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href="https://es.wikipedia.org/wiki/Interleucina-17" title="Interleucina-17 – Spanish" lang="es" hreflang="es" data-title="Interleucina-17" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%DB%8C%D9%86%D8%AA%D8%B1%D9%84%D9%88%DA%A9%DB%8C%D9%86_%DB%B1%DB%B7" title="اینترلوکین ۱۷ – Persian" lang="fa" hreflang="fa" data-title="اینترلوکین ۱۷" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Interleukine_17" title="Interleukine 17 – French" lang="fr" hreflang="fr" data-title="Interleukine 17" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Interleucina_17" title="Interleucina 17 – Galician" lang="gl" hreflang="gl" data-title="Interleucina 17" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Interleuchina_17" title="Interleuchina 17 – Italian" lang="it" hreflang="it" data-title="Interleuchina 17" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A4%E3%83%B3%E3%82%BF%E3%83%BC%E3%83%AD%E3%82%A4%E3%82%AD%E3%83%B3-17" title="インターロイキン-17 – Japanese" lang="ja" hreflang="ja" data-title="インターロイキン-17" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_17" title="Interleukina 17 – Polish" lang="pl" hreflang="pl" data-title="Interleukina 17" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interleucina_17" title="Interleucina 17 – Portuguese" lang="pt" hreflang="pt" data-title="Interleucina 17" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_17" title="Интерлеукин 17 – Serbian" lang="sr" hreflang="sr" data-title="Интерлеукин 17" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Interleukin_17" title="Interleukin 17 – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Interleukin 17" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E7%99%BD%E7%BB%86%E8%83%9E%E4%BB%8B%E7%B4%A0-17" title="白细胞介素-17 – Chinese" lang="zh" hreflang="zh" data-title="白细胞介素-17" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a 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class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button 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data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">This article is about the protein family. For its founding member, see <a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a>.</div> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein family</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Interleukin 17 family</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd; color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit;">Symbol</th><td class="infobox-data" style="background-color: #eee; color:inherit;">IL-17_fam</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit;"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee; color:inherit;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF06083">PF06083</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit;"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee; color:inherit;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR010345">IPR010345</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee; color:inherit;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd; color:inherit;">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF06083?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF06083">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF06083%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF06083">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF06083">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF06083">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above"><a href="/wiki/IL17A" class="mw-redirect" title="IL17A">Interleukin 17A</a></th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">IL17, CTLA8</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=3605&rn=1">3605</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5981">5981</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/603149">603149</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_002181">NP_002181</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q16552">Q16552</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_6_(human)" class="mw-redirect" title="Chromosome 6 (human)">Chr. 6</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=6p12">p12</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q16552">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q16552">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Interleukin 17B</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">IL17B</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">ZCOTO7</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=27190&rn=1">27190</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5982">5982</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/604627">604627</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_055258">NP_055258</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9UHF5">Q9UHF5</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_5_(human)" class="mw-redirect" title="Chromosome 5 (human)">Chr. 5</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=5q32-34">q32-34</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q9UHF5">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q9UHF5">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Interleukin 17C</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">IL17C</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">CX2</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=27189&rn=1">27189</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5983">5983</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/604628">604628</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_037410">NP_037410</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9P0M4">Q9P0M4</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_16_(human)" class="mw-redirect" title="Chromosome 16 (human)">Chr. 16</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=16q24">q24</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q9P0M4">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q9P0M4">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Interleukin 17D</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">IL17D</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=53342&rn=1">53342</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5984">5984</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/607587">607587</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_612141">NP_612141</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q8TAD2">Q8TAD2</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_13_(human)" class="mw-redirect" title="Chromosome 13 (human)">Chr. 13</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=13q11">q11</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q8TAD2">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q8TAD2">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Interleukin 17E</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">IL17E</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Interleukin_25" title="Interleukin 25">IL-25</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=64806&rn=1">64806</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13765">13765</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/605658">605658</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_073626">NP_073626</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9H293">Q9H293</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_14_(human)" class="mw-redirect" title="Chromosome 14 (human)">Chr. 14</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=14q11.2">q11.2</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q9H293">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q9H293">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Interleukin 17F</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:IL17F_1JPY.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/IL17F_1JPY.png/220px-IL17F_1JPY.png" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f9/IL17F_1JPY.png/330px-IL17F_1JPY.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f9/IL17F_1JPY.png/440px-IL17F_1JPY.png 2x" data-file-width="960" data-file-height="720" /></a></span><div class="infobox-caption"><a href="/wiki/X-ray_crystallography#Biological_macromolecular_crystallography" title="X-ray crystallography">Crystallographic structure</a> of dimeric human IL-17f.<sup id="cite_ref-pmid11574464_1-0" class="reference"><a href="#cite_note-pmid11574464-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Symbol</th><td class="infobox-data" style="background-color: #eee">IL17F</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3">Alt. symbols</th><td class="infobox-data" style="background-color: #eee">ML-1</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/National_Center_for_Biotechnology_Information#Gene" title="National Center for Biotechnology Information">NCBI gene</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&list_uids=112744&rn=1">112744</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/HUGO_Gene_Nomenclature_Committee" title="HUGO Gene Nomenclature Committee">HGNC</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16404">16404</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://omim.org/entry/606496">606496</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JPY">1JPY</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/RefSeq" title="RefSeq">RefSeq</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/protein/NP_443104">NP_443104</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Swiss-Prot" class="mw-redirect" title="Swiss-Prot">UniProt</a></th><td class="infobox-data" style="background-color: #eee"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q96PD4">Q96PD4</a></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Other data</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Locus</a></th><td class="infobox-data" style="background-color: #eee"><a href="/wiki/Chromosome_6_(human)" class="mw-redirect" title="Chromosome 6 (human)">Chr. 6</a> <i><a rel="nofollow" class="external text" href="https://omim.org/search/?index=geneMap&search=6p12">p12</a></i></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546"><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd">Search for</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Structures</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://swissmodel.expasy.org/repository/uniprot/Q96PD4">Swiss-model</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; border:#fafafa 2px solid; border-width:3px 2px 0 0;">Domains</th><td class="infobox-data" style="background-color: #eee; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/protein/Q96PD4">InterPro</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Interleukin 17 family</b> (<b>IL17 family</b>) is a family of pro-inflammatory <a href="/wiki/Cystine_knot" title="Cystine knot">cystine knot</a> <a href="/wiki/Cytokine" title="Cytokine">cytokines</a>.<sup id="cite_ref-Moseley_2003_2-0" class="reference"><a href="#cite_note-Moseley_2003-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> They are produced by a group of <a href="/wiki/T-helper_cells" class="mw-redirect" title="T-helper cells">T helper cell</a> known as <a href="/wiki/Th17_cells" class="mw-redirect" title="Th17 cells">T helper 17 cell</a> in response to their stimulation with <a href="/wiki/Interleukin_23" title="Interleukin 23">IL-23</a>. Originally, Th17 was identified in 1993 by Rouvier <i>et al.</i> who isolated IL17A <a href="/wiki/Transcription_(genetics)" class="mw-redirect" title="Transcription (genetics)">transcript</a> from a <a href="/wiki/Rodent" title="Rodent">rodent</a> <a href="/wiki/T-cell" class="mw-redirect" title="T-cell">T-cell</a> <a href="/wiki/Hybridoma" class="mw-redirect" title="Hybridoma">hybridoma</a>.<sup id="cite_ref-pmid19016708_3-0" class="reference"><a href="#cite_note-pmid19016708-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> The protein encoded by <i>IL17A</i> is a founding member of <a href="/wiki/IL-17_family" class="mw-redirect" title="IL-17 family">IL-17 family</a> (see below). IL17A protein exhibits a high homology with a viral IL-17-like protein (<span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O40633">O40633</a></span>) encoded in the genome of T-lymphotropic <a href="/wiki/Rhadinovirus" title="Rhadinovirus">rhadinovirus</a> <i><a href="/wiki/Herpesvirus_saimiri" class="mw-redirect" title="Herpesvirus saimiri">Herpesvirus saimiri</a></i>. In rodents, IL-17A is often referred to as CTLA8.<sup id="cite_ref-pmid8390535_4-0" class="reference"><a href="#cite_note-pmid8390535-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> </p><p>The biologically active IL-17 interacts with type I cell surface receptor <a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL-17R</a>. In turn, there are at least three variants of IL-17R referred to as <a href="/wiki/IL17RA" title="IL17RA">IL17RA</a>, <a href="/wiki/IL17RB" title="IL17RB">IL17RB</a>, and <a href="/wiki/IL17RC" title="IL17RC">IL17RC</a>.<sup id="cite_ref-pmid12097364_5-0" class="reference"><a href="#cite_note-pmid12097364-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of <a href="/wiki/Chemokines" class="mw-redirect" title="Chemokines">chemokines</a>. Acting as chemoattractants, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, the signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with <a href="/wiki/Tumor_necrosis_factor" title="Tumor necrosis factor">tumor necrosis factor</a> and <a href="/wiki/Interleukin-1" class="mw-redirect" title="Interleukin-1">interleukin-1</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19710487_7-0" class="reference"><a href="#cite_note-pmid19710487-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Moreover, an activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as <a href="/wiki/Psoriasis" title="Psoriasis">psoriasis</a>.<sup id="cite_ref-Martin_2013_8-0" class="reference"><a href="#cite_note-Martin_2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Family_members">Family members</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=1" title="Edit section: Family members"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The IL-17 family in humans comprises <a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a> (sometimes confusingly called "IL-17"), <a href="/w/index.php?title=IL17B&action=edit&redlink=1" class="new" title="IL17B (page does not exist)">IL17B</a>, <a href="/w/index.php?title=IL17C&action=edit&redlink=1" class="new" title="IL17C (page does not exist)">IL17C</a>, <a href="/w/index.php?title=IL17D&action=edit&redlink=1" class="new" title="IL17D (page does not exist)">IL17D</a>, <a href="/wiki/IL17E" class="mw-redirect" title="IL17E">IL17E</a> and <a href="/wiki/IL17F" class="mw-redirect" title="IL17F">IL17F</a>. IL-17E is also known as <a href="/wiki/Interleukin_25" title="Interleukin 25">IL-25</a>. All members of the IL-17 family have a similar <a href="/wiki/Protein" title="Protein">protein</a> structure. Their protein sequences contain four highly conserved <a href="/wiki/Cysteine" title="Cysteine">cysteine</a> residues. These conserved cysteine residues are critical to the right <a href="/wiki/Three-dimensional_space" title="Three-dimensional space">3-dimensional</a> shape of the entire protein molecule. To the reference, the members of the IL-17 family do not exhibit a significant sequence homology with other cytokines. Among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest sequence homology with IL-17A (55 and 40%, respectively). They follow by IL-17B, which has 29% similarity to IL-17A, IL-17D (25%), IL-17C (23%), and IL-17E (17%). In <a href="/wiki/Mammal" title="Mammal">mammals</a>, the sequences of these cytokines are highly conserved. For instance, the sequence homology between the corresponding human and mouse proteins is usually between 62–88%.<sup id="cite_ref-Kolls2004_9-0" class="reference"><a href="#cite_note-Kolls2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Numerous immune regulatory functions have been reported for the IL-17 family of cytokines, presumably due to their induction of many immune signaling molecules. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with allergic responses. IL-17 induces the production of many other cytokines (such as <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a>, <a href="/wiki/G-CSF" class="mw-redirect" title="G-CSF">G-CSF</a>, <a href="/wiki/GM-CSF" class="mw-redirect" title="GM-CSF">GM-CSF</a>, <a href="/wiki/Interleukin-1" class="mw-redirect" title="Interleukin-1">IL-1β</a>, <a href="/wiki/TGF-%CE%B2" class="mw-redirect" title="TGF-β">TGF-β</a>, <a href="/wiki/TNF-%CE%B1" class="mw-redirect" title="TNF-α">TNF-α</a>), <a href="/wiki/Chemokines" class="mw-redirect" title="Chemokines">chemokines</a> (including <a href="/wiki/Interleukin_8" title="Interleukin 8">IL-8</a>, GRO-α, and MCP-1), and <a href="/wiki/Prostaglandins" class="mw-redirect" title="Prostaglandins">prostaglandins</a> (e.g., <a href="/wiki/Prostaglandin_E" title="Prostaglandin E">PGE</a><sub>2</sub>) from many cell types (<a href="/wiki/Fibroblasts" class="mw-redirect" title="Fibroblasts">fibroblasts</a>, <a href="/wiki/Endothelial_cells" class="mw-redirect" title="Endothelial cells">endothelial cells</a>, <a href="/wiki/Epithelial_cells" class="mw-redirect" title="Epithelial cells">epithelial cells</a>, <a href="/wiki/Keratinocytes" class="mw-redirect" title="Keratinocytes">keratinocytes</a>, and <a href="/wiki/Macrophages" class="mw-redirect" title="Macrophages">macrophages</a>). IL-17 acts with <a href="/wiki/Interleukin_22" title="Interleukin 22">IL-22</a> (produced mainly by <a href="/w/index.php?title=T_helper_22&action=edit&redlink=1" class="new" title="T helper 22 (page does not exist)">T helper 22</a> cells in humans, but by <a href="/wiki/T_helper_17_cell" title="T helper 17 cell">T helper 17 cell</a> in mice) to induce expression of antimicrobial peptide by <a href="/wiki/Keratinocytes" class="mw-redirect" title="Keratinocytes">keratinocytes</a>. </p><p>The release of cytokines causes many functions, such as airway remodeling, a characteristic of IL-17 responses. The increased expression of chemokines attracts other cells including neutrophils but not eosinophils. IL-17 function is also essential to a subset of <a href="/wiki/CD4" title="CD4">CD4</a>+ T-Cells called <a href="/wiki/T_helper_17_cell" title="T helper 17 cell">T helper 17</a> (T<sub>h</sub>17) cells. As a result of these roles, the IL-17 family has been linked to many immune-related/autoimmune diseases including <a href="/wiki/Rheumatoid_arthritis" title="Rheumatoid arthritis">rheumatoid arthritis</a>, <a href="/wiki/Asthma" title="Asthma">asthma</a>, <a href="/wiki/Lupus_erythematosus" title="Lupus erythematosus">lupus</a>, <a href="/wiki/Allograft" class="mw-redirect" title="Allograft">allograft</a> rejection, anti-tumour immunity and recently <a href="/wiki/Psoriasis" title="Psoriasis">psoriasis</a>,<sup id="cite_ref-aggaral_10-0" class="reference"><a href="#cite_note-aggaral-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Multiple_sclerosis" title="Multiple sclerosis">multiple sclerosis</a>,<sup id="cite_ref-ReferenceA_11-0" class="reference"><a href="#cite_note-ReferenceA-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Intracerebral_hemorrhage" title="Intracerebral hemorrhage">intracerebral hemorrhage</a>.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Gene_expression">Gene expression</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=3" title="Edit section: Gene expression"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/Gene" title="Gene">gene</a> for human IL-17A is 1874 <a href="/wiki/Base_pair" title="Base pair">base pairs</a> long<sup id="cite_ref-Yao1995_13-0" class="reference"><a href="#cite_note-Yao1995-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> and was cloned from CD4+ T cells. Each member of the IL-17 family has a distinct pattern of cellular <a href="/wiki/Gene_expression" title="Gene expression">expression</a>. The expression of IL-17A and IL-17F appear to be restricted to a small group of activated <a href="/wiki/T_cells" class="mw-redirect" title="T cells">T cells</a>, and upregulated during <a href="/wiki/Inflammation" title="Inflammation">inflammation</a>. IL-17B is expressed in several peripheral tissues and immune tissues. IL-17C is also highly upregulated in <a href="/wiki/Inflammation" title="Inflammation">inflammatory</a> conditions, although in resting conditions is low in abundance. IL-17D is highly expressed in the <a href="/wiki/Nervous_system" title="Nervous system">nervous system</a> and in <a href="/wiki/Skeletal_muscle" title="Skeletal muscle">skeletal muscle</a> and IL-17E is found at low levels in various peripheral tissues.<sup id="cite_ref-aggaral_10-1" class="reference"><a href="#cite_note-aggaral-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Much progress has been made in the understanding of the regulation of IL-17. At first, Aggarwal <i>et al.</i> showed that production of IL-17 was dependent on <a href="/wiki/Interleukin_23" title="Interleukin 23">IL-23</a>.<sup id="cite_ref-pmid12417590_14-0" class="reference"><a href="#cite_note-pmid12417590-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Later, a Korean group discovered that <a href="/wiki/STAT_protein" title="STAT protein">STAT3</a> and <a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> signalling pathways are required for this IL-23-mediated IL-17 production.<sup id="cite_ref-pmid16622035_15-0" class="reference"><a href="#cite_note-pmid16622035-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Consistent with this finding, Chen <i>et al.</i> showed that another molecule, <a href="/wiki/SOCS3" title="SOCS3">SOCS3</a>, plays an important role in IL-17 production.<sup id="cite_ref-pmid16698929_16-0" class="reference"><a href="#cite_note-pmid16698929-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> In the absence of SOCS3, IL-23-induced STAT3 <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylation</a> is enhanced, and phosphorylated STAT3 binds to the <a href="/wiki/Promoter_(biology)" class="mw-redirect" title="Promoter (biology)">promoter</a> regions of both IL-17A and IL-17F increasing their gene activity. In contrast, some scientists believe IL-17 induction is independent of IL-23. Several groups have identified ways to induce IL-17 production both <i>in vitro</i><sup id="cite_ref-Veldhoen2006_17-0" class="reference"><a href="#cite_note-Veldhoen2006-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> and <i>in vivo</i><sup id="cite_ref-Mangan2006_18-0" class="reference"><a href="#cite_note-Mangan2006-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bettelli2006_19-0" class="reference"><a href="#cite_note-Bettelli2006-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> by distinct cytokines, called <a href="/wiki/TGF-%CE%B2" class="mw-redirect" title="TGF-β">TGF-β</a> and <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a>, without the need for IL-23.<sup id="cite_ref-Veldhoen2006_17-1" class="reference"><a href="#cite_note-Veldhoen2006-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Mangan2006_18-1" class="reference"><a href="#cite_note-Mangan2006-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Bettelli2006_19-1" class="reference"><a href="#cite_note-Bettelli2006-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> Although IL-23 is not required for IL-17 expression in this situation, IL-23 may play a role in promoting survival and/or proliferation of the IL-17 producing <a href="/wiki/T-cell" class="mw-redirect" title="T-cell">T-cells</a>. Recently, Ivanov <i>et al.</i> found that the <a href="/wiki/Thymus" title="Thymus">thymus</a> specific <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">nuclear receptor</a>, <a href="/wiki/RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">ROR-γ</a>, directs differentiation of IL-17-producing T cells.<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=4" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>IL-17(A) is a 155-amino acid protein that is a <a href="/wiki/Disulfide" title="Disulfide">disulfide</a>-linked, <a href="/wiki/Protein_dimer" title="Protein dimer">homodimeric</a>, secreted <a href="/wiki/Glycoprotein" title="Glycoprotein">glycoprotein</a> with a molecular mass of 35 kDa.<sup id="cite_ref-Kolls2004_9-1" class="reference"><a href="#cite_note-Kolls2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Each subunit of the homodimer is approximately 15-20 KDa. The structure of IL-17 consists of a <a href="/wiki/Signal_peptide" title="Signal peptide">signal peptide</a> of 23 amino acids (aa) followed by a 123-aa chain region characteristic of the IL-17 family. An N-linked <a href="/wiki/Glycosylation" title="Glycosylation">glycosylation</a> site on the protein was first identified after purification of the protein revealed two bands, one at 15 KDa and another at 20 KDa. Comparison of different members of the IL-17 family revealed four conserved cysteines that form two <a href="/wiki/Disulfide_bond" class="mw-redirect" title="Disulfide bond">disulfide bonds</a>.<sup id="cite_ref-Yao1995_13-1" class="reference"><a href="#cite_note-Yao1995-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> IL-17 is unique in that it bears no resemblance to other known <a href="/wiki/Interleukin" title="Interleukin">interleukins</a>. Furthermore, IL-17 bears no resemblance to any other known proteins or structural domains.<sup id="cite_ref-aggaral_10-2" class="reference"><a href="#cite_note-aggaral-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>The crystal structure of IL-17F, which is 50% homologous to IL-17A, revealed that IL-17F is structurally similar to the cystine knot family of proteins that includes the <a href="/wiki/Neurotrophin" title="Neurotrophin">neurotrophins</a>. The <a href="/wiki/Cystine_knot" title="Cystine knot">cystine knot</a> fold is characterized by two sets of paired <a href="/wiki/%CE%92-strand" class="mw-redirect" title="Β-strand">β-strands</a> stabilized by three disulfide interactions. However, in contrast to the other cystine knot proteins, IL-17F lacks the third disulfide bond. Instead, a <a href="/wiki/Serine" title="Serine">serine</a> replaces the cysteine at this position. This unique feature is conserved in the other IL-17 family members. IL-17F also dimerizes in a fashion similar to <a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">nerve growth factor</a> (NGF) and other neurotrophins.<sup id="cite_ref-pmid11574464_1-1" class="reference"><a href="#cite_note-pmid11574464-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_psoriasis">Role in psoriasis</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=5" title="Edit section: Role in psoriasis"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Recent work suggests the IL-23/IL-17 pathway plays a major role in the autoimmune disorder <a href="/wiki/Psoriasis" title="Psoriasis">psoriasis</a>.<sup id="cite_ref-Martin_2013_8-1" class="reference"><a href="#cite_note-Martin_2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lowes_2014_21-0" class="reference"><a href="#cite_note-Lowes_2014-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hu_2011_22-0" class="reference"><a href="#cite_note-Hu_2011-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> In this condition, immune cells react to inflammatory molecules released within the skin around the joints and scalp.<sup id="cite_ref-Lowes_2014_21-1" class="reference"><a href="#cite_note-Lowes_2014-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> This response causes the epidermal cells to recycle more rapidly than usual, which leads to the formation of red, scaly lesions and chronic skin inflammation.<sup id="cite_ref-Hu_2011_22-1" class="reference"><a href="#cite_note-Hu_2011-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Baliwag_2015_23-0" class="reference"><a href="#cite_note-Baliwag_2015-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> Analysis of biopsies taken from lesions of psoriasis patients show an enrichment of cytotoxic T cells and neutrophils containing IL-17.<sup id="cite_ref-Lowes_2014_21-2" class="reference"><a href="#cite_note-Lowes_2014-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Mudigonda_2012_24-0" class="reference"><a href="#cite_note-Mudigonda_2012-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lin_2011_25-0" class="reference"><a href="#cite_note-Lin_2011-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> This indicates an excessive infiltration of pro-inflammatory immune cells and IL-17 cytokines are associated with the development of psoriasis. </p><p>Studies conducted in mice demonstrate that removing either IL-23 or IL-17 decreases the progression of psoriasis.<sup id="cite_ref-Nakajima_2011_26-0" class="reference"><a href="#cite_note-Nakajima_2011-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Krueger_2012_27-0" class="reference"><a href="#cite_note-Krueger_2012-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Mice injected with <a href="/wiki/Monoclonal_antibodies" class="mw-redirect" title="Monoclonal antibodies">monoclonal antibodies</a> targeting IL-17 blocked, or neutralized, down-stream signaling of this cytokine and decreased epidermal <a href="/wiki/Hyperplasia" title="Hyperplasia">hyperplasia</a>.<sup id="cite_ref-Nakajima_2011_26-1" class="reference"><a href="#cite_note-Nakajima_2011-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> Similarly, mice genetically modifying to not express IL-23 or IL-17 receptors significantly reduced psoriatic lesion development upon stimulation with the lesion-causing tumor promoter <a href="/wiki/12-O-tetradecanoylphorbol-13-acetate" class="mw-redirect" title="12-O-tetradecanoylphorbol-13-acetate">12-O-tetradecanoylphorbol-13-acetate</a>.<sup id="cite_ref-Martin_2013_8-2" class="reference"><a href="#cite_note-Martin_2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>IL-17 promotes psoriasis by contributing to the inflammatory response that damages and overturns the <a href="/wiki/Keratinocyte" title="Keratinocyte">keratinocyte</a> cells of the epidermal layer.<sup id="cite_ref-Lowes_2014_21-3" class="reference"><a href="#cite_note-Lowes_2014-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Krueger_2012_27-1" class="reference"><a href="#cite_note-Krueger_2012-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Inflammation begins with keratinocyte cells entering the final stages of their cell cycle, which activates immature <a href="/wiki/Dendritic_cell" title="Dendritic cell">dendritic cells</a> (DC).<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> Cytokines released from DCs stimulate dying keratinocytes to secrete <a href="/wiki/TNF-alpha" class="mw-redirect" title="TNF-alpha">TNF-alpha</a>, <a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">IL-1</a> and <a href="/wiki/Interleukin_6" title="Interleukin 6">IL-6</a> leading to the <a href="/wiki/Chemotaxis" title="Chemotaxis">chemotaxis</a> of <a href="/wiki/T_cells" class="mw-redirect" title="T cells">T cells</a>, <a href="/wiki/Natural_killer_cells" class="mw-redirect" title="Natural killer cells">natural killer cells</a> and <a href="/wiki/Monocytes" class="mw-redirect" title="Monocytes">monocytes</a> to the epidermis.<sup id="cite_ref-Baliwag_2015_23-1" class="reference"><a href="#cite_note-Baliwag_2015-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> These cells release IL-23 which induce <a href="/wiki/T_helper_17_cell" title="T helper 17 cell">Th17</a> cells to produce IL-17.<sup id="cite_ref-Mudigonda_2012_24-1" class="reference"><a href="#cite_note-Mudigonda_2012-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p><p>IL-17 interaction with IL-17RA receptors, abundant on the keratinocyte cell surface, incite epidermal cells to increase expression of IL-6, <a href="/wiki/Antimicrobial_peptides" title="Antimicrobial peptides">antimicrobial peptides</a>, <a href="/wiki/Interleukin_8" title="Interleukin 8">IL-8</a> and <a href="/wiki/CCL20" title="CCL20">CCL20</a>.<sup id="cite_ref-Martin_2013_8-3" class="reference"><a href="#cite_note-Martin_2013-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hu_2011_22-2" class="reference"><a href="#cite_note-Hu_2011-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Krueger_2012_27-2" class="reference"><a href="#cite_note-Krueger_2012-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Increased concentration of IL-6 alters the epidermal environment by decreasing the ability of <a href="/wiki/T-reg" class="mw-redirect" title="T-reg">T regulatory cells</a> to control the behavior of <a href="/wiki/T_helper_17_cell" title="T helper 17 cell">Th17</a> cells.<sup id="cite_ref-Mudigonda_2012_24-2" class="reference"><a href="#cite_note-Mudigonda_2012-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> Reduced regulation allows uninhibited proliferation of Th17 cells and production of IL-17 in psoriatic lesions, augmenting IL-17 signaling.<sup id="cite_ref-Mudigonda_2012_24-3" class="reference"><a href="#cite_note-Mudigonda_2012-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> Antimicrobial peptides and IL-8 attract neutrophils to the site of injury where these cells remove damaged and inflamed keratinocyte cells.<sup id="cite_ref-Lowes_2014_21-4" class="reference"><a href="#cite_note-Lowes_2014-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lin_2011_25-1" class="reference"><a href="#cite_note-Lin_2011-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Krueger_2012_27-3" class="reference"><a href="#cite_note-Krueger_2012-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> New immature DCs are also recruited by CCL20 via chemotaxis where their activation restarts and amplifies the cycle of inflammation.<sup id="cite_ref-Mudigonda_2012_24-4" class="reference"><a href="#cite_note-Mudigonda_2012-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lin_2011_25-2" class="reference"><a href="#cite_note-Lin_2011-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> IL-17 and additional cytokines released from the influx of neutrophils, T and dendritic cells mediate effects on localized leukocytes and keratinocytes that supports the progression of psoriasis by inciting chronic inflammation.<sup id="cite_ref-Mudigonda_2012_24-5" class="reference"><a href="#cite_note-Mudigonda_2012-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Role_in_asthma">Role in asthma</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=6" title="Edit section: Role in asthma"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The IL-17F gene was discovered in 2001 and is located on chromosome 6p12. Notably, among this family, IL-17F has been well characterized both in vitro and in vivo and has been shown to have a pro-inflammatory role in <a href="/wiki/Asthma" title="Asthma">asthma</a>. IL-17F is clearly expressed in the airway of asthmatics and its expression level is correlated with disease severity. Moreover, a coding region variant (H161R) of the IL-17F gene is inversely associated with asthma and encodes an antagonist for the wild-type IL-17F. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts and eosinophils. IL-17F utilizes IL-17RA and IL-17RC as its receptors and activates the <a href="/wiki/MAPK/ERK_pathway" title="MAPK/ERK pathway">MAP kinase-related pathway</a>. IL-17F is derived from several cell types such as Th17 cells, mast cells and basophils, and shows a wide tissue expression pattern including lung. Overexpression of IL-17F gene in the airway of mice is associated with airway neutrophilia, the induction of many cytokines, an increase in airway hyperreactivity, and mucus hypersecretion. Hence, IL-17F may have a crucial role in allergic airway inflammation and have important therapeutic implications in asthma.<sup id="cite_ref-pmid20025586_29-0" class="reference"><a href="#cite_note-pmid20025586-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Therapeutic_target">Therapeutic target</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=7" title="Edit section: Therapeutic target"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Because of its involvement in immune regulatory functions, IL-17 inhibitors are being investigated as possible treatments for <a href="/wiki/Autoimmune_disease" title="Autoimmune disease">autoimmune diseases</a> such as <a href="/wiki/Rheumatoid_arthritis" title="Rheumatoid arthritis">rheumatoid arthritis</a>, <a href="/wiki/Psoriasis" title="Psoriasis">psoriasis</a> and <a href="/wiki/Inflammatory_bowel_disease" title="Inflammatory bowel disease">inflammatory bowel disease</a>.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> In January 2015, the FDA approved the use of <a href="/wiki/Secukinumab" title="Secukinumab">secukinumab</a> (trade name <a href="/wiki/Secukinumab" title="Secukinumab">Cosentyx</a>), an IL-17 inhibiting <a href="/wiki/Monoclonal_antibody" title="Monoclonal antibody">monoclonal antibody</a>, for the treatment of moderate to severe plaque psoriasis.<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> In addition, Cosentyx has been approved in Japan for use in treating <a href="/wiki/Psoriatic_arthritis" title="Psoriatic arthritis">psoriatic arthritis</a>.<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> The anti-IL-23 antibody <a href="/wiki/Ustekinumab" title="Ustekinumab">ustekinumab</a> can also be used to effectively treat psoriasis by indirectly reducing IL-17.<sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> </p><p>Based on emerging evidence from animal models, IL-17 has been suggested as a target for anti-inflammatory therapies to improve recovery post-stroke<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> and to reduce the formation of skin cancer.<sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> IL-17 has also been implicated in <a href="/wiki/Multiple_sclerosis" title="Multiple sclerosis">multiple sclerosis</a>.<sup id="cite_ref-ReferenceA_11-1" class="reference"><a href="#cite_note-ReferenceA-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>The active form of <a href="/wiki/Vitamin_D" title="Vitamin D">vitamin D</a> has been found to 'severely impair' <sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> production of the <a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL-17</a> and <a href="#Family_members">IL-17F</a> cytokines by <a href="/wiki/T_helper_17_cell" title="T helper 17 cell">Th17</a> cells. </p> <div class="mw-heading mw-heading2"><h2 id="Receptors">Receptors</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=8" title="Edit section: Receptors"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">Interleukin-17 receptor</a></div> <p>The IL-17 receptor family consists of five, broadly distributed receptors (IL-17RA, B, C, D and E) that present with individual ligand specificities. Within this family of receptors, IL-17RA is the best-described. IL-17RA binds both IL-17A and IL-17F and is expressed in multiple tissues: vascular endothelial cells, peripheral T cells, B cell lineages, fibroblast, lung, myelomonocytic cells, and marrow stromal cells.<sup id="cite_ref-Kolls2004_9-2" class="reference"><a href="#cite_note-Kolls2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Kawaguchi2004_39-0" class="reference"><a href="#cite_note-Kawaguchi2004-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley_2003_2-1" class="reference"><a href="#cite_note-Moseley_2003-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Signal transduction for both IL-17A and IL-17F requires the presence of a heterodimeric complex consisting of both IL-17RA and IL-17RC and the absence of either receptor results in ineffective signal transduction. This pattern is reciprocated for other members of the IL-17 family such as IL-17E, which requires an IL-17RA-IL-17RB complex (also known as IL-17Rh1, IL-17BR or IL-25R) for effective function.<sup id="cite_ref-pmid21726218_40-0" class="reference"><a href="#cite_note-pmid21726218-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p><p>Another member of this receptor family, IL-17RB, binds both IL-17B and IL-17E.<sup id="cite_ref-Kolls2004_9-3" class="reference"><a href="#cite_note-Kolls2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley_2003_2-2" class="reference"><a href="#cite_note-Moseley_2003-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Furthermore, it is expressed in the kidney, pancreas, liver, brain, and intestine.<sup id="cite_ref-Kolls2004_9-4" class="reference"><a href="#cite_note-Kolls2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> IL-17RC is expressed by the prostate, cartilage, kidney, liver, heart, and muscle, and its gene may undergo <a href="/wiki/Alternate_splicing" class="mw-redirect" title="Alternate splicing">alternate splicing</a> to produce a soluble receptor in addition to its cell membrane-bound form. In a similar manner, the gene for IL-17RD may undergo alternative splicing to yield a soluble receptor. This feature may allow these receptors to inhibit the stimulatory effects of their yet-undefined ligands.<sup id="cite_ref-Kolls2004_9-5" class="reference"><a href="#cite_note-Kolls2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley_2003_2-3" class="reference"><a href="#cite_note-Moseley_2003-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> The least-described of these receptors, IL-17RE, is known to be expressed in the pancreas, brain, and prostate.<sup id="cite_ref-Kolls2004_9-6" class="reference"><a href="#cite_note-Kolls2004-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Signal transduction by these receptors is as diverse as their distribution. These receptors do not exhibit a significant similarity in extracellular or intracellular amino acid sequence when compared to other cytokine receptors.<sup id="cite_ref-Kawaguchi2004_39-1" class="reference"><a href="#cite_note-Kawaguchi2004-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> Transcription factors such as <a href="/wiki/TRAF" class="mw-redirect" title="TRAF">TRAF6</a>, <a href="/wiki/Janus_kinase" title="Janus kinase">JNK</a>, <a href="/wiki/Erk_kinase" class="mw-redirect" title="Erk kinase">Erk1/2</a>, p38, <a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> and <a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> have been implicated in IL-17 mediated signaling in a stimulation-dependent, tissue-specific manner.<sup id="cite_ref-Kawaguchi2004_39-2" class="reference"><a href="#cite_note-Kawaguchi2004-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Moseley_2003_2-4" class="reference"><a href="#cite_note-Moseley_2003-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16891673_41-0" class="reference"><a href="#cite_note-pmid16891673-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> Other signaling mechanisms have also been proposed, but more work is needed to fully elucidate the true signaling pathways used by these diverse receptors. </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_17&action=edit&section=9" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 33em;"> <ol class="references"> <li id="cite_note-pmid11574464-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid11574464_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid11574464_1-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><span class="plainlinks"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a>: <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1JPY">1JPY</a></span>; 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href="#cite_ref-Kawaguchi2004_39-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKawaguchiAdachiOdaKokubu2004" class="citation journal cs1">Kawaguchi M, Adachi M, Oda N, Kokubu F, Huang SK (December 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jaci.2004.10.019">"IL-17 cytokine family"</a>. <i>The Journal of Allergy and Clinical Immunology</i>. <b>114</b> (6): <span class="nowrap">1265–</span>73, quiz 1274. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.jaci.2004.10.019">10.1016/j.jaci.2004.10.019</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15577820">15577820</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Allergy+and+Clinical+Immunology&rft.atitle=IL-17+cytokine+family&rft.volume=114&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1265-%3C%2Fspan%3E73%2C+quiz+1274&rft.date=2004-12&rft_id=info%3Adoi%2F10.1016%2Fj.jaci.2004.10.019&rft_id=info%3Apmid%2F15577820&rft.aulast=Kawaguchi&rft.aufirst=M&rft.au=Adachi%2C+M&rft.au=Oda%2C+N&rft.au=Kokubu%2C+F&rft.au=Huang%2C+SK&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.jaci.2004.10.019&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+17" class="Z3988"></span></span> </li> <li id="cite_note-pmid21726218-40"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid21726218_40-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite 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href="/wiki/CCL12" title="CCL12">CCL12</a></li> <li><a href="/wiki/CCL13" title="CCL13">CCL13</a></li> <li><a href="/wiki/CCL14" title="CCL14">CCL14</a></li> <li><a href="/wiki/CCL15" title="CCL15">CCL15</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li> <li><a href="/wiki/CCL17" title="CCL17">CCL17</a></li> <li><a href="/wiki/CCL18" title="CCL18">CCL18</a>/PARC/DCCK1/AMAC1/MIP4</li> <li><a href="/wiki/CCL19" title="CCL19">CCL19</a></li> <li><a href="/wiki/CCL20" title="CCL20">CCL20</a></li> <li><a href="/wiki/CCL21" title="CCL21">CCL21</a></li> <li><a href="/wiki/CCL22" title="CCL22">CCL22</a></li> <li><a href="/wiki/CCL23" title="CCL23">CCL23</a></li> <li><a href="/wiki/CCL24" title="CCL24">CCL24</a></li> <li><a href="/wiki/CCL25" title="CCL25">CCL25</a></li> <li><a href="/wiki/CCL26" title="CCL26">CCL26</a></li> <li><a href="/wiki/C-C_motif_chemokine_ligand_27" title="C-C motif chemokine ligand 27">CCL27</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">CXCL</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CXCL1" title="CXCL1">CXCL1</a>/KC</li> <li><a href="/wiki/CXCL2" title="CXCL2">CXCL2</a></li> <li><a href="/wiki/CXCL3" title="CXCL3">CXCL3</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">CXCL4</a></li> <li><a href="/wiki/CXCL5" title="CXCL5">CXCL5</a></li> <li><a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/wiki/CXCL7" title="CXCL7">CXCL7</a></li> <li><a href="/wiki/Interleukin_8" title="Interleukin 8">CXCL8/IL8</a></li> <li><a href="/wiki/CXCL9" title="CXCL9">CXCL9</a></li> <li><a href="/wiki/CXCL10" title="CXCL10">CXCL10</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11</a></li> <li><a href="/wiki/SDF-1_(biology)" class="mw-redirect" title="SDF-1 (biology)">CXCL12</a></li> <li><a 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href="/wiki/Tumor_necrosis_factors" class="mw-redirect" title="Tumor necrosis factors">TNF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li> <li><a href="/wiki/Lymphotoxin" title="Lymphotoxin">Lymphotoxin</a> <ul><li><a href="/wiki/Lymphotoxin_alpha" title="Lymphotoxin alpha">TNFB/LTA</a></li> <li><a href="/wiki/Lymphotoxin_beta" title="Lymphotoxin beta">TNFC/LTB</a></li></ul></li> <li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L">TNFSF4</a></li> <li><a href="/wiki/CD154" title="CD154">TNFSF5/CD40LG</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">TNFSF6</a></li> <li><a href="/wiki/CD70" title="CD70">TNFSF7</a></li> <li><a href="/wiki/CD153" title="CD153">TNFSF8</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">TNFSF9</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">TNFSF10</a></li> <li><a href="/wiki/RANKL" title="RANKL">TNFSF11</a></li> <li><a href="/wiki/A_proliferation-inducing_ligand" class="mw-redirect" title="A proliferation-inducing ligand">TNFSF13</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">TNFSF13B</a></li> <li><a href="/wiki/EDA_(gene)" class="mw-redirect" title="EDA (gene)">EDA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I</a><br />(grouped by<br />receptor<br />subunit)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Common_gamma_chain" title="Common gamma chain">γ chain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_2" title="Interleukin 2">IL2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">IL15</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a>/<a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li> <li><a href="/wiki/Interleukin_7" title="Interleukin 7">IL7</a></li> <li><a href="/wiki/Interleukin_9" title="Interleukin 9">IL9</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">IL21</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CSF2RB" title="CSF2RB">β chain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_3" title="Interleukin 3">IL3</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor">GMCSF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">IL6 like/<a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">gp130</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_11" title="Interleukin 11">IL11</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_30" title="Interleukin 30">IL30</a></li> <li><a href="/wiki/Interleukin_31" title="Interleukin 31">IL31</a> <ul><li>+non IL <a href="/wiki/Oncostatin_M" title="Oncostatin M">OSM</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">LIF</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor" title="Ciliary neurotrophic factor">CNTF</a></li> <li><a href="/wiki/Cardiotrophin_1" title="Cardiotrophin 1">CTF1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=IL12_family&action=edit&redlink=1" class="new" title="IL12 family (page does not exist)">IL12 family</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_12" title="Interleukin 12">IL12</a></li> <li><a href="/wiki/Interleukin_23" title="Interleukin 23">IL23</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">IL35</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-taxilin" title="Alpha-taxilin">IL14</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">IL16</a></li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">IL32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">IL34</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL10_family" class="mw-redirect" title="IL10 family">IL10 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a>/<a href="/wiki/Interleukin_22" title="Interleukin 22">IL22</a></li> <li><a href="/wiki/Interleukin_19" title="Interleukin 19">IL19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">IL20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">IL24</a></li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">IL26</a></li> <li><a href="/wiki/Interferon_type_III" title="Interferon type III">Interferon type III</a> <ul><li><a href="/wiki/Interleukin_28" title="Interleukin 28">IL28/IFNL2+3</a></li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">IL29/IFNL1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon" title="Interferon">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_I" title="Interferon type I">I</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_alpha_1" class="mw-redirect" title="Interferon alpha 1">IFNA1</a></li> <li><a href="/wiki/IFNA2" title="IFNA2">IFNA2</a></li> <li><a href="/wiki/IFNA4" title="IFNA4">IFNA4</a></li> <li><a href="/wiki/IFNA5" title="IFNA5">IFNA5</a></li> <li><a href="/wiki/IFNA6" title="IFNA6">IFNA6</a></li> <li><a href="/wiki/IFNA7" title="IFNA7">IFNA7</a></li> <li><a href="/wiki/IFNA8" title="IFNA8">IFNA8</a></li> <li><a href="/wiki/IFNA10" title="IFNA10">IFNA10</a></li> <li><a href="/wiki/IFNA13" title="IFNA13">IFNA13</a></li> <li><a href="/wiki/IFNA14" title="IFNA14">IFNA14</a></li> <li><a href="/wiki/IFNA16" title="IFNA16">IFNA16</a></li> <li><a href="/wiki/IFNA17" title="IFNA17">IFNA17</a></li> <li><a href="/wiki/IFNA21" title="IFNA21">IFNA21</a></li> <li><a href="/wiki/IFNB1" title="IFNB1">IFNB1</a></li> <li><a href="/wiki/IFNK" title="IFNK">IFNK</a></li> <li><a href="/wiki/IFNW1" title="IFNW1">IFNW1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_II" class="mw-redirect" title="Interferon type II">II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNG</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Ig superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_1_family" class="mw-redirect" title="Interleukin 1 family">IL1 family</a>: <a href="/wiki/IL1A" class="mw-redirect" title="IL1A">IL1A/IL1F1</a></li> <li><a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">IL1B/IL1F2</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">1Ra/IL1F3</a></li> <li><a href="/wiki/IL1F5" class="mw-redirect" title="IL1F5">IL1F5</a></li> <li><a href="/wiki/IL36A" title="IL36A">IL1F6</a></li> <li><a href="/wiki/IL1F7" class="mw-redirect" title="IL1F7">IL1F7</a></li> <li><a href="/wiki/IL36B" title="IL36B">IL1F8</a></li> <li><a href="/wiki/IL1F9" class="mw-redirect" title="IL1F9">IL1F9</a></li> <li><a href="/wiki/IL1F10" title="IL1F10">IL1F10</a></li> <li><a href="/wiki/Interleukin_33" title="Interleukin 33">33/IL1F11</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">18/IL1G</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL17_family" class="mw-redirect" title="IL17 family">IL17 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">IL17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">IL25</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hematopoietic" class="mw-redirect" title="Hematopoietic">Hematopoietic</a> <ul><li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">KITLG</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li></ul></li> <li><a href="/wiki/Osteopontin" title="Osteopontin">SPP1</a></li> <li><a href="/wiki/Macrophage_migration_inhibitory_factor" title="Macrophage migration inhibitory factor">MIF</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">By function/<br />cell</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Proinflammatory_cytokine" class="mw-redirect" title="Proinflammatory cytokine">proinflammatory cytokine</a></i> <ul><li><a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">IL1</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li></ul></li></ul> <ul><li><a href="/wiki/Monokine" title="Monokine">Monokine</a></li> <li><a href="/wiki/Lymphokine" title="Lymphokine">Lymphokine</a> <ul><li><i>T<sub>h</sub>1</i> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNγ</a></li> <li><a href="/wiki/Tumor_necrosis_factor_beta" class="mw-redirect" title="Tumor necrosis factor beta">TNFβ</a></li></ul></li> <li><i>T<sub>h</sub>2</i> <ul><li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li></ul></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Interleukin_receptor_modulators601" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Interleukin_receptor_modulators" title="Template talk:Interleukin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Interleukin_receptor_modulators" title="Special:EditPage/Template:Interleukin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Interleukin_receptor_modulators601" style="font-size:114%;margin:0 4em"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">Interleukin 1</a> (<a href="/wiki/Interleukin_1_alpha" class="mw-redirect" title="Interleukin 1 alpha">α</a>, <a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">β</a>)</li> <li><a href="/w/index.php?title=Mobenakin&action=edit&redlink=1" class="new" title="Mobenakin (page does not exist)">Mobenakin</a></li> <li><a href="/w/index.php?title=Pifonakin&action=edit&redlink=1" class="new" title="Pifonakin (page does not exist)">Pifonakin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=AF-12198&action=edit&redlink=1" class="new" title="AF-12198 (page does not exist)">AF-12198</a></li> <li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1RA</a></li> <li><a href="/w/index.php?title=Isunakinra&action=edit&redlink=1" class="new" title="Isunakinra (page does not exist)">Isunakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a href="/w/index.php?title=Lutikizumab&action=edit&redlink=1" class="new" title="Lutikizumab (page does not exist)">Lutikizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept (IL-1 Trap)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-2_receptor" class="mw-redirect" title="Interleukin-2 receptor">IL-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Adargileukin_alfa&action=edit&redlink=1" class="new" title="Adargileukin alfa (page does not exist)">Adargileukin alfa</a></li> <li><a href="/wiki/Aldesleukin" class="mw-redirect" title="Aldesleukin">Aldesleukin</a></li> <li><a href="/w/index.php?title=Celmoleukin&action=edit&redlink=1" class="new" title="Celmoleukin (page does not exist)">Celmoleukin</a></li> <li><a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a></li> <li><a href="/wiki/Interleukin_2" title="Interleukin 2">Interleukin 2</a></li> <li><a href="/w/index.php?title=Pegaldesleukin&action=edit&redlink=1" class="new" title="Pegaldesleukin (page does not exist)">Pegaldesleukin</a></li> <li><a href="/w/index.php?title=Teceleukin&action=edit&redlink=1" class="new" title="Teceleukin (page does not exist)">Teceleukin</a></li> <li><a href="/wiki/Tucotuzumab_celmoleukin" title="Tucotuzumab celmoleukin">Tucotuzumab celmoleukin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab (dacliximab)</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL-3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Daniplestim&action=edit&redlink=1" class="new" title="Daniplestim (page does not exist)">Daniplestim</a></li> <li><a href="/wiki/Interleukin_3" title="Interleukin 3">Interleukin 3</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/w/index.php?title=Muplestim&action=edit&redlink=1" class="new" title="Muplestim (page does not exist)">Muplestim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL-4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Pitrakinra" title="Pitrakinra">Pitrakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL-5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=YM-90709&action=edit&redlink=1" class="new" title="YM-90709 (page does not exist)">YM-90709</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li></ul> <ul><li><i>Antisense oligonucleotides:</i> <a href="/w/index.php?title=TPI_ASM8&action=edit&redlink=1" class="new" title="TPI ASM8 (page does not exist)">TPI ASM8</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL-6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Atexakin_alfa&action=edit&redlink=1" class="new" title="Atexakin alfa (page does not exist)">Atexakin alfa</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">Interleukin 6</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=ARGX-109&action=edit&redlink=1" class="new" title="ARGX-109 (page does not exist)">ARGX-109</a></li> <li><a href="/wiki/Clazakizumab" title="Clazakizumab">Clazakizumab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/w/index.php?title=MAb_1339&action=edit&redlink=1" class="new" title="MAb 1339 (page does not exist)">mAb 1339</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Levilimab" title="Levilimab">Levilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL-7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_7" title="Interleukin 7">Interleukin 7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_9_receptor" class="mw-redirect" title="Interleukin 9 receptor">IL-9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_9" title="Interleukin 9">Interleukin 9</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Enokizumab&action=edit&redlink=1" class="new" title="Enokizumab (page does not exist)">Enokizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL-10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ilodecakin&action=edit&redlink=1" class="new" title="Ilodecakin (page does not exist)">Ilodecakin</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">Interleukin 10 (CSIF)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">IL-11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_11" title="Interleukin 11">Interleukin 11 (AGIF)</a></li> <li><a href="/wiki/Oprelvekin" title="Oprelvekin">Oprelvekin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL-12</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Edodekin_alfa&action=edit&redlink=1" class="new" title="Edodekin alfa (page does not exist)">Edodekin alfa</a></li> <li><a href="/wiki/Interleukin_12" title="Interleukin 12">Interleukin 12</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL-13</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/w/index.php?title=Cintredekin_besudotox&action=edit&redlink=1" class="new" title="Cintredekin besudotox (page does not exist)">Cintredekin besudotox</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-15_receptor" title="Interleukin-15 receptor">IL-15</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/ALT-803" class="mw-redirect" title="ALT-803">ALT-803</a></li> <li><a href="/wiki/Interleukin_15" title="Interleukin 15">Interleukin 15</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL-17</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a class="mw-selflink selflink">Interleukin 17</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">A</a>, <a href="/w/index.php?title=IL17B&action=edit&redlink=1" class="new" title="IL17B (page does not exist)">B</a>, <a href="/w/index.php?title=IL17C&action=edit&redlink=1" class="new" title="IL17C (page does not exist)">C</a>, <a href="/w/index.php?title=IL17D&action=edit&redlink=1" class="new" title="IL17D (page does not exist)">D</a>, <a href="/wiki/IL17E" class="mw-redirect" title="IL17E">E (interleukin 25)</a>, <a href="/wiki/IL17F" class="mw-redirect" title="IL17F">F</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/w/index.php?title=Remtolumab&action=edit&redlink=1" class="new" title="Remtolumab (page does not exist)">Remtolumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/w/index.php?title=Vunakizumab&action=edit&redlink=1" class="new" title="Vunakizumab (page does not exist)">Vunakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL-18</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Iboctadekin&action=edit&redlink=1" class="new" title="Iboctadekin (page does not exist)">Iboctadekin</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">Interleukin 18</a></li> <li><a href="/wiki/Interleukin_37" title="Interleukin 37">Interleukin 37</a></li> <li><a href="/w/index.php?title=Tadekinig&action=edit&redlink=1" class="new" title="Tadekinig (page does not exist)">Tadekinig</a></li></ul> <ul><li><i>Binding proteins:</i> <a href="/wiki/IL18BP" title="IL18BP">IL18BP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL-20</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_19" title="Interleukin 19">Interleukin 19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">Interleukin 20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a> (against IL-20)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL-21</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Denenicokin&action=edit&redlink=1" class="new" title="Denenicokin (page does not exist)">Denenicokin</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">Interleukin 21</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=NNC0114-0005&action=edit&redlink=1" class="new" title="NNC0114-0005 (page does not exist)">NNC0114-0005</a></li> <li><a href="/w/index.php?title=NNC0114-0006&action=edit&redlink=1" class="new" title="NNC0114-0006 (page does not exist)">NNC0114-0006</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL-22</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_22" title="Interleukin 22">Interleukin 22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a> (against IL-22)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL-23</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_23" title="Interleukin 23">Interleukin 23 (SGRF)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">IL-27</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_27" title="Interleukin 27">Interleukin 27 (interleukin 30)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL-28</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Interferon_%CE%BB4&action=edit&redlink=1" class="new" title="Interferon λ4 (page does not exist)">Interferon λ4 (IFN-λ4)</a></li> <li><a href="/wiki/Interleukin_28" title="Interleukin 28">Interleukin 28</a> (<a href="/w/index.php?title=Interleukin_28A&action=edit&redlink=1" class="new" title="Interleukin 28A (page does not exist)">A (IFN-λ2)</a>, <a href="/wiki/Interleukin_28B" class="mw-redirect" title="Interleukin 28B">B (IFN-λ3)</a>)</li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">Interleukin-29 (IFN-λ1)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-31_receptor" title="Interleukin-31 receptor">IL-31</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_31" title="Interleukin 31">Interleukin 31</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_1" class="mw-redirect" title="Interleukin 1 receptor-like 1">IL1RL1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_33" title="Interleukin 33">Interleukin 33</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_2" class="mw-redirect" title="Interleukin 1 receptor-like 2">IL1RL2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_36" title="Interleukin 36">Interleukin 36</a> (<a href="/wiki/IL36A" title="IL36A">α</a>, <a href="/wiki/IL36B" title="IL36B">β</a>, <a href="/wiki/IL36G" title="IL36G">γ</a>)</li> <li><a href="/wiki/Interleukin_38" class="mw-redirect" title="Interleukin 38">Interleukin 38</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Interleukin_36_receptor_antagonist" title="Interleukin 36 receptor antagonist">IL-36RA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_14" class="mw-redirect" title="Interleukin 14">Interleukin 14 (taxilin alpha, HMW-BCGF)</a></li> <li><a href="/wiki/Interleukin_16" title="Interleukin 16">Interleukin 16</a> (signals through <a href="/wiki/CD4" title="CD4">CD4</a>)</li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a> (signals through <a href="/wiki/IL22RA1" title="IL22RA1">IL-22Rα1</a>/<a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL-20Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">Interleukin 26</a> (signals through <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL-20Rα</a>/<a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL-10Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">Interleukin 32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">Interleukin 34</a> (signals through <a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">M-CSFR/CSF1R</a>)</li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">Interleukin 35</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/Efavaleukin_alfa" title="Efavaleukin alfa">Efavaleukin alfa</a></li> <li><a href="/w/index.php?title=Efineptakin_alfa&action=edit&redlink=1" class="new" title="Efineptakin alfa (page does not exist)">Efineptakin alfa</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Interleukin_17&oldid=1234269743">https://en.wikipedia.org/w/index.php?title=Interleukin_17&oldid=1234269743</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_6" title="Category:Genes on human chromosome 6">Genes on human 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