CINXE.COM

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clearfix"> <div class="col-xs-12 col-sm-8 col-md-9 col-lg-9 col-xl-9 et_pharm_browser_wrapper"> <h1>Protein Arginine Methyltransferases</h1> <p><strong>Protein arginine methyltransferases</strong> are enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to the arginine residues on histones and other proteins. The dysregulation of this methylation is critical in the development of certain <a href='/research-area/cancer-research' title='Browse products for Cancer Research'>cancers</a>.</p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Products</span></div> <div class="tab tab_2" data-tab="2" data-tabname="background" id="pharm_tabs_background"><span>Background</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="literature" id="pharm_tabs_literature"><span>Literature (1)</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="gene" id="pharm_tabs_gene"> <span>Gene Data</span></div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_products"><table class="pharm_prod_table table table-condensed"> <tr> <th colspan="2"><h3><a href="/pharmacology/protein-arginine-methyltransferases/inhibitors" title="View all Protein Arginine Methyltransferase Inhibitor products">Protein Arginine Methyltransferase Inhibitors</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>6516</td> <td><a href="/products/epz-015666_6516" title="View price & availability information for EPZ 015666">EPZ 015666</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective PRMT5 inhibitor</td> </tr> <tr> <td>5202</td> <td><a href="/products/furamidine-dihydrochloride_5202" title="View price & availability information for Furamidine dihydrochloride">Furamidine dihydrochloride</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Selective PRMT1 inhibitor</td> </tr> <tr> <td>5777</td> <td><a href="/products/gsk-591-dihydrochloride_5777" title="View price & availability information for GSK 591 dihydrochloride">GSK 591 dihydrochloride</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective PRMT5 inhibitor</td> </tr> <tr> <td>5713</td> <td><a href="/products/ms-023-dihydrochloride_5713" title="View price & availability information for MS 023 dihydrochloride">MS 023 dihydrochloride</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective type I PRMT inhibitor</td> </tr> <tr> <td>6825</td> <td><a href="/products/sgc-3027_6825" title="View price & availability information for SGC 3027">SGC 3027</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective PRMT7 inhibitor</td> </tr> <tr> <td>7182</td> <td><a href="/products/sgc-6870_7182" title="View price & availability information for SGC 6870">SGC 6870</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective PRMT6 allosteric inhibitor</td> </tr> <tr> <td>5367</td> <td><a href="/products/sgc-707_5367" title="View price & availability information for SGC 707">SGC 707</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective allosteric inhibitor of PRMT3</td> </tr> <tr> <td>6008</td> <td><a href="/products/tp-064_6008" title="View price & availability information for TP 064">TP 064</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent and selective PRMT 4 inhibitor</td> </tr> <tr> <td>5057</td> <td><a href="/products/unc-2327_5057" title="View price & availability information for UNC 2327">UNC 2327</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Allosteric inhibitor of PRMT3</td> </tr> <tr> <th colspan="2"><h3><a href="/pharmacology/protein-arginine-methyltransferases/controls" title="View all Protein Arginine Methyltransferase Control products">Controls</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>6838</td> <td><a href="/products/sgc-3027n_6838" title="View price & availability information for SGC 3027N">SGC 3027N</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Negative control for <a href='/products/sgc-3027_6825'>SGC 3027</a> (Cat. No. 6825)</td> </tr> <tr> <td>7184</td> <td><a href="/products/sgc-6870n_7184" title="View price & availability information for SGC 6870N">SGC 6870N</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Negative control for <a href='/products/sgc-6870_7182'>SGC 6870</a> (Cat. No. 7182)</td> </tr> <tr> <td>5450</td> <td><a href="/products/xy1_5450" title="View price & availability information for XY1">XY1</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Negative control of <a href='/products/sgc-707_5367'>SGC 707</a> (Cat. No. 5367)</td> </tr></table></div> <div class="pharm_rel_cats"><h3>Related Targets</h3><ul class="tile_column_1"><li><a href="/pharmacology/dna-methyltransferases" title="Browse products for DNA Methyltransferases">DNA Methyltransferases</a></li><li><a href="/pharmacology/lysine-methyltransferases" title="Browse products for Lysine Methyltransferases">Lysine Methyltransferases</a></li></ul><ul class="tile_column_2"><li><a href="/pharmacology/other-transferases" title="Browse products for Other Transferases">Other Transferases</a></li></ul></div> </div> <div class="tab_content tab_2" data-tab="2"> <p><strong>Protein Arginine methyltransferases</strong>, or PRMTs, are a family of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine residues on histones. PRMTs belong to the histone methyltransferase group of enzymes, which also includes <a href='/pharmacology/lysine-methyltransferases' title='View products for Lysine Methyltransferases'> lysine methyltransferases</a>. They are also closely related in biological activity to the <a href='/pharmacology/dna-methyltransferases' title='Browse products for DNA methyltransferases'>DNA methyltransferases</a> and are ubiquitously expressed. Histone methylation of arginine residues occurs predominantly on histones H2A, H3 and H4, and multiple methyl groups may be added to each residue.</p> <p>Histones represent the major protein component of chromatin, around which DNA is coiled within the nucleus. Modification of histone protein by methylation induces chromatin remodeling which in turn alters gene expression. Histone methylation is an integral <a href='/cell-biology/epigenetics' title='View products for Epigenetics research'>epigenetic</a> process during development that represents an important mechanism of transcriptional regulation and chromatin remodeling. Dysregulation of histone methylation has been implicated in diseases, including <a href='/research-area/cancer-research' title='Browse products for Cancer Research'>cancer</a>.</p> <p>The epigenetic effects of histone methylation are dependent on the residue undergoing methylation, the degree of methylation and the modifying enzyme. PRMT methylation of histones may induce or inhibit transcription. In addition to histone methylation PRMTs have other effects including methylating and modulating transcription factors and effects on RNA stability and splicing </p><h3>External sources of pharmacological information for Protein Arginine Methyltransferases : </h3><ul class="tile_column_1"><li><a href="https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=254" target="_blank" rel="nofollow">IUPHAR Receptor Code</a></li></ul><ul class="tile_column_2"><li><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13877" target="_blank" rel="nofollow">BJP Guide</a></li></ul> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> <h3>Literature for Protein Arginine Methyltransferases</h3><p>Tocris offers the following scientific literature for Protein Arginine Methyltransferases to showcase our products. We invite you to request* your copy today!</p><p class="small">*Please note that Tocris will only send literature to established scientific business / institute addresses.</p><hr/><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/reviews/fullsize/417572.jpg?v=2" data-toggle="lightbox" data-title="Epigenetics Scientific Review" data-footer="<a href='/literature/literature-request/417572' rel='nofollow' title='Request copy of the Epigenetics'>Request copy</a> or <a href='/literature/literature-request/p417572' rel='nofollow' title='Request PDF of the Epigenetics'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/reviews/regular/417572.jpg?v=2" alt="Epigenetics Scientific Review" class="img-fluid"></a></div> <h4>Epigenetics Scientific Review</h4> <p>Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.</p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/417572" rel="nofollow" title="Request copy of the Epigenetics Scientific Review">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p417572" rel="nofollow" title="Request PDF of the Epigenetics Scientific Review">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/scientific-reviews" title="View all Scientific Reviews">View all Scientific Reviews</a></li> </ul> </div></div> </div> <div class="tab_content tab_5" data-tab="5"> </div> <div class="tab_content tab_6" data-tab="6"> <H3>Protein Arginine Methyltransferase Gene Data</H3> <table class="table table-responsive"> <tr> <th style='width:21%' title='Gene'> Gene </th> <th style='width:13%' title='Species'> Species </th> <th style='width:16%' title='The official gene symbol that has been approved by the HGNC'> Gene Symbol </th> <th style='width:25%' title='A unique identifier for a gene sequence record from the Reference Sequence database'> Gene Accession No. </th> <th style='width:25%' title='A unique identifier for a protein sequence record from the UniProt Protein Knowledgebase'> Protein Accession No. </th> </tr> <tr> <td style='width:21%' class='pb_bld' rowspan='3'> Protein arginine methyltransferase 1 </td> <td style='width:13%' class='pb_bld'> Human </td> <td style='width:16%'> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5187 ' target='_blank'>PRMT1</a> </td> <td style='width:25%'> NM_001207042 </td> <td style='width:25%'> Q99873 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:107846 ' target='_blank'>Prmt1</a> </td> <td> NP_062804 </td> <td> Q9JIF0 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=62020' target='_blank'>Prmt1</a> </td> <td> NM_024363 </td> <td> Q63009 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Protein arginine methyltransferase 2 </td> <td class='pb_bld'> Human </td> <td> <a href=' https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5186 ' target='_blank'>PRMT2</a> </td> <td> NM_001535 </td> <td> P55345 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:1316652' target='_blank'>Prmt2</a> </td> <td> NP_001071106 </td> <td> Q9R144 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1565519 ' target='_blank'>Prmt2</a> </td> <td> NM_001025144 </td> <td> Q6AYB9 </td> </tr> <tr> <td style='width:21%' class='pb_bld' rowspan='3'> Protein arginine methyltransferase 3 </td> <td style='width:13%' class='pb_bld'> Human </td> <td style='width:16%'> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30163 ' target='_blank'>PRMT3</a> </td> <td style='width:25%'> NM_005788 </td> <td style='width:25%'> O60678 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:1919224 ' target='_blank'>Prmt3</a> </td> <td> NP_598501 </td> <td> Q922H1 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=620413' target='_blank'>Prmt3</a> </td> <td> NM_053557 </td> <td> O70467 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Coactivator-associated arginine methyltransferase 1 (PRMT4) </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23393 ' target='_blank'>CARM1</a> </td> <td> XM_032719 </td> <td> Q86X55 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:1913208 ' target='_blank'>Carm1</a> </td> <td> NP_067506 </td> <td> Q9WVG6 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1305879 ' target='_blank'>Carm1</a> </td> <td> NM_0010300414 </td> <td> Q4AE70 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Protein arginine methyltransferase 5 </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10894 ' target='_blank'>PRMT5</a> </td> <td> NM_001039619 </td> <td> O14744 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:1351645 ' target='_blank'>Prmt5</a> </td> <td> NP_038796 </td> <td> Q8CIG8 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1309053 ' target='_blank'>Prmt5</a> </td> <td> NM_001108867 </td> <td> D4A0E8 </td> </tr> <tr> <td style='width:21%' class='pb_bld' rowspan='3'> Protein arginine methyltransferase 6 </td> <td style='width:13%' class='pb_bld'> Human </td> <td style='width:16%'> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18241' target='_blank'>PRMT6</a> </td> <td style='width:25%'> NM_018137 </td> <td style='width:25%'> Q96LA8 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:2139971' target='_blank'>Prmt6</a> </td> <td> NM_178891 </td> <td> Q6NZB1 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1304701' target='_blank'>Prmt6</a> </td> <td> NM_001106466 </td> <td> D4A307 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Protein arginine methyltransferase 7 </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25557' target='_blank'>PRMT7</a> </td> <td> NM_019023 </td> <td> Q9NVM4 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:2384879' target='_blank'>Prmt7</a> </td> <td> NM_145404 </td> <td> Q922X9 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1304869' target='_blank'>Prmt7</a> </td> <td> NM_001014153 </td> <td> Q5U4E8 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> Protein arginine methyltransferase 8 </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5188' target='_blank'>PRMT8</a> </td> <td> NM_019854 </td> <td> Q9NR22 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:3043083' target='_blank'>Prmt8</a> </td> <td> NM_201371 </td> <td> Q6PAK3 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1587677' target='_blank'>Prmt8</a> </td> <td> XM_002726433 </td> <td> F1LWG2 </td> </tr> </table> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> 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