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hentry" itemtype="https://schema.org/CreativeWork" itemscope=""> <div class="entry-content entry-content-servises "> <h1>Determinaton of the Maximum Tolerated Dose</h1> <div class="text-mit-bild-text"> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__items"> <p>The identification of the Maximum-Tolerated Dose (MTD) is one of the first steps when taking a drug candidate from in vitro to in vivo phase of drug discovery. <span lang="EN-AU" xml:lang="EN-AU">The MTD is the dose at which a certain degree of toxicity specified in advance occurs only in a pre-determined tolerable proportion of the animals.</span></p> <p>The frequency and the route of administration play a role in the MTD as well as the mouse strain and the sex. 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