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style='min-width: 970px; min-height: 90px;'><script>googletag.cmd.push(function() { googletag.display("jumbo-banner-ad-container"); });</script></div></div> <div class="archive-intro"><div class="wrap"><h1 class="archive-title"><span>Recalls</span></h1></div></div><div class="site-inner"><div class="wrap"><div class="content-sidebar-wrap"><main class="content"><article class="type-post entry has-post-thumbnail" aria-label="Report: Japan health authorities investigate Kobayashi Pharmaceutical factory after five deaths"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/dkirsh/" class="entry-author-link" rel="author"><span class="entry-author-name">Danielle Kirsh</span></a></span> | <time class="entry-time">April 1, 2024</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/report-japan-health-authorities-investigate-kobayashi-pharmaceutical-factory-after-five-deaths/">Report: Japan health authorities investigate Kobayashi Pharmaceutical factory after five deaths</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/report-japan-health-authorities-investigate-kobayashi-pharmaceutical-factory-after-five-deaths/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2024/04/kobayashi-logo-268x170.png" class="alignleft post-image entry-image wp-image-16280" alt="kobayashi pharmaceutical logo" decoding="async" /></a><p>Japanese health authorities searched a Kobayashi Pharmaceutical factory in Japan following reports of five deaths related to dietary supplements, Reuters reports. The plant inspection in western Japan is the second in recent days as health authorities inspected the company’s Osaka facility. In addition to the five reported deaths, there have been more than 100 hospitalizations…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="PBMs increasingly under fire in drug-pricing battle"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">September 6, 2023</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/drug-pricing-transparency-pbm-phrma/">PBMs increasingly under fire in drug-pricing battle</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/drug-pricing-transparency-pbm-phrma/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2023/09/AdobeStock_471633370-268x170.jpeg" class="alignleft post-image entry-image wp-image-16061" alt="Disposable syringe and American currency on black background" decoding="async" loading="lazy" /></a><p>As the national debate over drug pricing ramps up, Pharmacy Benefit Managers (PBMs) find themselves squarely in the spotlight. PhRMA, which has also criticized hospitals for marking up drug prices by as much as 500%, launched a seven-figure ad campaign targeting proposals in Congress to lower drug prices. PhRMA, which counts companies such as Pfizer,…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Timeline: Navigating Johnson & Johnson’s talc lawsuits and their stock performance impact"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">July 31, 2023</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/timeline-navigating-johnson-johnsons-talc-lawsuits-and-their-stock-performance-impact/">Timeline: Navigating Johnson & Johnson’s talc lawsuits and their stock performance impact</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/timeline-navigating-johnson-johnsons-talc-lawsuits-and-their-stock-performance-impact/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2021/03/johnson-johnson-1-768x499-3-268x170.jpg" class="alignleft post-image entry-image wp-image-14273" alt="Johnson & Johnson logo" decoding="async" loading="lazy" /></a><p>Johnson & Johnson continues to face legal challenges over allegations that its talcum powder causes cancer. Recently, a judge dismissed the company’s latest attempt to settle thousands of lawsuits through bankruptcy, marking the second time J&J’s bankruptcy strategy has been rebuffed. We take a look at the timeline of the talc litigation below. Johnson &…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="5 core trends in drug recalls: An analysis of 2022 and Q1 2023"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">April 20, 2023</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/drug-recalls-2022-2023-contamination-sterility-concerns/">5 core trends in drug recalls: An analysis of 2022 and Q1 2023</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/drug-recalls-2022-2023-contamination-sterility-concerns/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2023/04/AdobeStock_94355258-268x170.jpeg" class="alignleft post-image entry-image wp-image-15893" alt="pharmaceutical industry. Production line machine conveyor with glass bottles ampoules at factory" decoding="async" loading="lazy" /></a><p>Drug recalls surged in 2022, with defective pharmaceutical units reaching a five-year high, according to the Sedgwick 2023 State of the Nation Recall Index. Also in 2022, sterility was the top cause of recalls for the first time in more than six years. January 2023 saw a significant increase in the number of drug recalls…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="PRISM.science debuts new adverse-event monitoring tool"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">February 15, 2023</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/prism-science-debuts-adverse-event-monitoring-tool/">PRISM.science debuts new adverse-event monitoring tool</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/prism-science-debuts-adverse-event-monitoring-tool/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2023/02/prism-science-logo-2023-copy-268x170.gif" class="alignleft post-image entry-image wp-image-15811" alt="PRISM.Science" decoding="async" loading="lazy" /></a><p>PRISM.science, a biomedical database company, has launched a new product called AE Alert. The adverse event detection product provides comprehensive global literature surveillance to monitor adverse events related to prescription drugs. This product is designed to address the limitations of conventional pharmacovigilance literature surveillance by aggregating content in real-time. The company says AE Alert has…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Urgent U.S. recall issued for Global Pharma Healthcare eye drops"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">February 3, 2023</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/urgent-u-s-recall-issued-for-global-pharma-healthcare-eye-drops/">Urgent U.S. recall issued for Global Pharma Healthcare eye drops</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/urgent-u-s-recall-issued-for-global-pharma-healthcare-eye-drops/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2023/02/artificial-tears-268x170.jpg" class="alignleft post-image entry-image wp-image-15778" alt="artificial tears" decoding="async" loading="lazy" /></a><p>Global Pharma Healthcare is voluntarily recalling lubricant eye drops owing to potential contamination. The recall is a result of an investigation by the Centers for Disease Control and Prevention (CDC) into a cluster of multi-state infections linked to the use of the product. CDC suspects that a cluster of Verona Integron-mediated Metallo-β-lactamase (VIM)- and Guiana-Extended…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="10 prominent drugs recalled over nitrosamines"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">December 28, 2022</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/10-prominent-drugs-recalled-over-nitrosamines/">10 prominent drugs recalled over nitrosamines</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/10-prominent-drugs-recalled-over-nitrosamines/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2022/12/Pills_2-268x170.jpg" class="alignleft post-image entry-image wp-image-15725" alt="Pills" decoding="async" loading="lazy" /></a><p>In recent years, a number of drug companies have carried out prominent recalls of hypertension, heartburn and diabetes medications due to the presence of nitrosamines, organic compounds shown to cause cancer in animal studies. The problem could cost Big Pharma companies billions of dollars, but proving the cancer-causing role of nitrosamines in drugs may be difficult.…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Baxter issues Class 1 recall of Clearlink Basic Solution Sets with Duovent"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">September 15, 2022</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/baxter-issues-class-1-recall-of-clearlink-basic-solution-sets-with-duovent/">Baxter issues Class 1 recall of Clearlink Basic Solution Sets with Duovent</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/baxter-issues-class-1-recall-of-clearlink-basic-solution-sets-with-duovent/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2020/11/baxter-268x170.png" class="alignleft post-image entry-image wp-image-14020" alt="Baxter logo" decoding="async" loading="lazy" /></a><p>The FDA has classified a recall of a Baxter Healthcare product used to deliver hazardous drugs such as chemotherapeutic agents Class 1, indicating that it could cause serious adverse health consequences or death. The recall covers all lots with product code 2R8403 distributed from October 14, 2020 to June 30, 2022. There are Baxter announced…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="What’s behind the dip in pharma recalls in Q2 2022"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">August 25, 2022</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/whats-behind-the-dip-in-pharma-recalls-in-q2-2022/">What’s behind the dip in pharma recalls in Q2 2022</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/whats-behind-the-dip-in-pharma-recalls-in-q2-2022/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2022/08/pexels-karolina-grabowska-4210607-1-268x170.jpg" class="alignleft post-image entry-image wp-image-15518" alt="OTC pharmaceuticals" decoding="async" loading="lazy" /></a><p>In Q2 2022, the number of recalled units in the U.S. pharma industry dropped sharply. In the first quarter of the year, drug makers recalled more than 435 million units. However, the number of recalled units in Q2 2022 was 20.5 million, according to the Sedgwick Brand Protection Q2 2022 recall index. “It was definitely a…</p> </div><footer class="entry-footer"></footer></article><article class="type-post entry has-post-thumbnail" aria-label="Taro Pharmaceuticals announces Type I recall of Taro-zoledronic acid injection"><header class="entry-header"><p class="entry-meta"><span class="entry-author">By <a href="https://www.pharmaceuticalprocessingworld.com/author/bbuntz/" class="entry-author-link" rel="author"><span class="entry-author-name">Brian Buntz</span></a></span> | <time class="entry-time">August 11, 2022</time></p><h2 class="entry-title"><a class="entry-title-link" rel="bookmark" href="https://www.pharmaceuticalprocessingworld.com/taro-pharmaceuticals-announces-type-i-recall-of-taro-zoledronic-acid-injection/">Taro Pharmaceuticals announces Type I recall of Taro-zoledronic acid injection</a></h2> </header><div class="entry-content"><a class="entry-image-link" href="https://www.pharmaceuticalprocessingworld.com/taro-pharmaceuticals-announces-type-i-recall-of-taro-zoledronic-acid-injection/" aria-hidden="true" tabindex="-1"><img width="268" height="170" src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2022/08/taro-pharma-268x170.gif" class="alignleft post-image entry-image wp-image-15496" alt="Taro Pharmaceuticals" decoding="async" loading="lazy" /></a><p>The Canadian division of Taro Pharmaceuticals (NYSE:TARO) has announced a voluntary Type 1 recall of six lots of Taro-zoledronic Acid Injection. Type 1 recalls, according to Health Canada, refer to products that could cause serious adverse health consequences or death. It corresponds to Class 1 recalls from the FDA. Taro Pharmaceutical‘s consumer-level recall covers 5 mg/100…</p> </div><footer class="entry-footer"></footer></article><div class="archive-pagination pagination"><div class="pagination-next alignright"><a href="https://www.pharmaceuticalprocessingworld.com/category/recalls/page/2/" class="button">Next ></a></div></div></main><aside class="sidebar sidebar-primary widget-area" role="complementary" aria-label="Primary Sidebar"><section id="custom_html-11" class="widget_text widget widget_custom_html"><div class="widget_text widget-wrap"><div class="textwidget custom-html-widget"><center> <div style="display: flex; flex-direction: column; justify-content: center; width: 300px;"> <div align="center"><a href="https://www.pharmaceuticalprocessingworld.com/sign-up-for-the-pharmaceutical-processing-enewsletter/" target="_blank"><img src="https://www.pharmaceuticalprocessingworld.com/wp-content/uploads/2023/12/PharmaceuticalProcessing-300x100-1.jpg" alt=“ppw newsletter”></a></div> <div 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lo={weeks:{days:7,hours:168,minutes:10080,seconds:604800,milliseconds:6048e5},days:{hours:24,minutes:1440,seconds:86400,milliseconds:864e5},hours:{minutes:60,seconds:3600,milliseconds:36e5},minutes:{seconds:60,milliseconds:6e4},seconds:{milliseconds:1e3}},co=gn({years:{quarters:4,months:12,weeks:52,days:365,hours:8760,minutes:525600,seconds:31536e3,milliseconds:31536e6},quarters:{months:3,weeks:13,days:91,hours:2184,minutes:131040,seconds:7862400,milliseconds:78624e5},months:{weeks:4,days:30,hours:720,minutes:43200,seconds:2592e3,milliseconds:2592e6}},lo),fo=gn({years:{quarters:4,months:12,weeks:52.1775,days:365.2425,hours:8765.82,minutes:525949.2,seconds:31556952,milliseconds:31556952e3},quarters:{months:3,weeks:13.044375,days:91.310625,hours:2191.455,minutes:131487.3,seconds:7889238,milliseconds:7889238e3},months:{weeks:30.436875/7,days:30.436875,hours:730.485,minutes:43829.1,seconds:2629746,milliseconds:2629746e3}},lo),ho=["years","quarters","months","weeks","days","hours","minutes","seconds","milliseconds"],mo=ho.slice(0).reverse();function yo(e,t,n){void 0===n&&(n=!1);var r={values:n?t.values:gn({},e.values,t.values||{}),loc:e.loc.clone(t.loc),conversionAccuracy:t.conversionAccuracy||e.conversionAccuracy};return new po(r)}function vo(e,t,n,r,i){var o,s=e[i][n],u=t[n]/s,a=!(Math.sign(u)===Math.sign(r[i]))&&0!==r[i]&&Math.abs(u)<=1?(o=u)<0?Math.floor(o):Math.ceil(o):Math.trunc(u);r[i]+=a,t[n]-=a*s}var po=function(){function e(e){var t="longterm"===e.conversionAccuracy||!1;this.values=e.values,this.loc=e.loc||xi.create(),this.conversionAccuracy=t?"longterm":"casual",this.invalid=e.invalid||null,this.matrix=t?fo:co,this.isLuxonDuration=!0}e.fromMillis=function(t,n){return e.fromObject({milliseconds:t},n)},e.fromObject=function(t,n){if(void 0===n&&(n={}),null==t||"object"!=typeof t)throw new Fn("Duration.fromObject: argument expected to be an object, got "+(null===t?"null":typeof t));return new e({values:Mr(t,e.normalizeUnit),loc:xi.fromObject(n),conversionAccuracy:n.conversionAccuracy})},e.fromDurationLike=function(t){if(or(t))return e.fromMillis(t);if(e.isDuration(t))return t;if("object"==typeof t)return e.fromObject(t);throw new Fn("Unknown duration argument "+t+" of type "+typeof t)},e.fromISO=function(t,n){var r=Mi(t,[Pi,Yi])[0];return r?e.fromObject(r,n):e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.fromISOTime=function(t,n){var r=Mi(t,[ji,oo])[0];return r?e.fromObject(r,n):e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.invalid=function(t,n){if(void 0===n&&(n=null),!t)throw new Fn("need to specify a reason the Duration is invalid");var r=t instanceof Hr?t:new Hr(t,n);if(li.throwOnInvalid)throw new In(r);return new e({invalid:r})},e.normalizeUnit=function(e){var t={year:"years",years:"years",quarter:"quarters",quarters:"quarters",month:"months",months:"months",week:"weeks",weeks:"weeks",day:"days",days:"days",hour:"hours",hours:"hours",minute:"minutes",minutes:"minutes",second:"seconds",seconds:"seconds",millisecond:"milliseconds",milliseconds:"milliseconds"}[e?e.toLowerCase():e];if(!t)throw new Cn(e);return t},e.isDuration=function(e){return e&&e.isLuxonDuration||!1};var t=e.prototype;return t.toFormat=function(e,t){void 0===t&&(t={});var n=gn({},t,{floor:!1!==t.round&&!1!==t.floor});return this.isValid?Ur.create(this.loc,n).formatDurationFromString(this,e):"Invalid Duration"},t.toHuman=function(e){var t=this;void 0===e&&(e={});var n=ho.map((function(n){var r=t.values[n];return ir(r)?null:t.loc.numberFormatter(gn({style:"unit",unitDisplay:"long"},e,{unit:n.slice(0,-1)})).format(r)})).filter((function(e){return e}));return this.loc.listFormatter(gn({type:"conjunction",style:e.listStyle||"narrow"},e)).format(n)},t.toObject=function(){return this.isValid?gn({},this.values):{}},t.toISO=function(){if(!this.isValid)return null;var e="P";return 0!==this.years&&(e+=this.years+"Y"),0===this.months&&0===this.quarters||(e+=this.months+3*this.quarters+"M"),0!==this.weeks&&(e+=this.weeks+"W"),0!==this.days&&(e+=this.days+"D"),0===this.hours&&0===this.minutes&&0===this.seconds&&0===this.milliseconds||(e+="T"),0!==this.hours&&(e+=this.hours+"H"),0!==this.minutes&&(e+=this.minutes+"M"),0===this.seconds&&0===this.milliseconds||(e+=yr(this.seconds+this.milliseconds/1e3,3)+"S"),"P"===e&&(e+="T0S"),e},t.toISOTime=function(e){if(void 0===e&&(e={}),!this.isValid)return null;var t=this.toMillis();if(t<0||t>=864e5)return null;e=gn({suppressMilliseconds:!1,suppressSeconds:!1,includePrefix:!1,format:"extended"},e);var n=this.shiftTo("hours","minutes","seconds","milliseconds"),r="basic"===e.format?"hhmm":"hh:mm";e.suppressSeconds&&0===n.seconds&&0===n.milliseconds||(r+="basic"===e.format?"ss":":ss",e.suppressMilliseconds&&0===n.milliseconds||(r+=".SSS"));var i=n.toFormat(r);return e.includePrefix&&(i="T"+i),i},t.toJSON=function(){return this.toISO()},t.toString=function(){return this.toISO()},t.toMillis=function(){return this.as("milliseconds")},t.valueOf=function(){return this.toMillis()},t.plus=function(t){if(!this.isValid)return this;for(var n,r=e.fromDurationLike(t),i={},o=Dn(ho);!(n=o()).done;){var s=n.value;(lr(r.values,s)||lr(this.values,s))&&(i[s]=r.get(s)+this.get(s))}return yo(this,{values:i},!0)},t.minus=function(t){if(!this.isValid)return this;var n=e.fromDurationLike(t);return this.plus(n.negate())},t.mapUnits=function(e){if(!this.isValid)return this;for(var t={},n=0,r=Object.keys(this.values);n<r.length;n++){var i=r[n];t[i]=Tr(e(this.values[i],i))}return yo(this,{values:t},!0)},t.get=function(t){return this[e.normalizeUnit(t)]},t.set=function(t){return this.isValid?yo(this,{values:gn({},this.values,Mr(t,e.normalizeUnit))}):this},t.reconfigure=function(e){var t=void 0===e?{}:e,n=t.locale,r=t.numberingSystem,i=t.conversionAccuracy,o={loc:this.loc.clone({locale:n,numberingSystem:r})};return i&&(o.conversionAccuracy=i),yo(this,o)},t.as=function(e){return this.isValid?this.shiftTo(e).get(e):NaN},t.normalize=function(){if(!this.isValid)return this;var e=this.toObject();return function(e,t){mo.reduce((function(n,r){return ir(t[r])?n:(n&&vo(e,t,n,t,r),r)}),null)}(this.matrix,e),yo(this,{values:e},!0)},t.shiftTo=function(){for(var t=arguments.length,n=new Array(t),r=0;r<t;r++)n[r]=arguments[r];if(!this.isValid)return this;if(0===n.length)return this;n=n.map((function(t){return e.normalizeUnit(t)}));for(var i,o,s={},u={},a=this.toObject(),l=Dn(ho);!(o=l()).done;){var c=o.value;if(n.indexOf(c)>=0){i=c;var f=0;for(var d in u)f+=this.matrix[d][c]*u[d],u[d]=0;or(a[c])&&(f+=a[c]);var h=Math.trunc(f);for(var m in s[c]=h,u[c]=(1e3*f-1e3*h)/1e3,a)ho.indexOf(m)>ho.indexOf(c)&&vo(this.matrix,a,m,s,c)}else or(a[c])&&(u[c]=a[c])}for(var y in u)0!==u[y]&&(s[i]+=y===i?u[y]:u[y]/this.matrix[i][y]);return yo(this,{values:s},!0).normalize()},t.negate=function(){if(!this.isValid)return this;for(var e={},t=0,n=Object.keys(this.values);t<n.length;t++){var r=n[t];e[r]=0===this.values[r]?0:-this.values[r]}return yo(this,{values:e},!0)},t.equals=function(e){if(!this.isValid||!e.isValid)return!1;if(!this.loc.equals(e.loc))return!1;for(var t,n=Dn(ho);!(t=n()).done;){var r=t.value;if(i=this.values[r],o=e.values[r],!(void 0===i||0===i?void 0===o||0===o:i===o))return!1}var i,o;return!0},pn(e,[{key:"locale",get:function(){return this.isValid?this.loc.locale:null}},{key:"numberingSystem",get:function(){return this.isValid?this.loc.numberingSystem:null}},{key:"years",get:function(){return this.isValid?this.values.years||0:NaN}},{key:"quarters",get:function(){return this.isValid?this.values.quarters||0:NaN}},{key:"months",get:function(){return this.isValid?this.values.months||0:NaN}},{key:"weeks",get:function(){return this.isValid?this.values.weeks||0:NaN}},{key:"days",get:function(){return this.isValid?this.values.days||0:NaN}},{key:"hours",get:function(){return this.isValid?this.values.hours||0:NaN}},{key:"minutes",get:function(){return this.isValid?this.values.minutes||0:NaN}},{key:"seconds",get:function(){return this.isValid?this.values.seconds||0:NaN}},{key:"milliseconds",get:function(){return this.isValid?this.values.milliseconds||0:NaN}},{key:"isValid",get:function(){return null===this.invalid}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}}]),e}();var go=function(){function e(e){this.s=e.start,this.e=e.end,this.invalid=e.invalid||null,this.isLuxonInterval=!0}e.invalid=function(t,n){if(void 0===n&&(n=null),!t)throw new Fn("need to specify a reason the Interval is invalid");var r=t instanceof Hr?t:new Hr(t,n);if(li.throwOnInvalid)throw new _n(r);return new e({invalid:r})},e.fromDateTimes=function(t,n){var r=gs(t),i=gs(n),o=function(e,t){return e&&e.isValid?t&&t.isValid?t<e?go.invalid("end before start","The end of an interval must be after its start, but you had start="+e.toISO()+" and end="+t.toISO()):null:go.invalid("missing or invalid end"):go.invalid("missing or invalid start")}(r,i);return null==o?new e({start:r,end:i}):o},e.after=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i,i.plus(r))},e.before=function(t,n){var r=po.fromDurationLike(n),i=gs(t);return e.fromDateTimes(i.minus(r),i)},e.fromISO=function(t,n){var r=(t||"").split("/",2),i=r[0],o=r[1];if(i&&o){var s,u,a,l;try{u=(s=ps.fromISO(i,n)).isValid}catch(e){u=!1}try{l=(a=ps.fromISO(o,n)).isValid}catch(e){l=!1}if(u&&l)return e.fromDateTimes(s,a);if(u){var c=po.fromISO(o,n);if(c.isValid)return e.after(s,c)}else if(l){var f=po.fromISO(i,n);if(f.isValid)return e.before(a,f)}}return e.invalid("unparsable",'the input "'+t+"\" can't be parsed as ISO 8601")},e.isInterval=function(e){return e&&e.isLuxonInterval||!1};var t=e.prototype;return t.length=function(e){return void 0===e&&(e="milliseconds"),this.isValid?this.toDuration.apply(this,[e]).get(e):NaN},t.count=function(e){if(void 0===e&&(e="milliseconds"),!this.isValid)return NaN;var t=this.start.startOf(e),n=this.end.startOf(e);return Math.floor(n.diff(t,e).get(e))+1},t.hasSame=function(e){return!!this.isValid&&(this.isEmpty()||this.e.minus(1).hasSame(this.s,e))},t.isEmpty=function(){return this.s.valueOf()===this.e.valueOf()},t.isAfter=function(e){return!!this.isValid&&this.s>e},t.isBefore=function(e){return!!this.isValid&&this.e<=e},t.contains=function(e){return!!this.isValid&&(this.s<=e&&this.e>e)},t.set=function(t){var n=void 0===t?{}:t,r=n.start,i=n.end;return this.isValid?e.fromDateTimes(r||this.s,i||this.e):this},t.splitAt=function(){var t=this;if(!this.isValid)return[];for(var n=arguments.length,r=new Array(n),i=0;i<n;i++)r[i]=arguments[i];for(var o=r.map(gs).filter((function(e){return t.contains(e)})).sort(),s=[],u=this.s,a=0;u<this.e;){var l=o[a]||this.e,c=+l>+this.e?this.e:l;s.push(e.fromDateTimes(u,c)),u=c,a+=1}return s},t.splitBy=function(t){var n=po.fromDurationLike(t);if(!this.isValid||!n.isValid||0===n.as("milliseconds"))return[];for(var r,i=this.s,o=1,s=[];i<this.e;){var u=this.start.plus(n.mapUnits((function(e){return e*o})));r=+u>+this.e?this.e:u,s.push(e.fromDateTimes(i,r)),i=r,o+=1}return s},t.divideEqually=function(e){return this.isValid?this.splitBy(this.length()/e).slice(0,e):[]},t.overlaps=function(e){return this.e>e.s&&this.s<e.e},t.abutsStart=function(e){return!!this.isValid&&+this.e==+e.s},t.abutsEnd=function(e){return!!this.isValid&&+e.e==+this.s},t.engulfs=function(e){return!!this.isValid&&(this.s<=e.s&&this.e>=e.e)},t.equals=function(e){return!(!this.isValid||!e.isValid)&&(this.s.equals(e.s)&&this.e.equals(e.e))},t.intersection=function(t){if(!this.isValid)return this;var n=this.s>t.s?this.s:t.s,r=this.e<t.e?this.e:t.e;return n>=r?null:e.fromDateTimes(n,r)},t.union=function(t){if(!this.isValid)return this;var n=this.s<t.s?this.s:t.s,r=this.e>t.e?this.e:t.e;return e.fromDateTimes(n,r)},e.merge=function(e){var t=e.sort((function(e,t){return e.s-t.s})).reduce((function(e,t){var n=e[0],r=e[1];return r?r.overlaps(t)||r.abutsStart(t)?[n,r.union(t)]:[n.concat([r]),t]:[n,t]}),[[],null]),n=t[0],r=t[1];return r&&n.push(r),n},e.xor=function(t){for(var n,r,i=null,o=0,s=[],u=t.map((function(e){return[{time:e.s,type:"s"},{time:e.e,type:"e"}]})),a=Dn((n=Array.prototype).concat.apply(n,u).sort((function(e,t){return e.time-t.time})));!(r=a()).done;){var l=r.value;1===(o+="s"===l.type?1:-1)?i=l.time:(i&&+i!=+l.time&&s.push(e.fromDateTimes(i,l.time)),i=null)}return e.merge(s)},t.difference=function(){for(var t=this,n=arguments.length,r=new Array(n),i=0;i<n;i++)r[i]=arguments[i];return e.xor([this].concat(r)).map((function(e){return t.intersection(e)})).filter((function(e){return e&&!e.isEmpty()}))},t.toString=function(){return this.isValid?"["+this.s.toISO()+" – "+this.e.toISO()+")":"Invalid Interval"},t.toISO=function(e){return this.isValid?this.s.toISO(e)+"/"+this.e.toISO(e):"Invalid Interval"},t.toISODate=function(){return this.isValid?this.s.toISODate()+"/"+this.e.toISODate():"Invalid Interval"},t.toISOTime=function(e){return this.isValid?this.s.toISOTime(e)+"/"+this.e.toISOTime(e):"Invalid Interval"},t.toFormat=function(e,t){var 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e({invalid:r})},e.isDateTime=function(e){return e&&e.isLuxonDateTime||!1};var t=e.prototype;return t.get=function(e){return this[e]},t.resolvedLocaleOptions=function(e){void 0===e&&(e={});var t=Ur.create(this.loc.clone(e),e).resolvedOptions(this);return{locale:t.locale,numberingSystem:t.numberingSystem,outputCalendar:t.calendar}},t.toUTC=function(e,t){return void 0===e&&(e=0),void 0===t&&(t={}),this.setZone(ei.instance(e),t)},t.toLocal=function(){return this.setZone(li.defaultZone)},t.setZone=function(t,n){var r=void 0===n?{}:n,i=r.keepLocalTime,o=void 0!==i&&i,s=r.keepCalendarTime,u=void 0!==s&&s;if((t=ni(t,li.defaultZone)).equals(this.zone))return this;if(t.isValid){var a=this.ts;if(o||u){var l=t.offset(this.ts);a=ts(this.toObject(),l,t)[0]}return Ko(this,{ts:a,zone:t})}return e.invalid($o(t))},t.reconfigure=function(e){var t=void 0===e?{}:e,n=t.locale,r=t.numberingSystem,i=t.outputCalendar;return Ko(this,{loc:this.loc.clone({locale:n,numberingSystem:r,outputCalendar:i})})},t.setLocale=function(e){return this.reconfigure({locale:e})},t.set=function(e){if(!this.isValid)return this;var t,n=Mr(e,hs),r=!ir(n.weekYear)||!ir(n.weekNumber)||!ir(n.weekday),i=!ir(n.ordinal),o=!ir(n.year),s=!ir(n.month)||!ir(n.day),u=o||s,a=n.weekYear||n.weekNumber;if((u||i)&&a)throw new Vn("Can't mix weekYear/weekNumber units with year/month/day or ordinals");if(s&&i)throw new Vn("Can't mix ordinal dates with month/day");r?t=Ho(gn({},Uo(this.c),n)):ir(n.ordinal)?(t=gn({},this.toObject(),n),ir(n.day)&&(t.day=Math.min(gr(t.year,t.month),t.day))):t=Go(gn({},Ro(this.c),n));var l=ts(t,this.o,this.zone);return Ko(this,{ts:l[0],o:l[1]})},t.plus=function(e){return this.isValid?Ko(this,ns(this,po.fromDurationLike(e))):this},t.minus=function(e){return this.isValid?Ko(this,ns(this,po.fromDurationLike(e).negate())):this},t.startOf=function(e){if(!this.isValid)return this;var t={},n=po.normalizeUnit(e);switch(n){case"years":t.month=1;case"quarters":case"months":t.day=1;case"weeks":case"days":t.hour=0;case"hours":t.minute=0;case"minutes":t.second=0;case"seconds":t.millisecond=0}if("weeks"===n&&(t.weekday=1),"quarters"===n){var r=Math.ceil(this.month/3);t.month=3*(r-1)+1}return this.set(t)},t.endOf=function(e){var t;return this.isValid?this.plus((t={},t[e]=1,t)).startOf(e).minus(1):this},t.toFormat=function(e,t){return void 0===t&&(t={}),this.isValid?Ur.create(this.loc.redefaultToEN(t)).formatDateTimeFromString(this,e):"Invalid DateTime"},t.toLocaleString=function(e,t){return void 0===e&&(e=An),void 0===t&&(t={}),this.isValid?Ur.create(this.loc.clone(t),e).formatDateTime(this):"Invalid DateTime"},t.toLocaleParts=function(e){return void 0===e&&(e={}),this.isValid?Ur.create(this.loc.clone(e),e).formatDateTimeParts(this):[]},t.toISO=function(e){var t=void 0===e?{}:e,n=t.format,r=void 0===n?"extended":n,i=t.suppressSeconds,o=void 0!==i&&i,s=t.suppressMilliseconds,u=void 0!==s&&s,a=t.includeOffset,l=void 0===a||a,c=t.extendedZone,f=void 0!==c&&c;if(!this.isValid)return null;var d="extended"===r,h=os(this,d);return h+="T",h+=ss(this,d,o,u,l,f)},t.toISODate=function(e){var t=(void 0===e?{}:e).format,n=void 0===t?"extended":t;return this.isValid?os(this,"extended"===n):null},t.toISOWeekDate=function(){return is(this,"kkkk-'W'WW-c")},t.toISOTime=function(e){var t=void 0===e?{}:e,n=t.suppressMilliseconds,r=void 0!==n&&n,i=t.suppressSeconds,o=void 0!==i&&i,s=t.includeOffset,u=void 0===s||s,a=t.includePrefix,l=void 0!==a&&a,c=t.extendedZone,f=void 0!==c&&c,d=t.format,h=void 0===d?"extended":d;return this.isValid?(l?"T":"")+ss(this,"extended"===h,o,r,u,f):null},t.toRFC2822=function(){return is(this,"EEE, dd LLL yyyy HH:mm:ss ZZZ",!1)},t.toHTTP=function(){return is(this.toUTC(),"EEE, dd LLL yyyy HH:mm:ss 'GMT'")},t.toSQLDate=function(){return this.isValid?os(this,!0):null},t.toSQLTime=function(e){var t=void 0===e?{}:e,n=t.includeOffset,r=void 0===n||n,i=t.includeZone,o=void 0!==i&&i,s=t.includeOffsetSpace,u="HH:mm:ss.SSS";return(o||r)&&((void 0===s||s)&&(u+=" "),o?u+="z":r&&(u+="ZZ")),is(this,u,!0)},t.toSQL=function(e){return void 0===e&&(e={}),this.isValid?this.toSQLDate()+" "+this.toSQLTime(e):null},t.toString=function(){return this.isValid?this.toISO():"Invalid DateTime"},t.valueOf=function(){return this.toMillis()},t.toMillis=function(){return this.isValid?this.ts:NaN},t.toSeconds=function(){return this.isValid?this.ts/1e3:NaN},t.toUnixInteger=function(){return this.isValid?Math.floor(this.ts/1e3):NaN},t.toJSON=function(){return this.toISO()},t.toBSON=function(){return this.toJSDate()},t.toObject=function(e){if(void 0===e&&(e={}),!this.isValid)return{};var t=gn({},this.c);return e.includeConfig&&(t.outputCalendar=this.outputCalendar,t.numberingSystem=this.loc.numberingSystem,t.locale=this.loc.locale),t},t.toJSDate=function(){return new Date(this.isValid?this.ts:NaN)},t.diff=function(e,t,n){if(void 0===t&&(t="milliseconds"),void 0===n&&(n={}),!this.isValid||!e.isValid)return po.invalid("created by diffing an invalid DateTime");var r,i=gn({locale:this.locale,numberingSystem:this.numberingSystem},n),o=(r=t,Array.isArray(r)?r:[r]).map(po.normalizeUnit),s=e.valueOf()>this.valueOf(),u=bo(s?this:e,s?e:this,o,i);return s?u.negate():u},t.diffNow=function(t,n){return void 0===t&&(t="milliseconds"),void 0===n&&(n={}),this.diff(e.now(),t,n)},t.until=function(e){return this.isValid?go.fromDateTimes(this,e):this},t.hasSame=function(e,t){if(!this.isValid)return!1;var n=e.valueOf(),r=this.setZone(e.zone,{keepLocalTime:!0});return r.startOf(t)<=n&&n<=r.endOf(t)},t.equals=function(e){return this.isValid&&e.isValid&&this.valueOf()===e.valueOf()&&this.zone.equals(e.zone)&&this.loc.equals(e.loc)},t.toRelative=function(t){if(void 0===t&&(t={}),!this.isValid)return null;var n=t.base||e.fromObject({},{zone:this.zone}),r=t.padding?this<n?-t.padding:t.padding:0,i=["years","months","days","hours","minutes","seconds"],o=t.unit;return Array.isArray(t.unit)&&(i=t.unit,o=void 0),ys(n,this.plus(r),gn({},t,{numeric:"always",units:i,unit:o}))},t.toRelativeCalendar=function(t){return void 0===t&&(t={}),this.isValid?ys(t.base||e.fromObject({},{zone:this.zone}),this,gn({},t,{numeric:"auto",units:["years","months","days"],calendary:!0})):null},e.min=function(){for(var t=arguments.length,n=new Array(t),r=0;r<t;r++)n[r]=arguments[r];if(!n.every(e.isDateTime))throw new Fn("min requires all arguments be DateTimes");return ar(n,(function(e){return e.valueOf()}),Math.min)},e.max=function(){for(var t=arguments.length,n=new Array(t),r=0;r<t;r++)n[r]=arguments[r];if(!n.every(e.isDateTime))throw new Fn("max requires all arguments be DateTimes");return ar(n,(function(e){return e.valueOf()}),Math.max)},e.fromFormatExplain=function(e,t,n){void 0===n&&(n={});var r=n,i=r.locale,o=void 0===i?null:i,s=r.numberingSystem,u=void 0===s?null:s;return Lo(xi.fromOpts({locale:o,numberingSystem:u,defaultToEN:!0}),e,t)},e.fromStringExplain=function(t,n,r){return void 0===r&&(r={}),e.fromFormatExplain(t,n,r)},pn(e,[{key:"isValid",get:function(){return null===this.invalid}},{key:"invalidReason",get:function(){return this.invalid?this.invalid.reason:null}},{key:"invalidExplanation",get:function(){return this.invalid?this.invalid.explanation:null}},{key:"locale",get:function(){return this.isValid?this.loc.locale:null}},{key:"numberingSystem",get:function(){return this.isValid?this.loc.numberingSystem:null}},{key:"outputCalendar",get:function(){return this.isValid?this.loc.outputCalendar:null}},{key:"zone",get:function(){return this._zone}},{key:"zoneName",get:function(){return this.isValid?this.zone.name:null}},{key:"year",get:function(){return this.isValid?this.c.year:NaN}},{key:"quarter",get:function(){return this.isValid?Math.ceil(this.c.month/3):NaN}},{key:"month",get:function(){return this.isValid?this.c.month:NaN}},{key:"day",get:function(){return this.isValid?this.c.day:NaN}},{key:"hour",get:function(){return this.isValid?this.c.hour:NaN}},{key:"minute",get:function(){return this.isValid?this.c.minute:NaN}},{key:"second",get:function(){return this.isValid?this.c.second:NaN}},{key:"millisecond",get:function(){return this.isValid?this.c.millisecond:NaN}},{key:"weekYear",get:function(){return this.isValid?Qo(this).weekYear:NaN}},{key:"weekNumber",get:function(){return this.isValid?Qo(this).weekNumber:NaN}},{key:"weekday",get:function(){return this.isValid?Qo(this).weekday:NaN}},{key:"ordinal",get:function(){return this.isValid?Ro(this.c).ordinal:NaN}},{key:"monthShort",get:function(){return this.isValid?wo.months("short",{locObj:this.loc})[this.month-1]:null}},{key:"monthLong",get:function(){return this.isValid?wo.months("long",{locObj:this.loc})[this.month-1]:null}},{key:"weekdayShort",get:function(){return this.isValid?wo.weekdays("short",{locObj:this.loc})[this.weekday-1]:null}},{key:"weekdayLong",get:function(){return this.isValid?wo.weekdays("long",{locObj:this.loc})[this.weekday-1]:null}},{key:"offset",get:function(){return this.isValid?+this.o:NaN}},{key:"offsetNameShort",get:function(){return this.isValid?this.zone.offsetName(this.ts,{format:"short",locale:this.locale}):null}},{key:"offsetNameLong",get:function(){return this.isValid?this.zone.offsetName(this.ts,{format:"long",locale:this.locale}):null}},{key:"isOffsetFixed",get:function(){return this.isValid?this.zone.isUniversal:null}},{key:"isInDST",get:function(){return!this.isOffsetFixed&&(this.offset>this.set({month:1,day:1}).offset||this.offset>this.set({month:5}).offset)}},{key:"isInLeapYear",get:function(){return vr(this.year)}},{key:"daysInMonth",get:function(){return 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$n}},{key:"DATETIME_MED",get:function(){return Qn}},{key:"DATETIME_MED_WITH_SECONDS",get:function(){return Kn}},{key:"DATETIME_MED_WITH_WEEKDAY",get:function(){return Xn}},{key:"DATETIME_FULL",get:function(){return er}},{key:"DATETIME_FULL_WITH_SECONDS",get:function(){return tr}},{key:"DATETIME_HUGE",get:function(){return nr}},{key:"DATETIME_HUGE_WITH_SECONDS",get:function(){return rr}}]),e}();function gs(e){if(ps.isDateTime(e))return e;if(e&&e.valueOf&&or(e.valueOf()))return ps.fromJSDate(e);if(e&&"object"==typeof e)return ps.fromObject(e);throw new Fn("Unknown datetime argument: "+e+", of type "+typeof e)}yn.DateTime=ps,yn.Duration=po,yn.FixedOffsetZone=ei,yn.IANAZone=Kr,yn.Info=wo,yn.Interval=go,yn.InvalidZone=ti,yn.Settings=li,yn.SystemZone=Jr,yn.VERSION="2.4.0",yn.Zone=Rr;const ws=new XMLHttpRequest;ws.onreadystatechange=function(){if(4===this.readyState&&200===this.status){let e=JSON.parse(this.responseText).intradayPricing,t=0,n=yn.DateTime.now();e.length>0&&(t=parseFloat(e[e.length-1].price).toFixed(2),n=yn.DateTime.fromISO(e[e.length-1].time));document.getElementById("md-current-price").innerHTML="$"+t;document.getElementById("md-current-time").innerHTML=n.toLocaleString(yn.DateTime.DATETIME_FULL);const r=[],i=[];e.forEach((e=>{const{price:t,time:n}=e,o=yn.DateTime.fromISO(n),s=parseFloat(t).toFixed(2);r.push(o.toUnixInteger()),i.push(s)}));const o=document.getElementById("md-intraday-chart"),s=new mn({width:300,height:120,class:"spark",pxAlign:!1,cursor:{show:!1},select:{show:!1},legend:{show:!1},scales:{x:{time:!1}},axes:[{show:!1},{show:!1}],series:[{},{stroke:"#ec5b2e",fill:"#ffb39c"}]},[r,i]).ctx.canvas;o.parentNode.append(s)}},ws.open("GET","https://medtech100.com/md100/json/pricing",!0),ws.send(); //# sourceMappingURL=index.80f28a61.js.map </script> </head> <body> <div id="md-tech-ad"> <table class="md-table" align="center" cellpadding="0" cellspacing="0" width="100%"> <tr> <td width="100%"> <div class="md-align"> <img id="md-logo" class="md-margin" src="https://images.designworldonline.com/newsletters/images/ee034d8d8274c1ee5e8111f11cf1be49.png" alt="Medtech 100 logo"> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align"> <div class="margin-text"> <span style="font-weight:600;color:#e06636!important;font-size:16px!important;line-height:14px!important"> Market Summary > Current Price </span> </div> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align" id="md-content-container"> <div id="md-current-price"></div> <div id="md-current-time"></div> <div id="md-chart-container"> <div id="md-intraday-chart"></div> </div> </div> </td> </tr> <tr> <td width="100%"> <div class="md-align"> <div class="md-margin-text"> <span style="font-size:13px;line-height:15px!important"> The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing. </span> </div> </div> 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