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class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Sommaire" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Basculer la table des matières" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Basculer la table des matières</span> </label> <div class="vector-dropdown-content"> <div 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Disponible en 9 langues." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-9" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">9 langues</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%AA%D9%84%D8%A7%D8%B2%D9%85%D8%A9_%D8%AA%D8%A7%D8%B1" title="متلازمة تار – arabe" lang="ar" hreflang="ar" data-title="متلازمة تار" data-language-autonym="العربية" data-language-local-name="arabe" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/TAR_sindrom" title="TAR sindrom – bosniaque" lang="bs" hreflang="bs" data-title="TAR sindrom" data-language-autonym="Bosanski" data-language-local-name="bosniaque" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/TAR-Syndrom" title="TAR-Syndrom – allemand" lang="de" hreflang="de" data-title="TAR-Syndrom" data-language-autonym="Deutsch" data-language-local-name="allemand" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/TAR_syndrome" title="TAR syndrome – anglais" lang="en" hreflang="en" data-title="TAR syndrome" data-language-autonym="English" data-language-local-name="anglais" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/S%C3%ADndrome_TAR" title="Síndrome TAR – espagnol" lang="es" hreflang="es" data-title="Síndrome TAR" data-language-autonym="Español" data-language-local-name="espagnol" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/S%C3%ADndrome_TAR" title="Síndrome TAR – galicien" lang="gl" hreflang="gl" data-title="Síndrome TAR" data-language-autonym="Galego" data-language-local-name="galicien" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Sindrome_trombocitopenica_con_assenza_di_radio" title="Sindrome trombocitopenica con assenza di radio – italien" lang="it" hreflang="it" data-title="Sindrome trombocitopenica con assenza di radio" data-language-autonym="Italiano" data-language-local-name="italien" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/TAR-syndroom" title="TAR-syndroom – néerlandais" lang="nl" hreflang="nl" data-title="TAR-syndroom" data-language-autonym="Nederlands" data-language-local-name="néerlandais" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Zesp%C3%B3%C5%82_ma%C5%82op%C5%82ytkowo%C5%9Bci_i_aplazji_ko%C5%9Bci_promieniowej" title="Zespół małopłytkowości i aplazji kości promieniowej – polonais" lang="pl" hreflang="pl" data-title="Zespół małopłytkowości i aplazji kości promieniowej" data-language-autonym="Polski" data-language-local-name="polonais" class="interlanguage-link-target"><span>Polski</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a 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mw-parser-output" lang="fr" dir="ltr"><div class="bandeau-container metadata bandeau-article bandeau-niveau-ebauche"><div class="bandeau-cell bandeau-icone" style="display:table-cell;padding-right:0.5em"><span class="noviewer" typeof="mw:File"><a href="/wiki/Fichier:Star_of_life2.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/35px-Star_of_life2.svg.png" decoding="async" width="35" height="35" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/53px-Star_of_life2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/70px-Star_of_life2.svg.png 2x" data-file-width="192" data-file-height="192" /></a></span></div><div class="bandeau-cell" style="display:table-cell;padding-right:0.5em"> <p><strong class="bandeau-titre">Cet article est une <a href="/wiki/Aide:%C3%89bauche" title="Aide:Ébauche">ébauche</a> concernant la <a href="/wiki/M%C3%A9decine" title="Médecine">médecine</a>.</strong> </p><p>Vous pouvez partager vos connaissances en l’améliorant (<b><a href="/wiki/Aide:Comment_modifier_une_page" title="Aide:Comment modifier une page">comment ?</a></b>) selon les recommandations des <a href="/wiki/Projet:Accueil" title="Projet:Accueil">projets correspondants</a>. </p> </div></div> <div class="infobox_v3 infobox infobox--frwiki noarchive large" style="width:22em"> <div class="entete icon defaut" style="background-color: lightgrey; color: #000000;"> <div>Syndrome TAR<br />(Thrombocytopénie avec Absence de Radius)</div> </div> <p class="mw-empty-elt"> </p> <table><caption class="hidden" style="">Données clés</caption> <tbody><tr> <th scope="row"><a href="/wiki/Sympt%C3%B4me" title="Symptôme">Symptômes</a></th> <td> <span class="wd_p780"><a href="/wiki/Thrombop%C3%A9nie" title="Thrombopénie">Thrombopénie</a> et aplasie radiale <small>(<a href="https://en.wikipedia.org/wiki/Radial_aplasia" class="extiw" title="en:Radial aplasia"><span class="indicateur-langue" title="Article sur Wikipédia en anglais">en</span></a>)</small><span class="noprint wikidata-linkback skin-invert"><span class="mw-valign-baseline noviewer" typeof="mw:File"><a href="https://www.wikidata.org/wiki/Q660330?uselang=fr#P780" title="Voir et modifier les données sur Wikidata"><img alt="Voir et modifier les données sur Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></span></span></td> </tr> </tbody></table><p class="mw-empty-elt"> </p><table><caption style="background-color:lightgrey;">Traitement</caption> <tbody><tr> <th scope="row"><a href="/wiki/Sp%C3%A9cialit%C3%A9_m%C3%A9dicale" title="Spécialité médicale">Spécialité</a></th> <td> <span class="wd_p1995"><a href="/wiki/G%C3%A9n%C3%A9tique_m%C3%A9dicale" title="Génétique médicale">Génétique médicale</a><span class="noprint wikidata-linkback skin-invert"><span class="mw-valign-baseline noviewer" typeof="mw:File"><a href="https://www.wikidata.org/wiki/Q660330?uselang=fr#P1995" title="Voir et modifier les données sur Wikidata"><img alt="Voir et modifier les données sur Wikidata" src="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/10px-Blue_pencil.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/15px-Blue_pencil.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/73/Blue_pencil.svg/20px-Blue_pencil.svg.png 2x" data-file-width="600" data-file-height="600" /></a></span></span></span></td> </tr> </tbody></table> <table><caption style="background-color:lightgrey;">Classification et ressources externes</caption> <tbody><tr> <th scope="row"><a href="/wiki/Classification_internationale_des_maladies" title="Classification internationale des maladies">CIM</a>-<a href="/wiki/Liste_de_codes_CIM-10" title="Liste de codes CIM-10">10</a></th> <td> <a rel="nofollow" class="external text" href="http://apps.who.int/classifications/icd10/browse/2008/fr#/Q87.2">Q87.2</a></td> </tr> <tr> <th scope="row"><a href="/wiki/Classification_internationale_des_maladies" title="Classification internationale des maladies">CIM</a>-<a href="/wiki/Liste_de_codes_CIM-9" title="Liste de codes CIM-9">9</a></th> <td> <a rel="nofollow" class="external text" href="http://www.icd9data.com/getICD9Code.ashx?icd9=287.33">287.33</a></td> </tr> <tr> <th scope="row"><a href="/wiki/H%C3%A9ritage_mend%C3%A9lien_chez_l%27humain" title="Héritage mendélien chez l'humain">OMIM</a></th> <td> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/274000">274000</a></td> </tr> <tr> <th scope="row">DiseasesDB</th> <td> <a rel="nofollow" class="external text" href="http://www.diseasesdatabase.com/ddb29769.htm">29769</a></td> </tr> <tr> <th scope="row"><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></th> <td> <a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=C536940">C536940</a></td> </tr> </tbody></table> <p class="bloc" style="background-color:lightgrey; color:#FFFFFF;"><span typeof="mw:File"><a href="/wiki/Wikip%C3%A9dia:Mise_en_garde_m%C3%A9dicale" title="Wikipédia ne donne pas de conseils médicaux"><img alt="Wikipédia ne donne pas de conseils médicaux" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/24px-Star_of_life_caution.svg.png" decoding="async" width="24" height="22" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/36px-Star_of_life_caution.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d5/Star_of_life_caution.svg/48px-Star_of_life_caution.svg.png 2x" data-file-width="210" data-file-height="190" /></a></span> <a href="/wiki/Wikip%C3%A9dia:Mise_en_garde_m%C3%A9dicale" title="Wikipédia:Mise en garde médicale">Mise en garde médicale</a></p> <p class="navbar bordered noprint" style="border-color:lightgrey;"><span class="plainlinks"><a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Syndrome_TAR&veaction=edit&section=0">modifier</a> - <a class="external text" href="https://fr.wikipedia.org/w/index.php?title=Syndrome_TAR&action=edit&section=0">modifier le code</a> - <a href="https://www.wikidata.org/wiki/Special:ItemByTitle/frwiki/Syndrome_TAR" class="extiw" title="d:Special:ItemByTitle/frwiki/Syndrome TAR">voir Wikidata</a> <a href="/wiki/Aide:Infobox_Wikidata" title="Aide:Infobox Wikidata">(aide)</a></span> <span typeof="mw:File"><a href="/wiki/Mod%C3%A8le:Infobox_Maladie" title="Consultez la documentation du modèle"><img alt="" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/12px-Info_Simple.svg.png" decoding="async" width="12" height="12" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/18px-Info_Simple.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Info_Simple.svg/24px-Info_Simple.svg.png 2x" data-file-width="512" data-file-height="512" /></a></span></p></div> <p>Le <b>syndrome TAR</b> est un <a href="/wiki/Syndrome" title="Syndrome">syndrome</a> décrit pour la première fois en <a href="/wiki/1959" title="1959">1959</a> et qui associe une <a href="/wiki/Thrombop%C3%A9nie" title="Thrombopénie">thrombopénie</a> et une absence de <a href="/wiki/Os_radius" class="mw-redirect" title="Os radius">radius</a>. L'absence de radius est primitif et non pas secondaire à un défaut de vascularisation. Environ 40 % des nouveau-nés décèdent les premiers jours. </p><p>La tétraphocomélie avec thrombopénie est une maladie associée au syndrome TAR. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Description">Description</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Syndrome_TAR&veaction=edit&section=1" title="Modifier la section : Description" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Syndrome_TAR&action=edit&section=1" title="Modifier le code source de la section : Description"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Outre les anomalies caractéristiques, on retrouve fréquemment une <a href="/wiki/Cardiopathie_cong%C3%A9nitale" title="Cardiopathie congénitale">cardiopathie</a> de type <a href="/wiki/T%C3%A9tralogie_de_Fallot" title="Tétralogie de Fallot">tétralogie de Fallot</a>. Des anomalies des membres inférieurs sont parfois présentes et sévères. L'intolérance au lait de vache est fréquente. Les anomalies plus rares sont : <a href="/wiki/Angiome" title="Angiome">angiome</a> de la face, malformation vasculaire cérébrale et <a href="/wiki/Surdit%C3%A9" title="Surdité">surdité</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Diagnostic_différentiel"><span id="Diagnostic_diff.C3.A9rentiel"></span>Diagnostic différentiel</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Syndrome_TAR&veaction=edit&section=2" title="Modifier la section : Diagnostic différentiel" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Syndrome_TAR&action=edit&section=2" title="Modifier le code source de la section : Diagnostic différentiel"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Cette pathologie est à différencier avec la <a href="/wiki/An%C3%A9mie_de_Fanconi" title="Anémie de Fanconi">maladie de Fanconi</a> car la thrombopénie est transitoire et il n'existe pas d'atteinte des autres cellules <a href="/wiki/Sang" title="Sang">sanguines</a>. La <a href="/w/index.php?title=Division_palatine&action=edit&redlink=1" class="new" title="Division palatine (page inexistante)">division palatine</a> ne fait pas partie de la description de ce syndrome et doit faire discuter le <a href="/wiki/Syndrome_de_Roberts" title="Syndrome de Roberts">syndrome de Roberts</a>, la <a href="/w/index.php?title=Phocom%C3%A9lie_SC&action=edit&redlink=1" class="new" title="Phocomélie SC (page inexistante)">phocomélie SC</a> ou la <a href="/wiki/Trisomie_18" title="Trisomie 18">trisomie 18</a>. </p><p>Le <a href="/wiki/Syndrome_de_Holt-Oram" title="Syndrome de Holt-Oram">syndrome de Holt-Oram</a> en raison de l'association anomalies des membres et cardiopathie. </p> <div class="mw-heading mw-heading2"><h2 id="Mode_de_transmission">Mode de transmission</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Syndrome_TAR&veaction=edit&section=3" title="Modifier la section : Mode de transmission" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Syndrome_TAR&action=edit&section=3" title="Modifier le code source de la section : Mode de transmission"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Bien qu'à l'origine une <a href="/wiki/Transmission_autosomique_r%C3%A9cessive" title="Transmission autosomique récessive">transmission autosomique récessive</a> ait été possible, de nombreux arguments ne sont pas en faveur de ce type de transmission. </p> <div class="mw-heading mw-heading2"><h2 id="Références"><span id="R.C3.A9f.C3.A9rences"></span>Références</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Syndrome_TAR&veaction=edit&section=4" title="Modifier la section : Références" class="mw-editsection-visualeditor"><span>modifier</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Syndrome_TAR&action=edit&section=4" title="Modifier le code source de la section : Références"><span>modifier le code</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: 274000 <a rel="nofollow" class="external autonumber" href="https://www.ncbi.nlm.nih.gov/omim/274000">[1]</a></li> <li><abbr class="abbr indicateur-langue" title="Langue : anglais">(en)</abbr> Genereview <a rel="nofollow" class="external autonumber" href="https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=tar">[2]</a></li></ul> <ul id="bandeau-portail" class="bandeau-portail"><li><span class="bandeau-portail-element"><span class="bandeau-portail-icone"><span class="noviewer" typeof="mw:File"><a href="/wiki/Portail:M%C3%A9decine" title="Portail de la médecine"><img alt="icône décorative" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/24px-Star_of_life2.svg.png" decoding="async" width="24" height="24" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/36px-Star_of_life2.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5b/Star_of_life2.svg/48px-Star_of_life2.svg.png 2x" data-file-width="192" data-file-height="192" /></a></span></span> <span class="bandeau-portail-texte"><a href="/wiki/Portail:M%C3%A9decine" title="Portail:Médecine">Portail de la médecine</a></span> </span></li> </ul>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Ce document provient de « <a dir="ltr" href="https://fr.wikipedia.org/w/index.php?title=Syndrome_TAR&oldid=155167584">https://fr.wikipedia.org/w/index.php?title=Syndrome_TAR&oldid=155167584</a> ».</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Cat%C3%A9gorie:Accueil" title="Catégorie:Accueil">Catégories</a> : <ul><li><a href="/wiki/Cat%C3%A9gorie:Maladie_g%C3%A9n%C3%A9tique" title="Catégorie:Maladie génétique">Maladie génétique</a></li><li><a href="/wiki/Cat%C3%A9gorie:Syndrome" title="Catégorie:Syndrome">Syndrome</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Catégories cachées : <ul><li><a href="/wiki/Cat%C3%A9gorie:Wikip%C3%A9dia:%C3%A9bauche_m%C3%A9decine" title="Catégorie:Wikipédia:ébauche médecine">Wikipédia:ébauche médecine</a></li><li><a href="/wiki/Cat%C3%A9gorie:Page_utilisant_P780" title="Catégorie:Page utilisant P780">Page utilisant P780</a></li><li><a href="/wiki/Cat%C3%A9gorie:Page_utilisant_P1995" title="Catégorie:Page utilisant P1995">Page utilisant P1995</a></li><li><a href="/wiki/Cat%C3%A9gorie:Article_utilisant_une_Infobox" title="Catégorie:Article utilisant une Infobox">Article utilisant une Infobox</a></li><li><a href="/wiki/Cat%C3%A9gorie:Portail:M%C3%A9decine/Articles_li%C3%A9s" title="Catégorie:Portail:Médecine/Articles liés">Portail:Médecine/Articles liés</a></li><li><a href="/wiki/Cat%C3%A9gorie:Portail:Biologie/Articles_li%C3%A9s" title="Catégorie:Portail:Biologie/Articles liés">Portail:Biologie/Articles liés</a></li><li><a href="/wiki/Cat%C3%A9gorie:Portail:Sciences/Articles_li%C3%A9s" title="Catégorie:Portail:Sciences/Articles liés">Portail:Sciences/Articles liés</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> La dernière modification de cette page a été faite le 27 décembre 2018 à 17:22.</li> <li id="footer-info-copyright"><span style="white-space: normal"><a href="/wiki/Wikip%C3%A9dia:Citation_et_r%C3%A9utilisation_du_contenu_de_Wikip%C3%A9dia" title="Wikipédia:Citation et réutilisation du contenu de Wikipédia">Droit d'auteur</a> : les textes sont disponibles sous <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.fr">licence Creative Commons attribution, partage dans les mêmes conditions</a> ; d’autres conditions peuvent s’appliquer. 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