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href="https://www.guidetopharmacology.org/about.jsp">About The Guide to PHARMACOLOGY</a></li> <li><a href="https://www.guidetopharmacology.org/nciuphar.jsp">About NC-IUPHAR</a></li> <li><a href="https://www.guidetopharmacology.org/GRAC/ContributorListForward">Contributors</a></li> <li><a href="https://www.guidetopharmacology.org/sponsors.jsp">Sponsors</a></li> <li><a href="https://www.guidetopharmacology.org/citing.jsp">Citing</a></li> <li><a href="https://www.guidetopharmacology.org/linking.jsp">Linking to us</a></li>  <li><a href="https://www.guidetopharmacology.org/disclaimer.jsp">Disclaimer</a></li> <li><a href="https://www.guidetopharmacology.org/privacyPolicy.jsp">Privacy and Cookie Policy</a></li> </ul> </li> </ul> </li> <li> <a href="/GRAC/FamilyDisplayForward?familyId=970">Targets</a> <ul> <li> <a href="/GRAC/FamilyDisplayForward?familyId=970">Antimalarial targets</a> </li> </ul> </li> <li> <a href="/GRAC/LigandListForward?type=All">Ligands</a> <ul> <li><a href="/GRAC/LigandListForward?type=All">Ligand list</a></li> <li><a href="/GRAC/LigandFamiliesForward">Ligand families</a></li> <li><a href="/GRAC/chemSearch.jsp">Ligand search</a></li> </ul> </li> <li> <a href="/GRAC/ParasiteLifecycleStagesForward">Lifecycle</a> <ul> <li><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=1">Plasmodium liver stage</a></li> <li><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=2">Plasmodium dormant liver stage</a></li> <li><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=3">Plasmodium asexual blood stage</a></li> <li><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=4">Plasmodium sexual blood stage</a></li> <li><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=5">Plasmodium mosquito host</a></li> </ul> </li>  <li> <a href="/GRAC/MalariaTargetSpeciesForward">Species</a> <ul> <li><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=103"><i>P. falciparum</i></a></li> <li><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=104"><i>P. vivax</i></a></li> <li><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=126"><i>P. knowlesi</i></a></li> <li><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=109"><i>P. berghei</i></a></li> <li><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=107"><i>P. cynomolgi</i></a></li> <li><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=121"><i>P. yoelii</i></a></li> </ul> </li> <li> <a href="/malaria/gtmpHelpPage.jsp">Resources</a> <ul> <li><a href="/malaria/gtmpHelpPage.jsp">GtoMPdb Help</a></li> <li> <a href="https://www.guidetopharmacology.org/helpPage.jsp">GtoPdb Help</a> <ul> <li><a href="https://www.guidetopharmacology.org/faq.jsp">FAQ</a></li> <li><a href="https://www.guidetopharmacology.org/pdfs/termsAndSymbols.pdf" target="_blank" onClick="recordEvent(this, 'Other files', 'View PDF', 'Terms and Symbols');return false;">Terms and symbols</a></li> <li><a href="https://www.guidetopharmacology.org/nomenclature.jsp">Nomenclature guidelines</a></li> <li><a href="https://www.guidetopharmacology.org/nciupharPublications.jsp">Publications</a></li> <li><a href="https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2" target="_blank" onClick="recordEvent(this, 'BJP links', 'https://bpspubs.onlinelibrary.wiley.com/toc/14765381/2023/180/S2', 'CGTP table of contents');return false;">Concise Guide to PHARMACOLOGY</a></li> <li><a href="https://www.guidetopharmacology.org/links.jsp">Useful links</a></li> </ul> </li> <li><a href="https://www.guidetopharmacology.org/download.jsp">GtoPdb Downloads</a> <ul> <li><a href="https://www.guidetopharmacology.org/download.jsp">Download data and reports</a></li> <li><a href="https://www.guidetopharmacology.org/webServices.jsp">Web services</a></li> <li><a href="https://www.guidetopharmacology.org/slides.jsp">Slides and posters</a></li> </ul> </li> <li><a href="https://www.guidetopharmacology.org/news.jsp">GtoPdb News</a> <ul> <li><a href="https://www.guidetoimmunopharmacology.org/immuno/immuphar2018.jsp">Immunopharmacology Meeting 2018</a></li> <li><a href="https://www.guidetopharmacology.org/news.jsp">Latest GtoPdb news</a></li> <li><a href="https://www.guidetopharmacology.org/GRAC/HotTopicsForward">Hot topics</a></li> </ul> </li> </ul> </li>  <li class="gtop_home"> <a href="https://www.guidetopharmacology.org/index.jsp">Guide to PHARMACOLOGY</a> </li> </ul>    </div> </div>      <div class="grid_12">  <div class="grid_6 alpha"> <div class="gtmp_backandborder row1"> <div style="display: flex;"> <div style="max-width:300px;"> <h4>Targets</h4> </div> <div style="flex-grow: 1;"> <h4 style="text-align:right;"> <a class="popup-trigger" rel="nofollow" title="View targets data help"> <img id="logo" style="vertical-align:baseline; height:22px;" src="../images/white_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='../images/white_transparent_help_icon_hovermalaria.png';" onmouseout="this.src='../images/white_transparent_help_icon.png';")"/> </a> <div class="popup" style="text-align:left;"> <p>Select ‘Antimalarial targets’ to browse all the targets for this family. From there you can navigate to individual target pages and find detailed information about each target and its interactions.</p> <p> Click '<a href="/GRAC/searchPage.jsp">Search for targets</a>' to search for targets in the database.</p> <p>Further details on viewing antimalarial target data can be found in the <a href="gtmpHelpPage.jsp#targetPages" target="_blank">GtoMPdb help</a>. More general information on viewing target data can be found in the main <a href="../helpPage.jsp#targetPages" target="_blank">GtoPdb help pages.</a> </p> <span class="popup-btn-close">✖</span> </div> </h4> </div> </div> <div class="contentbox"> <div class="imageleft"> <img src="../images_dev27082012/GPCR_small.jpg" width="78" height="76" alt=" "/> </div> <div class="textright"> <ul class="arrowlist"> <li style="margin-bottom: 15px;"><a href="/GRAC/FamilyDisplayForward?familyId=970">Antimalarial targets</a></li> <li style="list-style: none;"> <a href="/GRAC/searchPage.jsp">Search for targets</a> <a href="/GRAC/searchPage.jsp"><img src="../images_dev27082012/go.jpg"></a></li> </ul> </div> </div> </div> </div>   <div class="grid_6 omega"> <div class="gtmp_backandborder row1"> <div style="display: flex;"> <div style="max-width:300px;"> <h4>Ligands</h4> </div> <div style="flex-grow: 1;"> <h4 style="text-align:right;"> <a class="popup-trigger" rel="nofollow" title="View Ligands data help"> <img id="logo" style="vertical-align:baseline; height:22px;" src="../images/white_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='../images/white_transparent_help_icon_hovermalaria.png';" onmouseout="this.src='../images/white_transparent_help_icon.png';")"/> </a> <div class="popup" style="text-align:left;"> <p>Select a ligand category to view ligands under that category. From there you can navigate to individual ligand summary pages for more detailed information.</p> <p>Click '<a href="/GRAC/chemSearch.jsp">Search for ligands</a>' to search for ligands in the database</p> <p>Further details on viewing antimalarial ligand data can be found in the <a href="gtmpHelpPage.jsp#ligand" target="_blank">GtoMPdb help</a>. More general information on viewing ligand data can be found in the main <a href="../helpPage.jsp#ligand" target="_blank">GtoPdb help pages.</a> </p> <span class="popup-btn-close">✖</span> </div> </h4> </div> </div> <div class="contentbox"> <div class="imageleft"> <img src="../images_dev27082012/ligand_small.png" width="78" height="76" alt=" "/> </div> <div class="textright"> <ul class="arrowlist" style="margin-bottom:2px;"> <li style="margin-bottom: 5px;"><a href="/GRAC/LigandListForward?type=All">All antimalarial drugs</a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/LigandListForward?type=Approved">Approved antimalarial drugs</a></li> <li style="list-style: none;"> <a href="/GRAC/chemSearch.jsp">Search for ligands </a> <a href="/GRAC/chemSearch.jsp"><img src="../images_dev27082012/go.jpg"></a></li> </ul> </div> </div> </div> </div>   <div class="grid_6 alpha"> <div class="gtmp_backandborder row2"> <div style="display: flex;"> <div style="max-width:500px;"> <h4>Parasite Lifecycle Stages</h4> </div> <div style="flex-grow: 1;"> <h4 style="text-align:right;"> <a class="popup-trigger" rel="nofollow" title="View parasite lifecycle data help"> <img id="logo" style="vertical-align:baseline; height:22px;" src="../images/white_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='../images/white_transparent_help_icon_hovermalaria.png';" onmouseout="this.src='../images/white_transparent_help_icon.png';")"/> </a> <div class="popup" style="text-align:left;"><h3>Parasite Lifecycle Data</h3> <p>The Guide to MALARIA PHARMACOLOGY contains data detailing the parasitic lifecycle activity for antimalarial ligands and their target interactions. The list of categories you see here are top-level Plasmodium lifecycle stages (collective categories for one or more developmental forms of the parasite) defined by GtoMPdb against which interactions in the database have been annotated.</p> <p>Click on a category to see a description of the lifecycle stage and all interactions associated with it, or select '<a href="../GRAC/ParasiteLifecycleStagesForward">View parasite lifecycle home page</a>' to see a summary page including more general information about the Plasmodium lifecycle.</p> <span class="popup-btn-close">✖</span>  </div> </h4> </div> </div> <div class="contentbox"> <div class="imageleft"> <img src="../images/malaria/gtmp_lifecycles.jpg" width="78" height="76" alt=" "/> </div> <div class="textright"> <ul class="arrowlist" style="margin-bottom:2px;"> <li style="margin-bottom: 5px;"><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=1">Plasmodium liver stage</a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=2">Plasmodium dormant liver stage</a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=3">Plasmodium asexual blood stage</a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=4">Plasmodium sexual blood stage</a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/ParasiteLifecycleDisplayForward?stageId=5">Plasmodium mosquito host</a></li> <li style="list-style: none;"> <a href="/GRAC/ParasiteLifecycleStagesForward">View parasite lifecycle home page</a> <a href="/GRAC/ParasiteLifecycleForward"><img src="../images_dev27082012/go.jpg"></a> </li> </ul> </div> </div> </div> </div>   <div class="grid_6 omega"> <div class="gtmp_backandborder row2"> <div style="display: flex;"> <div style="max-width:300px;"> <h4>Target Species</h4> </div> <div style="flex-grow: 1;"> <h4 style="text-align:right;"> <a class="popup-trigger" rel="nofollow" title="View Ligands data help"> <img id="logo" style="vertical-align:baseline; height:22px;" src="../images/white_transparent_help_icon.png" alt="Click here for help" onmouseover="this.src='../images/white_transparent_help_icon_hovermalaria.png';" onmouseout="this.src='../images/white_transparent_help_icon.png';")"/> </a> <div class="popup" style="text-align:left;"> <h3>Target Species Data</h3> <p>The Guide to MALARIA PHARMACOLOGY includes species information for antimalarial ligands and their target interactions. The list of categories you see here are Plasmodium species against which interactions in the database have been annotated.</p> <p>Click on a category to see a species description and all interactions associated with it, or select '<a href="../GRAC/MalariaTargetSpeciesForward">View target species home page</a>' to see a summary page including more general information about Plasmodium species.</p> <span class="popup-btn-close">✖</span> </div> </h4> </div> </div> <div class="contentbox"> <div class="imageleft"> <img src="../images/malaria/species_mmv_icon.jpg" width="78" height="76" alt=" "/> </div> <div class="textright"> <ul class="arrowlist" style="margin-bottom:2px;"> <li style="margin-bottom: 5px;"><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=103"><i>P. falciparum</i></a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=104"><i>P. vivax</i></a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=126"><i>P. knowlesi</i></a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=109"><i>P. berghei</i></a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=107"><i>P. cynomolgi</i></a></li> <li style="margin-bottom: 5px;"><a href="/GRAC/MalariaTargetSpeciesDisplayForward?speciesId=121"><i>P. yoelii</i></a></li> <li style="list-style: none;"> <a href="/GRAC/MalariaTargetSpeciesForward">View target species home page</a> <a href="/GRAC/MalariaTargetSpeciesForward"><img src="../images_dev27082012/go.jpg"></a> </li> </ul> </div> </div> </div> </div>    <div class="grid_6 alpha"> <div class="gtmp_backandborder row2"> <h4>World Congress of Pharmacology 2023</h4> <div class="contentbox"> <div class="imageleft"> <a style="color:white;" href="https://wcp2023.org/events/drug-discovery-and-development-for-malaria/" target="_blank"> <img src="../images/WCP2023logo.png" width="120" height="120" alt=" "/></a> </div> <div class="textright"> <p>Come join for our symposum at WCP 2023 in Glasgow</p> <p>3rd July 2023<br><a href="https://wcp2023.org/events/drug-discovery-and-development-for-malaria/" target="_blank"> WCP 2023 Symposium:<br>Drug discovery and development for Malaria</p> </div> </div> </div> </div>   <div class="grid_6 omega"> <div class="gtmp_backandborder row2"> <h4>BJP IUPHAR Review</h4> <div class="contentbox"> <a style="color:white;" href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16144" target="_blank"> <img align="left" src="../images/bjp_thumb.jpg" alt="BJP Cover" width="100px" style="margin:10px 10px 2px 4px"/> </a> <p style="padding:5px 5px 0px 15px; line-height: 1.6;">Recently published online in the British Journal of Pharmacology a new IUPHAR Review on <a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16144" target="_blank"/><b>Advances in Malaria Pharmacology and the online Guide to MALARIA PHARMACOLOGY: IUPHAR Review X</b> </p> </div> </div> </div>  </div>  <div class="grid_4 omega"> <div class="gtmp_backandborder"> <h4>Help</h4> <div class="contentbox"> <h3>Help</h3> <p>View our <a href="gtmpHelpPage.jsp">help page</a> for information about the data in and using the Guide to MALARIA PHARMACOLOGY.</p> </div> </div>  <script> if (jQuery.cookie('cc_cookie_accept') == "cc_cookie_accept") { $('#social_media_cookies').hide(); do_twitter_widget(document,'script','twitter-wjs'); $('#twitter').show(); } </script> </div>  <div class="clear"></div> <script> // Popup Window var scrollTop = ''; var newHeight = '100'; /* $(window).bind('scroll', function() { scrollTop = $( window ).scrollTop(); newHeight = scrollTop + 100; }); 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