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<div class="article-content"> <div id="figure-carousel-section"> <h2>Figures</h2> <div id="figure-carousel"> <div class="carousel-wrapper"> <div class="slider"> <div class="carousel-item lightbox-figure" data-doi="10.1371/journal.pbio.0020089.t001"> <img src="/plosbiology/article/figure/image?size=inline&id=10.1371/journal.pbio.0020089.t001" loading="lazy" alt="Table 3" /> </div> </div> </div> <div class="carousel-control"> <span class="button previous"></span> <span class="button next"></span> </div> <div class="carousel-page-buttons"> </div> </div> </div> <script src="/resource/js/vendor/jquery.touchswipe.js" type="text/javascript"></script> <script src="/resource/js/components/figure_carousel.js" type="text/javascript"></script> <script src="/resource/js/vendor/jquery.dotdotdot.js" type="text/javascript"></script> <div class="article-text" id="artText"> <div xmlns:plos="http://plos.org" id="section1" class="section toc-section"><a id="article1.body1.sec1.p1" name="article1.body1.sec1.p1" class="link-target"></a><p> <strong>In <em>PLoS Biology,</em> volume 1, issue 1:</strong> </p> <a id="article1.body1.sec1.p2" name="article1.body1.sec1.p2" class="link-target"></a><p>The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway</p> <a id="article1.body1.sec1.p3" name="article1.body1.sec1.p3" class="link-target"></a><p> <strong>Ethan Lee, Adrian Salic, Roland Krüger, Reinhart Heinrich, Marc W. Kirschner</strong> </p> <a id="article1.body1.sec1.p4" name="article1.body1.sec1.p4" class="link-target"></a><p> <strong>DOI: 10.1371/journal.pbio.0000010</strong> </p> <a id="article1.body1.sec1.p5" name="article1.body1.sec1.p5" class="link-target"></a><p>Table 1: In the legend, the words <em>fluxes</em> and <em>flux</em> appeared without the <em>fl</em>.</p> <a id="article1.body1.sec1.p6" name="article1.body1.sec1.p6" class="link-target"></a><p>Table 3: In the legend, the word <em>coefficients</em> appeared without the <em>fi</em>. In the table, some numbers in the section “Binding, dissociation” were marked with a ± sign that should have been a ∓.</p> <a id="article1.body1.sec1.p7" name="article1.body1.sec1.p7" class="link-target"></a><p>Table 4: In the legend, the word <em>coefficients</em> appeared without the <em>fi</em>.</p> <a id="article1.body1.sec1.p8" name="article1.body1.sec1.p8" class="link-target"></a><p>Please see the corrected legends and table below.</p> <a id="article1.body1.sec1.p9" name="article1.body1.sec1.p9" class="link-target"></a><p><strong>Table 1.</strong> Numeric Values of Input Quantities of the Model for the Reference State</p> <a id="article1.body1.sec1.p10" name="article1.body1.sec1.p10" class="link-target"></a><p>The data are grouped into concentrations of pathway components, dissociation constants of protein complexes, concentration ratios, fluxes and flux ratios, and characteristic times of selected processes. Experimental evidence for these data is discussed in the text. From these data, the following rates and rate constants are calculated: <strong>v</strong><sub>12</sub> = 0.42 nM · min<sup>−1</sup> (rate of β-catenin synthesis), <strong>v</strong><sub>14</sub> = 8.2 · 10<sup>−5</sup> · nM · min<sup>−1</sup> (rate of axin synthesis), <em>k</em><sub>4</sub> = 0.27 min<sup>−1</sup>, <em>k</em><sub>5</sub> = 0.13 min<sup>−1</sup>, <em>k</em><sub>6</sub> = 9.1 · 10<sup>−2</sup> nM<sup>−1</sup> · min<sup>−1</sup>, <em>k</em><sub>−6</sub> = 0.91 · nM<sup>−1</sup> · min<sup>−1</sup>, <em>k</em><sub>9</sub> = 210 min<sup>−1</sup>, <em>k</em><sub>10</sub> = 210 min<sup>−1</sup>, <em>k</em><sub>11</sub> · 0.42 min<sup>−1</sup>, <em>k</em><sub>13</sub> = 2.6 · 10<sup>−4</sup> min<sup>−1</sup>, <em>k</em><sub>15</sub> = 0.17 · min<sup>−1</sup>. See Table S2, found at <a href="http://dx.doi.org/10.1371/journal.pbio.0000010.t002">http://dx.doi.org/10.1371/journal.pbio.0000010.t002</a>, for more precise numbers used in the calculations.</p> <a id="article1.body1.sec1.p11" name="article1.body1.sec1.p11" class="link-target"></a><p><strong>Bold:</strong> Measured values, <em>Italics:</em> Estimated values.</p> <a id="article1.body1.sec1.p12" name="article1.body1.sec1.p12" class="link-target"></a><p>DOI: 10.1371/journal.pbio.0000010.t001</p> <a id="article1.body1.sec1.p13" name="article1.body1.sec1.p13" class="link-target"></a><p> <a href="#pbio-0020089-t001"></a> </p> <a class="link-target" id="pbio-0020089-t001" name="pbio-0020089-t001"></a><div class="figure" data-doi="10.1371/journal.pbio.0020089.t001"><div class="img-box"><a title="Click for larger image" href="article/figure/image?size=medium&id=10.1371/journal.pbio.0020089.t001" data-doi="10.1371/journal.pbio.0020089" data-uri="10.1371/journal.pbio.0020089.t001"><img src="article/figure/image?size=inline&id=10.1371/journal.pbio.0020089.t001" alt="thumbnail" class="thumbnail" loading="lazy"></a><div class="expand"></div></div><div class="figure-inline-download"> Download: <ul><li><a href="article/figure/powerpoint?id=10.1371/journal.pbio.0020089.t001"><div class="definition-label">PPT</div><div class="definition-description">PowerPoint slide</div></a></li><li><a href="article/figure/image?download&size=large&id=10.1371/journal.pbio.0020089.t001"><div class="definition-label">PNG</div><div class="definition-description">larger image</div></a></li><li><a href="article/figure/image?download&size=original&id=10.1371/journal.pbio.0020089.t001"><div class="definition-label">TIFF</div><div class="definition-description">original image</div></a></li></ul></div><div class="figcaption"><span>Table 3. </span> Control Coefficients for the Total Concentrations of β-Catenin and Axin and Parameters Quantifying the Sensitivity and the Robustness of the Wnt/β-Catenin Pathway</div><p class="caption_target"></p><p class="caption_object"><a href="https://doi.org/10.1371/journal.pbio.0020089.t001"> https://doi.org/10.1371/journal.pbio.0020089.t001</a></p></div><a id="article1.body1.sec1.p14" name="article1.body1.sec1.p14" class="link-target"></a><p><strong>Table 4.</strong> Concentration Control Coefficients for the Total Concentrations of β-Catenin and Axin Relative to Changes in the Concentrations of Pathway Components</p> <a id="article1.body1.sec1.p15" name="article1.body1.sec1.p15" class="link-target"></a><p>The control coefficients were obtained by numerical determination of the response to a change of total concentrations by 1%. Coefficients are given for the reference state and for the standard stimulated state.</p> <a id="article1.body1.sec1.p16" name="article1.body1.sec1.p16" class="link-target"></a><p>DOI: 10.1371/journal.pbio.0000010.t004</p> <a id="article1.body1.sec1.p17" name="article1.body1.sec1.p17" class="link-target"></a><p>The full text XML and HTML versions of the article have been corrected online. This correction note may be found at DOI: 10.1371/journal.pbio.0020089.</p> </div> <div xmlns:plos="http://plos.org" class="articleinfo"><p><strong>Citation: </strong> (2004) Corrections: The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway. PLoS Biol 2(3): e89. https://doi.org/10.1371/journal.pbio.0020089</p><p><strong>Published: </strong> March 16, 2004</p><p><strong>Copyright: </strong> © 2004 Public Library of Science. 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