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window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":25798108,"created_at":"2016-06-02T03:40:34.471-07:00","from_world_paper_id":153751139,"updated_at":"2024-11-11T20:10:23.489-08:00","_data":{"grobid_abstract":"Local and superficial near-infrared ͑NIR͒ optical-property characterization of turbid biological tissues can be achieved by measurement of spatially resolved diffuse reflectance at small source-detector separations ͑Ͻ1.4 mm͒. However, in these conditions the inverse problem, i.e., calculation of localized absorption and the reduced scattering coefficients, is necessarily sensitive to the scattering phase function. This effect can be minimized if a new parameter of the phase function ␥, which depends on the first and the second moments of the phase function, is known. If ␥ is unknown, an estimation of this parameter can be obtained by the measurement, but the uncertainty of the absorption coefficient is increased. A spatially resolved reflectance probe employing multiple detector fibers ͑0.3-1.4 mm from the source͒ is described. Monte Carlo simulations are used to determine ␥, the reduced scattering and absorption coefficients from reflectance data. Probe performance is assessed by measurements on phantoms, the optical properties of which were measured by other techniques ͓frequency domain photon migration ͑FDPM͒ and spatially resolved transmittance͔. Our results show that changes in the absorption coefficient, the reduced scattering coefficient, and ␥ can be measured to within Ϯ0.005 mm Ϫ1 , Ϯ0.05 mm Ϫ1 , and Ϯ0.2, respectively. In vivo measurements performed intraoperatively on a human skull and brain are reported for four NIR wavelengths ͑674, 811, 849, 956 nm͒ when the spatially resolved probe and FDPM are used. The spatially resolved probe shows optimum measurement sensitivity in the measurement volume immediately beneath the probe ͑typically 1 mm 3 in tissues͒, whereas FDPM typically samples larger regions of tissues. Optical-property values for human skull, white matter, scar tissue, optic nerve, and tumors are reported that show distinct absorption and scattering differences between structures and a dependence on the phase-function parameter ␥.","publication_date":"1999,,","publication_name":"Applied Optics","grobid_abstract_attachment_id":"46161823"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"In Vivo Local Determination of Tissue Optical Properties: Applications to Human Brain","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [2974599]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" 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href="https://independent.academia.edu/NainaShah1">Naina Shah</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Optical properties of biological tissues: a review","attachmentId":35379968,"attachmentType":"pdf","work_url":"https://www.academia.edu/9081433/Optical_properties_of_biological_tissues_a_review","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/9081433/Optical_properties_of_biological_tissues_a_review"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="47244829" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/47244829/_title_Superficial_tissue_optical_property_determination_using_spatially_resolved_measurements_close_to_the_source_comparison_with_frequency_domain_photon_migration_measurements_title_"><title>Superficial tissue optical property determination using spatially resolved measurements close to the source: comparison with frequency-domain photon migration measurements</title></a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="15738105" href="https://independent.academia.edu/ChristianDepeursinge">Christian Depeursinge</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Optical Tomography and Spectroscopy of Tissue III, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"\u003ctitle\u003eSuperficial tissue optical property determination using spatially resolved measurements close to the source: comparison with frequency-domain photon migration measurements\u003c/title\u003e","attachmentId":66439797,"attachmentType":"pdf","work_url":"https://www.academia.edu/47244829/_title_Superficial_tissue_optical_property_determination_using_spatially_resolved_measurements_close_to_the_source_comparison_with_frequency_domain_photon_migration_measurements_title_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/47244829/_title_Superficial_tissue_optical_property_determination_using_spatially_resolved_measurements_close_to_the_source_comparison_with_frequency_domain_photon_migration_measurements_title_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="2885214" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/2885214/Local_optical_characterization_of_biological_tissues_in_vitro_and_in_vivo">Local optical characterization of biological tissues in vitro and in vivo</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="2974599" href="https://ircam.academia.edu/FredericBevilacqua">Frederic Bevilacqua</a></div><p class="ds-related-work--metadata ds2-5-body-xs">1998</p><p class="ds-related-work--abstract ds2-5-body-sm">Abstract Two methods for measuring the optical properties of tissue, ie reduced scattering and absorption coefficient, were developed. The first one was designed for in vitro investigations. It is based on the measurement of the spatially resolved transmittance through a tissue slab (typically 5mm thick). The second one was designed for local in vivo investigations. It is based on the measurement of the spatially-resolved diffuse reflectance, close to the source (< 2mm).</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Local optical characterization of biological tissues in vitro and in vivo","attachmentId":30818338,"attachmentType":"pdf","work_url":"https://www.academia.edu/2885214/Local_optical_characterization_of_biological_tissues_in_vitro_and_in_vivo","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/2885214/Local_optical_characterization_of_biological_tissues_in_vitro_and_in_vivo"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="75465929" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/75465929/Superficial_tissue_optical_property_determination_using_spatially_resolved_measurements_close_to_the_source_Comparison_with_frequency_domain_photonmigration_measurements">Superficial tissue optical property determination using spatially resolved measurements close to the source: Comparison with frequency domain photonmigration measurements</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="217579707" href="https://independent.academia.edu/JeffreyGross7">Jeffrey Gross</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of SPIE, the International Society for Optical Engineering, 1999</p><p class="ds-related-work--abstract ds2-5-body-sm">Résumé/Abstract Local and superficial optical property characterization of biological tissues can be performed by measuring spatially-resolved diffuse reflectance at small source-detector separations. Monte Carlo simulations and experiments were performed to assess the performance of a spatially-resolved reflectance probe, employing multiple detector fibers (0.3 to 1.4 mm from the source). Under these conditions, the inverse problem, ie calculating the absorption and reduced scattering coefficients, is necessarily sensitive to the phase ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Superficial tissue optical property determination using spatially resolved measurements close to the source: Comparison with frequency domain photonmigration measurements","attachmentId":83223908,"attachmentType":"pdf","work_url":"https://www.academia.edu/75465929/Superficial_tissue_optical_property_determination_using_spatially_resolved_measurements_close_to_the_source_Comparison_with_frequency_domain_photonmigration_measurements","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/75465929/Superficial_tissue_optical_property_determination_using_spatially_resolved_measurements_close_to_the_source_Comparison_with_frequency_domain_photonmigration_measurements"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="24947925" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24947925/Optical_Reflectance_and_Transmittance_of_Tissues_Principles_and_Applications">Optical Reflectance and Transmittance of Tissues: Principles and Applications</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="48097886" href="https://independent.academia.edu/KawanyFernandes">Kawany Fernandes</a></div><p class="ds-related-work--abstract ds2-5-body-sm">This paper presents a discussion of diagnostic and dosi-metric optical measurements in medicine and biology. The introduction covers the topics of tissue optical properties, tissue boundary conditions , and invasive versus noninvasive measurements. Clinical applications of therapeutic dosimetry and diagnostic spectroscopy are discussed. The principles of diffuse reflectance and transmittance measurements are presented. Experimental studies illustrate reflectance spectroscopy and steady-state versus time-resolved measurements.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Optical Reflectance and Transmittance of Tissues: Principles and Applications","attachmentId":45278578,"attachmentType":"pdf","work_url":"https://www.academia.edu/24947925/Optical_Reflectance_and_Transmittance_of_Tissues_Principles_and_Applications","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/24947925/Optical_Reflectance_and_Transmittance_of_Tissues_Principles_and_Applications"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="27316174" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/27316174/Optics_of_living_tissues_with_controlled_scattering_properties">Optics of living tissues with controlled scattering properties</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="51424042" href="https://independent.academia.edu/ElinaGenina">Elina Genina</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of SPIE - The International Society for Optical Engineering</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Optics of living tissues with controlled scattering properties","attachmentId":47572130,"attachmentType":"pdf","work_url":"https://www.academia.edu/27316174/Optics_of_living_tissues_with_controlled_scattering_properties","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/27316174/Optics_of_living_tissues_with_controlled_scattering_properties"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="4365941" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4365941/In_vitro_optical_properties_of_human_and_canine_brain_and_urinary_bladder_tissues_at_633_nm">In vitro optical properties of human and canine brain and urinary bladder tissues at 633 nm</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5336690" href="https://uncc.academia.edu/RobertSplinter">Robert Splinter</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Lasers in Surgery and Medicine, 1989</p><p class="ds-related-work--abstract ds2-5-body-sm">Absorption and scattering coefficients and scattering anisotropy factor are presented for human and canine cadaver tissues at the helium-neon wavelength (633 nm). Measurements were performed with an integrating sphere arrangement and analyzed with the diffusion approximation of the equation of radiative transfer adapted to Kubelka-Munk techniques.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"In vitro optical properties of human and canine brain and urinary bladder tissues at 633 nm","attachmentId":49906292,"attachmentType":"pdf","work_url":"https://www.academia.edu/4365941/In_vitro_optical_properties_of_human_and_canine_brain_and_urinary_bladder_tissues_at_633_nm","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/4365941/In_vitro_optical_properties_of_human_and_canine_brain_and_urinary_bladder_tissues_at_633_nm"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="23257284" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23257284/Determination_of_tissue_optical_properties_by_steady_state_spatial_frequency_domain_reflectometry">Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="45025363" href="https://tomowave.academia.edu/AlexanderOraevsky">Alexander Oraevsky</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Lasers in Medical Science, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Determination of tissue optical properties by steady-state spatial frequency-domain reflectometry","attachmentId":43735920,"attachmentType":"pdf","work_url":"https://www.academia.edu/23257284/Determination_of_tissue_optical_properties_by_steady_state_spatial_frequency_domain_reflectometry","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23257284/Determination_of_tissue_optical_properties_by_steady_state_spatial_frequency_domain_reflectometry"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="84839848" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84839848/Reflectance_based_determination_of_optical_properties_in_highly_attenuating_tissue">Reflectance-based determination of optical properties in highly attenuating tissue</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="8879721" href="https://uci.academia.edu/AnthonyDurkin">Anthony J. Durkin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biomedical Optics, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Reflectance-based determination of optical properties in highly attenuating tissue","attachmentId":89727638,"attachmentType":"pdf","work_url":"https://www.academia.edu/84839848/Reflectance_based_determination_of_optical_properties_in_highly_attenuating_tissue","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/84839848/Reflectance_based_determination_of_optical_properties_in_highly_attenuating_tissue"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":46161823,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":46161823,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_46161823" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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