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16px;font-size:14px;font-family:Roboto,Arial,Helvetica,sans-serif;line-height:36px;letter-spacing:.5px;text-transform:uppercase;-webkit-box-shadow:none;box-shadow:none;text-decoration:none;color:#fff;background-color:#00bcd4}.webmd-input__inner,.webmd-label,.webmd-label.labelup{font-weight:400;letter-spacing:normal}.webmd-button.material:active,.webmd-button.material:focus,.webmd-button.material:hover{color:#fff;background-color:#0097a7}.webmd-button.material.is-shadow{-webkit-box-shadow:0 2px 4px 0 rgba(0,0,0,.3);box-shadow:0 2px 4px 0 rgba(0,0,0,.3)}.webmd-button.material.is-capitalized{text-transform:capitalize}.webmd-button:hover{background-color:#00588c;color:#fff}.webmd-button+.webmd-button{margin-left:.625rem}.webmd-button::-moz-focus-inner{border-style:none}.webmd-button.is-icon{padding-left:1rem;padding-right:1rem}.webmd-button 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.vn-none{display:none!important}}.vn-wrapper .vn-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;height:3rem;margin:0 auto;max-width:77.5rem;z-index:1}@media(min-width:64.0625rem){.vn-wrapper .vn-container{height:4.6875rem}}.vn-wrapper .vn-container.lite{max-width:100%}@media(min-width:64.0625rem){.vn-wrapper .vn-container.lite{height:3.5rem}}.vn-wrapper .vn-menu-btn{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:none;border:0;color:#fff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;height:100%;line-height:1;padding:0}.vn-wrapper .vn-menu-btn:not(.lite){margin-right:1.166875rem}@media(min-width:64.0625rem){.vn-wrapper .vn-menu-btn:not(.lite){margin-right:0}}.vn-wrapper .vn-menu-btn i{font-size:2.25rem;width:2.25rem;overflow:hidden}.vn-wrapper .vn-menu-btn svg{fill:currentColor;pointer-events:none}.vn-wrapper .vn-menu-btn.vn-search i{font-size:1.875rem;width:1.875rem}.vn-wrapper .vn-menu-btn.vn-search:not(.lite){margin-right:0}@media(min-width:64.0625rem){.vn-wrapper .vn-menu-btn.vn-search:not(.lite) i{font-size:1.625rem;width:1.625rem}}.vn-wrapper .vn-menu-btn.vn-search.lite i{font-size:2rem;width:2rem}.vn-wrapper .vn-logo-container{-webkit-box-align:center;-ms-flex-align:center;align-items:center;display:-webkit-box;display:-ms-flexbox;display:flex}.vn-wrapper .vn-logo-container .vn-logo-div{height:.9375rem;margin:0 .625rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo-div{height:1.5625rem;margin:0 1.25rem}}.vn-wrapper .vn-logo-container .vn-logo,.vn-wrapper .vn-logo-container .vn-prog-logo{line-height:1}.vn-wrapper .vn-logo-container .vn-logo img,.vn-wrapper .vn-logo-container .vn-prog-logo img{display:block;height:1.3125rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo img,.vn-wrapper .vn-logo-container .vn-prog-logo img{height:1.625rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container .vn-logo img:not(.lite){width:7.25rem}}.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:.875rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container.with-program .vn-logo img{height:1.4375rem}}.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:.9375rem}@media(min-width:64.0625rem){.vn-wrapper .vn-logo-container.with-program .vn-prog-logo img{height:1.5625rem}}.vn-wrapper .vn-links{background:#f9f9fc;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-orient:vertical;-webkit-box-direction:normal;-ms-flex-direction:column;flex-direction:column;height:calc(100vh - 3rem);left:-140vw;overflow:auto;padding:.5rem;position:fixed;top:3rem;-webkit-transition:left .5s ease;transition:left .5s ease;width:100%;z-index:100}@media(min-width:37.5rem){.vn-wrapper .vn-links{max-width:25rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links.lite{height:calc(100vh - 3.5rem);top:3.5rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links:not(.lite){background:none;-webkit-box-orient:horizontal;-webkit-box-direction:normal;-ms-flex-direction:row;flex-direction:row;height:100%;left:0;max-width:100%;overflow:visible;padding:0;position:relative;top:0}}.vn-wrapper .vn-links.open{left:0}.vn-wrapper .vn-links.open.vn-slide-out{left:-100vw}@media(min-width:37.5rem){.vn-wrapper .vn-links.open.vn-slide-out{left:0}}.vn-wrapper .vn-links .vn-search-wrapper{display:-webkit-box;display:-ms-flexbox;display:flex;height:3rem;margin-bottom:.25rem;-webkit-box-ordinal-group:0;-ms-flex-order:-1;order:-1}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-search-wrapper:not(.lite){background:#fff;border:1px solid #c6cedb;border-radius:5px;opacity:0;-webkit-box-ordinal-group:2;-ms-flex-order:1;order:1;position:absolute;right:2.8125rem;top:.8125rem;width:38%;-webkit-transition:all .3s ease;transition:all .3s 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i{font-size:.625rem;margin-left:.3125rem;-webkit-transition:transform .3s ease;transition:transform .3s ease}.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:hover>a{background:#fff;color:#00157c}.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:hover>a i{-webkit-transform:rotate(180deg);transform:rotate(180deg)}.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:hover .vn-menu-section{left:0;opacity:1;visibility:visible}.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:focus-visible>a,.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:has(:focus-visible)>a{background:#fff;color:#1b1b1b}.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:focus-visible>a i,.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:has(:focus-visible)>a i{-webkit-transform:rotateX(180deg);transform:rotateX(180deg)}.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:focus-visible .vn-menu-section,.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:has(:focus-visible) .vn-menu-section{left:0;opacity:1;visibility:visible}}@media(min-width:81.25rem){.vn-wrapper .vn-links .vn-links-list:not(.lite)>li:not(:nth-child(7)){margin-right:1rem}}.vn-wrapper .vn-links .vn-menu-section{background:#f9f9fc;height:calc(100vh - 3rem);right:-140vw;overflow:auto;padding:0 1.5rem 6.25rem 1.5rem;position:fixed;top:3rem;-webkit-transition:all .5s ease;transition:all .5s ease;width:100%;z-index:10}.vn-wrapper .vn-links .vn-menu-section.lite{height:calc(100vh - 3.5rem);top:3.5rem}@media(min-width:37.5rem){.vn-wrapper .vn-links .vn-menu-section{max-width:25rem;left:-140vw;right:auto}.vn-wrapper .vn-links .vn-menu-section.open{left:0;right:auto}}.vn-wrapper .vn-links .vn-menu-section.open{right:0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header{-webkit-box-align:center;-ms-flex-align:center;align-items:center;border-bottom:1px solid #c6cedb;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:justify;-ms-flex-pack:justify;justify-content:space-between;padding:.75rem 0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header .nav-title{color:#1b1b1b;font-size:1.25rem;line-height:1;margin:0}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header a{color:#3557ff;font-weight:400;text-decoration:none}.vn-wrapper .vn-links .vn-menu-section .vn-menu-section-header a img{margin-right:.5rem;width:.8125rem}.vn-wrapper .vn-links .vn-menu-section ul{margin:.75rem 0;list-style:none;padding:0}.vn-wrapper .vn-links .vn-menu-section ul li{font-size:1.125rem;font-weight:400}.vn-wrapper .vn-links .vn-menu-section ul li a{color:#1b1b1b;display:block;padding:.75rem 0;text-decoration:none}.vn-wrapper .vn-links .vn-menu-section ul li a:hover{color:#3557ff}.vn-wrapper .vn-links .vn-menu-section ul li hr{border:1px solid #c6cedb}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-menu-section:not(.lite){background:#fff;border-radius:0 0 5px 5px;border-top:0;left:-20px;margin-left:-3.75rem;max-width:none;height:auto;opacity:0;padding:1.875rem 2.875rem;position:absolute;top:4.6875rem;width:18.75rem;visibility:hidden}.vn-wrapper .vn-links .vn-menu-section:not(.lite) hr{display:none}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul{margin:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li{border-bottom:1px solid #c6cedb}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li:last-of-type{border-bottom:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li.vn-see-all a{-webkit-box-align:baseline;-ms-flex-align:baseline;align-items:baseline;color:#3557ff;display:-webkit-box;display:-ms-flexbox;display:flex;-webkit-box-pack:start;-ms-flex-pack:start;justify-content:flex-start}.vn-wrapper .vn-links .vn-menu-section:not(.lite) ul li.vn-see-all a img{height:.75rem;margin-right:.5rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1{width:60.9375rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul{-webkit-columns:4;-moz-columns:4;columns:4;-webkit-column-gap:2.875rem;-moz-column-gap:2.875rem;column-gap:2.875rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(7),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(14),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1 ul li:nth-child(21){border-bottom:0}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3{width:35rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul{-webkit-columns:2;-moz-columns:2;columns:2;-webkit-column-gap:2.875rem;-moz-column-gap:2.875rem;column-gap:2.875rem}.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul li:nth-child(8),.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-3 ul li:nth-child(16){border-bottom:0}}@media(min-width:64.0625rem)and (max-width:81.25rem){.vn-wrapper .vn-links .vn-menu-section:not(.lite).hdr-site-1{margin-left:-8.75rem}}.vn-wrapper .vn-links .vn-back{-webkit-box-align:center;-ms-flex-align:center;align-items:center;background:none;border:0;color:#3557ff;cursor:pointer;display:-webkit-box;display:-ms-flexbox;display:flex;padding:1rem 0}.vn-wrapper .vn-links .vn-back i{font-size:.75rem;margin-right:.3125rem}.vn-wrapper .vn-links .vn-actions{margin-top:1rem}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions:not(.lite){-webkit-box-align:center;-ms-flex-align:center;align-items:center;border-left:1px solid #cccce7;display:-webkit-box;display:-ms-flexbox;display:flex;margin:1.1875rem 0;padding-left:1.25rem}}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe{border-left:none}}.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe .vn-signin{padding-left:.9375rem}@media(min-width:64.0625rem){.vn-wrapper .vn-links .vn-actions:not(.lite).no-subscribe .vn-signin{padding-left:0}}.vn-wrapper .vn-links 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href="https://doctor.webmd.com/" class="links"><svg width="70" height="70" viewBox="0 0 70 70" fill="none" xmlns="https://www.w3.org/2000/svg"><title>Find a Doctor</title><circle cx="35" cy="35" r="35" fill="white"></circle><circle cx="35" cy="33.5" r="20" stroke="#3557FF" stroke-width="2"></circle><path d="M48 49.5L53.75 56.3536" stroke="#3557FF" stroke-width="2" stroke-linecap="round"></path><path fill-rule="evenodd" clip-rule="evenodd" d="M29.9545 23.2727C29.9545 22.0175 30.9721 21 32.2273 21H36.7727C38.0279 21 39.0455 22.0175 39.0455 23.2727V28.9545H44.7273C45.9825 28.9545 47 29.9721 47 31.2273V35.7727C47 37.0279 45.9825 38.0455 44.7273 38.0455H39.0455V43.7273C39.0455 44.9825 38.0279 46 36.7727 46H32.2273C30.9721 46 29.9545 44.9825 29.9545 43.7273V38.0455H24.2727C23.0175 38.0455 22 37.0279 22 35.7727V31.2273C22 29.9721 23.0175 28.9545 24.2727 28.9545H29.9545V23.2727Z" fill="#D2D9FF"></path><path d="M31 21.5V30H22.5C22.2239 30 22 30.2239 22 30.5V36.5C22 36.7761 22.2239 37 22.5 37H31V45.5C31 45.7761 31.2239 46 31.5 46H37.5C37.7761 46 38 45.7761 38 45.5V37H46.5C46.7761 37 47 36.7761 47 36.5V30.5C47 30.2239 46.7761 30 46.5 30H38V21.5C38 21.2239 37.7761 21 37.5 21H31.5C31.2239 21 31 21.2239 31 21.5Z" stroke="#3557FF" stroke-width="2"></path></svg><label>Find a <br> Doctor</label></a></div></div><div class="faq-section"><div class="header-section"><h2>Drug Interactions: What You Need to Know</h2><p class="authors">By <a href="https://www.webmd.com/evan-starkman">Evan Starkman</a></p><p class="reviewer-info">Medically Reviewed by <a href="https://www.webmd.com/joshua-conrad">Joshua Conrad, PharmD</a></p></div><div class="material"><div class="webmd-collapse" role="tablist" aria-multiselectable="true"><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-8443" aria-describedby="webmd-collapse-content-8443"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-8443" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3>What Are Drug Interactions?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-8443" id="webmd-collapse-content-8443"><div class="webmd-collapse-item__content"><p>When a <a href="https://www.webmd.com/drugs/index-drugs.aspx">medication</a> works right, it boosts your health or helps you feel better. But a drug can bring on problems if it doesn't mix well with something else you put into your body, like another medication, a certain food, or <a href="https://www.webmd.com/food-recipes/rm-quiz-alcohol-myths-facts">alcohol</a>.</p><p>When that happens, it's called a <a href="https://www.webmd.com/interaction-checker/default.htm">drug interaction</a>. It could make your medication stop working, become less effective, or too strong. It could also trigger side effects.</p><p>The more you learn about drug interactions, the better you'll be able to avoid them. Here's what you need to know.</p></div></div></div><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-9333" aria-describedby="webmd-collapse-content-9333"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-9333" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3>What Are the 3 Types of Drug Interactions?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-9333" id="webmd-collapse-content-9333"><div class="webmd-collapse-item__content"><p>The main types are:</p><p><b>Drug-drug interaction</b>. This is when a medication reacts with one or more other drugs. For example, taking a <a href="https://www.webmd.com/cold-and-flu/cold-guide/cough-syrup-cough-medicine">cough medicine</a> (<a href="https://www.webmd.com/drugs/drug-54333-antitussive+oral.aspx">antitussive</a>) and a drug to help you <a href="https://www.webmd.com/sleep-disorders/default.htm">sleep</a> (sedative) could cause the two medications to affect each other.</p><p><b>Drug-food/drink interaction</b>. This is when something you eat or drink affects a drug. For instance, it can be dangerous to drink alcohol while you're on certain medications. Some <a href="https://www.webmd.com/vitamins-and-supplements/lifestyle-guide-11/default.htm">vitamins</a> and <a href="https://www.webmd.com/vitamins-and-supplements/supplement-faq">dietary supplements</a> interact with medicines, too.</p><p><b>Drug-condition interaction</b>. This is when you have a health problem that makes it risky for you to take certain meds. For example, if you have a condition like <a href="https://www.webmd.com/hypertension-high-blood-pressure/default.htm">high blood pressure</a>, taking a <a href="https://www.webmd.com/allergies/decongestants">decongestant</a> for a <a href="https://www.webmd.com/cold-and-flu/default.htm">cold</a> could drive up your <a href="https://www.webmd.com/hypertension-high-blood-pressure/guide/diastolic-and-systolic-blood-pressure-know-your-numbers">blood pressure</a> even more.</p></div></div></div><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-6423" aria-describedby="webmd-collapse-content-6423"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-6423" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3>What Drugs Can You Not Take Together?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-6423" id="webmd-collapse-content-6423"><div class="webmd-collapse-item__content"><p>There are many types of drugs you shouldn't take together, but in general, don't take combinations like these:</p><p><b>Two or more drugs that share an active ingredient.</b> You could have side effects or an <a href="https://www.webmd.com/mental-health/addiction/drug-overdose">overdose</a>. Active ingredients are the chemicals in medications that treat your condition or symptoms. Always check for them on the drug label.</p><p><b>Blood-thinning drugs with <a href="https://www.webmd.com/arthritis/features/pain-relief-how-nsaids-work">NSAIDs</a></b>. Your odds for a dangerous bleed could go up. NSAIDs (nonsteroidal anti-inflammatory drugs) are pain relievers like <a href="https://www.webmd.com/drugs/mono-9368-IBUPROFEN+-+ORAL.aspx?drugid=5166&drugname=ibuprofen+oral">ibuprofen</a> or <a href="https://www.webmd.com/drugs/mono-1289-NAPROXEN+-+ORAL.aspx?drugid=5173&drugname=Naproxen+Oral">naproxen</a>. If you're on a blood thinner, ask your doctor to suggest a different type of over-the-counter pain medication and dose that's safer for you.</p><p><b>Pills with antihistamines.</b> Taking these together can cause you to react more slowly, which would make it dangerous for you to drive or work with heavy machines.</p><p>Some other drug-drug combinations that can be dangerous are:</p><ul><li>An NSAID pain reliever with a blood pressure drug</li><li>A thyroid drug called <a href="https://www.webmd.com/drugs/2/drug-1433/levothyroxine+oral/details">levothyroxine</a> with an acid-blocking proton pump inhibitor drug called <a href="https://www.webmd.com/drugs/2/drug-3766/omeprazole+oral/details">omeprazole</a></li><li>An <a href="https://www.webmd.com/depression/guide/depression-medications-antidepressants">SSRI</a> antidepressant with another medicine that affects serotonin (such as <a href="https://www.webmd.com/drugs/drug-77506-dmax+oral.aspx">dextromethorphan</a>, <a href="https://www.webmd.com/drugs/mono-6154-LINEZOLID+-+ORAL.aspx?drugid=18168&drugname=linezolid+oral">linezolid</a>, tramadol, and <a href="https://www.webmd.com/drugs/2/drug-11188/trazodone+oral/details">trazodone</a>)</li><li>A cholesterol-lowering <a href="https://www.webmd.com/cholesterol-management/video/should-i-take-a-statin">statin</a> with antifungal and fibrate meds that are commonly called "azole" drugs (Their technical names are "imidazole and triazole derivatives." They lower blood fats called <a href="https://www.webmd.com/cholesterol-management/lowering-triglyceride-levels">triglycerides</a>.)</li><li>The antibiotic clarithromycin with a type of blood pressure drug called a calcium channel blocker</li></ul></div></div></div><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-4775" aria-describedby="webmd-collapse-content-4775"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-4775" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3>What Are Common Drug Interactions?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-4775" id="webmd-collapse-content-4775"><div class="webmd-collapse-item__content"><p>Certain foods and drinks don't mix well with some medications. A few of these are:</p><p><b>Alcohol</b>. Booze can bring on dangerous side effects with many medications, including some drugs for:</p><ul><li><a href="https://www.webmd.com/allergies/default.htm">Allergies</a></li><li>Cold and flu</li><li><a href="https://www.webmd.com/cholesterol-management/default.htm">High cholesterol</a></li><li>High blood pressure</li><li><a href="https://www.webmd.com/add-adhd/default.htm">Attention deficit hyperactivity disorder</a> (ADHD)</li><li><a href="https://www.webmd.com/depression/default.htm">Depression</a></li><li><a href="https://www.webmd.com/diabetes/default.htm">Diabetes</a></li><li>Infections</li><li><a href="https://www.webmd.com/pain-management/default.htm">Pain</a></li><li>Poor sleep</li></ul><p>Before you start a new medication, ask your doctor or <a href="https://www.webmd.com/a-to-z-guides/features/pharmacists-they-do-more-than-fill-prescriptions">pharmacist</a> if it could interact with alcohol. Check the drug label for alcohol warnings, too.</p><p><b>Grapefruit or grapefruit juice.</b> Too much of either can affect some drugs like:</p><ul><li><a href="https://www.webmd.com/cholesterol-management/side-effects-of-statin-drugs">Statins</a></li><li><a href="https://www.webmd.com/allergies/antihistamines-for-allergies">Antihistamines</a></li><li><a href="https://www.webmd.com/hypertension-high-blood-pressure/how-take-blood-pressure-medicine-properly-why-you-should">Blood pressure drugs</a></li><li><a href="https://www.webmd.com/anxiety-panic/default.htm">Anxiety</a> meds</li><li>Transplant anti-rejection drugs</li></ul><p>Grapefruit juice doesn't mix badly with every type of drug in these classes of medications. Check your drug's label or information pamphlet for any warnings about it. Also, ask your doctor or pharmacist if it's safe to have grapefruit or its juice in any amount with your specific drug. If they tell you to stop eating or drinking it, ask if any other fruits or juices might have similar effects on your medicine.</p><p><b><a href="https://www.webmd.com/vitamins-and-supplements/supplement-guide-vitamin-k">Foods with vitamin K</a></b>, like leafy <a href="https://www.webmd.com/food-recipes/ss/slideshow-greens">greens</a>. These can interact with the <a href="https://www.webmd.com/heart-disease/ss/slideshow-tips-for-taking-blood-thinners">blood thinner</a> warfarin. You don't have to stop eating them, but it's important to be consistent and not overdo it. Ask your doctor how much food with vitamin K you can have, then eat the same amount around the same times each week.</p><p><b>High-<a href="https://www.webmd.com/diet/supplement-guide-potassium">potassium</a> foods and drinks</b>, like bananas, salt substitutes, and orange juice. These can affect blood pressure drugs called <a href="https://www.webmd.com/heart-disease/guide/medicine-ace-inhibitors">ACE inhibitors</a>. Your doctor will track your potassium levels, and they may tell you to cut back on foods with it.</p><p><b>St. John's wort</b>. This herbal dietary supplement can affect many medications for heart disease, <a href="https://www.webmd.com/hiv-aids/default.htm">HIV</a>, <a href="https://www.webmd.com/depression/understanding-depression-basics">depression</a>, and other conditions. It can also affect <a href="https://www.webmd.com/sex/birth-control/birth-control-pills">birth control pills</a> and the <a href="https://www.webmd.com/cancer/default.htm">cancer</a> drugs <a href="https://www.webmd.com/drugs/drug-13700-irinotecan+iv.aspx">irinotecan</a> and <a href="https://www.webmd.com/drugs/drug-20983-imatinib+oral.aspx">imatinib</a>.</p><p>Always get your doctor's or pharmacist's OK before you try a new supplement. It's also possible for a medication you take to interact with a health condition you have. Some common drug-condition interactions happen between:</p><ul><li>Antacids and <a href="https://www.webmd.com/a-to-z-guides/understanding-kidney-disease-basic-information">kidney disease</a></li><li>Antihistamines and certain <a href="https://www.webmd.com/lung/breathing-problems-causes-tests-treatments">breathing problems</a>, <a href="https://www.webmd.com/eye-health/glaucoma-eyes">glaucoma</a>, <a href="https://webmd.com/men/prostate-enlargement-bph/default.htm">and enlarged prostate</a></li><li>Asthma rescue inhalers and conditions like <a href="https://www.webmd.com/heart-disease/default.htm">heart disease</a>, high blood pressure, <a href="https://www.webmd.com/women/guide/understanding-thyroid-problems-basics">thyroid</a> disease, and diabetes</li><li>Decongestants and conditions like heart disease, <a href="https://www.webmd.com/lung/coronavirus-high-blood-pressure">high blood pressure</a>, thyroid disease, and diabetes</li><li><a href="https://www.webmd.com/women/natural-sleep-remedies">Sleep aids</a> and certain <a href="https://www.webmd.com/lung/breathing-problems">breathing problems</a>, glaucoma, and enlarged prostate</li></ul></div></div></div><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-451" aria-describedby="webmd-collapse-content-451"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-451" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3> Is It OK to Take All Your Medications at Once?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-451" id="webmd-collapse-content-451"><div class="webmd-collapse-item__content"><p>It's important to take your medication as directed by your doctor or pharmacist. If two meds interact, spacing them apart during the day may not stop them from interacting and could lead to new or worse problems. To avoid an interaction, your doctor may need to change your dose or prescribe a different medication.</p></div></div></div><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-2415" aria-describedby="webmd-collapse-content-2415"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-2415" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3>What Are the Symptoms of a Drug Interaction?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-2415" id="webmd-collapse-content-2415"><div class="webmd-collapse-item__content"><p>The symptoms of a drug interaction can vary a lot, depending on the drugs you’re taking and how they’re interacting. Sometimes you might not even know right away that an interaction is happening.</p><p>If you do notice an interaction, it will usually feel like one of these is happening:</p><ul><li>You are having more side effects from a drug</li><li>Your drug doesn’t seem to be working as well as it was before</li></ul><p>In general, call your doctor if you're having side effects that worry you or if your medicine doesn't seem to be working, especially after you’ve recently started or changed doses of a drug.</p></div></div></div><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-7241" aria-describedby="webmd-collapse-content-7241"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-7241" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3>How Do Drug Interactions Happen?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-7241" id="webmd-collapse-content-7241"><div class="webmd-collapse-item__content"><p>There are several ways that drugs can interact with one another. Here are some examples of the most common ways.</p><p>When two drugs can cause the same side effect and are used at the same time, they might cause more of that side effect. For example, if two drugs can each make you sleepy, taking them together can make you more or dangerously sleepy.</p><p>When the unwanted effects of one drug are the opposite of the desired effects of another drug, you might end up with less of the desired effects. For example, taking one medication that raises blood pressure as an unwanted effect may decrease the benefits of taking another medication to lower your blood pressure.</p><p>Most drugs that you swallow enter your <a href="https://www.webmd.com/heart/anatomy-picture-of-blood">blood</a> through your <a href="https://www.webmd.com/digestive-disorders/picture-of-the-intestines">intestines</a>. Sometimes a drug or supplement can block or trap another drug in the intestine before it can be absorbed. For example, supplements like <a href="https://www.webmd.com/drugs/2/drug-1575/calcium+oral/details">calcium</a> and iron can prevent absorption of <a href="https://www.webmd.com/women/picture-of-the-thyroid">thyroid</a> meds.</p><p>Your body has enzymes, such as the cytochrome p450 (CYP) and others, that process many types of medications. This is called <a href="https://www.webmd.com/fitness-exercise/rm-quiz-truth-about-metabolism">metabolism</a>. It also has a way to get rid of drugs, usually though your <a href="https://www.webmd.com/urinary-incontinence-oab/truth-about-urine">urine</a>. Other drugs may speed up, slow down, or even completely block these functions. When this happens, the amount of drug in your body may increase (similar to taking too much) or decrease (similar to taking too little). Either way, this could cause serious problems.</p></div></div></div><div class="webmd-collapse-item is-active" style="margin:0 12px;"><div role="tab" aria-expanded="true" aria-controls="webmd-collapse-content-9789" aria-describedby="webmd-collapse-content-9789"><div class="webmd-collapse-item__header is-active" role="button" id="webmd-collapse-head-9789" tabindex="0"><i class="webmd-collapse-item__arrow webmd-icon-down-arrow is-active"></i><h3>How Do You Look for Drug Interactions?</h3></div></div><div class="webmd-collapse-item__wrap" role="tabpanel" aria-hidden="false" aria-labelledby="webmd-collapse-head-9789" id="webmd-collapse-content-9789"><div class="webmd-collapse-item__content"><p><b>Work closely with your doctor.</b> Make sure they know all the medicines, vitamins, and supplements you're taking. That's extra important if you have more than one doctor who prescribes medicines for you. You could show them a list of the meds you're taking, or bring the medication packages to your appointment.</p><p>Before you take a new drug, ask your doctor or pharmacist questions like:</p><ul><li>Can I take this with my other meds?</li><li>Should I avoid certain foods, drinks, or other products?</li><li>Could this medication interact with any health conditions I have?</li></ul><p>Pharmacists are experts on medicine safety, and they can work with your doctors to help you avoid drug interactions. For example, if you have two doctors and they separately prescribe drugs that interact, your pharmacist can warn them -- and you -- before you have a problem.</p><p><b>Read labels carefully.</b> Over-the-counter drug labels include information about possible drug interactions and the medication's active ingredients. Prescription medications usually come with a sheet that explains what the drug is and how to take it safely.</p><p>But most drug labels and patient handouts don't list every possible drug interaction. Talk to your pharmacist to get the full picture. They can also answer any questions about medical terms or jargon on the drug packages.</p></div></div></div></div></div></div><div class="view-ref-container"><a class="view-ref" tabindex="0"> View Sources</a><div class="pop-up" style="display:none;"><label class="ref-heading">SOURCES:</label><span class="close-popup"></span><div><p class="references">American Academy of Family Physicians: "The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects."</p><p class="references">FDA: "Drug Interactions: What You Should Know," "Mixing Medications and Dietary Supplements Can Endanger Your Health," "Grapefruit Juice and Some Drugs Don't Mix," "Why You Need to Take Your Medications as Prescribed or Instructed."</p><p class="references">Harvard: "7 things you can do to avoid drug interactions," "Bad mix: Blood thinners and NSAIDs," "How to talk to your doctor about medication."</p><p class="references">Medline: "Drug Reactions."</p><p class="references">National Institute on Alcohol Abuse and Alcoholism: "Mixing Alcohol With Medicines."</p><p class="references">American Heart Association: "Taking medicine for a cold? Be mindful of your heart."</p><p class="references">St. Luke's Health: "5 Harmful Medication Interactions You Need to Know."</p><p class="references">UC San Diego Health: "OTC Pain Medicines and Their Risks."</p><p class="references">CDC: "Get to Know Your Pharmacist."</p><p class="references">Medscape: "Dangerous and Deadly Drug Combinations."</p><p class="references">Cleveland Clinic: "How What You're Eating Could Be Affecting Your Medications," "Why Vitamin K Can Be Dangerous If You Take Warfarin," "General Medication Guidelines."</p><p class="references">FamilyDoctor.org: "Drug-Food Interactions."</p></div></div></div></div></div></div><div class="main-container main-container-3" tabindex="-1" data-js="main-container-3"><div class="webmd-row pane" style="" id="ContentPane37" tabindex="-1"><div class="ad-wrapper ad-container-121"><span></span></div></div><div class="webmd-row pane" style="" id="ContentPane39" tabindex="-1"><aside data-e2e="ed-urr" class="module 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