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id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Glucagon-like peptide-1 receptor</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in 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href="https://fa.wikipedia.org/wiki/%DA%AF%DB%8C%D8%B1%D9%86%D8%AF%D9%87_%D9%BE%D9%BE%D8%AA%DB%8C%D8%AF_%D8%B4%D8%A8%D9%87%E2%80%8C%DA%AF%D9%84%D9%88%DA%A9%D8%A7%DA%AF%D9%88%D9%86_%DB%B1" title="گیرنده پپتید شبه‌گلوکاگون ۱ – Persian" lang="fa" hreflang="fa" data-title="گیرنده پپتید شبه‌گلوکاگون ۱" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/R%C3%A9cepteur_du_glucagon-like_peptide-1" title="Récepteur du glucagon-like peptide-1 – French" lang="fr" hreflang="fr" data-title="Récepteur du glucagon-like peptide-1" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Receptor_glukagonu_sli%C4%8Dnog_peptida_1" title="Receptor glukagonu sličnog peptida 1 – Serbian" lang="sr" hreflang="sr" data-title="Receptor glukagonu sličnog peptida 1" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Receptor_glukagonu_sli%C4%8Dnog_peptida_1" title="Receptor glukagonu sličnog peptida 1 – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Receptor glukagonu sličnog peptida 1" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/GLP1R" title="GLP1R – Tatar" lang="tt" hreflang="tt" data-title="GLP1R" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/GLP1R" title="GLP1R – Ukrainian" lang="uk" hreflang="uk" data-title="GLP1R" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q14909910#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected 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</div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to 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style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:GLP-1R_apo.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/GLP-1R_apo.png/250px-GLP-1R_apo.png" decoding="async" width="250" height="271" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/87/GLP-1R_apo.png/375px-GLP-1R_apo.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/87/GLP-1R_apo.png/500px-GLP-1R_apo.png 2x" data-file-width="1891" data-file-height="2047" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Available structures</th></tr><tr><th rowspan="2" style="background-color:#c3fdb8;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:#eee">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=O35659%20or%20P43220">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:O35659,P43220">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="background-color:#ddd;text-align:center"><th colspan="2">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:#eee"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3C59">3C59</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3C5T">3C5T</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3IOL">3IOL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4ZGM">4ZGM</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/4324">GLP1R</a></span>, glucagon-like peptide 1 receptor, GLP-1, GLP-1-R, GLP-1R, glucagon like peptide 1 receptor</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/138032">138032</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:99571">99571</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=1558">1558</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=GLP1R">GLP1R</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000112164">GLP1R - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_6.svg" class="mw-file-description" title="Chromosome 6 (human)"><img alt="Chromosome 6 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/300px-Ideogram_human_chromosome_6.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/450px-Ideogram_human_chromosome_6.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_human_chromosome_6.svg/600px-Ideogram_human_chromosome_6.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_6_(human)" class="mw-redirect" title="Chromosome 6 (human)">Chromosome 6 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_6_ideogram.svg" class="mw-file-description" title="Chromosome 6 (human)"><img alt="Chromosome 6 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/300px-Human_chromosome_6_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/450px-Human_chromosome_6_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9b/Human_chromosome_6_ideogram.svg/600px-Human_chromosome_6_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 61.879825594363px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for GLP1R"><img alt="Genomic location for GLP1R" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 67.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for GLP1R"><img alt="Genomic location for GLP1R" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">6p21.2</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">39,048,781 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">39,091,303 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (mouse)"><img alt="Chromosome 17 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/260px-Ideogram_house_mouse_chromosome_17.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/390px-Ideogram_house_mouse_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/13/Ideogram_house_mouse_chromosome_17.svg/520px-Ideogram_house_mouse_chromosome_17.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 17 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (mouse)"><img alt="Chromosome 17 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/Ideogram_of_house_mouse_chromosome_17.svg/300px-Ideogram_of_house_mouse_chromosome_17.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/47/Ideogram_of_house_mouse_chromosome_17.svg/450px-Ideogram_of_house_mouse_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/47/Ideogram_of_house_mouse_chromosome_17.svg/600px-Ideogram_of_house_mouse_chromosome_17.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 91.027547824062px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for GLP1R"><img alt="Genomic location for GLP1R" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 97px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for GLP1R"><img alt="Genomic location for GLP1R" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">17 A3.3|17 15.8 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">31,120,791 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">31,159,765 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000112164">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">islet of Langerhans</li><br /><li style="line-height: 137%;">sperm</li><br /><li style="line-height: 137%;">vena cava</li><br /><li style="line-height: 137%;">body of pancreas</li><br /><li style="line-height: 137%;">oocyte</li><br /><li style="line-height: 137%;">periodontal fiber</li><br /><li style="line-height: 137%;">secondary oocyte</li><br /><li style="line-height: 137%;">cardia</li><br /><li style="line-height: 137%;">medulla oblongata</li><br /><li style="line-height: 137%;">pons</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000024027">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">islet of Langerhans</li><br /><li style="line-height: 137%;">supraoptic nucleus</li><br /><li style="line-height: 137%;">left lung lobe</li><br /><li style="line-height: 137%;">right lung lobe</li><br /><li style="line-height: 137%;">lumbar subsegment of spinal cord</li><br /><li style="line-height: 137%;">pontine nuclei</li><br /><li style="line-height: 137%;">lateral septal nucleus</li><br /><li style="line-height: 137%;">duodenum</li><br /><li style="line-height: 137%;">epithelium of stomach</li><br /><li style="line-height: 137%;">ganglion of vagus nerve</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000112164">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_GLP1R_208390_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/92/PBB_GE_GLP1R_208390_s_at_fs.png/250px-PBB_GE_GLP1R_208390_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/92/PBB_GE_GLP1R_208390_s_at_fs.png/375px-PBB_GE_GLP1R_208390_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/92/PBB_GE_GLP1R_208390_s_at_fs.png/500px-PBB_GE_GLP1R_208390_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_GLP1R_208391_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_GE_GLP1R_208391_s_at_fs.png/250px-PBB_GE_GLP1R_208391_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_GE_GLP1R_208391_s_at_fs.png/375px-PBB_GE_GLP1R_208391_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/PBB_GE_GLP1R_208391_s_at_fs.png/500px-PBB_GE_GLP1R_208391_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_GLP1R_208401_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/PBB_GE_GLP1R_208401_s_at_fs.png/250px-PBB_GE_GLP1R_208401_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/PBB_GE_GLP1R_208401_s_at_fs.png/375px-PBB_GE_GLP1R_208401_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/PBB_GE_GLP1R_208401_s_at_fs.png/500px-PBB_GE_GLP1R_208401_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/2740/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008528">G protein-coupled peptide receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004930">G protein-coupled receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/">signal transducer activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004967">glucagon receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004888">transmembrane signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044508">glucagon-like peptide 1 receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017046">peptide hormone binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005622">intracellular anatomical structure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008016">regulation of heart contraction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050796">regulation of insulin secretion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007204">positive regulation of cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071377">cellular response to glucagon stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007190">activation of adenylate cyclase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007166">cell surface receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045777">positive regulation of blood pressure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007611">learning or memory</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019933">cAMP-mediated signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007189">adenylate cyclase-activating G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007186">G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1990911">response to psychosocial stress</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=2740&rn=1">2740</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=14652&rn=1">14652</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000112164;db=core">ENSG00000112164</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000024027;db=core">ENSMUSG00000024027</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P43220">P43220</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O35659">O35659</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_002062">NM_002062</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_021332">NM_021332</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_002053">NP_002053</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_067307">NP_067307</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr6:39048781-39091303">Chr 6: 39.05 – 39.09 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr17:31120791-31159765">Chr 17: 31.12 – 31.16 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14909910" class="extiw" title="d:Q14909910">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14909916" class="extiw" title="d:Q14909916">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p>The <b>glucagon-like peptide-1 receptor</b> (<b>GLP1R</b>) is a <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptor</a> (GPCR) found on <a href="/wiki/Beta_cell" title="Beta cell">beta cells</a> of the pancreas and on <a href="/wiki/Neurons" class="mw-redirect" title="Neurons">neurons</a> of the brain. It is involved in the control of <a href="/wiki/Blood_sugar_level" title="Blood sugar level">blood sugar level</a> by enhancing insulin secretion. In humans it is synthesised by the <a href="/wiki/Gene" title="Gene">gene</a> <i>GLP1R</i>, which is present on <a href="/wiki/Chromosome_6" title="Chromosome 6">chromosome 6</a>.<sup id="cite_ref-pmid1326760_5-0" class="reference"><a href="#cite_note-pmid1326760-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8404634_6-0" class="reference"><a href="#cite_note-pmid8404634-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> It is a member of the <a href="/wiki/Glucagon_receptor_family" title="Glucagon receptor family">glucagon receptor family</a> of GPCRs.<sup id="cite_ref-pmid12529935_7-0" class="reference"><a href="#cite_note-pmid12529935-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> GLP1R is composed of two domains, one extracellular (ECD) that binds the C-terminal helix of GLP-1,<sup id="cite_ref-pmid27059958_8-0" class="reference"><a href="#cite_note-pmid27059958-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> and one transmembrane (TMD) domain<sup id="cite_ref-doi10.1038/nature22378_9-0" class="reference"><a href="#cite_note-doi10.1038/nature22378-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> that binds the N-terminal region of GLP-1.<sup id="cite_ref-pmid26700562_10-0" class="reference"><a href="#cite_note-pmid26700562-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid27315480_11-0" class="reference"><a href="#cite_note-pmid27315480-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid19861722_12-0" class="reference"><a href="#cite_note-pmid19861722-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> In the TMD domain there is a fulcrum of polar residues that regulates the biased signaling of the receptor <sup id="cite_ref-pmid26700562_10-1" class="reference"><a href="#cite_note-pmid26700562-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> while the transmembrane helical boundaries<sup id="cite_ref-pmid27569426_13-0" class="reference"><a href="#cite_note-pmid27569426-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> and extracellular surface are a trigger for biased agonism.<sup id="cite_ref-pmid27315480_11-1" class="reference"><a href="#cite_note-pmid27315480-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Ligands">Ligands</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=1" title="Edit section: Ligands"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>GLP1R binds <a href="/wiki/Glucagon-like_peptide-1" title="Glucagon-like peptide-1">glucagon-like peptide-1</a> (GLP1) and <a href="/wiki/Glucagon" title="Glucagon">glucagon</a> as its natural endogenous agonists.<sup id="cite_ref-IUPHAR_2015_GLP-1_14-0" class="reference"><a href="#cite_note-IUPHAR_2015_GLP-1-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Receptor_agonist" class="mw-redirect" title="Receptor agonist">Agonists</a>: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Glucagon-like_peptide-1" title="Glucagon-like peptide-1">GLP-1</a> – endogenous in humans<sup id="cite_ref-IUPHAR_2015_GLP-1_14-1" class="reference"><a href="#cite_note-IUPHAR_2015_GLP-1-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Glucagon" title="Glucagon">glucagon</a> – endogenous in humans<sup id="cite_ref-IUPHAR_2015_GLP-1_14-2" class="reference"><a href="#cite_note-IUPHAR_2015_GLP-1-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Oxyntomodulin" title="Oxyntomodulin">oxyntomodulin</a></li> <li><a href="/w/index.php?title=Exendin-4&action=edit&redlink=1" class="new" title="Exendin-4 (page does not exist)">exendin-4</a>,<sup id="cite_ref-IUPHAR_2015_GLP-1_14-3" class="reference"><a href="#cite_note-IUPHAR_2015_GLP-1-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid28283573_15-0" class="reference"><a href="#cite_note-pmid28283573-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Exenatide" title="Exenatide">exenatide</a></li> <li><a href="/wiki/Lixisenatide" title="Lixisenatide">lixisenatide</a><sup id="cite_ref-IUPHAR_2015_GLP-1_14-4" class="reference"><a href="#cite_note-IUPHAR_2015_GLP-1-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li></ul> <ul><li><a href="/wiki/Albiglutide" title="Albiglutide">albiglutide</a></li> <li><a href="/w/index.php?title=Beinaglutide&action=edit&redlink=1" class="new" title="Beinaglutide (page does not exist)">beinaglutide</a></li> <li><a href="/wiki/Dulaglutide" title="Dulaglutide">dulaglutide</a></li> <li><a href="/wiki/Efpeglenatide" title="Efpeglenatide">efpeglenatide</a></li> <li><a href="/w/index.php?title=Langlenatide&action=edit&redlink=1" class="new" title="Langlenatide (page does not exist)">langlenatide</a></li> <li><a href="/wiki/Liraglutide" title="Liraglutide">liraglutide</a><sup id="cite_ref-IUPHAR_2015_GLP-1_14-5" class="reference"><a href="#cite_note-IUPHAR_2015_GLP-1-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=PEG-_Loxenatide&action=edit&redlink=1" class="new" title="PEG- Loxenatide (page does not exist)">PEG- Loxenatide</a></li> <li><a href="/wiki/Semaglutide" title="Semaglutide">semaglutide</a></li> <li><a href="/wiki/Taspoglutide" title="Taspoglutide">taspoglutide</a></li> <li><a href="/wiki/Ecnoglutide" title="Ecnoglutide">Ecnoglutide</a></li> <li><a href="/w/index.php?title=Utreglutide&action=edit&redlink=1" class="new" title="Utreglutide (page does not exist)">Utreglutide</a></li> <li><a href="/w/index.php?title=Glepaglutide&action=edit&redlink=1" class="new" title="Glepaglutide (page does not exist)">Glepaglutide</a></li> <li><a href="/w/index.php?title=Apraglutide&action=edit&redlink=1" class="new" title="Apraglutide (page does not exist)">Apraglutide</a></li> <li><a href="/w/index.php?title=Maridebart_Cafraglutide&action=edit&redlink=1" class="new" title="Maridebart Cafraglutide (page does not exist)">Maridebart Cafraglutide</a>/<a href="/w/index.php?title=AMG133&action=edit&redlink=1" class="new" title="AMG133 (page does not exist)">AMG133</a></li> <li><a href="/wiki/Tirzepatide" title="Tirzepatide">Tirzepatide</a></li> <li><a href="/w/index.php?title=Pegapamodutide&action=edit&redlink=1" class="new" title="Pegapamodutide (page does not exist)">pegapamodutide</a></li> <li><a href="/wiki/Mazdutide" title="Mazdutide">Mazdutide</a></li> <li><a href="/wiki/Survodutide" title="Survodutide">Survodutide</a></li> <li><a href="/w/index.php?title=Bamadutide&action=edit&redlink=1" class="new" title="Bamadutide (page does not exist)">Bamadutide</a></li> <li><a href="/wiki/Pemvidutide" title="Pemvidutide">Pemvidutide</a></li> <li><a href="/wiki/Cotadutide" title="Cotadutide">Cotadutide</a></li> <li><a href="/wiki/Retatrutide" title="Retatrutide">Retatrutide</a></li> <li><a href="/wiki/Lithium_chloride" title="Lithium chloride">lithium chloride</a></li> <li><a href="/w/index.php?title=Grutalumab&action=edit&redlink=1" class="new" title="Grutalumab (page does not exist)">Grutalumab</a></li> <li><a href="/w/index.php?title=DA1726&action=edit&redlink=1" class="new" title="DA1726 (page does not exist)">DA1726</a></li> <li><a href="/w/index.php?title=GX-G6&action=edit&redlink=1" class="new" title="GX-G6 (page does not exist)">GX-G6</a></li> <li><a href="/w/index.php?title=GZR18&action=edit&redlink=1" class="new" title="GZR18 (page does not exist)">GZR18</a></li> <li><a href="/wiki/HRS9531" title="HRS9531">HRS9531</a></li> <li><a href="/w/index.php?title=BGMO504&action=edit&redlink=1" class="new" title="BGMO504 (page does not exist)">BGMO504</a></li> <li><a href="/w/index.php?title=PB718&action=edit&redlink=1" class="new" title="PB718 (page does not exist)">PB718</a></li> <li><a href="/w/index.php?title=RAY1225&action=edit&redlink=1" class="new" title="RAY1225 (page does not exist)">RAY1225</a></li> <li><a href="/w/index.php?title=VCT220&action=edit&redlink=1" class="new" title="VCT220 (page does not exist)">VCT220</a></li> <li><a href="/wiki/VK2735" title="VK2735">VK2735</a></li> <li><a href="/w/index.php?title=BLX7006&action=edit&redlink=1" class="new" title="BLX7006 (page does not exist)">BLX7006</a></li> <li><a href="/w/index.php?title=Supaglutide&action=edit&redlink=1" class="new" title="Supaglutide (page does not exist)">Supaglutide</a></li> <li><a href="/w/index.php?title=ASC30&action=edit&redlink=1" class="new" title="ASC30 (page does not exist)">ASC30</a></li> <li><a href="/wiki/Danuglipron" title="Danuglipron">Danuglipron</a></li> <li><a href="/wiki/Aleniglipron" title="Aleniglipron">Aleniglipron</a>(<a href="/wiki/GSBR-1290" class="mw-redirect" title="GSBR-1290">GSBR-1290</a>)</li> <li><a href="/wiki/Lotiglipron" title="Lotiglipron">Lotiglipron</a></li> <li><a href="/wiki/Orforglipron" title="Orforglipron">Orforglipron</a></li> <li><a href="/w/index.php?title=CT-996&action=edit&redlink=1" class="new" title="CT-996 (page does not exist)">CT-996</a></li> <li><a href="/wiki/CT-388" title="CT-388">CT-388</a></li></ul> <p><br /> </p> </div> <p><a href="/wiki/Receptor_antagonist" title="Receptor antagonist">Antagonists</a>: </p> <ul><li>[9-39]-GLP-1</li> <li>T-0632<sup id="cite_ref-IU*PHAR_2015_GLP-1_16-0" class="reference"><a href="#cite_note-IU*PHAR_2015_GLP-1-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup></li> <li>GLP1R0017<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup></li></ul> <p><a href="/wiki/Allosteric_modulator" title="Allosteric modulator">Allosteric modulators</a> </p> <ul><li>Positive: <ul><li><a href="/w/index.php?title=BETP&action=edit&redlink=1" class="new" title="BETP (page does not exist)">BETP</a></li></ul></li></ul> <ul><li>Negative: <ul><li><a href="/w/index.php?title=HTL26119&action=edit&redlink=1" class="new" title="HTL26119 (page does not exist)">HTL26119</a><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup></li> <li class="mw-empty-elt"></li> <li class="mw-empty-elt"></li> <li class="mw-empty-elt"></li></ul></li></ul> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=2" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The GLP-1 receptor is a transmembrane protein composed of seven alpha-helical transmembrane domains (TM1-TM7), an extracellular N-terminus, and an intracellular C-terminus. It belongs to the class B family of G protein-coupled receptors, also known as secretin-like receptors. The N-terminus of the receptor is responsible for binding glucagon-like peptide-1 (GLP-1) ligands, while the intracellular C-terminus interacts with intracellular signaling proteins to initiate downstream signaling pathways. </p><p>The extracellular N-terminus contains key regions involved in ligand recognition and binding. It undergoes conformational changes upon ligand binding, leading to activation of intracellular signaling cascades. The intracellular C-terminus interacts with <a href="/wiki/G_proteins" class="mw-redirect" title="G proteins">G proteins</a> and other signaling molecules to initiate cellular responses. </p> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:GLP-1R_complex.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0a/GLP-1R_complex.png/220px-GLP-1R_complex.png" decoding="async" width="220" height="391" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0a/GLP-1R_complex.png/330px-GLP-1R_complex.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0a/GLP-1R_complex.png/440px-GLP-1R_complex.png 2x" data-file-width="2160" data-file-height="3840" /></a><figcaption>Structure of GLP-1R-G protein complex bound to <a href="/wiki/Tirzepatide" title="Tirzepatide">tirzepatide</a>. Based on PDB entry <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/7RGP">7RGP</a>(cryo-EM of human Glucagon-like peptide 1 receptor GLP-1R bound to tirzepatide). Tirzepatide shown in red, GLP-1R shown in green, <a href="/wiki/G_alpha_subunit" title="G alpha subunit">G alpha subunit</a> shown in white, <a href="/wiki/G_beta-gamma_complex" title="G beta-gamma complex">G beta-gamma complex</a> shown in dark gray.</figcaption></figure> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=3" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Glucagon-like_peptide-1" title="Glucagon-like peptide-1">Glucagon-like peptide-1</a> (GLP-1) is a hormone consisting of 30 amino acids. It is released by intestinal <a href="/w/index.php?title=L_cells&action=edit&redlink=1" class="new" title="L cells (page does not exist)">L cells</a> when nutrients are consumed. GLP-1 has multiple effects, including enhancing <a href="/wiki/Insulin" title="Insulin">insulin</a> secretion from pancreatic beta cells in response to <a href="/wiki/Glucose" title="Glucose">glucose</a>, increasing insulin expression, preventing beta-cell apoptosis, promoting the formation of new beta cells, reducing glucagon secretion, slowing down stomach emptying, promoting satiety, and improving glucose disposal in peripheral tissues. Due to these diverse effects, there has been significant interest in developing long-lasting agonists of the GLP-1 receptor (GLP-1R) for the treatment of type 2 diabetes (T2D). </p><p>GLP1R is also expressed in the brain<sup id="cite_ref-pmid26500843_19-0" class="reference"><a href="#cite_note-pmid26500843-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> where it is involved in the control of <a href="/wiki/Appetite" title="Appetite">appetite</a>.<sup id="cite_ref-pmid12451146_20-0" class="reference"><a href="#cite_note-pmid12451146-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> Furthermore, mice that over express GLP1R display improved memory and learning.<sup id="cite_ref-pmid12925848_21-0" class="reference"><a href="#cite_note-pmid12925848-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p><p>Stretch responsive vagal neurons in the stomach and intestines also express GLP1R.<sup id="cite_ref-Williams_2016_22-0" class="reference"><a href="#cite_note-Williams_2016-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> GLP1R neurons particularly and densely innervate stomach muscle and can communicate with additional organ systems changing breathing and heart rate due to activation.<sup id="cite_ref-Williams_2016_22-1" class="reference"><a href="#cite_note-Williams_2016-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mechanism_of_action">Mechanism of action</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=4" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Upon binding to its ligand GLP-1, the GLP-1 receptor activates intracellular signaling pathways that regulate insulin secretion, glucose metabolism, and satiety. In pancreatic beta cells, GLP-1 receptor activation enhances glucose-stimulated insulin secretion. This occurs through the activation of adenylyl cyclase, leading to increased intracellular levels of cyclic AMP (cAMP). The rise in cAMP activates protein kinase A (PKA), which promotes insulin exocytosis and enhances beta cell survival and proliferation. GLP-1 receptor signaling in pancreatic alpha cells reduces glucagon secretion, further contributing to glucose lowering. By inhibiting glucagon release, GLP-1 receptor activation helps to maintain glucose homeostasis. Another important function of the GLP-1 receptor is the regulation of gastric emptying. Activation of the receptor delays the rate at which the stomach empties, leading to increased satiety and reduced food intake. This effect contributes to weight management and appetite control. </p><p>'<b>Appetite regulation and satiety'</b>: GLP-1 receptor signaling influences the central nervous system, particularly regions involved in appetite regulation. Activation of the GLP-1 receptor promotes feelings of satiety, leading to a reduction in food intake and improved weight management. </p><p><b>Gastric emptying'</b>: GLP-1 receptor activation slows down the rate at which the stomach empties its contents into the small intestine. This delay in gastric emptying contributes to the feeling of fullness and aids in controlling postprandial blood glucose levels. </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=5" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1251242444">.mw-parser-output .ambox{border:1px solid #a2a9b1;border-left:10px solid #36c;background-color:#fbfbfb;box-sizing:border-box}.mw-parser-output .ambox+link+.ambox,.mw-parser-output .ambox+link+style+.ambox,.mw-parser-output .ambox+link+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+style+.ambox,.mw-parser-output .ambox+.mw-empty-elt+link+link+.ambox{margin-top:-1px}html body.mediawiki .mw-parser-output .ambox.mbox-small-left{margin:4px 1em 4px 0;overflow:hidden;width:238px;border-collapse:collapse;font-size:88%;line-height:1.25em}.mw-parser-output .ambox-speedy{border-left:10px solid #b32424;background-color:#fee7e6}.mw-parser-output .ambox-delete{border-left:10px solid #b32424}.mw-parser-output .ambox-content{border-left:10px solid #f28500}.mw-parser-output .ambox-style{border-left:10px solid #fc3}.mw-parser-output .ambox-move{border-left:10px solid #9932cc}.mw-parser-output .ambox-protection{border-left:10px solid #a2a9b1}.mw-parser-output .ambox .mbox-text{border:none;padding:0.25em 0.5em;width:100%}.mw-parser-output .ambox .mbox-image{border:none;padding:2px 0 2px 0.5em;text-align:center}.mw-parser-output .ambox .mbox-imageright{border:none;padding:2px 0.5em 2px 0;text-align:center}.mw-parser-output .ambox .mbox-empty-cell{border:none;padding:0;width:1px}.mw-parser-output .ambox .mbox-image-div{width:52px}@media(min-width:720px){.mw-parser-output .ambox{margin:0 10%}}@media print{body.ns-0 .mw-parser-output .ambox{display:none!important}}</style><table class="box-Medical_citations_needed plainlinks metadata ambox ambox-content" role="presentation"><tbody><tr><td class="mbox-image"><div class="mbox-image-div"><span typeof="mw:File"><span><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/40px-Ambox_important.svg.png" decoding="async" width="40" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/60px-Ambox_important.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/b/b4/Ambox_important.svg/80px-Ambox_important.svg.png 2x" data-file-width="40" data-file-height="40" /></span></span></div></td><td class="mbox-text"><div class="mbox-text-span">This article <b>needs more <a href="/wiki/Wikipedia:Identifying_reliable_sources_(medicine)" title="Wikipedia:Identifying reliable sources (medicine)">reliable medical references</a> for <a href="/wiki/Wikipedia:Verifiability" title="Wikipedia:Verifiability">verification</a> or relies too heavily on <a href="/wiki/Wikipedia:Primary_sources" class="mw-redirect" title="Wikipedia:Primary sources">primary sources</a></b>.<span class="hide-when-compact"> Please review the contents of the article and <a class="external text" href="https://en.wikipedia.org/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit">add the appropriate references</a> if you can. Unsourced or poorly sourced material may be challenged and <a href="/wiki/Wikipedia:Verifiability#Burden_of_evidence" title="Wikipedia:Verifiability">removed</a>. <small><span class="plainlinks"><i>Find sources:</i> <a rel="nofollow" class="external text" href="https://www.google.com/search?as_eq=wikipedia&q=%22Glucagon-like+peptide-1+receptor%22">"Glucagon-like peptide-1 receptor"</a> – <a rel="nofollow" class="external text" href="https://www.google.com/search?tbm=nws&q=%22Glucagon-like+peptide-1+receptor%22+-wikipedia&tbs=ar:1">news</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?&q=%22Glucagon-like+peptide-1+receptor%22&tbs=bkt:s&tbm=bks">newspapers</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.google.com/search?tbs=bks:1&q=%22Glucagon-like+peptide-1+receptor%22+-wikipedia">books</a> <b>·</b> <a rel="nofollow" class="external text" href="https://scholar.google.com/scholar?q=%22Glucagon-like+peptide-1+receptor%22">scholar</a> <b>·</b> <a rel="nofollow" class="external text" href="https://www.jstor.org/action/doBasicSearch?Query=%22Glucagon-like+peptide-1+receptor%22&acc=on&wc=on">JSTOR</a></span></small></span> <span class="date-container"><i>(<span class="date">January 2024</span>)</i></span></div></td><td class="mbox-imageright"><div class="mbox-image-div"><span typeof="mw:File"><span><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/52px-Star_of_life.svg.png" decoding="async" width="52" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/77px-Star_of_life.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Star_of_life.svg/103px-Star_of_life.svg.png 2x" data-file-width="198" data-file-height="192" /></span></span></div></td></tr></tbody></table> <p>Glucose Control: GLP-1 and its agonists enhance glucose control by promoting insulin secretion from pancreatic beta cells in a glucose-dependent manner. This means that they stimulate insulin release when blood glucose levels are elevated, helping to maintain normal blood sugar levels. By mimicking the physiological actions of GLP-1, GLP-1 receptor agonists effectively lower blood glucose levels, particularly after meals. </p><p>Weight Management: GLP-1 and its agonists have demonstrated the ability to promote weight loss or weight stabilization. These agents help reduce appetite, delay gastric emptying, and enhance satiety, leading to reduced food intake. The weight loss effect is particularly beneficial for individuals with type 2 diabetes who often struggle with obesity or overweight conditions. </p><p>Cardiovascular Protection: GLP-1 receptor agonists have shown potential cardiovascular benefits beyond glucose control. Some studies suggest that these agents may reduce the risk of cardiovascular events, such as heart attacks, strokes, and cardiovascular-related mortality. The cardiovascular protective effects may be related to their favorable effects on blood pressure, lipid profiles, inflammation, and endothelial function. </p><p>Beta Cell Preservation: GLP-1 and its agonists have been found to exert protective effects on pancreatic beta cells, which are responsible for producing insulin. They can enhance beta cell survival, promote beta cell proliferation, and inhibit beta cell apoptosis, thus preserving beta cell function over time. </p><p>Combination Therapy: GLP-1 receptor agonists are often used as part of combination therapy in the treatment of type 2 diabetes. They can be prescribed alongside other oral antidiabetic medications, such as metformin or sulfonylureas, to provide additional glycemic control and improve overall treatment outcomes. </p><p>Different GLP-1 receptor agonists go through inactivation by <a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">dipeptidyl peptidase-4</a> (DPP-4) enzymes (The clinical use of GLP-1 is hampered by its short-half life in the circulation (1-2 min), because of its proteolytic degradation by the enzymes dipeptidyl peptidase-4 (DPP-4) and <a href="/wiki/Neutral_endopeptidase" class="mw-redirect" title="Neutral endopeptidase">neutral endopeptidase</a>). One strategy used for overcoming this problem is by synthesising new GLP-1 receptor agonists with a prolonged circulating <a href="/wiki/Half-life" title="Half-life">half-life</a> that will display a reduced degradation by DPP-4 enzymes. Another strategy is to inihibit DPP-4 enzymes. </p><p>The debate about which treatment in combatting T2D still wages. Some studies suggest GLP1 Receptor Agonists (GLP1RAs) which have shown significant results compared to treatment with DPP-4 inhibitors. Some studies provided an insight into the reduction in limb incidents when treated with GLP1RAs. Other studies showed that GLP1RAs provide superior glycaemic control and weight loss when compared with DPP-4 inhibitors in patients with T2D. </p> <div class="mw-heading mw-heading3"><h3 id="Semaglutide">Semaglutide</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=6" title="Edit section: Semaglutide"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Commercially known as Ozempic (<a href="/wiki/Semaglutide" title="Semaglutide">semaglutide</a>), is a medication that belongs to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 RAs). It is primarily used for the treatment of type 2 diabetes and has shown potential benefits in addressing obesity as well. Semaglutide has an experimented half-life of 183 hours compared with <a href="/wiki/Liraglutide" title="Liraglutide">Liraglutide</a> (15 hours). </p><p>Concerning <a href="/wiki/Obesity" title="Obesity">obesity</a>, semaglutide has also shown effectiveness in treating obesity. In higher doses than those used for diabetes management, it can help reduce body weight. The precise mechanism by which semaglutide induces weight loss is not fully understood, but it is believed to involve various factors. Semaglutide decreases appetite by acting on the brain's centers responsible for appetite regulation, leading to a feeling of fullness and reduced food intake. It also slows down the emptying of the stomach, which can contribute to a decreased caloric intake. These combined effects on appetite and digestion help individuals lose weight. </p><p>The medication is administered as a once-weekly subcutaneous injection. The starting dose is usually low and gradually increased over several weeks to help minimize potential gastrointestinal side effects, such as nausea. The optimal dose for an individual is determined by their healthcare provider based on factors such as blood sugar levels, response to treatment, and tolerability. </p><p>Clinical trials have demonstrated the efficacy of Ozempic in improving glycemic control. The medication has shown significant reductions in HbA1c (a measure of long-term blood sugar control) as well as fasting and postprandial (after-meal) glucose levels. </p><p>Possible Side effects of semaglutide: </p><p>Like any medication, Ozempic may cause side effects. Common side effects include nausea, vomiting, diarrhea, and constipation. These side effects are usually temporary and tend to diminish over time. Rare but more serious side effects may include pancreatitis, gallbladder disease, and allergic reactions. It is essential to discuss potential side effects and risks with a healthcare provider before starting Ozempic. </p> <div class="mw-heading mw-heading3"><h3 id="Huntington's_disease"><span id="Huntington.27s_disease"></span>Huntington's disease</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=7" title="Edit section: Huntington's disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The diabetic, pancreatic, and neuroprotection implications of GLP1R are also thought to be potential therapies for treating the diabetes and energy metabolism abnormalities associated with <a href="/wiki/Huntington%27s_disease" title="Huntington's disease">Huntington's disease</a> affecting the brain and periphery. <a href="/w/index.php?title=Exendin-4&action=edit&redlink=1" class="new" title="Exendin-4 (page does not exist)">Exendin-4</a>, an FDA-approved antidiabetic glucagon-like peptide 1 (GLP-1) receptor agonist, has been tested in mice with the mutated human huntingtin protein showing neurodegenerative changes, motor dysfunction, poor energy metabolism, and high blood glucose levels. Exendin-4 (Ex-4) treatment reduced the accumulation of mutated human huntingtin protein aggregates, improved motor function, extended the survival time, improved glucose regulation, and decreased brain and pancreas pathology.<sup id="cite_ref-Martin_2009_23-0" class="reference"><a href="#cite_note-Martin_2009-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>Exendin-4 increases beta cell mass in the pancreatic islets to improve the release of insulin to ultimately increase glucose uptake. The mechanism regarding this insulin increase involves Ex-4 and GLP-1. When the islets in the pancreas are exposed to GLP-1, there is an increased expression of the anti-apoptotic gene <a href="/wiki/Bcl-2" title="Bcl-2">bcl-2</a> and decreased expression of pro-apoptotic genes <a href="/wiki/Bcl-2-associated_X_protein" class="mw-redirect" title="Bcl-2-associated X protein">bax</a> and <a href="/wiki/Caspase-3" class="mw-redirect" title="Caspase-3">caspase-3</a>, which leads to greater cell survival. GLP-1 binding to its <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptor</a> activates various different pathways including the growth factor receptor and is coupled to pathways stimulating <a href="/wiki/Mitogenesis" class="mw-redirect" title="Mitogenesis">mitogenesis</a>. Some of these pathways include <a href="/wiki/RAP1A" title="RAP1A">Rap</a>, <a href="/wiki/Extracellular_signal-regulated_kinases" title="Extracellular signal-regulated kinases">Erk1/2</a>, <a href="/wiki/Mitogen-activated_protein_kinase" title="Mitogen-activated protein kinase">MAPK</a>, <a href="/wiki/B-RAF" class="mw-redirect" title="B-RAF">B-RAF</a>, <a href="/wiki/PI3-K" class="mw-redirect" title="PI3-K">PI3-K</a>, <a href="/wiki/Cyclic_adenosine_monophosphate" title="Cyclic adenosine monophosphate">cAMP</a>, <a href="/wiki/Protein_kinase_A" title="Protein kinase A">PKA</a>, and <a href="/wiki/CRTC2" title="CRTC2">TORC2</a> that are activated to initiate <a href="/wiki/Exocytosis" title="Exocytosis">exocytosis</a>, proinsulin gene expression and translation, increase insulin biosynthesis, and genetically increase beta cell proliferation and neogenesis. The GLP-1R is a G protein-coupled receptor that is dependent on glucose and GLP-1 is a peptide hormone that acts directly on the beta cell to stimulate insulin secretion by activating signal transduction when glucose is present. When glucose is not present, this receptor no longer couples to stimulate insulin secretion in order to prevent hypoglycemia.<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p><p>Relating glucose metabolism and insulin sensitivity back to Huntington's disease, increased insulin release and beta cell proliferation by a GLP-1 agonist, Ex-4, helps combat the damage done by mutant <a href="/wiki/Huntingtin" title="Huntingtin">htt</a> in peripheral tissues. Htt aggregation decreases beta cell mass and thus impairs insulin release and increases blood glucose levels. Disruption of glycemic homeostasis then affects nutrient availability to neurons and alters neuron function contributing to neurodegeneration and motor problems seen in Huntington's disease. The health of the nervous system is related to metabolic health, thus a diabetes medication as a Huntington's disease treatment is a potential treatment. Ex-4 easily crosses the blood-brain barrier and GLP-1 and Ex-4 have been shown to act on neurons in the brain by exerting neuroprotective actions.<sup id="cite_ref-Martin_2009_23-1" class="reference"><a href="#cite_note-Martin_2009-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>In studies with Huntington's disease mice, daily treatments of Ex-4 significantly reduced glucose levels compared to those mice treated with saline. It also increased insulin sensitivity by about 50%, improved insulin-stimulated glucose uptake, and protect pancreatic beta cell function. Huntington's disease has also been linked to imbalances in <a href="/wiki/Leptin" title="Leptin">leptin</a> and <a href="/wiki/Ghrelin" title="Ghrelin">ghrelin</a> levels. Ex-4 restored ghrelin levels and also lowered leptin levels allowing Huntington's disease mice to eat more and counteract symptomatic weight loss. This treatment restored beta cell cells and islet structure, reduce mutated human huntingtin aggregates in the brain and pancreas, and also improve motor function seen by the increased activity level of the mice. Improvements were found in the areas of the body that expressed GLP-1R. In addition to its other effects on the Huntington's disease mouse model, daily treatment of Ex-4, the GLP-1R agonist, significantly delayed the onset of mortality and extended the lifespan by approximately one month.<sup id="cite_ref-Martin_2009_23-2" class="reference"><a href="#cite_note-Martin_2009-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=8" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Glucagon-like_peptide-1" title="Glucagon-like peptide-1">Glucagon-like peptide-1</a></li> <li><a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">Dipeptidyl peptidase-4</a></li></ul> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=9" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 32em;"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000112164">GRCh38: Ensembl release 89: ENSG00000112164</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000024027">GRCm38: Ensembl release 89: ENSMUSG00000024027</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=2740">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D2740&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=14652">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D14652&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid1326760-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1326760_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFThorens1992" class="citation journal cs1">Thorens B (September 1992). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49976">"Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>89</b> (18): 8641–5. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1992PNAS...89.8641T">1992PNAS...89.8641T</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.89.18.8641">10.1073/pnas.89.18.8641</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49976">49976</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1326760">1326760</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Expression+cloning+of+the+pancreatic+beta+cell+receptor+for+the+gluco-incretin+hormone+glucagon-like+peptide+1&rft.volume=89&rft.issue=18&rft.pages=8641-5&rft.date=1992-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC49976%23id-name%3DPMC&rft_id=info%3Apmid%2F1326760&rft_id=info%3Adoi%2F10.1073%2Fpnas.89.18.8641&rft_id=info%3Abibcode%2F1992PNAS...89.8641T&rft.aulast=Thorens&rft.aufirst=B&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC49976&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid8404634-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid8404634_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDillonTanizawaWheelerLeng1993" class="citation journal cs1">Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, et al. (October 1993). "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor". <i>Endocrinology</i>. <b>133</b> (4): 1907–10. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fendo.133.4.8404634">10.1210/endo.133.4.8404634</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8404634">8404634</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Cloning+and+functional+expression+of+the+human+glucagon-like+peptide-1+%28GLP-1%29+receptor&rft.volume=133&rft.issue=4&rft.pages=1907-10&rft.date=1993-10&rft_id=info%3Adoi%2F10.1210%2Fendo.133.4.8404634&rft_id=info%3Apmid%2F8404634&rft.aulast=Dillon&rft.aufirst=JS&rft.au=Tanizawa%2C+Y&rft.au=Wheeler%2C+MB&rft.au=Leng%2C+XH&rft.au=Ligon%2C+BB&rft.au=Rabin%2C+DU&rft.au=Yoo-Warren%2C+H&rft.au=Permutt%2C+MA&rft.au=Boyd%2C+AE&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid12529935-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12529935_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBrubakerDrucker2002" class="citation journal cs1">Brubaker PL, Drucker DJ (2002). <a rel="nofollow" class="external text" href="http://www.glucagon.com/pdfs/Receptors%20and%20Channels.pdf">"Structure-function of the glucagon receptor family of G protein-coupled receptors, coupled to: the glucagon, GIP, GLP-1, and GLP-2 receptors"</a> <span class="cs1-format">(PDF)</span>. <i>Receptors & Channels</i>. <b>8</b> (3–4): 179–88. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F10606820213687">10.1080/10606820213687</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12529935">12529935</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Receptors+%26+Channels&rft.atitle=Structure-function+of+the+glucagon+receptor+family+of+G+protein-coupled+receptors%2C+coupled+to%3A+the+glucagon%2C+GIP%2C+GLP-1%2C+and+GLP-2+receptors&rft.volume=8&rft.issue=3%E2%80%934&rft.pages=179-88&rft.date=2002&rft_id=info%3Adoi%2F10.1080%2F10606820213687&rft_id=info%3Apmid%2F12529935&rft.aulast=Brubaker&rft.aufirst=PL&rft.au=Drucker%2C+DJ&rft_id=http%3A%2F%2Fwww.glucagon.com%2Fpdfs%2FReceptors%2520and%2520Channels.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid27059958-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid27059958_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFUnderwoodGaribayKnudsenHastrup2010" class="citation journal cs1">Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S (January 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804221">"Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor"</a>. <i>The Journal of Biological Chemistry</i>. <b>285</b> (1): 723–30. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M109.033829">10.1074/jbc.M109.033829</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804221">2804221</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19861722">19861722</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Crystal+structure+of+glucagon-like+peptide-1+in+complex+with+the+extracellular+domain+of+the+glucagon-like+peptide-1+receptor&rft.volume=285&rft.issue=1&rft.pages=723-30&rft.date=2010-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2804221%23id-name%3DPMC&rft_id=info%3Apmid%2F19861722&rft_id=info%3Adoi%2F10.1074%2Fjbc.M109.033829&rft.aulast=Underwood&rft.aufirst=CR&rft.au=Garibay%2C+P&rft.au=Knudsen%2C+LB&rft.au=Hastrup%2C+S&rft.au=Peters%2C+GH&rft.au=Rudolph%2C+R&rft.au=Reedtz-Runge%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2804221&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-doi10.1038/nature22378-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-doi10.1038/nature22378_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSongYangWangde_Graaf2017" class="citation journal cs1">Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, et al. (June 2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators". <i>Nature</i>. <b>546</b> (7657): 312–315. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2017Natur.546..312S">2017Natur.546..312S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature22378">10.1038/nature22378</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28514449">28514449</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:2141649">2141649</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Human+GLP-1+receptor+transmembrane+domain+structure+in+complex+with+allosteric+modulators&rft.volume=546&rft.issue=7657&rft.pages=312-315&rft.date=2017-06&rft_id=info%3Adoi%2F10.1038%2Fnature22378&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A2141649%23id-name%3DS2CID&rft_id=info%3Apmid%2F28514449&rft_id=info%3Abibcode%2F2017Natur.546..312S&rft.aulast=Song&rft.aufirst=G&rft.au=Yang%2C+D&rft.au=Wang%2C+Y&rft.au=de+Graaf%2C+C&rft.au=Zhou%2C+Q&rft.au=Jiang%2C+S&rft.au=Liu%2C+K&rft.au=Cai%2C+X&rft.au=Dai%2C+A&rft.au=Lin%2C+G&rft.au=Liu%2C+D&rft.au=Wu%2C+F&rft.au=Wu%2C+Y&rft.au=Zhao%2C+S&rft.au=Ye%2C+L&rft.au=Han%2C+GW&rft.au=Lau%2C+J&rft.au=Wu%2C+B&rft.au=Hanson%2C+MA&rft.au=Liu%2C+ZJ&rft.au=Wang%2C+MW&rft.au=Stevens%2C+RC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid26700562-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid26700562_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid26700562_10-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWoottenReynoldsKooleSmith2016" class="citation journal cs1">Wootten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, et al. (March 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767408">"A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures"</a>. <i>Molecular Pharmacology</i>. <b>89</b> (3): 335–47. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1124%2Fmol.115.101246">10.1124/mol.115.101246</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4767408">4767408</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26700562">26700562</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=A+Hydrogen-Bonded+Polar+Network+in+the+Core+of+the+Glucagon-Like+Peptide-1+Receptor+Is+a+Fulcrum+for+Biased+Agonism%3A+Lessons+from+Class+B+Crystal+Structures&rft.volume=89&rft.issue=3&rft.pages=335-47&rft.date=2016-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4767408%23id-name%3DPMC&rft_id=info%3Apmid%2F26700562&rft_id=info%3Adoi%2F10.1124%2Fmol.115.101246&rft.aulast=Wootten&rft.aufirst=D&rft.au=Reynolds%2C+CA&rft.au=Koole%2C+C&rft.au=Smith%2C+KJ&rft.au=Mobarec%2C+JC&rft.au=Simms%2C+J&rft.au=Quon%2C+T&rft.au=Coudrat%2C+T&rft.au=Furness%2C+SG&rft.au=Miller%2C+LJ&rft.au=Christopoulos%2C+A&rft.au=Sexton%2C+PM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4767408&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid27315480-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid27315480_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid27315480_11-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWoottenReynoldsSmithMobarec2016" class="citation journal cs1">Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Koole C, Savage EE, et al. (June 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912689">"The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism"</a>. <i>Cell</i>. <b>165</b> (7): 1632–1643. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2016.05.023">10.1016/j.cell.2016.05.023</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912689">4912689</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27315480">27315480</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=The+Extracellular+Surface+of+the+GLP-1+Receptor+Is+a+Molecular+Trigger+for+Biased+Agonism&rft.volume=165&rft.issue=7&rft.pages=1632-1643&rft.date=2016-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4912689%23id-name%3DPMC&rft_id=info%3Apmid%2F27315480&rft_id=info%3Adoi%2F10.1016%2Fj.cell.2016.05.023&rft.aulast=Wootten&rft.aufirst=D&rft.au=Reynolds%2C+CA&rft.au=Smith%2C+KJ&rft.au=Mobarec%2C+JC&rft.au=Koole%2C+C&rft.au=Savage%2C+EE&rft.au=Pabreja%2C+K&rft.au=Simms%2C+J&rft.au=Sridhar%2C+R&rft.au=Furness%2C+SG&rft.au=Liu%2C+M&rft.au=Thompson%2C+PE&rft.au=Miller%2C+LJ&rft.au=Christopoulos%2C+A&rft.au=Sexton%2C+PM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4912689&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid19861722-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19861722_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYangde_GraafYangSong2016" class="citation journal cs1">Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, et al. (June 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933217">"Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)"</a>. <i>The Journal of Biological Chemistry</i>. <b>291</b> (25): 12991–3004. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M116.721977">10.1074/jbc.M116.721977</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933217">4933217</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27059958">27059958</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Structural+Determinants+of+Binding+the+Seven-transmembrane+Domain+of+the+Glucagon-like+Peptide-1+Receptor+%28GLP-1R%29&rft.volume=291&rft.issue=25&rft.pages=12991-3004&rft.date=2016-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4933217%23id-name%3DPMC&rft_id=info%3Apmid%2F27059958&rft_id=info%3Adoi%2F10.1074%2Fjbc.M116.721977&rft.aulast=Yang&rft.aufirst=D&rft.au=de+Graaf%2C+C&rft.au=Yang%2C+L&rft.au=Song%2C+G&rft.au=Dai%2C+A&rft.au=Cai%2C+X&rft.au=Feng%2C+Y&rft.au=Reedtz-Runge%2C+S&rft.au=Hanson%2C+MA&rft.au=Yang%2C+H&rft.au=Jiang%2C+H&rft.au=Stevens%2C+RC&rft.au=Wang%2C+MW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4933217&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid27569426-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid27569426_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWoottenReynoldsSmithMobarec2016" class="citation journal cs1">Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, et al. (October 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063953">"Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor"</a>. <i>Biochemical Pharmacology</i>. <b>118</b>: 68–87. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bcp.2016.08.015">10.1016/j.bcp.2016.08.015</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063953">5063953</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27569426">27569426</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Key+interactions+by+conserved+polar+amino+acids+located+at+the+transmembrane+helical+boundaries+in+Class+B+GPCRs+modulate+activation%2C+effector+specificity+and+biased+signalling+in+the+glucagon-like+peptide-1+receptor&rft.volume=118&rft.pages=68-87&rft.date=2016-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5063953%23id-name%3DPMC&rft_id=info%3Apmid%2F27569426&rft_id=info%3Adoi%2F10.1016%2Fj.bcp.2016.08.015&rft.aulast=Wootten&rft.aufirst=D&rft.au=Reynolds%2C+CA&rft.au=Smith%2C+KJ&rft.au=Mobarec%2C+JC&rft.au=Furness%2C+SG&rft.au=Miller%2C+LJ&rft.au=Christopoulos%2C+A&rft.au=Sexton%2C+PM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5063953&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-IUPHAR_2015_GLP-1-14"><span class="mw-cite-backlink">^ <a href="#cite_ref-IUPHAR_2015_GLP-1_14-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-IUPHAR_2015_GLP-1_14-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-IUPHAR_2015_GLP-1_14-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-IUPHAR_2015_GLP-1_14-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-IUPHAR_2015_GLP-1_14-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-IUPHAR_2015_GLP-1_14-5"><sup><i><b>f</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMaguireDavenport" class="citation web cs1">Maguire JJ, Davenport AP. <a rel="nofollow" class="external text" href="http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=249">"GLP-1 receptor"</a>. <i>IUPHAR/BPS Guide to PHARMACOLOGY</i>. International Union of Basic and Clinical Pharmacology<span class="reference-accessdate">. Retrieved <span class="nowrap">13 September</span> 2015</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=IUPHAR%2FBPS+Guide+to+PHARMACOLOGY&rft.atitle=GLP-1+receptor&rft.aulast=Maguire&rft.aufirst=JJ&rft.au=Davenport%2C+AP&rft_id=http%3A%2F%2Fwww.guidetopharmacology.org%2FGRAC%2FObjectDisplayForward%3FobjectId%3D249&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid28283573-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid28283573_15-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKooleReynoldsMobarecHick2017" class="citation journal cs1">Koole C, Reynolds CA, Mobarec JC, Hick C, Sexton PM, Sakmar TP (April 2017). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409479">"Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)"</a>. <i>The Journal of Biological Chemistry</i>. <b>292</b> (17): 7131–7144. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M117.779496">10.1074/jbc.M117.779496</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409479">5409479</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28283573">28283573</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Genetically+encoded+photocross-linkers+determine+the+biological+binding+site+of+exendin-4+peptide+in+the+N-terminal+domain+of+the+intact+human+glucagon-like+peptide-1+receptor+%28GLP-1R%29&rft.volume=292&rft.issue=17&rft.pages=7131-7144&rft.date=2017-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5409479%23id-name%3DPMC&rft_id=info%3Apmid%2F28283573&rft_id=info%3Adoi%2F10.1074%2Fjbc.M117.779496&rft.aulast=Koole&rft.aufirst=C&rft.au=Reynolds%2C+CA&rft.au=Mobarec%2C+JC&rft.au=Hick%2C+C&rft.au=Sexton%2C+PM&rft.au=Sakmar%2C+TP&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5409479&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-IU*PHAR_2015_GLP-1-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-IU*PHAR_2015_GLP-1_16-0">^</a></b></span> <span class="error mw-ext-cite-error" lang="en" dir="ltr">Cite error: The named reference <code>IU*PHAR 2015 GLP-1</code> was invoked but never defined (see the <a href="/wiki/Help:Cite_errors/Cite_error_references_no_text" title="Help:Cite errors/Cite error references no text">help page</a>).</span></li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBiggsLiangNaylorMadalli2018" class="citation journal cs1">Biggs EK, Liang L, Naylor J, Madalli S, Collier R, Coghlan MP, et al. (March 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890879">"Development and characterisation of a novel glucagon like peptide-1 receptor antibody"</a>. <i>Diabetologia</i>. <b>61</b> (3): 711–721. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00125-017-4491-0">10.1007/s00125-017-4491-0</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5890879">5890879</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29119245">29119245</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diabetologia&rft.atitle=Development+and+characterisation+of+a+novel+glucagon+like+peptide-1+receptor+antibody&rft.volume=61&rft.issue=3&rft.pages=711-721&rft.date=2018-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5890879%23id-name%3DPMC&rft_id=info%3Apmid%2F29119245&rft_id=info%3Adoi%2F10.1007%2Fs00125-017-4491-0&rft.aulast=Biggs&rft.aufirst=EK&rft.au=Liang%2C+L&rft.au=Naylor%2C+J&rft.au=Madalli%2C+S&rft.au=Collier%2C+R&rft.au=Coghlan%2C+MP&rft.au=Baker%2C+DJ&rft.au=Hornigold%2C+DC&rft.au=Ravn%2C+P&rft.au=Reimann%2C+F&rft.au=Gribble%2C+FM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5890879&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFO'BrienAndrewsBaigBortolato2019" class="citation journal cs1">O'Brien A, Andrews S, Baig AH, Bortolato A, Brown JH, Brown GA, et al. (2019-08-09). "Identification of a novel allosteric GLP–1R antagonist HTL26119 using structure-based drug design". <i>Bioorganic & Medicinal Chemistry Letters</i>. <b>29</b> (20): 126611. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.bmcl.2019.08.015">10.1016/j.bmcl.2019.08.015</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31447084">31447084</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:201749908">201749908</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bioorganic+%26+Medicinal+Chemistry+Letters&rft.atitle=Identification+of+a+novel+allosteric+GLP%E2%80%931R+antagonist+HTL26119+using+structure-based+drug+design&rft.volume=29&rft.issue=20&rft.pages=126611&rft.date=2019-08-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A201749908%23id-name%3DS2CID&rft_id=info%3Apmid%2F31447084&rft_id=info%3Adoi%2F10.1016%2Fj.bmcl.2019.08.015&rft.aulast=O%27Brien&rft.aufirst=A&rft.au=Andrews%2C+S&rft.au=Baig%2C+AH&rft.au=Bortolato%2C+A&rft.au=Brown%2C+JH&rft.au=Brown%2C+GA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid26500843-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid26500843_19-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCorkRichardsHoltGribble2015" class="citation journal cs1">Cork SC, Richards JE, Holt MK, Gribble FM, Reimann F, Trapp S (October 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588458">"Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain"</a>. <i>Molecular Metabolism</i>. <b>4</b> (10): 718–31. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.molmet.2015.07.008">10.1016/j.molmet.2015.07.008</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588458">4588458</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26500843">26500843</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Metabolism&rft.atitle=Distribution+and+characterisation+of+Glucagon-like+peptide-1+receptor+expressing+cells+in+the+mouse+brain&rft.volume=4&rft.issue=10&rft.pages=718-31&rft.date=2015-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4588458%23id-name%3DPMC&rft_id=info%3Apmid%2F26500843&rft_id=info%3Adoi%2F10.1016%2Fj.molmet.2015.07.008&rft.aulast=Cork&rft.aufirst=SC&rft.au=Richards%2C+JE&rft.au=Holt%2C+MK&rft.au=Gribble%2C+FM&rft.au=Reimann%2C+F&rft.au=Trapp%2C+S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4588458&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid12451146-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12451146_20-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKinzigD'AlessioSeeley2002" class="citation journal cs1">Kinzig KP, D'Alessio DA, <a href="/wiki/Randy_Seeley" title="Randy Seeley">Seeley RJ</a> (December 2002). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758755">"The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness"</a>. <i>The Journal of Neuroscience</i>. <b>22</b> (23): 10470–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.22-23-10470.2002">10.1523/JNEUROSCI.22-23-10470.2002</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758755">6758755</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12451146">12451146</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=The+diverse+roles+of+specific+GLP-1+receptors+in+the+control+of+food+intake+and+the+response+to+visceral+illness&rft.volume=22&rft.issue=23&rft.pages=10470-6&rft.date=2002-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6758755%23id-name%3DPMC&rft_id=info%3Apmid%2F12451146&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.22-23-10470.2002&rft.aulast=Kinzig&rft.aufirst=KP&rft.au=D%27Alessio%2C+DA&rft.au=Seeley%2C+RJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6758755&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-pmid12925848-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12925848_21-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDuringCaoZuzgaFrancis2003" class="citation journal cs1">During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, et al. (September 2003). "Glucagon-like peptide-1 receptor is involved in learning and neuroprotection". <i>Nature Medicine</i>. <b>9</b> (9): 1173–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnm919">10.1038/nm919</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12925848">12925848</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:10370218">10370218</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Glucagon-like+peptide-1+receptor+is+involved+in+learning+and+neuroprotection&rft.volume=9&rft.issue=9&rft.pages=1173-9&rft.date=2003-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A10370218%23id-name%3DS2CID&rft_id=info%3Apmid%2F12925848&rft_id=info%3Adoi%2F10.1038%2Fnm919&rft.aulast=During&rft.aufirst=MJ&rft.au=Cao%2C+L&rft.au=Zuzga%2C+DS&rft.au=Francis%2C+JS&rft.au=Fitzsimons%2C+HL&rft.au=Jiao%2C+X&rft.au=Bland%2C+RJ&rft.au=Klugmann%2C+M&rft.au=Banks%2C+WA&rft.au=Drucker%2C+DJ&rft.au=Haile%2C+CN&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-Williams_2016-22"><span class="mw-cite-backlink">^ <a href="#cite_ref-Williams_2016_22-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Williams_2016_22-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWilliamsChangStrochlicUmans2016" class="citation journal cs1">Williams EK, Chang RB, Strochlic DE, Umans BD, Lowell BB, Liberles SD (June 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930427">"Sensory Neurons that Detect Stretch and Nutrients in the Digestive System"</a>. <i>Cell</i>. <b>166</b> (1): 209–21. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.cell.2016.05.011">10.1016/j.cell.2016.05.011</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930427">4930427</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27238020">27238020</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Sensory+Neurons+that+Detect+Stretch+and+Nutrients+in+the+Digestive+System&rft.volume=166&rft.issue=1&rft.pages=209-21&rft.date=2016-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4930427%23id-name%3DPMC&rft_id=info%3Apmid%2F27238020&rft_id=info%3Adoi%2F10.1016%2Fj.cell.2016.05.011&rft.aulast=Williams&rft.aufirst=EK&rft.au=Chang%2C+RB&rft.au=Strochlic%2C+DE&rft.au=Umans%2C+BD&rft.au=Lowell%2C+BB&rft.au=Liberles%2C+SD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4930427&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-Martin_2009-23"><span class="mw-cite-backlink">^ <a href="#cite_ref-Martin_2009_23-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Martin_2009_23-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Martin_2009_23-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMartinGoldenCarlsonPistell2009" class="citation journal cs1">Martin B, Golden E, Carlson OD, Pistell P, Zhou J, Kim W, et al. (February 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628604">"Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease"</a>. <i>Diabetes</i>. <b>58</b> (2): 318–28. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2337%2Fdb08-0799">10.2337/db08-0799</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628604">2628604</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18984744">18984744</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Exendin-4+improves+glycemic+control%2C+ameliorates+brain+and+pancreatic+pathologies%2C+and+extends+survival+in+a+mouse+model+of+Huntington%27s+disease&rft.volume=58&rft.issue=2&rft.pages=318-28&rft.date=2009-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2628604%23id-name%3DPMC&rft_id=info%3Apmid%2F18984744&rft_id=info%3Adoi%2F10.2337%2Fdb08-0799&rft.aulast=Martin&rft.aufirst=B&rft.au=Golden%2C+E&rft.au=Carlson%2C+OD&rft.au=Pistell%2C+P&rft.au=Zhou%2C+J&rft.au=Kim%2C+W&rft.au=Frank%2C+BP&rft.au=Thomas%2C+S&rft.au=Chadwick%2C+WA&rft.au=Greig%2C+NH&rft.au=Bates%2C+GP&rft.au=Sathasivam%2C+K&rft.au=Bernier%2C+M&rft.au=Maudsley%2C+S&rft.au=Mattson%2C+MP&rft.au=Egan%2C+JM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2628604&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> <li id="cite_note-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-24">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDrucker_DJ" class="citation web cs1">Drucker DJ. <a rel="nofollow" class="external text" href="http://www.medscape.org/viewarticle/544820_2">"Resurrecting the Beta Cell in Type 2 Diabetes: Beta-cell Function, Preservation, and Neogenesis"</a>. <i>PowerPoint slides</i>. Medscape.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=PowerPoint+slides&rft.atitle=Resurrecting+the+Beta+Cell+in+Type+2+Diabetes%3A+Beta-cell+Function%2C+Preservation%2C+and+Neogenesis&rft.au=Drucker+DJ&rft_id=http%3A%2F%2Fwww.medscape.org%2Fviewarticle%2F544820_2&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=10" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 32em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFvan_EyllLankat-ButtgereitBodeGöke1994" class="citation journal cs1">van Eyll B, Lankat-Buttgereit B, Bode HP, Göke R, Göke B (July 1994). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2894%2900553-2">"Signal transduction of the GLP-1-receptor cloned from a human insulinoma"</a>. <i>FEBS Letters</i>. <b>348</b> (1): 7–13. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1994FEBSL.348....7V">1994FEBSL.348....7V</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2894%2900553-2">10.1016/0014-5793(94)00553-2</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7517895">7517895</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9085188">9085188</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Signal+transduction+of+the+GLP-1-receptor+cloned+from+a+human+insulinoma&rft.volume=348&rft.issue=1&rft.pages=7-13&rft.date=1994-07&rft_id=info%3Adoi%2F10.1016%2F0014-5793%2894%2900553-2&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A9085188%23id-name%3DS2CID&rft_id=info%3Apmid%2F7517895&rft_id=info%3Abibcode%2F1994FEBSL.348....7V&rft.aulast=van+Eyll&rft.aufirst=B&rft.au=Lankat-Buttgereit%2C+B&rft.au=Bode%2C+HP&rft.au=G%C3%B6ke%2C+R&rft.au=G%C3%B6ke%2C+B&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0014-5793%252894%252900553-2&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLiuSunXieLi2022" class="citation journal cs1">Liu C, Sun S, Xie J, Li H, Li T, Wu Q, Zhang Y, Bai X, Wang J, Wang X, Li Z, Wang W (2022). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148281">"GLP-1R Agonist Exendin-4 Protects Against Hemorrhagic Transformation Induced by rtPA After Ischemic Stroke via the Wnt/β-Catenin Signaling Pathway"</a>. <i>Mol Neurobiol</i>. <b>59</b> (6): 3649–3664. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs12035-022-02811-9">10.1007/s12035-022-02811-9</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9148281">9148281</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/35359227">35359227</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mol+Neurobiol&rft.atitle=GLP-1R+Agonist+Exendin-4+Protects+Against+Hemorrhagic+Transformation+Induced+by+rtPA+After+Ischemic+Stroke+via+the+Wnt%2F%CE%B2-Catenin+Signaling+Pathway&rft.volume=59&rft.issue=6&rft.pages=3649-3664&rft.date=2022&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9148281%23id-name%3DPMC&rft_id=info%3Apmid%2F35359227&rft_id=info%3Adoi%2F10.1007%2Fs12035-022-02811-9&rft.aulast=Liu&rft.aufirst=C&rft.au=Sun%2C+S&rft.au=Xie%2C+J&rft.au=Li%2C+H&rft.au=Li%2C+T&rft.au=Wu%2C+Q&rft.au=Zhang%2C+Y&rft.au=Bai%2C+X&rft.au=Wang%2C+J&rft.au=Wang%2C+X&rft.au=Li%2C+Z&rft.au=Wang%2C+W&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC9148281&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGromadaRorsmanDissingWulff1995" class="citation journal cs1">Gromada J, Rorsman P, Dissing S, Wulff BS (October 1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2895%2901070-U">"Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release"</a>. <i>FEBS Letters</i>. <b>373</b> (2): 182–6. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1995FEBSL.373..182G">1995FEBSL.373..182G</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2895%2901070-U">10.1016/0014-5793(95)01070-U</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7589461">7589461</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:28488846">28488846</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Stimulation+of+cloned+human+glucagon-like+peptide+1+receptor+expressed+in+HEK+293+cells+induces+cAMP-dependent+activation+of+calcium-induced+calcium+release&rft.volume=373&rft.issue=2&rft.pages=182-6&rft.date=1995-10&rft_id=info%3Adoi%2F10.1016%2F0014-5793%2895%2901070-U&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A28488846%23id-name%3DS2CID&rft_id=info%3Apmid%2F7589461&rft_id=info%3Abibcode%2F1995FEBSL.373..182G&rft.aulast=Gromada&rft.aufirst=J&rft.au=Rorsman%2C+P&rft.au=Dissing%2C+S&rft.au=Wulff%2C+BS&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0014-5793%252895%252901070-U&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWeiMojsov1995" class="citation journal cs1">Wei Y, Mojsov S (January 1995). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2894%2901430-9">"Tissue-specific expression of the human receptor for glucagon-like peptide-I: brain, heart and pancreatic forms have the same deduced amino acid sequences"</a>. <i>FEBS Letters</i>. <b>358</b> (3): 219–24. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1995FEBSL.358..219W">1995FEBSL.358..219W</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0014-5793%2894%2901430-9">10.1016/0014-5793(94)01430-9</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7843404">7843404</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:44371465">44371465</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Tissue-specific+expression+of+the+human+receptor+for+glucagon-like+peptide-I%3A+brain%2C+heart+and+pancreatic+forms+have+the+same+deduced+amino+acid+sequences&rft.volume=358&rft.issue=3&rft.pages=219-24&rft.date=1995-01&rft_id=info%3Adoi%2F10.1016%2F0014-5793%2894%2901430-9&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A44371465%23id-name%3DS2CID&rft_id=info%3Apmid%2F7843404&rft_id=info%3Abibcode%2F1995FEBSL.358..219W&rft.aulast=Wei&rft.aufirst=Y&rft.au=Mojsov%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252F0014-5793%252894%252901430-9&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLankat-ButtgereitGökeStöckmannJiang1994" class="citation journal cs1">Lankat-Buttgereit B, Göke R, Stöckmann F, Jiang J, Fehmann HC, Göke B (1994). "Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes". <i>Digestion</i>. <b>55</b> (1): 29–33. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1159%2F000201119">10.1159/000201119</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8112494">8112494</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Digestion&rft.atitle=Detection+of+the+human+glucagon-like+peptide+1%287-36%29+amide+receptor+on+insulinoma-derived+cell+membranes&rft.volume=55&rft.issue=1&rft.pages=29-33&rft.date=1994&rft_id=info%3Adoi%2F10.1159%2F000201119&rft_id=info%3Apmid%2F8112494&rft.aulast=Lankat-Buttgereit&rft.aufirst=B&rft.au=G%C3%B6ke%2C+R&rft.au=St%C3%B6ckmann%2C+F&rft.au=Jiang%2C+J&rft.au=Fehmann%2C+HC&rft.au=G%C3%B6ke%2C+B&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGrazianoHeyBorkowskiChicchi1993" class="citation journal cs1">Graziano MP, Hey PJ, Borkowski D, Chicchi GG, Strader CD (October 1993). "Cloning and functional expression of a human glucagon-like peptide-1 receptor". <i>Biochemical and Biophysical Research Communications</i>. <b>196</b> (1): 141–6. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.1993.2226">10.1006/bbrc.1993.2226</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8216285">8216285</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Cloning+and+functional+expression+of+a+human+glucagon-like+peptide-1+receptor&rft.volume=196&rft.issue=1&rft.pages=141-6&rft.date=1993-10&rft_id=info%3Adoi%2F10.1006%2Fbbrc.1993.2226&rft_id=info%3Apmid%2F8216285&rft.aulast=Graziano&rft.aufirst=MP&rft.au=Hey%2C+PJ&rft.au=Borkowski%2C+D&rft.au=Chicchi%2C+GG&rft.au=Strader%2C+CD&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStoffelEspinosaLe_BeauBell1993" class="citation journal cs1">Stoffel M, Espinosa R, Le Beau MM, Bell GI (August 1993). "Human glucagon-like peptide-1 receptor gene. Localization to chromosome band 6p21 by fluorescence in situ hybridization and linkage of a highly polymorphic simple tandem repeat DNA polymorphism to other markers on chromosome 6". <i>Diabetes</i>. <b>42</b> (8): 1215–8. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2337%2Fdiabetes.42.8.1215">10.2337/diabetes.42.8.1215</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8392011">8392011</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Human+glucagon-like+peptide-1+receptor+gene.+Localization+to+chromosome+band+6p21+by+fluorescence+in+situ+hybridization+and+linkage+of+a+highly+polymorphic+simple+tandem+repeat+DNA+polymorphism+to+other+markers+on+chromosome+6&rft.volume=42&rft.issue=8&rft.pages=1215-8&rft.date=1993-08&rft_id=info%3Adoi%2F10.2337%2Fdiabetes.42.8.1215&rft_id=info%3Apmid%2F8392011&rft.aulast=Stoffel&rft.aufirst=M&rft.au=Espinosa%2C+R&rft.au=Le+Beau%2C+MM&rft.au=Bell%2C+GI&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDillonTanizawaWheelerLeng1993" class="citation journal cs1">Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, et al. (October 1993). "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor". <i>Endocrinology</i>. <b>133</b> (4): 1907–10. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fendo.133.4.8404634">10.1210/endo.133.4.8404634</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8404634">8404634</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Cloning+and+functional+expression+of+the+human+glucagon-like+peptide-1+%28GLP-1%29+receptor&rft.volume=133&rft.issue=4&rft.pages=1907-10&rft.date=1993-10&rft_id=info%3Adoi%2F10.1210%2Fendo.133.4.8404634&rft_id=info%3Apmid%2F8404634&rft.aulast=Dillon&rft.aufirst=JS&rft.au=Tanizawa%2C+Y&rft.au=Wheeler%2C+MB&rft.au=Leng%2C+XH&rft.au=Ligon%2C+BB&rft.au=Rabin%2C+DU&rft.au=Yoo-Warren%2C+H&rft.au=Permutt%2C+MA&rft.au=Boyd%2C+AE&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFThorensPorretBühlerDeng1993" class="citation journal cs1">Thorens B, Porret A, Bühler L, Deng SP, Morel P, Widmann C (November 1993). "Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor". <i>Diabetes</i>. <b>42</b> (11): 1678–82. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2337%2Fdiabetes.42.11.1678">10.2337/diabetes.42.11.1678</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8405712">8405712</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Cloning+and+functional+expression+of+the+human+islet+GLP-1+receptor.+Demonstration+that+exendin-4+is+an+agonist+and+exendin-%289-39%29+an+antagonist+of+the+receptor&rft.volume=42&rft.issue=11&rft.pages=1678-82&rft.date=1993-11&rft_id=info%3Adoi%2F10.2337%2Fdiabetes.42.11.1678&rft_id=info%3Apmid%2F8405712&rft.aulast=Thorens&rft.aufirst=B&rft.au=Porret%2C+A&rft.au=B%C3%BChler%2C+L&rft.au=Deng%2C+SP&rft.au=Morel%2C+P&rft.au=Widmann%2C+C&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLankat-ButtgereitGöke1997" class="citation journal cs1">Lankat-Buttgereit B, Göke B (1997). "Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene". <i>Peptides</i>. <b>18</b> (5): 617–24. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0196-9781%2897%2900001-6">10.1016/S0196-9781(97)00001-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9213353">9213353</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:29733898">29733898</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Peptides&rft.atitle=Cloning+and+characterization+of+the+5%27+flanking+sequences+%28promoter+region%29+of+the+human+GLP-1+receptor+gene&rft.volume=18&rft.issue=5&rft.pages=617-24&rft.date=1997&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A29733898%23id-name%3DS2CID&rft_id=info%3Apmid%2F9213353&rft_id=info%3Adoi%2F10.1016%2FS0196-9781%2897%2900001-6&rft.aulast=Lankat-Buttgereit&rft.aufirst=B&rft.au=G%C3%B6ke%2C+B&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFrimurerBywater1999" class="citation journal cs1">Frimurer TM, Bywater RP (June 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F%28SICI%291097-0134%2819990601%2935%3A4%3C375%3A%3AAID-PROT1%3E3.0.CO%3B2-2">"Structure of the integral membrane domain of the GLP1 receptor"</a>. <i>Proteins</i>. <b>35</b> (4): 375–86. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2F%28SICI%291097-0134%2819990601%2935%3A4%3C375%3A%3AAID-PROT1%3E3.0.CO%3B2-2">10.1002/(SICI)1097-0134(19990601)35:4<375::AID-PROT1>3.0.CO;2-2</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10382665">10382665</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proteins&rft.atitle=Structure+of+the+integral+membrane+domain+of+the+GLP1+receptor&rft.volume=35&rft.issue=4&rft.pages=375-86&rft.date=1999-06&rft_id=info%3Adoi%2F10.1002%2F%28SICI%291097-0134%2819990601%2935%3A4%3C375%3A%3AAID-PROT1%3E3.0.CO%3B2-2&rft_id=info%3Apmid%2F10382665&rft.aulast=Frimurer&rft.aufirst=TM&rft.au=Bywater%2C+RP&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252F%2528SICI%25291097-0134%252819990601%252935%253A4%253C375%253A%253AAID-PROT1%253E3.0.CO%253B2-2&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHuypensLingPipeleersSchuit2000" class="citation journal cs1">Huypens P, Ling Z, Pipeleers D, Schuit F (August 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs001250051484">"Glucagon receptors on human islet cells contribute to glucose competence of insulin release"</a>. <i>Diabetologia</i>. <b>43</b> (8): 1012–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs001250051484">10.1007/s001250051484</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10990079">10990079</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diabetologia&rft.atitle=Glucagon+receptors+on+human+islet+cells+contribute+to+glucose+competence+of+insulin+release&rft.volume=43&rft.issue=8&rft.pages=1012-9&rft.date=2000-08&rft_id=info%3Adoi%2F10.1007%2Fs001250051484&rft_id=info%3Apmid%2F10990079&rft.aulast=Huypens&rft.aufirst=P&rft.au=Ling%2C+Z&rft.au=Pipeleers%2C+D&rft.au=Schuit%2C+F&rft_id=https%3A%2F%2Fdoi.org%2F10.1007%252Fs001250051484&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHartleyTempleBrasch2000" class="citation journal cs1">Hartley JL, Temple GF, Brasch MA (November 2000). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948">"DNA cloning using in vitro site-specific recombination"</a>. <i>Genome Research</i>. <b>10</b> (11): 1788–95. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1101%2Fgr.143000">10.1101/gr.143000</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC310948">310948</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11076863">11076863</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=DNA+cloning+using+in+vitro+site-specific+recombination&rft.volume=10&rft.issue=11&rft.pages=1788-95&rft.date=2000-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC310948%23id-name%3DPMC&rft_id=info%3Apmid%2F11076863&rft_id=info%3Adoi%2F10.1101%2Fgr.143000&rft.aulast=Hartley&rft.aufirst=JL&rft.au=Temple%2C+GF&rft.au=Brasch%2C+MA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC310948&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFXiaoJengWheeler2000" class="citation journal cs1">Xiao Q, Jeng W, Wheeler MB (December 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1677%2Fjme.0.0250321">"Characterization of glucagon-like peptide-1 receptor-binding determinants"</a>. <i>Journal of Molecular Endocrinology</i>. <b>25</b> (3): 321–35. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1677%2Fjme.0.0250321">10.1677/jme.0.0250321</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11116211">11116211</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Endocrinology&rft.atitle=Characterization+of+glucagon-like+peptide-1+receptor-binding+determinants&rft.volume=25&rft.issue=3&rft.pages=321-35&rft.date=2000-12&rft_id=info%3Adoi%2F10.1677%2Fjme.0.0250321&rft_id=info%3Apmid%2F11116211&rft.aulast=Xiao&rft.aufirst=Q&rft.au=Jeng%2C+W&rft.au=Wheeler%2C+MB&rft_id=https%3A%2F%2Fdoi.org%2F10.1677%252Fjme.0.0250321&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBazarsurenGrauschopfWoznyReusch2002" class="citation journal cs1">Bazarsuren A, Grauschopf U, Wozny M, Reusch D, Hoffmann E, Schaefer W, et al. (May 2002). "In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor". <i>Biophysical Chemistry</i>. <b>96</b> (2–3): 305–18. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS0301-4622%2802%2900023-6">10.1016/S0301-4622(02)00023-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12034449">12034449</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biophysical+Chemistry&rft.atitle=In+vitro+folding%2C+functional+characterization%2C+and+disulfide+pattern+of+the+extracellular+domain+of+human+GLP-1+receptor&rft.volume=96&rft.issue=2%E2%80%933&rft.pages=305-18&rft.date=2002-05&rft_id=info%3Adoi%2F10.1016%2FS0301-4622%2802%2900023-6&rft_id=info%3Apmid%2F12034449&rft.aulast=Bazarsuren&rft.aufirst=A&rft.au=Grauschopf%2C+U&rft.au=Wozny%2C+M&rft.au=Reusch%2C+D&rft.au=Hoffmann%2C+E&rft.au=Schaefer%2C+W&rft.au=Panzner%2C+S&rft.au=Rudolph%2C+R&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFTokuyamaMatsuiEgashiraNozaki2004" class="citation journal cs1">Tokuyama Y, Matsui K, Egashira T, Nozaki O, Ishizuka T, Kanatsuka A (October 2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.diabres.2004.02.004">"Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population"</a>. <i>Diabetes Research and Clinical Practice</i>. <b>66</b> (1): 63–9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.diabres.2004.02.004">10.1016/j.diabres.2004.02.004</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15364163">15364163</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diabetes+Research+and+Clinical+Practice&rft.atitle=Five+missense+mutations+in+glucagon-like+peptide+1+receptor+gene+in+Japanese+population&rft.volume=66&rft.issue=1&rft.pages=63-9&rft.date=2004-10&rft_id=info%3Adoi%2F10.1016%2Fj.diabres.2004.02.004&rft_id=info%3Apmid%2F15364163&rft.aulast=Tokuyama&rft.aufirst=Y&rft.au=Matsui%2C+K&rft.au=Egashira%2C+T&rft.au=Nozaki%2C+O&rft.au=Ishizuka%2C+T&rft.au=Kanatsuka%2C+A&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.diabres.2004.02.004&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFJorgensenMartiniSchwartzElling2005" class="citation journal cs1">Jorgensen R, Martini L, Schwartz TW, Elling CE (March 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fme.2004-0312">"Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype"</a>. <i>Molecular Endocrinology</i>. <b>19</b> (3): 812–23. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1210%2Fme.2004-0312">10.1210/me.2004-0312</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15528268">15528268</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Endocrinology&rft.atitle=Characterization+of+glucagon-like+peptide-1+receptor+beta-arrestin+2+interaction%3A+a+high-affinity+receptor+phenotype&rft.volume=19&rft.issue=3&rft.pages=812-23&rft.date=2005-03&rft_id=info%3Adoi%2F10.1210%2Fme.2004-0312&rft_id=info%3Apmid%2F15528268&rft.aulast=Jorgensen&rft.aufirst=R&rft.au=Martini%2C+L&rft.au=Schwartz%2C+TW&rft.au=Elling%2C+CE&rft_id=https%3A%2F%2Fdoi.org%2F10.1210%252Fme.2004-0312&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMahonShimada2005" class="citation journal cs1">Mahon MJ, Shimada M (January 2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors". <i>FEBS Letters</i>. <b>579</b> (3): 803–7. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2005FEBSL.579..803M">2005FEBSL.579..803M</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.febslet.2004.12.056">10.1016/j.febslet.2004.12.056</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15670850">15670850</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:6471940">6471940</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FEBS+Letters&rft.atitle=Calmodulin+interacts+with+the+cytoplasmic+tails+of+the+parathyroid+hormone+1+receptor+and+a+sub-set+of+class+b+G-protein+coupled+receptors&rft.volume=579&rft.issue=3&rft.pages=803-7&rft.date=2005-01&rft_id=info%3Adoi%2F10.1016%2Fj.febslet.2004.12.056&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A6471940%23id-name%3DS2CID&rft_id=info%3Apmid%2F15670850&rft_id=info%3Abibcode%2F2005FEBSL.579..803M&rft.aulast=Mahon&rft.aufirst=MJ&rft.au=Shimada%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGraafDonnellyWoottenLau2016" class="citation journal cs1">Graaf C, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, et al. (October 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050443">"Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes"</a>. <i>Pharmacological Reviews</i>. <b>68</b> (4): 954–1013. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1124%2Fpr.115.011395">10.1124/pr.115.011395</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050443">5050443</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27630114">27630114</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacological+Reviews&rft.atitle=Glucagon-Like+Peptide-1+and+Its+Class+B+G+Protein-Coupled+Receptors%3A+A+Long+March+to+Therapeutic+Successes&rft.volume=68&rft.issue=4&rft.pages=954-1013&rft.date=2016-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5050443%23id-name%3DPMC&rft_id=info%3Apmid%2F27630114&rft_id=info%3Adoi%2F10.1124%2Fpr.115.011395&rft.aulast=Graaf&rft.aufirst=C&rft.au=Donnelly%2C+D&rft.au=Wootten%2C+D&rft.au=Lau%2C+J&rft.au=Sexton%2C+PM&rft.au=Miller%2C+LJ&rft.au=Ahn%2C+JM&rft.au=Liao%2C+J&rft.au=Fletcher%2C+MM&rft.au=Yang%2C+D&rft.au=Brown%2C+AJ&rft.au=Zhou%2C+C&rft.au=Deng%2C+J&rft.au=Wang%2C+MW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5050443&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSongYangWangde_Graaf2017" class="citation journal cs1">Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, et al. (June 2017). "Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators". <i>Nature</i>. <b>546</b> (7657): 312–315. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2017Natur.546..312S">2017Natur.546..312S</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature22378">10.1038/nature22378</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28514449">28514449</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:2141649">2141649</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Human+GLP-1+receptor+transmembrane+domain+structure+in+complex+with+allosteric+modulators&rft.volume=546&rft.issue=7657&rft.pages=312-315&rft.date=2017-06&rft_id=info%3Adoi%2F10.1038%2Fnature22378&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A2141649%23id-name%3DS2CID&rft_id=info%3Apmid%2F28514449&rft_id=info%3Abibcode%2F2017Natur.546..312S&rft.aulast=Song&rft.aufirst=G&rft.au=Yang%2C+D&rft.au=Wang%2C+Y&rft.au=de+Graaf%2C+C&rft.au=Zhou%2C+Q&rft.au=Jiang%2C+S&rft.au=Liu%2C+K&rft.au=Cai%2C+X&rft.au=Dai%2C+A&rft.au=Lin%2C+G&rft.au=Liu%2C+D&rft.au=Wu%2C+F&rft.au=Wu%2C+Y&rft.au=Zhao%2C+S&rft.au=Ye%2C+L&rft.au=Han%2C+GW&rft.au=Lau%2C+J&rft.au=Wu%2C+B&rft.au=Hanson%2C+MA&rft.au=Liu%2C+ZJ&rft.au=Wang%2C+MW&rft.au=Stevens%2C+RC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBrunton2014" class="citation journal cs1">Brunton S (May 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238422">"GLP-1 receptor agonists vs. DPP-4 inhibitors for type 2 diabetes: is one approach more successful or preferable than the other?"</a>. <i>International Journal of Clinical Practice</i>. <b>68</b> (5): 557–567. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fijcp.12361">10.1111/ijcp.12361</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238422">4238422</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24499291">24499291</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Clinical+Practice&rft.atitle=GLP-1+receptor+agonists+vs.+DPP-4+inhibitors+for+type+2+diabetes%3A+is+one+approach+more+successful+or+preferable+than+the+other%3F&rft.volume=68&rft.issue=5&rft.pages=557-567&rft.date=2014-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4238422%23id-name%3DPMC&rft_id=info%3Apmid%2F24499291&rft_id=info%3Adoi%2F10.1111%2Fijcp.12361&rft.aulast=Brunton&rft.aufirst=S&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4238422&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDonnelly2012" class="citation journal cs1">Donnelly D (May 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415635">"The structure and function of the glucagon-like peptide-1 receptor and its ligands"</a>. <i>British Journal of Pharmacology</i>. <b>166</b> (1): 27–41. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1476-5381.2011.01687.x">10.1111/j.1476-5381.2011.01687.x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415635">3415635</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21950636">21950636</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=British+Journal+of+Pharmacology&rft.atitle=The+structure+and+function+of+the+glucagon-like+peptide-1+receptor+and+its+ligands&rft.volume=166&rft.issue=1&rft.pages=27-41&rft.date=2012-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3415635%23id-name%3DPMC&rft_id=info%3Apmid%2F21950636&rft_id=info%3Adoi%2F10.1111%2Fj.1476-5381.2011.01687.x&rft.aulast=Donnelly&rft.aufirst=D&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3415635&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFChristouKatsikiBlundellFruhbeck2019" class="citation journal cs1">Christou GA, Katsiki N, Blundell J, Fruhbeck G, Kiortsis DN (June 2019). "Semaglutide as a promising antiobesity drug". <i>Obesity Reviews</i>. <b>20</b> (6): 805–815. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fobr.12839">10.1111/obr.12839</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30768766">30768766</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:73422503">73422503</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Obesity+Reviews&rft.atitle=Semaglutide+as+a+promising+antiobesity+drug&rft.volume=20&rft.issue=6&rft.pages=805-815&rft.date=2019-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A73422503%23id-name%3DS2CID&rft_id=info%3Apmid%2F30768766&rft_id=info%3Adoi%2F10.1111%2Fobr.12839&rft.aulast=Christou&rft.aufirst=GA&rft.au=Katsiki%2C+N&rft.au=Blundell%2C+J&rft.au=Fruhbeck%2C+G&rft.au=Kiortsis%2C+DN&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Glucagon-like_peptide-1_receptor&action=edit&section=11" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20160303203617/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2288">"Glucagon Receptor Family: GLP-1"</a>. <i>IUPHAR Database of Receptors and Ion Channels</i>. International Union of Basic and Clinical Pharmacology. Archived from <a rel="nofollow" class="external text" href="http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2288">the original</a> on 2016-03-03<span class="reference-accessdate">. Retrieved <span class="nowrap">2007-10-25</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=IUPHAR+Database+of+Receptors+and+Ion+Channels&rft.atitle=Glucagon+Receptor+Family%3A+GLP-1&rft_id=http%3A%2F%2Fwww.iuphar-db.org%2FGPCR%2FReceptorDisplayForward%3FreceptorID%3D2288&rfr_id=info%3Asid%2Fen.wikipedia.org%3AGlucagon-like+peptide-1+receptor" class="Z3988"></span></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=glucagon-like+peptide+receptor">glucagon-like+peptide+receptor</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P43220">P43220</a></i> (Glucagon-like peptide 1 receptor) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist 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href="/wiki/Special:EditPage/Template:G_protein-coupled_receptors" title="Special:EditPage/Template:G protein-coupled receptors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Cell_surface_receptor:_G_protein-coupled_receptors" style="font-size:114%;margin:0 4em"><a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">Cell surface receptor</a>: <a href="/wiki/G_protein-coupled_receptor" title="G protein-coupled receptor">G protein-coupled receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_A:_Rhodopsin-like" style="font-size:114%;margin:0 4em"><a href="/wiki/Rhodopsin-like_receptors" title="Rhodopsin-like receptors">Class A</a>: <a href="/wiki/Rhodopsin" title="Rhodopsin">Rhodopsin</a>-like</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Neurotransmitter_receptor" title="Neurotransmitter receptor">Neurotransmitter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Adrenergic_receptor" title="Adrenergic receptor">Adrenergic</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-1_adrenergic_receptor" title="Alpha-1 adrenergic receptor">α1</a> (<a href="/wiki/Alpha-1A_adrenergic_receptor" title="Alpha-1A adrenergic receptor">A</a></li> <li><a href="/wiki/Alpha-1B_adrenergic_receptor" title="Alpha-1B adrenergic receptor">B</a></li> <li><a href="/wiki/Alpha-1D_adrenergic_receptor" title="Alpha-1D adrenergic receptor">D</a>)</li> <li><a href="/wiki/Alpha-2_adrenergic_receptor" title="Alpha-2 adrenergic receptor">α2</a> (<a href="/wiki/Alpha-2A_adrenergic_receptor" title="Alpha-2A adrenergic receptor">A</a></li> <li><a href="/wiki/Alpha-2B_adrenergic_receptor" title="Alpha-2B adrenergic receptor">B</a></li> <li><a href="/wiki/Alpha-2C_adrenergic_receptor" title="Alpha-2C adrenergic receptor">C</a>)</li> <li><a href="/wiki/Beta-1_adrenergic_receptor" title="Beta-1 adrenergic receptor">β1</a></li> <li><a href="/wiki/Beta-2_adrenergic_receptor" title="Beta-2 adrenergic receptor">β2</a></li> <li><a href="/wiki/Beta-3_adrenergic_receptor" title="Beta-3 adrenergic receptor">β3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Purinergic_receptor" title="Purinergic receptor">Purinergic</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenosine_receptor" title="Adenosine receptor">Adenosine</a> (<a href="/wiki/Adenosine_A1_receptor" title="Adenosine A1 receptor">A1</a></li> <li><a href="/wiki/Adenosine_A2A_receptor" title="Adenosine A2A receptor">A2A</a></li> <li><a href="/wiki/Adenosine_A2B_receptor" title="Adenosine A2B receptor">A2B</a></li> <li><a href="/wiki/Adenosine_A3_receptor" title="Adenosine A3 receptor">A3</a>)</li> <li><a href="/wiki/P2Y_receptor" title="P2Y receptor">P2Y</a> (<a href="/wiki/P2RY1" title="P2RY1">1</a></li> <li><a href="/wiki/P2RY2" title="P2RY2">2</a></li> <li><a href="/wiki/P2RY4" title="P2RY4">4</a></li> <li><a href="/wiki/LPAR6" title="LPAR6">5</a></li> <li><a href="/wiki/P2RY6" title="P2RY6">6</a></li> <li><a href="/wiki/P2RY8" title="P2RY8">8</a></li> <li><a href="/wiki/GPR23" class="mw-redirect" title="GPR23">9</a></li> <li><a href="/wiki/P2RY10" title="P2RY10">10</a></li> <li><a href="/wiki/P2RY11" title="P2RY11">11</a></li> <li><a href="/wiki/P2Y12" title="P2Y12">12</a></li> <li><a href="/wiki/P2RY13" title="P2RY13">13</a></li> <li><a href="/wiki/P2RY14" title="P2RY14">14</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/5-HT_receptor" title="5-HT receptor">Serotonin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>(all but <a href="/wiki/5-HT3_receptor" title="5-HT3 receptor">5-HT3</a>)</i> <a href="/wiki/5-HT1_receptor" title="5-HT1 receptor">5-HT1</a> (<a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">A</a></li> <li><a href="/wiki/5-HT1B_receptor" title="5-HT1B receptor">B</a></li> <li><a href="/wiki/5-HT1D_receptor" title="5-HT1D receptor">D</a></li> <li><a href="/wiki/5-HT1E_receptor" title="5-HT1E receptor">E</a></li> <li><a href="/wiki/5-HT1F_receptor" title="5-HT1F receptor">F</a>)</li> <li><a href="/wiki/5-HT2_receptor" title="5-HT2 receptor">5-HT2</a> (<a href="/wiki/5-HT2A_receptor" title="5-HT2A receptor">A</a></li> <li><a href="/wiki/5-HT2B_receptor" title="5-HT2B receptor">B</a></li> <li><a href="/wiki/5-HT2C_receptor" title="5-HT2C receptor">C</a>)</li> <li><i>5-HT</i> (<a href="/wiki/5-HT4_receptor" title="5-HT4 receptor">4</a></li> <li><a href="/wiki/5-HT5A_receptor" title="5-HT5A receptor">5A</a></li> <li><a href="/wiki/5-HT6_receptor" title="5-HT6 receptor">6</a></li> <li><a href="/wiki/5-HT7_receptor" title="5-HT7 receptor">7</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Muscarinic_acetylcholine_receptor" title="Muscarinic acetylcholine receptor">Acetylcholine</a> (<a href="/wiki/Muscarinic_acetylcholine_receptor_M1" title="Muscarinic acetylcholine receptor M1">M1</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M2" title="Muscarinic acetylcholine receptor M2">M2</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M3" title="Muscarinic acetylcholine receptor M3">M3</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M4" title="Muscarinic acetylcholine receptor M4">M4</a></li> <li><a href="/wiki/Muscarinic_acetylcholine_receptor_M5" title="Muscarinic acetylcholine receptor M5">M5</a>)</li> <li><a href="/wiki/Dopamine_receptor" title="Dopamine receptor">Dopamine</a> <ul><li><a href="/wiki/Dopamine_receptor_D1" title="Dopamine receptor D1">D1</a></li> <li><a href="/wiki/Dopamine_receptor_D2" title="Dopamine receptor D2">D2</a></li> <li><a href="/wiki/Dopamine_receptor_D3" title="Dopamine receptor D3">D3</a></li> <li><a href="/wiki/Dopamine_receptor_D4" title="Dopamine receptor D4">D4</a></li> <li><a href="/wiki/Dopamine_receptor_D5" title="Dopamine receptor D5">D5</a></li></ul></li> <li><a href="/wiki/GHB_receptor" title="GHB receptor">GHB receptor</a></li> <li><a href="/wiki/Histamine_receptor" title="Histamine receptor">Histamine</a> <ul><li><a href="/wiki/Histamine_H1_receptor" title="Histamine H1 receptor">H1</a></li> <li><a href="/wiki/Histamine_H2_receptor" title="Histamine H2 receptor">H2</a></li> <li><a href="/wiki/Histamine_H3_receptor" title="Histamine H3 receptor">H3</a></li> <li><a href="/wiki/Histamine_H4_receptor" title="Histamine H4 receptor">H4</a></li></ul></li> <li><a href="/wiki/Melatonin_receptor" title="Melatonin receptor">Melatonin</a> (<a href="/wiki/Melatonin_receptor_1A" title="Melatonin receptor 1A">1A</a></li> <li><a href="/wiki/Melatonin_receptor_1B" title="Melatonin receptor 1B">1B</a></li> <li><a href="/wiki/Melatonin_receptor_1C" title="Melatonin receptor 1C">1C</a>)</li> <li><a href="/wiki/Trace_amine-associated_receptor" title="Trace amine-associated receptor">TAAR</a> (<a href="/wiki/TAAR1" title="TAAR1">1</a></li> <li><a href="/wiki/TAAR2" title="TAAR2">2</a></li> <li><a href="/wiki/TAAR5" title="TAAR5">5</a></li> <li><a href="/wiki/TAAR6" title="TAAR6">6</a></li> <li><a href="/wiki/TAAR8" title="TAAR8">8</a></li> <li><a href="/wiki/TAAR9" title="TAAR9">9</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Metabolites and<br />signaling molecules</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Eicosanoid_receptor" title="Eicosanoid receptor">Eicosanoid</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>CysLT</i> (<a href="/wiki/Cysteinyl_leukotriene_receptor_1" title="Cysteinyl leukotriene receptor 1">1</a></li> <li><a href="/wiki/Cysteinyl_leukotriene_receptor_2" title="Cysteinyl leukotriene receptor 2">2</a>)</li> <li><a href="/wiki/Leukotriene_B4" title="Leukotriene B4">LTB4</a> <ul><li><a href="/wiki/Leukotriene_B4_receptor" title="Leukotriene B4 receptor">1</a></li> <li><a href="/wiki/Leukotriene_B4_receptor_2" title="Leukotriene B4 receptor 2">2</a></li></ul></li> <li><a href="/wiki/Formyl_peptide_receptor_2" title="Formyl peptide receptor 2"> FPRL1</a></li> <li><a href="/wiki/Oxoeicosanoid_receptor_1" title="Oxoeicosanoid receptor 1">OXE</a></li> <li><a href="/wiki/Prostaglandin_receptor" title="Prostaglandin receptor">Prostaglandin</a> <ul><li><i>DP</i> (<a href="/wiki/Prostaglandin_D2_receptor" title="Prostaglandin D2 receptor">1</a></li> <li><a href="/wiki/GPR44" class="mw-redirect" title="GPR44">2</a>), <i>EP</i> (<a href="/wiki/EP1_receptor" class="mw-redirect" title="EP1 receptor">1</a></li> <li><a href="/wiki/Prostaglandin_E2_receptor" title="Prostaglandin E2 receptor">2</a></li> <li><a href="/wiki/Prostaglandin_E_receptor_3" class="mw-redirect" title="Prostaglandin E receptor 3">3</a></li> <li><a href="/wiki/EP4_receptor" class="mw-redirect" title="EP4 receptor">4</a>), <a href="/wiki/Prostaglandin_F_receptor" title="Prostaglandin F receptor">FP</a></li></ul></li> <li><a href="/wiki/Prostacyclin_receptor" title="Prostacyclin receptor">Prostacyclin</a></li> <li><a href="/wiki/Thromboxane_receptor" title="Thromboxane receptor">Thromboxane</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/G_protein-coupled_bile_acid_receptor" title="G protein-coupled bile acid receptor">Bile acid</a></li> <li><a href="/wiki/Cannabinoid_receptor" title="Cannabinoid receptor">Cannabinoid</a> (<a href="/wiki/Cannabinoid_receptor_type_1" class="mw-redirect" title="Cannabinoid receptor type 1">CB1</a></li> <li><a href="/wiki/Cannabinoid_receptor_type_2" class="mw-redirect" title="Cannabinoid receptor type 2">CB2</a>, <i>GPR</i> (<a href="/wiki/GPR18" class="mw-redirect" title="GPR18">18</a></li> <li><a href="/wiki/GPR55" title="GPR55">55</a></li> <li><a href="/wiki/GPR119" title="GPR119">119</a>))</li> <li><a href="/wiki/GPR183" title="GPR183">EBI2</a></li> <li><a href="/wiki/GPER" title="GPER">Estrogen</a></li> <li><a href="/wiki/Free_fatty_acid_receptor" title="Free fatty acid receptor">Free fatty acid</a> (<a href="/wiki/Free_fatty_acid_receptor_1" title="Free fatty acid receptor 1">1</a></li> <li><a href="/wiki/Free_fatty_acid_receptor_2" title="Free fatty acid receptor 2">2</a></li> <li><a href="/wiki/Free_fatty_acid_receptor_3" title="Free fatty acid receptor 3">3</a></li> <li><a href="/wiki/GPR42" title="GPR42">4</a>)</li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor" title="Hydroxycarboxylic acid receptor">Hydroxycarboxylic acids</a> <ul><li><a href="/wiki/Hydroxycarboxylic_acid_receptor_1" title="Hydroxycarboxylic acid receptor 1">1</a></li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor_2" title="Hydroxycarboxylic acid receptor 2">2</a></li> <li><a href="/wiki/Hydroxycarboxylic_acid_receptor_3" title="Hydroxycarboxylic acid receptor 3">3</a></li></ul></li> <li><a href="/wiki/Lysophosphatidic_acid" title="Lysophosphatidic acid">Lysophosphatidic acid</a> (<a href="/wiki/LPAR1" title="LPAR1">1</a></li> <li><a href="/wiki/LPAR2" title="LPAR2">2</a></li> <li><a href="/wiki/LPAR3" title="LPAR3">3</a></li> <li><a href="/wiki/LPAR4" title="LPAR4">4</a></li> <li><a href="/wiki/LPAR5" title="LPAR5">5</a></li> <li><a href="/wiki/LPAR6" title="LPAR6">6</a>)</li> <li><a href="/wiki/Lysophospholipid_receptor" title="Lysophospholipid receptor">Lysophospholipid</a> (<a href="/wiki/S1PR1" title="S1PR1">1</a></li> <li><a href="/wiki/LPAR1" title="LPAR1">2</a></li> <li><a href="/wiki/S1PR3" title="S1PR3">3</a></li> <li><a href="/wiki/LPAR2" title="LPAR2">4</a></li> <li><a href="/wiki/S1PR2" title="S1PR2">5</a></li> <li><a href="/wiki/S1PR4" title="S1PR4">6</a></li> <li><a href="/wiki/LPAR3" title="LPAR3">7</a></li> <li><a href="/wiki/S1PR5" title="S1PR5">8</a>)</li> <li><a href="/wiki/OXGR1" title="OXGR1">Oxoglutarate</a></li> <li><a href="/wiki/Platelet-activating_factor_receptor" title="Platelet-activating factor receptor">PAF</a></li> <li><a href="/wiki/Sphingosine-1-phosphate" title="Sphingosine-1-phosphate">Sphingosine-1-phosphate</a> (<a href="/wiki/S1PR1" title="S1PR1">1</a></li> <li><a href="/wiki/S1PR2" title="S1PR2">2</a></li> <li><a href="/wiki/S1PR3" title="S1PR3">3</a></li> <li><a href="/wiki/S1PR4" title="S1PR4">4</a></li> <li><a href="/wiki/S1PR5" title="S1PR5">5</a>)</li> <li><a href="/wiki/SUCNR1" title="SUCNR1">Succinate</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Peptide</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/GPCR_neuropeptide_receptor" title="GPCR neuropeptide receptor">Neuropeptide</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neuropeptide_B/W_receptor" title="Neuropeptide B/W receptor">B/W</a> (<a href="/wiki/Neuropeptides_B/W_receptor_1" title="Neuropeptides B/W receptor 1">1</a></li> <li><a href="/wiki/Neuropeptides_B/W_receptor_2" title="Neuropeptides B/W receptor 2">2</a>)</li> <li><a href="/wiki/Neuropeptide_FF_receptor" title="Neuropeptide FF receptor">FF</a> (<a href="/wiki/Neuropeptide_FF_receptor_1" title="Neuropeptide FF receptor 1">1</a></li> <li><a href="/wiki/Neuropeptide_FF_receptor_2" title="Neuropeptide FF receptor 2">2</a>)</li> <li><a href="/wiki/Neuropeptide_S_receptor" title="Neuropeptide S receptor">S</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor" title="Neuropeptide Y receptor">Y</a> (<a href="/wiki/Neuropeptide_Y_receptor_Y1" title="Neuropeptide Y receptor Y1">1</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor_Y2" title="Neuropeptide Y receptor Y2">2</a></li> <li><a href="/wiki/Pancreatic_polypeptide_receptor_1" title="Pancreatic polypeptide receptor 1">4</a></li> <li><a href="/wiki/Neuropeptide_Y_receptor_Y5" title="Neuropeptide Y receptor Y5">5</a>)</li> <li><i>Neuromedin</i> (<a href="/wiki/Neuromedin_B_receptor" title="Neuromedin B receptor">B</a></li> <li><a href="/wiki/Neuromedin_U_receptor" title="Neuromedin U receptor">U</a> (<a href="/wiki/Neuromedin_U_receptor_1" title="Neuromedin U receptor 1">1</a></li> <li><a href="/wiki/Neuromedin_U_receptor_2" title="Neuromedin U receptor 2">2</a>))</li> <li><a href="/wiki/Neurotensin_receptor" title="Neurotensin receptor">Neurotensin</a> (<a href="/wiki/Neurotensin_receptor_1" title="Neurotensin receptor 1">1</a></li> <li><a href="/wiki/Neurotensin_receptor_2" title="Neurotensin receptor 2">2</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anaphylatoxin_receptors" title="Anaphylatoxin receptors">Anaphylatoxin</a> (<a href="/wiki/C3a_receptor" title="C3a receptor">C3a</a></li> <li>C5a (<a href="/wiki/C5a_receptor" title="C5a receptor">1</a></li> <li><a href="/wiki/C5AR2" title="C5AR2">2</a>))</li> <li><a href="/wiki/Angiotensin_receptor" class="mw-redirect" title="Angiotensin receptor">Angiotensin</a> (<a href="/wiki/Angiotensin_II_receptor_type_1" title="Angiotensin II receptor type 1">1</a></li> <li><a href="/wiki/Angiotensin_II_receptor_type_2" title="Angiotensin II receptor type 2">2</a>)</li> <li><a href="/wiki/Apelin_receptor" title="Apelin receptor">Apelin</a></li> <li><a href="/wiki/Bombesin_receptor" title="Bombesin receptor">Bombesin</a> <ul><li><a href="/wiki/Bombesin-like_receptor_3" title="Bombesin-like receptor 3">BRS3</a></li> <li><a href="/wiki/Gastrin-releasing_peptide_receptor" title="Gastrin-releasing peptide receptor">GRPR</a></li> <li><a href="/wiki/Neuromedin_B_receptor" title="Neuromedin B receptor">NMBR</a>)</li> <li><a href="/wiki/Bradykinin_receptor" title="Bradykinin receptor">Bradykinin</a> (<a href="/wiki/Bradykinin_receptor_B1" title="Bradykinin receptor B1">B1</a></li> <li><a href="/wiki/Bradykinin_receptor_B2" title="Bradykinin receptor B2">B2</a>)</li></ul></li> <li><a href="/wiki/Chemokine_receptor" title="Chemokine receptor">Chemokine</a></li> <li><a href="/wiki/Cholecystokinin_receptor" title="Cholecystokinin receptor">Cholecystokinin</a> (<a href="/wiki/Cholecystokinin_A_receptor" title="Cholecystokinin A receptor">A</a></li> <li><a href="/wiki/Cholecystokinin_B_receptor" title="Cholecystokinin B receptor">B</a>)</li> <li><a href="/wiki/Endothelin_receptor" title="Endothelin receptor">Endothelin</a> <ul><li><a href="/wiki/Endothelin_A_receptor" title="Endothelin A receptor">A</a></li> <li><a href="/wiki/Endothelin_B_receptor" class="mw-redirect" title="Endothelin B receptor">B</a></li></ul></li> <li><a href="/wiki/Formyl_peptide_receptor" title="Formyl peptide receptor">Formyl peptide</a> (<a href="/wiki/Formyl_peptide_receptor_1" title="Formyl peptide receptor 1">1</a></li> <li><a href="/wiki/Formyl_peptide_receptor_2" title="Formyl peptide receptor 2">2</a></li> <li><a href="/wiki/Formyl_peptide_receptor_3" title="Formyl peptide receptor 3">3</a>)</li> <li><a href="/wiki/Follicle-stimulating_hormone_receptor" title="Follicle-stimulating hormone receptor">FSH</a></li> <li><a href="/wiki/Galanin_receptor" title="Galanin receptor">Galanin</a> (<a href="/wiki/Galanin_receptor_1" title="Galanin receptor 1">1</a></li> <li><a href="/wiki/Galanin_receptor_2" title="Galanin receptor 2">2</a></li> <li><a href="/wiki/Galanin_receptor_3" title="Galanin receptor 3">3</a>)</li> <li><a href="/wiki/Gonadotropin-releasing_hormone_receptor" title="Gonadotropin-releasing hormone receptor">Gonadotropin-releasing hormone</a> (<a href="/wiki/GNRHR" title="GNRHR">1</a></li> <li><a href="/wiki/GNRHR2" title="GNRHR2">2</a>)</li> <li><a href="/wiki/Growth_hormone_secretagogue_receptor" title="Growth hormone secretagogue receptor">Ghrelin</a></li> <li><a href="/wiki/KiSS1-derived_peptide_receptor" title="KiSS1-derived peptide receptor"> Kisspeptin</a></li> <li><a href="/wiki/Luteinizing_hormone/choriogonadotropin_receptor" title="Luteinizing hormone/choriogonadotropin receptor">Luteinizing hormone/choriogonadotropin</a></li> <li><a href="/wiki/MAS1_oncogene" title="MAS1 oncogene">MAS</a> (<a href="/wiki/MAS1" title="MAS1">1</a></li> <li><a href="/wiki/MAS1L" title="MAS1L">1L</a></li> <li><a href="/wiki/MRGPRD" title="MRGPRD">D</a></li> <li><a href="/wiki/MRGPRE" title="MRGPRE">E</a></li> <li><a href="/wiki/MRGPRF" title="MRGPRF">F</a></li> <li><a href="/wiki/MRGPRG" title="MRGPRG">G</a></li> <li><a href="/wiki/MRGPRX1" title="MRGPRX1">X1</a></li> <li><a href="/wiki/MRGPRX2" title="MRGPRX2">X2</a></li> <li><a href="/wiki/MRGPRX3" title="MRGPRX3">X3</a></li> <li><a href="/wiki/MRGPRX4" title="MRGPRX4">X4</a>)</li> <li><a href="/wiki/Melanocortin_receptor" title="Melanocortin receptor">Melanocortin</a> (<a href="/wiki/Melanocortin_1_receptor" title="Melanocortin 1 receptor">1</a></li> <li><a href="/wiki/ACTH_receptor" title="ACTH receptor">2</a></li> <li><a href="/wiki/Melanocortin_3_receptor" title="Melanocortin 3 receptor">3</a></li> <li><a href="/wiki/Melanocortin_4_receptor" title="Melanocortin 4 receptor">4</a></li> <li><a href="/wiki/Melanocortin_5_receptor" title="Melanocortin 5 receptor">5</a>)</li> <li><a href="/wiki/Melanin-concentrating_hormone_receptor" title="Melanin-concentrating hormone receptor">MCHR</a> (<a href="/wiki/Melanin-concentrating_hormone_receptor_1" title="Melanin-concentrating hormone receptor 1">1</a></li> <li><a href="/wiki/Melanin-concentrating_hormone_receptor_2" title="Melanin-concentrating hormone receptor 2">2</a>)</li> <li><a href="/wiki/Motilin_receptor" title="Motilin receptor">Motilin</a></li> <li><a href="/wiki/Opioid_receptor" title="Opioid receptor">Opioid</a> (<a href="/wiki/%CE%94-opioid_receptor" title="Δ-opioid receptor">Delta</a></li> <li><a href="/wiki/%CE%9A-opioid_receptor" title="Κ-opioid receptor">Kappa</a></li> <li><a href="/wiki/%CE%9C-opioid_receptor" title="Μ-opioid receptor">Mu</a></li> <li><a href="/wiki/Nociceptin_receptor" title="Nociceptin receptor">Nociceptin</a> & <a href="/wiki/OGFr" title="OGFr">Zeta</a>, but not <a href="/wiki/Sigma_receptor" title="Sigma receptor">Sigma</a>)</li> <li><a href="/wiki/Orexin_receptor" title="Orexin receptor">Orexin</a> (<a href="/wiki/Hypocretin_(orexin)_receptor_1" title="Hypocretin (orexin) receptor 1">1</a></li> <li><a href="/wiki/Hypocretin_(orexin)_receptor_2" title="Hypocretin (orexin) receptor 2">2</a>)</li> <li><a href="/wiki/Oxytocin_receptor" title="Oxytocin receptor">Oxytocin</a></li> <li><a href="/wiki/Prokineticin_receptor" title="Prokineticin receptor">Prokineticin</a> (<a href="/wiki/Prokineticin_receptor_1" title="Prokineticin receptor 1">1</a></li> <li><a href="/wiki/Prokineticin_receptor_2" title="Prokineticin receptor 2">2</a>)</li> <li><a href="/wiki/Prolactin-releasing_peptide_receptor" title="Prolactin-releasing peptide receptor">Prolactin-releasing peptide</a></li> <li><a href="/wiki/Relaxin_receptor" title="Relaxin receptor">Relaxin</a> (<a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_1" title="Relaxin/insulin-like family peptide receptor 1">1</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_2" title="Relaxin/insulin-like family peptide receptor 2">2</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_3" title="Relaxin/insulin-like family peptide receptor 3">3</a></li> <li><a href="/wiki/Relaxin/insulin-like_family_peptide_receptor_4" title="Relaxin/insulin-like family peptide receptor 4">4</a>)</li> <li><a href="/wiki/Somatostatin_receptor" title="Somatostatin receptor">Somatostatin</a> (<a href="/wiki/Somatostatin_receptor_1" title="Somatostatin receptor 1">1</a></li> <li><a href="/wiki/Somatostatin_receptor_2" title="Somatostatin receptor 2">2</a></li> <li><a href="/wiki/Somatostatin_receptor_3" title="Somatostatin receptor 3">3</a></li> <li><a href="/wiki/Somatostatin_receptor_4" title="Somatostatin receptor 4">4</a></li> <li><a href="/wiki/Somatostatin_receptor_5" title="Somatostatin receptor 5">5</a>)</li> <li><a href="/wiki/Tachykinin_receptor" title="Tachykinin receptor">Tachykinin</a> (<a href="/wiki/Tachykinin_receptor_1" title="Tachykinin receptor 1">1</a></li> <li><a href="/wiki/Tachykinin_receptor_2" title="Tachykinin receptor 2">2</a></li> <li><a href="/wiki/Tachykinin_receptor_3" title="Tachykinin receptor 3">3</a>)</li> <li><a href="/wiki/Thyrotropin_receptor" title="Thyrotropin receptor">Thyrotropin</a></li> <li><a href="/wiki/Thyrotropin-releasing_hormone_receptor" title="Thyrotropin-releasing hormone receptor">Thyrotropin-releasing hormone</a></li> <li><a href="/wiki/Urotensin-II_receptor" title="Urotensin-II receptor">Urotensin-II</a></li> <li><a href="/wiki/Vasopressin_receptor" title="Vasopressin receptor">Vasopressin</a> (<a href="/wiki/Arginine_vasopressin_receptor_1A" class="mw-redirect" title="Arginine vasopressin receptor 1A">1A</a></li> <li><a href="/wiki/Arginine_vasopressin_receptor_1B" class="mw-redirect" title="Arginine vasopressin receptor 1B">1B</a></li> <li><a href="/wiki/Arginine_vasopressin_receptor_2" class="mw-redirect" title="Arginine vasopressin receptor 2">2</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;">Miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Taste_receptor" title="Taste receptor">Taste</a>, bitter</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>TAS2R</i> <ul><li><a href="/wiki/TAS2R1" title="TAS2R1">1</a></li> <li><a href="/wiki/TAS2R3" title="TAS2R3">3</a></li> <li><a href="/wiki/TAS2R4" title="TAS2R4">4</a></li> <li><a href="/wiki/TAS2R5" title="TAS2R5">5</a></li> <li><a href="/wiki/TAS2R7" title="TAS2R7">7</a></li> <li><a href="/wiki/TAS2R8" title="TAS2R8">8</a></li> <li><a href="/wiki/TAS2R9" title="TAS2R9">9</a></li> <li><a href="/wiki/TAS2R10" title="TAS2R10">10</a></li> <li><a href="/wiki/TAS2R13" title="TAS2R13">13</a></li> <li><a href="/wiki/TAS2R14" title="TAS2R14">14</a></li> <li><a href="/wiki/TAS2R16" title="TAS2R16">16</a></li> <li><a href="/wiki/TAS2R19" title="TAS2R19">19</a></li> <li><a href="/wiki/TAS2R20" title="TAS2R20">20</a></li> <li><a href="/wiki/TAS2R30" title="TAS2R30">30</a></li> <li><a href="/wiki/TAS2R31" title="TAS2R31">31</a></li> <li><a href="/wiki/TAS2R38" title="TAS2R38">38</a></li> <li><a href="/wiki/TAS2R39" title="TAS2R39">39</a></li> <li><a href="/wiki/TAS2R40" title="TAS2R40">40</a></li> <li><a href="/wiki/TAS2R41" title="TAS2R41">41</a></li> <li><a href="/wiki/TAS2R42" title="TAS2R42">42</a></li> <li><a href="/wiki/TAS2R43" title="TAS2R43">43</a></li> <li><a href="/wiki/TAS2R45" title="TAS2R45">45</a></li> <li><a href="/wiki/TAS2R46" title="TAS2R46">46</a></li> <li><a href="/wiki/TAS2R50" title="TAS2R50">50</a></li> <li><a href="/wiki/TAS2R60" title="TAS2R60">60</a></li></ul></li> <li><a href="/wiki/Vomeronasal_receptor" title="Vomeronasal receptor">Vomeronasal receptor</a> type 1</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><a href="/wiki/Orphan_receptor" title="Orphan receptor">Orphan</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>GPR</i> (<a href="/wiki/GPR1" title="GPR1">1</a></li> <li><a href="/wiki/GPR3" title="GPR3">3</a></li> <li><a href="/wiki/GPR4" title="GPR4">4</a></li> <li><a href="/wiki/GPR6" title="GPR6">6</a></li> <li><a href="/wiki/GPR12" title="GPR12">12</a></li> <li><a href="/wiki/GPR15" title="GPR15">15</a></li> <li><a href="/wiki/GPR17" title="GPR17">17</a></li> <li><a href="/wiki/GPR18" class="mw-redirect" title="GPR18">18</a></li> <li><a href="/wiki/GPR19" title="GPR19">19</a></li> <li><a href="/wiki/GPR20" title="GPR20">20</a></li> <li><a href="/wiki/GPR21" title="GPR21">21</a></li> <li><a href="/wiki/GPR22" title="GPR22">22</a></li> <li><a href="/wiki/LPAR4" title="LPAR4">23</a></li> <li><a href="/wiki/GPR25" title="GPR25">25</a></li> <li><a href="/wiki/GPR26" title="GPR26">26</a></li> <li><a href="/wiki/GPR27" title="GPR27">27</a></li> <li><a href="/wiki/GPR31" title="GPR31">31</a></li> <li><a href="/wiki/GPR32" title="GPR32">32</a></li> <li><a href="/wiki/GPR33" title="GPR33">33</a></li> <li><a href="/wiki/GPR34" title="GPR34">34</a></li> <li><a href="/wiki/GPR35" title="GPR35">35</a></li> <li><a href="/wiki/GPR37" title="GPR37">37</a></li> <li><a href="/wiki/GPR39" title="GPR39">39</a></li> <li><a href="/wiki/GPR42" title="GPR42">42</a></li> <li><a href="/wiki/GPR44" class="mw-redirect" title="GPR44">44</a></li> <li><a href="/wiki/GPR45" title="GPR45">45</a></li> <li><a href="/wiki/GPR50" title="GPR50">50</a></li> <li><a href="/wiki/GPR52" title="GPR52">52</a></li> <li><a href="/wiki/GPR55" title="GPR55">55</a></li> <li><a href="/wiki/GPR61" title="GPR61">61</a></li> <li><a href="/wiki/GPR62" title="GPR62">62</a></li> <li><a href="/wiki/GPR63" title="GPR63">63</a></li> <li><a href="/wiki/GPR65" title="GPR65">65</a></li> <li><a href="/wiki/GPR68" title="GPR68">68</a></li> <li><a href="/wiki/GPR75" title="GPR75">75</a></li> <li><a href="/wiki/GPR78" title="GPR78">78</a></li> <li><a href="/wiki/GPR81" class="mw-redirect" title="GPR81">81</a></li> <li><a href="/wiki/GPR82" title="GPR82">82</a></li> <li><a href="/wiki/GPR83" title="GPR83">83</a></li> <li><a href="/wiki/GPR84" title="GPR84">84</a></li> <li><a href="/wiki/GPR85" title="GPR85">85</a></li> <li><a href="/wiki/GPR87" title="GPR87">87</a></li> <li><a href="/wiki/GPR88" title="GPR88">88</a></li> <li><a href="/wiki/LPAR5" title="LPAR5">92</a></li> <li><a href="/wiki/GPR101" title="GPR101">101</a></li> <li><a href="/wiki/Pyroglutamylated_RFamide_peptide_receptor" title="Pyroglutamylated RFamide peptide receptor">103</a></li> <li><a href="/wiki/Niacin_receptor_1" class="mw-redirect" title="Niacin receptor 1">109A</a></li> <li><a href="/wiki/Niacin_receptor_2" class="mw-redirect" title="Niacin receptor 2">109B</a></li> <li><a href="/wiki/GPR119" title="GPR119">119</a></li> <li><a href="/wiki/GPR120" class="mw-redirect" title="GPR120">120</a></li> <li><a href="/wiki/GPR132" title="GPR132">132</a></li> <li><a href="/wiki/GPR135" title="GPR135">135</a></li> <li><a href="/wiki/GPR137B" title="GPR137B">137B</a></li> <li><a href="/wiki/GPR139" title="GPR139">139</a></li> <li><a href="/wiki/GPR141" title="GPR141">141</a></li> <li><a href="/wiki/GPR142" title="GPR142">142</a></li> <li><a href="/wiki/GPR146" title="GPR146">146</a></li> <li><a href="/wiki/GPR148" title="GPR148">148</a></li> <li><a href="/wiki/GPR149" title="GPR149">149</a></li> <li><a href="/wiki/GPR150" title="GPR150">150</a></li> <li><a href="/wiki/GPR151" title="GPR151">151</a></li> <li><a href="/wiki/GPR152" title="GPR152">152</a></li> <li><a href="/wiki/GPR153" title="GPR153">153</a></li> <li><a href="/wiki/GPR160" title="GPR160">160</a></li> <li><a href="/wiki/GPR161" title="GPR161">161</a></li> <li><a href="/wiki/GPR162" title="GPR162">162</a></li> <li><a href="/wiki/GPR171" title="GPR171">171</a></li> <li><a href="/wiki/GPR173" title="GPR173">173</a></li> <li><a href="/wiki/GPR174" title="GPR174">174</a></li> <li><a href="/wiki/GPR176" title="GPR176">176</a></li> <li><a href="/wiki/GPR177" class="mw-redirect" title="GPR177">177</a></li> <li><a href="/wiki/GPR182" title="GPR182">182</a></li> <li><a href="/wiki/GPR183" title="GPR183">183</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:7em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GPR182" title="GPR182">Adrenomedullin</a></li> <li><a href="/wiki/Olfactory_receptor" title="Olfactory receptor">Olfactory</a></li> <li><a href="/wiki/Opsin" title="Opsin">Opsin</a> (<a href="/wiki/OPN3" title="OPN3">3</a></li> <li><a href="/wiki/Melanopsin" title="Melanopsin">4</a></li> <li><a href="/wiki/OPN5" title="OPN5">5</a></li> <li><a href="/wiki/OPN1LW" title="OPN1LW">1LW</a></li> <li><a href="/wiki/OPN1MW" title="OPN1MW">1MW</a></li> <li><a href="/wiki/OPN1SW" title="OPN1SW">1SW</a></li> <li><a href="/wiki/Retinal_G_protein_coupled_receptor" title="Retinal G protein coupled receptor">RGR</a></li> <li><a href="/wiki/RRH" title="RRH">RRH</a>)</li> <li><a href="/wiki/Protease-activated_receptor" title="Protease-activated receptor">Protease-activated</a> (<a href="/wiki/Coagulation_factor_II_receptor" class="mw-redirect" title="Coagulation factor II receptor">1</a></li> <li><a href="/wiki/Protease_activated_receptor_2" class="mw-redirect" title="Protease activated receptor 2">2</a></li> <li><a href="/wiki/F2RL2" title="F2RL2">3</a></li> <li><a href="/wiki/F2RL3" title="F2RL3">4</a>)</li> <li><a href="/wiki/Super_Conserved_Receptor_Expressed_in_Brain" title="Super Conserved Receptor Expressed in Brain">SREB</a> (<a href="/wiki/GPR27" title="GPR27">1</a></li> <li><a href="/wiki/GPR85" title="GPR85">2</a></li> <li><a href="/wiki/GPR173" title="GPR173">3</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_B:_Secretin-like" style="font-size:114%;margin:0 4em"><a href="/wiki/Secretin_receptor_family" title="Secretin receptor family">Class B</a>: <a href="/wiki/Secretin_receptor" title="Secretin receptor">Secretin</a>-like</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Adhesion_G_protein-coupled_receptor" title="Adhesion G protein-coupled receptor">Adhesion</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>ADGRB</i> <ul><li><a href="/wiki/Brain-specific_angiogenesis_inhibitor" title="Brain-specific angiogenesis inhibitor">Brain-specific angiogenesis inhibitor</a> <ul><li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_1" title="Brain-specific angiogenesis inhibitor 1">1</a></li> <li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_2" title="Brain-specific angiogenesis inhibitor 2">2</a></li> <li><a href="/wiki/Brain-specific_angiogenesis_inhibitor_3" title="Brain-specific angiogenesis inhibitor 3">3</a></li></ul></li></ul></li> <li><i>ADGRC</i> <ul><li><a href="/wiki/Flamingo_(protein)" title="Flamingo (protein)">Cadherin</a> <ul><li><a href="/wiki/CELSR1" title="CELSR1">1</a></li> <li><a href="/wiki/CELSR2" title="CELSR2">2</a></li> <li><a href="/wiki/CELSR3" title="CELSR3">3</a></li></ul></li></ul></li> <li><i>ADGRE</i> <ul><li><a href="/wiki/EGF_module-containing_mucin-like_hormone_receptor" title="EGF module-containing mucin-like hormone receptor">EMR</a> <ul><li><a href="/wiki/EMR1" title="EMR1">1</a></li> <li><a href="/wiki/EMR2" title="EMR2">2</a></li> <li><a href="/wiki/EMR3" title="EMR3">3</a></li></ul></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li></ul></li> <li><i>ADGRG</i> <ul><li><a href="/wiki/GPR56" title="GPR56">1</a></li> <li><a href="/wiki/GPR64" title="GPR64">2</a></li> <li><a href="/wiki/GPR97" title="GPR97">3</a></li> <li><a href="/wiki/GPR112" title="GPR112">4</a></li> <li><a href="/wiki/GPR114" title="GPR114">5</a></li> <li><a href="/wiki/GPR126" title="GPR126">6</a></li> <li><a href="/wiki/GPR128" title="GPR128">7</a></li></ul></li> <li><i>ADGRL</i> <ul><li><a href="/wiki/Latrophilin_receptor" class="mw-redirect" title="Latrophilin receptor">Latrophilin</a> <ul><li><a href="/wiki/Latrophilin_1" title="Latrophilin 1">1</a></li> <li><a href="/wiki/Latrophilin_2" title="Latrophilin 2">2</a></li> <li><a href="/wiki/Latrophilin_3" title="Latrophilin 3">3</a></li></ul></li> <li><a href="/wiki/ELTD1" class="mw-redirect" title="ELTD1">ELTD1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Orphan_receptor" title="Orphan receptor">Orphan</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>GPR</i> (<a href="/wiki/GPR56" title="GPR56">56</a></li> <li><a href="/wiki/GPR64" title="GPR64">64</a></li> <li><a href="/wiki/GPR97" title="GPR97">97</a></li> <li><a href="/wiki/GPR98" title="GPR98">98</a></li> <li><a href="/wiki/GPR110" title="GPR110">110</a></li> <li><a href="/wiki/GPR111" title="GPR111">111</a></li> <li><a href="/wiki/GPR112" title="GPR112">112</a></li> <li><a href="/wiki/GPR113" title="GPR113">113</a></li> <li><a href="/wiki/GPR114" title="GPR114">114</a></li> <li><a href="/wiki/GPR115" title="GPR115">115</a></li> <li><a href="/wiki/GPR116" title="GPR116">116</a></li> <li><a href="/wiki/GPR123" title="GPR123">123</a></li> <li><a href="/wiki/GPR124" title="GPR124">124</a></li> <li><a href="/wiki/GPR125" title="GPR125">125</a></li> <li><a href="/wiki/GPR126" title="GPR126">126</a></li> <li><a href="/wiki/GPR128" title="GPR128">128</a></li> <li><a href="/wiki/GPR133" title="GPR133">133</a></li> <li><a href="/wiki/GPR143" title="GPR143">143</a></li> <li><a href="/wiki/GPR144" title="GPR144">144</a></li> <li><a href="/wiki/GPR155" title="GPR155">155</a></li> <li><a href="/wiki/GPR157" title="GPR157">157</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcitonin_receptor" title="Calcitonin receptor">Calcitonin</a></li> <li><a href="/wiki/CALCRL" title="CALCRL">CALCRL</a></li> <li><a href="/wiki/Corticotropin-releasing_hormone_receptor" title="Corticotropin-releasing hormone receptor">Corticotropin-releasing hormone</a> (<a href="/wiki/Corticotropin-releasing_hormone_receptor_1" title="Corticotropin-releasing hormone receptor 1">1</a></li> <li><a href="/wiki/Corticotropin-releasing_hormone_receptor_2" title="Corticotropin-releasing hormone receptor 2">2</a>)</li> <li><a href="/wiki/Glucagon_receptor_family" title="Glucagon receptor family">Glucagon</a> (<a href="/wiki/Glucagon_receptor" title="Glucagon receptor">GR</a></li> <li><a href="/wiki/Gastric_inhibitory_polypeptide_receptor" title="Gastric inhibitory polypeptide receptor">GIPR</a></li> <li><a class="mw-selflink selflink">GLP1R</a></li> <li><a href="/wiki/Glucagon-like_peptide-2_receptor" title="Glucagon-like peptide-2 receptor">GLP2R</a>)</li> <li><a href="/wiki/Growth-hormone-releasing_hormone_receptor" title="Growth-hormone-releasing hormone receptor">Growth-hormone-releasing hormone</a></li> <li><a href="/wiki/ADCYAP1R1" title="ADCYAP1R1">PACAPR1</a></li> <li><a href="/wiki/Orphan_receptor" title="Orphan receptor">GPR</a></li> <li><a href="/wiki/Methuselah-like_proteins" title="Methuselah-like proteins">Methuselah-like proteins</a></li> <li><a href="/wiki/Parathyroid_hormone_receptor" title="Parathyroid hormone receptor">Parathyroid hormone</a> (<a href="/wiki/Parathyroid_hormone_1_receptor" title="Parathyroid hormone 1 receptor">1</a></li> <li><a href="/wiki/Parathyroid_hormone_2_receptor" title="Parathyroid hormone 2 receptor">2</a>)</li> <li><a href="/wiki/Secretin_receptor" title="Secretin receptor">Secretin</a></li> <li><a href="/wiki/Vasoactive_intestinal_peptide_receptor" title="Vasoactive intestinal peptide receptor">Vasoactive intestinal peptide</a> (<a href="/wiki/VIPR1" title="VIPR1">1</a></li> <li><a href="/wiki/VIPR2" title="VIPR2">2</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_C:_Metabotropic_glutamate_/_pheromone" style="font-size:114%;margin:0 4em"><a href="/wiki/Class_C_GPCR" title="Class C GPCR">Class C</a>: <a href="/wiki/Metabotropic_receptor" title="Metabotropic receptor">Metabotropic</a> <a href="/wiki/Metabotropic_glutamate_receptor" title="Metabotropic glutamate receptor">glutamate</a> / <a href="/wiki/Pheromone" title="Pheromone">pheromone</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><a href="/wiki/Taste_receptor" title="Taste receptor">Taste</a>, sweet</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>TAS1R</i> <ul><li><a href="/wiki/TAS1R1" title="TAS1R1">1</a></li> <li><a href="/wiki/TAS1R2" title="TAS1R2">2</a></li> <li><a href="/wiki/TAS1R3" title="TAS1R3">3</a></li></ul></li> <li><a href="/wiki/Vomeronasal_receptor" title="Vomeronasal receptor">Vomeronasal receptor</a>, type 2</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;"><i>Other</i></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Calcium-sensing_receptor" title="Calcium-sensing receptor">Calcium-sensing receptor</a></li> <li><a href="/wiki/GABA_receptor" title="GABA receptor">GABA<sub>B</sub></a> (<a href="/wiki/GABBR1" title="GABBR1">1</a></li> <li><a href="/wiki/GABBR2" title="GABBR2">2</a>)</li> <li><a href="/wiki/Glutamate_receptor" title="Glutamate receptor">Glutamate receptor</a> (<a href="/wiki/Metabotropic_glutamate_receptor" title="Metabotropic glutamate receptor">Metabotropic glutamate</a> (<a href="/wiki/Metabotropic_glutamate_receptor_1" title="Metabotropic glutamate receptor 1">1</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_2" title="Metabotropic glutamate receptor 2">2</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_3" title="Metabotropic glutamate receptor 3">3</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_4" title="Metabotropic glutamate receptor 4">4</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_5" title="Metabotropic glutamate receptor 5">5</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_6" title="Metabotropic glutamate receptor 6">6</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_7" title="Metabotropic glutamate receptor 7">7</a></li> <li><a href="/wiki/Metabotropic_glutamate_receptor_8" title="Metabotropic glutamate receptor 8">8</a>))</li> <li><a href="/wiki/GPRC6A" title="GPRC6A">GPRC6A</a></li> <li><a href="/wiki/Orphan_receptor" title="Orphan receptor">GPR</a> (<a href="/wiki/GPR156" title="GPR156">156</a></li> <li><a href="/wiki/GPR158" title="GPR158">158</a></li> <li><a href="/wiki/GPR179" title="GPR179">179</a>)</li> <li><a href="/wiki/Retinoic_acid-inducible_orphan_G_protein-coupled_receptor" title="Retinoic acid-inducible orphan G protein-coupled receptor">RAIG</a> (<a href="/wiki/GPRC5A" title="GPRC5A">1</a></li> <li><a href="/wiki/GPRC5B" title="GPRC5B">2</a></li> <li><a href="/wiki/GPRC5C" title="GPRC5C">3</a></li> <li><a href="/wiki/GPRC5D" title="GPRC5D">4</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Class_F:_Frizzled_&amp;_Smoothened" style="font-size:114%;margin:0 4em">Class F: <a href="/wiki/Frizzled" title="Frizzled">Frizzled</a> & <a href="/wiki/Smoothened" title="Smoothened">Smoothened</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10em;text-align:left;">Frizzled</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Frizzled" title="Frizzled">Frizzled</a> (<a href="/wiki/FZD1" class="mw-redirect" title="FZD1">1</a></li> <li><a href="/wiki/FZD2" class="mw-redirect" title="FZD2">2</a></li> <li><a href="/wiki/FZD3" class="mw-redirect" title="FZD3">3</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">4</a></li> <li><a href="/wiki/FZD5" class="mw-redirect" title="FZD5">5</a></li> <li><a href="/wiki/FZD6" class="mw-redirect" title="FZD6">6</a></li> <li><a href="/wiki/FZD7" class="mw-redirect" title="FZD7">7</a></li> <li><a href="/wiki/FZD8" class="mw-redirect" title="FZD8">8</a></li> <li><a href="/wiki/FZD9" 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