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target="">Hemingway Letters</a></li><li><a href="/core/publications/collections/shakespeare-survey" target="">Shakespeare Survey</a></li><li><a href="/core/publications/collections/stahl-online" target="">Stahl Online</a></li><li><a href="/core/publications/collections/the-correspondence-of-isaac-newton" target="">The Correspondence of Isaac Newton</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Elements</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Explore</li><ol><!--[--><li><a href="/core/publications/elements" target="">About Elements</a></li><li><a href="/core/publications/elements/cambridge-elements-series" target="">Elements series</a></li><li><a href="/core/publications/elements/published-elements?aggs%5BopenAccess%5D%5Bfilters%5D=7275BA1E84CA769210167A6A66523B47&aggs%5BproductTypes%5D%5Bfilters%5D=ELEMENT&searchWithinIds=ECFD8F5C64F47F3F5A3D395C15B7C493" target="">Open access Elements</a></li><li><a href="/core/publications/elements/published-elements?aggs%5BproductTypes%5D%5Bfilters%5D=ELEMENT&aggs%5BproductDate%5D%5Bfilters%5D=Last%203%20months&searchWithinIds=ECFD8F5C64F47F3F5A3D395C15B7C493" target="">New Elements</a></li><!--]--></ol><!--]--><!--[--><li>Subjects (A-E)</li><ol><!--[--><li><a href="/core/elements/subject/Anthropology/2E44A5AF2838E017617A26DD79FAEAEE" target="">Anthropology</a></li><li><a href="/core/elements/subject/Archaeology/63A50B5368A9F97F8AA2D6AB965B5F4C" target="">Archaeology</a></li><li><a href="/core/elements/subject/Classical%20Studies/DDC63B7F5792FE2A95D1FB15F76E3F42" target="">Classical Studies</a></li><li><a href="/core/elements/subject/Computer%20Science/A57E10708F64FB69CE78C81A5C2A6555" target="">Computer Science</a></li><li><a href="/core/elements/subject/Drama,%20Theatre,%20Performance%20Studies/2825E4E39F2D641B36543EE80FB1DEA3" target="">Drama, Theatre, Performance Studies</a></li><li><a href="/core/elements/subject/Earth%20and%20Environmental%20Sciences/F470FBF5683D93478C7CAE5A30EF9AE8" target="">Earth and Environmental Sciences</a></li><li><a href="/core/elements/subject/Economics/FA44491F1F55F917C43E9832715B9DE7" target="">Economics</a></li><li><a href="/core/elements/subject/Education/550D00F8DF590F2598CF7CC0038E24D1" target="">Education</a></li><li><a href="/core/elements/subject/Engineering/CCC62FE56DCC1D050CA1340C1CCF46F5" target="">Engineering</a></li><!--]--></ol><!--]--><!--[--><li> Subjects (F-O)</li><ol><!--[--><li><a href="/core/elements/subject/Film,%20Media,%20Mass%20Communication/4B91F10E834814A90CE718E7831E492F" target="">Film, Media, Mass Communication</a></li><li><a href="/core/elements/subject/History/66BE42A30172E280FDE64F8EE2F485B0" target="">History</a></li><li><a href="/core/elements/subject/Language%20and%20Linguistics/140D314098408C26BDF3009F7FF858E9" target="">Language and Linguistics</a></li><li><a href="/core/elements/subject/Law/7C9FB6788DD8D7E6696263BC774F4D5B" target="">Law</a></li><li><a href="/core/elements/subject/Life%20Sciences/E044EF2F61B601378786E9EDA901B2D5" target="">Life Sciences</a></li><li><a href="/core/elements/subject/Literature/F2434ADC122145767C6C3B988A8E9BD5" target="">Literature</a></li><li><a href="/core/elements/subject/Management/0EDCC0540639B06A5669BDEEF50C4CBE" target="">Management</a></li><li><a href="/core/elements/subject/Mathematics/FA1467C44B5BD46BB8AA6E58C2252153" target="">Mathematics</a></li><li><a href="/core/elements/subject/Medicine/66FF02B2A4F83D9A645001545197F287" target="">Medicine</a></li><li><a href="/core/elements/subject/Music/A370B5604591CB3C7F9AFD892DDF7BD1" target="">Music</a></li><!--]--></ol><!--]--><!--[--><li> Subjects (P-Z)</li><ol><!--[--><li><a href="/core/elements/subject/Philosophy/2D1AC3C0E174F1F1A93F8C7DE19E0FAB" target="">Philosophy</a></li><li><a href="/core/elements/subject/Physics%20and%20Astronomy/DBFB610E9FC5E012C011430C0573CC06" target="">Physics and Astronomy</a></li><li><a href="/core/elements/subject/Politics%20and%20International%20Relations/3BF83347E5E456DAC34F3FABFC8BBF4E" target="">Politics and International Relations</a></li><li><a href="/core/elements/subject/Psychology/21B42A72BA3E4CB0E3315E5B1B71B07F" target="">Psychology</a></li><li><a href="/core/elements/subject/Religion/53E51D24FB488962B9364A2C4B45D1C3" target="">Religion</a></li><li><a href="/core/elements/subject/Sociology/0E2CD53A93003DF17E52D753F6E90683" target="">Sociology</a></li><li><a href="/core/elements/subject/Statistics%20and%20Probability/3150B8B0D1B0B4E8DC17EC9EDFD9CA26" target="">Statistics and Probability</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Textbooks</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Explore</li><ol><!--[--><li><a href="/highereducation/" target="">Cambridge Higher Education</a></li><li><a href="/highereducation/services/librarians/title-list" target="">Title list</a></li><li><a href="/highereducation/search?sortBy=publication_date&aggs=%24productDate%24Last%25206%2520months%3Atrue%26Last%252012%2520months%3Atrue%26Last%25203%2520years%3Atrue%26Over%25203%2520years%3Atrue%3B%3B&event=SE-AU_PREF" target="">New titles</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Collections</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Book collections</li><ol><!--[--><li><a href="/core/publications/collections/cambridge-companions" target="">Cambridge Companions</a></li><li><a href="/core/publications/collections/cambridge-editions" target="">Cambridge Editions</a></li><li><a href="/core/publications/collections/cambridge-histories" target="">Cambridge Histories</a></li><li><a href="/core/publications/collections/cambridge-library-collection" target="">Cambridge Library Collection</a></li><li><a href="/core/publications/collections/cambridge-shakespeare" target="">Cambridge Shakespeare</a></li><li><a href="/core/publications/collections/cambridgehandbooks" target="">Cambridge Handbooks</a></li><!--]--></ol><!--]--><!--[--><li> Book collections (cont.)</li><ol><!--[--><li><a href="/core/publications/collections/dispute-settlement-reports-online" target="">Dispute Settlement Reports Online</a></li><li><a href="/core/publications/collections/flip-it-open" target="">Flip it Open</a></li><li><a href="/core/publications/collections/hemingway-letters" target="">Hemingway Letters</a></li><li><a href="/core/publications/collections/shakespeare-survey" target="">Shakespeare Survey</a></li><li><a href="/core/publications/collections/stahl-online" target="">Stahl Online</a></li><li><a href="/core/publications/collections/the-correspondence-of-isaac-newton" target="">The Correspondence of Isaac Newton</a></li><!--]--></ol><!--]--><!--[--><li>Journal collections</li><ol><!--[--><li><a href="/core/publications/collections/cambridge-forum" target="">Cambridge Forum</a></li><li><a href="/core/publications/collections/cambridge-law-reports-collection" target="">Cambridge Law Reports Collection</a></li><li><a href="/core/publications/collections/cambridge-prisms" target="">Cambridge Prisms</a></li><li><a href="/core/publications/collections/research-directions" target="">Research Directions</a></li><!--]--></ol><!--]--><!--[--><li>Series</li><ol><!--[--><li><a href="/core/publications/collections/series" target="">All series</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Partners</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Partners</li><ol><!--[--><li><a href="/core/publications/publishing-partners/agenda-publishing" target="">Agenda Publishing</a></li><li><a href="/core/publications/publishing-partners/amsterdam-university-press" target="">Amsterdam University Press</a></li><li><a href="/core/publications/publishing-partners/anthem-press" target="">Anthem Press</a></li><li><a href="/core/publications/publishing-partners/boydell-brewer" target="">Boydell & Brewer</a></li><li><a href="/core/publications/publishing-partners/bristol-university-press" target="">Bristol University Press</a></li><li><a href="/core/publications/publishing-partners/edinburgh-university-press" target="">Edinburgh University Press</a></li><li><a href="/core/publications/publishing-partners/emirates-center" target="">Emirates Center for Strategic Studies and Research</a></li><li><a href="/core/publications/publishing-partners/facet-publishing" target="">Facet Publishing</a></li><!--]--></ol><!--]--><!--[--><li> Partners (cont.)</li><ol><!--[--><li><a href="/core/publications/publishing-partners/foundation-books" target="">Foundation Books</a></li><li><a href="/core/publications/publishing-partners/intersentia" target="">Intersentia</a></li><li><a href="/core/publications/publishing-partners/iseas" target="">ISEAS-Yusof Ishak Institute</a></li><li><a href="/core/publications/publishing-partners/jagiellonian-university-press" target="">Jagiellonian University Press</a></li><li><a href="/core/publications/publishing-partners/royal-economic-society" target="">Royal Economic Society</a></li><li><a href="/core/publications/publishing-partners/unisa-press" target="">Unisa Press</a></li><li><a href="/core/publications/publishing-partners/university-adelaide-press" target="">The University of Adelaide Press</a></li><li><a href="/core/publications/publishing-partners/wits-university-press" target="">Wits University Press</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Services</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>About</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>About Cambridge Core</li><ol><!--[--><li><a href="/core/services/about/about" target="">About</a></li><li><a href="/core/services/about/accessibility" target="">Accessibility</a></li><li><a href="/core/services/about/crossmark-policy" target="">CrossMark policy</a></li><li><a href="/core/services/about/ethical-standards" target="">Ethical Standards</a></li><!--]--></ol><!--]--><!--[--><li>Environment and sustainability</li><ol><!--[--><li><a href="/core/services/about/environment-and-sustainability" target="">Environment and sustainability</a></li><li><a href="/core/services/about/reducing-print" target="">Reducing print</a></li><li><a href="/core/services/about/journals-moving-to-online-only" target="">Journals moving to online only</a></li><!--]--></ol><!--]--><!--[--><li>Guides</li><ol><!--[--><li><a href="/core/services/about/user-guides" target="">User guides</a></li><li><a href="/core/services/about/user-guides-and-videos" target="">User Guides and Videos</a></li><li><a href="/core/services/about/support-videos" target="">Support Videos</a></li><li><a href="/core/services/about/training" target="">Training</a></li><!--]--></ol><!--]--><!--[--><li>Help</li><ol><!--[--><li><a href="https://corehelp.cambridge.org/" target="">Cambridge Core help</a></li><li><a href="https://corehelp.cambridge.org/hc/en-gb/p/contact-information" target="">Contact us</a></li><li><a href="https://corehelp.cambridge.org/hc/en-gb/requests/new" target="">Technical support</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Agents</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Services for agents</li><ol><!--[--><li><a href="/core/services/agents/services-for-agents" target="">Services for agents</a></li><li><a href="/core/services/agents/journals-for-agents" target="">Journals for agents</a></li><li><a href="/core/services/agents/books-for-agents" target="">Books for agents</a></li><li><a href="/core/services/agents/price-list" target="">Price list</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Authors</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Journals</li><ol><!--[--><li><a href="/core/services/authors/journals" target="">Journals</a></li><li><a href="/core/services/authors/journal-publishing-statistics" target="">Journal publishing statistics</a></li><li><a href="/core/services/authors/corresponding-author" target="">Corresponding author</a></li><li><a href="/core/services/authors/seeking-permission-to-use-copyrighted-material" target="">Seeking permission to use copyrighted material</a></li><li><a href="/core/services/authors/publishing-supplementary-material" target="">Publishing supplementary material</a></li><li><a href="/core/services/authors/writing-an-effective-abstract" target="">Writing an effective abstract</a></li><li><a href="/core/services/authors/journal-production-faqs" target="">Journal production - FAQs</a></li><!--]--></ol><!--]--><!--[--><li>Journals (cont.)</li><ol><!--[--><li><a href="/core/services/authors/author-affiliations" target="">Author affiliations</a></li><li><a href="/core/services/authors/co-reviewing-policy" target="">Co-reviewing policy</a></li><li><a href="/core/services/authors/digital-author-publishing-agreement-faqs" target="">Digital Author Publishing Agreement - FAQs</a></li><li><a href="/core/services/authors/anonymising-your-manuscript" target="">Anonymising your manuscript</a></li><li><a href="/core/services/authors/publishing-open-access" target="">Publishing open access</a></li><li><a href="/core/services/authors/converting-your-article-to-open-access" target="">Converting your article to open access</a></li><li><a href="/core/services/authors/publishing-open-access-webinars" target="">Publishing Open Access - webinars</a></li><!--]--></ol><!--]--><!--[--><li>Journals (cont.)</li><ol><!--[--><li><a href="/core/services/authors/preparing-and-submitting-your-paper" target="">Preparing and submitting your paper</a></li><li><a href="/core/services/authors/publishing-an-accepted-paper" target="">Publishing an accepted paper</a></li><li><a href="/core/services/authors/promoting-your-published-paper" target="">Promoting your published paper</a></li><li><a href="/core/services/authors/measuring-impact" target="">Measuring impact</a></li><li><a href="/core/services/authors/journals-artwork-guide" target="">Journals artwork guide</a></li><li><a href="/core/services/authors/using-orcid" target="">Using ORCID</a></li><!--]--></ol><!--]--><!--[--><li>Books</li><ol><!--[--><li><a href="/core/services/authors/books" target="">Books</a></li><li><a href="/core/services/authors/marketing-your-book" target="">Marketing your book</a></li><li><a href="/core/services/authors/elements-user-guides" target="">Author guides for Cambridge Elements</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Corporates</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Corporates</li><ol><!--[--><li><a href="/core/services/corporates/commercial-reprints" target="">Commercial reprints</a></li><li><a href="/core/services/corporates/advertising" target="">Advertising</a></li><li><a href="/core/services/corporates/sponsorship" target="">Sponsorship</a></li><li><a href="/core/services/corporates/book-special-sales" target="">Book special sales</a></li><li><a href="/core/services/corporates/contact-us" target="">Contact us</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Editors</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Information</li><ol><!--[--><li><a href="/core/services/editors/journal-development" target="">Journal development</a></li><li><a href="/core/services/editors/peer-review-for-editors" target="">Peer review for editors</a></li><li><a href="/core/services/editors/open-access-for-editors" target="">Open access for editors</a></li><li><a href="/core/services/editors/policies-and-guidelines" target="">Policies and guidelines</a></li><!--]--></ol><!--]--><!--[--><li>Resources</li><ol><!--[--><li><a href="/core/services/editors/the-editors-role" target="">The editor's role</a></li><li><a href="/core/services/editors/open-research-for-editors" target="">Open research for editors</a></li><li><a href="/core/services/editors/engagement-and-promotion" target="">Engagement and promotion</a></li><li><a href="/core/services/editors/blogging" target="">Blogging</a></li><li><a href="/core/services/editors/social-media" target="">Social media</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Librarians</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Information</li><ol><!--[--><li><a href="/core/services/librarians/open-access-for-librarians" target="">Open Access for Librarians</a></li><li><a href="https://www.cambridge.org/core/services/open-access-policies/read-and-publish-agreements" target="">Transformative agreements</a></li><li><a href="/core/services/librarians/transformative-agreements-faqs" target="">Transformative Agreements - FAQs</a></li><li><a href="/core/services/librarians/evidence-based-acquisition" target="">Evidence based acquisition</a></li><li><a href="/core/services/librarians/ebook-news-and-updates" target="">ebook news & updates</a></li><li><a href="/core/services/librarians/cambridge-libraries-of-the-world-podcast" target="">Cambridge libraries of the world podcast</a></li><li><a href="/core/services/librarians/purchasing-models" target="">Purchasing models</a></li><li><a href="/core/services/librarians/journals-publishing-updates" target="">Journals Publishing Updates</a></li><!--]--></ol><!--]--><!--[--><li>Products</li><ol><!--[--><li><a href="/core/services/librarians/cambridge-frontlist" target="">Cambridge frontlist</a></li><li><a href="/core/services/librarians/cambridge-journals-digital-archive" target="">Cambridge journals digital archive</a></li><li><a href="/core/services/librarians/hot-topics" target="">Hot topics</a></li><li><a href="/core/services/librarians/other-digital-products" target="">Other digital products</a></li><li><a href="/core/services/librarians/perpetual-access-products" target="">Perpetual access products</a></li><li><a href="/core/services/librarians/price-list" target="">Price list</a></li><li><a href="/core/services/librarians/developing-country-programme" target="">Developing country programme</a></li><li><a href="/core/services/librarians/new-content" target="">New content</a></li><!--]--></ol><!--]--><!--[--><li>Tools</li><ol><!--[--><li><a href="/core/eligibility-checker" target="">Eligibility checker</a></li><li><a href="https://www.cambridge.org/core/services/open-access-policies/read-and-publish-agreements" target="">Transformative agreements</a></li><li><a href="https://www.cambridge.org/core/services/librarians/kbart" target="">KBART</a></li><li><a href="https://www.cambridge.org/core/services/librarians/marc-records" target="">MARC records</a></li><li><a href="/core/services/librarians/using-marcedit-for-marc-records" target="">Using MARCEdit for MARC records</a></li><li><a href="/core/services/librarians/inbound-openurl-specifications" target="">Inbound OpenURL specifications</a></li><li><a href="/core/services/librarians/counter-report-types" target="">COUNTER report types</a></li><!--]--></ol><!--]--><!--[--><li>Resources</li><ol><!--[--><li><a href="/core/services/librarians/catalogues-and-resources" target="">Catalogues and resources</a></li><li><a href="/core/services/librarians/making-the-most-of-your-eba" target="">Making the most of your EBA</a></li><li><a href="/core/services/librarians/posters" target="">Posters</a></li><li><a href="/core/services/librarians/leaflets-and-brochures" target="">Leaflets and brochures</a></li><li><a href="/core/services/librarians/additional-resources" target="">Additional resources</a></li><li><a href="/core/services/librarians/find-my-sales-contact" target="">Find my sales contact</a></li><li><a href="/core/services/librarians/webinars" target="">Webinars</a></li><li><a href="/core/services/librarians/read-and-publish-resources" target="">Read and publish resources</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Peer review</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Peer review</li><ol><!--[--><li><a href="/core/services/peer-review/how-to-peer-review-journal-articles" target="">How to peer review journal articles</a></li><li><a href="/core/services/peer-review/how-to-peer-review-book-proposals" target="">How to peer review book proposals</a></li><li><a href="/core/services/peer-review/how-to-peer-review-registered-reports" target="">How to peer review Registered Reports</a></li><li><a href="/core/services/peer-review/peer-review-faqs" target="">Peer review FAQs</a></li><li><a href="/core/services/peer-review/ethics-in-peer-review" target="">Ethics in peer review</a></li><li><a href="/core/services/peer-review/online-peer-review-systems" target="">Online peer review systems</a></li><li><a href="/core/services/peer-review/a-guide-to-publons" target="">A guide to Publons</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Publishing ethics</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Journals </li><ol><!--[--><li><a href="/core/services/publishing-ethics/publishing-ethics-guidelines-journals" target="">Publishing ethics guidelines for journals</a></li><li><a href="/core/services/publishing-ethics/core-editorial-policies-journals" target="">Core editorial policies for journals</a></li><li><a href="/core/services/publishing-ethics/authorship-and-contributorship-journals" target="">Authorship and contributorship for journals</a></li><li><a href="/core/services/publishing-ethics/affiliations-journals" target="">Affiliations for journals</a></li><li><a href="/core/services/publishing-ethics/research-ethics-journals" target="">Research ethics for journals</a></li><li><a href="/core/services/publishing-ethics/competing-interests-and-funding-journals" target="">Competing interests and funding for journals</a></li><!--]--></ol><!--]--><!--[--><li>Journals (cont.)</li><ol><!--[--><li><a href="/core/services/publishing-ethics/data-and-supporting-evidence-for-journals" target="">Data and supporting evidence for journals</a></li><li><a href="/core/services/publishing-ethics/misconduct-journals" target="">Misconduct for journals</a></li><li><a href="/core/services/publishing-ethics/corrections-retractions-and-removals-journals" target="">Corrections, retractions and removals for journals</a></li><li><a href="/core/services/publishing-ethics/versions-and-adaptations-journals" target="">Versions and adaptations for journals</a></li><li><a href="/core/services/publishing-ethics/libel-defamation-and-freedom-of-expression" target="">Libel, defamation and freedom of expression</a></li><li><a href="/core/services/publishing-ethics/business-ethics-journals" target="">Business ethics journals</a></li><!--]--></ol><!--]--><!--[--><li>Books</li><ol><!--[--><li><a href="/core/services/publishing-ethics/publishing-ethics-guidelines-books" target="">Publishing ethics guidelines for books</a></li><li><a href="/core/services/publishing-ethics/core-editorial-policies-books" target="">Core editorial policies for books</a></li><li><a href="/core/services/publishing-ethics/authorship-and-contributorship-books" target="">Authorship and contributorship for books</a></li><li><a href="/core/services/publishing-ethics/affiliations-books" target="">Affiliations for books</a></li><li><a href="/core/services/publishing-ethics/research-ethics-books" target="">Research ethics for books</a></li><li><a href="/core/services/publishing-ethics/competing-interests-and-funding-books" target="">Competing interests and funding for books</a></li><!--]--></ol><!--]--><!--[--><li>Books (cont.)</li><ol><!--[--><li><a href="/core/services/publishing-ethics/data-and-supporting-evidence-books" target="">Data and supporting evidence for books</a></li><li><a href="/core/services/publishing-ethics/misconduct-books" target="">Misconduct for books</a></li><li><a href="/core/services/publishing-ethics/corrections-retractions-and-removals-books" target="">Corrections, retractions and removals for books</a></li><li><a href="/core/services/publishing-ethics/versions-and-adaptations-books" target="">Versions and adaptations for books</a></li><li><a href="/core/services/publishing-ethics/libel-defamation-and-freedom-of-expression" target="">Libel, defamation and freedom of expression</a></li><li><a href="/core/services/publishing-ethics/business-ethics-books" target="">Business ethics books</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Publishing partners</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Publishing partners</li><ol><!--[--><li><a href="/core/services/publishing-partners/publishing-partnerships" target="">Publishing partnerships</a></li><li><a href="/core/services/publishing-partners/partner-books" target="">Partner books</a></li><li><a href="/core/services/publishing-partners/ebook-publishing-partnerships" target="">eBook publishing partnerships</a></li><li><a href="/core/services/publishing-partners/journal-publishing-partnerships" target="">Journal publishing partnerships</a></li><!--]--></ol><!--]--><!--[--><li>Publishing partners (cont.)</li><ol><!--[--><li><a href="/core/services/publishing-partners/journals-publishing" target="">Journals publishing</a></li><li><a href="/core/services/publishing-partners/customer-support" target="">Customer support</a></li><li><a href="/core/services/publishing-partners/membership-services" target="">Membership Services</a></li><li><a href="/core/services/publishing-partners/our-team" target="">Our Team</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Open research</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Open access policies</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Open access policies</li><ol><!--[--><li><a href="/core/services/open-research-policies/open-research" target="">Open research</a></li><li><a href="/core/services/open-research-policies/open-access-policies" target="">Open access policies</a></li><li><a href="/core/services/open-research-policies/cambridge-university-press-and-plan-s" target="">Cambridge University Press and Plan S</a></li><li><a href="/core/services/open-research-policies/text-and-data-mining" target="">Text and data mining</a></li><li><a href="/core/services/open-research-policies/preprint-policy" target="">Preprint policy</a></li><li><a href="/core/services/open-research-policies/social-sharing" target="">Social sharing</a></li><!--]--></ol><!--]--><!--[--><li>Journals</li><ol><!--[--><li><a href="/core/services/open-research-policies/open-access-journals" target="">Open access journals</a></li><li><a href="/core/services/open-research-policies/gold-open-access-journals" target="">Gold Open Access journals</a></li><li><a href="/core/services/open-research-policies/transformative-journals" target="">Transformative journals</a></li><li><a href="/core/services/open-research-policies/green-open-access-policy-for-journals" target="">Green Open Access policy for journals</a></li><li><a href="/core/services/open-research-policies/transparent-pricing-policy-for-journals" target="">Transparent pricing policy for journals</a></li><!--]--></ol><!--]--><!--[--><li>Books and Elements</li><ol><!--[--><li><a href="/core/services/open-research-policies/open-access-books" target="">Open access books</a></li><li><a href="/core/services/open-research-policies/gold-open-access-books" target="">Gold open access books</a></li><li><a href="/core/services/open-research-policies/green-open-access-policy-for-books" target="">Green Open Access policy for books</a></li><li><a href="/core/services/open-research-policies/open-access-elements" target="">Open access Elements</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Open access publishing</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>About open access</li><ol><!--[--><li><a href="/core/services/open-access-publishing/open-research" target="">Open research</a></li><li><a href="/core/services/open-access-publishing/open-access-week" target="">Open Access Week</a></li><li><a href="/core/services/open-access-publishing/open-access" target="">What is open access?</a></li><li><a href="/core/services/open-access-publishing/open-access-glossary" target="">Open access glossary</a></li><li><a href="/core/services/open-access-publishing/open-access-myths" target="">Open access myths</a></li><li><a href="/core/services/open-access-publishing/hybrid-open-access-faqs" target="">Hybrid Open Access FAQs</a></li><li><a href="/core/eligibility-checker" target="">Eligibility checker</a></li><!--]--></ol><!--]--><!--[--><li>Open access resources</li><ol><!--[--><li><a href="/core/services/open-access-publishing/open-access-resources" target="">Open access resources</a></li><li><a href="/core/services/open-access-publishing/benefits-of-open-access" target="">Benefits of open access</a></li><li><a href="/core/services/open-access-publishing/creative-commons-licenses" target="">Creative commons licences</a></li><li><a href="/core/services/open-access-publishing/funder-policies-and-mandates" target="">Funder policies and mandates</a></li><li><a href="/core/services/open-access-publishing/article-type-definitions" target="">Article type definitions</a></li><li><a href="/core/services/open-access-publishing/convert-your-article-to-open-access" target="">Convert your article to Open Access</a></li><li><a href="/core/services/open-access-publishing/open-access-video-resources" target="">Open access video resources</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Open research initiatives</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Research transparency</li><ol><!--[--><li><a href="/core/services/open-research-initiatives/transparency-and-openness" target="">Transparency and openness</a></li><li><a href="/core/services/open-research-initiatives/open-practice-badges" target="">Open Practice Badges</a></li><li><a href="/core/services/open-research-initiatives/oa-organisations-initiatives-and-directories" target="">OA organisations, initiatives & directories</a></li><li><a href="/core/services/open-research-initiatives/registered-reports" target="">Registered Reports</a></li><li><a href="/core/services/open-research-initiatives/annotation-for-transparent-inquiry-ati" target="">Annotation for Transparent Inquiry (ATI)</a></li><!--]--></ol><!--]--><!--[--><li>Journal flips</li><ol><!--[--><li><a href="/core/services/open-research-initiatives/open-access-journal-flips" target="">Open access journal flips</a></li><li><a href="/core/services/open-research-initiatives/oa-journal-flip-faqs" target="">OA Journal Flip FAQs</a></li><!--]--></ol><!--]--><!--[--><li>Flip it Open</li><ol><!--[--><li><a href="/core/services/open-research-initiatives/flip-it-open" target="">Flip it Open</a></li><li><a href="/core/services/open-research-initiatives/flip-it-open-faqs" target="">Flip it Open FAQs</a></li><!--]--></ol><!--]--><!--]--></ol><!--]--><!--[--><li>Open access funding</li><ol><!--[--><!--]--></ol><ol><!--[--><!--[--><li>Open access funding</li><ol><!--[--><li><a href="/core/services/open-access-funding/funding-open-access-publication" target="">Funding open access publication</a></li><li><a href="/core/services/open-access-funding/cambridge-open-equity-initiative" target="">Cambridge Open Equity 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value="3BF83347E5E456DAC34F3FABFC8BBF4E"> <span class="legend">Politics and International Relations</span> <span class="total" data-agg-total-for="3BF83347E5E456DAC34F3FABFC8BBF4E">(48)</span> </label> </div> <div class="checkbox" data-agg-container="E044EF2F61B601378786E9EDA901B2D5"> <label> <input type="checkbox" autocomplete="off" data-agg-option="E044EF2F61B601378786E9EDA901B2D5" data-agg-key-container="productSubject" data-legend="Life Sciences" data-productId="E044EF2F61B601378786E9EDA901B2D5" data-count="44" data-ga-event-action="subject_facet" data-ga-event-label="Life Sciences" data-ga-event-cat="refine_search" data-ga-check-state="true" value="E044EF2F61B601378786E9EDA901B2D5"> <span class="legend">Life Sciences</span> <span class="total" data-agg-total-for="E044EF2F61B601378786E9EDA901B2D5">(44)</span> </label> </div> <div class="checkbox" data-agg-container="66BE42A30172E280FDE64F8EE2F485B0"> <label> <input type="checkbox" autocomplete="off" data-agg-option="66BE42A30172E280FDE64F8EE2F485B0" data-agg-key-container="productSubject" data-legend="History" data-productId="66BE42A30172E280FDE64F8EE2F485B0" data-count="40" data-ga-event-action="subject_facet" data-ga-event-label="History" data-ga-event-cat="refine_search" data-ga-check-state="true" value="66BE42A30172E280FDE64F8EE2F485B0"> <span class="legend">History</span> <span class="total" data-agg-total-for="66BE42A30172E280FDE64F8EE2F485B0">(40)</span> </label> </div> <div class="checkbox" data-agg-container="CAAFC2788C5625FEB794C5E2B4A78E16"> <label> <input type="checkbox" autocomplete="off" data-agg-option="CAAFC2788C5625FEB794C5E2B4A78E16" data-agg-key-container="productSubject" data-legend="Area Studies" data-productId="CAAFC2788C5625FEB794C5E2B4A78E16" data-count="30" data-ga-event-action="subject_facet" data-ga-event-label="Area Studies" data-ga-event-cat="refine_search" data-ga-check-state="true" value="CAAFC2788C5625FEB794C5E2B4A78E16"> <span class="legend">Area Studies</span> <span class="total" data-agg-total-for="CAAFC2788C5625FEB794C5E2B4A78E16">(30)</span> </label> </div> <div class="checkbox" data-agg-container="21B42A72BA3E4CB0E3315E5B1B71B07F"> <label> <input type="checkbox" autocomplete="off" data-agg-option="21B42A72BA3E4CB0E3315E5B1B71B07F" data-agg-key-container="productSubject" data-legend="Psychology" data-productId="21B42A72BA3E4CB0E3315E5B1B71B07F" data-count="30" data-ga-event-action="subject_facet" data-ga-event-label="Psychology" data-ga-event-cat="refine_search" data-ga-check-state="true" value="21B42A72BA3E4CB0E3315E5B1B71B07F"> <span class="legend">Psychology</span> <span class="total" data-agg-total-for="21B42A72BA3E4CB0E3315E5B1B71B07F">(30)</span> </label> </div> <div class="checkbox" data-agg-container="0EDCC0540639B06A5669BDEEF50C4CBE"> <label> <input type="checkbox" autocomplete="off" data-agg-option="0EDCC0540639B06A5669BDEEF50C4CBE" data-agg-key-container="productSubject" data-legend="Management" data-productId="0EDCC0540639B06A5669BDEEF50C4CBE" data-count="26" data-ga-event-action="subject_facet" data-ga-event-label="Management" data-ga-event-cat="refine_search" data-ga-check-state="true" value="0EDCC0540639B06A5669BDEEF50C4CBE"> <span class="legend">Management</span> <span class="total" data-agg-total-for="0EDCC0540639B06A5669BDEEF50C4CBE">(26)</span> </label> </div> <div class="checkbox" data-agg-container="15EA497D52C1FA27DD65B6F765D6533B"> <label> <input type="checkbox" autocomplete="off" data-agg-option="15EA497D52C1FA27DD65B6F765D6533B" data-agg-key-container="productSubject" data-legend="Psychiatry" data-productId="15EA497D52C1FA27DD65B6F765D6533B" data-count="23" data-ga-event-action="subject_facet" data-ga-event-label="Psychiatry" data-ga-event-cat="refine_search" data-ga-check-state="true" value="15EA497D52C1FA27DD65B6F765D6533B"> <span class="legend">Psychiatry</span> <span class="total" data-agg-total-for="15EA497D52C1FA27DD65B6F765D6533B">(23)</span> </label> </div> <div class="checkbox" data-agg-container="FA44491F1F55F917C43E9832715B9DE7"> <label> <input type="checkbox" autocomplete="off" data-agg-option="FA44491F1F55F917C43E9832715B9DE7" data-agg-key-container="productSubject" data-legend="Economics" data-productId="FA44491F1F55F917C43E9832715B9DE7" data-count="17" data-ga-event-action="subject_facet" data-ga-event-label="Economics" data-ga-event-cat="refine_search" data-ga-check-state="true" value="FA44491F1F55F917C43E9832715B9DE7"> <span class="legend">Economics</span> <span class="total" data-agg-total-for="FA44491F1F55F917C43E9832715B9DE7">(17)</span> </label> </div> <div class="checkbox" data-agg-container="970D7555FC359C4DCFF375EE7B055A79"> <label> <input type="checkbox" autocomplete="off" data-agg-option="970D7555FC359C4DCFF375EE7B055A79" data-agg-key-container="productSubject" data-legend="Nutrition" data-productId="970D7555FC359C4DCFF375EE7B055A79" data-count="15" data-ga-event-action="subject_facet" data-ga-event-label="Nutrition" data-ga-event-cat="refine_search" data-ga-check-state="true" value="970D7555FC359C4DCFF375EE7B055A79"> <span class="legend">Nutrition</span> <span class="total" data-agg-total-for="970D7555FC359C4DCFF375EE7B055A79">(15)</span> </label> </div> <div class="checkbox" data-agg-container="CCC62FE56DCC1D050CA1340C1CCF46F5"> <label> <input type="checkbox" autocomplete="off" data-agg-option="CCC62FE56DCC1D050CA1340C1CCF46F5" data-agg-key-container="productSubject" data-legend="Engineering" data-productId="CCC62FE56DCC1D050CA1340C1CCF46F5" data-count="14" data-ga-event-action="subject_facet" data-ga-event-label="Engineering" data-ga-event-cat="refine_search" data-ga-check-state="true" value="CCC62FE56DCC1D050CA1340C1CCF46F5"> <span class="legend">Engineering</span> <span class="total" data-agg-total-for="CCC62FE56DCC1D050CA1340C1CCF46F5">(14)</span> </label> </div> <div class="checkbox" data-agg-container="0E2CD53A93003DF17E52D753F6E90683"> <label> <input type="checkbox" autocomplete="off" data-agg-option="0E2CD53A93003DF17E52D753F6E90683" data-agg-key-container="productSubject" data-legend="Sociology" data-productId="0E2CD53A93003DF17E52D753F6E90683" data-count="14" data-ga-event-action="subject_facet" data-ga-event-label="Sociology" data-ga-event-cat="refine_search" data-ga-check-state="true" value="0E2CD53A93003DF17E52D753F6E90683"> <span class="legend">Sociology</span> <span class="total" data-agg-total-for="0E2CD53A93003DF17E52D753F6E90683">(14)</span> </label> </div> <div class="checkbox" data-agg-container="2E44A5AF2838E017617A26DD79FAEAEE"> <label> <input type="checkbox" autocomplete="off" data-agg-option="2E44A5AF2838E017617A26DD79FAEAEE" data-agg-key-container="productSubject" data-legend="Anthropology" data-productId="2E44A5AF2838E017617A26DD79FAEAEE" data-count="11" data-ga-event-action="subject_facet" data-ga-event-label="Anthropology" data-ga-event-cat="refine_search" data-ga-check-state="true" value="2E44A5AF2838E017617A26DD79FAEAEE"> <span class="legend">Anthropology</span> <span class="total" data-agg-total-for="2E44A5AF2838E017617A26DD79FAEAEE">(11)</span> </label> </div> <div class="checkbox" data-agg-container="DBFB610E9FC5E012C011430C0573CC06"> <label> <input type="checkbox" autocomplete="off" data-agg-option="DBFB610E9FC5E012C011430C0573CC06" data-agg-key-container="productSubject" data-legend="Physics and Astronomy" data-productId="DBFB610E9FC5E012C011430C0573CC06" data-count="10" data-ga-event-action="subject_facet" data-ga-event-label="Physics and Astronomy" data-ga-event-cat="refine_search" data-ga-check-state="true" value="DBFB610E9FC5E012C011430C0573CC06"> <span class="legend">Physics and Astronomy</span> <span class="total" data-agg-total-for="DBFB610E9FC5E012C011430C0573CC06">(10)</span> </label> </div> <div class="checkbox" data-agg-container="63A50B5368A9F97F8AA2D6AB965B5F4C"> <label> <input type="checkbox" autocomplete="off" data-agg-option="63A50B5368A9F97F8AA2D6AB965B5F4C" data-agg-key-container="productSubject" data-legend="Archaeology" data-productId="63A50B5368A9F97F8AA2D6AB965B5F4C" data-count="9" data-ga-event-action="subject_facet" data-ga-event-label="Archaeology" data-ga-event-cat="refine_search" data-ga-check-state="true" value="63A50B5368A9F97F8AA2D6AB965B5F4C"> <span class="legend">Archaeology</span> <span class="total" data-agg-total-for="63A50B5368A9F97F8AA2D6AB965B5F4C">(9)</span> </label> </div> <div class="checkbox" data-agg-container="F470FBF5683D93478C7CAE5A30EF9AE8"> <label> <input type="checkbox" autocomplete="off" data-agg-option="F470FBF5683D93478C7CAE5A30EF9AE8" data-agg-key-container="productSubject" data-legend="Earth and Environmental Sciences" data-productId="F470FBF5683D93478C7CAE5A30EF9AE8" data-count="7" data-ga-event-action="subject_facet" data-ga-event-label="Earth and Environmental Sciences" data-ga-event-cat="refine_search" data-ga-check-state="true" value="F470FBF5683D93478C7CAE5A30EF9AE8"> <span class="legend">Earth and Environmental Sciences</span> <span class="total" data-agg-total-for="F470FBF5683D93478C7CAE5A30EF9AE8">(7)</span> </label> </div> <div class="checkbox" data-agg-container="2D1AC3C0E174F1F1A93F8C7DE19E0FAB"> <label> <input type="checkbox" autocomplete="off" data-agg-option="2D1AC3C0E174F1F1A93F8C7DE19E0FAB" data-agg-key-container="productSubject" data-legend="Philosophy" data-productId="2D1AC3C0E174F1F1A93F8C7DE19E0FAB" data-count="7" data-ga-event-action="subject_facet" data-ga-event-label="Philosophy" data-ga-event-cat="refine_search" data-ga-check-state="true" value="2D1AC3C0E174F1F1A93F8C7DE19E0FAB"> <span class="legend">Philosophy</span> <span class="total" data-agg-total-for="2D1AC3C0E174F1F1A93F8C7DE19E0FAB">(7)</span> </label> </div> <div class="checkbox" data-agg-container="7C9FB6788DD8D7E6696263BC774F4D5B"> <label> <input type="checkbox" autocomplete="off" data-agg-option="7C9FB6788DD8D7E6696263BC774F4D5B" data-agg-key-container="productSubject" data-legend="Law" data-productId="7C9FB6788DD8D7E6696263BC774F4D5B" data-count="5" data-ga-event-action="subject_facet" data-ga-event-label="Law" data-ga-event-cat="refine_search" data-ga-check-state="true" value="7C9FB6788DD8D7E6696263BC774F4D5B"> <span class="legend">Law</span> <span class="total" data-agg-total-for="7C9FB6788DD8D7E6696263BC774F4D5B">(5)</span> </label> </div> <div class="checkbox" data-agg-container="FA1467C44B5BD46BB8AA6E58C2252153"> <label> <input type="checkbox" autocomplete="off" data-agg-option="FA1467C44B5BD46BB8AA6E58C2252153" data-agg-key-container="productSubject" data-legend="Mathematics" data-productId="FA1467C44B5BD46BB8AA6E58C2252153" data-count="5" data-ga-event-action="subject_facet" data-ga-event-label="Mathematics" data-ga-event-cat="refine_search" data-ga-check-state="true" value="FA1467C44B5BD46BB8AA6E58C2252153"> <span class="legend">Mathematics</span> <span class="total" data-agg-total-for="FA1467C44B5BD46BB8AA6E58C2252153">(5)</span> </label> </div> <div class="checkbox" data-agg-container="A370B5604591CB3C7F9AFD892DDF7BD1"> <label> <input type="checkbox" autocomplete="off" data-agg-option="A370B5604591CB3C7F9AFD892DDF7BD1" data-agg-key-container="productSubject" data-legend="Music" data-productId="A370B5604591CB3C7F9AFD892DDF7BD1" data-count="4" data-ga-event-action="subject_facet" data-ga-event-label="Music" data-ga-event-cat="refine_search" data-ga-check-state="true" value="A370B5604591CB3C7F9AFD892DDF7BD1"> <span class="legend">Music</span> <span class="total" data-agg-total-for="A370B5604591CB3C7F9AFD892DDF7BD1">(4)</span> </label> </div> <div class="checkbox" data-agg-container="53E51D24FB488962B9364A2C4B45D1C3"> <label> <input type="checkbox" autocomplete="off" data-agg-option="53E51D24FB488962B9364A2C4B45D1C3" data-agg-key-container="productSubject" data-legend="Religion" data-productId="53E51D24FB488962B9364A2C4B45D1C3" data-count="4" data-ga-event-action="subject_facet" data-ga-event-label="Religion" data-ga-event-cat="refine_search" data-ga-check-state="true" value="53E51D24FB488962B9364A2C4B45D1C3"> <span class="legend">Religion</span> <span class="total" data-agg-total-for="53E51D24FB488962B9364A2C4B45D1C3">(4)</span> </label> </div> </div> </div> </fieldset> <div class="actions" data-search-request-handler="tags"> <div class="filter-title"><label for="keyword-tagInput">Tags</label></div> <div class="columns"> <div class="row"> <div class="row collapse postfix-radius"> <div class="submit-in-field submit-in-field-add clearfix js-outglow-parent"> <div class="small-12 columns"> <div role="status" aria-live="polite" id="announce-result-keyword-search" class="announce-result"></div> <input name="keyword-tagInput" id="keyword-tagInput" type="text" value="" placeholder="Add keyword" class="js-outglow" data-test-id="textboxTags" role="combobox" aria-autocomplete="both" aria-expanded="false" 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</label> </div> <div class="checkbox" data-agg-container="A92395F884342781CC494B063CA2C0F8"> <label> <input type="checkbox" autocomplete="off" data-agg-option="A92395F884342781CC494B063CA2C0F8" data-agg-key-container="productJournal" data-legend="International Psychogeriatrics" data-productId="A92395F884342781CC494B063CA2C0F8" data-count="6" value="A92395F884342781CC494B063CA2C0F8"> <span class="legend">International Psychogeriatrics</span> <span class="total" data-agg-total-for="A92395F884342781CC494B063CA2C0F8">(6)</span> </label> </div> <div class="checkbox" data-agg-container="202D77A6F591FCD2F3F34AEEB8DE334E"> <label> <input type="checkbox" autocomplete="off" data-agg-option="202D77A6F591FCD2F3F34AEEB8DE334E" data-agg-key-container="productJournal" data-legend="Annales. 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class="legend">Developmental Medicine and Child Neurology</span> <span class="total" data-agg-total-for="0C53E71B40997F44440191718C64C45D">(2)</span> </label> </div> <div class="checkbox" data-agg-container="2104B73E1F48DE2DBDAC9CE8222B1F3D"> <label> <input type="checkbox" autocomplete="off" data-agg-option="2104B73E1F48DE2DBDAC9CE8222B1F3D" data-agg-key-container="productJournal" data-legend="Journal of Law, Medicine & Ethics" data-productId="2104B73E1F48DE2DBDAC9CE8222B1F3D" data-count="2" value="2104B73E1F48DE2DBDAC9CE8222B1F3D"> <span class="legend">Journal of Law, Medicine & Ethics</span> <span class="total" data-agg-total-for="2104B73E1F48DE2DBDAC9CE8222B1F3D">(2)</span> </label> </div> <div class="checkbox" data-agg-container="0F454C48ED6F33DE4865103EC60099B0"> <label> <input type="checkbox" autocomplete="off" data-agg-option="0F454C48ED6F33DE4865103EC60099B0" data-agg-key-container="productJournal" data-legend="Palliative & Supportive Care" 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data-ga-check-state="true" value="5CFBF6FDBB6F6DACD38CA89C912D4763"> <span class="legend">International Psychogeriatric Association</span> <span class="total" data-agg-total-for="5CFBF6FDBB6F6DACD38CA89C912D4763">(5)</span> </label> </div> <div class="checkbox" data-agg-container="25CC574B2E469F35EFD974A69B84582F"> <label> <input type="checkbox" autocomplete="off" data-agg-option="25CC574B2E469F35EFD974A69B84582F" data-agg-key-container="productSociety" data-legend="AEPC Association of European Paediatric Cardiology" data-productId="25CC574B2E469F35EFD974A69B84582F" data-count="4" data-ga-event-action="society_facet" data-ga-event-label="AEPC Association of European Paediatric Cardiology" data-ga-event-cat="refine_search" data-ga-check-state="true" value="25CC574B2E469F35EFD974A69B84582F"> <span class="legend">AEPC Association of European Paediatric Cardiology</span> <span class="total" data-agg-total-for="25CC574B2E469F35EFD974A69B84582F">(4)</span> </label> </div> <div 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data-test-title="PP52 Pharmaceutical Innovativeness Index FDA Approved Prostate Cancer Medications 2011 To 2021 A Case Study"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="F0270A38DEA782EAC19CCF88896F842C" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="31112" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"F0270A38DEA782EAC19CCF88896F842C","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/international-journal-of-technology-assessment-in-health-care/article/pp52-pharmaceutical-innovativeness-index-fdaapproved-prostate-cancer-medications-2011-to-2021-a-case-study/F0270A38DEA782EAC19CCF88896F842C"> PP52 Pharmaceutical Innovativeness Index – FDA-Approved Prostate Cancer Medications (2011 To 2021): A Case Study </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Ariane André&eventCode=SE-AU" class="more-by-this-author ">Ariane André</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ludmila Gargano&eventCode=SE-AU" class="more-by-this-author ">Ludmila Gargano</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Isabela Freitas&eventCode=SE-AU" class="more-by-this-author ">Isabela Freitas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Francisco de Assis Acurcio&eventCode=SE-AU" class="more-by-this-author ">Francisco de Assis Acurcio</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Juliana Alvares-Teodoro&eventCode=SE-AU" class="more-by-this-author ">Juliana Alvares-Teodoro</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Augusto Guerra, Jr&eventCode=SE-AU" class="more-by-this-author ">Augusto Guerra, Jr</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="5A33AA41BC24DE8673ABFB7AF1B91C58" href="/core/journals/international-journal-of-technology-assessment-in-health-care">International Journal of Technology Assessment in Health Care</a> / Volume 40 / <a href="/core/product/4248B693F816EEA119A5CBB5D6507FB8" class="productParent" data-prod-id="4248B693F816EEA119A5CBB5D6507FB8">Issue S1</a> / December 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 07 January 2025</span><span class="pages">, p. S76</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-F0270A38DEA782EAC19CCF88896F842C" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/F0270A38DEA782EAC19CCF88896F842C/S026646232400223Xa.pdf/pp52_pharmaceutical_innovativeness_index_fdaapproved_prostate_cancer_medications_2011_to_2021_a_case_study.pdf" data-pdf-content-id="F0270A38DEA782EAC19CCF88896F842C" target="_blank" aria-label="Download PDF for PP52 Pharmaceutical Innovativeness Index – FDA-Approved Prostate Cancer Medications (2011 To 2021): A Case Study [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="F0270A38DEA782EAC19CCF88896F842C" data-container="representation" aria-label="Export citation for PP52 Pharmaceutical Innovativeness Index – FDA-Approved Prostate Cancer Medications (2011 To 2021): A Case Study">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS026646232400223X')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for PP52 Pharmaceutical Innovativeness Index – FDA-Approved Prostate Cancer Medications (2011 To 2021): A Case Study" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"F0270A38DEA782EAC19CCF88896F842C"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS026646232400223X" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Introduction</span><p>Prostate cancer (PC) constitutes 13.5% of all cancer cases globally. Treatment is individualized and depends on various factors. In recent years, there has been an increase in the approval of drugs for the disease by the U.S. Food and Drug Administration (FDA). The study aimed to assess the innovativeness of FDA-approved drugs for PC treatment from 2011 to 2021.</p></div><div class='sec'><span class="bold">Methods</span><p>A search was conducted in the FDA database to identify medications approved from 2011 to 2021 and their supporting studies for approval. The assessment of the value of innovations was performed through the Pharmaceutical Innovativeness Index (PII), a methodology that quantitatively evaluates innovations in four domains: Therapeutic Need and Added Therapeutic Value of the new medication (graded on five levels from important to absent), and Study Design and Methodological Quality (graded on three levels) of the pivotal studies used as a data source for evaluation. Medications are assessed for a specific clinical indication and compared to available therapeutic alternatives.</p></div><div class='sec'><span class="bold">Results</span><p>Seven medications were identified for the treatment of PC, targeting different stages of the disease. The drugs were evaluated with a score ranging from 0 to 100, measuring the degree of innovativeness across the four assessed domains. Five (70%) medications scored above 50.0. The majority of the medications addressed a significant Therapeutic Need (n=4; 56%). The Added Therapeutic Value was assessed based on the survival gain compared to the comparator, with five medications considered poor (70%) and two moderate (30%). Regarding the quality of evidence, most studies showed a low risk of bias and a partially adequate design.</p></div><div class='sec'><span class="bold">Conclusions</span><p>In recent years, there has been an increase in the development of drugs for prostate cancer. However, the Added Therapeutic Value shows a small to moderate increase in survival compared to existing treatments. Many studies used a placebo instead of comparing new medications with available therapies. The PII indicates that, despite advancements, new technologies are needed to improve patient survival.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S026646232400223X" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S026646232400223X" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="70B2ACAEF66B78D00E1776247B3CD117"> <div class="row product-section" data-test-id="searchItem" data-test-title="PD18 Cytomegalovirus Prophylaxis With Valganciclovir For HIV Immunosuppressed Patients Cost Effectiveness And Budget Impact Analysis From The Brazilian Healthcare System Perspective"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="70B2ACAEF66B78D00E1776247B3CD117" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="34595" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"70B2ACAEF66B78D00E1776247B3CD117","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/international-journal-of-technology-assessment-in-health-care/article/pd18-cytomegalovirus-prophylaxis-with-valganciclovir-for-hivimmunosuppressed-patients-cost-effectiveness-and-budget-impact-analysis-from-the-brazilian-healthcare-system-perspective/70B2ACAEF66B78D00E1776247B3CD117"> PD18 Cytomegalovirus Prophylaxis With Valganciclovir For HIV-Immunosuppressed Patients: Cost Effectiveness And Budget Impact Analysis From The Brazilian Healthcare System Perspective </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Ludmila Gargano&eventCode=SE-AU" class="more-by-this-author ">Ludmila Gargano</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane André&eventCode=SE-AU" class="more-by-this-author ">Ariane André</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Isabela Freitas&eventCode=SE-AU" class="more-by-this-author ">Isabela Freitas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Francisco de Assis Acurcio&eventCode=SE-AU" class="more-by-this-author ">Francisco de Assis Acurcio</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Juliana Alvares-Teodoro&eventCode=SE-AU" class="more-by-this-author ">Juliana Alvares-Teodoro</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Augusto Guerra, Jr&eventCode=SE-AU" class="more-by-this-author ">Augusto Guerra, Jr</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="5A33AA41BC24DE8673ABFB7AF1B91C58" href="/core/journals/international-journal-of-technology-assessment-in-health-care">International Journal of Technology Assessment in Health Care</a> / Volume 40 / <a href="/core/product/4248B693F816EEA119A5CBB5D6507FB8" class="productParent" data-prod-id="4248B693F816EEA119A5CBB5D6507FB8">Issue S1</a> / December 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 07 January 2025</span><span class="pages">, p. S104</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-70B2ACAEF66B78D00E1776247B3CD117" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/70B2ACAEF66B78D00E1776247B3CD117/S0266462324002848a.pdf/pd18_cytomegalovirus_prophylaxis_with_valganciclovir_for_hivimmunosuppressed_patients_cost_effectiveness_and_budget_impact_analysis_from_the_brazilian_healthcare_system_perspective.pdf" data-pdf-content-id="70B2ACAEF66B78D00E1776247B3CD117" target="_blank" aria-label="Download PDF for PD18 Cytomegalovirus Prophylaxis With Valganciclovir For HIV-Immunosuppressed Patients: Cost Effectiveness And Budget Impact Analysis From The Brazilian Healthcare System Perspective [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="70B2ACAEF66B78D00E1776247B3CD117" data-container="representation" aria-label="Export citation for PD18 Cytomegalovirus Prophylaxis With Valganciclovir For HIV-Immunosuppressed Patients: Cost Effectiveness And Budget Impact Analysis From The Brazilian Healthcare System Perspective">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0266462324002848')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for PD18 Cytomegalovirus Prophylaxis With Valganciclovir For HIV-Immunosuppressed Patients: Cost Effectiveness And Budget Impact Analysis From The Brazilian Healthcare System Perspective" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"70B2ACAEF66B78D00E1776247B3CD117"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0266462324002848" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Introduction</span><p>Cytomegalovirus (CMV) infections are usually mild but can lead to serious consequences in immunocompromised patients, such as those infected with human immunodeficiency virus (HIV). Valganciclovir, which is approved for treating CMV, may be a cost-effective prophylactic for CMV disease in immunocompromised patients. Cost-effectiveness and budget impact analyses were conducted to compare valganciclovir prophylaxis with no prophylaxis in immunosuppressed patients with HIV.</p></div><div class='sec'><span class="bold">Methods</span><p>Immunosuppressed patients with HIV who were seropositive for CMV were modeled in a one-year horizon decision tree. Outcomes were occurrence of CMV end-organ disease (EOD)–retinitis and gastroenteritis (85 and 15 percent of cases, respectively)–and survival probability after EOD. Direct medical costs related to prophylaxis (induction and maintenance phases) and treatment of EOD were considered. The budget impact analysis (BIA) used the clinical and cost parameters of the cost-effectiveness analysis to compare scenarios with valganciclovir prophylaxis and no prophylaxis in the public health system over a five-year time horizon. The annual market share adoption rate used was 10 percent. The number of eligible patients was calculated from HIV and acquired immunodeficiency syndrome cases reported in the country and epidemiological estimates.</p></div><div class='sec'><span class="bold">Results</span><p>Valganciclovir prophylaxis had an incremental cost of BRL31,781 (USD6,531) and added 0.69 percent in one-year survival, resulting in an incremental cost-effectiveness ratio (ICER) of BRL4,610,022 (USD947,414) per death avoided in one year. The annual budget impact ranged from BRL35,660,931 (USD7,328,743) in the first year to BRL457,707,796 (USD94,064,365) in the fifth year, totaling BRL1,230,400,576 (USD252,861,870) over five years. In sensitivity analyses, the lack of a maximum treatment time for the maintenance phase with valganciclovir (50 to 365 days per year) resulted in a wide variation in the ICER and BIA results.</p></div><div class='sec'><span class="bold">Conclusions</span><p>Despite being recommended for the treatment of CMV retinitis, the use of valganciclovir in immunocompromised patients with HIV who are seropositive for CMV but have not developed CMV disease has a higher ICER when compared with no prophylaxis. For these patients, appropriate use of standard antiretroviral therapy to improve the immune system may be more appropriate.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0266462324002848" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0266462324002848" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="675413587FEF330CFC9AD937B91E1360"> <div class="row product-section" data-test-id="searchItem" data-test-title="OP75 Pharmaceutical Innovativeness Index Evaluation Of Pharmaceutical Innovation In Lung Cancer Treatment Drugs Approved Between 2011 And 2021"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="675413587FEF330CFC9AD937B91E1360" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="31427" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"675413587FEF330CFC9AD937B91E1360","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/international-journal-of-technology-assessment-in-health-care/article/op75-pharmaceutical-innovativeness-index-evaluation-of-pharmaceutical-innovation-in-lung-cancer-treatment-drugs-approved-between-2011-and-2021/675413587FEF330CFC9AD937B91E1360"> OP75 Pharmaceutical Innovativeness Index: Evaluation Of Pharmaceutical Innovation In Lung Cancer Treatment Drugs Approved Between 2011 And 2021 </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Isabela Freitas&eventCode=SE-AU" class="more-by-this-author ">Isabela Freitas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ludmila Gargano&eventCode=SE-AU" class="more-by-this-author ">Ludmila Gargano</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane André&eventCode=SE-AU" class="more-by-this-author ">Ariane André</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Francisco de Assis Acurcio&eventCode=SE-AU" class="more-by-this-author ">Francisco de Assis Acurcio</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Juliana Alvares-Teodoro&eventCode=SE-AU" class="more-by-this-author ">Juliana Alvares-Teodoro</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Augusto Guerra, Jr&eventCode=SE-AU" class="more-by-this-author ">Augusto Guerra, Jr</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="5A33AA41BC24DE8673ABFB7AF1B91C58" href="/core/journals/international-journal-of-technology-assessment-in-health-care">International Journal of Technology Assessment in Health Care</a> / Volume 40 / <a href="/core/product/4248B693F816EEA119A5CBB5D6507FB8" class="productParent" data-prod-id="4248B693F816EEA119A5CBB5D6507FB8">Issue S1</a> / December 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 07 January 2025</span><span class="pages">, p. S33</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-675413587FEF330CFC9AD937B91E1360" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/675413587FEF330CFC9AD937B91E1360/S026646232400134Xa.pdf/op75_pharmaceutical_innovativeness_index_evaluation_of_pharmaceutical_innovation_in_lung_cancer_treatment_drugs_approved_between_2011_and_2021.pdf" data-pdf-content-id="675413587FEF330CFC9AD937B91E1360" target="_blank" aria-label="Download PDF for OP75 Pharmaceutical Innovativeness Index: Evaluation Of Pharmaceutical Innovation In Lung Cancer Treatment Drugs Approved Between 2011 And 2021 [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="675413587FEF330CFC9AD937B91E1360" data-container="representation" aria-label="Export citation for OP75 Pharmaceutical Innovativeness Index: Evaluation Of Pharmaceutical Innovation In Lung Cancer Treatment Drugs Approved Between 2011 And 2021">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS026646232400134X')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for OP75 Pharmaceutical Innovativeness Index: Evaluation Of Pharmaceutical Innovation In Lung Cancer Treatment Drugs Approved Between 2011 And 2021" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"675413587FEF330CFC9AD937B91E1360"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS026646232400134X" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Introduction</span><p>Lung cancer (LC) ranks second globally in neoplasia diagnoses and exhibits the highest oncological mortality rate. Oncology has seen a marked increase in U.S. Food and Drug Administration (FDA) approvals for novel drugs, notably in the case of LC. This study aims to assess the innovativeness of recently FDA-approved LC treatments compared to existing options, spanning the 2011 to 2021 period.</p></div><div class='sec'><span class="bold">Methods</span><p>The innovativeness of drugs was assessed through the Pharmaceutical Innovativeness Index (PII). The methodology considers population health needs and aggregated clinical benefits, while weighing methodological quality and the adequacy of available evidence. New drugs are analyzed considering available therapeutic alternatives. The assessment assigns an innovativeness score to the drugs, with 1.0 representing the highest degree of innovation. PII was applied to all drugs with their first FDA indication for LC treatment. The evaluation considered specific clinical indications (e.g., treatment of ALK-positive LC), and data from FDA clinical review reports and pivotal clinical trials were considered.</p></div><div class='sec'><span class="bold">Results</span><p>Eighteen new drugs were identified during the period. The drugs were evaluated with a mean PII of 0.615, ranging from 0.474 to 0.811. No discernible trends in innovativeness were observed within specific indications. Overall, the evaluations indicated that these medications were approved to address significant therapeutic needs. However, the added therapeutic value ranged from absent to moderate. Most supporting evidence for these approvals was derived from clinical studies with low risk of bias. Nevertheless, these studies often featured inadequate designs due to the absence of a comparator arm, limiting the assessment of added therapeutic value.</p></div><div class='sec'><span class="bold">Conclusions</span><p>Pharmaceutical innovations in recent years for LC treatment have demonstrated limited clinical benefits when compared to existing alternatives, highlighting a substantial therapeutic need. The application of the PII can assist in healthcare decision-making, guide investments and research efforts, as well as inform pricing and reimbursement of new technologies, thereby contributing to the sustainability of healthcare systems.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S026646232400134X" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S026646232400134X" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="0B37C2F23906D66F61C9A9E671034B1A"> <div class="row product-section" data-test-id="searchItem" data-test-title="PP51 Pharmaceutical Innovativeness Index PII A New Framework For Assessing Health Technology Innovation Based On Therapeutic And Social Relevance"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="0B37C2F23906D66F61C9A9E671034B1A" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="34142" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"0B37C2F23906D66F61C9A9E671034B1A","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/international-journal-of-technology-assessment-in-health-care/article/pp51-pharmaceutical-innovativeness-index-pii-a-new-framework-for-assessing-health-technology-innovation-based-on-therapeutic-and-social-relevance/0B37C2F23906D66F61C9A9E671034B1A"> PP51 Pharmaceutical Innovativeness Index (PII): A New Framework For Assessing Health Technology Innovation Based On Therapeutic And Social Relevance </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Ludmila Gargano&eventCode=SE-AU" class="more-by-this-author ">Ludmila Gargano</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane André&eventCode=SE-AU" class="more-by-this-author ">Ariane André</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Isabela Freitas&eventCode=SE-AU" class="more-by-this-author ">Isabela Freitas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Francisco de Assis Acurcio&eventCode=SE-AU" class="more-by-this-author ">Francisco de Assis Acurcio</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Juliana Alvares-Teodoro&eventCode=SE-AU" class="more-by-this-author ">Juliana Alvares-Teodoro</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Augusto Guerra, Jr&eventCode=SE-AU" class="more-by-this-author ">Augusto Guerra, Jr</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="5A33AA41BC24DE8673ABFB7AF1B91C58" href="/core/journals/international-journal-of-technology-assessment-in-health-care">International Journal of Technology Assessment in Health Care</a> / Volume 40 / <a href="/core/product/4248B693F816EEA119A5CBB5D6507FB8" class="productParent" data-prod-id="4248B693F816EEA119A5CBB5D6507FB8">Issue S1</a> / December 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 07 January 2025</span><span class="pages">, p. S75</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-0B37C2F23906D66F61C9A9E671034B1A" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/0B37C2F23906D66F61C9A9E671034B1A/S0266462324002228a.pdf/pp51_pharmaceutical_innovativeness_index_pii_a_new_framework_for_assessing_health_technology_innovation_based_on_therapeutic_and_social_relevance.pdf" data-pdf-content-id="0B37C2F23906D66F61C9A9E671034B1A" target="_blank" aria-label="Download PDF for PP51 Pharmaceutical Innovativeness Index (PII): A New Framework For Assessing Health Technology Innovation Based On Therapeutic And Social Relevance [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="0B37C2F23906D66F61C9A9E671034B1A" data-container="representation" aria-label="Export citation for PP51 Pharmaceutical Innovativeness Index (PII): A New Framework For Assessing Health Technology Innovation Based On Therapeutic And Social Relevance">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0266462324002228')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for PP51 Pharmaceutical Innovativeness Index (PII): A New Framework For Assessing Health Technology Innovation Based On Therapeutic And Social Relevance" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"0B37C2F23906D66F61C9A9E671034B1A"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0266462324002228" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Introduction</span><p>The value of a new pharmaceutical product should rely on its therapeutic benefits while also considering social health needs. Adapting health technology assessment (HTA) tools, we propose a transparent framework, with well-defined criteria and script, to determine the value of innovation (i.e., innovativeness) with clinical and methodological parameters, based on the social relevance and therapeutic value of new medicines.</p></div><div class='sec'><span class="bold">Methods</span><p>The study was developed by adapting HTA-based methods identified in the literature: the Italian Medicines Agency (AIFA) and the EValuation of pharmaceutical Innovations with regard to Therapeutic Advantage (EVITA) tool. A sample of oncology drugs approved by the U.S. Food and Drug Administration (FDA) between 2011 and 2021 were assessed by researchers trained in HTA tools using those methods. After assessing the sample, researchers discussed the results, difficulties, and issues experienced. Those issues were addressed, resulting in the creation of the new framework, which included the redefinition of domains, definition of classification criteria for each domain, and scores according to relevance.</p></div><div class='sec'><span class="bold">Results</span><p>The Pharmaceutical Innovativeness Index (PII) was proposed, with a script, domains, criteria, and an algorithm. The evaluation begins defining indication, outcomes, therapeutic alternatives, time perspective, and data sources. Four domains were considered: Therapeutic Need, which evaluates the existence and benefits of alternatives; Added Therapeutic Value, which talks about the incremental clinical benefit when compared to those alternatives (these first two domains were graded into five levels ranging from absent to maximum); Study Design and Methodological Quality, both classified into three levels. Classification criteria for each domain can be adapted according to the indication and relevant outcomes.</p></div><div class='sec'><span class="bold">Conclusions</span><p>The PII framework considers clinical and social value weighted by methodological limitation of available evidence to determine the value of innovation of pharmaceutical products. It stands out as a transparent, adaptable, and reproducible tool that aims to reduce the subjectivity of analyses and assist with decision-making. PII has the potential to inform decision-making processes involving value-based pricing, reimbursement, and research and development investment.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0266462324002228" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0266462324002228" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="093D7B6DF81866F4BB0ADAC39B014071"> <div class="row product-section" data-test-id="searchItem" data-test-title="PP70 Comparison Of Approval Dates Of New Substances Between The US Food And Drug Administration And The European Medicines Agency"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="093D7B6DF81866F4BB0ADAC39B014071" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="28362" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"093D7B6DF81866F4BB0ADAC39B014071","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/international-journal-of-technology-assessment-in-health-care/article/pp70-comparison-of-approval-dates-of-new-substances-between-the-us-food-and-drug-administration-and-the-european-medicines-agency/093D7B6DF81866F4BB0ADAC39B014071"> PP70 Comparison Of Approval Dates Of New Substances Between The U.S. Food And Drug Administration And The European Medicines Agency </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Ariane Batscheider&eventCode=SE-AU" class="more-by-this-author ">Ariane Batscheider</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Evgeniya Shlaen&eventCode=SE-AU" class="more-by-this-author ">Evgeniya Shlaen</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Katharina Weiß&eventCode=SE-AU" class="more-by-this-author ">Katharina Weiß</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Darya Schnauffer&eventCode=SE-AU" class="more-by-this-author ">Darya Schnauffer</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Roger-Axel Greiner&eventCode=SE-AU" class="more-by-this-author ">Roger-Axel Greiner</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Peter Wagner&eventCode=SE-AU" class="more-by-this-author ">Peter Wagner</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Doreen Bonduelle&eventCode=SE-AU" class="more-by-this-author ">Doreen Bonduelle</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="5A33AA41BC24DE8673ABFB7AF1B91C58" href="/core/journals/international-journal-of-technology-assessment-in-health-care">International Journal of Technology Assessment in Health Care</a> / Volume 40 / <a href="/core/product/4248B693F816EEA119A5CBB5D6507FB8" class="productParent" data-prod-id="4248B693F816EEA119A5CBB5D6507FB8">Issue S1</a> / December 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 07 January 2025</span><span class="pages">, p. S84</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-093D7B6DF81866F4BB0ADAC39B014071" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/093D7B6DF81866F4BB0ADAC39B014071/S026646232400240Xa.pdf/pp70_comparison_of_approval_dates_of_new_substances_between_the_us_food_and_drug_administration_and_the_european_medicines_agency.pdf" data-pdf-content-id="093D7B6DF81866F4BB0ADAC39B014071" target="_blank" aria-label="Download PDF for PP70 Comparison Of Approval Dates Of New Substances Between The U.S. Food And Drug Administration And The European Medicines Agency [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="093D7B6DF81866F4BB0ADAC39B014071" data-container="representation" aria-label="Export citation for PP70 Comparison Of Approval Dates Of New Substances Between The U.S. Food And Drug Administration And The European Medicines Agency">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS026646232400240X')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for PP70 Comparison Of Approval Dates Of New Substances Between The U.S. Food And Drug Administration And The European Medicines Agency" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"093D7B6DF81866F4BB0ADAC39B014071"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS026646232400240X" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Introduction</span><p>Early access to innovative medications is a key factor for the quality of medical care. We investigated differences in approval dates of new active substances between the U.S. and Europe and a potential connection with company headquarter location.</p></div><div class='sec'><span class="bold">Methods</span><p>Data of new active substances (no generics, biosimilars, and hybrids) approved by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) from 1 January 2018 to 29 November 2023 were retrieved from FDA and EMA websites. We calculated the time difference between the drug approval dates between the agencies. We also retrieved the location of the headquarters of pharmaceutical companies.</p></div><div class='sec'><span class="bold">Results</span><p>Since 2018, 390 medicines were approved by FDA or EMA: 113 (29.0%) only by FDA versus 40 (10.3%) only by EMA, and 237 (60.8%) by both. Approval of 32.1 percent of medicines occurred within six months. Fifty-seven percent were approved more than six months earlier by FDA and 11.0 percent more than six months earlier by EMA. Overall, 45.6 percent of the headquarters are in Europe and 44.1 percent are in North America. For medicines approved by FDA only, 63.7 percent of headquarters are in North America and 26.5 percent are in Europe. This is reversed for medicines approved by EMA only. For substances approved by both, 50.6 percent of headquarters are in Europe and 39.2 percent are in North America.</p></div><div class='sec'><span class="bold">Conclusions</span><p>Almost 30 percent of new medicines approved by FDA within the last five years are not yet approved in Europe whereas only 10 percent are approved by EMA only. There is a tendency for companies with headquarters in North America to seek approval from FDA first. For medicines with approval from both authorities, most companies are primarily located in Europe.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S026646232400240X" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S026646232400240X" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="B2FCEBC80AC6334A64A364679D10EEA2"> <div class="row product-section" data-test-id="searchItem" data-test-title="Chapter 10 Prognostication in Status Epilepticus"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="B2FCEBC80AC6334A64A364679D10EEA2" data-prod-source="search" data-prod-type="BOOK_PART" data-file-size="0" data-cup-event-payload='{"eventCode":"DL-BP","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"B2FCEBC80AC6334A64A364679D10EEA2","referringURL":"","authenticationMethods":[],"usedIdentities":[],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/books/neuroprognostication-in-critical-care/prognostication-in-status-epilepticus/B2FCEBC80AC6334A64A364679D10EEA2">Chapter 10 - Prognostication in Status Epilepticus</a></h3></li> <li class="paragraph_05 margin-top-small"> from Part I - Disease-Specific Prognostication </li> <li> <ul> <li class="author chapter"> By <a href="/core/search?filters%5BauthorTerms%5D=Katlyn Nemani&eventCode=SE-AU" class="more-by-this-author"> <span class="author-name">Katlyn Nemani</span></a>, <a href="/core/search?filters%5BauthorTerms%5D=Ariane Lewis&eventCode=SE-AU" class="more-by-this-author"> <span class="author-name">Ariane Lewis</span></a> </li> </ul> </li> <li class="author"> Edited by <a href="/core/search?filters%5BauthorTerms%5D=David M. Greer&eventCode=SE-AU" class="more-by-this-author"><span class="author-name">David M. Greer</span></a>, <span class="affiliation">Boston University School of Medicine and Boston Medical Center</span><span class="separator">,</span> <a href="/core/search?filters%5BauthorTerms%5D=Neha S. Dangayach&eventCode=SE-AU" class="more-by-this-author"><span class="author-name">Neha S. Dangayach</span></a>, <span class="affiliation">Icahn School of Medicine at Mount Sinai and Mount Sinai Health System</span> </li> <li> <dl> <dt class="source dl-inline">Book: </dt> <dd> <a href="/core/books/neuroprognostication-in-critical-care/2CE69CE1B22371E22B65E028718B3D2E" class="url productParent" data-prod-id="2CE69CE1B22371E22B65E028718B3D2E">Neuroprognostication in Critical Care</a> </dd> <dt class="published dl-inline">Published online: </dt> <dd> <span class="date">14 November 2024</span> </dd> <dt class="published dl-inline">Print publication: </dt> <dd> <span class="date">21 November 2024</span>, <span> pp <span class="pages">153-164</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type chapter">Chapter</li> <li> <ul class="access-modal"> <li class="status get"> <a href="#" class="get hasTooltipCustom-top" aria-label="Get access for Chapter 10 - Prognostication in Status Epilepticus" data-qtip-event="click" data-cup-event='{"eventCode":"TA-EX","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"GET","searchScope":"PRODUCT","productId":"B2FCEBC80AC6334A64A364679D10EEA2"}' >Get access</a> <div class="custom-tooltip custom-tooltip--buttons"> <div class="grey-bg"> <div class="row"> <div class="column small-12 text-center tooltip-row">Check if you have access via personal or institutional login</div> </div> <div class="tooltip-row row text-center padding-bottom"> <a href="/core/login?ref=/core/search?filters%5BauthorTerms%5D=Ariane" class="button small radius blue ">Log in</a> <a href="/core/register?ref=/core/search?filters%5BauthorTerms%5D=Ariane" class="button small radius blue ">Register</a> </div> </div> </div> </li> </ul> </li> <li><a href="#" class="export-citation-component" data-prod-id="B2FCEBC80AC6334A64A364679D10EEA2" data-container="representation" aria-label="Export citation for Chapter 10 - Prognostication in Status Epilepticus">Export citation </a></li> </ul> </li> <li class="accordion abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstract-9781108762489_CN-BP-10')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View extract for Chapter 10 - Prognostication in Status Epilepticus" data-cup-event='{"eventCode":"IN-BP","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"B2FCEBC80AC6334A64A364679D10EEA2"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type"> extract </span> </div> </button> <div id="abstract-9781108762489_CN-BP-10" class="content"> <div class="overview"> <div class="description"> <h4 class="heading_10 margin-top">Summary</h4> <div class="summary"> <div class="abstract" data-abstract-type="extract"><p>Status epilepticus (SE) is a neurological emergency with a mortality rate of 20–30%.[1] SE can have long-term consequences such as neuronal death, neuronal injury, and alteration of neuronal networks.[2] Severe neurological or cognitive sequelae have been reported in 11–16% of survivors.[3] The annual direct inpatient cost of SE is estimated to be over $4 billion in the United States.[4]</p><p>There is an estimated global incidence of 12.6 episodes of SE per 100,000 person-years.[5] However, it is worth noting that the definition of the clinical and electrographic findings consistent with SE have changed over time and can vary depending on which definition is being used. Additionally, there are multiple different semiologies of SE. The most commonly accepted definition for convulsive SE is either 5 minutes or more of continuous seizure activity or two or more discrete seizures between which there is incomplete recovery of consciousness.[6]</p></div> </div> </div> </div> </div> </div> </li> </ul> </div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="AE289386A5396E54AE6BA0EBEBC1ACCA"> <div class="row product-section" data-test-id="searchItem" data-test-title="Chapter 21 Religious and Legal Issues in Neuroprognostication"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="AE289386A5396E54AE6BA0EBEBC1ACCA" data-prod-source="search" data-prod-type="BOOK_PART" data-file-size="0" data-cup-event-payload='{"eventCode":"DL-BP","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"AE289386A5396E54AE6BA0EBEBC1ACCA","referringURL":"","authenticationMethods":[],"usedIdentities":[],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/books/neuroprognostication-in-critical-care/religious-and-legal-issues-in-neuroprognostication/AE289386A5396E54AE6BA0EBEBC1ACCA">Chapter 21 - Religious and Legal Issues in Neuroprognostication</a></h3></li> <li class="paragraph_05 margin-top-small"> from Part II - Other Topics in Neuroprognostication </li> <li> <ul> <li class="author chapter"> By <a href="/core/search?filters%5BauthorTerms%5D=Aaron Sylvan Lord&eventCode=SE-AU" class="more-by-this-author"> <span class="author-name">Aaron Sylvan Lord</span></a>, <a href="/core/search?filters%5BauthorTerms%5D=Ariane Lewis&eventCode=SE-AU" class="more-by-this-author"> <span class="author-name">Ariane Lewis</span></a> </li> </ul> </li> <li class="author"> Edited by <a href="/core/search?filters%5BauthorTerms%5D=David M. Greer&eventCode=SE-AU" class="more-by-this-author"><span class="author-name">David M. Greer</span></a>, <span class="affiliation">Boston University School of Medicine and Boston Medical Center</span><span class="separator">,</span> <a href="/core/search?filters%5BauthorTerms%5D=Neha S. Dangayach&eventCode=SE-AU" class="more-by-this-author"><span class="author-name">Neha S. Dangayach</span></a>, <span class="affiliation">Icahn School of Medicine at Mount Sinai and Mount Sinai Health System</span> </li> <li> <dl> <dt class="source dl-inline">Book: </dt> <dd> <a href="/core/books/neuroprognostication-in-critical-care/2CE69CE1B22371E22B65E028718B3D2E" class="url productParent" data-prod-id="2CE69CE1B22371E22B65E028718B3D2E">Neuroprognostication in Critical Care</a> </dd> <dt class="published dl-inline">Published online: </dt> <dd> <span class="date">14 November 2024</span> </dd> <dt class="published dl-inline">Print publication: </dt> <dd> <span class="date">21 November 2024</span>, <span> pp <span class="pages">297-304</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type chapter">Chapter</li> <li> <ul class="access-modal"> <li class="status get"> <a href="#" class="get hasTooltipCustom-top" aria-label="Get access for Chapter 21 - Religious and Legal Issues in Neuroprognostication" data-qtip-event="click" data-cup-event='{"eventCode":"TA-EX","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"GET","searchScope":"PRODUCT","productId":"AE289386A5396E54AE6BA0EBEBC1ACCA"}' >Get access</a> <div class="custom-tooltip custom-tooltip--buttons"> <div class="grey-bg"> <div class="row"> <div class="column small-12 text-center tooltip-row">Check if you have access via personal or institutional login</div> </div> <div class="tooltip-row row text-center padding-bottom"> <a href="/core/login?ref=/core/search?filters%5BauthorTerms%5D=Ariane" class="button small radius blue ">Log in</a> <a href="/core/register?ref=/core/search?filters%5BauthorTerms%5D=Ariane" class="button small radius blue ">Register</a> </div> </div> </div> </li> </ul> </li> <li><a href="#" class="export-citation-component" data-prod-id="AE289386A5396E54AE6BA0EBEBC1ACCA" data-container="representation" aria-label="Export citation for Chapter 21 - Religious and Legal Issues in Neuroprognostication">Export citation </a></li> </ul> </li> <li class="accordion abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstract-9781108762489_CN-BP-21')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View extract for Chapter 21 - Religious and Legal Issues in Neuroprognostication" data-cup-event='{"eventCode":"IN-BP","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"AE289386A5396E54AE6BA0EBEBC1ACCA"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type"> extract </span> </div> </button> <div id="abstract-9781108762489_CN-BP-21" class="content"> <div class="overview"> <div class="description"> <h4 class="heading_10 margin-top">Summary</h4> <div class="summary"> <div class="abstract" data-abstract-type="extract"><p>Of all areas of medicine, the practice of neurological prognostication requires one of the deepest understandings of the humanistic aspects of medicine. Neurological injuries affect the most human aspects of a patient’s life – the ability to think, feel, talk, eat, and walk. The impact of neurological injuries must be considered in the context of a patient’s and their family’s cultural, moral, and religious beliefs. Additionally, a patient’s geographical location influences their case from legal and social perspectives. Neurological prognostication for a severely brain-injured patient is practiced in a very different way by a clinician at a major medical center in New York City caring for an Orthodox Jewish patient than it is by a clinician in Bangladesh caring for a Muslim patient. All neurological prognostication requires an intimate understanding of a patient’s ethical and religious beliefs and the local laws and customs.</p></div> </div> </div> </div> </div> </div> </li> </ul> </div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="3A223F076DF142EFDCE046DD0C2B1984"> <div class="row product-section" data-test-id="searchItem" data-test-title="Introducing medical students to cultural psychiatry perspectives and reflections on developing and delivering an elective module"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="3A223F076DF142EFDCE046DD0C2B1984" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="412970" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"3A223F076DF142EFDCE046DD0C2B1984","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/bjpsych-bulletin/article/introducing-medical-students-to-cultural-psychiatry-perspectives-and-reflections-on-developing-and-delivering-an-elective-module/3A223F076DF142EFDCE046DD0C2B1984"> Introducing medical students to cultural psychiatry: perspectives and reflections on developing and delivering an elective module </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Tahir Jokinen&eventCode=SE-AU" class="more-by-this-author ">Tahir Jokinen</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Nawal Benachar&eventCode=SE-AU" class="more-by-this-author ">Nawal Benachar</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Arian Rahim&eventCode=SE-AU" class="more-by-this-author ">Arian Rahim</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="AE57F2D3347A75B2B13C794FEBB67272" href="/core/journals/bjpsych-bulletin">BJPsych Bulletin</a> , <a href="/core/product/AE57F2D3347A75B2B13C794FEBB67272/firstview">FirstView</a> </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 08 November 2024</span><span class="pages">, pp. 1-5</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have 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aria-expanded="false" aria-label="View Abstract for Introducing medical students to cultural psychiatry: perspectives and reflections on developing and delivering an elective module" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"3A223F076DF142EFDCE046DD0C2B1984"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS2056469424001001" class="content"> <div class="abstract" data-abstract-type="normal"><p>Cultural sensitivity, competence and curiosity are essential for clinicians. To promote these, we developed an elective module in cultural psychiatry for medical students, consisting of eight seminars. In seminar eight, we used film clips to teach mental state examination. We comment on the development and delivery of the module, and offer a selection of student feedback. Cultural psychiatry could be better integrated into core medical school curricula, and we call for research to explore this.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1192/bjb.2024.100" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1192/bjb.2024.100" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="1ACA1B4E09BC11938A284B53F3A2AB70"> <div class="row product-section" data-test-id="searchItem" data-test-title="Extended Delays in Recognition of Stroke Symptoms and Stroke Code Activation for In Hospital Strokes The DELAY Study"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="1ACA1B4E09BC11938A284B53F3A2AB70" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="565994" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"1ACA1B4E09BC11938A284B53F3A2AB70","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/canadian-journal-of-neurological-sciences/article/extended-delays-in-recognition-of-stroke-symptoms-and-stroke-code-activation-for-inhospital-strokes-the-delay-study/1ACA1B4E09BC11938A284B53F3A2AB70"> Extended Delays in Recognition of Stroke Symptoms and Stroke Code Activation for In-Hospital Strokes: The DELAY Study </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Pamela N. Correia&eventCode=SE-AU" class="more-by-this-author ">Pamela N. Correia</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Justine Roy&eventCode=SE-AU" class="more-by-this-author ">Justine Roy</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Claire Haumesser&eventCode=SE-AU" class="more-by-this-author ">Claire Haumesser</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Lahoud Touma&eventCode=SE-AU" class="more-by-this-author ">Lahoud Touma</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Gregory Jacquin&eventCode=SE-AU" class="more-by-this-author ">Gregory Jacquin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alexandre Y. Poppe&eventCode=SE-AU" class="more-by-this-author ">Alexandre Y. Poppe</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Yan Deschaintre&eventCode=SE-AU" class="more-by-this-author ">Yan Deschaintre</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Veilleux Carpentier&eventCode=SE-AU" class="more-by-this-author ">Ariane Veilleux Carpentier</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="A15C3D1075D5ECE8B8BA8069337C929A" href="/core/journals/canadian-journal-of-neurological-sciences">Canadian Journal of Neurological Sciences</a> , <a href="/core/product/A15C3D1075D5ECE8B8BA8069337C929A/firstview">First View</a> </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 04 November 2024</span><span class="pages">, pp. 1-8</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-1ACA1B4E09BC11938A284B53F3A2AB70" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/1ACA1B4E09BC11938A284B53F3A2AB70/S0317167124003044a.pdf/extended_delays_in_recognition_of_stroke_symptoms_and_stroke_code_activation_for_inhospital_strokes_the_delay_study.pdf" data-pdf-content-id="1ACA1B4E09BC11938A284B53F3A2AB70" target="_blank" aria-label="Download PDF for Extended Delays in Recognition of Stroke Symptoms and Stroke Code Activation for In-Hospital Strokes: The DELAY Study [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/1ACA1B4E09BC11938A284B53F3A2AB70/core-reader" target="_blank" aria-label="View HTML full text for Extended Delays in Recognition of Stroke Symptoms and Stroke Code Activation for In-Hospital Strokes: The DELAY Study [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"1ACA1B4E09BC11938A284B53F3A2AB70","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="1ACA1B4E09BC11938A284B53F3A2AB70" data-container="representation" aria-label="Export citation for Extended Delays in Recognition of Stroke Symptoms and Stroke Code Activation for In-Hospital Strokes: The DELAY Study">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0317167124003044')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Extended Delays in Recognition of Stroke Symptoms and Stroke Code Activation for In-Hospital Strokes: The DELAY Study" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"1ACA1B4E09BC11938A284B53F3A2AB70"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0317167124003044" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Patients with stroke while hospitalized experience important delays in symptom recognition. This study aims to describe the overall management of an in-hospital stroke population and how it compares with an out-of-hospital community-onset stroke population.</p></div><div class='sec'><span class="bold">Methods:</span><p>In this retrospective observational study, we included consecutive patients with in-hospital and out-of-hospital strokes (both ischemic and hemorrhagic) over a period of one year treated at a comprehensive stroke center. Demographic and clinical data were extracted, and patient groups were compared with regard to stroke treatment time metrics.</p></div><div class='sec'><span class="bold">Results:</span><p>A total of 362 patients diagnosed with acute stroke were included, of whom 38 (10.5%) had in-hospital and 324 (89.5%) had out-of-hospital strokes. The median delay to stroke recognition (time between the last time seen well and first time seen symptomatic) was significantly longer in in-hospital compared to out-of-hospital strokes (77.5 [0–334.8] vs. 0 [0–138.5] min, <span class='italic'>p</span> = 0.04). The median time interval from stroke code activation to the arrival of the stroke team at the bedside was significantly shorter in in-hospital versus out-of-hospital cases (10 [6–15] vs. 15 [8–24.8] min, <span class='italic'>p</span> = 0.01). In-hospital strokes were less likely to receive thrombolysis (12.8% vs. 45.4%, <span class='italic'>p</span> < 0.01) with significantly higher mortality (18.2% versus 2.6%, <span class='italic'>p</span> < 0.01) and longer overall median hospital stay (3 [1–7] vs. 12 days [7–23], <span class='italic'>p</span> < 0.01) compared to out-of-hospital strokes.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>This study showed significant delays in stroke symptom recognition and stroke code activation for in-hospital stroke patients despite comparable overall stroke time metrics. Development of in-hospital stroke protocols and systematic staff training on stroke symptom recognition should be implemented to improve care for hospitalized patients.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2024.304" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cjn.2024.304" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="CF99BEB620AF61EAEDCF7B360312F994"> <div class="row product-section" data-test-id="searchItem" data-test-title="Measuring loneliness a head to head psychometric comparison of the 3 and 20 item UCLA Loneliness Scales"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="CF99BEB620AF61EAEDCF7B360312F994" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="268163" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"CF99BEB620AF61EAEDCF7B360312F994","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/psychological-medicine/article/measuring-loneliness-a-headtohead-psychometric-comparison-of-the-3-and-20item-ucla-loneliness-scales/CF99BEB620AF61EAEDCF7B360312F994"> Measuring loneliness: a head-to-head psychometric comparison of the 3- and 20-item UCLA Loneliness Scales </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Corentin J. Gosling&eventCode=SE-AU" class="more-by-this-author ">Corentin J. Gosling</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Romain Colle&eventCode=SE-AU" class="more-by-this-author ">Romain Colle</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Cartigny&eventCode=SE-AU" class="more-by-this-author ">Ariane Cartigny</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Fabrice Jollant&eventCode=SE-AU" class="more-by-this-author ">Fabrice Jollant</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Emmanuelle Corruble&eventCode=SE-AU" class="more-by-this-author ">Emmanuelle Corruble</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariel Frajerman&eventCode=SE-AU" class="more-by-this-author ">Ariel Frajerman</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="2E4A9A64B37548F25362F3235C223463" href="/core/journals/psychological-medicine">Psychological Medicine</a> / Volume 54 / <a href="/core/product/64F966D21B9BD32B1E35103B00CB0DF5" class="productParent" data-prod-id="64F966D21B9BD32B1E35103B00CB0DF5">Issue 14</a> / October 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 31 October 2024</span><span class="pages">, pp. 3821-3827</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-CF99BEB620AF61EAEDCF7B360312F994" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/CF99BEB620AF61EAEDCF7B360312F994/S0033291724002083a.pdf/measuring_loneliness_a_headtohead_psychometric_comparison_of_the_3_and_20item_ucla_loneliness_scales.pdf" data-pdf-content-id="CF99BEB620AF61EAEDCF7B360312F994" target="_blank" aria-label="Download PDF for Measuring loneliness: a head-to-head psychometric comparison of the 3- and 20-item UCLA Loneliness Scales [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/CF99BEB620AF61EAEDCF7B360312F994/core-reader" target="_blank" aria-label="View HTML full text for Measuring loneliness: a head-to-head psychometric comparison of the 3- and 20-item UCLA Loneliness Scales [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"CF99BEB620AF61EAEDCF7B360312F994","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="CF99BEB620AF61EAEDCF7B360312F994" data-container="representation" aria-label="Export citation for Measuring loneliness: a head-to-head psychometric comparison of the 3- and 20-item UCLA Loneliness Scales">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0033291724002083')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Measuring loneliness: a head-to-head psychometric comparison of the 3- and 20-item UCLA Loneliness Scales" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"CF99BEB620AF61EAEDCF7B360312F994"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0033291724002083" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background</span><p>Despite the growing interest in the prevalence and consequences of loneliness, the way it is measured still raises a number of questions. In particular, few studies have directly compared the psychometric properties of very short measures of loneliness to standard measures.</p></div><div class='sec'><span class="bold">Methods</span><p>We conducted a large epidemiological study of midwife students (<span class='italic'>n</span> = 1742) and performed a head-to-head comparison of the psychometric properties of the standard (20 items) and short version (3 items) of the UCLA Loneliness Scales (UCLA-LS). All participants completed the UCLA-LS-20, UCLA-LS-3, as well as other measures of mental health, including anxiety and depression.</p></div><div class='sec'><span class="bold">Results</span><p>First, as predicted, we found that the two loneliness scales were strongly associated with each other. Second, when using the dimensional scores of the scales, we showed that the internal reliability, convergent-, discriminant-, and known-groups validities were high and of similar magnitude between the UCLA-LS-20 and the UCLA-LS-3. Third, when the scales were dichotomized, the results were more mixed. The sensitivity and/or specificity of the UCLA-LS-3 against the UCLA-LS-20 were systematically below acceptable thresholds, regardless of the dichotomizing process used. In addition, the prevalence of loneliness was strikingly variable as a function of the cut-offs used.</p></div><div class='sec'><span class="bold">Conclusions</span><p>Overall, we showed that the UCLA-LS-3 provided an adequate dimensional measure of loneliness that is very similar to the UCLA-LS-20. On the other hand, we were able to highlight more marked differences between the scales when their scores were dichotomized, which has important consequences for studies estimating, for example, the prevalence of loneliness.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0033291724002083" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0033291724002083" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="692B6EA88B09D3C3A991FB94A252295B"> <div class="row product-section" data-test-id="searchItem" data-test-title="When and where can coastal wetland restoration increase carbon sequestration as a natural climate solution"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="692B6EA88B09D3C3A991FB94A252295B" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="1492476" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"692B6EA88B09D3C3A991FB94A252295B","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/cambridge-prisms-coastal-futures/article/when-and-where-can-coastal-wetland-restoration-increase-carbon-sequestration-as-a-natural-climate-solution/692B6EA88B09D3C3A991FB94A252295B"> When and where can coastal wetland restoration increase carbon sequestration as a natural climate solution? </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Scott F. Jones&eventCode=SE-AU" class="more-by-this-author ">Scott F. Jones</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Arias-Ortiz&eventCode=SE-AU" class="more-by-this-author ">Ariane Arias-Ortiz</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Dennis Baldocchi&eventCode=SE-AU" class="more-by-this-author ">Dennis Baldocchi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Meagan Eagle&eventCode=SE-AU" class="more-by-this-author ">Meagan Eagle</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Daniel A. Friess&eventCode=SE-AU" class="more-by-this-author ">Daniel A. Friess</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Catrina Gore&eventCode=SE-AU" class="more-by-this-author ">Catrina Gore</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Greg Noe&eventCode=SE-AU" class="more-by-this-author ">Greg Noe</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Stefanie Nolte&eventCode=SE-AU" class="more-by-this-author ">Stefanie Nolte</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Patty Oikawa&eventCode=SE-AU" class="more-by-this-author ">Patty Oikawa</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Adina Paytan&eventCode=SE-AU" class="more-by-this-author ">Adina Paytan</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jacqueline L. Raw&eventCode=SE-AU" class="more-by-this-author ">Jacqueline L. Raw</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Brian J. Roberts&eventCode=SE-AU" class="more-by-this-author ">Brian J. Roberts</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kerrylee Rogers&eventCode=SE-AU" class="more-by-this-author ">Kerrylee Rogers</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Charles Schutte&eventCode=SE-AU" class="more-by-this-author ">Charles Schutte</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Camille L. Stagg&eventCode=SE-AU" class="more-by-this-author ">Camille L. Stagg</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Karen M. Thorne&eventCode=SE-AU" class="more-by-this-author ">Karen M. Thorne</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Eric J. Ward&eventCode=SE-AU" class="more-by-this-author ">Eric J. Ward</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Lisamarie Windham-Myers&eventCode=SE-AU" class="more-by-this-author ">Lisamarie Windham-Myers</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Erik S. Yando&eventCode=SE-AU" class="more-by-this-author ">Erik S. Yando</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="9CC038B1592D95311CC63CB43FC02B0F" href="/core/journals/cambridge-prisms-coastal-futures">Cambridge Prisms: Coastal Futures</a> / <a href="/core/product/14BD8C243BCA17FDE5CDB4131315C143" class="productParent" data-prod-id="14BD8C243BCA17FDE5CDB4131315C143">Volume 2</a> / 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 11 October 2024</span><span class="pages">, e13</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-692B6EA88B09D3C3A991FB94A252295B" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/692B6EA88B09D3C3A991FB94A252295B/S2754720524000143a.pdf/when_and_where_can_coastal_wetland_restoration_increase_carbon_sequestration_as_a_natural_climate_solution.pdf" data-pdf-content-id="692B6EA88B09D3C3A991FB94A252295B" target="_blank" aria-label="Download PDF for When and where can coastal wetland restoration increase carbon sequestration as a natural climate solution? [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/692B6EA88B09D3C3A991FB94A252295B/core-reader" target="_blank" aria-label="View HTML full text for When and where can coastal wetland restoration increase carbon sequestration as a natural climate solution? [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"692B6EA88B09D3C3A991FB94A252295B","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="692B6EA88B09D3C3A991FB94A252295B" data-container="representation" aria-label="Export citation for When and where can coastal wetland restoration increase carbon sequestration as a natural climate solution?">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS2754720524000143')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for When and where can coastal wetland restoration increase carbon sequestration as a natural climate solution?" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"692B6EA88B09D3C3A991FB94A252295B"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS2754720524000143" class="content"> <div class="abstract" data-abstract-type="normal"><p>Coastal wetlands are hotspots of carbon sequestration, and their conservation and restoration can help to mitigate climate change. However, there remains uncertainty on when and where coastal wetland restoration can most effectively act as natural climate solutions (NCS). Here, we synthesize current understanding to illustrate the requirements for coastal wetland restoration to benefit climate, and discuss potential paths forward that address key uncertainties impeding implementation. To be effective as NCS, coastal wetland restoration projects will accrue climate cooling benefits that would not occur without management action (additionality), will be implementable (feasibility) and will persist over management-relevant timeframes (permanence). Several issues add uncertainty to understanding if these minimum requirements are met. First, coastal wetlands serve as both a landscape source and sink of carbon for other habitats, increasing uncertainty in additionality. Second, coastal wetlands can potentially migrate outside of project footprints as they respond to sea-level rise, increasing uncertainty in permanence. To address these first two issues, a system-wide approach may be necessary, rather than basing cooling benefits only on changes that occur within project boundaries. Third, the need for NCS to function over management-relevant decadal timescales means methane responses may be necessary to include in coastal wetland restoration planning and monitoring. Finally, there is uncertainty on how much data are required to justify restoration action. We summarize the minimum data required to make a binary decision on whether there is a net cooling benefit from a management action, noting that these data are more readily available than the data required to quantify the magnitude of cooling benefits for carbon crediting purposes. By reducing uncertainty, coastal wetland restoration can be implemented at the scale required to significantly contribute to addressing the current climate crisis.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cft.2024.14" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cft.2024.14" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="E8BADAA1634A3747122B195154A750ED"> <div class="row product-section" data-test-id="searchItem" data-test-title="What do health professionals think about implementing psilocybin assisted therapy in palliative care for existential distress A World Caf qualitative study"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="E8BADAA1634A3747122B195154A750ED" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="29532" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"E8BADAA1634A3747122B195154A750ED","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/palliative-and-supportive-care/article/what-do-health-professionals-think-about-implementing-psilocybinassisted-therapy-in-palliative-care-for-existential-distress-a-world-cafe-qualitative-study/E8BADAA1634A3747122B195154A750ED"> What do health professionals think about implementing psilocybin-assisted therapy in palliative care for existential distress? A World Café qualitative study </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Marianne Masse-Grenier&eventCode=SE-AU" class="more-by-this-author ">Marianne Masse-Grenier</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sue-Ling Chang&eventCode=SE-AU" class="more-by-this-author ">Sue-Ling Chang</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Bélanger&eventCode=SE-AU" class="more-by-this-author ">Ariane Bélanger</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jean-François Stephan&eventCode=SE-AU" class="more-by-this-author ">Jean-François Stephan</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Johanne Hébert&eventCode=SE-AU" class="more-by-this-author ">Johanne Hébert</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Pierre Deschamps&eventCode=SE-AU" class="more-by-this-author ">Pierre Deschamps</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Louis Plourde&eventCode=SE-AU" class="more-by-this-author ">Louis Plourde</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=François Provost&eventCode=SE-AU" class="more-by-this-author ">François Provost</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Houman Farzin&eventCode=SE-AU" class="more-by-this-author ">Houman Farzin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jean-Sébastien Fallu&eventCode=SE-AU" class="more-by-this-author ">Jean-Sébastien Fallu</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michel Dorval&eventCode=SE-AU" class="more-by-this-author ">Michel Dorval</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=P3A Research Group&eventCode=SE-AU" class="more-by-this-author ">P3A Research Group</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="0F454C48ED6F33DE4865103EC60099B0" href="/core/journals/palliative-and-supportive-care">Palliative & Supportive Care</a> / Volume 22 / <a href="/core/product/5315E604A9D0CC8C2D4AE750D0895147" class="productParent" data-prod-id="5315E604A9D0CC8C2D4AE750D0895147">Issue 5</a> / October 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 09 October 2024</span><span class="pages">, pp. 1395-1405</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-E8BADAA1634A3747122B195154A750ED" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/E8BADAA1634A3747122B195154A750ED/S1478951524001494a.pdf/what_do_health_professionals_think_about_implementing_psilocybinassisted_therapy_in_palliative_care_for_existential_distress_a_world_cafe_qualitative_study.pdf" data-pdf-content-id="E8BADAA1634A3747122B195154A750ED" target="_blank" aria-label="Download PDF for What do health professionals think about implementing psilocybin-assisted therapy in palliative care for existential distress? 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A World Café qualitative study [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"E8BADAA1634A3747122B195154A750ED","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="E8BADAA1634A3747122B195154A750ED" data-container="representation" aria-label="Export citation for What do health professionals think about implementing psilocybin-assisted therapy in palliative care for existential distress? A World Café qualitative study">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS1478951524001494')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for What do health professionals think about implementing psilocybin-assisted therapy in palliative care for existential distress? A World Café qualitative study" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"E8BADAA1634A3747122B195154A750ED"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS1478951524001494" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Objectives</span><p>Promising studies show that psilocybin-assisted therapy relieves existential distress in patients with serious illnesses, a difficult condition to treat with current treatment options. There is growing interest in this therapy in palliative care. Canada recently amended its laws to allow physicians to request psilocybin for end-of-life distress. However, barriers to access remain. Since implementing psilocybin-assisted therapy within palliative care depends on the attitudes of healthcare providers willing to recommend it, they should be actively engaged in the broader discussion about this treatment option. We aimed (1) to identify issues and concerns regarding the acceptability of this therapy among palliative care professionals and to discuss ways of remedying them and (2) to identify factors that may facilitate access.</p></div><div class='sec'><span class="bold">Methods</span><p>A qualitative study design and World Café methodology were adopted to collect data. The event was held on April 24, 2023, with 16 palliative care professionals. The data was analyzed following an inductive approach.</p></div><div class='sec'><span class="bold">Results</span><p>Although participants were interested in psilocybin-assisted therapy, several concerns and needs were identified. Educational and certified training needs, medical legalization of psilocybin, more research, refinement of therapy protocols, reflections on the type of professionals dispensing the therapy, the treatment venue, and eligibility criteria for treatment were discussed.</p></div><div class='sec'><span class="bold">Significance of results</span><p>Palliative care professionals consider psilocybin-assisted therapy a treatment of interest, but it generates several concerns. According to our results, the acceptability of the therapy and the expansion of its access seem interrelated. The development of guidelines will be essential to encourage wider therapy deployment.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S1478951524001494" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S1478951524001494" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="AFBA86154393BD740269D2E1005D955B"> <div class="row product-section" data-test-id="searchItem" data-test-title="Overuse of familiar phrases by individuals with Williams syndrome masks differences in language processing"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="AFBA86154393BD740269D2E1005D955B" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="297358" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"AFBA86154393BD740269D2E1005D955B","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/journal-of-child-language/article/overuse-of-familiar-phrases-by-individuals-with-williams-syndrome-masks-differences-in-language-processing/AFBA86154393BD740269D2E1005D955B"> Overuse of familiar phrases by individuals with Williams syndrome masks differences in language processing </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Ioana Sederias&eventCode=SE-AU" class="more-by-this-author ">Ioana Sederias</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Krakovitch&eventCode=SE-AU" class="more-by-this-author ">Ariane Krakovitch</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Vesna Stojanovik&eventCode=SE-AU" class="more-by-this-author ">Vesna Stojanovik</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Vitor C. Zimmerer&eventCode=SE-AU" class="more-by-this-author ">Vitor C. Zimmerer</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="C644EF3F5D5C03A3B735A52482A810B8" href="/core/journals/journal-of-child-language">Journal of Child Language</a> , <a href="/core/product/C644EF3F5D5C03A3B735A52482A810B8/firstview">First View</a> </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 27 September 2024</span><span class="pages">, pp. 1-15</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-AFBA86154393BD740269D2E1005D955B" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/AFBA86154393BD740269D2E1005D955B/S0305000924000436a.pdf/overuse_of_familiar_phrases_by_individuals_with_williams_syndrome_masks_differences_in_language_processing.pdf" data-pdf-content-id="AFBA86154393BD740269D2E1005D955B" target="_blank" aria-label="Download PDF for Overuse of familiar phrases by individuals with Williams syndrome masks differences in language processing [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/AFBA86154393BD740269D2E1005D955B/core-reader" target="_blank" aria-label="View HTML full text for Overuse of familiar phrases by individuals with Williams syndrome masks differences in language processing [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"AFBA86154393BD740269D2E1005D955B","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="AFBA86154393BD740269D2E1005D955B" data-container="representation" aria-label="Export citation for Overuse of familiar phrases by individuals with Williams syndrome masks differences in language processing">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0305000924000436')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Overuse of familiar phrases by individuals with Williams syndrome masks differences in language processing" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"AFBA86154393BD740269D2E1005D955B"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0305000924000436" class="content"> <div class="abstract" data-abstract-type="normal"><p>We investigated whether individuals with Williams Syndrome (WS) produce language with a bias towards statistical properties of word combinations rather than grammatical rules, resulting in an overuse of holistically stored, familiar phrases. We analysed continuous speech samples from English children with WS (n = 12), typically developing (TD) controls matched on chronological age (n = 15) and TD controls matched on language age (n = 14). Alongside word count, utterance length, grammatical complexity, and morphosyntactic errors, we measured familiarity of expressions by computing collocation strength of each word combination. The WS group produced stronger collocations than both control groups. Moreover, the WS group produced fewer complex sentences, shorter utterances, and more frequent function words than chronological-age matched controls. Language in WS may appear more typical than it is because familiar, holistically processed expressions mask grammatical and other difficulties.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0305000924000436" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0305000924000436" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="549CC85E597610672C5201E88332A257"> <div class="row product-section" data-test-id="searchItem" data-test-title="Cacti in distress how to enhance ex situ conservation strategies through living collections"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="549CC85E597610672C5201E88332A257" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="183340" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"549CC85E597610672C5201E88332A257","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/oryx/article/cacti-in-distress-how-to-enhance-ex-situ-conservation-strategies-through-living-collections/549CC85E597610672C5201E88332A257"> Cacti in distress: how to enhance ex situ conservation strategies through living collections </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Thaís Moreira Hidalgo de Almeida&eventCode=SE-AU" class="more-by-this-author ">Thaís Moreira Hidalgo de Almeida</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Diego Rafael Gonzaga&eventCode=SE-AU" class="more-by-this-author ">Diego Rafael Gonzaga</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Luna Peixoto&eventCode=SE-AU" class="more-by-this-author ">Ariane Luna Peixoto</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="22AE0F73FC80F46221D4F9BD1D2B9A27" href="/core/journals/oryx">Oryx</a> / Volume 58 / <a href="/core/product/71413F5CB86C0495F3354D8ADF21E9B7" class="productParent" data-prod-id="71413F5CB86C0495F3354D8ADF21E9B7">Issue 5</a> / September 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 17 October 2024</span><span class="pages">, pp. 565-575</span> </dd> <dt class="published dl-inline">Print publication: </dt> <dd> <span class="date"> September 2024</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-549CC85E597610672C5201E88332A257" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status 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data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"549CC85E597610672C5201E88332A257","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="549CC85E597610672C5201E88332A257" data-container="representation" aria-label="Export citation for Cacti in distress: how to enhance ex situ conservation strategies through living collections">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0030605324000012')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Cacti in distress: how to enhance ex situ conservation strategies through living collections" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"549CC85E597610672C5201E88332A257"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle 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data-abstract-type="normal"><p>Living plant collections play a crucial role in ex situ conservation, but their conservation value hinges on assessment of their composition, data quality and on strategic planning for optimization of the collection that takes into account species diversity, conservation status and allocation of resources. Cactaceae is one of the most threatened plant families globally and has a broad distribution in Brazil, with two of the seven centres of diversity for this group and a total of 276 known species. Climate change could escalate the threat to cacti, potentially placing 90% of species at risk by 2050. We conducted a case study of Cactaceae in the living Cactarium collection of the Rio de Janeiro Botanic Garden, evaluating the diversity of the collection and recommending strategic actions to enhance its conservation value. In 2022, we inventoried all specimens in the collection and cross-referenced them with the institutional specimen registry system, Jabot. The collection contains 156 cacti species that naturally occur in Brazil (57% of the total), including 43 species categorized as threatened on the Brazilian Red List and 57 categorized as threatened on the IUCN Red List. We recommend research to map cacti species that are threatened but not covered by in situ conservation in the country, list the priority species for acquisition by the collection, and make recommendations that will facilitate improved contribution of the Rio de Janeiro Botanic Garden to the conservation of the Brazilian flora.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0030605324000012" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S0030605324000012" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="13515AB4251D26C4194A9F5FFD65E6F5"> <div class="row product-section" 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href="/core/journals/organised-sound/article/sound-image-and-motion-teaching-with-an-interdisciplinary-approach/13515AB4251D26C4194A9F5FFD65E6F5"> Sound, Image and Motion: Teaching with an interdisciplinary approach </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Ariane de Souza Stolfi&eventCode=SE-AU" class="more-by-this-author ">Ariane de Souza Stolfi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Daniel Fils Puig&eventCode=SE-AU" class="more-by-this-author ">Daniel Fils Puig</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Deivison Chioke&eventCode=SE-AU" class="more-by-this-author ">Deivison Chioke</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Júlio César Pereira Carvalho&eventCode=SE-AU" class="more-by-this-author ">Júlio César Pereira Carvalho</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="F662F87343B7F7B98D1E3A6E5A1B21E1" href="/core/journals/organised-sound">Organised Sound</a> / Volume 29 / <a href="/core/product/6BC3CFB6D52E9DDE9EC8A9F187DEF263" class="productParent" data-prod-id="6BC3CFB6D52E9DDE9EC8A9F187DEF263">Issue 2</a> / August 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 25 October 2024</span><span class="pages">, pp. 197-210</span> </dd> <dt class="published dl-inline">Print publication: </dt> <dd> <span class="date"> August 2024</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg 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data-prod-id="13515AB4251D26C4194A9F5FFD65E6F5" data-container="representation" aria-label="Export citation for Sound, Image and Motion: Teaching with an interdisciplinary approach">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS1355771824000116')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Sound, Image and Motion: Teaching with an interdisciplinary approach" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"13515AB4251D26C4194A9F5FFD65E6F5"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS1355771824000116" class="content"> <div class="abstract" data-abstract-type="normal"><p>‘Sound, Image and Motion’ (SIM) is a unique interdisciplinary programme in Brazilian higher education, blending visual arts, audiovisual and sound creation. We start with a brief historical overview of avant-garde traditions in Bahia and delve into the university’s principles and guiding plan in order to situate SIM among art courses and its available resources. We explore its flexible curriculum in detail, considering the limitations posed by a new university with scarce resources, and describe the curricular structure to analyse experiences with teaching and constructing an interdisciplinary sound creation qualification within this programme.</p></div> </div> </div> </li> </ul> </div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="960B1D0EC96B492E0AFDA088CEB949E0"> <div class="row product-section" data-test-id="searchItem" data-test-title="The Dogs of Tsenacomoco Ancient DNA Reveals the Presence of Local Dogs at Jamestown Colony in the Early Seventeenth Century"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="960B1D0EC96B492E0AFDA088CEB949E0" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="30907" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"960B1D0EC96B492E0AFDA088CEB949E0","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/american-antiquity/article/dogs-of-tsenacomoco-ancient-dna-reveals-the-presence-of-local-dogs-at-jamestown-colony-in-the-early-seventeenth-century/960B1D0EC96B492E0AFDA088CEB949E0"> The Dogs of Tsenacomoco: Ancient DNA Reveals the Presence of Local Dogs at Jamestown Colony in the Early Seventeenth Century </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Ariane E. Thomas&eventCode=SE-AU" class="more-by-this-author ">Ariane E. Thomas</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Matthew E. Hill, Jr.&eventCode=SE-AU" class="more-by-this-author ">Matthew E. Hill, Jr.</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Leah Stricker&eventCode=SE-AU" class="more-by-this-author ">Leah Stricker</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Michael Lavin&eventCode=SE-AU" class="more-by-this-author ">Michael Lavin</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=David Givens&eventCode=SE-AU" class="more-by-this-author ">David Givens</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Alida de Flamingh&eventCode=SE-AU" class="more-by-this-author ">Alida de Flamingh</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kelsey E. Witt&eventCode=SE-AU" class="more-by-this-author ">Kelsey E. Witt</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ripan S. Malhi&eventCode=SE-AU" class="more-by-this-author ">Ripan S. Malhi</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Andrew Kitchen&eventCode=SE-AU" class="more-by-this-author ">Andrew Kitchen</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="39C024C90F1E1F43BC0F4648DEE586CB" href="/core/journals/american-antiquity">American Antiquity</a> / Volume 89 / <a href="/core/product/10A565BC0DB8FA7E4589DACDEC0CCC1E" class="productParent" data-prod-id="10A565BC0DB8FA7E4589DACDEC0CCC1E">Issue 3</a> / July 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 22 May 2024</span><span class="pages">, pp. 341-359</span> </dd> <dt class="published dl-inline">Print publication: </dt> <dd> <span class="date"> July 2024</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-960B1D0EC96B492E0AFDA088CEB949E0" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/960B1D0EC96B492E0AFDA088CEB949E0/S0002731624000258a.pdf/dogs_of_tsenacomoco_ancient_dna_reveals_the_presence_of_local_dogs_at_jamestown_colony_in_the_early_seventeenth_century.pdf" data-pdf-content-id="960B1D0EC96B492E0AFDA088CEB949E0" target="_blank" aria-label="Download PDF for The Dogs of Tsenacomoco: Ancient DNA Reveals the Presence of Local Dogs at Jamestown Colony in the Early Seventeenth Century [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/960B1D0EC96B492E0AFDA088CEB949E0/core-reader" target="_blank" aria-label="View HTML full text for The Dogs of Tsenacomoco: Ancient DNA Reveals the Presence of Local Dogs at Jamestown Colony in the Early Seventeenth Century [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"960B1D0EC96B492E0AFDA088CEB949E0","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="960B1D0EC96B492E0AFDA088CEB949E0" data-container="representation" aria-label="Export citation for The Dogs of Tsenacomoco: Ancient DNA Reveals the Presence of Local Dogs at Jamestown Colony in the Early Seventeenth Century">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS0002731624000258')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for The Dogs of Tsenacomoco: Ancient DNA Reveals the Presence of Local Dogs at Jamestown Colony in the Early Seventeenth Century" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"960B1D0EC96B492E0AFDA088CEB949E0"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0002731624000258" class="content"> <div class="abstract" data-abstract-type="normal"><p>Multiple studies have demonstrated that European colonization of the Americas led to the death of nearly all North American dog mitochondrial lineages and replacement with European ones sometime between AD 1492 and the present day. Historical records indicate that colonists imported dogs from Europe to North America, where they became objects of interest and exchange as early as the seventeenth century. However, it is not clear whether the earliest archaeological dogs recovered from colonial contexts were of European, Indigenous, or mixed descent. To clarify the ancestry of dogs from the Jamestown Colony, Virginia, we sequenced ancient mitochondrial DNA from six archaeological dogs from the period 1609–1617. Our analysis shows that the Jamestown dogs have maternal lineages most closely associated with those of ancient Indigenous dogs of North America. Furthermore, these maternal lineages cluster with dogs from Late Woodland, Hopewell, and Virginia Algonquian archaeological sites. Our recovery of Indigenous dog lineages from a European colonial site suggests a complex social history of dogs at the interface of Indigenous and European populations during the early colonial period.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/aaq.2024.25" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/aaq.2024.25" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="C4EBE503424C8CDD7E8DEAEA07BC192F"> <div class="row product-section" data-test-id="searchItem" data-test-title="Implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="C4EBE503424C8CDD7E8DEAEA07BC192F" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="2372006" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"C4EBE503424C8CDD7E8DEAEA07BC192F","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/cardiology-in-the-young/article/implementation-of-the-international-consortium-of-health-outcomes-measurement-chd-standard-set-in-patients-undergoing-pulmonary-valve-replacement/C4EBE503424C8CDD7E8DEAEA07BC192F"> Implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Kevin Hummel&eventCode=SE-AU" class="more-by-this-author ">Kevin Hummel</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Michelson&eventCode=SE-AU" class="more-by-this-author ">Ariane Michelson</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Rachel Zmora&eventCode=SE-AU" class="more-by-this-author ">Rachel Zmora</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sarah de Ferranti&eventCode=SE-AU" class="more-by-this-author ">Sarah de Ferranti</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kathy Jenkins&eventCode=SE-AU" class="more-by-this-author ">Kathy Jenkins</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Susan F. Saleeb&eventCode=SE-AU" class="more-by-this-author ">Susan F. Saleeb</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="3F4E3F4B54523178E350E4A0F944362E" href="/core/journals/cardiology-in-the-young">Cardiology in the Young</a> / Volume 34 / <a href="/core/product/401767CA80C007298F82F9C0256EB75B" class="productParent" data-prod-id="401767CA80C007298F82F9C0256EB75B">Issue 8</a> / August 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 07 May 2024</span><span class="pages">, pp. 1787-1792</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-C4EBE503424C8CDD7E8DEAEA07BC192F" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/C4EBE503424C8CDD7E8DEAEA07BC192F/S1047951124000866a.pdf/implementation_of_the_international_consortium_of_health_outcomes_measurement_chd_standard_set_in_patients_undergoing_pulmonary_valve_replacement.pdf" data-pdf-content-id="C4EBE503424C8CDD7E8DEAEA07BC192F" target="_blank" aria-label="Download PDF for Implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <a href="/core/product/C4EBE503424C8CDD7E8DEAEA07BC192F/core-reader" target="_blank" aria-label="View HTML full text for Implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement [Opens in a new window]" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"C4EBE503424C8CDD7E8DEAEA07BC192F","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}'> <span class="icon icn html wide"> <span class="download-label">HTML</span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="C4EBE503424C8CDD7E8DEAEA07BC192F" data-container="representation" aria-label="Export citation for Implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS1047951124000866')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for Implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"C4EBE503424C8CDD7E8DEAEA07BC192F"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS1047951124000866" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Background:</span><p>Despite the burden of CHD, a high cost and utilization condition, an implementation of long-term outcome measures is lacking. The objective of this study is to pilot the implementation of the International Consortium of Health Outcomes Measurement CHD standard set in patients undergoing pulmonary valve replacement, a procedure performed in mostly well patients with diverse CHD.</p></div><div class='sec'><span class="bold">Methods:</span><p>Patients ≥ 8 years old undergoing catheterization-based pulmonary valve replacement were approached via various approaches for patient-reported outcomes, with a follow-up assessment at 3 months post-procedure. Implementation strategy analysis was performed via a hybrid type 2 design.</p></div><div class='sec'><span class="bold">Results:</span><p>Of the 74 patients undergoing pulmonary valve replacement, 32 completed initial patient-reported outcomes with variable response rates by strategy (email and in-person explanation 100%, email only 54%, and email followed by text/call 64%). Ages ranged 8–67 years (mean 30). Pre-procedurally, 34% had symptomatic arrhythmias, which improved post-procedure. For those in school, 43% missed ≥ 6 days per year, and over half had work absenteeism. Financial concerns were reported in 34%. Patients reported high satisfaction with life (50% [n = 16]) and health-related quality of life (90% [n = 26]). Depression symptoms were reported in 84% (n = 27) and anxiety in 62.5% (n = 18), with tendency towards improvement post-procedurally.</p></div><div class='sec'><span class="bold">Conclusion:</span><p>Pilot implementation of the International Consortium of Health Outcomes Measurement CHD standard set in pulmonary valve replacement patients reveals a significant burden of disease not previously reported. Barriers to the implementation include a sustainable, automated system for patient-reported outcome collection and infrastructure to assess in real time. This provides an example of implementing cardiac outcomes set in clinical practice.</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S1047951124000866" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/S1047951124000866" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="625179B3FC0741A0C5FF98DB80FFBE43"> <div class="row product-section" data-test-id="searchItem" data-test-title="Leveraging capacity for transformative sustainability science a theory of change from the Future Earth Pathways Initiative"> <div class="small-1 columns checklist-col"> <label 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href="/core/journals/global-sustainability/article/leveraging-capacity-for-transformative-sustainability-science-a-theory-of-change-from-the-future-earth-pathways-initiative/625179B3FC0741A0C5FF98DB80FFBE43"> Leveraging capacity for transformative sustainability science: a theory of change from the Future Earth Pathways Initiative </a></h3></li> <li> Part of <ul class="partOfCollection"> <li><a href="/core/product/identifier/CHARTING_THE_COURSE_FOR_THE_NEXT_DECADE_OF/type/BESPOKE_COLLECTION" class="">Charting the Course for the Next Decade of Sustainability Research and Innovation</a></li> </ul> </li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Gilles Marciniak&eventCode=SE-AU" class="more-by-this-author ">Gilles Marciniak</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Davnah Urbach&eventCode=SE-AU" class="more-by-this-author ">Davnah Urbach</a><span class="separator">, </span><a 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Leveraging capacity for transformative sustainability science: a theory of change from the Future Earth Pathways Initiative" data-cup-event='{"eventCode":"IN-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","usedIdentities":[],"authenticationMethods":[],"referringURL":"","eventType":"VADE","searchScope":"PRODUCT","productId":"625179B3FC0741A0C5FF98DB80FFBE43"}' data-cup-event-disable-on-hide="true" > <div class="icon open-drawer small"> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 17 17" class="is-opened"> <circle fill="#696969" cx="8.5" cy="8.5" r="7.5"/> <circle fill="#FFF" cx="8.5" cy="8.5" r="7"/> <path fill="#696969" d="M12.6 7.3H4.4c-.8 0-1.4.5-1.4 1.2s.6 1.2 1.4 1.2h8.3c.8 0 1.4-.5 1.4-1.2-.1-.7-.7-1.2-1.5-1.2z"/> </svg> <svg xmlns="http://www.w3.org/2000/svg" width="15" height="15" viewBox="0 0 15 15" class="is-closed"> <g transform="translate(1 1)" fill="none" fill-rule="evenodd"> <circle fill="#696969" cx="6.5" cy="6.5" r="6.5"/> <circle fill="#FFF" cx="6.5" cy="6.5" r="6"/> <path d="M9.855 5.518H7.482V3.145C7.482 2.491 7.072 2 6.5 2c-.573 0-.982.49-.982 1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS205947982400019X" class="content"> <div class="abstract" data-abstract-type="normal"><div class='sec'><span class="bold">Non-technical summary</span><p>To address increasingly pressing social–environmental challenges, the transformative strand of sustainability science seeks to move beyond a descriptive-analytical stance in order to explore and contribute to the implementation of radical alternatives to dominant and unsustainable paradigms, norms, and values. However, in many cases, academia is not currently structured to support and reward inter-/trans-disciplinary and transformative endeavors. This paper introduces a theory of change for the Future Earth Pathways Initiative, and similar initiatives, to help leverage the capacity of sustainability scientists to engage in transformative research.</p></div><div class='sec'><span class="bold">Technical summary</span><p>The increasing body of descriptive-analytical knowledge produced by sustainability science over the last two decades has largely failed to trigger the transformation of policies, norms, and behaviors it was aiming to inform. The emergent transformative strand of sustainability science is a proactive alternative approach seeking to play an active role in processes of societal change by developing knowledge about options, solutions, and pathways, and by participating in their implementation. In principle, scientists can enhance their contribution to more sustainable futures by engaging in transformative research. However, a lack of skills and competencies, relatively unmatured transformative methods and concepts, and an institutional landscape still geared toward disciplinary and descriptive-analytical research, still hinders the sustainability science community from engaging more widely in transformative research. In this paper, the Future Earth Pathways Initiative introduces a theory of change (ToC) for increasing the capacity of sustainability scientists to engage in this type of research. This ToC ultimately aims to build a growing community of practitioners engaged in transformative research, to advance concepts, methods, and paradigms to foster ‘fit-for-purpose transformative research’, and to shape institutions to nurture transformative research-friendly contexts.</p></div><div class='sec'><span class="bold">Social media summary</span><p>What would a theory of change for leveraging the transformative capacity of sustainability science look like?</p></div></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/sus.2024.19" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/sus.2024.19" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="9BBEA2A6A233B2F7F3C1B790E90A88F8"> <div class="row product-section" data-test-id="searchItem" data-test-title="Estimation of the number of tree species in French Guiana by extrapolation of permanent plots richness"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="9BBEA2A6A233B2F7F3C1B790E90A88F8" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="111154" data-has-entitlement="true" data-has-pdf="true" data-cup-event-payload='{"eventCode":"DL-AR","eventContext":"/core/search?filters[authorTerms]=Ariane","productId":"9BBEA2A6A233B2F7F3C1B790E90A88F8","referringURL":"","authenticationMethods":[],"usedIdentities":["0"],"searchScope":"PRODUCT"}' /> </label> </div> <div class="small-11 columns"> <div class="row"> <!-- listing item --> <div class="product-listing-with-inputs-content"> <div class="small-10 columns margin-bottom left-content-max-width"> <ul class="details"> <li class="title"><h3><a class="part-link" href="/core/journals/journal-of-tropical-ecology/article/estimation-of-the-number-of-tree-species-in-french-guiana-by-extrapolation-of-permanent-plots-richness/9BBEA2A6A233B2F7F3C1B790E90A88F8"> Estimation of the number of tree species in French Guiana by extrapolation of permanent plots richness </a></h3></li> <li></li> <li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Eric Marcon&eventCode=SE-AU" class="more-by-this-author ">Eric Marcon</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Mirabel&eventCode=SE-AU" class="more-by-this-author ">Ariane Mirabel</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jean-François Molino&eventCode=SE-AU" class="more-by-this-author ">Jean-François Molino</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Daniel Sabatier&eventCode=SE-AU" class="more-by-this-author ">Daniel Sabatier</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="37E612587650A3197D3AD4D17AFC9573" href="/core/journals/journal-of-tropical-ecology">Journal of Tropical Ecology</a> / <a href="/core/product/B6617FEFA56F336B53509E9624E64250" class="productParent" data-prod-id="B6617FEFA56F336B53509E9624E64250">Volume 40</a> / 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 05 April 2024</span><span class="pages">, e11</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon 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1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS0266467424000099" class="content"> <div class="abstract" data-abstract-type="normal"><p>The biodiversity of tropical rainforest is difficult to assess. Yet, its estimation is necessary for conservation purposes, to evaluate our level of knowledge and the risks faced by the forest in relation to global change. Our contribution is to estimate the regional richness of tree species from local but widely spread inventories. We reviewed the methods available, which are nonparametric estimators based on abundance or occurrence data, log-series extrapolation and the universal species–area relationship based on maximum entropy. Appropriate methods depend on the scale considered. Harte’s self-similarity model is suitable at the regional scale, while the log-series extrapolation is not. GuyaDiv is a network of forest plots installed over the whole territory of French Guiana, where trees over 10 cm DBH are identified. We used its information (1315 species censused in 68 one-hectare plots) to estimate the exponent of the species–area relationship, assuming Arrhenius’s power law. We could then extrapolate the number of species from three local, wide inventories (over 2.5 km<span class='sup'>2</span>). We evaluated the number of tree species around 2200 over the territory.</p></div> </div> </div> </li> </ul> </div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="representation overview search" data-prod-id="670E8F7FA7D9E8B63D1867E86ED4F478"> <div class="row product-section" data-test-id="searchItem" data-test-title="255 The Community Research Liaison Model Facilitating community engaged research"> <div class="small-1 columns checklist-col"> <label class="product-listing-with-inputs-input"> <input type="checkbox" name="productParts" style="display: inline-block" data-prod-id="670E8F7FA7D9E8B63D1867E86ED4F478" data-prod-source="search" data-prod-type="JOURNAL_ARTICLE" data-file-size="42278" data-has-entitlement="true" data-has-pdf="true" 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<li class="author"> <a href="/core/search?filters%5BauthorTerms%5D=Christina Jäderholm&eventCode=SE-AU" class="more-by-this-author ">Christina Jäderholm</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jessica Currier&eventCode=SE-AU" class="more-by-this-author ">Jessica Currier</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Kim Brown&eventCode=SE-AU" class="more-by-this-author ">Kim Brown</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Ariane Audett&eventCode=SE-AU" class="more-by-this-author ">Ariane Audett</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Laura Campbell&eventCode=SE-AU" class="more-by-this-author ">Laura Campbell</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Steven Blakesley&eventCode=SE-AU" class="more-by-this-author ">Steven Blakesley</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Lynda Crocker Daniel&eventCode=SE-AU" class="more-by-this-author ">Lynda Crocker Daniel</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sylvia Miller&eventCode=SE-AU" class="more-by-this-author ">Sylvia Miller</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Sara Mishalanie&eventCode=SE-AU" class="more-by-this-author ">Sara Mishalanie</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Chelsea Ruder&eventCode=SE-AU" class="more-by-this-author ">Chelsea Ruder</a><span class="separator">, </span><a href="/core/search?filters%5BauthorTerms%5D=Jackilen Shannon&eventCode=SE-AU" class="more-by-this-author ">Jackilen Shannon</a> </li> <li> <dl> <dt class="source dl-inline">Journal: </dt> <dd> <a class="productParent" data-prod-id="DA75B38A644D7326C2D81430A10A06D8" href="/core/journals/journal-of-clinical-and-translational-science">Journal of Clinical and Translational Science</a> / Volume 8 / <a href="/core/product/0B6417D28039F9E820EF9290E8010272" class="productParent" data-prod-id="0B6417D28039F9E820EF9290E8010272">Issue s1</a> / April 2024 </dd> <dt class="published dl-inline">Published online by Cambridge University Press: </dt> <dd> <span class="date"> 03 April 2024</span><span class="pages">, p. 77</span> </dd> </dl> </li> <li> <ul class="access links"> <li class="type article">Article</li> <li> <ul class="access-modal"> <li class="status entitled"> <span class="sr-only">You have access </span> <span class="entitled status-text" title="You have access to this product" aria-hidden="true">Access</span> <span class="icon access-icon cursorDefault" title="You have access to this product" aria-hidden="true"> <svg id="access-670E8F7FA7D9E8B63D1867E86ED4F478" xmlns="http://www.w3.org/2000/svg" viewBox="-701.2 242.7 206.9 328.3"> <circle class="st0" fill="#229619" cx="-597.9" cy="413.8" r="102.5"/> <path class="st1" fill="#fff" d="M-616 472.4l-49.6-49.6 26.5-26.5 23.1 23 59.3-59.3 26.5 26.5z"/> </svg> </span> </li> <li class="status open-access"> <span class="icon access open-access cursorDefault"></span>Open access </li> </ul> </li> <li> <a href="/core/services/aop-cambridge-core/content/view/670E8F7FA7D9E8B63D1867E86ED4F478/S2059866124002334a.pdf/255_the_community_research_liaison_model_facilitating_communityengaged_research.pdf" data-pdf-content-id="670E8F7FA7D9E8B63D1867E86ED4F478" target="_blank" aria-label="Download PDF for 255 The Community Research Liaison Model: Facilitating community-engaged research [Opens in a new window]" > <span class="icon icn pdf"> <span class="download-label">PDF </span> </span> </a> </li> <li> <script> $(document).ready(function () { /** * Disable tooltip aria label attributes, so the screen reader can correctly read out the core * reader tab navigation. * Set a short delay, so we can be sure the tooltips have rendered, before updating the DOM. */ setTimeout(function () { var $downloadLinks = $('.download-types li a'); if ($downloadLinks.length) { $downloadLinks.attr('role', 'tab'); $downloadLinks.attr('aria-describedby', ''); // Remove the aria alerts on the tool tips $('.qtip').attr('role', 'none'); } }, 500); }); </script> </li> <li><a href="#" class="export-citation-component" data-prod-id="670E8F7FA7D9E8B63D1867E86ED4F478" data-container="representation" aria-label="Export citation for 255 The Community Research Liaison Model: Facilitating community-engaged research">Export citation </a></li> </ul> </li> <li class="accordion no-margin-top abstract" data-accordion> <div class="accordion-navigation"> <button onclick="toggleViewHide(this, 'abstractS2059866124002334')" class="button-no-transition transparent-no-border" aria-expanded="false" aria-label="View Abstract for 255 The Community Research Liaison Model: Facilitating community-engaged research" 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1.145V5.518H3.145C2.491 5.518 2 5.928 2 6.5c0 .573.49.982 1.145.982H5.518v2.372c0 .655.41 1.146.982 1.146.573 0 .982-.49.982-1.145V7.482h2.372c.655 0 1.146-.41 1.146-.982 0-.573-.49-.982-1.145-.982z" fill="#696969"/> </g> </svg> <span class="toggle-text">View </span> <span class="excerpt-type">abstract</span> </div> </button> <div id="abstractS2059866124002334" class="content"> <div class="abstract" data-abstract-type="normal"><p>OBJECTIVES/GOALS: The Community Research Liaison Model (CRLM) is a novel model to facilitate community engaged research (CEnR) and community–academic research partnerships focused on health priorities identified by the community. We describe the CRLM development process and how it is operationalized today. METHODS/STUDY POPULATION: The CRLM, informed by the Principles of Community Engagement, builds trust among rural communities and expands capacity for community and investigator-initiated research. We followed a multi-phase process to design and implement a community engagement model that could be replicated. The resulting CRLM moves community–academic research collaborations from objectives to outputs using a conceptual framework that specifies our guiding principles, objectives, and actions to facilitate the objectives (i.e., capacity, motivations, and partners), and outputs. RESULTS/ANTICIPATED RESULTS: The CRLM has been fully implemented across Oregon. Six Community Research Liaisons collectively support 18 predominantly rural Oregon counties. Since 2017, the liaison team has engaged with communities on nearly 300 community projects. The CRLM has been successful in facilitating CEnR and community–academic research partnerships. The model has always existed on a dynamic foundation and continues to be responsive to the lessons learned by the community and researchers. The model is expanding across Oregon as an equitable approach to addressing health disparities across the state. DISCUSSION/SIGNIFICANCE: Our CRLM is based on the idea that community partnerships build research capacity at the community level and are the backbone for pursuing equitable solutions and better health for communities we serve. Our model is unique in its use of CRLs to facilitate community–academic partnerships; this model has brought successes and challenges over the years.</p></div> </div> </div> </li> </ul> </div> <div class="small-6 medium-1 large-1 right hide-for-small altmetric-embed altmetric-core-desktop" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cts.2024.233" data-link-target="_blank"></div> <div class="small-6 columns right text-center hide-for-medium-up altmetric-embed altmetric-core-mobile" data-badge-type='donut' data-hide-less-than="1" data-doi="10.1017/cts.2024.233" data-link-target="_blank"></div> </div> <!-- /listing item --> </div> </div> </div> </div> <hr /> <div class="pagination-centered" data-test-id="paginationSearchResult"> <p class="paragraph_05 margin-bottom-small">Page 1 of 13</p> <ul class="pagination"> <li class="unavailable"><span class="in-active-item">First</span></li> <li class="unavailable"><span class="in-active-item">« Prev</span></li> <li 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