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Bntishjoumalof Addiction79(1984), 261-273 © 1984 Society for the Study of Addiction to Alcohol and other Drugs. Relapse Prevention: Introduction and Overview of the Model G. Alan Marlatt and William H. 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class="InlineList-item-text" data-has-card-for-ri="71343" href="https://www.academia.edu/Documents/in/Liver_Cirrhosis">Liver Cirrhosis</a>, <script data-card-contents-for-ri="71343" type="text/json">{"id":71343,"name":"Liver Cirrhosis","url":"https://www.academia.edu/Documents/in/Liver_Cirrhosis?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="93659" href="https://www.academia.edu/Documents/in/Digestive_and_Liver_Diseases">Digestive and Liver Diseases</a>, <script data-card-contents-for-ri="93659" type="text/json">{"id":93659,"name":"Digestive and Liver Diseases","url":"https://www.academia.edu/Documents/in/Digestive_and_Liver_Diseases?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="202276" href="https://www.academia.edu/Documents/in/Varicose_Veins">Varicose Veins</a><script data-card-contents-for-ri="202276" type="text/json">{"id":202276,"name":"Varicose 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Therapy","url":"https://www.academia.edu/Documents/in/Drug_Therapy?f_ri=234187"},{"id":1004785,"name":"Hemorrhage","url":"https://www.academia.edu/Documents/in/Hemorrhage?f_ri=234187"},{"id":2471455,"name":"Acute Disease","url":"https://www.academia.edu/Documents/in/Acute_Disease?f_ri=234187"},{"id":2922786,"name":"Esophageal varices","url":"https://www.academia.edu/Documents/in/Esophageal_varices?f_ri=234187"},{"id":3589281,"name":"Ligation","url":"https://www.academia.edu/Documents/in/Ligation?f_ri=234187"},{"id":3928330,"name":"Antibiotic Therapy","url":"https://www.academia.edu/Documents/in/Antibiotic_Therapy-1?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_18935545 coauthored" data-work_id="18935545" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/18935545/Glycopyrrolate_and_Theophylline_for_the_Treatment_of_Severe_Pallid_Breath_holding_Spells">Glycopyrrolate and Theophylline for the Treatment of Severe Pallid Breath-holding Spells</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Severe pallid breath-holding spells (BHSs) are based on parasympathetic hyperactivity, leading to cardiac asystole, pallor, brain ischemia, loss of consciousness, and reflex anoxic seizures. In recent years, an increasing number of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_18935545" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Severe pallid breath-holding spells (BHSs) are based on parasympathetic hyperactivity, leading to cardiac asystole, pallor, brain ischemia, loss of consciousness, and reflex anoxic seizures. In recent years, an increasing number of patients with severe pallid BHSs have been successfully treated with pacemaker implantation. We present the case of a 13-month-old girl suffering from repeated severe pallid BHSs, causing asystole, loss of consciousness, and generalized anoxic seizures. She underwent treatment with oral glycopyrrolate, an anticholinergic drug, and an oral retard preparation of theophylline. The aim of the treatment was to decrease cardiac inhibition with glycopyrrolate and to bring about a positive chronotropic effect with theophylline. In our case, the combined therapy was effective in suppressing syncope and reflex anoxic seizures associated with BHSs This avoided the need for ventricular pacemaker implantation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/18935545" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6d595edcd96d8aa193a0cd7961a275f7" rel="nofollow" data-download="{"attachment_id":42126093,"asset_id":18935545,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42126093/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="39066369" href="https://independent.academia.edu/NicolaCarano">Nicola Carano</a><script data-card-contents-for-user="39066369" type="text/json">{"id":39066369,"first_name":"Nicola","last_name":"Carano","domain_name":"independent","page_name":"NicolaCarano","display_name":"Nicola Carano","profile_url":"https://independent.academia.edu/NicolaCarano?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-18935545">+1</span><div class="hidden js-additional-users-18935545"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/BertrandTchana">Bertrand Tchana</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-18935545'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-18935545').html(); 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In recent years, an increasing number of patients with severe pallid BHSs have been successfully treated with pacemaker implantation. We present the case of a 13-month-old girl suffering from repeated severe pallid BHSs, causing asystole, loss of consciousness, and generalized anoxic seizures. She underwent treatment with oral glycopyrrolate, an anticholinergic drug, and an oral retard preparation of theophylline. The aim of the treatment was to decrease cardiac inhibition with glycopyrrolate and to bring about a positive chronotropic effect with theophylline. In our case, the combined therapy was effective in suppressing syncope and reflex anoxic seizures associated with BHSs This avoided the need for ventricular pacemaker implantation.","downloadable_attachments":[{"id":42126093,"asset_id":18935545,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":39066369,"first_name":"Nicola","last_name":"Carano","domain_name":"independent","page_name":"NicolaCarano","display_name":"Nicola Carano","profile_url":"https://independent.academia.edu/NicolaCarano?f_ri=234187","photo":"/images/s65_no_pic.png"},{"id":39070091,"first_name":"Bertrand","last_name":"Tchana","domain_name":"independent","page_name":"BertrandTchana","display_name":"Bertrand 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Holding","url":"https://www.academia.edu/Documents/in/Breath_Holding?f_ri=234187"},{"id":1454403,"name":"Syncope","url":"https://www.academia.edu/Documents/in/Syncope?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_58550804" data-work_id="58550804" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/58550804/Results_of_Crawford_tube_intubation_in_children">Results of Crawford tube intubation in children</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/58550804" 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Frangou","profile_url":"https://mssm.academia.edu/SophiaFrangou?f_ri=234187","photo":"https://0.academia-photos.com/295792/2215424/2594920/s65_sophia.frangou.jpg"}],"research_interests":[{"id":3230,"name":"Bipolar Disorder","url":"https://www.academia.edu/Documents/in/Bipolar_Disorder?f_ri=234187","nofollow":false},{"id":192721,"name":"Risk factors","url":"https://www.academia.edu/Documents/in/Risk_factors?f_ri=234187","nofollow":false},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=234187","nofollow":false},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors?f_ri=234187"},{"id":419814,"name":"Bipolar Disorders","url":"https://www.academia.edu/Documents/in/Bipolar_Disorders?f_ri=234187"},{"id":620049,"name":"Risk 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href="https://www.academia.edu/6805713/Balloon_angioplasty_for_the_treatment_of_coronary_in_stent_restenosis_immediate_results_and_6_month_angiographic_recurrent_restenosis_rate">Balloon angioplasty for the treatment of coronary in-stent restenosis: immediate results and 6-month angiographic recurrent restenosis rate</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6805713" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="7fea94135b7cb7cd044dd6b939fd51b0" rel="nofollow" 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window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_6805713"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_6805713 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="6805713"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 6805713; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=6805713]").text(description); $(".js-view-count-work_6805713").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_6805713").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="6805713"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="606" href="https://www.academia.edu/Documents/in/Cardiology">Cardiology</a>, <script data-card-contents-for-ri="606" type="text/json">{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="27521" href="https://www.academia.edu/Documents/in/Stents">Stents</a>, <script data-card-contents-for-ri="27521" type="text/json">{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=6805713]'), work: {"id":6805713,"title":"Balloon angioplasty for the treatment of coronary in-stent restenosis: immediate results and 6-month angiographic recurrent restenosis rate","created_at":"2014-04-19T08:23:06.067-07:00","url":"https://www.academia.edu/6805713/Balloon_angioplasty_for_the_treatment_of_coronary_in_stent_restenosis_immediate_results_and_6_month_angiographic_recurrent_restenosis_rate?f_ri=234187","dom_id":"work_6805713","summary":null,"downloadable_attachments":[{"id":48716526,"asset_id":6805713,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":11273064,"first_name":"Vivek","last_name":"Gupta","domain_name":"independent","page_name":"VivekGupta38","display_name":"Vivek Gupta","profile_url":"https://independent.academia.edu/VivekGupta38?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":606,"name":"Cardiology","url":"https://www.academia.edu/Documents/in/Cardiology?f_ri=234187","nofollow":false},{"id":27521,"name":"Stents","url":"https://www.academia.edu/Documents/in/Stents?f_ri=234187","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=234187","nofollow":false},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=234187","nofollow":false},{"id":161176,"name":"The","url":"https://www.academia.edu/Documents/in/The?f_ri=234187"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187"},{"id":374984,"name":"Coronary Angiography","url":"https://www.academia.edu/Documents/in/Coronary_Angiography?f_ri=234187"},{"id":398808,"name":"Coronary heart disease","url":"https://www.academia.edu/Documents/in/Coronary_heart_disease?f_ri=234187"},{"id":402431,"name":"Success Rate","url":"https://www.academia.edu/Documents/in/Success_Rate?f_ri=234187"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1?f_ri=234187"},{"id":1312754,"name":"Prospective Study","url":"https://www.academia.edu/Documents/in/Prospective_Study?f_ri=234187"},{"id":1863718,"name":"The American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7462791" data-work_id="7462791" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7462791/Fecal_calprotectin_and_lactoferrin_for_the_prediction_of_inflammatory_bowel_disease_relapse">Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background:The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_7462791" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background:The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study.The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study.Methods:The prospective multicenter study included CD and UC patients who had been in clinical remission for 6 months. At baseline, patients provided a single stool sample for calprotectin and lactoferrin determination. Follow-up was 12 months in patients showing no relapse and until activity flare in relapsing patients.The prospective multicenter study included CD and UC patients who had been in clinical remission for 6 months. At baseline, patients provided a single stool sample for calprotectin and lactoferrin determination. Follow-up was 12 months in patients showing no relapse and until activity flare in relapsing patients.Results:In all, 163 patients (89 CD, 74 UC) were included. Twenty-six patients (16%) relapsed during follow-up. Calprotectin concentrations in patients who suffered a relapse were higher than in nonrelapsing patients (239 ± 150 versus 136 ± 158 μg/g; P < 0.001). Relapse risk was higher in patients having high (>150 μg/g) calprotectin concentrations (30% versus 7.8%; P < 0.001) or positive lactoferrin (25% versus 10%; P < 0.05). Fecal calprotectin (>150 μg/g) sensitivity and specificity to predict relapse were 69% and 69%, respectively. Corresponding values for lactoferrin were 62% and 65%, respectively. The area under the receiver operating characteristic curve to predict relapse using calprotectin determination was 0.73 (0.69 for UC and 0.77 for CD). Better results were obtained when only colonic CD disease or only relapses during the first 3 months were considered (100% sensitivity). High fecal calprotectin levels or lactoferrin positivity was associated with clinical relapse in Kaplan–Meier survival analysis, and both fecal tests were associated with relapse in the multivariate analysis.In all, 163 patients (89 CD, 74 UC) were included. Twenty-six patients (16%) relapsed during follow-up. Calprotectin concentrations in patients who suffered a relapse were higher than in nonrelapsing patients (239 ± 150 versus 136 ± 158 μg/g; P < 0.001). Relapse risk was higher in patients having high (>150 μg/g) calprotectin concentrations (30% versus 7.8%; P < 0.001) or positive lactoferrin (25% versus 10%; P < 0.05). Fecal calprotectin (>150 μg/g) sensitivity and specificity to predict relapse were 69% and 69%, respectively. Corresponding values for lactoferrin were 62% and 65%, respectively. The area under the receiver operating characteristic curve to predict relapse using calprotectin determination was 0.73 (0.69 for UC and 0.77 for CD). Better results were obtained when only colonic CD disease or only relapses during the first 3 months were considered (100% sensitivity). High fecal calprotectin levels or lactoferrin positivity was associated with clinical relapse in Kaplan–Meier survival analysis, and both fecal tests were associated with relapse in the multivariate analysis.Conclusions:Fecal calprotectin and lactoferrin determination may be useful in predicting impending clinical relapse—especially during the following 3 months—in both CD and UC patients. (Inflamm Bowel Dis 2009)Fecal calprotectin and lactoferrin determination may be useful in predicting impending clinical relapse—especially during the following 3 months—in both CD and UC patients. (Inflamm Bowel Dis 2009)</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7462791" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b29ef60c0649daee46fc0e187fb41bf1" rel="nofollow" data-download="{"attachment_id":48463132,"asset_id":7462791,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48463132/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="13290715" href="https://ecosur.academia.edu/IsabelVera">Isabel Vera</a><script data-card-contents-for-user="13290715" type="text/json">{"id":13290715,"first_name":"Isabel","last_name":"Vera","domain_name":"ecosur","page_name":"IsabelVera","display_name":"Isabel Vera","profile_url":"https://ecosur.academia.edu/IsabelVera?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_7462791 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="7462791"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 7462791, container: ".js-paper-rank-work_7462791", }); 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$(".js-view-count[data-work-id=7462791]").text(description); $(".js-view-count-work_7462791").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_7462791").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7462791"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">12</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="59366" href="https://www.academia.edu/Documents/in/Inflammatory_Bowel_Disease">Inflammatory Bowel Disease</a>, <script data-card-contents-for-ri="59366" type="text/json">{"id":59366,"name":"Inflammatory Bowel Disease","url":"https://www.academia.edu/Documents/in/Inflammatory_Bowel_Disease?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="62112" href="https://www.academia.edu/Documents/in/Prospective_studies">Prospective studies</a>, <script data-card-contents-for-ri="62112" type="text/json">{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="83691" href="https://www.academia.edu/Documents/in/Ulcerative_colitis">Ulcerative colitis</a>, <script data-card-contents-for-ri="83691" type="text/json">{"id":83691,"name":"Ulcerative colitis","url":"https://www.academia.edu/Documents/in/Ulcerative_colitis?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a><script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7462791]'), work: {"id":7462791,"title":"Fecal calprotectin and lactoferrin for the prediction of inflammatory bowel disease relapse","created_at":"2014-06-25T17:13:23.504-07:00","url":"https://www.academia.edu/7462791/Fecal_calprotectin_and_lactoferrin_for_the_prediction_of_inflammatory_bowel_disease_relapse?f_ri=234187","dom_id":"work_7462791","summary":"Background:The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study.The purpose of the study was to determine the role of fecal calprotectin and lactoferrin in the prediction of inflammatory bowel disease relapses, both in patients with ulcerative colitis (UC) and Crohn's disease (CD), in a large, long-term, follow-up study.Methods:The prospective multicenter study included CD and UC patients who had been in clinical remission for 6 months. At baseline, patients provided a single stool sample for calprotectin and lactoferrin determination. Follow-up was 12 months in patients showing no relapse and until activity flare in relapsing patients.The prospective multicenter study included CD and UC patients who had been in clinical remission for 6 months. At baseline, patients provided a single stool sample for calprotectin and lactoferrin determination. Follow-up was 12 months in patients showing no relapse and until activity flare in relapsing patients.Results:In all, 163 patients (89 CD, 74 UC) were included. Twenty-six patients (16%) relapsed during follow-up. Calprotectin concentrations in patients who suffered a relapse were higher than in nonrelapsing patients (239 ± 150 versus 136 ± 158 μg/g; P \u003c 0.001). Relapse risk was higher in patients having high (\u003e150 μg/g) calprotectin concentrations (30% versus 7.8%; P \u003c 0.001) or positive lactoferrin (25% versus 10%; P \u003c 0.05). Fecal calprotectin (\u003e150 μg/g) sensitivity and specificity to predict relapse were 69% and 69%, respectively. Corresponding values for lactoferrin were 62% and 65%, respectively. The area under the receiver operating characteristic curve to predict relapse using calprotectin determination was 0.73 (0.69 for UC and 0.77 for CD). Better results were obtained when only colonic CD disease or only relapses during the first 3 months were considered (100% sensitivity). High fecal calprotectin levels or lactoferrin positivity was associated with clinical relapse in Kaplan–Meier survival analysis, and both fecal tests were associated with relapse in the multivariate analysis.In all, 163 patients (89 CD, 74 UC) were included. Twenty-six patients (16%) relapsed during follow-up. Calprotectin concentrations in patients who suffered a relapse were higher than in nonrelapsing patients (239 ± 150 versus 136 ± 158 μg/g; P \u003c 0.001). Relapse risk was higher in patients having high (\u003e150 μg/g) calprotectin concentrations (30% versus 7.8%; P \u003c 0.001) or positive lactoferrin (25% versus 10%; P \u003c 0.05). Fecal calprotectin (\u003e150 μg/g) sensitivity and specificity to predict relapse were 69% and 69%, respectively. Corresponding values for lactoferrin were 62% and 65%, respectively. The area under the receiver operating characteristic curve to predict relapse using calprotectin determination was 0.73 (0.69 for UC and 0.77 for CD). Better results were obtained when only colonic CD disease or only relapses during the first 3 months were considered (100% sensitivity). High fecal calprotectin levels or lactoferrin positivity was associated with clinical relapse in Kaplan–Meier survival analysis, and both fecal tests were associated with relapse in the multivariate analysis.Conclusions:Fecal calprotectin and lactoferrin determination may be useful in predicting impending clinical relapse—especially during the following 3 months—in both CD and UC patients. (Inflamm Bowel Dis 2009)Fecal calprotectin and lactoferrin determination may be useful in predicting impending clinical relapse—especially during the following 3 months—in both CD and UC patients. (Inflamm Bowel Dis 2009)","downloadable_attachments":[{"id":48463132,"asset_id":7462791,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":13290715,"first_name":"Isabel","last_name":"Vera","domain_name":"ecosur","page_name":"IsabelVera","display_name":"Isabel Vera","profile_url":"https://ecosur.academia.edu/IsabelVera?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":59366,"name":"Inflammatory Bowel Disease","url":"https://www.academia.edu/Documents/in/Inflammatory_Bowel_Disease?f_ri=234187","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=234187","nofollow":false},{"id":83691,"name":"Ulcerative colitis","url":"https://www.academia.edu/Documents/in/Ulcerative_colitis?f_ri=234187","nofollow":false},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=234187","nofollow":false},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=234187"},{"id":469102,"name":"Feces","url":"https://www.academia.edu/Documents/in/Feces?f_ri=234187"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=234187"},{"id":568482,"name":"Biological markers","url":"https://www.academia.edu/Documents/in/Biological_markers?f_ri=234187"},{"id":1351088,"name":"Crohn Disease","url":"https://www.academia.edu/Documents/in/Crohn_Disease?f_ri=234187"},{"id":1810568,"name":"Inflammatory Bowel Diseases","url":"https://www.academia.edu/Documents/in/Inflammatory_Bowel_Diseases?f_ri=234187"},{"id":1819399,"name":"Case Control Studies","url":"https://www.academia.edu/Documents/in/Case_Control_Studies?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_27917488" data-work_id="27917488" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/27917488/Salvage_treatment_for_children_with_refractory_first_or_second_relapse_of_acute_myeloid_leukaemia_with_gemtuzumab_ozogamicin_results_of_a_phase_II_study">Salvage treatment for children with refractory first or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a 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class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="52303356" href="https://uni-due.academia.edu/DirkReinhardt">Dirk Reinhardt</a><script data-card-contents-for-user="52303356" type="text/json">{"id":52303356,"first_name":"Dirk","last_name":"Reinhardt","domain_name":"uni-due","page_name":"DirkReinhardt","display_name":"Dirk Reinhardt","profile_url":"https://uni-due.academia.edu/DirkReinhardt?f_ri=234187","photo":"https://0.academia-photos.com/52303356/16936390/17150084/s65_dirk.reinhardt.jpg"}</script></span></span></li><li class="js-paper-rank-work_27917488 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="27917488"><i class="u-m1x fa fa-bar-chart"></i><strong 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data-card-contents-for-ri="7324" type="text/json">{"id":7324,"name":"British","url":"https://www.academia.edu/Documents/in/British?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a>, <script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="59057" href="https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia">Acute Myeloid Leukemia</a><script data-card-contents-for-ri="59057" type="text/json">{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=27917488]'), work: {"id":27917488,"title":"Salvage treatment for children with refractory first or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study","created_at":"2016-08-20T22:56:19.674-07:00","url":"https://www.academia.edu/27917488/Salvage_treatment_for_children_with_refractory_first_or_second_relapse_of_acute_myeloid_leukaemia_with_gemtuzumab_ozogamicin_results_of_a_phase_II_study?f_ri=234187","dom_id":"work_27917488","summary":null,"downloadable_attachments":[{"id":48211605,"asset_id":27917488,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":52303356,"first_name":"Dirk","last_name":"Reinhardt","domain_name":"uni-due","page_name":"DirkReinhardt","display_name":"Dirk Reinhardt","profile_url":"https://uni-due.academia.edu/DirkReinhardt?f_ri=234187","photo":"https://0.academia-photos.com/52303356/16936390/17150084/s65_dirk.reinhardt.jpg"}],"research_interests":[{"id":7324,"name":"British","url":"https://www.academia.edu/Documents/in/British?f_ri=234187","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=234187","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false},{"id":59057,"name":"Acute Myeloid Leukemia","url":"https://www.academia.edu/Documents/in/Acute_Myeloid_Leukemia?f_ri=234187","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=234187"},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=234187"},{"id":147196,"name":"Monoclonal Antibodies","url":"https://www.academia.edu/Documents/in/Monoclonal_Antibodies?f_ri=234187"},{"id":149186,"name":"Aminoglycosides","url":"https://www.academia.edu/Documents/in/Aminoglycosides?f_ri=234187"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187"},{"id":1212103,"name":"Antineoplastic Agents","url":"https://www.academia.edu/Documents/in/Antineoplastic_Agents?f_ri=234187"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_13844758 coauthored" data-work_id="13844758" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/13844758/Volvulus_of_the_sigmoid_colon">Volvulus of the sigmoid colon</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/13844758" 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The purpose of this investigation was to assess the adjuvant... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_23399347" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Electrochemotherapy (ECT) is a novel anticancer therapy that combines the delivery of trains of appropriate waveforms with the local administration of chemotherapy agents. The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT). Twenty-eight privately-owned dogs with incompletely removed MCT were treated with intralesional bleomycin (1.5 IU/cm2) followed by the application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50 + 50 micros duration, 1 Hz frequency). The overall response rate was 85% with a mean estimated time to recurrence of 52.76 +/- 6.5 months (range: 39.99 to 65.54 months, 95% CI). At the time of writing this report, the median survival time was not reached. Three dogs died of metastatic disease that they developed at the same time of local recurrence, one developed multiple cutaneous nodules at different locations and one with recurrence was re-treated and is currently disease...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/23399347" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="a98dabf21d410d9343b5e38b7ddae8c5" rel="nofollow" data-download="{"attachment_id":43847062,"asset_id":23399347,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/43847062/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="33983376" href="https://unina2.academia.edu/AlfonsoBaldi">Alfonso Baldi</a><script data-card-contents-for-user="33983376" type="text/json">{"id":33983376,"first_name":"Alfonso","last_name":"Baldi","domain_name":"unina2","page_name":"AlfonsoBaldi","display_name":"Alfonso Baldi","profile_url":"https://unina2.academia.edu/AlfonsoBaldi?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_23399347 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="23399347"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 23399347, container: ".js-paper-rank-work_23399347", }); 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The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT). Twenty-eight privately-owned dogs with incompletely removed MCT were treated with intralesional bleomycin (1.5 IU/cm2) followed by the application of trains of biphasic pulses (8 pulses, 1300 V/cm, 50 + 50 micros duration, 1 Hz frequency). The overall response rate was 85% with a mean estimated time to recurrence of 52.76 +/- 6.5 months (range: 39.99 to 65.54 months, 95% CI). At the time of writing this report, the median survival time was not reached. Three dogs died of metastatic disease that they developed at the same time of local recurrence, one developed multiple cutaneous nodules at different locations and one with recurrence was re-treated and is currently disease...","downloadable_attachments":[{"id":43847062,"asset_id":23399347,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":33983376,"first_name":"Alfonso","last_name":"Baldi","domain_name":"unina2","page_name":"AlfonsoBaldi","display_name":"Alfonso Baldi","profile_url":"https://unina2.academia.edu/AlfonsoBaldi?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":12426,"name":"Treatment 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u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/72879776/Treatment_of_chronic_or_recurrent_proximal_suspensory_desmitis_using_radial_pressure_wave_therapy_in_the_horse">Treatment of chronic or recurrent proximal suspensory desmitis using radial pressure wave therapy in the horse</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Summary Reasons for performing study: Proximal suspensory desmitis (PSD) is diagnosed with increasing frequency in horses and radial pressure wave therapy (RPWT) is a widely used therapy for painful orthopaedic conditions in man and dogs.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_72879776" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Summary Reasons for performing study: Proximal suspensory desmitis (PSD) is diagnosed with increasing frequency in horses and radial pressure wave therapy (RPWT) is a widely used therapy for painful orthopaedic conditions in man and dogs. There are, however, few ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/72879776" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f33a5393d9e3aeba71d3d890258e791c" rel="nofollow" data-download="{"attachment_id":81628168,"asset_id":72879776,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/81628168/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="129480547" href="https://vetagro-sup.academia.edu/MichaelSchramme">Michael Schramme</a><script data-card-contents-for-user="129480547" type="text/json">{"id":129480547,"first_name":"Michael","last_name":"Schramme","domain_name":"vetagro-sup","page_name":"MichaelSchramme","display_name":"Michael Schramme","profile_url":"https://vetagro-sup.academia.edu/MichaelSchramme?f_ri=234187","photo":"https://0.academia-photos.com/129480547/41396879/33566912/s65_michael.schramme.jpg"}</script></span></span></li><li class="js-paper-rank-work_72879776 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="72879776"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 72879776, container: ".js-paper-rank-work_72879776", }); 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$(".js-view-count[data-work-id=72879776]").text(description); $(".js-view-count-work_72879776").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_72879776").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="72879776"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">10</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9334" href="https://www.academia.edu/Documents/in/Inflammation">Inflammation</a>, <script data-card-contents-for-ri="9334" type="text/json">{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="47884" href="https://www.academia.edu/Documents/in/Biological_Sciences">Biological Sciences</a><script data-card-contents-for-ri="47884" type="text/json">{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=72879776]'), work: {"id":72879776,"title":"Treatment of chronic or recurrent proximal suspensory desmitis using radial pressure wave therapy in the horse","created_at":"2022-03-03T00:31:14.285-08:00","url":"https://www.academia.edu/72879776/Treatment_of_chronic_or_recurrent_proximal_suspensory_desmitis_using_radial_pressure_wave_therapy_in_the_horse?f_ri=234187","dom_id":"work_72879776","summary":"Summary Reasons for performing study: Proximal suspensory desmitis (PSD) is diagnosed with increasing frequency in horses and radial pressure wave therapy (RPWT) is a widely used therapy for painful orthopaedic conditions in man and dogs. There are, however, few ...","downloadable_attachments":[{"id":81628168,"asset_id":72879776,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":129480547,"first_name":"Michael","last_name":"Schramme","domain_name":"vetagro-sup","page_name":"MichaelSchramme","display_name":"Michael Schramme","profile_url":"https://vetagro-sup.academia.edu/MichaelSchramme?f_ri=234187","photo":"https://0.academia-photos.com/129480547/41396879/33566912/s65_michael.schramme.jpg"}],"research_interests":[{"id":9334,"name":"Inflammation","url":"https://www.academia.edu/Documents/in/Inflammation?f_ri=234187","nofollow":false},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=234187","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=234187","nofollow":false},{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences?f_ri=234187","nofollow":false},{"id":97269,"name":"Chronic Disease","url":"https://www.academia.edu/Documents/in/Chronic_Disease?f_ri=234187"},{"id":168196,"name":"Horses","url":"https://www.academia.edu/Documents/in/Horses?f_ri=234187"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=234187"},{"id":990519,"name":"Ligaments","url":"https://www.academia.edu/Documents/in/Ligaments?f_ri=234187"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_66788900" data-work_id="66788900" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/66788900/Recurrent_symptomatic_aortic_sac_seroma_after_open_abdominal_aortic_aneurysm_repair">Recurrent symptomatic aortic sac seroma after open abdominal aortic aneurysm repair</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/66788900" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b8b940e6cc77c0a3d21e557d3ccd921b" rel="nofollow" data-download="{"attachment_id":77845968,"asset_id":66788900,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/77845968/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="45950968" href="https://independent.academia.edu/RobertCuff">Robert Cuff</a><script data-card-contents-for-user="45950968" type="text/json">{"id":45950968,"first_name":"Robert","last_name":"Cuff","domain_name":"independent","page_name":"RobertCuff","display_name":"Robert Cuff","profile_url":"https://independent.academia.edu/RobertCuff?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_66788900 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="66788900"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 66788900, container: ".js-paper-rank-work_66788900", }); });</script></li><li class="js-percentile-work_66788900 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 66788900; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_66788900"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_66788900 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="66788900"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 66788900; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=66788900]").text(description); $(".js-view-count-work_66788900").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_66788900").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="66788900"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="25398" href="https://www.academia.edu/Documents/in/Vascular_Surgery">Vascular Surgery</a>, <script data-card-contents-for-ri="25398" type="text/json">{"id":25398,"name":"Vascular Surgery","url":"https://www.academia.edu/Documents/in/Vascular_Surgery?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a>, <script data-card-contents-for-ri="26327" type="text/json">{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="234187" href="https://www.academia.edu/Documents/in/Recurrence">Recurrence</a>, <script data-card-contents-for-ri="234187" type="text/json">{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="289271" href="https://www.academia.edu/Documents/in/Aged">Aged</a><script data-card-contents-for-ri="289271" type="text/json">{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=66788900]'), work: {"id":66788900,"title":"Recurrent symptomatic aortic sac seroma after open abdominal aortic aneurysm repair","created_at":"2022-01-01T07:08:51.335-08:00","url":"https://www.academia.edu/66788900/Recurrent_symptomatic_aortic_sac_seroma_after_open_abdominal_aortic_aneurysm_repair?f_ri=234187","dom_id":"work_66788900","summary":null,"downloadable_attachments":[{"id":77845968,"asset_id":66788900,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":45950968,"first_name":"Robert","last_name":"Cuff","domain_name":"independent","page_name":"RobertCuff","display_name":"Robert Cuff","profile_url":"https://independent.academia.edu/RobertCuff?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":25398,"name":"Vascular Surgery","url":"https://www.academia.edu/Documents/in/Vascular_Surgery?f_ri=234187","nofollow":false},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine?f_ri=234187","nofollow":false},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187","nofollow":false},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=234187","nofollow":false},{"id":1305425,"name":"Abdominal Aortic Aneurysm","url":"https://www.academia.edu/Documents/in/Abdominal_Aortic_Aneurysm?f_ri=234187"},{"id":2067627,"name":"Seroma","url":"https://www.academia.edu/Documents/in/Seroma?f_ri=234187"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_63401242" data-work_id="63401242" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/63401242/Survival_of_women_with_locally_advanced_breast_cancer_at_a_teaching_hospital_in_Lahore">Survival of women with locally advanced breast cancer at a teaching hospital in Lahore</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_63401242" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively over 9 years with Stage III breast cancer were evaluated for age, socio-economic status (SES), tumour size and grade, number of involved lymph nodes, stage III sub-categories, estrogen and progesterone receptor (ER/PR) status, treatment profiles and responses, and sites of relapse. EFS and OS at 5 and 10 years were calculated. Median age was 45 years. Poorly differentiated tumours were found in 127 patients, while 128 had larger tumours (T3 and T4). Eighty women had extensive nodal involvement (N2 and N3), and 86 had Stage IIIA tumours. Chemotherapy was given to 44 patients before surgery and one of these patients achieved pathological complete response. At 5 and 10 years, EFS was 25% and 7%, and OS was 52% and 31%, respectively. By Cox regression a...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/63401242" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1e3db193cc4855b5a526db0c3a54f77f" rel="nofollow" data-download="{"attachment_id":75843954,"asset_id":63401242,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75843954/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="34372370" href="https://independent.academia.edu/DrMAsifSaeed">Dr. M. Asif Saeed</a><script data-card-contents-for-user="34372370" type="text/json">{"id":34372370,"first_name":"Dr. M. Asif","last_name":"Saeed","domain_name":"independent","page_name":"DrMAsifSaeed","display_name":"Dr. M. Asif Saeed","profile_url":"https://independent.academia.edu/DrMAsifSaeed?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_63401242 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="63401242"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 63401242, container: ".js-paper-rank-work_63401242", }); });</script></li><li class="js-percentile-work_63401242 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 63401242; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_63401242"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_63401242 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="63401242"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 63401242; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=63401242]").text(description); $(".js-view-count-work_63401242").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_63401242").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="63401242"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="2066" href="https://www.academia.edu/Documents/in/Research_Design">Research Design</a>, <script data-card-contents-for-ri="2066" type="text/json">{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="6802" href="https://www.academia.edu/Documents/in/Breast_Cancer">Breast Cancer</a>, <script data-card-contents-for-ri="6802" type="text/json">{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="7361" href="https://www.academia.edu/Documents/in/Pakistan">Pakistan</a>, <script data-card-contents-for-ri="7361" type="text/json">{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="10610" href="https://www.academia.edu/Documents/in/Survival_Analysis">Survival Analysis</a><script data-card-contents-for-ri="10610" type="text/json">{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=63401242]'), work: {"id":63401242,"title":"Survival of women with locally advanced breast cancer at a teaching hospital in Lahore","created_at":"2021-12-06T22:09:29.531-08:00","url":"https://www.academia.edu/63401242/Survival_of_women_with_locally_advanced_breast_cancer_at_a_teaching_hospital_in_Lahore?f_ri=234187","dom_id":"work_63401242","summary":"To correlate the clinical features of women presenting with locally advanced breast cancer with event-free survival (EFS) and overall survival (OS) and to evaluate the patterns of relapse. A total of 200 patients presenting consecutively over 9 years with Stage III breast cancer were evaluated for age, socio-economic status (SES), tumour size and grade, number of involved lymph nodes, stage III sub-categories, estrogen and progesterone receptor (ER/PR) status, treatment profiles and responses, and sites of relapse. EFS and OS at 5 and 10 years were calculated. Median age was 45 years. Poorly differentiated tumours were found in 127 patients, while 128 had larger tumours (T3 and T4). Eighty women had extensive nodal involvement (N2 and N3), and 86 had Stage IIIA tumours. Chemotherapy was given to 44 patients before surgery and one of these patients achieved pathological complete response. At 5 and 10 years, EFS was 25% and 7%, and OS was 52% and 31%, respectively. By Cox regression a...","downloadable_attachments":[{"id":75843954,"asset_id":63401242,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":34372370,"first_name":"Dr. M. Asif","last_name":"Saeed","domain_name":"independent","page_name":"DrMAsifSaeed","display_name":"Dr. M. Asif Saeed","profile_url":"https://independent.academia.edu/DrMAsifSaeed?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":2066,"name":"Research Design","url":"https://www.academia.edu/Documents/in/Research_Design?f_ri=234187","nofollow":false},{"id":6802,"name":"Breast Cancer","url":"https://www.academia.edu/Documents/in/Breast_Cancer?f_ri=234187","nofollow":false},{"id":7361,"name":"Pakistan","url":"https://www.academia.edu/Documents/in/Pakistan?f_ri=234187","nofollow":false},{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis?f_ri=234187","nofollow":false},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=234187"},{"id":70854,"name":"Developing Country","url":"https://www.academia.edu/Documents/in/Developing_Country?f_ri=234187"},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=234187"},{"id":158839,"name":"Breast Cancer Research","url":"https://www.academia.edu/Documents/in/Breast_Cancer_Research?f_ri=234187"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=234187"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate?f_ri=234187"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis?f_ri=234187"},{"id":2463779,"name":"Combined Modality Therapy","url":"https://www.academia.edu/Documents/in/Combined_Modality_Therapy?f_ri=234187"},{"id":2847999,"name":"Breast Neoplasms","url":"https://www.academia.edu/Documents/in/Breast_Neoplasms?f_ri=234187"},{"id":3082379,"name":"Disease Free Survival","url":"https://www.academia.edu/Documents/in/Disease_Free_Survival?f_ri=234187"},{"id":3118074,"name":"Neoplasm staging","url":"https://www.academia.edu/Documents/in/Neoplasm_staging?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_62204938" data-work_id="62204938" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/62204938/New_aspects_in_the_clinical_course_of_pityriasis_versicolor">New aspects in the clinical course of pityriasis versicolor</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pytiriasis versicolor is an infectious disease caused by several Malassezia species which has a tendency to become relapsing or chronic. This study was conducted in an attempt to investigate the clinical course of pityriasis versicolor... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_62204938" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pytiriasis versicolor is an infectious disease caused by several Malassezia species which has a tendency to become relapsing or chronic. This study was conducted in an attempt to investigate the clinical course of pityriasis versicolor with regard to the number of relapses after a 12-month therapy and correlate this number with isolates of Malassezia species. 102 patients with clinical and laboratory diagnosis of pityriasis versicolor were monitored for 12 months to investigate the number of relapsing episodes of the disease. After appropriate treatment, pityriasis versicolor presented three types of clinical course: pityriasis versicolor without relapsing episodes (32.35%), relapsing pityriasis versicolor with one to four relapsing episodes (52.94% ) due to associated predisposing factors, and chronic pityriasis versicolor with more than four relapsing episodes (14.70%) with no relation to predisposing factors. The clinical course of pityriasis versicolor varied according to the nu...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/62204938" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c00b8c9823e0c0b8122093ca3dcf5b88" rel="nofollow" data-download="{"attachment_id":75038527,"asset_id":62204938,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/75038527/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="96246093" href="https://independent.academia.edu/VFRAMIL">VALERIA FRAMIL</a><script data-card-contents-for-user="96246093" type="text/json">{"id":96246093,"first_name":"VALERIA","last_name":"FRAMIL","domain_name":"independent","page_name":"VFRAMIL","display_name":"VALERIA FRAMIL","profile_url":"https://independent.academia.edu/VFRAMIL?f_ri=234187","photo":"https://0.academia-photos.com/96246093/25834715/24503286/s65_valeria.framil.jpg"}</script></span></span></li><li class="js-paper-rank-work_62204938 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="62204938"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 62204938, container: ".js-paper-rank-work_62204938", }); 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This study was conducted in an attempt to investigate the clinical course of pityriasis versicolor with regard to the number of relapses after a 12-month therapy and correlate this number with isolates of Malassezia species. 102 patients with clinical and laboratory diagnosis of pityriasis versicolor were monitored for 12 months to investigate the number of relapsing episodes of the disease. After appropriate treatment, pityriasis versicolor presented three types of clinical course: pityriasis versicolor without relapsing episodes (32.35%), relapsing pityriasis versicolor with one to four relapsing episodes (52.94% ) due to associated predisposing factors, and chronic pityriasis versicolor with more than four relapsing episodes (14.70%) with no relation to predisposing factors. The clinical course of pityriasis versicolor varied according to the nu...","downloadable_attachments":[{"id":75038527,"asset_id":62204938,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":96246093,"first_name":"VALERIA","last_name":"FRAMIL","domain_name":"independent","page_name":"VFRAMIL","display_name":"VALERIA FRAMIL","profile_url":"https://independent.academia.edu/VFRAMIL?f_ri=234187","photo":"https://0.academia-photos.com/96246093/25834715/24503286/s65_valeria.framil.jpg"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=234187","nofollow":false},{"id":64933,"name":"Child","url":"https://www.academia.edu/Documents/in/Child?f_ri=234187","nofollow":false},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult?f_ri=234187","nofollow":false},{"id":134346,"name":"Infant","url":"https://www.academia.edu/Documents/in/Infant?f_ri=234187"},{"id":161701,"name":"Malassezia","url":"https://www.academia.edu/Documents/in/Malassezia?f_ri=234187"},{"id":215552,"name":"Ketoconazole","url":"https://www.academia.edu/Documents/in/Ketoconazole?f_ri=234187"},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant?f_ri=234187"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged?f_ri=234187"},{"id":552209,"name":"Antifungal Agents","url":"https://www.academia.edu/Documents/in/Antifungal_Agents?f_ri=234187"},{"id":2489700,"name":"Child preschool","url":"https://www.academia.edu/Documents/in/Child_preschool?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_61366612" data-work_id="61366612" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/61366612/The_Prognosis_Of_Adult_Burkitts_Cell_Leukemia_In_Real_Life_Clinical_Practice">The Prognosis Of Adult Burkitt's Cell Leukemia In Real-Life Clinical Practice</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Many studies reported an improved prognosis in the patients with Burkitt&#39;s lymphoma obviating the need of stem cell transplantation. However, prognosis of the advanced disease (i.e. Burkitt&#39;s cell leukemia) has not been reported... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_61366612" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Many studies reported an improved prognosis in the patients with Burkitt&#39;s lymphoma obviating the need of stem cell transplantation. However, prognosis of the advanced disease (i.e. Burkitt&#39;s cell leukemia) has not been reported with current treatment modalities except for a few prospective trials. The aim of this study is to compare the prognoses of the Burkitt&#39;s cell leukemia (BL) patients with similarly treated and not transplanted other types of acute lymphoblastic leukemia (ALL) patients and with ALL cases that underwent allogeneic stem cell transplantation (ASCT) in their first remissions. In this retrospective analysis, BL patients aged between 16 and 63 who admitted between 2000 and 2014 to Hacettepe or Gazi University Hospitals and treated with intensive therapies aiming cure were included in the study. All ALL patients who were treated with a similar protocol not including transplantation during the same period (NTxALL group) and all ALL patients who underwent ...</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/61366612" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="3c1eb0ea01c45950e31ef9944c9a80f9" rel="nofollow" data-download="{"attachment_id":74418756,"asset_id":61366612,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/74418756/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="97438519" href="https://hacettepe.academia.edu/sezginetg%C3%BCl">sezgin etgül</a><script data-card-contents-for-user="97438519" type="text/json">{"id":97438519,"first_name":"sezgin","last_name":"etgül","domain_name":"hacettepe","page_name":"sezginetgül","display_name":"sezgin etgül","profile_url":"https://hacettepe.academia.edu/sezginetg%C3%BCl?f_ri=234187","photo":"https://0.academia-photos.com/97438519/22036525/21281055/s65_sezgin.etg_l.jpg"}</script></span></span></li><li class="js-paper-rank-work_61366612 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="61366612"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 61366612, container: ".js-paper-rank-work_61366612", }); 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However, prognosis of the advanced disease (i.e. Burkitt\u0026#39;s cell leukemia) has not been reported with current treatment modalities except for a few prospective trials. The aim of this study is to compare the prognoses of the Burkitt\u0026#39;s cell leukemia (BL) patients with similarly treated and not transplanted other types of acute lymphoblastic leukemia (ALL) patients and with ALL cases that underwent allogeneic stem cell transplantation (ASCT) in their first remissions. In this retrospective analysis, BL patients aged between 16 and 63 who admitted between 2000 and 2014 to Hacettepe or Gazi University Hospitals and treated with intensive therapies aiming cure were included in the study. 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class="clearfix u-pv7x u-mb0x js-work-card work_30155458" data-work_id="30155458" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/30155458/The_Effect_of_Tranexamic_Acid_on_Secondary_Haemorrhage_After_Traumatic_Hyphaema">The Effect of Tranexamic Acid on Secondary Haemorrhage After Traumatic Hyphaema</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/30155458" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div 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Dalsgaard","profile_url":"https://independent.academia.edu/CarlJohanDalsgaard?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false},{"id":62112,"name":"Prospective studies","url":"https://www.academia.edu/Documents/in/Prospective_studies?f_ri=234187","nofollow":false},{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=234187","nofollow":false},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187","nofollow":false},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences?f_ri=234187"},{"id":359001,"name":"Optometry and Ophthalmology","url":"https://www.academia.edu/Documents/in/Optometry_and_Ophthalmology?f_ri=234187"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_6427851" data-work_id="6427851" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/6427851/Apolipoprotein_E_genotype_does_not_associate_with_disease_severity_measured_by_Multiple_Sclerosis_Severity_Score">Apolipoprotein E genotype does not associate with disease severity measured by Multiple Sclerosis Severity Score</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objectives – During the last years, the association between apolipoprotein E (APOE) polymorphism and disease severity in multiple sclerosis (MS) has been studied with conflicting results. As a result of a considerable individual... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6427851" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objectives – During the last years, the association between apolipoprotein E (APOE) polymorphism and disease severity in multiple sclerosis (MS) has been studied with conflicting results. As a result of a considerable individual variation in the clinical course of MS, there is no consensus method for measuring progression using single assessments of disability. Recently, Multiple Sclerosis Severity Score (MSSS) method has been proposed for comparing disease progression using single data. We evaluate in our population if there is any correlation between APOE genotype and severity according to MSSS.Methods – We studied 82 patients followed up in our Neurology Unit throughout the year 2005, diagnosed with MS, and with disease duration of at least 2 years. We collected data concerning demographic and clinical variables including age of onset, disease duration, Expanded Disability Status Scale (EDSS) score and the total number of relapses. When reached, we determined the latency to EDSS scores of 4.0 and 6.0. We calculated progression index (PI) and relapse rate (RR). We ascertained MSSS for our patients in the global MSSS table.Results – We found four patients heterozygous for the E2 allele and 16 for the E4 allele. No patient was homozygous for E2 or E4. RR (P = 0.017 with 95% CI: 0.005–0.57) and PI (P = 0.016 with 95% CI: 0.004–0.38) were significantly lower in E4 carriers. MSSS scores were not associated with carriership of E2 or E4.Conclusion – Our results show no effect of the APOE genotype on the severity of MS measured by MSSS, as a recently published meta-analysis has noticed. So, our data do not support a role for APOE in MS severity, in spite of the seeming influence shown using other measures such as PI. MSSS is probably the best method to measure severity with a single measure of disability and should be used more frequently when performing genetic research.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6427851" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="0c3b50d9d1eae1f9cb00ebd390477711" rel="nofollow" data-download="{"attachment_id":48871904,"asset_id":6427851,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/48871904/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="10133075" href="https://independent.academia.edu/JesusPeralta2">Jesus Peralta</a><script data-card-contents-for-user="10133075" type="text/json">{"id":10133075,"first_name":"Jesus","last_name":"Peralta","domain_name":"independent","page_name":"JesusPeralta2","display_name":"Jesus Peralta","profile_url":"https://independent.academia.edu/JesusPeralta2?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_6427851 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6427851"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6427851, container: ".js-paper-rank-work_6427851", }); 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$(".js-view-count[data-work-id=6427851]").text(description); $(".js-view-count-work_6427851").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_6427851").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="6427851"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">16</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="3097" href="https://www.academia.edu/Documents/in/Multiple_sclerosis">Multiple sclerosis</a>, <script data-card-contents-for-ri="3097" type="text/json">{"id":3097,"name":"Multiple sclerosis","url":"https://www.academia.edu/Documents/in/Multiple_sclerosis?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="73153" href="https://www.academia.edu/Documents/in/Genetic_Testing">Genetic Testing</a>, <script data-card-contents-for-ri="73153" type="text/json">{"id":73153,"name":"Genetic Testing","url":"https://www.academia.edu/Documents/in/Genetic_Testing?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="137946" href="https://www.academia.edu/Documents/in/Disease_Severity">Disease Severity</a><script data-card-contents-for-ri="137946" type="text/json">{"id":137946,"name":"Disease Severity","url":"https://www.academia.edu/Documents/in/Disease_Severity?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=6427851]'), work: {"id":6427851,"title":"Apolipoprotein E genotype does not associate with disease severity measured by Multiple Sclerosis Severity Score","created_at":"2014-03-15T23:32:52.928-07:00","url":"https://www.academia.edu/6427851/Apolipoprotein_E_genotype_does_not_associate_with_disease_severity_measured_by_Multiple_Sclerosis_Severity_Score?f_ri=234187","dom_id":"work_6427851","summary":"Objectives – During the last years, the association between apolipoprotein E (APOE) polymorphism and disease severity in multiple sclerosis (MS) has been studied with conflicting results. As a result of a considerable individual variation in the clinical course of MS, there is no consensus method for measuring progression using single assessments of disability. Recently, Multiple Sclerosis Severity Score (MSSS) method has been proposed for comparing disease progression using single data. We evaluate in our population if there is any correlation between APOE genotype and severity according to MSSS.Methods – We studied 82 patients followed up in our Neurology Unit throughout the year 2005, diagnosed with MS, and with disease duration of at least 2 years. We collected data concerning demographic and clinical variables including age of onset, disease duration, Expanded Disability Status Scale (EDSS) score and the total number of relapses. When reached, we determined the latency to EDSS scores of 4.0 and 6.0. We calculated progression index (PI) and relapse rate (RR). We ascertained MSSS for our patients in the global MSSS table.Results – We found four patients heterozygous for the E2 allele and 16 for the E4 allele. No patient was homozygous for E2 or E4. RR (P = 0.017 with 95% CI: 0.005–0.57) and PI (P = 0.016 with 95% CI: 0.004–0.38) were significantly lower in E4 carriers. MSSS scores were not associated with carriership of E2 or E4.Conclusion – Our results show no effect of the APOE genotype on the severity of MS measured by MSSS, as a recently published meta-analysis has noticed. So, our data do not support a role for APOE in MS severity, in spite of the seeming influence shown using other measures such as PI. MSSS is probably the best method to measure severity with a single measure of disability and should be used more frequently when performing genetic research.","downloadable_attachments":[{"id":48871904,"asset_id":6427851,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":10133075,"first_name":"Jesus","last_name":"Peralta","domain_name":"independent","page_name":"JesusPeralta2","display_name":"Jesus Peralta","profile_url":"https://independent.academia.edu/JesusPeralta2?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":3097,"name":"Multiple sclerosis","url":"https://www.academia.edu/Documents/in/Multiple_sclerosis?f_ri=234187","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false},{"id":73153,"name":"Genetic Testing","url":"https://www.academia.edu/Documents/in/Genetic_Testing?f_ri=234187","nofollow":false},{"id":137946,"name":"Disease 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Markers","url":"https://www.academia.edu/Documents/in/Genetic_Markers?f_ri=234187"},{"id":1318932,"name":"Predictive value of tests","url":"https://www.academia.edu/Documents/in/Predictive_value_of_tests?f_ri=234187"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index?f_ri=234187"},{"id":2474752,"name":"Disability Evaluation","url":"https://www.academia.edu/Documents/in/Disability_Evaluation?f_ri=234187"},{"id":2482159,"name":"DNA mutational analysis","url":"https://www.academia.edu/Documents/in/DNA_mutational_analysis?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_7145933" data-work_id="7145933" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/7145933/Guided_Discontinuation_Versus_Maintenance_Treatment_in_Remitted_First_Episode_Psychosis_Relapse_Rates_and_Functional_Outcome">Guided Discontinuation Versus Maintenance Treatment in Remitted First-Episode Psychosis: Relapse Rates and Functional Outcome</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/7145933" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="b608e8e8d2d6a8e0d7a8749b8d8b9dbc" rel="nofollow" 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});</script></span><script>$(function() { $(".js-view-count-work_7145933").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="7145933"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">7</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="3227" href="https://www.academia.edu/Documents/in/Schizophrenia">Schizophrenia</a>, <script data-card-contents-for-ri="3227" type="text/json">{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="12426" href="https://www.academia.edu/Documents/in/Treatment_Outcome">Treatment Outcome</a>, <script data-card-contents-for-ri="12426" type="text/json">{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="22506" href="https://www.academia.edu/Documents/in/Adolescent">Adolescent</a>, <script data-card-contents-for-ri="22506" type="text/json">{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="23890" href="https://www.academia.edu/Documents/in/Comparative_Study">Comparative Study</a><script data-card-contents-for-ri="23890" type="text/json">{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=7145933]'), work: {"id":7145933,"title":"Guided 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Knegtering","profile_url":"https://independent.academia.edu/RikusKnegtering?f_ri=234187","photo":"https://0.academia-photos.com/12332125/13834199/14922583/s65_rikus.knegtering.jpg"}],"research_interests":[{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia?f_ri=234187","nofollow":false},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome?f_ri=234187","nofollow":false},{"id":22506,"name":"Adolescent","url":"https://www.academia.edu/Documents/in/Adolescent?f_ri=234187","nofollow":false},{"id":23890,"name":"Comparative Study","url":"https://www.academia.edu/Documents/in/Comparative_Study?f_ri=234187","nofollow":false},{"id":234187,"name":"Recurrence","url":"https://www.academia.edu/Documents/in/Recurrence?f_ri=234187"},{"id":437770,"name":"Clinical Psychiatry","url":"https://www.academia.edu/Documents/in/Clinical_Psychiatry?f_ri=234187"},{"id":612870,"name":"Psychotic Disorders","url":"https://www.academia.edu/Documents/in/Psychotic_Disorders?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_10709753" data-work_id="10709753" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/10709753/A_Model_to_Examine_the_Validity_of_the_6Month_Abstinence_Criterion_for_Liver_Transplantation">A Model to Examine the Validity of the 6Month Abstinence Criterion for Liver Transplantation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Six months of abstinence from alcohol is a commonly used criterion for liver transplantation eligibility for patients with alcoholic cirrhosis. There is limited evidence to document the validity of this criterion with regard to risk of... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_10709753" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Six months of abstinence from alcohol is a commonly used criterion for liver transplantation eligibility for patients with alcoholic cirrhosis. There is limited evidence to document the validity of this criterion with regard to risk of alcoholism relapse. Ninety-one patients with alcoholic cirrhosis were interviewed for relapse risk using the High Risk Alcoholism Relapse (HRAR) Scale. The HRAR model can be used to predict relapse risk independent of duration of sobriety and therefore can be used to examine the validity of the 6 months of abstinence criteria in this clinical population. The two methods demonstrated poor to fair agreement. Agreement was highest with a cutoff allowing a 5% 6-month relapse risk when 79% agreement (k= 0.56) was demonstrated between the two methods. Using the 6-month abstinence criterion alone disallows a significant number of candidates who have a low relapse risk based on their HRAR score. The validity of the 6-month abstinence criterion is supported somewhat by comparison with the HRAR model. However, use of the 6-month abstinence criterion alone forces a significant number of patients with a low relapse risk by HRAR to wait for transplant listing. A relapse risk model based on an estimate of alcoholism severity in addition to duration of sobriety may more accurately select patients who are most likely to benefit from liver transplantation.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/10709753" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="930aa01eefedd2ca19c8150ac91dbf64" rel="nofollow" data-download="{"attachment_id":47186335,"asset_id":10709753,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/47186335/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="26125113" href="https://uihealthcare.academia.edu/MichaelVoigt">Michael Voigt</a><script data-card-contents-for-user="26125113" type="text/json">{"id":26125113,"first_name":"Michael","last_name":"Voigt","domain_name":"uihealthcare","page_name":"MichaelVoigt","display_name":"Michael Voigt","profile_url":"https://uihealthcare.academia.edu/MichaelVoigt?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_10709753 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="10709753"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 10709753, container: ".js-paper-rank-work_10709753", }); 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There is limited evidence to document the validity of this criterion with regard to risk of alcoholism relapse. Ninety-one patients with alcoholic cirrhosis were interviewed for relapse risk using the High Risk Alcoholism Relapse (HRAR) Scale. The HRAR model can be used to predict relapse risk independent of duration of sobriety and therefore can be used to examine the validity of the 6 months of abstinence criteria in this clinical population. The two methods demonstrated poor to fair agreement. Agreement was highest with a cutoff allowing a 5% 6-month relapse risk when 79% agreement (k= 0.56) was demonstrated between the two methods. Using the 6-month abstinence criterion alone disallows a significant number of candidates who have a low relapse risk based on their HRAR score. The validity of the 6-month abstinence criterion is supported somewhat by comparison with the HRAR model. However, use of the 6-month abstinence criterion alone forces a significant number of patients with a low relapse risk by HRAR to wait for transplant listing. A relapse risk model based on an estimate of alcoholism severity in addition to duration of sobriety may more accurately select patients who are most likely to benefit from liver transplantation.","downloadable_attachments":[{"id":47186335,"asset_id":10709753,"asset_type":"Work","always_allow_download":false}],"ordered_authors":[{"id":26125113,"first_name":"Michael","last_name":"Voigt","domain_name":"uihealthcare","page_name":"MichaelVoigt","display_name":"Michael Voigt","profile_url":"https://uihealthcare.academia.edu/MichaelVoigt?f_ri=234187","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":221,"name":"Psychology","url":"https://www.academia.edu/Documents/in/Psychology?f_ri=234187","nofollow":false},{"id":2599,"name":"Psychometrics","url":"https://www.academia.edu/Documents/in/Psychometrics?f_ri=234187","nofollow":false},{"id":4888,"name":"Personality 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Results","url":"https://www.academia.edu/Documents/in/Reproducibility_of_Results?f_ri=234187"},{"id":614739,"name":"Temperance","url":"https://www.academia.edu/Documents/in/Temperance?f_ri=234187"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_12825919" data-work_id="12825919" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/12825919/Midluteal_phase_Doppler_assessment_of_uterine_artery_blood_flow_in_nonpregnant_women_having_a_history_of_recurrent_spontaneous_abortions_correlation_to_different_etiologies">Midluteal phase Doppler assessment of uterine artery blood flow in nonpregnant women having a history of 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American","url":"https://www.academia.edu/Documents/in/The_American?f_ri=234187"}]}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_14372806" data-work_id="14372806" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/14372806/Management_of_complicated_coronary_angioplasty_by_intracoronary_urokinase_and_immediate_re_angioplasty">Management of complicated coronary angioplasty by intracoronary urokinase and immediate re-angioplasty</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/14372806" 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href="https://www.academia.edu/Documents/in/Membrane_Proteins">Membrane Proteins</a>, <script data-card-contents-for-ri="11298" type="text/json">{"id":11298,"name":"Membrane Proteins","url":"https://www.academia.edu/Documents/in/Membrane_Proteins?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="82709" href="https://www.academia.edu/Documents/in/Gynecologic_Oncology">Gynecologic Oncology</a>, <script data-card-contents-for-ri="82709" type="text/json">{"id":82709,"name":"Gynecologic Oncology","url":"https://www.academia.edu/Documents/in/Gynecologic_Oncology?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="137516" href="https://www.academia.edu/Documents/in/Follow-up_studies">Follow-up studies</a>, <script data-card-contents-for-ri="137516" type="text/json">{"id":137516,"name":"Follow-up studies","url":"https://www.academia.edu/Documents/in/Follow-up_studies?f_ri=234187","nofollow":false}</script><a class="InlineList-item-text" data-has-card-for-ri="181569" href="https://www.academia.edu/Documents/in/Proteins">Proteins</a><script data-card-contents-for-ri="181569" type="text/json">{"id":181569,"name":"Proteins","url":"https://www.academia.edu/Documents/in/Proteins?f_ri=234187","nofollow":false}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=22099797]'), work: {"id":22099797,"title":"Evaluation of ovarian cancer remission markers HE4, MMP7 and Mesothelin by comparison to the established marker 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href="https://www.academia.edu/16141238/Single_agent_carboplatin_for_CS_IIA_B_testicular_seminoma_A_phase_II_study_of_the_German_Testicular_Cancer_Study_Group_GTCSG_">Single agent carboplatin for CS IIA/B testicular seminoma. A phase II study of the German Testicular Cancer Study Group (GTCSG)</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16141238" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6de3454f77758dafd994efd447b05d38" rel="nofollow" data-download="{"attachment_id":42675744,"asset_id":16141238,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/42675744/download_file?st=MTczMjczNjc0Niw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="35254192" href="https://wolfgang-maier.academia.edu/AxelHinke">Axel Hinke</a><script data-card-contents-for-user="35254192" type="text/json">{"id":35254192,"first_name":"Axel","last_name":"Hinke","domain_name":"wolfgang-maier","page_name":"AxelHinke","display_name":"Axel Hinke","profile_url":"https://wolfgang-maier.academia.edu/AxelHinke?f_ri=234187","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_16141238 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16141238"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16141238, container: ".js-paper-rank-work_16141238", }); 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u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_19792009" data-work_id="19792009" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/19792009/Randomized_Controlled_Trial_of_a_Low_Animal_Protein_High_Fiber_Diet_in_the_Prevention_of_Recurrent_Calcium_Oxalate_Kidney_Stones">Randomized Controlled Trial of a Low Animal Protein, High Fiber Diet in the Prevention of Recurrent Calcium Oxalate Kidney Stones</a></div></div><div class="u-pb4x u-mt3x"></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/19792009" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span 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