Publications - Proteome Sciences

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post-translational modified, homocitrullinated peptides induces CD8 T-cell responses that mediate antitumor immunity</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/srm">SRM </a> Assay Development </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Sabaria Shah, Katherine W Cook, Peter Symonds, Juliane Weißer, Anne Skinner, Abdullah Al Omari, Samantha J Paston, Ian Pike, Lindy G Durrant and Victoria A Brentville </div> <div> <span class="u-darkerText">Publisher:</span> Journal for ImmunoTherapy of Cancer 2023;11:e006966. doi: 10.1136/jitc-2023-006966 </div> <div> <span class="u-darkerText">Date:</span> October 2023 </div> </div> <a class="Button u-margBottom4" href="https://jitc.bmj.com/content/11/10/e006966#" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,32" data-tag=""> <h2 class="u-redlineLeftSm">Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPP尾 levels in cerebrospinal fluid and 2D/3D cell culture models</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Wittrahm R, Takalo M, Kuulasmaa T, Mäkinen PM, Mäkinen P, Kon膷arevi膰 S, Fartzdinov V, Selzer S, Kokkola T, Antikainen L, Martiskainen H, Kemppainen S, Marttinen M, Jeskanen H, Rostalski H, Rahunen E, Kivipelto M, Ngandu T, Natunen T, Lambert JC, Tanzi RE, Kim DY, Rauramaa T, Herukka SK, Soininen H, Laakso M, Pike I, Leinonen V, Haapasalo A, Hiltunen M. </div> <div> <span class="u-darkerText">Publisher:</span> Neurobiol Dis. 182:106140. doi: 10.1016/j.nbd.2023.106140. Epub 2023 Apr 28. PMID: 37120095. </div> <div> <span class="u-darkerText">Date:</span> June 2023 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/37120095/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag=""> <h2 class="u-redlineLeftSm">Cerebrospinal fluid and brain proteoforms of the granin neuropeptide Family in Alzheimer's disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Quinn JP., Ethier EC., Novielli A., Malone A., Ramirez CE., Salloum L., Trombetta BA., Kivisäkk P., Bremang M., Selzer S., Fournier M., Das S., Xing Y., Arnold SE., Carlyle BC. </div> <div> <span class="u-darkerText">Publisher:</span> J Am Soc Mass Spectrom doi 10.1021/jasms.2c00341 </div> <div> <span class="u-darkerText">Date:</span> March 2023 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/36912488/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,7,32" data-tag=""> <h2 class="u-redlineLeftSm">S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span>, <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Ferreira CB, Marttinen M, Coelho JE, Paldanius KMA, Takalo M, Mäkinen P, Leppänen L, Miranda-Lourenço C, Fonseca-Gomes J, Tanqueiro SR, Vaz SH, Belo RF, Sebastião AM, Leinonen V, Soininen H, Pike I, Haapasalo A, Lopes LV, de Mendonça A, Diógenes MJ, Hiltunen M. </div> <div> <span class="u-darkerText">Publisher:</span> Neurobiol Dis.; 163:105603. doi: 10.1016/j.nbd.2021.105603. Epub 2021 Dec 24. PMID: 34954322. </div> <div> <span class="u-darkerText">Date:</span> February 2022 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/34954322/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,7,32" data-tag=""> <h2 class="u-redlineLeftSm">Preclinical and clinical biomarker studies of CT1812: A novel approach to Alzheimer's disease modification.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span>, <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Izzo NJ, Yuede CM, LaBarbera KM, Limegrover CS, Rehak C, Yurko R, Waybright L, Look G, Rishton G, Safferstein H, Hamby ME, Williams C, Sadlek K, Edwards HM, Davis CS, Grundman M, Schneider LS, DeKosky ST, Chelsky D, Pike I, Henstridge C, Blennow K, Zetterberg H, LeVine H 3rd, Spires-Jones TL, Cirrito JR, Catalano SM. </div> <div> <span class="u-darkerText">Publisher:</span> Alzheimers Dement. 2021 Aug;17(8):1365-1382. doi: 10.1002/alz.12302. Epub 2021 Feb 8. PMID: 33559354; PMCID: PMC8349378. </div> <div> <span class="u-darkerText">Date:</span> August 2021 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/33559354/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,33" data-tag=""> <h2 class="u-redlineLeftSm">Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/srm">SRM </a> Assay Development </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Panitz V, Kon膷arevi膰 S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA. </div> <div> <span class="u-darkerText">Publisher:</span> Theranostics. 2021 Sep 3;11(19):9217-9233. doi: 10.7150/thno.60679. PMID: 34646367; PMCID: PMC8490504. </div> <div> <span class="u-darkerText">Date:</span> September 2021 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/34646367/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="32" data-tag=""> <h2 class="u-redlineLeftSm">Analysis of circulating protein aggregates as a route of investigation into neurodegenerative disorders</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Adiutori R, Puentes F, Bremang M, Lombardi V, Zubiri I, Leoni E, Aarum J, Sheer D, McArthur S, Pike I, Malaspina A. </div> <div> <span class="u-darkerText">Publisher:</span> Brain Commun. 2021 Jul 9;3(3):fcab148. doi: 10.1093/braincomms/fcab148. PMID: 34396108; PMCID: PMC8361415. </div> <div> <span class="u-darkerText">Date:</span> July 2021 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/34396108/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,7,18,32,10" data-tag=""> <h2 class="u-redlineLeftSm">TMTpro 18plex: The expanded and complete set of TMTpro reagents for sample multiplexing</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span>, <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span>, <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span>, <span class="u-textNoWrap"><a href="/services/tmt-ms3-workflow">TMT-MS3</a> quantitative proteomics </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Li J, Cai Z, Bomgarden RD, Pike I, Kuhn K, Rogers JC, Roberts TM, Gygi SP, Paulo JA. </div> <div> <span class="u-darkerText">Publisher:</span> J Proteome Res. 2021 May 7;20(5):2964-2972. doi: 10.1021/acs.jproteome.1c00168. Epub 2021 Apr 26. PMID: 33900084; PMCID: PMC8210943. </div> <div> <span class="u-darkerText">Date:</span> May 2021 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/33900084/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,32" data-tag=""> <h2 class="u-redlineLeftSm">Alzheimer's genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Eysert F, Coulon A, Boscher E, Vreulx AC, Flaig A, Mendes T, Hughes S, Grenier-Boley B, Hanoulle X, Demiautte F, Bauer C, Marttinen M, Takalo M, Amouyel P, Desai S, Pike I, Hiltunen M, Chécler F, Farinelli M, Delay C, Malmanche N, Hébert SS, Dumont J, Kilinc D, Lambert JC, Chapuis J. </div> <div> <span class="u-darkerText">Publisher:</span> Mol Psychiatry. 2021 Oct;26(10):5592-5607. doi: 10.1038/s41380-020-00926-w. Epub 2020 Nov 3. Erratum in: Mol Psychiatry. 2021 Jan 4;: PMID: 33144711; PMCID: PMC8758496. </div> <div> <span class="u-darkerText">Date:</span> October 2021 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/33144711/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,18" data-tag=""> <h2 class="u-redlineLeftSm">TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Li J, Van Vranken JG, Pontano Vaites L, Schweppe DK, Huttlin EL, Etienne C, Nandhikonda P, Viner R, Robitaille AM, Thompson AH, Kuhn K, Pike I, Bomgarden RD, Rogers JC, Gygi SP, Paulo JA. </div> <div> <span class="u-darkerText">Publisher:</span> Nat Methods. 2020 Apr;17(4):399-404. doi: 10.1038/s41592-020-0781-4. Epub 2020 Mar 16. PMID: 32203386; PMCID: PMC7302421. </div> <div> <span class="u-darkerText">Date:</span> April 2020 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/32203386" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,16" data-tag=""> <h2 class="u-redlineLeftSm">Combined tissue-fluid proteomics to unravel phenotypic variability in Amyotrophic Lateral Sclerosis</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/tmtcalibrator-workflow">TMTcalibrator</a> tissue-enhanced fluid proteomics </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Leoni E, Bremang M, Mitra V, Zubiri I, Jung S, Lu CH, Adiutori R, Lombardi V, Russell C, Koncarevic S, Ward M, Pike I, Malaspina A. </div> <div> <span class="u-darkerText">Publisher:</span> Sci Rep. 2019 Mar 14;9(1):4478. doi: 10.1038/s41598-019-40632-4. Erratum in: Sci Rep. 2020 Oct 23;10(1):18603. PMID: 30872628; PMCID: PMC6418138. </div> <div> <span class="u-darkerText">Date:</span> March 2019 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/30872628/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="18" data-tag=""> <h2 class="u-redlineLeftSm">TMTpro: Design, synthesis, and initial evaluation of a proline-based Isobaric 16-plex Tandem Mass Tag reagent set</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Thompson A, Wölmer N, Koncarevic S, Selzer S, Böhm G, Legner H, Schmid P, Kienle S, Penning P, Höhle C, Berfelde A, Martinez-Pinna R, Farztdinov V, Jung S, Kuhn K, Pike I. </div> <div> <span class="u-darkerText">Publisher:</span> Anal Chem. 2019 Dec 17;91(24):15941-15950. doi: 10.1021/acs.analchem.9b04474. Epub 2019 Dec 3. PMID: 31738517. </div> <div> <span class="u-darkerText">Date:</span> December 2019 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/31738517/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,32" data-tag=""> <h2 class="u-redlineLeftSm">Quantitative proteomics of breast tumors: Tissue quality assessment to clinical biomarkers</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Chen Y, Britton D, Wood ER, Brantley S, Magliocco A, Pike I, Koomen JM. </div> <div> <span class="u-darkerText">Publisher:</span> Proteomics. 2017 Mar;17(6):10.1002/pmic.201600335. doi: 10.1002/pmic.201600335. PMID: 28127872; PMCID: PMC5996774. </div> <div> <span class="u-darkerText">Date:</span> March 2017 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/28127872/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,16" data-tag=""> <h2 class="u-redlineLeftSm">Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/tmtcalibrator-workflow">TMTcalibrator</a> tissue-enhanced fluid proteomics </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Magdalinou NK, Noyce AJ, Pinto R, Lindstrom E, Holmén-Larsson J, Holtta M, Blennow K, Morris HR, Skillbäck T, Warner TT, Lees AJ, Pike I, Ward M, Zetterberg H, Gobom J. </div> <div> <span class="u-darkerText">Publisher:</span> Parkinsonism Relat Disord. 2017 Apr;37:65-71. doi: 10.1016/j.parkreldis.2017.01.016. Epub 2017 Jan 31. PMID: 28214264. </div> <div> <span class="u-darkerText">Date:</span> April 2017 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/28214264/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag=""> <h2 class="u-redlineLeftSm">Interrelationship between the levels of C9orf72 and amyloid-尾 protein precursor and amyloid-尾 in human cells and brain samples</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> S. Leskelä et al </div> <div> <span class="u-darkerText">Publisher:</span> Journal of Alzheimer's disease 62(1):269-278 DOI: 10.3233/JAD-170362 </div> <div> <span class="u-darkerText">Date:</span> February 2018 </div> </div> <a class="Button u-margBottom4" href="https://content.iospress.com/articles/journal-of-alzheimers-disease/jad170362" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag=""> <h2 class="u-redlineLeftSm">The proteome of neurofilament-containing protein aggregates in blood</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> R. Adiutori et al. </div> <div> <span class="u-darkerText">Publisher:</span> Biochemistry and Biophysics Reports 14, Pages 168-177 </div> <div> <span class="u-darkerText">Date:</span> May 2018 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/29872749/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag=""> <h2 class="u-redlineLeftSm">Tissue-enhanced plasma proteomic analysis for disease stratification in amyotrophic lateral sclerosis</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> I. Zubiri et al. </div> <div> <span class="u-darkerText">Publisher:</span> Molecular Neurodegeneration 13(1) DOI: 10.1186/s13024-018-0292-2 </div> <div> <span class="u-darkerText">Date:</span> November 2018 </div> </div> <a class="Button u-margBottom4" href="https://pubmed.ncbi.nlm.nih.gov/30404656/" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="7" data-tag=""> <h2 class="u-redlineLeftSm">A multiomic approach to characterize the temporal sequence in Alzheimer's disease-related pathology</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> </div> <div> <span class="u-darkerText">Publisher:</span> Science Direct </div> <div> <span class="u-darkerText">Date:</span> January 2019 </div> </div> <a class="Button u-margBottom4" href="https://doi.org/10.1016/j.nbd.2018.12.009" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="16" data-tag="6"> <h2 class="u-redlineLeftSm">Combined tissue and fluid proteomics with Tandem Mass Tags to identify low abundant protein biomarkers of disease in peripheral body fluid: An Alzheimer's disease case study</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/tmtcalibrator-workflow">TMTcalibrator</a> tissue-enhanced fluid proteomics </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Russell CL, Heslegrave A, Mitra V, Zetterberg H, Pocock JM, Ward MA, Pike I </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> November 2016 </div> </div> <a class="Button u-margBottom4" href="https://www.ncbi.nlm.nih.gov/pubmed/27813239" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="16" data-tag="6"> <h2 class="u-redlineLeftSm">Comprehensive quantitative profiling of Tau and phosphorylated Tau peptides in cerebrospinal fluid by Mass Spectrometry provides new biomarker candidate</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/tmtcalibrator-workflow">TMTcalibrator</a> tissue-enhanced fluid proteomics </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Claire L. Russell, Vikram Mitra, Karl Hansson, Kaj Blennow, Johan Gobom, Henrik Zetterber, Mikko Hiltunen, Malcolm Ward and Ian Pike </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> November 2016 </div> </div> <a class="Button u-margBottom4" href="https://www.ncbi.nlm.nih.gov/pubmed/27636850" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="18" data-tag=""> <h2 class="u-redlineLeftSm">Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Thompson A, Schäfer J, Kuhn K, Kienle S, Schwarz J, Schmidt G, Neumann T, Johnstone R, Mohammed AK, Hamon C. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> April 2003 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/12713048" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="18" data-tag=""> <h2 class="u-redlineLeftSm">Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Hahne H, Neubert P, Kuhn K, Etienne C, Bomgarden R, Rogers JC, Kuster B. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2012 Apr </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/22455665" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="18" data-tag=""> <h2 class="u-redlineLeftSm"> Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> McAlister GC, Huttlin EL, Haas W, Ting L, Jedrychowski MP, Rogers JC, Kuhn K, Pike I, Grothe RA, Blethrow JD, Gygi SP. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2012 Sep </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/22880955" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="18" data-tag=""> <h2 class="u-redlineLeftSm">Low-pH solid-phase amino labeling of complex peptide digests with TMTs Improves peptide identification rates for multiplexed global phosphopeptide analysis.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Böhm G, Prefot P, Jung S, Selzer S, Mitra V, Britton D, Kuhn K, Pike I, Thompson AH. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> June 2015 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/25939058" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="18" data-tag=""> <h2 class="u-redlineLeftSm">Quantitation of protein post-translational modifications using isobaric tandem mass tags.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Liang HC, Lahert E, Pike I, Ward M. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2015 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/25697195" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="7" data-tag="7"> <h2 class="u-redlineLeftSm">Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: Cancer</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Britton D, Zen Y, Quaglia A, Selzer S, Mitra V, Löβner C, Jung S, Böhm G, Schmid P, Prefot P, Hoehle C, Koncarevic S, Gee J, Nicholson R, Ward M, Castellano L, Stebbing J, Zucht HD, Sarker D, Heaton N, Pike I. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2014 March </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/24670416" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="16" data-tag="6"> <h2 class="u-redlineLeftSm">Isobaric tagging-based selection and quantitation of cerebrospinal fluid tryptic peptides with reporter calibration curves.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/tmtcalibrator-workflow">TMTcalibrator</a> tissue-enhanced fluid proteomics </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Dayon L, Turck N, Kienle S, Schulz-Knappe P, Hochstrasser DF, Scherl A, Sanchez JC. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2010 Feb </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/20058875" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="7" data-tag=""> <h2 class="u-redlineLeftSm">Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Hanger DP, Byers HL, Wray S, Leung KY, Saxton MJ, Seereeram A, Reynolds CH, Ward MA, Anderton BH. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2017 Aug </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/17562708" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="7" data-tag="6"> <h2 class="u-redlineLeftSm">Tyrosine聽phosphorylation聽of聽tau聽by the聽SRC聽family kinases Lck and Fyn.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Scales TM, Derkinderen P, Leung KY, Byers HL, Ward MA, Price C, Bird IN, Perera T, Kellie S, Williamson R, Anderton BH, Reynolds CH. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2011 Jan </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/21269457" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="7" data-tag="6"> <h2 class="u-redlineLeftSm">Phosphorylation聽of聽tau聽regulates聽its聽axonal transport聽by controlling its binding to kinesin.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Cuchillo-Ibanez I, Seereeram A, Byers HL, Leung KY, Ward MA, Anderton BH, Hanger DP. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2008 Sep </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/18511549" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="7" data-tag="6"> <h2 class="u-redlineLeftSm">The聽neuronal聽adaptor聽protein聽Fe65聽is phosphorylated by mitogen-activated聽protein聽kinase (ERK1/2).</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/sysquant-workflow">SysQuant</a> global phosphoproteomics </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Standen CL, Perkinton MS, Byers HL, Kesavapany S, Lau KF, Ward M, McLoughlin D, Miller CC. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2003 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/14697653" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">p38alpha聽stress-activated聽protein kinase聽phosphorylates聽neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Ackerley S, Grierson AJ, Banner S, Perkinton MS, Brownlees J, Byers HL, Ward M, Thornhill P, Hussain K, Waby JS, Anderton BH, Cooper JD, Dingwall C, Leigh PN, Shaw CE, Miller CC. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2004 Jun </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/15207859" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">ALS2/Alsin聽regulates聽Rac-PAK signaling and neurite outgrowth.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Tudor EL, Perkinton MS, Schmidt A, Ackerley S, Brownlees J, Jacobsen NJ, Byers HL, Ward M, Hall A, Leigh PN, Shaw CE, McLoughlin DM, Miller CC. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2005 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/16049005" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag=""> <h2 class="u-redlineLeftSm">Reversible cysteine-targeted聽oxidation聽of聽proteins聽during聽renal聽oxidative stress.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Eaton P1, Jones ME, McGregor E, Dunn MJ, Leeds N, Byers HL, Leung KY, Ward MA, Pratt JR, Shattock MJ </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2003 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/12874448" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="32" data-tag=""> <h2 class="u-redlineLeftSm">In-depth profiling of the peripheral blood mononuclear cells proteome for clinical blood proteomics</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/tmt-ms2-workflow">TMT-MS2</a> Broadest Coverage Workflow </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Kon膷arevi膰 S, Lößner C, Kuhn K, Prinz T, Pike I, Zucht HD. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2014 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/24724028" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag=""> <h2 class="u-redlineLeftSm">Protein expression profiles of chemo-resistant mixed phenotype liver tumors using laser microdissection and LC-MS/MS proteomics</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Zen Y, Britton D, Mitra V, Brand A, Jung S, Löβner C, Ward M, Pike I, Heaton N, Quaglia A  </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2013 </div> </div> <a class="Button u-margBottom4" href="http://www.sciencedirect.com/science/article/pii/S221296851300007X" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="7"> <h2 class="u-redlineLeftSm">A global proteomic study identifies distinct pathological features of IgG4-related and primary sclerosing cholangitis.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: Cancer</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Zen Y, Britton D, Mitra V, Pike I, Heaton N, Quaglia A. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2015 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/26308372" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="7"> <h2 class="u-redlineLeftSm">Tubulin 尾-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: Cancer</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Zen Y, Britton D, Mitra V, Pike I, Sarker D, Itoh T, Heaton N, Quaglia A. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2014 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/25039376" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="7"> <h2 class="u-redlineLeftSm">Comparison of the nuclear proteomes of mammary epithelial cells at different stages of functional differentiation.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: Cancer</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Desrivières S, Kuhn K, Müller J, Gläser M, Laria NC, Korder J, Sonnentag M, Neumann T, Schwarz J, Schäfer J, Hamon C, Groner B, Prinz T. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2007 June </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/17514683" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">Proteomics聽for聽brain disorders-the聽promise聽for聽biomarkers.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Ward M, Güntert A, Campbell J, Pike I. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2009 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/19906262" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">Post-translational modifications in Alzheimer's disease and the potential for new biomarkers.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Russell CL, Koncarevic S, Ward MA. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2014 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/24662105" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">Comparison of a protein-level and peptide-level labeling strategy for quantitative proteomics of synaptosomes using isobaric tags.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Engmann O, Campbell J, Ward M, Giese KP, Thompson AJ. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2010 May </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/20218731" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="18" data-tag=""> <h2 class="u-redlineLeftSm">Identification of聽proteins聽of Neisseria meningitidis induced under iron-limiting conditions using the isobaric tandem mass tag (TMT) labeling approach.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/about/tandem-mass-tags">Tandem Mass Tag</a> Protein and Peptide Labeling </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> van Ulsen P, Kuhn K, Prinz T, Legner H, Schmid P, Baumann C, Tommassen J. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2009 Apr </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/19288525" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag=""> <h2 class="u-redlineLeftSm">Detection, quantitation, purification, and identification of聽cardiac聽proteins聽S-thiolated聽during聽ischemia聽and reperfusion.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Eaton P, Byers HL, Leeds N, Ward MA, Shattock MJ. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2002 Mar </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/11777920" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">beta-Actin聽regulates聽platelet聽nitric oxide synthase聽3聽activity through interaction with heat shock protein 90.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Ji Y1, Ferracci G, Warley A, Ward M, Leung KY, Samsuddin S, Lévêque C, Queen L, Reebye V, Pal P, Gkaliagkousi E, Seager M, Ferro A. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2007 May </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/17502619" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag="6"> <h2 class="u-redlineLeftSm">An integrated workflow for聽multiplex聽CSF聽proteomics聽and聽peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Hölttä M, Minthon L, Hansson O, Holmén-Larsson J, Pike I, Ward M, Kuhn K, Rüetschi U, Zetterberg H, Blennow K, Gobom J. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2015 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/25490617" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag="6"> <h2 class="u-redlineLeftSm">Relative quantification of proteins in human cerebrospinal fluids by MS/MS using聽6-plex聽isobaric聽tags.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Dayon L, Hainard A, Licker V, Turck N, Kuhn K, Hochstrasser DF, Burkhard PR, Sanchez JC. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2008 </div> </div> <a class="Button u-margBottom4" href=" http://www.ncbi.nlm.nih.gov/pubmed/18312001" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag="6"> <h2 class="u-redlineLeftSm">Proteome-based plasma biomarkers for Alzheimer's disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper C, Rijsdijk F, Tabrizi SJ, Banner S, Shaw CE, Foy C, Poppe M, Archer N, Hamilton G, Powell J, Brown RG, Sham P, Ward M, Lovestone S. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2006 Nov </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/17071923" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag="6"> <h2 class="u-redlineLeftSm">Plasma proteins predict conversion to dementia from prodromal disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Hye A, Riddoch-Contreras J, Baird AL, Ashton NJ, Bazenet C, Leung R, Westman E, Simmons A, Dobson R, Sattlecker M, Lupton M, Lunnon K, Keohane A, Ward M, Pike I, Zucht HD, Pepin D, Zheng W, Tunnicliffe A, Richardson J, Gauthier S, Soininen H, K艂oszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2014 Nov </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/25012867" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag="6"> <h2 class="u-redlineLeftSm">AddNeuroMed-the European collaboration for the discovery of聽novel聽biomarkers for Alzheimer's disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Lovestone S1, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M; AddNeuroMed Consortium. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2009 Oct </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/19906259" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag="6"> <h2 class="u-redlineLeftSm">Plasma based markers of [11C] PiB-PET brain amyloid burden.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Kiddle SJ, Thambisetty M, Simmons A, Riddoch-Contreras J, Hye A, Westman E, Pike I, Ward M, Johnston C, Lupton MK, Lunnon K, Soininen H, Kloszewska I,Tsolaki M, Vellas B, Mecocci P, Lovestone S, Newhouse S, Dobson R; Alzheimers Disease Neuroimaging Initiative </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2012 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/23028511" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19" data-tag="6"> <h2 class="u-redlineLeftSm">Plasma聽gelsolin聽is decreased and correlates with rate of decline in聽Alzheimer's聽disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Güntert A, Campbell J, Saleem M, O'Brien DP, Thompson AJ, Byers HL, Ward MA, Lovestone S. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2012 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/20571216" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="19,33" data-tag="6"> <h2 class="u-redlineLeftSm">Glycosylation of Human聽Plasma聽Clusterin Yields a Novel Candidate Biomarker of聽Alzheimer's聽Disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/biomarker-discovery">Biomarker Discovery</a></span>, <span class="u-textNoWrap"><a href="/services/srm">SRM </a> Assay Development </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Liang HC, Russell C, Mitra V, Chung R, Hye A, Bazenet C, Lovestone S, Pike I, Ward M. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2015 / 2016 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/26828705" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">Association of聽plasma聽clusterin concentration with severity, pathology, and progression in聽Alzheimer disease.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Thambisetty M1, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Güntert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lynham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C, Leung R, Foy C, O'Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DG, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF,Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2010 </div> </div> <a class="Button u-margBottom4" href=" http://www.ncbi.nlm.nih.gov/pubmed/20603455" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag="6"> <h2 class="u-redlineLeftSm">Proteomic聽profiling聽of聽plasma聽in聽Huntington's disease聽reveals neuroinflammatory activation and biomarker candidates.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Dalrymple A, Wild EJ, Joubert R, Sathasivam K, Björkqvist M, Petersén A, Jackson GS, Isaacs JD, Kristiansen M, Bates GP, Leavitt BR, Keir G, Ward M, Tabrizi SJ. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2007 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/17552550" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="33" data-tag=""> <h2 class="u-redlineLeftSm">Evaluation of absolute peptide quantitation strategies using selected reaction monitoring.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/srm">SRM </a> Assay Development </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Campbell J, Rezai T, Prakash A, Krastins B, Dayon L, Ward M, Robinson S, Lopez M. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2011 Mar </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/21365756" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="33" data-tag="6"> <h2 class="u-redlineLeftSm">Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/srm">SRM </a> Assay Development </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2013 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/22797329" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="33" data-tag="6"> <h2 class="u-redlineLeftSm">Stable mutated tau441 transfected SH-SY5Y cells as screening tool for Alzheimer's disease drug candidates.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/srm">SRM </a> Assay Development </span> </div> <div class="Grid-cell u-size1of3 u-md-sizeFull u-textRight u-md-textLeft u-md-margTop1">Disease Area: CNS</div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Löffler T, Flunkert S, Taub N, Schofield EL, Ward MA, Windisch M, Hutter-Paier B. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2012 May </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/22351109 " target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="33" data-tag=""> <h2 class="u-redlineLeftSm">Increased platelet expression of glycoprotein IIIa following aspirin treatment in aspirin-resistant but not aspirin-sensitive subjects.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto">Product: </div> <div class="Grid-cell u-md-sizeFull"> <span class="u-textNoWrap"><a href="/services/srm">SRM </a> Assay Development </span> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Floyd CN, Goodman T, Becker S, Chen N, Mustafa A, Schofield E, Campbell J, Ward M, Sharma P, Ferro A. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2014 Aug </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/25099258" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> <div class="ContentLine u-margBottom5 js-filterItem" data-category="" data-tag=""> <h2 class="u-redlineLeftSm">Candidate verification of iron-regulated Neisseria meningitidis聽proteins聽using isotopic versions of tandem mass tags (TMT) and single reaction monitoring.</h2> <div class="Grid Grid--fit u-darkerText u-margBottom2"> <div class="Grid-cell u-sizeAuto"></div> <div class="Grid-cell u-md-sizeFull"> </div> </div> <div class="ShadeContent u-margBottom2 u-padRight5"> <div> <span class="u-darkerText">Authors:</span> Byers HL, Campbell J, van Ulsen P, Tommassen J, Ward MA, Schulz-Knappe P, Prinz T, Kuhn K. </div> <div> <span class="u-darkerText">Publisher:</span> PubMed </div> <div> <span class="u-darkerText">Date:</span> 2009 </div> </div> <a class="Button u-margBottom4" href="http://www.ncbi.nlm.nih.gov/pubmed/19778646" target="_blank"><svg class="Icon" aria-hidden="true" focusable="false"><use xlink:href="#icon-open-book"/></svg> <span class="u-alignMiddle">view publication</span></a> </div> </div> </div> </div> </div> <div class="DisplayBanner DisplayBanner--blueGradient u-colorWhite"> <div class="DisplayBanner-overlay" style="background-image: url('https://files.aptuitivcdn.com/JxEdylMPMz-1515/theme/custom/images/hero-overlay.1654711795.png')"></div> <div class="Container"> 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