"><b>DAWN multi-angle light scattering instrument</b></p> <br> <p align="center"><a class="button button_size_2" href="/products/dawn-product-info-request.html" style="background-color:#0065a4!important;color:#ffffff;" title=""><span class="button_label">Request DAWN brochure</span></a> </p> </span></div></div></div></div></div><div class="wrap mcb-wrap mcb-wrap-5819792c3 one-third tablet-one-third laptop-one-third mobile-one valign-top clearfix" data-desktop-col="one-third" data-laptop-col="laptop-one-third" data-tablet-col="tablet-one-third" data-mobile-col="mobile-one" style="padding:;background-color:" ><div class="mcb-wrap-inner mcb-wrap-inner-5819792c3 mfn-module-wrapper mfn-wrapper-for-wraps" ><div class="mcb-wrap-background-overlay"></div><div class="column mcb-column mcb-item-090d413a0 one laptop-one tablet-one mobile-one column_column column-margin-0px" style="" ><div class="mcb-column-inner mfn-module-wrapper mcb-column-inner-090d413a0 mcb-item-column-inner"><div class="column_attr mfn-inline-editor clearfix" style=""><span><p align="center"><img src="/wp-content/uploads/2021/06/Eclipse-350.jpg"></p> <br> <p align="center" 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