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Protein Degrader
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href="/contact">contact us</a> </span> <span class="Header-showOnSticky u-padLeft2"> <a class="Button u-lg-hide" href="/contact">contact us</a> </span> </div> </div> </div> </div> </header> <div class="TextHeader"> <div class="Container"> <div class="TextHeader-content"> <h1 class="TextHeader-title u-redlineLeft">Protein Degrader/PROTAC Assays</h1> </div> </div> </div> <main> <div class="Container"> <div class="Content u-cf"> <table class="Table--themed" style="border-collapse: collapse; width: 99.9211%;" border="1"> <thead> <tr> <th style="width: 32.8069%;" scope="col">Application</th> <th style="width: 32.8069%;" scope="col">Service</th> <th style="width: 32.8076%;" scope="col">Description</th> </tr> </thead> <tbody> <tr> <td style="width: 32.8069%;">Protein Degrader/PROTAC Assays</td> <td style="width: 32.8069%;"> <ul> <li><a href="/services/tmt-ms2-workflow">LC-MS2 Proteomics</a></li> <li><a href="/services/sysquant-workflow">SysQuant Ubiquitin </a></li> <li><a href="/services/speciality-proteomics/peptidomics">Peptidomics</a></li> </ul> </td> <td style="width: 32.8076%;"> <ul> <li>Determine total proteome/protein before Degradation</li> <li>Ubiquitinylated intermediate(s)</li> <li>Quantify resulting degraded protein</li> <li>Confirm released peptides during degradation</li> <li>Evaluate effect of the chosen Degrader on downstream signalling</li> <li>Degrader off target effects on whole proteome</li> </ul> </td> </tr> </tbody> </table> <h2>Advantages</h2> <ul> <li>Detection and quantification of 10,000+ proteins in 10 to 100s of cell lysate samples</li> <li>Can determine all or part of <br> <ul> <li>the degrader efficiency in respect of the presence of the degraded protein after reaction, </li> <li>the presence of degraded peptides arising from the degradation</li> <li>the ubiquitylation intermediate</li> <li>the effect of protein loss on downstream signalling pathways</li> <li>the specificity of the degrader to a single selected protein or cross reactivity of other proteins in the sample proteome</li> <li>monitor off target / adverse effects</li> </ul> </li> <li>Includes full computational proteomic analysis and bioinformatics covering extensive data interpretation, including pathway analysis and biological relevance</li> </ul> <p>Targeted protein degradation through the use of molecular glues and PROTAC’s (proteolysis targeting chimera) is a rapidly evolving field using small molecules to promote selective tagging of target proteins and directing them for proteosomal or lysosomal degradation. Whilst the approach can be highly selective, it is important to monitor the level of protein degradation and look for non-specific protein targeting.</p> <p>We offer analytical services to support targeted protein degradation drugs at multiple levels (Figure 1). </p> <p>Peptidomics - identify & measure proteosomal/lysosomal peptide fragments <br>Proteomics - confirm loss of target protein, assess evidence of cross-reactivity, monitor wider changes in cell signalling and biological processes<br>Enrichment Proteomics - monitor levels of pro-degradation tagging (Ubiquitin, LC3B etc)</p> <p>Any of these workflows can be run as single projects, e.g. to only monitor changes in the total proteome before and after Degrader action.</p> <div class="Grid Grid--withGutter u-margTop3 u-margBottom5"> <div class="Grid-cell u-size2of5 u-md-sizeFull u-gutters4 u-textCenter"> <div class="PopImage"><img src="https://files.aptuitivcdn.com/JxEdylMPMz-1515/images/combination-of-technologies-2.png" height="281" width="500" class="PopImage-image u-sizeFull u-lg-sizeAuto u-sm-sizeFull" alt=""></div> </div> <div class="Grid-cell u-size3of5 u-md-sizeFull u-md-gutters4"> <p><strong>Figure 1</strong> - Three-level analysis of targeted protein degradation using sequential sample preparation and mass spectrometry with TMT and TMTpro reagents.</p> </div> </div> <table class="Table--themed" style="border-collapse: collapse; width: 99.8727%;" border="1"> <tbody> <tr> <td style="width: 49.1396%;">What’s included</td> <td style="width: 49.1396%;"> <ul> <li>Incoming sample QC to check sufficient protein in samples for a satisfactory analysis</li> <li>Protein isolation, peptide cleavage and TMT labelling</li> <li>Mass spectrometry-based peptide and protein ID</li> <li>Computational proteomics and full bioinformatics analysis</li> <li>Comprehensive report summarising the proteins, peptides and if applicable the peptide-PTM’s. Data interpretation, pathway analysis and biological relevance</li> <li>An Excel based QuantSheet detailing qualitative and quantitative protein identification data.</li> <li>Provision of all raw data if required</li> </ul> </td> </tr> <tr> <td style="width: 49.1396%;">Material required</td> <td style="width: 49.1396%;"> <ul> <li>This is sample and assay specific and will be detailed in the agreed Statement of Work - please <a href="/contact">contact us</a> to discuss your specific needs so we can start the Statement of Work preparation</li> </ul> </td> </tr> <tr> <td style="width: 49.1396%;">Typical turnaround time</td> <td style="width: 49.1396%;"> <ul> <li>Generally 6 to 8 weeks from receipt of up to 36 samples to submission of the comprehensive analytical report and associated data.</li> </ul> </td> </tr> </tbody> </table> </div> </div> </main> <footer class="Footer"> <div class="Footer-upper"> <div class="Container"> <div class="Grid Grid--fit Grid--alignMiddle"> <div class="Grid-cell u-sizeAuto u-lg-hide"> <a href="/" title="Back to home page"> <img class="Footer-logo" src="https://files.aptuitivcdn.com/JxEdylMPMz-1515/theme/custom/images/logo-white.1654711795.svg" alt="Proteome Sciences"> </a> </div> <div class="Grid-cell u-lg-sizeFull u-lg-textCenter"> <ul class="FooterNav"> <li class="FooterNav-item is-first"> <a href="/about" class="is-first FooterNav-link">About Us</a> </li> <li class="FooterNav-item is-current"> <a href="/services" class="is-current FooterNav-link">Proteomic Services</a> </li> <li class="FooterNav-item"> <a href="/news" class="FooterNav-link">News</a> </li> <li class="FooterNav-item"> <a href="/investors" class="FooterNav-link">Investors</a> </li> <li class="FooterNav-item"> <a href="/contact" class="FooterNav-link">Contact</a> </li> <li class="FooterNav-item is-last"> <a href="/privacy-notice" class="is-last FooterNav-link">Privacy Notice</a> </li> </ul> </div> <div class="Grid-cell u-sizeAuto u-lg-size1of2 u-textRight u-lg-textCenter u-sm-sizeFull u-sm-margBottom4"> <img src="https://files.aptuitivcdn.com/JxEdylMPMz-1515/images/ISO-9001-2.2015.jpg" height="125" width="150" alt="DQS Quality Management" class="Footer-badge"> <a href="https://twitter.com/ProteomeScience" title="Follow us on Twitter" class="Footer-iconLink" target="_blank" rel="noopenner noreferrer"> <svg class="Footer-icon Icon" role="img" alt="Twitter" aria-labelledby="iconTitle-sSQqXr" focusable="false"><title id="iconTitle-sSQqXr">Twitter</title><use xlink:href="#icon-twitter" /></svg></a> <a href="https://www.linkedin.com/company/proteome-sciences-plc" title="Follow us on LinkedIn" class="Footer-iconLink" target="_blank" rel="noopenner noreferrer"> <svg class="Footer-icon Icon" role="img" alt="LinkedIn" aria-labelledby="iconTitle-gn8DUg" focusable="false"><title id="iconTitle-gn8DUg">LinkedIn</title><use xlink:href="#icon-linkedin" /></svg></a> </div> </div> </div> </div> <div class="Container u-spaced1 u-gutters1"> <div class="Grid Grid--fit Grid--alignMiddle"> <div class="Grid-cell u-sizeAuto u-md-size1of2 u-md-textCenter u-sm-sizeFull u-sm-margBottom1 u-darkerText">Copyright © Proteome Sciences 2024</div> <div class="Grid-cell u-md-size1of2 u-md-textCenter u-sm-sizeFull u-darkerText"></div> <div class="Grid-cell u-sizeAuto u-md-sizeFull u-md-textCenter"> <div class="Footer-credit u-inlineBlock"> <a href="https://www.aptuitiv.com" target="_blank" class="Footer-link Footer-creditLink">Site Design By Aptuitiv</a>-<a href="https://www.branchcms.com" target="_blank" class="Footer-link Footer-creditLink">Powered by BranchCMS</a> </div> </div> </div> </div> </footer> <script> tarteaucitron.services.recaptchav3 = { "key": "recaptchav3", "type": "analytic", "name": "reCAPTCHA", "needConsent": true, "cookies": ['_GRECAPTCHA', 'AEC'], "js": function () { "use strict"; 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