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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer - PMC
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name="description" content="TERT-locus single nucleotide polymorphisms (SNPs) and leucocyte telomere measures are reportedly associated with risks of multiple cancers. Using the iCOGs chip, we analysed ~480 TERT-locus SNPs in breast (n=103,991), ovarian (n=39,774) and BRCA1 ..."> <meta name="og:title" content="Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer"> <meta name="og:type" content="article"> <meta name="og:site_name" content="PubMed Central (PMC)"> <meta name="og:description" content="TERT-locus single nucleotide polymorphisms (SNPs) and leucocyte telomere measures are reportedly associated with risks of multiple cancers. 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Author manuscript; available in PMC: 2013 Oct 1.</div> <div> <em>Published in final edited form as: </em>Nat Genet. 2013 Apr;45(4):371–384e2. doi: <a href="https://doi.org/10.1038/ng.2566" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">10.1038/ng.2566</a> </div> <nav id="journal_context_menu" hidden="hidden"><ul class="menu-list font-family-ui" role="menu"> <li role="presentation"><a href="https://www.ncbi.nlm.nih.gov/pmc/?term=%22Nat%20Genet%22%5Bjour%5D" class="usa-link" role="menuitem">Search in PMC</a></li> <li role="presentation"><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nat%20Genet%22%5Bjour%5D" lang="en" class="usa-link" role="menuitem">Search in PubMed</a></li> <li role="presentation"><a href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Nat%20Genet%22%5BTitle%20Abbreviation%5D" class="usa-link" role="menuitem">View in NLM Catalog</a></li> <li role="presentation"><a href="?term=%22Nat%20Genet%22%5Bjour%5D" class="usa-link" role="menuitem" data-add-to-search="true">Add to search</a></li> </ul></nav></section><section class="front-matter"><div class="ameta p font-secondary font-xs"> <hgroup><h1>Multiple independent variants at the <em>TERT</em> locus are associated with telomere length and risks of breast and ovarian cancer</h1></hgroup><div class="cg p"> <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bojesen%20SE%22%5BAuthor%5D" class="usa-link" aria-describedby="id1"><span class="name western">Stig E Bojesen</span></a><div hidden="hidden" id="id1"> <h3><span class="name western">Stig E Bojesen</span></h3> <div class="p"> <sup>1</sup>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p"> <sup>2</sup>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bojesen%20SE%22%5BAuthor%5D" class="usa-link"><span class="name western">Stig E Bojesen</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>*</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pooley%20KA%22%5BAuthor%5D" class="usa-link" aria-describedby="id2"><span class="name western">Karen A Pooley</span></a><div hidden="hidden" id="id2"> <h3><span class="name western">Karen A Pooley</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pooley%20KA%22%5BAuthor%5D" class="usa-link"><span class="name western">Karen A Pooley</span></a> </div> </div> <sup>3,</sup><sup>*</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Johnatty%20SE%22%5BAuthor%5D" class="usa-link" aria-describedby="id3"><span class="name western">Sharon E Johnatty</span></a><div hidden="hidden" id="id3"> <h3><span class="name western">Sharon E Johnatty</span></h3> <div class="p"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Johnatty%20SE%22%5BAuthor%5D" class="usa-link"><span class="name western">Sharon E Johnatty</span></a> </div> </div> <sup>4,</sup><sup>*</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Beesley%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id4"><span class="name western">Jonathan Beesley</span></a><div hidden="hidden" id="id4"> <h3><span class="name western">Jonathan Beesley</span></h3> <div class="p"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Beesley%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jonathan Beesley</span></a> </div> </div> <sup>4,</sup><sup>*</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Michailidou%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id5"><span class="name western">Kyriaki Michailidou</span></a><div hidden="hidden" id="id5"> <h3><span class="name western">Kyriaki Michailidou</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Michailidou%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kyriaki Michailidou</span></a> </div> </div> <sup>3,</sup><sup>*</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tyrer%20JP%22%5BAuthor%5D" class="usa-link" aria-describedby="id6"><span class="name western">Jonathan P Tyrer</span></a><div hidden="hidden" id="id6"> <h3><span class="name western">Jonathan P Tyrer</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tyrer%20JP%22%5BAuthor%5D" class="usa-link"><span class="name western">Jonathan P Tyrer</span></a> </div> </div> <sup>5,</sup><sup>*</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Edwards%20SL%22%5BAuthor%5D" class="usa-link" aria-describedby="id7"><span class="name western">Stacey L Edwards</span></a><div hidden="hidden" id="id7"> <h3><span class="name western">Stacey L Edwards</span></h3> <div class="p"> <sup>6</sup>School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Edwards%20SL%22%5BAuthor%5D" class="usa-link"><span class="name western">Stacey L Edwards</span></a> </div> </div> <sup>6</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pickett%20HA%22%5BAuthor%5D" class="usa-link" aria-describedby="id8"><span class="name western">Hilda A Pickett</span></a><div hidden="hidden" id="id8"> <h3><span class="name western">Hilda A Pickett</span></h3> <div class="p"> <sup>7</sup>Cancer Research Unit, Children's Medical Research Institute, Westmead, NSW, Australia</div> <div class="p"> <sup>8</sup>Sydney Medical School, University of Sydney, Sydney, NSW, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pickett%20HA%22%5BAuthor%5D" class="usa-link"><span class="name western">Hilda A Pickett</span></a> </div> </div> <sup>7,</sup><sup>8</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shen%20HC%22%5BAuthor%5D" class="usa-link" aria-describedby="id9"><span class="name western">Howard C Shen</span></a><div hidden="hidden" id="id9"> <h3><span class="name western">Howard C Shen</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shen%20HC%22%5BAuthor%5D" class="usa-link"><span class="name western">Howard C Shen</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Smart%20CE%22%5BAuthor%5D" class="usa-link" aria-describedby="id10"><span class="name western">Chanel E Smart</span></a><div hidden="hidden" id="id10"> <h3><span class="name western">Chanel E Smart</span></h3> <div class="p"> <sup>10</sup>University of Queensland, UQ Centre for Clinical Research (UQCCR) Royal Brisbane and Women's Hospital, Herston, QLD, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Smart%20CE%22%5BAuthor%5D" class="usa-link"><span class="name western">Chanel E Smart</span></a> </div> </div> <sup>10</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hillman%20KM%22%5BAuthor%5D" class="usa-link" aria-describedby="id11"><span class="name western">Kristine M Hillman</span></a><div hidden="hidden" id="id11"> <h3><span class="name western">Kristine M Hillman</span></h3> <div class="p"> <sup>6</sup>School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hillman%20KM%22%5BAuthor%5D" class="usa-link"><span class="name western">Kristine M Hillman</span></a> </div> </div> <sup>6</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mai%20PL%22%5BAuthor%5D" class="usa-link" aria-describedby="id12"><span class="name western">Phuong L Mai</span></a><div hidden="hidden" id="id12"> <h3><span class="name western">Phuong L Mai</span></h3> <div class="p"> <sup>11</sup>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mai%20PL%22%5BAuthor%5D" class="usa-link"><span class="name western">Phuong L Mai</span></a> </div> </div> <sup>11</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lawrenson%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id13"><span class="name western">Kate Lawrenson</span></a><div hidden="hidden" id="id13"> <h3><span class="name western">Kate Lawrenson</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lawrenson%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kate Lawrenson</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stutz%20MD%22%5BAuthor%5D" class="usa-link" aria-describedby="id14"><span class="name western">Michael D Stutz</span></a><div hidden="hidden" id="id14"> <h3><span class="name western">Michael D Stutz</span></h3> <div class="p"> <sup>7</sup>Cancer Research Unit, Children's Medical Research Institute, Westmead, NSW, Australia</div> <div class="p"> <sup>8</sup>Sydney Medical School, University of Sydney, Sydney, NSW, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stutz%20MD%22%5BAuthor%5D" class="usa-link"><span class="name western">Michael D Stutz</span></a> </div> </div> <sup>7,</sup><sup>8</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lu%20Y%22%5BAuthor%5D" class="usa-link" aria-describedby="id15"><span class="name western">Yi Lu</span></a><div hidden="hidden" id="id15"> <h3><span class="name western">Yi Lu</span></h3> <div class="p"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lu%20Y%22%5BAuthor%5D" class="usa-link"><span class="name western">Yi Lu</span></a> </div> </div> <sup>4</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Karevan%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id16"><span class="name western">Rod Karevan</span></a><div hidden="hidden" id="id16"> <h3><span class="name western">Rod Karevan</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Karevan%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Rod Karevan</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Woods%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id17"><span class="name western">Nicholas Woods</span></a><div hidden="hidden" id="id17"> <h3><span class="name western">Nicholas Woods</span></h3> <div class="p"> <sup>12</sup>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Woods%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nicholas Woods</span></a> </div> </div> <sup>12</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Johnston%20RL%22%5BAuthor%5D" class="usa-link" aria-describedby="id18"><span class="name western">Rebecca L Johnston</span></a><div hidden="hidden" id="id18"> <h3><span class="name western">Rebecca L Johnston</span></h3> <div class="p"> <sup>10</sup>University of Queensland, UQ Centre for Clinical Research (UQCCR) Royal Brisbane and Women's Hospital, Herston, QLD, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Johnston%20RL%22%5BAuthor%5D" class="usa-link"><span class="name western">Rebecca L Johnston</span></a> </div> </div> <sup>10</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22French%20JD%22%5BAuthor%5D" class="usa-link" aria-describedby="id19"><span class="name western">Juliet D French</span></a><div hidden="hidden" id="id19"> <h3><span class="name western">Juliet D French</span></h3> <div class="p"> <sup>6</sup>School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22French%20JD%22%5BAuthor%5D" class="usa-link"><span class="name western">Juliet D French</span></a> </div> </div> <sup>6</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chen%20X%22%5BAuthor%5D" class="usa-link" aria-describedby="id20"><span class="name western">Xiaoqing Chen</span></a><div hidden="hidden" id="id20"> <h3><span class="name western">Xiaoqing Chen</span></h3> <div class="p"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chen%20X%22%5BAuthor%5D" class="usa-link"><span class="name western">Xiaoqing Chen</span></a> </div> </div> <sup>4</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Weischer%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id21"><span class="name western">Maren Weischer</span></a><div hidden="hidden" id="id21"> <h3><span class="name western">Maren Weischer</span></h3> <div class="p"> <sup>1</sup>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p"> <sup>2</sup>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Weischer%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Maren Weischer</span></a> </div> </div> <sup>1,</sup><sup>2</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nielsen%20SF%22%5BAuthor%5D" class="usa-link" aria-describedby="id22"><span class="name western">Sune F Nielsen</span></a><div hidden="hidden" id="id22"> <h3><span class="name western">Sune F Nielsen</span></h3> <div class="p"> <sup>1</sup>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p"> <sup>2</sup>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nielsen%20SF%22%5BAuthor%5D" class="usa-link"><span class="name western">Sune F Nielsen</span></a> </div> </div> <sup>1,</sup><sup>2</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Maranian%20MJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id23"><span class="name western">Melanie J Maranian</span></a><div hidden="hidden" id="id23"> <h3><span class="name western">Melanie J Maranian</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Maranian%20MJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Melanie J Maranian</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ghoussaini%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id24"><span class="name western">Maya Ghoussaini</span></a><div hidden="hidden" id="id24"> <h3><span class="name western">Maya Ghoussaini</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ghoussaini%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Maya Ghoussaini</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ahmed%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id25"><span class="name western">Shahana Ahmed</span></a><div hidden="hidden" id="id25"> <h3><span class="name western">Shahana Ahmed</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ahmed%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Shahana Ahmed</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Baynes%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id26"><span class="name western">Caroline Baynes</span></a><div hidden="hidden" id="id26"> <h3><span class="name western">Caroline Baynes</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Baynes%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Caroline Baynes</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bolla%20MK%22%5BAuthor%5D" class="usa-link" aria-describedby="id27"><span class="name western">Manjeet K Bolla</span></a><div hidden="hidden" id="id27"> <h3><span class="name western">Manjeet K Bolla</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bolla%20MK%22%5BAuthor%5D" class="usa-link"><span class="name western">Manjeet K Bolla</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang%20Q%22%5BAuthor%5D" class="usa-link" aria-describedby="id28"><span class="name western">Qin Wang</span></a><div hidden="hidden" id="id28"> <h3><span class="name western">Qin Wang</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang%20Q%22%5BAuthor%5D" class="usa-link"><span class="name western">Qin Wang</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dennis%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id29"><span class="name western">Joe Dennis</span></a><div hidden="hidden" id="id29"> <h3><span class="name western">Joe Dennis</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dennis%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Joe Dennis</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McGuffog%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id30"><span class="name western">Lesley McGuffog</span></a><div hidden="hidden" id="id30"> <h3><span class="name western">Lesley McGuffog</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McGuffog%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Lesley McGuffog</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Barrowdale%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id31"><span class="name western">Daniel Barrowdale</span></a><div hidden="hidden" id="id31"> <h3><span class="name western">Daniel Barrowdale</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Barrowdale%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Daniel Barrowdale</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lee%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id32"><span class="name western">Andrew Lee</span></a><div hidden="hidden" id="id32"> <h3><span class="name western">Andrew Lee</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lee%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Andrew Lee</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Healey%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id33"><span class="name western">Sue Healey</span></a><div hidden="hidden" id="id33"> <h3><span class="name western">Sue Healey</span></h3> <div class="p"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Healey%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Sue Healey</span></a> </div> </div> <sup>4</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lush%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id34"><span class="name western">Michael Lush</span></a><div hidden="hidden" id="id34"> <h3><span class="name western">Michael Lush</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lush%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Michael Lush</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tessier%20DC%22%5BAuthor%5D" class="usa-link" aria-describedby="id35"><span class="name western">Daniel C Tessier</span></a><div hidden="hidden" id="id35"> <h3><span class="name western">Daniel C Tessier</span></h3> <div class="p"> <sup>13</sup>McGill University, Montréal, QC, Canada</div> <div class="p"> <sup>14</sup>Génome Québec Innovation Centre, Montréal, QC, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tessier%20DC%22%5BAuthor%5D" class="usa-link"><span class="name western">Daniel C Tessier</span></a> </div> </div> <sup>13,</sup><sup>14</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vincent%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id36"><span class="name western">Daniel Vincent</span></a><div hidden="hidden" id="id36"> <h3><span class="name western">Daniel Vincent</span></h3> <div class="p"> <sup>13</sup>McGill University, Montréal, QC, Canada</div> <div class="p"> <sup>14</sup>Génome Québec Innovation Centre, Montréal, QC, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vincent%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Daniel Vincent</span></a> </div> </div> <sup>13,</sup><sup>14</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bacot%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id37"><span class="name western">Françis Bacot</span></a><div hidden="hidden" id="id37"> <h3><span class="name western">Françis Bacot</span></h3> <div class="p"> <sup>13</sup>McGill University, Montréal, QC, Canada</div> <div class="p"> <sup>14</sup>Génome Québec Innovation Centre, Montréal, QC, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bacot%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">Françis Bacot</span></a> </div> </div> <sup>13,</sup><sup>14</sup>; <span class="collab">Study Group members</span><sup>15</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vergote%20I%22%5BAuthor%5D" class="usa-link" aria-describedby="id38"><span class="name western">Ignace Vergote</span></a><div hidden="hidden" id="id38"> <h3><span class="name western">Ignace Vergote</span></h3> <div class="p"> <sup>16</sup>Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium</div> <div class="p"> <sup>17</sup>Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vergote%20I%22%5BAuthor%5D" class="usa-link"><span class="name western">Ignace Vergote</span></a> </div> </div> <sup>16,</sup><sup>17</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lambrechts%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id39"><span class="name western">Sandrina Lambrechts</span></a><div hidden="hidden" id="id39"> <h3><span class="name western">Sandrina Lambrechts</span></h3> <div class="p"> <sup>16</sup>Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium</div> <div class="p"> <sup>17</sup>Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lambrechts%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Sandrina Lambrechts</span></a> </div> </div> <sup>16,</sup><sup>17</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Despierre%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id40"><span class="name western">Evelyn Despierre</span></a><div hidden="hidden" id="id40"> <h3><span class="name western">Evelyn Despierre</span></h3> <div class="p"> <sup>16</sup>Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium</div> <div class="p"> <sup>17</sup>Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Despierre%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Evelyn Despierre</span></a> </div> </div> <sup>16,</sup><sup>17</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Risch%20HA%22%5BAuthor%5D" class="usa-link" aria-describedby="id41"><span class="name western">Harvey A Risch</span></a><div hidden="hidden" id="id41"> <h3><span class="name western">Harvey A Risch</span></h3> <div class="p"> <sup>18</sup>Department of Epidemiology and Public Health, Yale University School of Public Health and School of Medicine, New Haven, CT, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Risch%20HA%22%5BAuthor%5D" class="usa-link"><span class="name western">Harvey A Risch</span></a> </div> </div> <sup>18</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gonz%C3%A1lez-Neira%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id42"><span class="name western">Anna González-Neira</span></a><div hidden="hidden" id="id42"> <h3><span class="name western">Anna González-Neira</span></h3> <div class="p"> <sup>19</sup>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gonz%C3%A1lez-Neira%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Anna González-Neira</span></a> </div> </div> <sup>19</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rossing%20MA%22%5BAuthor%5D" class="usa-link" aria-describedby="id43"><span class="name western">Mary Anne Rossing</span></a><div hidden="hidden" id="id43"> <h3><span class="name western">Mary Anne Rossing</span></h3> <div class="p"> <sup>20</sup>Department of Epidemiology, University of Washington, Seattle, WA, USA</div> <div class="p"> <sup>21</sup>Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rossing%20MA%22%5BAuthor%5D" class="usa-link"><span class="name western">Mary Anne Rossing</span></a> </div> </div> <sup>20,</sup><sup>21</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pita%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id44"><span class="name western">Guillermo Pita</span></a><div hidden="hidden" id="id44"> <h3><span class="name western">Guillermo Pita</span></h3> <div class="p"> <sup>19</sup>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pita%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">Guillermo Pita</span></a> </div> </div> <sup>19</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Doherty%20JA%22%5BAuthor%5D" class="usa-link" aria-describedby="id45"><span class="name western">Jennifer A Doherty</span></a><div hidden="hidden" id="id45"> <h3><span class="name western">Jennifer A Doherty</span></h3> <div class="p"> <sup>22</sup>Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Doherty%20JA%22%5BAuthor%5D" class="usa-link"><span class="name western">Jennifer A Doherty</span></a> </div> </div> <sup>22</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22%C3%81lvarez%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id46"><span class="name western">Nuria Álvarez</span></a><div hidden="hidden" id="id46"> <h3><span class="name western">Nuria Álvarez</span></h3> <div class="p"> <sup>19</sup>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22%C3%81lvarez%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nuria Álvarez</span></a> </div> </div> <sup>19</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Larson%20MC%22%5BAuthor%5D" class="usa-link" aria-describedby="id47"><span class="name western">Melissa C Larson</span></a><div hidden="hidden" id="id47"> <h3><span class="name western">Melissa C Larson</span></h3> <div class="p"> <sup>23</sup>Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Larson%20MC%22%5BAuthor%5D" class="usa-link"><span class="name western">Melissa C Larson</span></a> </div> </div> <sup>23</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fridley%20BL%22%5BAuthor%5D" class="usa-link" aria-describedby="id48"><span class="name western">Brooke L Fridley</span></a><div hidden="hidden" id="id48"> <h3><span class="name western">Brooke L Fridley</span></h3> <div class="p"> <sup>23</sup>Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fridley%20BL%22%5BAuthor%5D" class="usa-link"><span class="name western">Brooke L Fridley</span></a> </div> </div> <sup>23</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schoof%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id49"><span class="name western">Nils Schoof</span></a><div hidden="hidden" id="id49"> <h3><span class="name western">Nils Schoof</span></h3> <div class="p"> <sup>24</sup>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schoof%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nils Schoof</span></a> </div> </div> <sup>24</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chang-Claude%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id50"><span class="name western">Jenny Chang-Claude</span></a><div hidden="hidden" id="id50"> <h3><span class="name western">Jenny Chang-Claude</span></h3> <div class="p"> <sup>25</sup>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chang-Claude%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jenny Chang-Claude</span></a> </div> </div> <sup>25</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cicek%20MS%22%5BAuthor%5D" class="usa-link" aria-describedby="id51"><span class="name western">Mine S Cicek</span></a><div hidden="hidden" id="id51"> <h3><span class="name western">Mine S Cicek</span></h3> <div class="p"> <sup>26</sup>Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cicek%20MS%22%5BAuthor%5D" class="usa-link"><span class="name western">Mine S Cicek</span></a> </div> </div> <sup>26</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peto%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id52"><span class="name western">Julian Peto</span></a><div hidden="hidden" id="id52"> <h3><span class="name western">Julian Peto</span></h3> <div class="p"> <sup>27</sup>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peto%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Julian Peto</span></a> </div> </div> <sup>27</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kalli%20KR%22%5BAuthor%5D" class="usa-link" aria-describedby="id53"><span class="name western">Kimberly R Kalli</span></a><div hidden="hidden" id="id53"> <h3><span class="name western">Kimberly R Kalli</span></h3> <div class="p"> <sup>28</sup>Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kalli%20KR%22%5BAuthor%5D" class="usa-link"><span class="name western">Kimberly R Kalli</span></a> </div> </div> <sup>28</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Broeks%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id54"><span class="name western">Annegien Broeks</span></a><div hidden="hidden" id="id54"> <h3><span class="name western">Annegien Broeks</span></h3> <div class="p"> <sup>29</sup>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Broeks%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Annegien Broeks</span></a> </div> </div> <sup>29</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Armasu%20SM%22%5BAuthor%5D" class="usa-link" aria-describedby="id55"><span class="name western">Sebastian M Armasu</span></a><div hidden="hidden" id="id55"> <h3><span class="name western">Sebastian M Armasu</span></h3> <div class="p"> <sup>23</sup>Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Armasu%20SM%22%5BAuthor%5D" class="usa-link"><span class="name western">Sebastian M Armasu</span></a> </div> </div> <sup>23</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schmidt%20MK%22%5BAuthor%5D" class="usa-link" aria-describedby="id56"><span class="name western">Marjanka K Schmidt</span></a><div hidden="hidden" id="id56"> <h3><span class="name western">Marjanka K Schmidt</span></h3> <div class="p"> <sup>29</sup>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div class="p"> <sup>30</sup>Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schmidt%20MK%22%5BAuthor%5D" class="usa-link"><span class="name western">Marjanka K Schmidt</span></a> </div> </div> <sup>29,</sup><sup>30</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Braaf%20LM%22%5BAuthor%5D" class="usa-link" aria-describedby="id57"><span class="name western">Linde M Braaf</span></a><div hidden="hidden" id="id57"> <h3><span class="name western">Linde M Braaf</span></h3> <div class="p"> <sup>29</sup>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Braaf%20LM%22%5BAuthor%5D" class="usa-link"><span class="name western">Linde M Braaf</span></a> </div> </div> <sup>29</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Winterhoff%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id58"><span class="name western">Boris Winterhoff</span></a><div hidden="hidden" id="id58"> <h3><span class="name western">Boris Winterhoff</span></h3> <div class="p"> <sup>31</sup>Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Winterhoff%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Boris Winterhoff</span></a> </div> </div> <sup>31</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nevanlinna%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id59"><span class="name western">Heli Nevanlinna</span></a><div hidden="hidden" id="id59"> <h3><span class="name western">Heli Nevanlinna</span></h3> <div class="p"> <sup>32</sup>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nevanlinna%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Heli Nevanlinna</span></a> </div> </div> <sup>32</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Konecny%20GE%22%5BAuthor%5D" class="usa-link" aria-describedby="id60"><span class="name western">Gottfried E Konecny</span></a><div hidden="hidden" id="id60"> <h3><span class="name western">Gottfried E Konecny</span></h3> <div class="p"> <sup>33</sup>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Konecny%20GE%22%5BAuthor%5D" class="usa-link"><span class="name western">Gottfried E Konecny</span></a> </div> </div> <sup>33</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lambrechts%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id61"><span class="name western">Diether Lambrechts</span></a><div hidden="hidden" id="id61"> <h3><span class="name western">Diether Lambrechts</span></h3> <div class="p"> <sup>34</sup>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium</div> <div class="p"> <sup>35</sup>Vesalius Research Center (VRC), VIB, Leuven, Belgium</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lambrechts%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Diether Lambrechts</span></a> </div> </div> <sup>34,</sup><sup>35</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rogmann%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id62"><span class="name western">Lisa Rogmann</span></a><div hidden="hidden" id="id62"> <h3><span class="name western">Lisa Rogmann</span></h3> <div class="p"> <sup>31</sup>Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rogmann%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Lisa Rogmann</span></a> </div> </div> <sup>31</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gu%C3%A9nel%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id63"><span class="name western">Pascal Guénel</span></a><div hidden="hidden" id="id63"> <h3><span class="name western">Pascal Guénel</span></h3> <div class="p"> <sup>36</sup>INSERM U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France</div> <div class="p"> <sup>37</sup>University Paris-Sud, UMRS 1018, Villejuif, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gu%C3%A9nel%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Pascal Guénel</span></a> </div> </div> <sup>36,</sup><sup>37</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teoman%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id64"><span class="name western">Attila Teoman</span></a><div hidden="hidden" id="id64"> <h3><span class="name western">Attila Teoman</span></h3> <div class="p"> <sup>31</sup>Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teoman%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Attila Teoman</span></a> </div> </div> <sup>31</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Milne%20RL%22%5BAuthor%5D" class="usa-link" aria-describedby="id65"><span class="name western">Roger L Milne</span></a><div hidden="hidden" id="id65"> <h3><span class="name western">Roger L Milne</span></h3> <div class="p"> <sup>38</sup>Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Milne%20RL%22%5BAuthor%5D" class="usa-link"><span class="name western">Roger L Milne</span></a> </div> </div> <sup>38</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Garcia%20JJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id66"><span class="name western">Joaquin J Garcia</span></a><div hidden="hidden" id="id66"> <h3><span class="name western">Joaquin J Garcia</span></h3> <div class="p"> <sup>39</sup>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Garcia%20JJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Joaquin J Garcia</span></a> </div> </div> <sup>39</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cox%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id67"><span class="name western">Angela Cox</span></a><div hidden="hidden" id="id67"> <h3><span class="name western">Angela Cox</span></h3> <div class="p"> <sup>40</sup>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cox%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Angela Cox</span></a> </div> </div> <sup>40</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shridhar%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id68"><span class="name western">Vijayalakshmi Shridhar</span></a><div hidden="hidden" id="id68"> <h3><span class="name western">Vijayalakshmi Shridhar</span></h3> <div class="p"> <sup>39</sup>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shridhar%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Vijayalakshmi Shridhar</span></a> </div> </div> <sup>39</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Burwinkel%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id69"><span class="name western">Barbara Burwinkel</span></a><div hidden="hidden" id="id69"> <h3><span class="name western">Barbara Burwinkel</span></h3> <div class="p"> <sup>41</sup>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</div> <div class="p"> <sup>42</sup>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Burwinkel%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Barbara Burwinkel</span></a> </div> </div> <sup>41,</sup><sup>42</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Marme%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id70"><span class="name western">Frederik Marme</span></a><div hidden="hidden" id="id70"> <h3><span class="name western">Frederik Marme</span></h3> <div class="p"> <sup>41</sup>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</div> <div class="p"> <sup>43</sup>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Marme%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">Frederik Marme</span></a> </div> </div> <sup>41,</sup><sup>43</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hein%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id71"><span class="name western">Rebecca Hein</span></a><div hidden="hidden" id="id71"> <h3><span class="name western">Rebecca Hein</span></h3> <div class="p"> <sup>25</sup>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div class="p"> <sup>44</sup>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hein%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Rebecca Hein</span></a> </div> </div> <sup>25,</sup><sup>44</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sawyer%20EJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id72"><span class="name western">Elinor J Sawyer</span></a><div hidden="hidden" id="id72"> <h3><span class="name western">Elinor J Sawyer</span></h3> <div class="p"> <sup>45</sup>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sawyer%20EJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Elinor J Sawyer</span></a> </div> </div> <sup>45</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Haiman%20CA%22%5BAuthor%5D" class="usa-link" aria-describedby="id73"><span class="name western">Christopher A Haiman</span></a><div hidden="hidden" id="id73"> <h3><span class="name western">Christopher A Haiman</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Haiman%20CA%22%5BAuthor%5D" class="usa-link"><span class="name western">Christopher A Haiman</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang-Gohrke%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id74"><span class="name western">Shan Wang-Gohrke</span></a><div hidden="hidden" id="id74"> <h3><span class="name western">Shan Wang-Gohrke</span></h3> <div class="p"> <sup>46</sup>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang-Gohrke%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Shan Wang-Gohrke</span></a> </div> </div> <sup>46</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Andrulis%20IL%22%5BAuthor%5D" class="usa-link" aria-describedby="id75"><span class="name western">Irene L Andrulis</span></a><div hidden="hidden" id="id75"> <h3><span class="name western">Irene L Andrulis</span></h3> <div class="p"> <sup>47</sup>Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</div> <div class="p"> <sup>48</sup>Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Andrulis%20IL%22%5BAuthor%5D" class="usa-link"><span class="name western">Irene L Andrulis</span></a> </div> </div> <sup>47,</sup><sup>48</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moysich%20KB%22%5BAuthor%5D" class="usa-link" aria-describedby="id76"><span class="name western">Kirsten B Moysich</span></a><div hidden="hidden" id="id76"> <h3><span class="name western">Kirsten B Moysich</span></h3> <div class="p"> <sup>49</sup>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Moysich%20KB%22%5BAuthor%5D" class="usa-link"><span class="name western">Kirsten B Moysich</span></a> </div> </div> <sup>49</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hopper%20JL%22%5BAuthor%5D" class="usa-link" aria-describedby="id77"><span class="name western">John L Hopper</span></a><div hidden="hidden" id="id77"> <h3><span class="name western">John L Hopper</span></h3> <div class="p"> <sup>50</sup>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hopper%20JL%22%5BAuthor%5D" class="usa-link"><span class="name western">John L Hopper</span></a> </div> </div> <sup>50</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Odunsi%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id78"><span class="name western">Kunle Odunsi</span></a><div hidden="hidden" id="id78"> <h3><span class="name western">Kunle Odunsi</span></h3> <div class="p"> <sup>49</sup>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Odunsi%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kunle Odunsi</span></a> </div> </div> <sup>49</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lindblom%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id79"><span class="name western">Annika Lindblom</span></a><div hidden="hidden" id="id79"> <h3><span class="name western">Annika Lindblom</span></h3> <div class="p"> <sup>51</sup>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lindblom%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Annika Lindblom</span></a> </div> </div> <sup>51</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giles%20GG%22%5BAuthor%5D" class="usa-link" aria-describedby="id80"><span class="name western">Graham G Giles</span></a><div hidden="hidden" id="id80"> <h3><span class="name western">Graham G Giles</span></h3> <div class="p"> <sup>50</sup>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia</div> <div class="p"> <sup>52</sup>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia</div> <div class="p"> <sup>53</sup>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giles%20GG%22%5BAuthor%5D" class="usa-link"><span class="name western">Graham G Giles</span></a> </div> </div> <sup>50,</sup><sup>52,</sup><sup>53</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brenner%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id81"><span class="name western">Hermann Brenner</span></a><div hidden="hidden" id="id81"> <h3><span class="name western">Hermann Brenner</span></h3> <div class="p"> <sup>54</sup>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brenner%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hermann Brenner</span></a> </div> </div> <sup>54</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Simard%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id82"><span class="name western">Jacques Simard</span></a><div hidden="hidden" id="id82"> <h3><span class="name western">Jacques Simard</span></h3> <div class="p"> <sup>55</sup>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Simard%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jacques Simard</span></a> </div> </div> <sup>55</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lurie%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id83"><span class="name western">Galina Lurie</span></a><div hidden="hidden" id="id83"> <h3><span class="name western">Galina Lurie</span></h3> <div class="p"> <sup>56</sup>Cancer Epidemiology Program, University of Hawaii Cancer Center, HI, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lurie%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">Galina Lurie</span></a> </div> </div> <sup>56</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fasching%20PA%22%5BAuthor%5D" class="usa-link" aria-describedby="id84"><span class="name western">Peter A Fasching</span></a><div hidden="hidden" id="id84"> <h3><span class="name western">Peter A Fasching</span></h3> <div class="p"> <sup>33</sup>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA</div> <div class="p"> <sup>57</sup>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fasching%20PA%22%5BAuthor%5D" class="usa-link"><span class="name western">Peter A Fasching</span></a> </div> </div> <sup>33,</sup><sup>57</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carney%20ME%22%5BAuthor%5D" class="usa-link" aria-describedby="id85"><span class="name western">Michael E Carney</span></a><div hidden="hidden" id="id85"> <h3><span class="name western">Michael E Carney</span></h3> <div class="p"> <sup>56</sup>Cancer Epidemiology Program, University of Hawaii Cancer Center, HI, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Carney%20ME%22%5BAuthor%5D" class="usa-link"><span class="name western">Michael E Carney</span></a> </div> </div> <sup>56</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Radice%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id86"><span class="name western">Paolo Radice</span></a><div hidden="hidden" id="id86"> <h3><span class="name western">Paolo Radice</span></h3> <div class="p"> <sup>58</sup>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</div> <div class="p"> <sup>59</sup>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Radice%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Paolo Radice</span></a> </div> </div> <sup>58,</sup><sup>59</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilkens%20LR%22%5BAuthor%5D" class="usa-link" aria-describedby="id87"><span class="name western">Lynne R Wilkens</span></a><div hidden="hidden" id="id87"> <h3><span class="name western">Lynne R Wilkens</span></h3> <div class="p"> <sup>56</sup>Cancer Epidemiology Program, University of Hawaii Cancer Center, HI, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wilkens%20LR%22%5BAuthor%5D" class="usa-link"><span class="name western">Lynne R Wilkens</span></a> </div> </div> <sup>56</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Swerdlow%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id88"><span class="name western">Anthony Swerdlow</span></a><div hidden="hidden" id="id88"> <h3><span class="name western">Anthony Swerdlow</span></h3> <div class="p"> <sup>60</sup>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK</div> <div class="p"> <sup>61</sup>Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Swerdlow%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Anthony Swerdlow</span></a> </div> </div> <sup>60,</sup><sup>61</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goodman%20MT%22%5BAuthor%5D" class="usa-link" aria-describedby="id89"><span class="name western">Marc T Goodman</span></a><div hidden="hidden" id="id89"> <h3><span class="name western">Marc T Goodman</span></h3> <div class="p"> <sup>62</sup>Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goodman%20MT%22%5BAuthor%5D" class="usa-link"><span class="name western">Marc T Goodman</span></a> </div> </div> <sup>62</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brauch%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id90"><span class="name western">Hiltrud Brauch</span></a><div hidden="hidden" id="id90"> <h3><span class="name western">Hiltrud Brauch</span></h3> <div class="p"> <sup>63</sup>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</div> <div class="p"> <sup>64</sup>University of Tübingen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brauch%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hiltrud Brauch</span></a> </div> </div> <sup>63,</sup><sup>64</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Garc%C3%ADa-Closas%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id91"><span class="name western">Montserrat García-Closas</span></a><div hidden="hidden" id="id91"> <h3><span class="name western">Montserrat García-Closas</span></h3> <div class="p"> <sup>65</sup>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Garc%C3%ADa-Closas%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Montserrat García-Closas</span></a> </div> </div> <sup>65</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hillemanns%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id92"><span class="name western">Peter Hillemanns</span></a><div hidden="hidden" id="id92"> <h3><span class="name western">Peter Hillemanns</span></h3> <div class="p"> <sup>66</sup>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hillemanns%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Peter Hillemanns</span></a> </div> </div> <sup>66</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Winqvist%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id93"><span class="name western">Robert Winqvist</span></a><div hidden="hidden" id="id93"> <h3><span class="name western">Robert Winqvist</span></h3> <div class="p"> <sup>67</sup>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland</div> <div class="p"> <sup>68</sup>Biocenter Oulu, University of Oulu, Oulu, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Winqvist%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Robert Winqvist</span></a> </div> </div> <sup>67,</sup><sup>68</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22D%C3%BCrst%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id94"><span class="name western">Matthias Dürst</span></a><div hidden="hidden" id="id94"> <h3><span class="name western">Matthias Dürst</span></h3> <div class="p"> <sup>69</sup>Department of Gynecology, Jena University Hospital, Jena, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22D%C3%BCrst%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Matthias Dürst</span></a> </div> </div> <sup>69</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Devilee%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id95"><span class="name western">Peter Devilee</span></a><div hidden="hidden" id="id95"> <h3><span class="name western">Peter Devilee</span></h3> <div class="p"> <sup>70</sup>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</div> <div class="p"> <sup>71</sup>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Devilee%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Peter Devilee</span></a> </div> </div> <sup>70,</sup><sup>71</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Runnebaum%20I%22%5BAuthor%5D" class="usa-link" aria-describedby="id96"><span class="name western">Ingo Runnebaum</span></a><div hidden="hidden" id="id96"> <h3><span class="name western">Ingo Runnebaum</span></h3> <div class="p"> <sup>69</sup>Department of Gynecology, Jena University Hospital, Jena, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Runnebaum%20I%22%5BAuthor%5D" class="usa-link"><span class="name western">Ingo Runnebaum</span></a> </div> </div> <sup>69</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jakubowska%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id97"><span class="name western">Anna Jakubowska</span></a><div hidden="hidden" id="id97"> <h3><span class="name western">Anna Jakubowska</span></h3> <div class="p"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jakubowska%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Anna Jakubowska</span></a> </div> </div> <sup>72</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lubinski%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id98"><span class="name western">Jan Lubinski</span></a><div hidden="hidden" id="id98"> <h3><span class="name western">Jan Lubinski</span></h3> <div class="p"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lubinski%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jan Lubinski</span></a> </div> </div> <sup>72</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mannermaa%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id99"><span class="name western">Arto Mannermaa</span></a><div hidden="hidden" id="id99"> <h3><span class="name western">Arto Mannermaa</span></h3> <div class="p"> <sup>73</sup>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</div> <div class="p"> <sup>74</sup>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mannermaa%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Arto Mannermaa</span></a> </div> </div> <sup>73,</sup><sup>74</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Butzow%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id100"><span class="name western">Ralf Butzow</span></a><div hidden="hidden" id="id100"> <h3><span class="name western">Ralf Butzow</span></h3> <div class="p"> <sup>32</sup>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div class="p"> <sup>75</sup>Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Butzow%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Ralf Butzow</span></a> </div> </div> <sup>32,</sup><sup>75</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bogdanova%20NV%22%5BAuthor%5D" class="usa-link" aria-describedby="id101"><span class="name western">Natalia V Bogdanova</span></a><div hidden="hidden" id="id101"> <h3><span class="name western">Natalia V Bogdanova</span></h3> <div class="p"> <sup>76</sup>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</div> <div class="p"> <sup>77</sup>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bogdanova%20NV%22%5BAuthor%5D" class="usa-link"><span class="name western">Natalia V Bogdanova</span></a> </div> </div> <sup>76,</sup><sup>77</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22D%C3%B6rk%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id102"><span class="name western">Thilo Dörk</span></a><div hidden="hidden" id="id102"> <h3><span class="name western">Thilo Dörk</span></h3> <div class="p"> <sup>76</sup>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22D%C3%B6rk%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Thilo Dörk</span></a> </div> </div> <sup>76</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pelttari%20LM%22%5BAuthor%5D" class="usa-link" aria-describedby="id103"><span class="name western">Liisa M Pelttari</span></a><div hidden="hidden" id="id103"> <h3><span class="name western">Liisa M Pelttari</span></h3> <div class="p"> <sup>32</sup>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pelttari%20LM%22%5BAuthor%5D" class="usa-link"><span class="name western">Liisa M Pelttari</span></a> </div> </div> <sup>32</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zheng%20W%22%5BAuthor%5D" class="usa-link" aria-describedby="id104"><span class="name western">Wei Zheng</span></a><div hidden="hidden" id="id104"> <h3><span class="name western">Wei Zheng</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zheng%20W%22%5BAuthor%5D" class="usa-link"><span class="name western">Wei Zheng</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leminen%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id105"><span class="name western">Arto Leminen</span></a><div hidden="hidden" id="id105"> <h3><span class="name western">Arto Leminen</span></h3> <div class="p"> <sup>32</sup>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Leminen%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Arto Leminen</span></a> </div> </div> <sup>32</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Anton-Culver%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id106"><span class="name western">Hoda Anton-Culver</span></a><div hidden="hidden" id="id106"> <h3><span class="name western">Hoda Anton-Culver</span></h3> <div class="p"> <sup>79</sup>Department of Epidemiology, University of California Irvine, Irvine, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Anton-Culver%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hoda Anton-Culver</span></a> </div> </div> <sup>79</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bunker%20CH%22%5BAuthor%5D" class="usa-link" aria-describedby="id107"><span class="name western">Clareann H Bunker</span></a><div hidden="hidden" id="id107"> <h3><span class="name western">Clareann H Bunker</span></h3> <div class="p"> <sup>80</sup>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bunker%20CH%22%5BAuthor%5D" class="usa-link"><span class="name western">Clareann H Bunker</span></a> </div> </div> <sup>80</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kristensen%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id108"><span class="name western">Vessela Kristensen</span></a><div hidden="hidden" id="id108"> <h3><span class="name western">Vessela Kristensen</span></h3> <div class="p"> <sup>81</sup>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</div> <div class="p"> <sup>82</sup>Faculty of Medicine (Faculty Division Ahus), UiO, Norway</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kristensen%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Vessela Kristensen</span></a> </div> </div> <sup>81,</sup><sup>82</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ness%20RB%22%5BAuthor%5D" class="usa-link" aria-describedby="id109"><span class="name western">Roberta B Ness</span></a><div hidden="hidden" id="id109"> <h3><span class="name western">Roberta B Ness</span></h3> <div class="p"> <sup>83</sup>The University of Texas School of Public Health, Houston, TX, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ness%20RB%22%5BAuthor%5D" class="usa-link"><span class="name western">Roberta B Ness</span></a> </div> </div> <sup>83</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Muir%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id110"><span class="name western">Kenneth Muir</span></a><div hidden="hidden" id="id110"> <h3><span class="name western">Kenneth Muir</span></h3> <div class="p"> <sup>84</sup>Warwick Medical School, Warwick University, Coventry, UK</div> <div class="p"> <sup>85</sup>Institute of Population Health, University of Manchester, Manchester, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Muir%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kenneth Muir</span></a> </div> </div> <sup>84,</sup><sup>85</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Edwards%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id111"><span class="name western">Robert Edwards</span></a><div hidden="hidden" id="id111"> <h3><span class="name western">Robert Edwards</span></h3> <div class="p"> <sup>86</sup>Maggee Women's Hospital, Pittsburg, PA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Edwards%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Robert Edwards</span></a> </div> </div> <sup>86</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Meindl%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id112"><span class="name western">Alfons Meindl</span></a><div hidden="hidden" id="id112"> <h3><span class="name western">Alfons Meindl</span></h3> <div class="p"> <sup>87</sup>Department of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Meindl%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Alfons Meindl</span></a> </div> </div> <sup>87</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Heitz%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id113"><span class="name western">Florian Heitz</span></a><div hidden="hidden" id="id113"> <h3><span class="name western">Florian Heitz</span></h3> <div class="p"> <sup>88</sup>Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany</div> <div class="p"> <sup>89</sup>Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Heitz%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">Florian Heitz</span></a> </div> </div> <sup>88,</sup><sup>89</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Matsuo%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id114"><span class="name western">Keitaro Matsuo</span></a><div hidden="hidden" id="id114"> <h3><span class="name western">Keitaro Matsuo</span></h3> <div class="p"> <sup>90</sup>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Matsuo%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Keitaro Matsuo</span></a> </div> </div> <sup>90</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22du%20Bois%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id115"><span class="name western">Andreas du Bois</span></a><div hidden="hidden" id="id115"> <h3><span class="name western">Andreas du Bois</span></h3> <div class="p"> <sup>88</sup>Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany</div> <div class="p"> <sup>89</sup>Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22du%20Bois%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Andreas du Bois</span></a> </div> </div> <sup>88,</sup><sup>89</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wu%20AH%22%5BAuthor%5D" class="usa-link" aria-describedby="id116"><span class="name western">Anna H Wu</span></a><div hidden="hidden" id="id116"> <h3><span class="name western">Anna H Wu</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wu%20AH%22%5BAuthor%5D" class="usa-link"><span class="name western">Anna H Wu</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Harter%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id117"><span class="name western">Philipp Harter</span></a><div hidden="hidden" id="id117"> <h3><span class="name western">Philipp Harter</span></h3> <div class="p"> <sup>88</sup>Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany</div> <div class="p"> <sup>89</sup>Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Harter%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Philipp Harter</span></a> </div> </div> <sup>88,</sup><sup>89</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teo%20SH%22%5BAuthor%5D" class="usa-link" aria-describedby="id118"><span class="name western">Soo-Hwang Teo</span></a><div hidden="hidden" id="id118"> <h3><span class="name western">Soo-Hwang Teo</span></h3> <div class="p"> <sup>91</sup>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</div> <div class="p"> <sup>92</sup>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teo%20SH%22%5BAuthor%5D" class="usa-link"><span class="name western">Soo-Hwang Teo</span></a> </div> </div> <sup>91,</sup><sup>92</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schwaab%20I%22%5BAuthor%5D" class="usa-link" aria-describedby="id119"><span class="name western">Ira Schwaab</span></a><div hidden="hidden" id="id119"> <h3><span class="name western">Ira Schwaab</span></h3> <div class="p"> <sup>93</sup>Institut für Humangenetik Wiesbaden, Wiesbaden, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schwaab%20I%22%5BAuthor%5D" class="usa-link"><span class="name western">Ira Schwaab</span></a> </div> </div> <sup>93</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shu%20XO%22%5BAuthor%5D" class="usa-link" aria-describedby="id120"><span class="name western">Xiao-Ou Shu</span></a><div hidden="hidden" id="id120"> <h3><span class="name western">Xiao-Ou Shu</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shu%20XO%22%5BAuthor%5D" class="usa-link"><span class="name western">Xiao-Ou Shu</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Blot%20W%22%5BAuthor%5D" class="usa-link" aria-describedby="id121"><span class="name western">William Blot</span></a><div hidden="hidden" id="id121"> <h3><span class="name western">William Blot</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p"> <sup>94</sup>International Epidemiology Institute, Rockville, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Blot%20W%22%5BAuthor%5D" class="usa-link"><span class="name western">William Blot</span></a> </div> </div> <sup>78,</sup><sup>94</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hosono%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id122"><span class="name western">Satoyo Hosono</span></a><div hidden="hidden" id="id122"> <h3><span class="name western">Satoyo Hosono</span></h3> <div class="p"> <sup>90</sup>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hosono%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Satoyo Hosono</span></a> </div> </div> <sup>90</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kang%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id123"><span class="name western">Daehee Kang</span></a><div hidden="hidden" id="id123"> <h3><span class="name western">Daehee Kang</span></h3> <div class="p"> <sup>95</sup>Seoul National University College of Medicine, Seoul, Korea</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kang%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Daehee Kang</span></a> </div> </div> <sup>95</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nakanishi%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id124"><span class="name western">Toru Nakanishi</span></a><div hidden="hidden" id="id124"> <h3><span class="name western">Toru Nakanishi</span></h3> <div class="p"> <sup>96</sup>Department of Gynecologic Oncology, Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nakanishi%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Toru Nakanishi</span></a> </div> </div> <sup>96</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hartman%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id125"><span class="name western">Mikael Hartman</span></a><div hidden="hidden" id="id125"> <h3><span class="name western">Mikael Hartman</span></h3> <div class="p"> <sup>24</sup>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</div> <div class="p"> <sup>97</sup>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore</div> <div class="p"> <sup>98</sup>Saw Swee Hock School of Public Health, National University of Singapore</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hartman%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Mikael Hartman</span></a> </div> </div> <sup>24,</sup><sup>97,</sup><sup>98</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yatabe%20Y%22%5BAuthor%5D" class="usa-link" aria-describedby="id126"><span class="name western">Yasushi Yatabe</span></a><div hidden="hidden" id="id126"> <h3><span class="name western">Yasushi Yatabe</span></h3> <div class="p"> <sup>99</sup>Department of Pathology and Molecular Diagnostic, Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yatabe%20Y%22%5BAuthor%5D" class="usa-link"><span class="name western">Yasushi Yatabe</span></a> </div> </div> <sup>99</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hamann%20U%22%5BAuthor%5D" class="usa-link" aria-describedby="id127"><span class="name western">Ute Hamann</span></a><div hidden="hidden" id="id127"> <h3><span class="name western">Ute Hamann</span></h3> <div class="p"> <sup>100</sup>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hamann%20U%22%5BAuthor%5D" class="usa-link"><span class="name western">Ute Hamann</span></a> </div> </div> <sup>100</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Karlan%20BY%22%5BAuthor%5D" class="usa-link" aria-describedby="id128"><span class="name western">Beth Y Karlan</span></a><div hidden="hidden" id="id128"> <h3><span class="name western">Beth Y Karlan</span></h3> <div class="p"> <sup>101</sup>Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Karlan%20BY%22%5BAuthor%5D" class="usa-link"><span class="name western">Beth Y Karlan</span></a> </div> </div> <sup>101</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sangrajrang%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id129"><span class="name western">Suleeporn Sangrajrang</span></a><div hidden="hidden" id="id129"> <h3><span class="name western">Suleeporn Sangrajrang</span></h3> <div class="p"> <sup>102</sup>National Cancer Institute, Bangkok, Thailand</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sangrajrang%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Suleeporn Sangrajrang</span></a> </div> </div> <sup>102</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kjaer%20SK%22%5BAuthor%5D" class="usa-link" aria-describedby="id130"><span class="name western">Susanne Krüger Kjaer</span></a><div hidden="hidden" id="id130"> <h3><span class="name western">Susanne Krüger Kjaer</span></h3> <div class="p"> <sup>103</sup>Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</div> <div class="p"> <sup>104</sup>The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kjaer%20SK%22%5BAuthor%5D" class="usa-link"><span class="name western">Susanne Krüger Kjaer</span></a> </div> </div> <sup>103,</sup><sup>104</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gaborieau%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id131"><span class="name western">Valerie Gaborieau</span></a><div hidden="hidden" id="id131"> <h3><span class="name western">Valerie Gaborieau</span></h3> <div class="p"> <sup>105</sup>International Agency for Research on Cancer, Lyon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gaborieau%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Valerie Gaborieau</span></a> </div> </div> <sup>105</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jensen%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id132"><span class="name western">Allan Jensen</span></a><div hidden="hidden" id="id132"> <h3><span class="name western">Allan Jensen</span></h3> <div class="p"> <sup>103</sup>Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jensen%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Allan Jensen</span></a> </div> </div> <sup>103</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Eccles%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id133"><span class="name western">Diana Eccles</span></a><div hidden="hidden" id="id133"> <h3><span class="name western">Diana Eccles</span></h3> <div class="p"> <sup>106</sup>Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Eccles%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Diana Eccles</span></a> </div> </div> <sup>106</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22H%C3%B8gdall%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id134"><span class="name western">Estrid Høgdall</span></a><div hidden="hidden" id="id134"> <h3><span class="name western">Estrid Høgdall</span></h3> <div class="p"> <sup>103</sup>Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</div> <div class="p"> <sup>107</sup>Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22H%C3%B8gdall%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Estrid Høgdall</span></a> </div> </div> <sup>103,</sup><sup>107</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shen%20CY%22%5BAuthor%5D" class="usa-link" aria-describedby="id135"><span class="name western">Chen-Yang Shen</span></a><div hidden="hidden" id="id135"> <h3><span class="name western">Chen-Yang Shen</span></h3> <div class="p"> <sup>108</sup>Colleague of Public Health, China Medical University, Taichong, Taiwan</div> <div class="p"> <sup>109</sup>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shen%20CY%22%5BAuthor%5D" class="usa-link"><span class="name western">Chen-Yang Shen</span></a> </div> </div> <sup>108,</sup><sup>109</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brown%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id136"><span class="name western">Judith Brown</span></a><div hidden="hidden" id="id136"> <h3><span class="name western">Judith Brown</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brown%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Judith Brown</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Woo%20YL%22%5BAuthor%5D" class="usa-link" aria-describedby="id137"><span class="name western">Yin Ling Woo</span></a><div hidden="hidden" id="id137"> <h3><span class="name western">Yin Ling Woo</span></h3> <div class="p"> <sup>110</sup>Department of Obstetrics and Gynaecology, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Woo%20YL%22%5BAuthor%5D" class="usa-link"><span class="name western">Yin Ling Woo</span></a> </div> </div> <sup>110</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shah%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id138"><span class="name western">Mitul Shah</span></a><div hidden="hidden" id="id138"> <h3><span class="name western">Mitul Shah</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shah%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Mitul Shah</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Azmi%20MAN%22%5BAuthor%5D" class="usa-link" aria-describedby="id139"><span class="name western">Mat Adenan Noor Azmi</span></a><div hidden="hidden" id="id139"> <h3><span class="name western">Mat Adenan Noor Azmi</span></h3> <div class="p"> <sup>110</sup>Department of Obstetrics and Gynaecology, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Azmi%20MAN%22%5BAuthor%5D" class="usa-link"><span class="name western">Mat Adenan Noor Azmi</span></a> </div> </div> <sup>110</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Luben%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id140"><span class="name western">Robert Luben</span></a><div hidden="hidden" id="id140"> <h3><span class="name western">Robert Luben</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Luben%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Robert Luben</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Omar%20SZ%22%5BAuthor%5D" class="usa-link" aria-describedby="id141"><span class="name western">Siti Zawiah Omar</span></a><div hidden="hidden" id="id141"> <h3><span class="name western">Siti Zawiah Omar</span></h3> <div class="p"> <sup>110</sup>Department of Obstetrics and Gynaecology, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Omar%20SZ%22%5BAuthor%5D" class="usa-link"><span class="name western">Siti Zawiah Omar</span></a> </div> </div> <sup>110</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Czene%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id142"><span class="name western">Kamila Czene</span></a><div hidden="hidden" id="id142"> <h3><span class="name western">Kamila Czene</span></h3> <div class="p"> <sup>24</sup>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Czene%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kamila Czene</span></a> </div> </div> <sup>24</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vierkant%20RA%22%5BAuthor%5D" class="usa-link" aria-describedby="id143"><span class="name western">Robert A Vierkant</span></a><div hidden="hidden" id="id143"> <h3><span class="name western">Robert A Vierkant</span></h3> <div class="p"> <sup>23</sup>Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vierkant%20RA%22%5BAuthor%5D" class="usa-link"><span class="name western">Robert A Vierkant</span></a> </div> </div> <sup>23</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nordestgaard%20BG%22%5BAuthor%5D" class="usa-link" aria-describedby="id144"><span class="name western">Børge G Nordestgaard</span></a><div hidden="hidden" id="id144"> <h3><span class="name western">Børge G Nordestgaard</span></h3> <div class="p"> <sup>1</sup>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p"> <sup>2</sup>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nordestgaard%20BG%22%5BAuthor%5D" class="usa-link"><span class="name western">Børge G Nordestgaard</span></a> </div> </div> <sup>1,</sup><sup>2</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Flyger%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id145"><span class="name western">Henrik Flyger</span></a><div hidden="hidden" id="id145"> <h3><span class="name western">Henrik Flyger</span></h3> <div class="p"> <sup>111</sup>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Flyger%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Henrik Flyger</span></a> </div> </div> <sup>111</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vachon%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id146"><span class="name western">Celine Vachon</span></a><div hidden="hidden" id="id146"> <h3><span class="name western">Celine Vachon</span></h3> <div class="p"> <sup>112</sup>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vachon%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Celine Vachon</span></a> </div> </div> <sup>112</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olson%20JE%22%5BAuthor%5D" class="usa-link" aria-describedby="id147"><span class="name western">Janet E Olson</span></a><div hidden="hidden" id="id147"> <h3><span class="name western">Janet E Olson</span></h3> <div class="p"> <sup>112</sup>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olson%20JE%22%5BAuthor%5D" class="usa-link"><span class="name western">Janet E Olson</span></a> </div> </div> <sup>112</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang%20X%22%5BAuthor%5D" class="usa-link" aria-describedby="id148"><span class="name western">Xianshu Wang</span></a><div hidden="hidden" id="id148"> <h3><span class="name western">Xianshu Wang</span></h3> <div class="p"> <sup>39</sup>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang%20X%22%5BAuthor%5D" class="usa-link"><span class="name western">Xianshu Wang</span></a> </div> </div> <sup>39</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Levine%20DA%22%5BAuthor%5D" class="usa-link" aria-describedby="id149"><span class="name western">Douglas A Levine</span></a><div hidden="hidden" id="id149"> <h3><span class="name western">Douglas A Levine</span></h3> <div class="p"> <sup>113</sup>Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Levine%20DA%22%5BAuthor%5D" class="usa-link"><span class="name western">Douglas A Levine</span></a> </div> </div> <sup>113</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rudolph%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id150"><span class="name western">Anja Rudolph</span></a><div hidden="hidden" id="id150"> <h3><span class="name western">Anja Rudolph</span></h3> <div class="p"> <sup>25</sup>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rudolph%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Anja Rudolph</span></a> </div> </div> <sup>25</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Weber%20RP%22%5BAuthor%5D" class="usa-link" aria-describedby="id151"><span class="name western">Rachel Palmieri Weber</span></a><div hidden="hidden" id="id151"> <h3><span class="name western">Rachel Palmieri Weber</span></h3> <div class="p"> <sup>114</sup>Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Weber%20RP%22%5BAuthor%5D" class="usa-link"><span class="name western">Rachel Palmieri Weber</span></a> </div> </div> <sup>114</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Flesch-Janys%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id152"><span class="name western">Dieter Flesch-Janys</span></a><div hidden="hidden" id="id152"> <h3><span class="name western">Dieter Flesch-Janys</span></h3> <div class="p"> <sup>115</sup>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</div> <div class="p"> <sup>116</sup>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Flesch-Janys%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Dieter Flesch-Janys</span></a> </div> </div> <sup>115,</sup><sup>116</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iversen%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id153"><span class="name western">Edwin Iversen</span></a><div hidden="hidden" id="id153"> <h3><span class="name western">Edwin Iversen</span></h3> <div class="p"> <sup>117</sup>Department of Statistical Science, Duke University, Durham, NC, USA</div> <div class="p"> <sup>118</sup>Cancer Prevention, Detection and Control Research Program, Duke Cancer Institute, Durham, NC, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iversen%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Edwin Iversen</span></a> </div> </div> <sup>117,</sup><sup>118</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nickels%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id154"><span class="name western">Stefan Nickels</span></a><div hidden="hidden" id="id154"> <h3><span class="name western">Stefan Nickels</span></h3> <div class="p"> <sup>25</sup>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nickels%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Stefan Nickels</span></a> </div> </div> <sup>25</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schildkraut%20JM%22%5BAuthor%5D" class="usa-link" aria-describedby="id155"><span class="name western">Joellen M Schildkraut</span></a><div hidden="hidden" id="id155"> <h3><span class="name western">Joellen M Schildkraut</span></h3> <div class="p"> <sup>114</sup>Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</div> <div class="p"> <sup>118</sup>Cancer Prevention, Detection and Control Research Program, Duke Cancer Institute, Durham, NC, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schildkraut%20JM%22%5BAuthor%5D" class="usa-link"><span class="name western">Joellen M Schildkraut</span></a> </div> </div> <sup>114,</sup><sup>118</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Silva%20IDS%22%5BAuthor%5D" class="usa-link" aria-describedby="id156"><span class="name western">Isabel Dos Santos Silva</span></a><div hidden="hidden" id="id156"> <h3><span class="name western">Isabel Dos Santos Silva</span></h3> <div class="p"> <sup>27</sup>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Silva%20IDS%22%5BAuthor%5D" class="usa-link"><span class="name western">Isabel Dos Santos Silva</span></a> </div> </div> <sup>27</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cramer%20DW%22%5BAuthor%5D" class="usa-link" aria-describedby="id157"><span class="name western">Daniel W Cramer</span></a><div hidden="hidden" id="id157"> <h3><span class="name western">Daniel W Cramer</span></h3> <div class="p"> <sup>119</sup>Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</div> <div class="p"> <sup>120</sup>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cramer%20DW%22%5BAuthor%5D" class="usa-link"><span class="name western">Daniel W Cramer</span></a> </div> </div> <sup>119,</sup><sup>120</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gibson%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id158"><span class="name western">Lorna Gibson</span></a><div hidden="hidden" id="id158"> <h3><span class="name western">Lorna Gibson</span></h3> <div class="p"> <sup>27</sup>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gibson%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Lorna Gibson</span></a> </div> </div> <sup>27</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Terry%20KL%22%5BAuthor%5D" class="usa-link" aria-describedby="id159"><span class="name western">Kathryn L Terry</span></a><div hidden="hidden" id="id159"> <h3><span class="name western">Kathryn L Terry</span></h3> <div class="p"> <sup>119</sup>Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</div> <div class="p"> <sup>120</sup>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Terry%20KL%22%5BAuthor%5D" class="usa-link"><span class="name western">Kathryn L Terry</span></a> </div> </div> <sup>119,</sup><sup>120</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fletcher%20O%22%5BAuthor%5D" class="usa-link" aria-describedby="id160"><span class="name western">Olivia Fletcher</span></a><div hidden="hidden" id="id160"> <h3><span class="name western">Olivia Fletcher</span></h3> <div class="p"> <sup>65</sup>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fletcher%20O%22%5BAuthor%5D" class="usa-link"><span class="name western">Olivia Fletcher</span></a> </div> </div> <sup>65</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vitonis%20AF%22%5BAuthor%5D" class="usa-link" aria-describedby="id161"><span class="name western">Allison F Vitonis</span></a><div hidden="hidden" id="id161"> <h3><span class="name western">Allison F Vitonis</span></h3> <div class="p"> <sup>119</sup>Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Vitonis%20AF%22%5BAuthor%5D" class="usa-link"><span class="name western">Allison F Vitonis</span></a> </div> </div> <sup>119</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20der%20Schoot%20CE%22%5BAuthor%5D" class="usa-link" aria-describedby="id162"><span class="name western">C Ellen van der Schoot</span></a><div hidden="hidden" id="id162"> <h3><span class="name western">C Ellen van der Schoot</span></h3> <div class="p"> <sup>121</sup>Sanquin Research, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20der%20Schoot%20CE%22%5BAuthor%5D" class="usa-link"><span class="name western">C Ellen van der Schoot</span></a> </div> </div> <sup>121</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Poole%20EM%22%5BAuthor%5D" class="usa-link" aria-describedby="id163"><span class="name western">Elizabeth M Poole</span></a><div hidden="hidden" id="id163"> <h3><span class="name western">Elizabeth M Poole</span></h3> <div class="p"> <sup>120</sup>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</div> <div class="p"> <sup>122</sup>Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Poole%20EM%22%5BAuthor%5D" class="usa-link"><span class="name western">Elizabeth M Poole</span></a> </div> </div> <sup>120,</sup><sup>122</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hogervorst%20FBL%22%5BAuthor%5D" class="usa-link" aria-describedby="id164"><span class="name western">Frans B L Hogervorst</span></a><div hidden="hidden" id="id164"> <h3><span class="name western">Frans B L Hogervorst</span></h3> <div class="p"> <sup>123</sup>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hogervorst%20FBL%22%5BAuthor%5D" class="usa-link"><span class="name western">Frans B L Hogervorst</span></a> </div> </div> <sup>123</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tworoger%20SS%22%5BAuthor%5D" class="usa-link" aria-describedby="id165"><span class="name western">Shelley S Tworoger</span></a><div hidden="hidden" id="id165"> <h3><span class="name western">Shelley S Tworoger</span></h3> <div class="p"> <sup>120</sup>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</div> <div class="p"> <sup>122</sup>Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tworoger%20SS%22%5BAuthor%5D" class="usa-link"><span class="name western">Shelley S Tworoger</span></a> </div> </div> <sup>120,</sup><sup>122</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Liu%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id166"><span class="name western">Jianjun Liu</span></a><div hidden="hidden" id="id166"> <h3><span class="name western">Jianjun Liu</span></h3> <div class="p"> <sup>124</sup>Human Genetics Division, Genome Institute of Singapore, Singapore</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Liu%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jianjun Liu</span></a> </div> </div> <sup>124</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bandera%20EV%22%5BAuthor%5D" class="usa-link" aria-describedby="id167"><span class="name western">Elisa V Bandera</span></a><div hidden="hidden" id="id167"> <h3><span class="name western">Elisa V Bandera</span></h3> <div class="p"> <sup>125</sup>The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bandera%20EV%22%5BAuthor%5D" class="usa-link"><span class="name western">Elisa V Bandera</span></a> </div> </div> <sup>125</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Li%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id168"><span class="name western">Jingmei Li</span></a><div hidden="hidden" id="id168"> <h3><span class="name western">Jingmei Li</span></h3> <div class="p"> <sup>124</sup>Human Genetics Division, Genome Institute of Singapore, Singapore</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Li%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jingmei Li</span></a> </div> </div> <sup>124</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olson%20SH%22%5BAuthor%5D" class="usa-link" aria-describedby="id169"><span class="name western">Sara H Olson</span></a><div hidden="hidden" id="id169"> <h3><span class="name western">Sara H Olson</span></h3> <div class="p"> <sup>126</sup>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olson%20SH%22%5BAuthor%5D" class="usa-link"><span class="name western">Sara H Olson</span></a> </div> </div> <sup>126</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Humphreys%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id170"><span class="name western">Keith Humphreys</span></a><div hidden="hidden" id="id170"> <h3><span class="name western">Keith Humphreys</span></h3> <div class="p"> <sup>24</sup>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Humphreys%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Keith Humphreys</span></a> </div> </div> <sup>24</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orlow%20I%22%5BAuthor%5D" class="usa-link" aria-describedby="id171"><span class="name western">Irene Orlow</span></a><div hidden="hidden" id="id171"> <h3><span class="name western">Irene Orlow</span></h3> <div class="p"> <sup>126</sup>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orlow%20I%22%5BAuthor%5D" class="usa-link"><span class="name western">Irene Orlow</span></a> </div> </div> <sup>126</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Blomqvist%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id172"><span class="name western">Carl Blomqvist</span></a><div hidden="hidden" id="id172"> <h3><span class="name western">Carl Blomqvist</span></h3> <div class="p"> <sup>127</sup>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Blomqvist%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Carl Blomqvist</span></a> </div> </div> <sup>127</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rodriguez-Rodriguez%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id173"><span class="name western">Lorna Rodriguez-Rodriguez</span></a><div hidden="hidden" id="id173"> <h3><span class="name western">Lorna Rodriguez-Rodriguez</span></h3> <div class="p"> <sup>125</sup>The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rodriguez-Rodriguez%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Lorna Rodriguez-Rodriguez</span></a> </div> </div> <sup>125</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aittom%C3%A4ki%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id174"><span class="name western">Kristiina Aittomäki</span></a><div hidden="hidden" id="id174"> <h3><span class="name western">Kristiina Aittomäki</span></h3> <div class="p"> <sup>128</sup>Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aittom%C3%A4ki%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kristiina Aittomäki</span></a> </div> </div> <sup>128</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Salvesen%20HB%22%5BAuthor%5D" class="usa-link" aria-describedby="id175"><span class="name western">Helga B Salvesen</span></a><div hidden="hidden" id="id175"> <h3><span class="name western">Helga B Salvesen</span></h3> <div class="p"> <sup>129</sup>Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</div> <div class="p"> <sup>130</sup>Department of Clinical Medicine, University of Bergen, Bergen, Norway</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Salvesen%20HB%22%5BAuthor%5D" class="usa-link"><span class="name western">Helga B Salvesen</span></a> </div> </div> <sup>129,</sup><sup>130</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Muranen%20TA%22%5BAuthor%5D" class="usa-link" aria-describedby="id176"><span class="name western">Taru A Muranen</span></a><div hidden="hidden" id="id176"> <h3><span class="name western">Taru A Muranen</span></h3> <div class="p"> <sup>32</sup>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Muranen%20TA%22%5BAuthor%5D" class="usa-link"><span class="name western">Taru A Muranen</span></a> </div> </div> <sup>32</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wik%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id177"><span class="name western">Elisabeth Wik</span></a><div hidden="hidden" id="id177"> <h3><span class="name western">Elisabeth Wik</span></h3> <div class="p"> <sup>129</sup>Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</div> <div class="p"> <sup>130</sup>Department of Clinical Medicine, University of Bergen, Bergen, Norway</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wik%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Elisabeth Wik</span></a> </div> </div> <sup>129,</sup><sup>130</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brouwers%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id178"><span class="name western">Barbara Brouwers</span></a><div hidden="hidden" id="id178"> <h3><span class="name western">Barbara Brouwers</span></h3> <div class="p"> <sup>131</sup>Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium</div> <div class="p"> <sup>132</sup>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brouwers%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Barbara Brouwers</span></a> </div> </div> <sup>131,</sup><sup>132</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Krakstad%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id179"><span class="name western">Camilla Krakstad</span></a><div hidden="hidden" id="id179"> <h3><span class="name western">Camilla Krakstad</span></h3> <div class="p"> <sup>129</sup>Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</div> <div class="p"> <sup>130</sup>Department of Clinical Medicine, University of Bergen, Bergen, Norway</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Krakstad%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Camilla Krakstad</span></a> </div> </div> <sup>129,</sup><sup>130</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wauters%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id180"><span class="name western">Els Wauters</span></a><div hidden="hidden" id="id180"> <h3><span class="name western">Els Wauters</span></h3> <div class="p"> <sup>34</sup>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium</div> <div class="p"> <sup>35</sup>Vesalius Research Center (VRC), VIB, Leuven, Belgium</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wauters%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Els Wauters</span></a> </div> </div> <sup>34,</sup><sup>35</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Halle%20MK%22%5BAuthor%5D" class="usa-link" aria-describedby="id181"><span class="name western">Mari K Halle</span></a><div hidden="hidden" id="id181"> <h3><span class="name western">Mari K Halle</span></h3> <div class="p"> <sup>129</sup>Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</div> <div class="p"> <sup>130</sup>Department of Clinical Medicine, University of Bergen, Bergen, Norway</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Halle%20MK%22%5BAuthor%5D" class="usa-link"><span class="name western">Mari K Halle</span></a> </div> </div> <sup>129,</sup><sup>130</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wildiers%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id182"><span class="name western">Hans Wildiers</span></a><div hidden="hidden" id="id182"> <h3><span class="name western">Hans Wildiers</span></h3> <div class="p"> <sup>133</sup>Department of General Medical Oncology, University Hospitals Leuven, Belgium</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wildiers%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hans Wildiers</span></a> </div> </div> <sup>133</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kiemeney%20LA%22%5BAuthor%5D" class="usa-link" aria-describedby="id183"><span class="name western">Lambertus A Kiemeney</span></a><div hidden="hidden" id="id183"> <h3><span class="name western">Lambertus A Kiemeney</span></h3> <div class="p"> <sup>134</sup>Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands</div> <div class="p"> <sup>135</sup>Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div class="p"> <sup>136</sup>Department of Urology, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kiemeney%20LA%22%5BAuthor%5D" class="usa-link"><span class="name western">Lambertus A Kiemeney</span></a> </div> </div> <sup>134,</sup><sup>135,</sup><sup>136</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mulot%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id184"><span class="name western">Claire Mulot</span></a><div hidden="hidden" id="id184"> <h3><span class="name western">Claire Mulot</span></h3> <div class="p"> <sup>137</sup>Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mulot%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Claire Mulot</span></a> </div> </div> <sup>137</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aben%20KK%22%5BAuthor%5D" class="usa-link" aria-describedby="id185"><span class="name western">Katja K Aben</span></a><div hidden="hidden" id="id185"> <h3><span class="name western">Katja K Aben</span></h3> <div class="p"> <sup>134</sup>Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands</div> <div class="p"> <sup>135</sup>Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aben%20KK%22%5BAuthor%5D" class="usa-link"><span class="name western">Katja K Aben</span></a> </div> </div> <sup>134,</sup><sup>135</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laurent-Puig%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id186"><span class="name western">Pierre Laurent-Puig</span></a><div hidden="hidden" id="id186"> <h3><span class="name western">Pierre Laurent-Puig</span></h3> <div class="p"> <sup>137</sup>Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laurent-Puig%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Pierre Laurent-Puig</span></a> </div> </div> <sup>137</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Altena%20AM%22%5BAuthor%5D" class="usa-link" aria-describedby="id187"><span class="name western">Anne M van Altena</span></a><div hidden="hidden" id="id187"> <h3><span class="name western">Anne M van Altena</span></h3> <div class="p"> <sup>138</sup>Department of Gynecology, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Altena%20AM%22%5BAuthor%5D" class="usa-link"><span class="name western">Anne M van Altena</span></a> </div> </div> <sup>138</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Truong%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id188"><span class="name western">Thérèse Truong</span></a><div hidden="hidden" id="id188"> <h3><span class="name western">Thérèse Truong</span></h3> <div class="p"> <sup>36</sup>INSERM U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France</div> <div class="p"> <sup>37</sup>University Paris-Sud, UMRS 1018, Villejuif, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Truong%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Thérèse Truong</span></a> </div> </div> <sup>36,</sup><sup>37</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Massuger%20LFAG%22%5BAuthor%5D" class="usa-link" aria-describedby="id189"><span class="name western">Leon F A G Massuger</span></a><div hidden="hidden" id="id189"> <h3><span class="name western">Leon F A G Massuger</span></h3> <div class="p"> <sup>138</sup>Department of Gynecology, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Massuger%20LFAG%22%5BAuthor%5D" class="usa-link"><span class="name western">Leon F A G Massuger</span></a> </div> </div> <sup>138</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Benitez%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id190"><span class="name western">Javier Benitez</span></a><div hidden="hidden" id="id190"> <h3><span class="name western">Javier Benitez</span></h3> <div class="p"> <sup>19</sup>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div class="p"> <sup>139</sup>Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div class="p"> <sup>140</sup>Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Benitez%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Javier Benitez</span></a> </div> </div> <sup>19,</sup><sup>139,</sup><sup>140</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pejovic%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id191"><span class="name western">Tanja Pejovic</span></a><div hidden="hidden" id="id191"> <h3><span class="name western">Tanja Pejovic</span></h3> <div class="p"> <sup>141</sup>Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</div> <div class="p"> <sup>142</sup>Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pejovic%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Tanja Pejovic</span></a> </div> </div> <sup>141,</sup><sup>142</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Perez%20JIA%22%5BAuthor%5D" class="usa-link" aria-describedby="id192"><span class="name western">Jose Ignacio Arias Perez</span></a><div hidden="hidden" id="id192"> <h3><span class="name western">Jose Ignacio Arias Perez</span></h3> <div class="p"> <sup>143</sup>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Perez%20JIA%22%5BAuthor%5D" class="usa-link"><span class="name western">Jose Ignacio Arias Perez</span></a> </div> </div> <sup>143</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hoatlin%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id193"><span class="name western">Maureen Hoatlin</span></a><div hidden="hidden" id="id193"> <h3><span class="name western">Maureen Hoatlin</span></h3> <div class="p"> <sup>144</sup>Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hoatlin%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Maureen Hoatlin</span></a> </div> </div> <sup>144</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zamora%20MP%22%5BAuthor%5D" class="usa-link" aria-describedby="id194"><span class="name western">M Pilar Zamora</span></a><div hidden="hidden" id="id194"> <h3><span class="name western">M Pilar Zamora</span></h3> <div class="p"> <sup>145</sup>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zamora%20MP%22%5BAuthor%5D" class="usa-link"><span class="name western">M Pilar Zamora</span></a> </div> </div> <sup>145</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cook%20LS%22%5BAuthor%5D" class="usa-link" aria-describedby="id195"><span class="name western">Linda S Cook</span></a><div hidden="hidden" id="id195"> <h3><span class="name western">Linda S Cook</span></h3> <div class="p"> <sup>146</sup>Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, NM, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cook%20LS%22%5BAuthor%5D" class="usa-link"><span class="name western">Linda S Cook</span></a> </div> </div> <sup>146</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Balasubramanian%20SP%22%5BAuthor%5D" class="usa-link" aria-describedby="id196"><span class="name western">Sabapathy P Balasubramanian</span></a><div hidden="hidden" id="id196"> <h3><span class="name western">Sabapathy P Balasubramanian</span></h3> <div class="p"> <sup>40</sup>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Balasubramanian%20SP%22%5BAuthor%5D" class="usa-link"><span class="name western">Sabapathy P Balasubramanian</span></a> </div> </div> <sup>40</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kelemen%20LE%22%5BAuthor%5D" class="usa-link" aria-describedby="id197"><span class="name western">Linda E Kelemen</span></a><div hidden="hidden" id="id197"> <h3><span class="name western">Linda E Kelemen</span></h3> <div class="p"> <sup>147</sup>Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, Alberta, Canada</div> <div class="p"> <sup>148</sup>Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada</div> <div class="p"> <sup>149</sup>Department of Oncology, University of Calgary, Calgary, Alberta, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kelemen%20LE%22%5BAuthor%5D" class="usa-link"><span class="name western">Linda E Kelemen</span></a> </div> </div> <sup>147,</sup><sup>148,</sup><sup>149</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schneeweiss%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id198"><span class="name western">Andreas Schneeweiss</span></a><div hidden="hidden" id="id198"> <h3><span class="name western">Andreas Schneeweiss</span></h3> <div class="p"> <sup>41</sup>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</div> <div class="p"> <sup>43</sup>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schneeweiss%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Andreas Schneeweiss</span></a> </div> </div> <sup>41,</sup><sup>43</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Le%20ND%22%5BAuthor%5D" class="usa-link" aria-describedby="id199"><span class="name western">Nhu D Le</span></a><div hidden="hidden" id="id199"> <h3><span class="name western">Nhu D Le</span></h3> <div class="p"> <sup>150</sup>Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Le%20ND%22%5BAuthor%5D" class="usa-link"><span class="name western">Nhu D Le</span></a> </div> </div> <sup>150</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sohn%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id200"><span class="name western">Christof Sohn</span></a><div hidden="hidden" id="id200"> <h3><span class="name western">Christof Sohn</span></h3> <div class="p"> <sup>41</sup>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sohn%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Christof Sohn</span></a> </div> </div> <sup>41</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brooks-Wilson%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id201"><span class="name western">Angela Brooks-Wilson</span></a><div hidden="hidden" id="id201"> <h3><span class="name western">Angela Brooks-Wilson</span></h3> <div class="p"> <sup>151</sup>Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada</div> <div class="p"> <sup>152</sup>Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brooks-Wilson%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Angela Brooks-Wilson</span></a> </div> </div> <sup>151,</sup><sup>152</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tomlinson%20I%22%5BAuthor%5D" class="usa-link" aria-describedby="id202"><span class="name western">Ian Tomlinson</span></a><div hidden="hidden" id="id202"> <h3><span class="name western">Ian Tomlinson</span></h3> <div class="p"> <sup>153</sup>Welcome Trust Centre for Human Genetics, University of Oxford, UK</div> <div class="p"> <sup>154</sup>Oxford Biomedical Research Centre, University of Oxford, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tomlinson%20I%22%5BAuthor%5D" class="usa-link"><span class="name western">Ian Tomlinson</span></a> </div> </div> <sup>153,</sup><sup>154</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kerin%20MJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id203"><span class="name western">Michael J Kerin</span></a><div hidden="hidden" id="id203"> <h3><span class="name western">Michael J Kerin</span></h3> <div class="p"> <sup>155</sup>School of medicine, National University of Ireland Galway, Ireland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kerin%20MJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Michael J Kerin</span></a> </div> </div> <sup>155</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Miller%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id204"><span class="name western">Nicola Miller</span></a><div hidden="hidden" id="id204"> <h3><span class="name western">Nicola Miller</span></h3> <div class="p"> <sup>155</sup>School of medicine, National University of Ireland Galway, Ireland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Miller%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nicola Miller</span></a> </div> </div> <sup>155</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cybulski%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id205"><span class="name western">Cezary Cybulski</span></a><div hidden="hidden" id="id205"> <h3><span class="name western">Cezary Cybulski</span></h3> <div class="p"> <sup>156</sup>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical Academy, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cybulski%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Cezary Cybulski</span></a> </div> </div> <sup>156</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Henderson%20BE%22%5BAuthor%5D" class="usa-link" aria-describedby="id206"><span class="name western">Brian E Henderson</span></a><div hidden="hidden" id="id206"> <h3><span class="name western">Brian E Henderson</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Henderson%20BE%22%5BAuthor%5D" class="usa-link"><span class="name western">Brian E Henderson</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Menkiszak%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id207"><span class="name western">Janusz Menkiszak</span></a><div hidden="hidden" id="id207"> <h3><span class="name western">Janusz Menkiszak</span></h3> <div class="p"> <sup>157</sup>Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Menkiszak%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Janusz Menkiszak</span></a> </div> </div> <sup>157</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schumacher%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id208"><span class="name western">Fredrick Schumacher</span></a><div hidden="hidden" id="id208"> <h3><span class="name western">Fredrick Schumacher</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schumacher%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">Fredrick Schumacher</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wentzensen%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id209"><span class="name western">Nicolas Wentzensen</span></a><div hidden="hidden" id="id209"> <h3><span class="name western">Nicolas Wentzensen</span></h3> <div class="p"> <sup>158</sup>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wentzensen%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nicolas Wentzensen</span></a> </div> </div> <sup>158</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Marchand%20LL%22%5BAuthor%5D" class="usa-link" aria-describedby="id210"><span class="name western">Loic Le Marchand</span></a><div hidden="hidden" id="id210"> <h3><span class="name western">Loic Le Marchand</span></h3> <div class="p"> <sup>159</sup>Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Marchand%20LL%22%5BAuthor%5D" class="usa-link"><span class="name western">Loic Le Marchand</span></a> </div> </div> <sup>159</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yang%20HP%22%5BAuthor%5D" class="usa-link" aria-describedby="id211"><span class="name western">Hannah P Yang</span></a><div hidden="hidden" id="id211"> <h3><span class="name western">Hannah P Yang</span></h3> <div class="p"> <sup>158</sup>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yang%20HP%22%5BAuthor%5D" class="usa-link"><span class="name western">Hannah P Yang</span></a> </div> </div> <sup>158</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mulligan%20AM%22%5BAuthor%5D" class="usa-link" aria-describedby="id212"><span class="name western">Anna Marie Mulligan</span></a><div hidden="hidden" id="id212"> <h3><span class="name western">Anna Marie Mulligan</span></h3> <div class="p"> <sup>160</sup>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</div> <div class="p"> <sup>161</sup>Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mulligan%20AM%22%5BAuthor%5D" class="usa-link"><span class="name western">Anna Marie Mulligan</span></a> </div> </div> <sup>160,</sup><sup>161</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glendon%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id213"><span class="name western">Gord Glendon</span></a><div hidden="hidden" id="id213"> <h3><span class="name western">Gord Glendon</span></h3> <div class="p"> <sup>162</sup>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glendon%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">Gord Glendon</span></a> </div> </div> <sup>162</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Engelholm%20SA%22%5BAuthor%5D" class="usa-link" aria-describedby="id214"><span class="name western">Svend Aage Engelholm</span></a><div hidden="hidden" id="id214"> <h3><span class="name western">Svend Aage Engelholm</span></h3> <div class="p"> <sup>163</sup>Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Engelholm%20SA%22%5BAuthor%5D" class="usa-link"><span class="name western">Svend Aage Engelholm</span></a> </div> </div> <sup>163</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Knight%20JA%22%5BAuthor%5D" class="usa-link" aria-describedby="id215"><span class="name western">Julia A Knight</span></a><div hidden="hidden" id="id215"> <h3><span class="name western">Julia A Knight</span></h3> <div class="p"> <sup>164</sup>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</div> <div class="p"> <sup>165</sup>Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Knight%20JA%22%5BAuthor%5D" class="usa-link"><span class="name western">Julia A Knight</span></a> </div> </div> <sup>164,</sup><sup>165</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22H%C3%B8gdall%20CK%22%5BAuthor%5D" class="usa-link" aria-describedby="id216"><span class="name western">Claus K Høgdall</span></a><div hidden="hidden" id="id216"> <h3><span class="name western">Claus K Høgdall</span></h3> <div class="p"> <sup>104</sup>The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22H%C3%B8gdall%20CK%22%5BAuthor%5D" class="usa-link"><span class="name western">Claus K Høgdall</span></a> </div> </div> <sup>104</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Apicella%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id217"><span class="name western">Carmel Apicella</span></a><div hidden="hidden" id="id217"> <h3><span class="name western">Carmel Apicella</span></h3> <div class="p"> <sup>50</sup>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Apicella%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Carmel Apicella</span></a> </div> </div> <sup>50</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gore%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id218"><span class="name western">Martin Gore</span></a><div hidden="hidden" id="id218"> <h3><span class="name western">Martin Gore</span></h3> <div class="p"> <sup>166</sup>Gynecological Oncology Unit, The Royal Marsden Hospital, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gore%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Martin Gore</span></a> </div> </div> <sup>166</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tsimiklis%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id219"><span class="name western">Helen Tsimiklis</span></a><div hidden="hidden" id="id219"> <h3><span class="name western">Helen Tsimiklis</span></h3> <div class="p"> <sup>167</sup>Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, Melbourne, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tsimiklis%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Helen Tsimiklis</span></a> </div> </div> <sup>167</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Song%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id220"><span class="name western">Honglin Song</span></a><div hidden="hidden" id="id220"> <h3><span class="name western">Honglin Song</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Song%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Honglin Song</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Southey%20MC%22%5BAuthor%5D" class="usa-link" aria-describedby="id221"><span class="name western">Melissa C Southey</span></a><div hidden="hidden" id="id221"> <h3><span class="name western">Melissa C Southey</span></h3> <div class="p"> <sup>167</sup>Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, Melbourne, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Southey%20MC%22%5BAuthor%5D" class="usa-link"><span class="name western">Melissa C Southey</span></a> </div> </div> <sup>167</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jager%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id222"><span class="name western">Agnes Jager</span></a><div hidden="hidden" id="id222"> <h3><span class="name western">Agnes Jager</span></h3> <div class="p"> <sup>168</sup>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jager%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Agnes Jager</span></a> </div> </div> <sup>168</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20den%20Ouweland%20AMW%22%5BAuthor%5D" class="usa-link" aria-describedby="id223"><span class="name western">Ans M W van den Ouweland</span></a><div hidden="hidden" id="id223"> <h3><span class="name western">Ans M W van den Ouweland</span></h3> <div class="p"> <sup>169</sup>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20den%20Ouweland%20AMW%22%5BAuthor%5D" class="usa-link"><span class="name western">Ans M W van den Ouweland</span></a> </div> </div> <sup>169</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brown%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id224"><span class="name western">Robert Brown</span></a><div hidden="hidden" id="id224"> <h3><span class="name western">Robert Brown</span></h3> <div class="p"> <sup>170</sup>Department of Surgery and Cancer, Imperial College London, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Brown%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Robert Brown</span></a> </div> </div> <sup>170</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Martens%20JWM%22%5BAuthor%5D" class="usa-link" aria-describedby="id225"><span class="name western">John W M Martens</span></a><div hidden="hidden" id="id225"> <h3><span class="name western">John W M Martens</span></h3> <div class="p"> <sup>168</sup>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Martens%20JWM%22%5BAuthor%5D" class="usa-link"><span class="name western">John W M Martens</span></a> </div> </div> <sup>168</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Flanagan%20JM%22%5BAuthor%5D" class="usa-link" aria-describedby="id226"><span class="name western">James M Flanagan</span></a><div hidden="hidden" id="id226"> <h3><span class="name western">James M Flanagan</span></h3> <div class="p"> <sup>170</sup>Department of Surgery and Cancer, Imperial College London, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Flanagan%20JM%22%5BAuthor%5D" class="usa-link"><span class="name western">James M Flanagan</span></a> </div> </div> <sup>170</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kriege%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id227"><span class="name western">Mieke Kriege</span></a><div hidden="hidden" id="id227"> <h3><span class="name western">Mieke Kriege</span></h3> <div class="p"> <sup>168</sup>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kriege%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Mieke Kriege</span></a> </div> </div> <sup>168</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paul%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id228"><span class="name western">James Paul</span></a><div hidden="hidden" id="id228"> <h3><span class="name western">James Paul</span></h3> <div class="p"> <sup>171</sup>The Beatson West of Scotland Cancer Centre, Glasgow, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paul%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">James Paul</span></a> </div> </div> <sup>171</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Margolin%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id229"><span class="name western">Sara Margolin</span></a><div hidden="hidden" id="id229"> <h3><span class="name western">Sara Margolin</span></h3> <div class="p"> <sup>172</sup>Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Margolin%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Sara Margolin</span></a> </div> </div> <sup>172</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Siddiqui%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id230"><span class="name western">Nadeem Siddiqui</span></a><div hidden="hidden" id="id230"> <h3><span class="name western">Nadeem Siddiqui</span></h3> <div class="p"> <sup>173</sup>Department of Gynecological Oncology, Glasgow Royal Infirmary, Glasgow, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Siddiqui%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nadeem Siddiqui</span></a> </div> </div> <sup>173</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Severi%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id231"><span class="name western">Gianluca Severi</span></a><div hidden="hidden" id="id231"> <h3><span class="name western">Gianluca Severi</span></h3> <div class="p"> <sup>50</sup>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia</div> <div class="p"> <sup>52</sup>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Severi%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">Gianluca Severi</span></a> </div> </div> <sup>50,</sup><sup>52</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Whittemore%20AS%22%5BAuthor%5D" class="usa-link" aria-describedby="id232"><span class="name western">Alice S Whittemore</span></a><div hidden="hidden" id="id232"> <h3><span class="name western">Alice S Whittemore</span></h3> <div class="p"> <sup>174</sup>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Whittemore%20AS%22%5BAuthor%5D" class="usa-link"><span class="name western">Alice S Whittemore</span></a> </div> </div> <sup>174</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Baglietto%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id233"><span class="name western">Laura Baglietto</span></a><div hidden="hidden" id="id233"> <h3><span class="name western">Laura Baglietto</span></h3> <div class="p"> <sup>50</sup>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia</div> <div class="p"> <sup>52</sup>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Baglietto%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Laura Baglietto</span></a> </div> </div> <sup>50,</sup><sup>52</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McGuire%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id234"><span class="name western">Valerie McGuire</span></a><div hidden="hidden" id="id234"> <h3><span class="name western">Valerie McGuire</span></h3> <div class="p"> <sup>174</sup>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McGuire%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Valerie McGuire</span></a> </div> </div> <sup>174</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stegmaier%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id235"><span class="name western">Christa Stegmaier</span></a><div hidden="hidden" id="id235"> <h3><span class="name western">Christa Stegmaier</span></h3> <div class="p"> <sup>175</sup>Saarland Cancer Registry, Saarbrücken, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stegmaier%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Christa Stegmaier</span></a> </div> </div> <sup>175</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sieh%20W%22%5BAuthor%5D" class="usa-link" aria-describedby="id236"><span class="name western">Weiva Sieh</span></a><div hidden="hidden" id="id236"> <h3><span class="name western">Weiva Sieh</span></h3> <div class="p"> <sup>174</sup>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sieh%20W%22%5BAuthor%5D" class="usa-link"><span class="name western">Weiva Sieh</span></a> </div> </div> <sup>174</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22M%C3%BCller%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id237"><span class="name western">Heiko Müller</span></a><div hidden="hidden" id="id237"> <h3><span class="name western">Heiko Müller</span></h3> <div class="p"> <sup>54</sup>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22M%C3%BCller%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Heiko Müller</span></a> </div> </div> <sup>54</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Arndt%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id238"><span class="name western">Volker Arndt</span></a><div hidden="hidden" id="id238"> <h3><span class="name western">Volker Arndt</span></h3> <div class="p"> <sup>54</sup>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Arndt%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Volker Arndt</span></a> </div> </div> <sup>54</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Labr%C3%A8che%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id239"><span class="name western">France Labrèche</span></a><div hidden="hidden" id="id239"> <h3><span class="name western">France Labrèche</span></h3> <div class="p"> <sup>176</sup>Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, Quebec, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Labr%C3%A8che%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">France Labrèche</span></a> </div> </div> <sup>176</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gao%20YT%22%5BAuthor%5D" class="usa-link" aria-describedby="id240"><span class="name western">Yu-Tang Gao</span></a><div hidden="hidden" id="id240"> <h3><span class="name western">Yu-Tang Gao</span></h3> <div class="p"> <sup>177</sup>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gao%20YT%22%5BAuthor%5D" class="usa-link"><span class="name western">Yu-Tang Gao</span></a> </div> </div> <sup>177</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goldberg%20MS%22%5BAuthor%5D" class="usa-link" aria-describedby="id241"><span class="name western">Mark S Goldberg</span></a><div hidden="hidden" id="id241"> <h3><span class="name western">Mark S Goldberg</span></h3> <div class="p"> <sup>178</sup>Department of Medicine, McGill University, Montreal, Quebec, Canada</div> <div class="p"> <sup>179</sup>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goldberg%20MS%22%5BAuthor%5D" class="usa-link"><span class="name western">Mark S Goldberg</span></a> </div> </div> <sup>178,</sup><sup>179</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yang%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id242"><span class="name western">Gong Yang</span></a><div hidden="hidden" id="id242"> <h3><span class="name western">Gong Yang</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yang%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">Gong Yang</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dumont%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id243"><span class="name western">Martine Dumont</span></a><div hidden="hidden" id="id243"> <h3><span class="name western">Martine Dumont</span></h3> <div class="p"> <sup>55</sup>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dumont%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Martine Dumont</span></a> </div> </div> <sup>55</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McLaughlin%20JR%22%5BAuthor%5D" class="usa-link" aria-describedby="id244"><span class="name western">John R McLaughlin</span></a><div hidden="hidden" id="id244"> <h3><span class="name western">John R McLaughlin</span></h3> <div class="p"> <sup>162</sup>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</div> <div class="p"> <sup>180</sup>Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McLaughlin%20JR%22%5BAuthor%5D" class="usa-link"><span class="name western">John R McLaughlin</span></a> </div> </div> <sup>162,</sup><sup>180</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hartmann%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id245"><span class="name western">Arndt Hartmann</span></a><div hidden="hidden" id="id245"> <h3><span class="name western">Arndt Hartmann</span></h3> <div class="p"> <sup>181</sup>Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hartmann%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Arndt Hartmann</span></a> </div> </div> <sup>181</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ekici%20AB%22%5BAuthor%5D" class="usa-link" aria-describedby="id246"><span class="name western">Arif B Ekici</span></a><div hidden="hidden" id="id246"> <h3><span class="name western">Arif B Ekici</span></h3> <div class="p"> <sup>182</sup>Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ekici%20AB%22%5BAuthor%5D" class="usa-link"><span class="name western">Arif B Ekici</span></a> </div> </div> <sup>182</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Beckmann%20MW%22%5BAuthor%5D" class="usa-link" aria-describedby="id247"><span class="name western">Matthias W Beckmann</span></a><div hidden="hidden" id="id247"> <h3><span class="name western">Matthias W Beckmann</span></h3> <div class="p"> <sup>57</sup>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Beckmann%20MW%22%5BAuthor%5D" class="usa-link"><span class="name western">Matthias W Beckmann</span></a> </div> </div> <sup>57</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Phelan%20CM%22%5BAuthor%5D" class="usa-link" aria-describedby="id248"><span class="name western">Catherine M Phelan</span></a><div hidden="hidden" id="id248"> <h3><span class="name western">Catherine M Phelan</span></h3> <div class="p"> <sup>12</sup>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Phelan%20CM%22%5BAuthor%5D" class="usa-link"><span class="name western">Catherine M Phelan</span></a> </div> </div> <sup>12</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lux%20MP%22%5BAuthor%5D" class="usa-link" aria-describedby="id249"><span class="name western">Michael P Lux</span></a><div hidden="hidden" id="id249"> <h3><span class="name western">Michael P Lux</span></h3> <div class="p"> <sup>57</sup>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lux%20MP%22%5BAuthor%5D" class="usa-link"><span class="name western">Michael P Lux</span></a> </div> </div> <sup>57</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Permuth-Wey%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id250"><span class="name western">Jenny Permuth-Wey</span></a><div hidden="hidden" id="id250"> <h3><span class="name western">Jenny Permuth-Wey</span></h3> <div class="p"> <sup>12</sup>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Permuth-Wey%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jenny Permuth-Wey</span></a> </div> </div> <sup>12</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peissel%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id251"><span class="name western">Bernard Peissel</span></a><div hidden="hidden" id="id251"> <h3><span class="name western">Bernard Peissel</span></h3> <div class="p"> <sup>183</sup>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peissel%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Bernard Peissel</span></a> </div> </div> <sup>183</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sellers%20TA%22%5BAuthor%5D" class="usa-link" aria-describedby="id252"><span class="name western">Thomas A Sellers</span></a><div hidden="hidden" id="id252"> <h3><span class="name western">Thomas A Sellers</span></h3> <div class="p"> <sup>12</sup>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sellers%20TA%22%5BAuthor%5D" class="usa-link"><span class="name western">Thomas A Sellers</span></a> </div> </div> <sup>12</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ficarazzi%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id253"><span class="name western">Filomena Ficarazzi</span></a><div hidden="hidden" id="id253"> <h3><span class="name western">Filomena Ficarazzi</span></h3> <div class="p"> <sup>59</sup>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</div> <div class="p"> <sup>184</sup>Cogentech Cancer Genetic Test Laboratory, Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ficarazzi%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">Filomena Ficarazzi</span></a> </div> </div> <sup>59,</sup><sup>184</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Barile%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id254"><span class="name western">Monica Barile</span></a><div hidden="hidden" id="id254"> <h3><span class="name western">Monica Barile</span></h3> <div class="p"> <sup>185</sup>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Barile%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Monica Barile</span></a> </div> </div> <sup>185</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ziogas%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id255"><span class="name western">Argyrios Ziogas</span></a><div hidden="hidden" id="id255"> <h3><span class="name western">Argyrios Ziogas</span></h3> <div class="p"> <sup>186</sup>Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ziogas%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Argyrios Ziogas</span></a> </div> </div> <sup>186</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ashworth%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id256"><span class="name western">Alan Ashworth</span></a><div hidden="hidden" id="id256"> <h3><span class="name western">Alan Ashworth</span></h3> <div class="p"> <sup>65</sup>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ashworth%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Alan Ashworth</span></a> </div> </div> <sup>65</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gentry-Maharaj%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id257"><span class="name western">Aleksandra Gentry-Maharaj</span></a><div hidden="hidden" id="id257"> <h3><span class="name western">Aleksandra Gentry-Maharaj</span></h3> <div class="p"> <sup>187</sup>Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gentry-Maharaj%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Aleksandra Gentry-Maharaj</span></a> </div> </div> <sup>187</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jones%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id258"><span class="name western">Michael Jones</span></a><div hidden="hidden" id="id258"> <h3><span class="name western">Michael Jones</span></h3> <div class="p"> <sup>60</sup>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jones%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Michael Jones</span></a> </div> </div> <sup>60</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ramus%20SJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id259"><span class="name western">Susan J Ramus</span></a><div hidden="hidden" id="id259"> <h3><span class="name western">Susan J Ramus</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ramus%20SJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Susan J Ramus</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orr%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id260"><span class="name western">Nick Orr</span></a><div hidden="hidden" id="id260"> <h3><span class="name western">Nick Orr</span></h3> <div class="p"> <sup>65</sup>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Orr%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nick Orr</span></a> </div> </div> <sup>65</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Menon%20U%22%5BAuthor%5D" class="usa-link" aria-describedby="id261"><span class="name western">Usha Menon</span></a><div hidden="hidden" id="id261"> <h3><span class="name western">Usha Menon</span></h3> <div class="p"> <sup>187</sup>Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, London, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Menon%20U%22%5BAuthor%5D" class="usa-link"><span class="name western">Usha Menon</span></a> </div> </div> <sup>187</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pearce%20CL%22%5BAuthor%5D" class="usa-link" aria-describedby="id262"><span class="name western">Celeste L Pearce</span></a><div hidden="hidden" id="id262"> <h3><span class="name western">Celeste L Pearce</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pearce%20CL%22%5BAuthor%5D" class="usa-link"><span class="name western">Celeste L Pearce</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Br%C3%BCning%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id263"><span class="name western">Thomas Brüning</span></a><div hidden="hidden" id="id263"> <h3><span class="name western">Thomas Brüning</span></h3> <div class="p"> <sup>188</sup>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum, Bochum, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Br%C3%BCning%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Thomas Brüning</span></a> </div> </div> <sup>188</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pike%20MC%22%5BAuthor%5D" class="usa-link" aria-describedby="id264"><span class="name western">Malcolm C Pike</span></a><div hidden="hidden" id="id264"> <h3><span class="name western">Malcolm C Pike</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p"> <sup>126</sup>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pike%20MC%22%5BAuthor%5D" class="usa-link"><span class="name western">Malcolm C Pike</span></a> </div> </div> <sup>9,</sup><sup>126</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ko%20YD%22%5BAuthor%5D" class="usa-link" aria-describedby="id265"><span class="name western">Yon-Dschun Ko</span></a><div hidden="hidden" id="id265"> <h3><span class="name western">Yon-Dschun Ko</span></h3> <div class="p"> <sup>189</sup>Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ko%20YD%22%5BAuthor%5D" class="usa-link"><span class="name western">Yon-Dschun Ko</span></a> </div> </div> <sup>189</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lissowska%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id266"><span class="name western">Jolanta Lissowska</span></a><div hidden="hidden" id="id266"> <h3><span class="name western">Jolanta Lissowska</span></h3> <div class="p"> <sup>190</sup>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lissowska%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jolanta Lissowska</span></a> </div> </div> <sup>190</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Figueroa%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id267"><span class="name western">Jonine Figueroa</span></a><div hidden="hidden" id="id267"> <h3><span class="name western">Jonine Figueroa</span></h3> <div class="p"> <sup>158</sup>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Figueroa%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jonine Figueroa</span></a> </div> </div> <sup>158</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kupryjanczyk%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id268"><span class="name western">Jolanta Kupryjanczyk</span></a><div hidden="hidden" id="id268"> <h3><span class="name western">Jolanta Kupryjanczyk</span></h3> <div class="p"> <sup>191</sup>Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kupryjanczyk%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jolanta Kupryjanczyk</span></a> </div> </div> <sup>191</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chanock%20SJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id269"><span class="name western">Stephen J Chanock</span></a><div hidden="hidden" id="id269"> <h3><span class="name western">Stephen J Chanock</span></h3> <div class="p"> <sup>158</sup>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chanock%20SJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Stephen J Chanock</span></a> </div> </div> <sup>158</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dansonka-Mieszkowska%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id270"><span class="name western">Agnieszka Dansonka-Mieszkowska</span></a><div hidden="hidden" id="id270"> <h3><span class="name western">Agnieszka Dansonka-Mieszkowska</span></h3> <div class="p"> <sup>191</sup>Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dansonka-Mieszkowska%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Agnieszka Dansonka-Mieszkowska</span></a> </div> </div> <sup>191</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jukkola-Vuorinen%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id271"><span class="name western">Arja Jukkola-Vuorinen</span></a><div hidden="hidden" id="id271"> <h3><span class="name western">Arja Jukkola-Vuorinen</span></h3> <div class="p"> <sup>192</sup>Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jukkola-Vuorinen%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Arja Jukkola-Vuorinen</span></a> </div> </div> <sup>192</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rzepecka%20IK%22%5BAuthor%5D" class="usa-link" aria-describedby="id272"><span class="name western">Iwona K Rzepecka</span></a><div hidden="hidden" id="id272"> <h3><span class="name western">Iwona K Rzepecka</span></h3> <div class="p"> <sup>191</sup>Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rzepecka%20IK%22%5BAuthor%5D" class="usa-link"><span class="name western">Iwona K Rzepecka</span></a> </div> </div> <sup>191</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pylk%C3%A4s%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id273"><span class="name western">Katri Pylkäs</span></a><div hidden="hidden" id="id273"> <h3><span class="name western">Katri Pylkäs</span></h3> <div class="p"> <sup>67</sup>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland</div> <div class="p"> <sup>68</sup>Biocenter Oulu, University of Oulu, Oulu, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pylk%C3%A4s%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Katri Pylkäs</span></a> </div> </div> <sup>67,</sup><sup>68</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bidzinski%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id274"><span class="name western">Mariusz Bidzinski</span></a><div hidden="hidden" id="id274"> <h3><span class="name western">Mariusz Bidzinski</span></h3> <div class="p"> <sup>193</sup>Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bidzinski%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Mariusz Bidzinski</span></a> </div> </div> <sup>193</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kauppila%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id275"><span class="name western">Saila Kauppila</span></a><div hidden="hidden" id="id275"> <h3><span class="name western">Saila Kauppila</span></h3> <div class="p"> <sup>194</sup>Department of Pathology, Oulu University Hospital, University of Oulu, Oulu, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kauppila%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Saila Kauppila</span></a> </div> </div> <sup>194</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hollestelle%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id276"><span class="name western">Antoinette Hollestelle</span></a><div hidden="hidden" id="id276"> <h3><span class="name western">Antoinette Hollestelle</span></h3> <div class="p"> <sup>195</sup>Family Cancer Clinic, Department of Medical Oncology, Erasmus MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hollestelle%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Antoinette Hollestelle</span></a> </div> </div> <sup>195</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Seynaeve%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id277"><span class="name western">Caroline Seynaeve</span></a><div hidden="hidden" id="id277"> <h3><span class="name western">Caroline Seynaeve</span></h3> <div class="p"> <sup>195</sup>Family Cancer Clinic, Department of Medical Oncology, Erasmus MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Seynaeve%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Caroline Seynaeve</span></a> </div> </div> <sup>195</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tollenaar%20RAEM%22%5BAuthor%5D" class="usa-link" aria-describedby="id278"><span class="name western">Rob A E M Tollenaar</span></a><div hidden="hidden" id="id278"> <h3><span class="name western">Rob A E M Tollenaar</span></h3> <div class="p"> <sup>196</sup>Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tollenaar%20RAEM%22%5BAuthor%5D" class="usa-link"><span class="name western">Rob A E M Tollenaar</span></a> </div> </div> <sup>196</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Durda%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id279"><span class="name western">Katarzyna Durda</span></a><div hidden="hidden" id="id279"> <h3><span class="name western">Katarzyna Durda</span></h3> <div class="p"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Durda%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Katarzyna Durda</span></a> </div> </div> <sup>72</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jaworska%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id280"><span class="name western">Katarzyna Jaworska</span></a><div hidden="hidden" id="id280"> <h3><span class="name western">Katarzyna Jaworska</span></h3> <div class="p"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div class="p"> <sup>197</sup>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jaworska%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Katarzyna Jaworska</span></a> </div> </div> <sup>72,</sup><sup>197</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hartikainen%20JM%22%5BAuthor%5D" class="usa-link" aria-describedby="id281"><span class="name western">Jaana M Hartikainen</span></a><div hidden="hidden" id="id281"> <h3><span class="name western">Jaana M Hartikainen</span></h3> <div class="p"> <sup>73</sup>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</div> <div class="p"> <sup>74</sup>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hartikainen%20JM%22%5BAuthor%5D" class="usa-link"><span class="name western">Jaana M Hartikainen</span></a> </div> </div> <sup>73,</sup><sup>74</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kosma%20VM%22%5BAuthor%5D" class="usa-link" aria-describedby="id282"><span class="name western">Veli-Matti Kosma</span></a><div hidden="hidden" id="id282"> <h3><span class="name western">Veli-Matti Kosma</span></h3> <div class="p"> <sup>73</sup>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</div> <div class="p"> <sup>74</sup>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kosma%20VM%22%5BAuthor%5D" class="usa-link"><span class="name western">Veli-Matti Kosma</span></a> </div> </div> <sup>73,</sup><sup>74</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kataja%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id283"><span class="name western">Vesa Kataja</span></a><div hidden="hidden" id="id283"> <h3><span class="name western">Vesa Kataja</span></h3> <div class="p"> <sup>74</sup>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kataja%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Vesa Kataja</span></a> </div> </div> <sup>74</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Antonenkova%20NN%22%5BAuthor%5D" class="usa-link" aria-describedby="id284"><span class="name western">Natalia N Antonenkova</span></a><div hidden="hidden" id="id284"> <h3><span class="name western">Natalia N Antonenkova</span></h3> <div class="p"> <sup>198</sup>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Antonenkova%20NN%22%5BAuthor%5D" class="usa-link"><span class="name western">Natalia N Antonenkova</span></a> </div> </div> <sup>198</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id285"><span class="name western">Jirong Long</span></a><div hidden="hidden" id="id285"> <h3><span class="name western">Jirong Long</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jirong Long</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shrubsole%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id286"><span class="name western">Martha Shrubsole</span></a><div hidden="hidden" id="id286"> <h3><span class="name western">Martha Shrubsole</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shrubsole%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Martha Shrubsole</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Deming-Halverson%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id287"><span class="name western">Sandra Deming-Halverson</span></a><div hidden="hidden" id="id287"> <h3><span class="name western">Sandra Deming-Halverson</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Deming-Halverson%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Sandra Deming-Halverson</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lophatananon%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id288"><span class="name western">Artitaya Lophatananon</span></a><div hidden="hidden" id="id288"> <h3><span class="name western">Artitaya Lophatananon</span></h3> <div class="p"> <sup>84</sup>Warwick Medical School, Warwick University, Coventry, UK</div> <div class="p"> <sup>85</sup>Institute of Population Health, University of Manchester, Manchester, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lophatananon%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Artitaya Lophatananon</span></a> </div> </div> <sup>84,</sup><sup>85</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Siriwanarangsan%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id289"><span class="name western">Pornthep Siriwanarangsan</span></a><div hidden="hidden" id="id289"> <h3><span class="name western">Pornthep Siriwanarangsan</span></h3> <div class="p"> <sup>199</sup>Ministry of Public Health, Thailand</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Siriwanarangsan%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Pornthep Siriwanarangsan</span></a> </div> </div> <sup>199</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stewart-Brown%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id290"><span class="name western">Sarah Stewart-Brown</span></a><div hidden="hidden" id="id290"> <h3><span class="name western">Sarah Stewart-Brown</span></h3> <div class="p"> <sup>84</sup>Warwick Medical School, Warwick University, Coventry, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stewart-Brown%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Sarah Stewart-Brown</span></a> </div> </div> <sup>84</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ditsch%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id291"><span class="name western">Nina Ditsch</span></a><div hidden="hidden" id="id291"> <h3><span class="name western">Nina Ditsch</span></h3> <div class="p"> <sup>200</sup>Department of Gynecology and Obstetrics, Ludwig-Maximilians-Universität, Munich, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ditsch%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Nina Ditsch</span></a> </div> </div> <sup>200</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lichtner%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id292"><span class="name western">Peter Lichtner</span></a><div hidden="hidden" id="id292"> <h3><span class="name western">Peter Lichtner</span></h3> <div class="p"> <sup>201</sup>Insitute of Human Genetics, Technische Universität, Munich, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lichtner%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Peter Lichtner</span></a> </div> </div> <sup>201</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schmutzler%20RK%22%5BAuthor%5D" class="usa-link" aria-describedby="id293"><span class="name western">Rita K Schmutzler</span></a><div hidden="hidden" id="id293"> <h3><span class="name western">Rita K Schmutzler</span></h3> <div class="p"> <sup>202</sup>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</div> <div class="p"> <sup>203</sup>Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Schmutzler%20RK%22%5BAuthor%5D" class="usa-link"><span class="name western">Rita K Schmutzler</span></a> </div> </div> <sup>202,</sup><sup>203</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ito%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id294"><span class="name western">Hidemi Ito</span></a><div hidden="hidden" id="id294"> <h3><span class="name western">Hidemi Ito</span></h3> <div class="p"> <sup>90</sup>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ito%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hidemi Ito</span></a> </div> </div> <sup>90</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iwata%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id295"><span class="name western">Hiroji Iwata</span></a><div hidden="hidden" id="id295"> <h3><span class="name western">Hiroji Iwata</span></h3> <div class="p"> <sup>204</sup>Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iwata%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hiroji Iwata</span></a> </div> </div> <sup>204</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tajima%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id296"><span class="name western">Kazuo Tajima</span></a><div hidden="hidden" id="id296"> <h3><span class="name western">Kazuo Tajima</span></h3> <div class="p"> <sup>90</sup>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tajima%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kazuo Tajima</span></a> </div> </div> <sup>90</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tseng%20CC%22%5BAuthor%5D" class="usa-link" aria-describedby="id297"><span class="name western">Chiu-Chen Tseng</span></a><div hidden="hidden" id="id297"> <h3><span class="name western">Chiu-Chen Tseng</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tseng%20CC%22%5BAuthor%5D" class="usa-link"><span class="name western">Chiu-Chen Tseng</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stram%20DO%22%5BAuthor%5D" class="usa-link" aria-describedby="id298"><span class="name western">Daniel O Stram</span></a><div hidden="hidden" id="id298"> <h3><span class="name western">Daniel O Stram</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stram%20DO%22%5BAuthor%5D" class="usa-link"><span class="name western">Daniel O Stram</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20den%20Berg%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id299"><span class="name western">David van den Berg</span></a><div hidden="hidden" id="id299"> <h3><span class="name western">David van den Berg</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20den%20Berg%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">David van den Berg</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yip%20CH%22%5BAuthor%5D" class="usa-link" aria-describedby="id300"><span class="name western">Cheng Har Yip</span></a><div hidden="hidden" id="id300"> <h3><span class="name western">Cheng Har Yip</span></h3> <div class="p"> <sup>92</sup>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yip%20CH%22%5BAuthor%5D" class="usa-link"><span class="name western">Cheng Har Yip</span></a> </div> </div> <sup>92</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ikram%20MK%22%5BAuthor%5D" class="usa-link" aria-describedby="id301"><span class="name western">M Kamran Ikram</span></a><div hidden="hidden" id="id301"> <h3><span class="name western">M Kamran Ikram</span></h3> <div class="p"> <sup>205</sup>Singapore Eye Research Institute, National University of Singapore, Singapore</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ikram%20MK%22%5BAuthor%5D" class="usa-link"><span class="name western">M Kamran Ikram</span></a> </div> </div> <sup>205</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teh%20YC%22%5BAuthor%5D" class="usa-link" aria-describedby="id302"><span class="name western">Yew-Ching Teh</span></a><div hidden="hidden" id="id302"> <h3><span class="name western">Yew-Ching Teh</span></h3> <div class="p"> <sup>92</sup>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teh%20YC%22%5BAuthor%5D" class="usa-link"><span class="name western">Yew-Ching Teh</span></a> </div> </div> <sup>92</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cai%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id303"><span class="name western">Hui Cai</span></a><div hidden="hidden" id="id303"> <h3><span class="name western">Hui Cai</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cai%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hui Cai</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lu%20W%22%5BAuthor%5D" class="usa-link" aria-describedby="id304"><span class="name western">Wei Lu</span></a><div hidden="hidden" id="id304"> <h3><span class="name western">Wei Lu</span></h3> <div class="p"> <sup>206</sup>Shanghai Center for Disease Control and Prevention, Shanghai, China</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lu%20W%22%5BAuthor%5D" class="usa-link"><span class="name western">Wei Lu</span></a> </div> </div> <sup>206</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Signorello%20LB%22%5BAuthor%5D" class="usa-link" aria-describedby="id305"><span class="name western">Lisa B Signorello</span></a><div hidden="hidden" id="id305"> <h3><span class="name western">Lisa B Signorello</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p"> <sup>94</sup>International Epidemiology Institute, Rockville, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Signorello%20LB%22%5BAuthor%5D" class="usa-link"><span class="name western">Lisa B Signorello</span></a> </div> </div> <sup>78,</sup><sup>94</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cai%20Q%22%5BAuthor%5D" class="usa-link" aria-describedby="id306"><span class="name western">Qiuyin Cai</span></a><div hidden="hidden" id="id306"> <h3><span class="name western">Qiuyin Cai</span></h3> <div class="p"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cai%20Q%22%5BAuthor%5D" class="usa-link"><span class="name western">Qiuyin Cai</span></a> </div> </div> <sup>78</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Noh%20DY%22%5BAuthor%5D" class="usa-link" aria-describedby="id307"><span class="name western">Dong-Young Noh</span></a><div hidden="hidden" id="id307"> <h3><span class="name western">Dong-Young Noh</span></h3> <div class="p"> <sup>95</sup>Seoul National University College of Medicine, Seoul, Korea</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Noh%20DY%22%5BAuthor%5D" class="usa-link"><span class="name western">Dong-Young Noh</span></a> </div> </div> <sup>95</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yoo%20KY%22%5BAuthor%5D" class="usa-link" aria-describedby="id308"><span class="name western">Keun-Young Yoo</span></a><div hidden="hidden" id="id308"> <h3><span class="name western">Keun-Young Yoo</span></h3> <div class="p"> <sup>95</sup>Seoul National University College of Medicine, Seoul, Korea</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yoo%20KY%22%5BAuthor%5D" class="usa-link"><span class="name western">Keun-Young Yoo</span></a> </div> </div> <sup>95</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Miao%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id309"><span class="name western">Hui Miao</span></a><div hidden="hidden" id="id309"> <h3><span class="name western">Hui Miao</span></h3> <div class="p"> <sup>98</sup>Saw Swee Hock School of Public Health, National University of Singapore</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Miao%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hui Miao</span></a> </div> </div> <sup>98</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iau%20PTC%22%5BAuthor%5D" class="usa-link" aria-describedby="id310"><span class="name western">Philip Tsau-Choong Iau</span></a><div hidden="hidden" id="id310"> <h3><span class="name western">Philip Tsau-Choong Iau</span></h3> <div class="p"> <sup>97</sup>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Iau%20PTC%22%5BAuthor%5D" class="usa-link"><span class="name western">Philip Tsau-Choong Iau</span></a> </div> </div> <sup>97</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teo%20YY%22%5BAuthor%5D" class="usa-link" aria-describedby="id311"><span class="name western">Yik Ying Teo</span></a><div hidden="hidden" id="id311"> <h3><span class="name western">Yik Ying Teo</span></h3> <div class="p"> <sup>98</sup>Saw Swee Hock School of Public Health, National University of Singapore</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Teo%20YY%22%5BAuthor%5D" class="usa-link"><span class="name western">Yik Ying Teo</span></a> </div> </div> <sup>98</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McKay%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id312"><span class="name western">James McKay</span></a><div hidden="hidden" id="id312"> <h3><span class="name western">James McKay</span></h3> <div class="p"> <sup>105</sup>International Agency for Research on Cancer, Lyon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22McKay%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">James McKay</span></a> </div> </div> <sup>105</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shapiro%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id313"><span class="name western">Charles Shapiro</span></a><div hidden="hidden" id="id313"> <h3><span class="name western">Charles Shapiro</span></h3> <div class="p"> <sup>207</sup>Division of Oncology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Shapiro%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Charles Shapiro</span></a> </div> </div> <sup>207</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ademuyiwa%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id314"><span class="name western">Foluso Ademuyiwa</span></a><div hidden="hidden" id="id314"> <h3><span class="name western">Foluso Ademuyiwa</span></h3> <div class="p"> <sup>208</sup>Roswell Park Cancer Institute, Buffalo, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ademuyiwa%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">Foluso Ademuyiwa</span></a> </div> </div> <sup>208</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fountzilas%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id315"><span class="name western">George Fountzilas</span></a><div hidden="hidden" id="id315"> <h3><span class="name western">George Fountzilas</span></h3> <div class="p"> <sup>209</sup>Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Macedonia, Greece</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fountzilas%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">George Fountzilas</span></a> </div> </div> <sup>209</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hsiung%20CN%22%5BAuthor%5D" class="usa-link" aria-describedby="id316"><span class="name western">Chia-Ni Hsiung</span></a><div hidden="hidden" id="id316"> <h3><span class="name western">Chia-Ni Hsiung</span></h3> <div class="p"> <sup>109</sup>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hsiung%20CN%22%5BAuthor%5D" class="usa-link"><span class="name western">Chia-Ni Hsiung</span></a> </div> </div> <sup>109</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yu%20JC%22%5BAuthor%5D" class="usa-link" aria-describedby="id317"><span class="name western">Jyh-Cherng Yu</span></a><div hidden="hidden" id="id317"> <h3><span class="name western">Jyh-Cherng Yu</span></h3> <div class="p"> <sup>210</sup>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yu%20JC%22%5BAuthor%5D" class="usa-link"><span class="name western">Jyh-Cherng Yu</span></a> </div> </div> <sup>210</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hou%20MF%22%5BAuthor%5D" class="usa-link" aria-describedby="id318"><span class="name western">Ming-Feng Hou</span></a><div hidden="hidden" id="id318"> <h3><span class="name western">Ming-Feng Hou</span></h3> <div class="p"> <sup>211</sup>Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</div> <div class="p"> <sup>212</sup>Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hou%20MF%22%5BAuthor%5D" class="usa-link"><span class="name western">Ming-Feng Hou</span></a> </div> </div> <sup>211,</sup><sup>212</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Healey%20CS%22%5BAuthor%5D" class="usa-link" aria-describedby="id319"><span class="name western">Catherine S Healey</span></a><div hidden="hidden" id="id319"> <h3><span class="name western">Catherine S Healey</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Healey%20CS%22%5BAuthor%5D" class="usa-link"><span class="name western">Catherine S Healey</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Luccarini%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id320"><span class="name western">Craig Luccarini</span></a><div hidden="hidden" id="id320"> <h3><span class="name western">Craig Luccarini</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Luccarini%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Craig Luccarini</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peock%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id321"><span class="name western">Susan Peock</span></a><div hidden="hidden" id="id321"> <h3><span class="name western">Susan Peock</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peock%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Susan Peock</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stoppa-Lyonnet%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id322"><span class="name western">Dominique Stoppa-Lyonnet</span></a><div hidden="hidden" id="id322"> <h3><span class="name western">Dominique Stoppa-Lyonnet</span></h3> <div class="p"> <sup>213</sup>Institut Curie, Department of Tumour Biology, Paris, France</div> <div class="p"> <sup>214</sup>Institut Curie, INSERM U830, Paris, France</div> <div class="p"> <sup>215</sup>Université Paris Descartes, Sorbonne Paris Cité, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Stoppa-Lyonnet%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Dominique Stoppa-Lyonnet</span></a> </div> </div> <sup>213,</sup><sup>214,</sup><sup>215</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peterlongo%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id323"><span class="name western">Paolo Peterlongo</span></a><div hidden="hidden" id="id323"> <h3><span class="name western">Paolo Peterlongo</span></h3> <div class="p"> <sup>58</sup>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</div> <div class="p"> <sup>59</sup>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Peterlongo%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Paolo Peterlongo</span></a> </div> </div> <sup>58,</sup><sup>59</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rebbeck%20TR%22%5BAuthor%5D" class="usa-link" aria-describedby="id324"><span class="name western">Timothy R Rebbeck</span></a><div hidden="hidden" id="id324"> <h3><span class="name western">Timothy R Rebbeck</span></h3> <div class="p"> <sup>216</sup>Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</div> <div class="p"> <sup>217</sup>Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rebbeck%20TR%22%5BAuthor%5D" class="usa-link"><span class="name western">Timothy R Rebbeck</span></a> </div> </div> <sup>216,</sup><sup>217</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Piedmonte%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id325"><span class="name western">Marion Piedmonte</span></a><div hidden="hidden" id="id325"> <h3><span class="name western">Marion Piedmonte</span></h3> <div class="p"> <sup>218</sup>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Piedmonte%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Marion Piedmonte</span></a> </div> </div> <sup>218</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Singer%20CF%22%5BAuthor%5D" class="usa-link" aria-describedby="id326"><span class="name western">Christian F Singer</span></a><div hidden="hidden" id="id326"> <h3><span class="name western">Christian F Singer</span></h3> <div class="p"> <sup>219</sup>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Singer%20CF%22%5BAuthor%5D" class="usa-link"><span class="name western">Christian F Singer</span></a> </div> </div> <sup>219</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Friedman%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id327"><span class="name western">Eitan Friedman</span></a><div hidden="hidden" id="id327"> <h3><span class="name western">Eitan Friedman</span></h3> <div class="p"> <sup>220</sup>The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</div> <div class="p"> <sup>221</sup>Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Friedman%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Eitan Friedman</span></a> </div> </div> <sup>220,</sup><sup>221</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thomassen%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id328"><span class="name western">Mads Thomassen</span></a><div hidden="hidden" id="id328"> <h3><span class="name western">Mads Thomassen</span></h3> <div class="p"> <sup>222</sup>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Thomassen%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Mads Thomassen</span></a> </div> </div> <sup>222</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Offit%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id329"><span class="name western">Kenneth Offit</span></a><div hidden="hidden" id="id329"> <h3><span class="name western">Kenneth Offit</span></h3> <div class="p"> <sup>223</sup>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Offit%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kenneth Offit</span></a> </div> </div> <sup>223</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hansen%20TVO%22%5BAuthor%5D" class="usa-link" aria-describedby="id330"><span class="name western">Thomas V O Hansen</span></a><div hidden="hidden" id="id330"> <h3><span class="name western">Thomas V O Hansen</span></h3> <div class="p"> <sup>224</sup>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hansen%20TVO%22%5BAuthor%5D" class="usa-link"><span class="name western">Thomas V O Hansen</span></a> </div> </div> <sup>224</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuhausen%20SL%22%5BAuthor%5D" class="usa-link" aria-describedby="id331"><span class="name western">Susan L Neuhausen</span></a><div hidden="hidden" id="id331"> <h3><span class="name western">Susan L Neuhausen</span></h3> <div class="p"> <sup>225</sup>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Neuhausen%20SL%22%5BAuthor%5D" class="usa-link"><span class="name western">Susan L Neuhausen</span></a> </div> </div> <sup>225</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Szabo%20CI%22%5BAuthor%5D" class="usa-link" aria-describedby="id332"><span class="name western">Csilla I Szabo</span></a><div hidden="hidden" id="id332"> <h3><span class="name western">Csilla I Szabo</span></h3> <div class="p"> <sup>226</sup>Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, DE, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Szabo%20CI%22%5BAuthor%5D" class="usa-link"><span class="name western">Csilla I Szabo</span></a> </div> </div> <sup>226</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Blanco%20I%22%5BAuthor%5D" class="usa-link" aria-describedby="id333"><span class="name western">Ignacio Blanco</span></a><div hidden="hidden" id="id333"> <h3><span class="name western">Ignacio Blanco</span></h3> <div class="p"> <sup>227</sup>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Blanco%20I%22%5BAuthor%5D" class="usa-link"><span class="name western">Ignacio Blanco</span></a> </div> </div> <sup>227</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Garber%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id334"><span class="name western">Judy Garber</span></a><div hidden="hidden" id="id334"> <h3><span class="name western">Judy Garber</span></h3> <div class="p"> <sup>228</sup>Dana-Farber Cancer Institute, Boston, MA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Garber%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Judy Garber</span></a> </div> </div> <sup>228</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Narod%20SA%22%5BAuthor%5D" class="usa-link" aria-describedby="id335"><span class="name western">Steven A Narod</span></a><div hidden="hidden" id="id335"> <h3><span class="name western">Steven A Narod</span></h3> <div class="p"> <sup>229</sup>Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Narod%20SA%22%5BAuthor%5D" class="usa-link"><span class="name western">Steven A Narod</span></a> </div> </div> <sup>229</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Weitzel%20JN%22%5BAuthor%5D" class="usa-link" aria-describedby="id336"><span class="name western">Jeffrey N Weitzel</span></a><div hidden="hidden" id="id336"> <h3><span class="name western">Jeffrey N Weitzel</span></h3> <div class="p"> <sup>230</sup>Clinical Cancer Genetics, City of Hope, Duarte, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Weitzel%20JN%22%5BAuthor%5D" class="usa-link"><span class="name western">Jeffrey N Weitzel</span></a> </div> </div> <sup>230</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Montagna%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id337"><span class="name western">Marco Montagna</span></a><div hidden="hidden" id="id337"> <h3><span class="name western">Marco Montagna</span></h3> <div class="p"> <sup>231</sup>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Montagna%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Marco Montagna</span></a> </div> </div> <sup>231</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olah%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id338"><span class="name western">Edith Olah</span></a><div hidden="hidden" id="id338"> <h3><span class="name western">Edith Olah</span></h3> <div class="p"> <sup>232</sup>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olah%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Edith Olah</span></a> </div> </div> <sup>232</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Godwin%20AK%22%5BAuthor%5D" class="usa-link" aria-describedby="id339"><span class="name western">Andrew K Godwin</span></a><div hidden="hidden" id="id339"> <h3><span class="name western">Andrew K Godwin</span></h3> <div class="p"> <sup>233</sup>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Godwin%20AK%22%5BAuthor%5D" class="usa-link"><span class="name western">Andrew K Godwin</span></a> </div> </div> <sup>233</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yannoukakos%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id340"><span class="name western">Drakoulis Yannoukakos</span></a><div hidden="hidden" id="id340"> <h3><span class="name western">Drakoulis Yannoukakos</span></h3> <div class="p"> <sup>234</sup>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Yannoukakos%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Drakoulis Yannoukakos</span></a> </div> </div> <sup>234</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goldgar%20DE%22%5BAuthor%5D" class="usa-link" aria-describedby="id341"><span class="name western">David E Goldgar</span></a><div hidden="hidden" id="id341"> <h3><span class="name western">David E Goldgar</span></h3> <div class="p"> <sup>235</sup>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA</div> <div class="p"> <sup>236</sup>Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goldgar%20DE%22%5BAuthor%5D" class="usa-link"><span class="name western">David E Goldgar</span></a> </div> </div> <sup>235,</sup><sup>236</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Caldes%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id342"><span class="name western">Trinidad Caldes</span></a><div hidden="hidden" id="id342"> <h3><span class="name western">Trinidad Caldes</span></h3> <div class="p"> <sup>237</sup>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Caldes%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Trinidad Caldes</span></a> </div> </div> <sup>237</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Imyanitov%20EN%22%5BAuthor%5D" class="usa-link" aria-describedby="id343"><span class="name western">Evgeny N Imyanitov</span></a><div hidden="hidden" id="id343"> <h3><span class="name western">Evgeny N Imyanitov</span></h3> <div class="p"> <sup>238</sup>N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Imyanitov%20EN%22%5BAuthor%5D" class="usa-link"><span class="name western">Evgeny N Imyanitov</span></a> </div> </div> <sup>238</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tihomirova%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id344"><span class="name western">Laima Tihomirova</span></a><div hidden="hidden" id="id344"> <h3><span class="name western">Laima Tihomirova</span></h3> <div class="p"> <sup>239</sup>Latvian Biomedical Research and Study Centre, Riga, Latvia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tihomirova%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Laima Tihomirova</span></a> </div> </div> <sup>239</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Arun%20BK%22%5BAuthor%5D" class="usa-link" aria-describedby="id345"><span class="name western">Banu K Arun</span></a><div hidden="hidden" id="id345"> <h3><span class="name western">Banu K Arun</span></h3> <div class="p"> <sup>240</sup>Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA</div> <div class="p"> <sup>241</sup>Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Arun%20BK%22%5BAuthor%5D" class="usa-link"><span class="name western">Banu K Arun</span></a> </div> </div> <sup>240,</sup><sup>241</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Campbell%20I%22%5BAuthor%5D" class="usa-link" aria-describedby="id346"><span class="name western">Ian Campbell</span></a><div hidden="hidden" id="id346"> <h3><span class="name western">Ian Campbell</span></h3> <div class="p"> <sup>242</sup>VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Campbell%20I%22%5BAuthor%5D" class="usa-link"><span class="name western">Ian Campbell</span></a> </div> </div> <sup>242</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mensenkamp%20AR%22%5BAuthor%5D" class="usa-link" aria-describedby="id347"><span class="name western">Arjen R Mensenkamp</span></a><div hidden="hidden" id="id347"> <h3><span class="name western">Arjen R Mensenkamp</span></h3> <div class="p"> <sup>243</sup>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mensenkamp%20AR%22%5BAuthor%5D" class="usa-link"><span class="name western">Arjen R Mensenkamp</span></a> </div> </div> <sup>243</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Asperen%20CJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id348"><span class="name western">Christi J van Asperen</span></a><div hidden="hidden" id="id348"> <h3><span class="name western">Christi J van Asperen</span></h3> <div class="p"> <sup>244</sup>Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Asperen%20CJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Christi J van Asperen</span></a> </div> </div> <sup>244</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Roozendaal%20KEP%22%5BAuthor%5D" class="usa-link" aria-describedby="id349"><span class="name western">Kees E P van Roozendaal</span></a><div hidden="hidden" id="id349"> <h3><span class="name western">Kees E P van Roozendaal</span></h3> <div class="p"> <sup>245</sup>Department of Clinical Genetics, Maastricht University Medical Canter, Maastricht, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Roozendaal%20KEP%22%5BAuthor%5D" class="usa-link"><span class="name western">Kees E P van Roozendaal</span></a> </div> </div> <sup>245</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Meijers-Heijboer%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id350"><span class="name western">Hanne Meijers-Heijboer</span></a><div hidden="hidden" id="id350"> <h3><span class="name western">Hanne Meijers-Heijboer</span></h3> <div class="p"> <sup>246</sup>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Meijers-Heijboer%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hanne Meijers-Heijboer</span></a> </div> </div> <sup>246</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Coll%C3%A9e%20JM%22%5BAuthor%5D" class="usa-link" aria-describedby="id351"><span class="name western">J Margriet Collée</span></a><div hidden="hidden" id="id351"> <h3><span class="name western">J Margriet Collée</span></h3> <div class="p"> <sup>247</sup>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Coll%C3%A9e%20JM%22%5BAuthor%5D" class="usa-link"><span class="name western">J Margriet Collée</span></a> </div> </div> <sup>247</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Oosterwijk%20JC%22%5BAuthor%5D" class="usa-link" aria-describedby="id352"><span class="name western">Jan C Oosterwijk</span></a><div hidden="hidden" id="id352"> <h3><span class="name western">Jan C Oosterwijk</span></h3> <div class="p"> <sup>248</sup>University of Groningen, University Medical Center, Department of Genetics, Groningen, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Oosterwijk%20JC%22%5BAuthor%5D" class="usa-link"><span class="name western">Jan C Oosterwijk</span></a> </div> </div> <sup>248</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hooning%20MJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id353"><span class="name western">Maartje J Hooning</span></a><div hidden="hidden" id="id353"> <h3><span class="name western">Maartje J Hooning</span></h3> <div class="p"> <sup>249</sup>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hooning%20MJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Maartje J Hooning</span></a> </div> </div> <sup>249</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rookus%20MA%22%5BAuthor%5D" class="usa-link" aria-describedby="id354"><span class="name western">Matti A Rookus</span></a><div hidden="hidden" id="id354"> <h3><span class="name western">Matti A Rookus</span></h3> <div class="p"> <sup>29</sup>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rookus%20MA%22%5BAuthor%5D" class="usa-link"><span class="name western">Matti A Rookus</span></a> </div> </div> <sup>29</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20der%20Luijt%20RB%22%5BAuthor%5D" class="usa-link" aria-describedby="id355"><span class="name western">Rob B van der Luijt</span></a><div hidden="hidden" id="id355"> <h3><span class="name western">Rob B van der Luijt</span></h3> <div class="p"> <sup>250</sup>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20der%20Luijt%20RB%22%5BAuthor%5D" class="usa-link"><span class="name western">Rob B van der Luijt</span></a> </div> </div> <sup>250</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Os%20TAM%22%5BAuthor%5D" class="usa-link" aria-describedby="id356"><span class="name western">Theo A M van Os</span></a><div hidden="hidden" id="id356"> <h3><span class="name western">Theo A M van Os</span></h3> <div class="p"> <sup>251</sup>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22van%20Os%20TAM%22%5BAuthor%5D" class="usa-link"><span class="name western">Theo A M van Os</span></a> </div> </div> <sup>251</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Evans%20DG%22%5BAuthor%5D" class="usa-link" aria-describedby="id357"><span class="name western">D Gareth Evans</span></a><div hidden="hidden" id="id357"> <h3><span class="name western">D Gareth Evans</span></h3> <div class="p"> <sup>252</sup>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Evans%20DG%22%5BAuthor%5D" class="usa-link"><span class="name western">D Gareth Evans</span></a> </div> </div> <sup>252</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frost%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id358"><span class="name western">Debra Frost</span></a><div hidden="hidden" id="id358"> <h3><span class="name western">Debra Frost</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frost%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Debra Frost</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fineberg%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id359"><span class="name western">Elena Fineberg</span></a><div hidden="hidden" id="id359"> <h3><span class="name western">Elena Fineberg</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Fineberg%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Elena Fineberg</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Barwell%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id360"><span class="name western">Julian Barwell</span></a><div hidden="hidden" id="id360"> <h3><span class="name western">Julian Barwell</span></h3> <div class="p"> <sup>253</sup>Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Barwell%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Julian Barwell</span></a> </div> </div> <sup>253</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Walker%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id361"><span class="name western">Lisa Walker</span></a><div hidden="hidden" id="id361"> <h3><span class="name western">Lisa Walker</span></h3> <div class="p"> <sup>254</sup>Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Walker%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Lisa Walker</span></a> </div> </div> <sup>254</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kennedy%20MJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id362"><span class="name western">M John Kennedy</span></a><div hidden="hidden" id="id362"> <h3><span class="name western">M John Kennedy</span></h3> <div class="p"> <sup>255</sup>Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kennedy%20MJ%22%5BAuthor%5D" class="usa-link"><span class="name western">M John Kennedy</span></a> </div> </div> <sup>255</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Platte%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id363"><span class="name western">Radka Platte</span></a><div hidden="hidden" id="id363"> <h3><span class="name western">Radka Platte</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Platte%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Radka Platte</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Davidson%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id364"><span class="name western">Rosemarie Davidson</span></a><div hidden="hidden" id="id364"> <h3><span class="name western">Rosemarie Davidson</span></h3> <div class="p"> <sup>256</sup>Laboratory Medicine at Southern General Hospital, Glasgow, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Davidson%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Rosemarie Davidson</span></a> </div> </div> <sup>256</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ellis%20SD%22%5BAuthor%5D" class="usa-link" aria-describedby="id365"><span class="name western">Steve D Ellis</span></a><div hidden="hidden" id="id365"> <h3><span class="name western">Steve D Ellis</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ellis%20SD%22%5BAuthor%5D" class="usa-link"><span class="name western">Steve D Ellis</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cole%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id366"><span class="name western">Trevor Cole</span></a><div hidden="hidden" id="id366"> <h3><span class="name western">Trevor Cole</span></h3> <div class="p"> <sup>257</sup>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cole%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Trevor Cole</span></a> </div> </div> <sup>257</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paillerets%20BBD%22%5BAuthor%5D" class="usa-link" aria-describedby="id367"><span class="name western">Brigitte Bressac-de Paillerets</span></a><div hidden="hidden" id="id367"> <h3><span class="name western">Brigitte Bressac-de Paillerets</span></h3> <div class="p"> <sup>258</sup>INSERM U946, Fondation Jean Dausset, Paris, France</div> <div class="p"> <sup>259</sup>Service de Génétique, Institut de Cancérologie Gustave Roussy, Villejuif, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paillerets%20BBD%22%5BAuthor%5D" class="usa-link"><span class="name western">Brigitte Bressac-de Paillerets</span></a> </div> </div> <sup>258,</sup><sup>259</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Buecher%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id368"><span class="name western">Bruno Buecher</span></a><div hidden="hidden" id="id368"> <h3><span class="name western">Bruno Buecher</span></h3> <div class="p"> <sup>213</sup>Institut Curie, Department of Tumour Biology, Paris, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Buecher%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Bruno Buecher</span></a> </div> </div> <sup>213</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Damiola%20F%22%5BAuthor%5D" class="usa-link" aria-describedby="id369"><span class="name western">Francesca Damiola</span></a><div hidden="hidden" id="id369"> <h3><span class="name western">Francesca Damiola</span></h3> <div class="p"> <sup>260</sup>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Damiola%20F%22%5BAuthor%5D" class="usa-link"><span class="name western">Francesca Damiola</span></a> </div> </div> <sup>260</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Faivre%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id370"><span class="name western">Laurence Faivre</span></a><div hidden="hidden" id="id370"> <h3><span class="name western">Laurence Faivre</span></h3> <div class="p"> <sup>261</sup>Centre de Génétique, CHU Dijon, Université de Bourgogne, Dijon, France, and Centre Georges François Leclerc, Dijon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Faivre%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Laurence Faivre</span></a> </div> </div> <sup>261</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frenay%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id371"><span class="name western">Marc Frenay</span></a><div hidden="hidden" id="id371"> <h3><span class="name western">Marc Frenay</span></h3> <div class="p"> <sup>262</sup>Centre Antoine Lacassagne, Nice, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Frenay%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Marc Frenay</span></a> </div> </div> <sup>262</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinilnikova%20OM%22%5BAuthor%5D" class="usa-link" aria-describedby="id372"><span class="name western">Olga M Sinilnikova</span></a><div hidden="hidden" id="id372"> <h3><span class="name western">Olga M Sinilnikova</span></h3> <div class="p"> <sup>260</sup>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</div> <div class="p"> <sup>263</sup>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Léon Bérard, Lyon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sinilnikova%20OM%22%5BAuthor%5D" class="usa-link"><span class="name western">Olga M Sinilnikova</span></a> </div> </div> <sup>260,</sup><sup>263</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Caron%20O%22%5BAuthor%5D" class="usa-link" aria-describedby="id373"><span class="name western">Olivier Caron</span></a><div hidden="hidden" id="id373"> <h3><span class="name western">Olivier Caron</span></h3> <div class="p"> <sup>264</sup>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Caron%20O%22%5BAuthor%5D" class="usa-link"><span class="name western">Olivier Caron</span></a> </div> </div> <sup>264</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giraud%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id374"><span class="name western">Sophie Giraud</span></a><div hidden="hidden" id="id374"> <h3><span class="name western">Sophie Giraud</span></h3> <div class="p"> <sup>263</sup>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Léon Bérard, Lyon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giraud%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Sophie Giraud</span></a> </div> </div> <sup>263</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mazoyer%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id375"><span class="name western">Sylvie Mazoyer</span></a><div hidden="hidden" id="id375"> <h3><span class="name western">Sylvie Mazoyer</span></h3> <div class="p"> <sup>260</sup>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Mazoyer%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Sylvie Mazoyer</span></a> </div> </div> <sup>260</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bonadona%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id376"><span class="name western">Valérie Bonadona</span></a><div hidden="hidden" id="id376"> <h3><span class="name western">Valérie Bonadona</span></h3> <div class="p"> <sup>265</sup>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</div> <div class="p"> <sup>266</sup>Université Lyon 1, CNRS UMR5558, Lyon, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bonadona%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Valérie Bonadona</span></a> </div> </div> <sup>265,</sup><sup>266</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Caux-Moncoutier%20V%22%5BAuthor%5D" class="usa-link" aria-describedby="id377"><span class="name western">Virginie Caux-Moncoutier</span></a><div hidden="hidden" id="id377"> <h3><span class="name western">Virginie Caux-Moncoutier</span></h3> <div class="p"> <sup>213</sup>Institut Curie, Department of Tumour Biology, Paris, France</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Caux-Moncoutier%20V%22%5BAuthor%5D" class="usa-link"><span class="name western">Virginie Caux-Moncoutier</span></a> </div> </div> <sup>213</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Toloczko-Grabarek%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id378"><span class="name western">Aleksandra Toloczko-Grabarek</span></a><div hidden="hidden" id="id378"> <h3><span class="name western">Aleksandra Toloczko-Grabarek</span></h3> <div class="p"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Toloczko-Grabarek%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Aleksandra Toloczko-Grabarek</span></a> </div> </div> <sup>72</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gronwald%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id379"><span class="name western">Jacek Gronwald</span></a><div hidden="hidden" id="id379"> <h3><span class="name western">Jacek Gronwald</span></h3> <div class="p"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gronwald%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jacek Gronwald</span></a> </div> </div> <sup>72</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Byrski%20T%22%5BAuthor%5D" class="usa-link" aria-describedby="id380"><span class="name western">Tomasz Byrski</span></a><div hidden="hidden" id="id380"> <h3><span class="name western">Tomasz Byrski</span></h3> <div class="p"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Byrski%20T%22%5BAuthor%5D" class="usa-link"><span class="name western">Tomasz Byrski</span></a> </div> </div> <sup>72</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Spurdle%20AB%22%5BAuthor%5D" class="usa-link" aria-describedby="id381"><span class="name western">Amanda B Spurdle</span></a><div hidden="hidden" id="id381"> <h3><span class="name western">Amanda B Spurdle</span></h3> <div class="p"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Spurdle%20AB%22%5BAuthor%5D" class="usa-link"><span class="name western">Amanda B Spurdle</span></a> </div> </div> <sup>4</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bonanni%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id382"><span class="name western">Bernardo Bonanni</span></a><div hidden="hidden" id="id382"> <h3><span class="name western">Bernardo Bonanni</span></h3> <div class="p"> <sup>185</sup>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bonanni%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Bernardo Bonanni</span></a> </div> </div> <sup>185</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zaffaroni%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id383"><span class="name western">Daniela Zaffaroni</span></a><div hidden="hidden" id="id383"> <h3><span class="name western">Daniela Zaffaroni</span></h3> <div class="p"> <sup>183</sup>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zaffaroni%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Daniela Zaffaroni</span></a> </div> </div> <sup>183</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giannini%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id384"><span class="name western">Giuseppe Giannini</span></a><div hidden="hidden" id="id384"> <h3><span class="name western">Giuseppe Giannini</span></h3> <div class="p"> <sup>267</sup>Department of Molecular Medicine, Sapienza University, Rome, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Giannini%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">Giuseppe Giannini</span></a> </div> </div> <sup>267</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bernard%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id385"><span class="name western">Loris Bernard</span></a><div hidden="hidden" id="id385"> <h3><span class="name western">Loris Bernard</span></h3> <div class="p"> <sup>184</sup>Cogentech Cancer Genetic Test Laboratory, Milan, Italy</div> <div class="p"> <sup>268</sup>Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bernard%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Loris Bernard</span></a> </div> </div> <sup>184,</sup><sup>268</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dolcetti%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id386"><span class="name western">Riccardo Dolcetti</span></a><div hidden="hidden" id="id386"> <h3><span class="name western">Riccardo Dolcetti</span></h3> <div class="p"> <sup>269</sup>Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dolcetti%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Riccardo Dolcetti</span></a> </div> </div> <sup>269</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Manoukian%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id387"><span class="name western">Siranoush Manoukian</span></a><div hidden="hidden" id="id387"> <h3><span class="name western">Siranoush Manoukian</span></h3> <div class="p"> <sup>183</sup>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Manoukian%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Siranoush Manoukian</span></a> </div> </div> <sup>183</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Arnold%20N%22%5BAuthor%5D" class="usa-link" aria-describedby="id388"><span class="name western">Norbert Arnold</span></a><div hidden="hidden" id="id388"> <h3><span class="name western">Norbert Arnold</span></h3> <div class="p"> <sup>270</sup>Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Arnold%20N%22%5BAuthor%5D" class="usa-link"><span class="name western">Norbert Arnold</span></a> </div> </div> <sup>270</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Engel%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id389"><span class="name western">Christoph Engel</span></a><div hidden="hidden" id="id389"> <h3><span class="name western">Christoph Engel</span></h3> <div class="p"> <sup>271</sup>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Engel%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Christoph Engel</span></a> </div> </div> <sup>271</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Deissler%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id390"><span class="name western">Helmut Deissler</span></a><div hidden="hidden" id="id390"> <h3><span class="name western">Helmut Deissler</span></h3> <div class="p"> <sup>272</sup>University Hospital Ulm, Ulm, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Deissler%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Helmut Deissler</span></a> </div> </div> <sup>272</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rhiem%20K%22%5BAuthor%5D" class="usa-link" aria-describedby="id391"><span class="name western">Kerstin Rhiem</span></a><div hidden="hidden" id="id391"> <h3><span class="name western">Kerstin Rhiem</span></h3> <div class="p"> <sup>202</sup>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</div> <div class="p"> <sup>203</sup>Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rhiem%20K%22%5BAuthor%5D" class="usa-link"><span class="name western">Kerstin Rhiem</span></a> </div> </div> <sup>202,</sup><sup>203</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Niederacher%20D%22%5BAuthor%5D" class="usa-link" aria-describedby="id392"><span class="name western">Dieter Niederacher</span></a><div hidden="hidden" id="id392"> <h3><span class="name western">Dieter Niederacher</span></h3> <div class="p"> <sup>273</sup>Department of Obstetrics and Gynecology, University Medical Center, Heinrich-Heine University, Düsseldorf, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Niederacher%20D%22%5BAuthor%5D" class="usa-link"><span class="name western">Dieter Niederacher</span></a> </div> </div> <sup>273</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Plendl%20H%22%5BAuthor%5D" class="usa-link" aria-describedby="id393"><span class="name western">Hansjoerg Plendl</span></a><div hidden="hidden" id="id393"> <h3><span class="name western">Hansjoerg Plendl</span></h3> <div class="p"> <sup>274</sup>Institute of Human Genetics, University Hospital of Schleswig-Holstein, University Kiel, Kiel, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Plendl%20H%22%5BAuthor%5D" class="usa-link"><span class="name western">Hansjoerg Plendl</span></a> </div> </div> <sup>274</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sutter%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id394"><span class="name western">Christian Sutter</span></a><div hidden="hidden" id="id394"> <h3><span class="name western">Christian Sutter</span></h3> <div class="p"> <sup>275</sup>Department of Human Genetics, University of Heidelberg, Heidelberg, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Sutter%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Christian Sutter</span></a> </div> </div> <sup>275</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wappenschmidt%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id395"><span class="name western">Barbara Wappenschmidt</span></a><div hidden="hidden" id="id395"> <h3><span class="name western">Barbara Wappenschmidt</span></h3> <div class="p"> <sup>202</sup>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</div> <div class="p"> <sup>203</sup>Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wappenschmidt%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Barbara Wappenschmidt</span></a> </div> </div> <sup>202,</sup><sup>203</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Borg%20%C3%85%22%5BAuthor%5D" class="usa-link" aria-describedby="id396"><span class="name western">Åke Borg</span></a><div hidden="hidden" id="id396"> <h3><span class="name western">Åke Borg</span></h3> <div class="p"> <sup>276</sup>Department of Oncology, Lund University, Lund, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Borg%20%C3%85%22%5BAuthor%5D" class="usa-link"><span class="name western">Åke Borg</span></a> </div> </div> <sup>276</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melin%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id397"><span class="name western">Beatrice Melin</span></a><div hidden="hidden" id="id397"> <h3><span class="name western">Beatrice Melin</span></h3> <div class="p"> <sup>277</sup>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Melin%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Beatrice Melin</span></a> </div> </div> <sup>277</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rantala%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id398"><span class="name western">Johanna Rantala</span></a><div hidden="hidden" id="id398"> <h3><span class="name western">Johanna Rantala</span></h3> <div class="p"> <sup>278</sup>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rantala%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Johanna Rantala</span></a> </div> </div> <sup>278</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Soller%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id399"><span class="name western">Maria Soller</span></a><div hidden="hidden" id="id399"> <h3><span class="name western">Maria Soller</span></h3> <div class="p"> <sup>279</sup>Department of Clinical Genetics, University and Regional Laboratories, Lund University Hospital, Lund, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Soller%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Maria Soller</span></a> </div> </div> <sup>279</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nathanson%20KL%22%5BAuthor%5D" class="usa-link" aria-describedby="id400"><span class="name western">Katherine L Nathanson</span></a><div hidden="hidden" id="id400"> <h3><span class="name western">Katherine L Nathanson</span></h3> <div class="p"> <sup>216</sup>Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</div> <div class="p"> <sup>280</sup>Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Nathanson%20KL%22%5BAuthor%5D" class="usa-link"><span class="name western">Katherine L Nathanson</span></a> </div> </div> <sup>216,</sup><sup>280</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Domchek%20SM%22%5BAuthor%5D" class="usa-link" aria-describedby="id401"><span class="name western">Susan M Domchek</span></a><div hidden="hidden" id="id401"> <h3><span class="name western">Susan M Domchek</span></h3> <div class="p"> <sup>216</sup>Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</div> <div class="p"> <sup>280</sup>Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Domchek%20SM%22%5BAuthor%5D" class="usa-link"><span class="name western">Susan M Domchek</span></a> </div> </div> <sup>216,</sup><sup>280</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rodriguez%20GC%22%5BAuthor%5D" class="usa-link" aria-describedby="id402"><span class="name western">Gustavo C Rodriguez</span></a><div hidden="hidden" id="id402"> <h3><span class="name western">Gustavo C Rodriguez</span></h3> <div class="p"> <sup>281</sup>Division of Gynecologic Oncology, North Shore University Health System, University of Chicago, Evanston, IL, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Rodriguez%20GC%22%5BAuthor%5D" class="usa-link"><span class="name western">Gustavo C Rodriguez</span></a> </div> </div> <sup>281</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Salani%20R%22%5BAuthor%5D" class="usa-link" aria-describedby="id403"><span class="name western">Ritu Salani</span></a><div hidden="hidden" id="id403"> <h3><span class="name western">Ritu Salani</span></h3> <div class="p"> <sup>282</sup>Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus, OH, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Salani%20R%22%5BAuthor%5D" class="usa-link"><span class="name western">Ritu Salani</span></a> </div> </div> <sup>282</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kaulich%20DG%22%5BAuthor%5D" class="usa-link" aria-describedby="id404"><span class="name western">Daphne Gschwantler Kaulich</span></a><div hidden="hidden" id="id404"> <h3><span class="name western">Daphne Gschwantler Kaulich</span></h3> <div class="p"> <sup>219</sup>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kaulich%20DG%22%5BAuthor%5D" class="usa-link"><span class="name western">Daphne Gschwantler Kaulich</span></a> </div> </div> <sup>219</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tea%20MK%22%5BAuthor%5D" class="usa-link" aria-describedby="id405"><span class="name western">Muy-Kheng Tea</span></a><div hidden="hidden" id="id405"> <h3><span class="name western">Muy-Kheng Tea</span></h3> <div class="p"> <sup>219</sup>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Tea%20MK%22%5BAuthor%5D" class="usa-link"><span class="name western">Muy-Kheng Tea</span></a> </div> </div> <sup>219</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paluch%20SS%22%5BAuthor%5D" class="usa-link" aria-describedby="id406"><span class="name western">Shani Shimon Paluch</span></a><div hidden="hidden" id="id406"> <h3><span class="name western">Shani Shimon Paluch</span></h3> <div class="p"> <sup>220</sup>The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</div> <div class="p"> <sup>221</sup>Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Paluch%20SS%22%5BAuthor%5D" class="usa-link"><span class="name western">Shani Shimon Paluch</span></a> </div> </div> <sup>220,</sup><sup>221</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laitman%20Y%22%5BAuthor%5D" class="usa-link" aria-describedby="id407"><span class="name western">Yael Laitman</span></a><div hidden="hidden" id="id407"> <h3><span class="name western">Yael Laitman</span></h3> <div class="p"> <sup>220</sup>The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</div> <div class="p"> <sup>221</sup>Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Laitman%20Y%22%5BAuthor%5D" class="usa-link"><span class="name western">Yael Laitman</span></a> </div> </div> <sup>220,</sup><sup>221</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Skytte%20AB%22%5BAuthor%5D" class="usa-link" aria-describedby="id408"><span class="name western">Anne-Bine Skytte</span></a><div hidden="hidden" id="id408"> <h3><span class="name western">Anne-Bine Skytte</span></h3> <div class="p"> <sup>283</sup>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Skytte%20AB%22%5BAuthor%5D" class="usa-link"><span class="name western">Anne-Bine Skytte</span></a> </div> </div> <sup>283</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kruse%20TA%22%5BAuthor%5D" class="usa-link" aria-describedby="id409"><span class="name western">Torben A Kruse</span></a><div hidden="hidden" id="id409"> <h3><span class="name western">Torben A Kruse</span></h3> <div class="p"> <sup>222</sup>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kruse%20TA%22%5BAuthor%5D" class="usa-link"><span class="name western">Torben A Kruse</span></a> </div> </div> <sup>222</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jensen%20UB%22%5BAuthor%5D" class="usa-link" aria-describedby="id410"><span class="name western">Uffe Birk Jensen</span></a><div hidden="hidden" id="id410"> <h3><span class="name western">Uffe Birk Jensen</span></h3> <div class="p"> <sup>284</sup>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Jensen%20UB%22%5BAuthor%5D" class="usa-link"><span class="name western">Uffe Birk Jensen</span></a> </div> </div> <sup>284</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Robson%20M%22%5BAuthor%5D" class="usa-link" aria-describedby="id411"><span class="name western">Mark Robson</span></a><div hidden="hidden" id="id411"> <h3><span class="name western">Mark Robson</span></h3> <div class="p"> <sup>223</sup>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Robson%20M%22%5BAuthor%5D" class="usa-link"><span class="name western">Mark Robson</span></a> </div> </div> <sup>223</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gerdes%20AM%22%5BAuthor%5D" class="usa-link" aria-describedby="id412"><span class="name western">Anne-Marie Gerdes</span></a><div hidden="hidden" id="id412"> <h3><span class="name western">Anne-Marie Gerdes</span></h3> <div class="p"> <sup>285</sup>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gerdes%20AM%22%5BAuthor%5D" class="usa-link"><span class="name western">Anne-Marie Gerdes</span></a> </div> </div> <sup>285</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ejlertsen%20B%22%5BAuthor%5D" class="usa-link" aria-describedby="id413"><span class="name western">Bent Ejlertsen</span></a><div hidden="hidden" id="id413"> <h3><span class="name western">Bent Ejlertsen</span></h3> <div class="p"> <sup>286</sup>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ejlertsen%20B%22%5BAuthor%5D" class="usa-link"><span class="name western">Bent Ejlertsen</span></a> </div> </div> <sup>286</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Foretova%20L%22%5BAuthor%5D" class="usa-link" aria-describedby="id414"><span class="name western">Lenka Foretova</span></a><div hidden="hidden" id="id414"> <h3><span class="name western">Lenka Foretova</span></h3> <div class="p"> <sup>287</sup>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Foretova%20L%22%5BAuthor%5D" class="usa-link"><span class="name western">Lenka Foretova</span></a> </div> </div> <sup>287</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Savage%20SA%22%5BAuthor%5D" class="usa-link" aria-describedby="id415"><span class="name western">Sharon A Savage</span></a><div hidden="hidden" id="id415"> <h3><span class="name western">Sharon A Savage</span></h3> <div class="p"> <sup>11</sup>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Savage%20SA%22%5BAuthor%5D" class="usa-link"><span class="name western">Sharon A Savage</span></a> </div> </div> <sup>11</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lester%20J%22%5BAuthor%5D" class="usa-link" aria-describedby="id416"><span class="name western">Jenny Lester</span></a><div hidden="hidden" id="id416"> <h3><span class="name western">Jenny Lester</span></h3> <div class="p"> <sup>101</sup>Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lester%20J%22%5BAuthor%5D" class="usa-link"><span class="name western">Jenny Lester</span></a> </div> </div> <sup>101</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Soucy%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id417"><span class="name western">Penny Soucy</span></a><div hidden="hidden" id="id417"> <h3><span class="name western">Penny Soucy</span></h3> <div class="p"> <sup>55</sup>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Soucy%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Penny Soucy</span></a> </div> </div> <sup>55</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kuchenbaecker%20KB%22%5BAuthor%5D" class="usa-link" aria-describedby="id418"><span class="name western">Karoline B Kuchenbaecker</span></a><div hidden="hidden" id="id418"> <h3><span class="name western">Karoline B Kuchenbaecker</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Kuchenbaecker%20KB%22%5BAuthor%5D" class="usa-link"><span class="name western">Karoline B Kuchenbaecker</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olswold%20C%22%5BAuthor%5D" class="usa-link" aria-describedby="id419"><span class="name western">Curtis Olswold</span></a><div hidden="hidden" id="id419"> <h3><span class="name western">Curtis Olswold</span></h3> <div class="p"> <sup>112</sup>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Olswold%20C%22%5BAuthor%5D" class="usa-link"><span class="name western">Curtis Olswold</span></a> </div> </div> <sup>112</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cunningham%20JM%22%5BAuthor%5D" class="usa-link" aria-describedby="id420"><span class="name western">Julie M Cunningham</span></a><div hidden="hidden" id="id420"> <h3><span class="name western">Julie M Cunningham</span></h3> <div class="p"> <sup>39</sup>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Cunningham%20JM%22%5BAuthor%5D" class="usa-link"><span class="name western">Julie M Cunningham</span></a> </div> </div> <sup>39</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Slager%20S%22%5BAuthor%5D" class="usa-link" aria-describedby="id421"><span class="name western">Susan Slager</span></a><div hidden="hidden" id="id421"> <h3><span class="name western">Susan Slager</span></h3> <div class="p"> <sup>112</sup>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Slager%20S%22%5BAuthor%5D" class="usa-link"><span class="name western">Susan Slager</span></a> </div> </div> <sup>112</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pankratz%20VS%22%5BAuthor%5D" class="usa-link" aria-describedby="id422"><span class="name western">Vernon S Pankratz</span></a><div hidden="hidden" id="id422"> <h3><span class="name western">Vernon S Pankratz</span></h3> <div class="p"> <sup>112</sup>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pankratz%20VS%22%5BAuthor%5D" class="usa-link"><span class="name western">Vernon S Pankratz</span></a> </div> </div> <sup>112</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dicks%20E%22%5BAuthor%5D" class="usa-link" aria-describedby="id423"><span class="name western">Ed Dicks</span></a><div hidden="hidden" id="id423"> <h3><span class="name western">Ed Dicks</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dicks%20E%22%5BAuthor%5D" class="usa-link"><span class="name western">Ed Dicks</span></a> </div> </div> <sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lakhani%20SR%22%5BAuthor%5D" class="usa-link" aria-describedby="id424"><span class="name western">Sunil R Lakhani</span></a><div hidden="hidden" id="id424"> <h3><span class="name western">Sunil R Lakhani</span></h3> <div class="p"> <sup>10</sup>University of Queensland, UQ Centre for Clinical Research (UQCCR) Royal Brisbane and Women's Hospital, Herston, QLD, Australia</div> <div class="p"> <sup>288</sup>The UQ Centre for Clinical Research, The University of Queensland, The Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Lakhani%20SR%22%5BAuthor%5D" class="usa-link"><span class="name western">Sunil R Lakhani</span></a> </div> </div> <sup>10,</sup><sup>288</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Couch%20FJ%22%5BAuthor%5D" class="usa-link" aria-describedby="id425"><span class="name western">Fergus J Couch</span></a><div hidden="hidden" id="id425"> <h3><span class="name western">Fergus J Couch</span></h3> <div class="p"> <sup>39</sup>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA</div> <div class="p"> <sup>112</sup>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Couch%20FJ%22%5BAuthor%5D" class="usa-link"><span class="name western">Fergus J Couch</span></a> </div> </div> <sup>39,</sup><sup>112</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hall%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id426"><span class="name western">Per Hall</span></a><div hidden="hidden" id="id426"> <h3><span class="name western">Per Hall</span></h3> <div class="p"> <sup>24</sup>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hall%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Per Hall</span></a> </div> </div> <sup>24</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Monteiro%20ANA%22%5BAuthor%5D" class="usa-link" aria-describedby="id427"><span class="name western">Alvaro N A Monteiro</span></a><div hidden="hidden" id="id427"> <h3><span class="name western">Alvaro N A Monteiro</span></h3> <div class="p"> <sup>12</sup>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Monteiro%20ANA%22%5BAuthor%5D" class="usa-link"><span class="name western">Alvaro N A Monteiro</span></a> </div> </div> <sup>12</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gayther%20SA%22%5BAuthor%5D" class="usa-link" aria-describedby="id428"><span class="name western">Simon A Gayther</span></a><div hidden="hidden" id="id428"> <h3><span class="name western">Simon A Gayther</span></h3> <div class="p"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Gayther%20SA%22%5BAuthor%5D" class="usa-link"><span class="name western">Simon A Gayther</span></a> </div> </div> <sup>9</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pharoah%20PDP%22%5BAuthor%5D" class="usa-link" aria-describedby="id429"><span class="name western">Paul D P Pharoah</span></a><div hidden="hidden" id="id429"> <h3><span class="name western">Paul D P Pharoah</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pharoah%20PDP%22%5BAuthor%5D" class="usa-link"><span class="name western">Paul D P Pharoah</span></a> </div> </div> <sup>5</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reddel%20RR%22%5BAuthor%5D" class="usa-link" aria-describedby="id430"><span class="name western">Roger R Reddel</span></a><div hidden="hidden" id="id430"> <h3><span class="name western">Roger R Reddel</span></h3> <div class="p"> <sup>7</sup>Cancer Research Unit, Children's Medical Research Institute, Westmead, NSW, Australia</div> <div class="p"> <sup>8</sup>Sydney Medical School, University of Sydney, Sydney, NSW, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Reddel%20RR%22%5BAuthor%5D" class="usa-link"><span class="name western">Roger R Reddel</span></a> </div> </div> <sup>7,</sup><sup>8</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goode%20EL%22%5BAuthor%5D" class="usa-link" aria-describedby="id431"><span class="name western">Ellen L Goode</span></a><div hidden="hidden" id="id431"> <h3><span class="name western">Ellen L Goode</span></h3> <div class="p"> <sup>26</sup>Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Goode%20EL%22%5BAuthor%5D" class="usa-link"><span class="name western">Ellen L Goode</span></a> </div> </div> <sup>26</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Greene%20MH%22%5BAuthor%5D" class="usa-link" aria-describedby="id432"><span class="name western">Mark H Greene</span></a><div hidden="hidden" id="id432"> <h3><span class="name western">Mark H Greene</span></h3> <div class="p"> <sup>11</sup>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Greene%20MH%22%5BAuthor%5D" class="usa-link"><span class="name western">Mark H Greene</span></a> </div> </div> <sup>11</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Easton%20DF%22%5BAuthor%5D" class="usa-link" aria-describedby="id433"><span class="name western">Douglas F Easton</span></a><div hidden="hidden" id="id433"> <h3><span class="name western">Douglas F Easton</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Easton%20DF%22%5BAuthor%5D" class="usa-link"><span class="name western">Douglas F Easton</span></a> </div> </div> <sup>3,</sup><sup>5,</sup><sup>$</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Berchuck%20A%22%5BAuthor%5D" class="usa-link" aria-describedby="id434"><span class="name western">Andrew Berchuck</span></a><div hidden="hidden" id="id434"> <h3><span class="name western">Andrew Berchuck</span></h3> <div class="p"> <sup>289</sup>Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Berchuck%20A%22%5BAuthor%5D" class="usa-link"><span class="name western">Andrew Berchuck</span></a> </div> </div> <sup>289,</sup><sup>$</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Antoniou%20AC%22%5BAuthor%5D" class="usa-link" aria-describedby="id435"><span class="name western">Antonis C Antoniou</span></a><div hidden="hidden" id="id435"> <h3><span class="name western">Antonis C Antoniou</span></h3> <div class="p"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Antoniou%20AC%22%5BAuthor%5D" class="usa-link"><span class="name western">Antonis C Antoniou</span></a> </div> </div> <sup>3,</sup><sup>$</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chenevix-Trench%20G%22%5BAuthor%5D" class="usa-link" aria-describedby="id436"><span class="name western">Georgia Chenevix-Trench</span></a><div hidden="hidden" id="id436"> <h3><span class="name western">Georgia Chenevix-Trench</span></h3> <div class="p"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Chenevix-Trench%20G%22%5BAuthor%5D" class="usa-link"><span class="name western">Georgia Chenevix-Trench</span></a> </div> </div> <sup>4,</sup><sup>$</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dunning%20AM%22%5BAuthor%5D" class="usa-link" aria-describedby="id437"><span class="name western">Alison M Dunning</span></a><div hidden="hidden" id="id437"> <h3><span class="name western">Alison M Dunning</span></h3> <div class="p"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Dunning%20AM%22%5BAuthor%5D" class="usa-link"><span class="name western">Alison M Dunning</span></a> </div> </div> <sup>5,</sup><sup>$</sup> </div> <ul class="d-buttons inline-list"> <li><button class="d-button" aria-controls="aip_a" aria-expanded="false">Author information</button></li> <li><button class="d-button" aria-controls="clp_a" aria-expanded="false">Copyright and License information</button></li> </ul> <div class="d-panels font-secondary-light"> <div id="aip_a" class="d-panel p" style="display: none"> <div class="p" id="A1"> <sup>1</sup>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div id="A2"> <sup>2</sup>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div id="A3"> <sup>3</sup>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK</div> <div id="A4"> <sup>4</sup>Department of Genetics, Queensland Institute of Medical Research, Brisbane, Australia</div> <div id="A5"> <sup>5</sup>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK</div> <div id="A6"> <sup>6</sup>School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia</div> <div id="A7"> <sup>7</sup>Cancer Research Unit, Children's Medical Research Institute, Westmead, NSW, Australia</div> <div id="A8"> <sup>8</sup>Sydney Medical School, University of Sydney, Sydney, NSW, Australia</div> <div id="A9"> <sup>9</sup>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA</div> <div id="A10"> <sup>10</sup>University of Queensland, UQ Centre for Clinical Research (UQCCR) Royal Brisbane and Women's Hospital, Herston, QLD, Australia</div> <div id="A11"> <sup>11</sup>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA</div> <div id="A12"> <sup>12</sup>Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA</div> <div id="A13"> <sup>13</sup>McGill University, Montréal, QC, Canada</div> <div id="A14"> <sup>14</sup>Génome Québec Innovation Centre, Montréal, QC, Canada</div> <div id="A15"> <sup>15</sup>Australian Cancer Study, Australian Ovarian Cancer Study Group, kConFab, GENICA, SWE-BRCA, HEBON, EMBRACE, GEMO Study Collaborators. Full membership lists are provided in the Supplementary Note</div> <div id="A16"> <sup>16</sup>Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium</div> <div id="A17"> <sup>17</sup>Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium</div> <div id="A18"> <sup>18</sup>Department of Epidemiology and Public Health, Yale University School of Public Health and School of Medicine, New Haven, CT, USA</div> <div id="A19"> <sup>19</sup>Human Genotyping-CEGEN Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div id="A20"> <sup>20</sup>Department of Epidemiology, University of Washington, Seattle, WA, USA</div> <div id="A21"> <sup>21</sup>Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA</div> <div id="A22"> <sup>22</sup>Section of Biostatistics and Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, NH, USA</div> <div id="A23"> <sup>23</sup>Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA</div> <div id="A24"> <sup>24</sup>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</div> <div id="A25"> <sup>25</sup>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div id="A26"> <sup>26</sup>Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, USA</div> <div id="A27"> <sup>27</sup>Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK</div> <div id="A28"> <sup>28</sup>Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA</div> <div id="A29"> <sup>29</sup>Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div id="A30"> <sup>30</sup>Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div id="A31"> <sup>31</sup>Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA</div> <div id="A32"> <sup>32</sup>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div id="A33"> <sup>33</sup>David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA</div> <div id="A34"> <sup>34</sup>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Belgium</div> <div id="A35"> <sup>35</sup>Vesalius Research Center (VRC), VIB, Leuven, Belgium</div> <div id="A36"> <sup>36</sup>INSERM U1018, CESP (Center for Research in Epidemiology and Population Health), Environmental Epidemiology of Cancer, Villejuif, France</div> <div id="A37"> <sup>37</sup>University Paris-Sud, UMRS 1018, Villejuif, France</div> <div id="A38"> <sup>38</sup>Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div id="A39"> <sup>39</sup>Department of Laboratory Medicine and Pathology, Division of Experimental Pathology, Mayo Clinic, Rochester, MN, USA</div> <div id="A40"> <sup>40</sup>CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, UK</div> <div id="A41"> <sup>41</sup>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</div> <div id="A42"> <sup>42</sup>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div id="A43"> <sup>43</sup>National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany</div> <div id="A44"> <sup>44</sup>PMV Research Group at the Department of Child and Adolescent Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany</div> <div id="A45"> <sup>45</sup>Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's & St. Thomas' NHS Foundation Trust in partnership with King's College London, London, UK</div> <div id="A46"> <sup>46</sup>Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany</div> <div id="A47"> <sup>47</sup>Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</div> <div id="A48"> <sup>48</sup>Ontario Cancer Genetics Network, Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</div> <div id="A49"> <sup>49</sup>Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA</div> <div id="A50"> <sup>50</sup>Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, VIC, Australia</div> <div id="A51"> <sup>51</sup>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</div> <div id="A52"> <sup>52</sup>Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia</div> <div id="A53"> <sup>53</sup>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia</div> <div id="A54"> <sup>54</sup>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany</div> <div id="A55"> <sup>55</sup>Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada</div> <div id="A56"> <sup>56</sup>Cancer Epidemiology Program, University of Hawaii Cancer Center, HI, USA</div> <div id="A57"> <sup>57</sup>University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany</div> <div id="A58"> <sup>58</sup>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</div> <div id="A59"> <sup>59</sup>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy</div> <div id="A60"> <sup>60</sup>Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, UK</div> <div id="A61"> <sup>61</sup>Division of Breast Cancer Research, The Institute of Cancer Research, Sutton, Surrey, UK</div> <div id="A62"> <sup>62</sup>Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA</div> <div id="A63"> <sup>63</sup>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</div> <div id="A64"> <sup>64</sup>University of Tübingen, Germany</div> <div id="A65"> <sup>65</sup>Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, London, UK</div> <div id="A66"> <sup>66</sup>Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</div> <div id="A67"> <sup>67</sup>Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics, University of Oulu, Oulu University Hospital, Oulu, Finland</div> <div id="A68"> <sup>68</sup>Biocenter Oulu, University of Oulu, Oulu, Finland</div> <div id="A69"> <sup>69</sup>Department of Gynecology, Jena University Hospital, Jena, Germany</div> <div id="A70"> <sup>70</sup>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</div> <div id="A71"> <sup>71</sup>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</div> <div id="A72"> <sup>72</sup>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</div> <div id="A73"> <sup>73</sup>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</div> <div id="A74"> <sup>74</sup>School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine, Biocenter Kuopio, Cancer Center of Eastern Finland, University of Eastern Finland, Kuopio, Finland</div> <div id="A75"> <sup>75</sup>Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland</div> <div id="A76"> <sup>76</sup>Department of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany</div> <div id="A77"> <sup>77</sup>Department of Radiation Oncology, Hannover Medical School, Hannover, Germany</div> <div id="A78"> <sup>78</sup>Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA</div> <div id="A79"> <sup>79</sup>Department of Epidemiology, University of California Irvine, Irvine, CA, USA</div> <div id="A80"> <sup>80</sup>Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA</div> <div id="A81"> <sup>81</sup>Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Oslo, Norway</div> <div id="A82"> <sup>82</sup>Faculty of Medicine (Faculty Division Ahus), UiO, Norway</div> <div id="A83"> <sup>83</sup>The University of Texas School of Public Health, Houston, TX, USA</div> <div id="A84"> <sup>84</sup>Warwick Medical School, Warwick University, Coventry, UK</div> <div id="A85"> <sup>85</sup>Institute of Population Health, University of Manchester, Manchester, UK</div> <div id="A86"> <sup>86</sup>Maggee Women's Hospital, Pittsburg, PA, USA</div> <div id="A87"> <sup>87</sup>Department of Gynecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany</div> <div id="A88"> <sup>88</sup>Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Klinik Wiesbaden, Wiesbaden, Germany</div> <div id="A89"> <sup>89</sup>Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany</div> <div id="A90"> <sup>90</sup>Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan</div> <div id="A91"> <sup>91</sup>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia</div> <div id="A92"> <sup>92</sup>Breast Cancer Research Unit, University Malaya Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia</div> <div id="A93"> <sup>93</sup>Institut für Humangenetik Wiesbaden, Wiesbaden, Germany</div> <div id="A94"> <sup>94</sup>International Epidemiology Institute, Rockville, MD, USA</div> <div id="A95"> <sup>95</sup>Seoul National University College of Medicine, Seoul, Korea</div> <div id="A96"> <sup>96</sup>Department of Gynecologic Oncology, Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan</div> <div id="A97"> <sup>97</sup>Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore</div> <div id="A98"> <sup>98</sup>Saw Swee Hock School of Public Health, National University of Singapore</div> <div id="A99"> <sup>99</sup>Department of Pathology and Molecular Diagnostic, Aichi Cancer Center Central Hospital, Nagoya, Aichi, Japan</div> <div id="A100"> <sup>100</sup>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</div> <div id="A101"> <sup>101</sup>Women's Cancer Program, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA</div> <div id="A102"> <sup>102</sup>National Cancer Institute, Bangkok, Thailand</div> <div id="A103"> <sup>103</sup>Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark</div> <div id="A104"> <sup>104</sup>The Juliane Marie Centre, Department of Obstetrics and Gynecology, Rigshospitalet, Copenhagen, Denmark</div> <div id="A105"> <sup>105</sup>International Agency for Research on Cancer, Lyon, France</div> <div id="A106"> <sup>106</sup>Faculty of Medicine, University of Southampton, University Hospital Southampton, Southampton, UK</div> <div id="A107"> <sup>107</sup>Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark</div> <div id="A108"> <sup>108</sup>Colleague of Public Health, China Medical University, Taichong, Taiwan</div> <div id="A109"> <sup>109</sup>Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan</div> <div id="A110"> <sup>110</sup>Department of Obstetrics and Gynaecology, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia</div> <div id="A111"> <sup>111</sup>Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Copenhagen, Denmark</div> <div id="A112"> <sup>112</sup>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA</div> <div id="A113"> <sup>113</sup>Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div id="A114"> <sup>114</sup>Department of Community and Family Medicine, Duke University Medical Center, Durham, NC, USA</div> <div id="A115"> <sup>115</sup>Department of Cancer Epidemiology/Clinical Cancer Registry, University Clinic Hamburg-Eppendorf, Hamburg, Germany</div> <div id="A116"> <sup>116</sup>Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany</div> <div id="A117"> <sup>117</sup>Department of Statistical Science, Duke University, Durham, NC, USA</div> <div id="A118"> <sup>118</sup>Cancer Prevention, Detection and Control Research Program, Duke Cancer Institute, Durham, NC, USA</div> <div id="A119"> <sup>119</sup>Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA</div> <div id="A120"> <sup>120</sup>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA</div> <div id="A121"> <sup>121</sup>Sanquin Research, Amsterdam, The Netherlands</div> <div id="A122"> <sup>122</sup>Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA</div> <div id="A123"> <sup>123</sup>Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands</div> <div id="A124"> <sup>124</sup>Human Genetics Division, Genome Institute of Singapore, Singapore</div> <div id="A125"> <sup>125</sup>The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, NJ, USA</div> <div id="A126"> <sup>126</sup>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div id="A127"> <sup>127</sup>Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</div> <div id="A128"> <sup>128</sup>Department of Clinical Genetics, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland</div> <div id="A129"> <sup>129</sup>Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway</div> <div id="A130"> <sup>130</sup>Department of Clinical Medicine, University of Bergen, Bergen, Norway</div> <div id="A131"> <sup>131</sup>Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium</div> <div id="A132"> <sup>132</sup>Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium</div> <div id="A133"> <sup>133</sup>Department of General Medical Oncology, University Hospitals Leuven, Belgium</div> <div id="A134"> <sup>134</sup>Comprehensive Cancer Center The Netherlands, Utrecht, The Netherlands</div> <div id="A135"> <sup>135</sup>Department of Epidemiology, Biostatistics and HTA, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div id="A136"> <sup>136</sup>Department of Urology, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div id="A137"> <sup>137</sup>Université Paris Sorbonne Cité, UMR-S775 Inserm, Paris, France</div> <div id="A138"> <sup>138</sup>Department of Gynecology, Radboud University Medical Centre, Nijmegen, Netherlands</div> <div id="A139"> <sup>139</sup>Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain</div> <div id="A140"> <sup>140</sup>Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain</div> <div id="A141"> <sup>141</sup>Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA</div> <div id="A142"> <sup>142</sup>Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA</div> <div id="A143"> <sup>143</sup>Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain</div> <div id="A144"> <sup>144</sup>Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR, USA</div> <div id="A145"> <sup>145</sup>Servicio de Oncología Médica, Hospital Universitario La Paz, Madrid, Spain</div> <div id="A146"> <sup>146</sup>Division of Epidemiology and Biostatistics, University of New Mexico, Albuquerque, NM, USA</div> <div id="A147"> <sup>147</sup>Department of Population Health Research, Alberta Health Services-Cancer Care, Calgary, Alberta, Canada</div> <div id="A148"> <sup>148</sup>Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada</div> <div id="A149"> <sup>149</sup>Department of Oncology, University of Calgary, Calgary, Alberta, Canada</div> <div id="A150"> <sup>150</sup>Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada</div> <div id="A151"> <sup>151</sup>Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada</div> <div id="A152"> <sup>152</sup>Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada</div> <div id="A153"> <sup>153</sup>Welcome Trust Centre for Human Genetics, University of Oxford, UK</div> <div id="A154"> <sup>154</sup>Oxford Biomedical Research Centre, University of Oxford, UK</div> <div id="A155"> <sup>155</sup>School of medicine, National University of Ireland Galway, Ireland</div> <div id="A156"> <sup>156</sup>International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical Academy, Szczecin, Poland</div> <div id="A157"> <sup>157</sup>Department of Surgical Gynecology and Gynecological Oncology of Adults and Adolescents, Pomeranian Medical University, Szczecin, Poland</div> <div id="A158"> <sup>158</sup>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA</div> <div id="A159"> <sup>159</sup>Epidemiology Program, Cancer Research Center, University of Hawaii, Honolulu, HI, USA</div> <div id="A160"> <sup>160</sup>Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada</div> <div id="A161"> <sup>161</sup>Laboratory Medicine Program, University Health Network, Toronto, ON, Canada</div> <div id="A162"> <sup>162</sup>Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</div> <div id="A163"> <sup>163</sup>Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Denmark</div> <div id="A164"> <sup>164</sup>Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada</div> <div id="A165"> <sup>165</sup>Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada</div> <div id="A166"> <sup>166</sup>Gynecological Oncology Unit, The Royal Marsden Hospital, London, UK</div> <div id="A167"> <sup>167</sup>Genetic Epidemiology Department, Department of Pathology, The University of Melbourne, Melbourne, Australia</div> <div id="A168"> <sup>168</sup>Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div id="A169"> <sup>169</sup>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div id="A170"> <sup>170</sup>Department of Surgery and Cancer, Imperial College London, London, UK</div> <div id="A171"> <sup>171</sup>The Beatson West of Scotland Cancer Centre, Glasgow, UK</div> <div id="A172"> <sup>172</sup>Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden</div> <div id="A173"> <sup>173</sup>Department of Gynecological Oncology, Glasgow Royal Infirmary, Glasgow, UK</div> <div id="A174"> <sup>174</sup>Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA</div> <div id="A175"> <sup>175</sup>Saarland Cancer Registry, Saarbrücken, Germany</div> <div id="A176"> <sup>176</sup>Département de médecine sociale et préventive, Département de santé environnementale et santé au travail, Université de Montréal, Montreal, Quebec, Canada</div> <div id="A177"> <sup>177</sup>Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China</div> <div id="A178"> <sup>178</sup>Department of Medicine, McGill University, Montreal, Quebec, Canada</div> <div id="A179"> <sup>179</sup>Division of Clinical Epidemiology, McGill University Health Centre, Royal Victoria Hospital, Montreal, Quebec, Canada</div> <div id="A180"> <sup>180</sup>Dalla Lana School of Public Health, Faculty of Medicine, University of Toronto, Canada</div> <div id="A181"> <sup>181</sup>Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany</div> <div id="A182"> <sup>182</sup>Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany</div> <div id="A183"> <sup>183</sup>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy</div> <div id="A184"> <sup>184</sup>Cogentech Cancer Genetic Test Laboratory, Milan, Italy</div> <div id="A185"> <sup>185</sup>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy</div> <div id="A186"> <sup>186</sup>Department of Epidemiology, Center for Cancer Genetics Research and Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA</div> <div id="A187"> <sup>187</sup>Gynaecological Cancer Research Centre, UCL EGA Institute for Women's Health, London, UK</div> <div id="A188"> <sup>188</sup>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum, Bochum, Germany</div> <div id="A189"> <sup>189</sup>Department of Internal Medicine, Evangelische Kliniken Bonn GmbH, Johanniter Krankenhaus, Bonn, Germany</div> <div id="A190"> <sup>190</sup>Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center & Institute of Oncology, Warsaw, Poland</div> <div id="A191"> <sup>191</sup>Department of Molecular Pathology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</div> <div id="A192"> <sup>192</sup>Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland</div> <div id="A193"> <sup>193</sup>Department of Gynecologic Oncology, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland</div> <div id="A194"> <sup>194</sup>Department of Pathology, Oulu University Hospital, University of Oulu, Oulu, Finland</div> <div id="A195"> <sup>195</sup>Family Cancer Clinic, Department of Medical Oncology, Erasmus MC, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands</div> <div id="A196"> <sup>196</sup>Department of Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands</div> <div id="A197"> <sup>197</sup>Postgraduate School of Molecular Medicine, Warsaw Medical University, Warsaw, Poland</div> <div id="A198"> <sup>198</sup>N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus</div> <div id="A199"> <sup>199</sup>Ministry of Public Health, Thailand</div> <div id="A200"> <sup>200</sup>Department of Gynecology and Obstetrics, Ludwig-Maximilians-Universität, Munich, Germany</div> <div id="A201"> <sup>201</sup>Insitute of Human Genetics, Technische Universität, Munich, Germany</div> <div id="A202"> <sup>202</sup>Centre of Familial Breast and Ovarian Cancer, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, Germany</div> <div id="A203"> <sup>203</sup>Centre for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany</div> <div id="A204"> <sup>204</sup>Department of Breast Oncology, Aichi Cancer Center Hospital, Nagoya, Japan</div> <div id="A205"> <sup>205</sup>Singapore Eye Research Institute, National University of Singapore, Singapore</div> <div id="A206"> <sup>206</sup>Shanghai Center for Disease Control and Prevention, Shanghai, China</div> <div id="A207"> <sup>207</sup>Division of Oncology, Wexner Medical Center, The Ohio State University, Columbus, OH, USA</div> <div id="A208"> <sup>208</sup>Roswell Park Cancer Institute, Buffalo, NY, USA</div> <div id="A209"> <sup>209</sup>Department of Medical Oncology, Papageorgiou Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Macedonia, Greece</div> <div id="A210"> <sup>210</sup>Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan</div> <div id="A211"> <sup>211</sup>Cancer Center, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</div> <div id="A212"> <sup>212</sup>Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung, Taiwan</div> <div id="A213"> <sup>213</sup>Institut Curie, Department of Tumour Biology, Paris, France</div> <div id="A214"> <sup>214</sup>Institut Curie, INSERM U830, Paris, France</div> <div id="A215"> <sup>215</sup>Université Paris Descartes, Sorbonne Paris Cité, France</div> <div id="A216"> <sup>216</sup>Basser Research Centre, Abramson Cancer Center, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</div> <div id="A217"> <sup>217</sup>Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA</div> <div id="A218"> <sup>218</sup>Gynecologic Oncology Group Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY, USA</div> <div id="A219"> <sup>219</sup>Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria</div> <div id="A220"> <sup>220</sup>The Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, Israel</div> <div id="A221"> <sup>221</sup>Institute of Oncology, Sheba Medical Center, Tel-Hashomer, Israel</div> <div id="A222"> <sup>222</sup>Department of Clinical Genetics, Odense University Hospital, Odense, Denmark</div> <div id="A223"> <sup>223</sup>Clinical Genetics Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA</div> <div id="A224"> <sup>224</sup>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</div> <div id="A225"> <sup>225</sup>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, USA</div> <div id="A226"> <sup>226</sup>Center for Translational Cancer Research, Department of Biological Sciences, University of Delaware, Newark, DE, USA</div> <div id="A227"> <sup>227</sup>Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain</div> <div id="A228"> <sup>228</sup>Dana-Farber Cancer Institute, Boston, MA, USA</div> <div id="A229"> <sup>229</sup>Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada</div> <div id="A230"> <sup>230</sup>Clinical Cancer Genetics, City of Hope, Duarte, CA, USA</div> <div id="A231"> <sup>231</sup>Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS, Padua, Italy</div> <div id="A232"> <sup>232</sup>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary</div> <div id="A233"> <sup>233</sup>Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA</div> <div id="A234"> <sup>234</sup>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research Demokritos, Aghia Paraskevi Attikis, Athens, Greece</div> <div id="A235"> <sup>235</sup>Department of Dermatology, University of Utah School of Medicine, Salt Lake City, UT, USA</div> <div id="A236"> <sup>236</sup>Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, USA</div> <div id="A237"> <sup>237</sup>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, Madrid, Spain</div> <div id="A238"> <sup>238</sup>N.N. Petrov Institute of Oncology, St.-Petersburg, Russia</div> <div id="A239"> <sup>239</sup>Latvian Biomedical Research and Study Centre, Riga, Latvia</div> <div id="A240"> <sup>240</sup>Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA</div> <div id="A241"> <sup>241</sup>Clinical Cancer Genetics, University of Texas MD Anderson Cancer Center, Houston, TX, USA</div> <div id="A242"> <sup>242</sup>VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Australia</div> <div id="A243"> <sup>243</sup>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</div> <div id="A244"> <sup>244</sup>Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands</div> <div id="A245"> <sup>245</sup>Department of Clinical Genetics, Maastricht University Medical Canter, Maastricht, The Netherlands</div> <div id="A246"> <sup>246</sup>Department of Clinical Genetics, VU University Medical Centre, Amsterdam, The Netherlands</div> <div id="A247"> <sup>247</sup>Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div id="A248"> <sup>248</sup>University of Groningen, University Medical Center, Department of Genetics, Groningen, The Netherlands</div> <div id="A249"> <sup>249</sup>Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands</div> <div id="A250"> <sup>250</sup>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands</div> <div id="A251"> <sup>251</sup>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands</div> <div id="A252"> <sup>252</sup>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK</div> <div id="A253"> <sup>253</sup>Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, UK</div> <div id="A254"> <sup>254</sup>Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK</div> <div id="A255"> <sup>255</sup>Academic Unit of Clinical and Molecular Oncology, Trinity College Dublin and St James's Hospital, Dublin, Eire</div> <div id="A256"> <sup>256</sup>Laboratory Medicine at Southern General Hospital, Glasgow, UK</div> <div id="A257"> <sup>257</sup>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK</div> <div id="A258"> <sup>258</sup>INSERM U946, Fondation Jean Dausset, Paris, France</div> <div id="A259"> <sup>259</sup>Service de Génétique, Institut de Cancérologie Gustave Roussy, Villejuif, France</div> <div id="A260"> <sup>260</sup>INSERM U1052, CNRS UMR5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Lyon, France</div> <div id="A261"> <sup>261</sup>Centre de Génétique, CHU Dijon, Université de Bourgogne, Dijon, France, and Centre Georges François Leclerc, Dijon, France</div> <div id="A262"> <sup>262</sup>Centre Antoine Lacassagne, Nice, France</div> <div id="A263"> <sup>263</sup>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon, Centre Léon Bérard, Lyon, France</div> <div id="A264"> <sup>264</sup>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France</div> <div id="A265"> <sup>265</sup>Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France</div> <div id="A266"> <sup>266</sup>Université Lyon 1, CNRS UMR5558, Lyon, France</div> <div id="A267"> <sup>267</sup>Department of Molecular Medicine, Sapienza University, Rome, Italy</div> <div id="A268"> <sup>268</sup>Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy</div> <div id="A269"> <sup>269</sup>Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy</div> <div id="A270"> <sup>270</sup>Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein/University Kiel, Kiel, Germany</div> <div id="A271"> <sup>271</sup>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany</div> <div id="A272"> <sup>272</sup>University Hospital Ulm, Ulm, Germany</div> <div id="A273"> <sup>273</sup>Department of Obstetrics and Gynecology, University Medical Center, Heinrich-Heine University, Düsseldorf, Germany</div> <div id="A274"> <sup>274</sup>Institute of Human Genetics, University Hospital of Schleswig-Holstein, University Kiel, Kiel, Germany</div> <div id="A275"> <sup>275</sup>Department of Human Genetics, University of Heidelberg, Heidelberg, Germany</div> <div id="A276"> <sup>276</sup>Department of Oncology, Lund University, Lund, Sweden</div> <div id="A277"> <sup>277</sup>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden</div> <div id="A278"> <sup>278</sup>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden</div> <div id="A279"> <sup>279</sup>Department of Clinical Genetics, University and Regional Laboratories, Lund University Hospital, Lund, Sweden</div> <div id="A280"> <sup>280</sup>Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</div> <div id="A281"> <sup>281</sup>Division of Gynecologic Oncology, North Shore University Health System, University of Chicago, Evanston, IL, USA</div> <div id="A282"> <sup>282</sup>Department of Obstetrics and Gynecology, Ohio State University College of Medicine, Columbus, OH, USA</div> <div id="A283"> <sup>283</sup>Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark</div> <div id="A284"> <sup>284</sup>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark</div> <div id="A285"> <sup>285</sup>Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</div> <div id="A286"> <sup>286</sup>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark</div> <div id="A287"> <sup>287</sup>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic</div> <div id="A288"> <sup>288</sup>The UQ Centre for Clinical Research, The University of Queensland, The Royal Brisbane and Women's Hospital, Herston, Brisbane, QLD, Australia</div> <div id="A289"> <sup>289</sup>Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA</div> <div class="author-notes p"> <div class="fn" id="FN1"> <sup>*</sup><p class="display-inline" id="P1">These authors contributed equally</p> </div> <div class="fn" id="FN2"> <sup>$</sup><p class="display-inline" id="P2">These authors jointly directed this work</p> </div> <div class="fn" id="CR1"> <sup>✉</sup><p class="display-inline">Correspondence to: Stig E Bojesen, Georgia Chenevix-Trench and Alison M Dunning SEB Department of Clinical Biochemistry, Herlev Hospital Copenhagen University Hospital Herlev Ringvej 75 2730 Herlev Denmark Phone: +45-3868 3843 Fax:+45-3868 3311 <span>stig.egil.bojesen@regionh.dk</span> GC-T The Queensland Institute of Medical Research Locked Bag 2000 Royal Brisbane Hospital, Herston QLD 4029 Australia Phone +61 7 3362 0390 Fax +61 7 3362 0105 <span>georgiaT@qimr.edu.au</span> AMD Centre for Cancer Genetic Epidemiology & Dept. of Oncology, University of Cambridge Strangeways Research Laboratory Worts Causeway Cambridge CB1 8RN, UK Phone +44 (0)1223 740683 <span>amd24@medschl.cam.ac.uk</span></p> </div> </div> </div> <div id="clp_a" class="d-panel p" style="display: none"><div class="p"><a href="/about/copyright/" class="usa-link">PMC Copyright notice</a></div></div> </div> <div>PMCID: PMC3670748 NIHMSID: NIHMS467552 PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/23535731/" class="usa-link">23535731</a> </div> <div class="ra xbox p" role="complementary" aria-label="Related or updated information about this article"><div>The publisher's version of this article is available at <a href="https://doi.org/10.1038/ng.2566" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">Nat Genet</a> </div></div> </div></section></section><section aria-label="Article content"><section class="body main-article-body"><section class="abstract" id="abstract1"><h2>Abstract</h2> <p id="P3"><em>TERT</em>-locus single nucleotide polymorphisms (SNPs) and leucocyte telomere measures are reportedly associated with risks of multiple cancers. Using the iCOGs chip, we analysed ~480 <em>TERT</em>-locus SNPs in breast (n=103,991), ovarian (n=39,774) and <em>BRCA1</em> mutation carrier (11,705) cancer cases and controls. 53,724 participants have leucocyte telomere measures. Most associations cluster into three independent peaks. Peak 1 SNP rs2736108 minor allele associates with longer telomeres (<em>P</em>=5.8×10<sup>−7</sup>), reduced estrogen receptor negative (ER-negative) (<em>P</em>=1.0×10<sup>−8</sup>) and <em>BRCA1</em> mutation carrier (<em>P</em>=1.1×10<sup>−5</sup>) breast cancer risks, and altered promoter-assay signal. Peak 2 SNP rs7705526 minor allele associates with longer telomeres (<em>P</em>=2.3×10<sup>−14</sup>), increased low malignant potential ovarian cancer risk (<em>P</em>=1.3×10<sup>−15</sup>) and increased promoter activity. Peak 3 SNPs rs10069690 and rs2242652 minor alleles increase ER-negative (<em>P</em>=1.2×10<sup>−12</sup>) and <em>BRCA1</em> mutation carrier (<em>P</em>=1.6×10<sup>−14</sup>) breast and invasive ovarian (<em>P</em>=1.3×10<sup>−11</sup>) cancer risks, but not via altered telomere length. The cancer-risk alleles of rs2242652 and rs10069690 respectively increase silencing and generate a truncated <em>TERT</em> splice-variant.</p></section><section id="S1"><h2 class="pmc_sec_title">Introduction</h2> <p id="P4">Chromosome ends are capped by telomeres, which protect them from inappropriate DNA repair and maintain genomic integrity<sup><a href="#R1" class="usa-link" aria-describedby="R1">1</a></sup>. Telomeres consist of structural proteins<sup><a href="#R2" class="usa-link" aria-describedby="R2">2</a></sup> combined with many hundreds of hexanucleotide DNA repeats<sup><a href="#R3" class="usa-link" aria-describedby="R3">3</a>,<a href="#R4" class="usa-link" aria-describedby="R4">4</a></sup>, which are progressively shortened by normal cell division<sup><a href="#R5" class="usa-link" aria-describedby="R5">5</a>–<a href="#R7" class="usa-link" aria-describedby="R7">7</a></sup>. Shortening restricts proliferation of normal somatic cells, but not of cancer cells, which can maintain long telomeres, usually via telomerase<sup><a href="#R8" class="usa-link" aria-describedby="R8">8</a>–<a href="#R10" class="usa-link" aria-describedby="R10">10</a></sup>, and may divide indefinitely. The <em>TERT</em> gene at 5p15.33 (see URLs) encodes the catalytic subunit of telomerase reverse transcriptase, an important component of telomerase. Germline mutations in <em>TERT</em> cause dyskeratosis congenita, a cancer susceptibility disorder characterized by exceedingly short telomeres<sup><a href="#R11" class="usa-link" aria-describedby="R11">11</a></sup>. Although up to 80% of the variation of telomere length is estimated to be due to heritable factors<sup><a href="#R12" class="usa-link" aria-describedby="R12">12</a>,<a href="#R13" class="usa-link" aria-describedby="R13">13</a></sup>, association studies on <em>TERT</em> SNPs and differences in leucocyte telomere length have, to date, been inconclusive<sup><a href="#R14" class="usa-link" aria-describedby="R14">14</a>–<a href="#R17" class="usa-link" aria-describedby="R17">17</a></sup>. Furthermore, it is unclear whether telomere length, measured in leucocyte DNA, is predictive of cancer risk: retrospective studies report that cancer patients, after diagnosis, have shorter telomeres than unaffected controls<sup><a href="#R18" class="usa-link" aria-describedby="R18">18</a>–<a href="#R21" class="usa-link" aria-describedby="R21">21</a></sup>, but prospective studies, with DNA taken prior to diagnosis, have been inconclusive<sup><a href="#R19" class="usa-link" aria-describedby="R19">19</a>,<a href="#R22" class="usa-link" aria-describedby="R22">22</a>,<a href="#R23" class="usa-link" aria-describedby="R23">23</a></sup>. SNPs at 5p15.33 are reported to be associated with risks of several human cancers<sup><a href="#R14" class="usa-link" aria-describedby="R14">14</a>–<a href="#R16" class="usa-link" aria-describedby="R16">16</a>,<a href="#R24" class="usa-link" aria-describedby="R24">24</a>–<a href="#R32" class="usa-link" aria-describedby="R32">32</a></sup>, including certain subtypes of both ovarian<sup><a href="#R33" class="usa-link" aria-describedby="R33">33</a></sup> and breast cancers<sup><a href="#R34" class="usa-link" aria-describedby="R34">34</a></sup>.</p> <p id="P5">Due to a common interest, SNPs surrounding the <em>TERT</em> locus were nominated by members of each of the constituent COGS consortia. Consequently, the iCOGS chip design included a combination of individual <em>TERT</em> gene candidate SNPs, as well as a more comprehensive set to fine-scale map the entire locus, for shared use by all consortia. This study had three aims: to assess SNPs across the <em>TERT</em>-locus for all detectable associations with mean telomere length and breast and ovarian cancer subtypes; to fine-scale map this locus to identify potentially-causal variants for the observed associations; and to evaluate the functional effects of the strongest candidate causative variants.</p></section><section id="S2"><h2 class="pmc_sec_title">Results</h2> <p id="P6">One hundred and ten SNPs at the 5p15.33 locus (Build 37 positions 1,227,693 – 1,361,969) passed quality control tests (QC) in 103,991 breast cancer cases and controls from 52 Breast Cancer Association Consortium (BCAC) studies, of which 41 studies (89,050 individuals) were of European, nine were of Asian (12,893 individuals) and two were of African-American ancestry (2,048 individuals). The same 110 SNPs passed QC in 11,705 <em>BRCA1</em> mutation carriers of European ancestry, recruited by 45 studies from the Consortium of Investigators of Modifiers of <em>BRCA1/2</em> (CIMBA), while 108 SNPs passed QC in 44,308 ovarian cancer cases and controls from 43 Ovarian Cancer Association Consortium (OCAC) studies. For OCAC, analysis was confined to the 39,774 European ancestry participants, of whom 8,371 cases had invasive epithelial ovarian- and 986 had serous low malignant potential (LMP) neoplasia. For all study participants, genotype-imputation, using the 110 genotyped SNPs together with the January 2012 release of the 1000 Genome Project (1000GP)<sup><a href="#R35" class="usa-link" aria-describedby="R35">35</a>–<a href="#R38" class="usa-link" aria-describedby="R38">38</a></sup> was used to increase coverage to ~480 SNPs (imputation r<sup>2</sup>>0.3, minor allele frequency (MAF)>0.02) for each phenotype. Telomere length was initially measured in control subjects from two BCAC studies (SEARCH and CCHS, combined n= 15,567) (see <a href="#SD1" class="usa-link">Supplementary Information</a>).</p> <p id="P7"><a href="#F1" class="usa-link">Figure 1</a> shows Manhattan plots of the genotyped and well-imputed SNPs for the seven phenotypes analyzed: mean telomere length (a), overall breast cancer (b), breast cancer in <em>BRCA1</em> carriers (c), estrogen receptor negative (ER-negative) breast cancer (d), estrogen receptor positive (ER-positive) breast cancer (e), serous LMP ovarian cancer (f) and serous invasive ovarian cancer (g). Conditional analyses within each of these phenotypes revealed multiple independent SNP associations each for telomere length, overall breast cancer, ER-negative breast cancer and overall breast cancer risk in <em>BRCA1</em> mutation carriers, but only one peak each for ER-positive breast cancer, serous LMP and invasive ovarian cancer (<a href="#T1" class="usa-link">Table 1</a>). Full results of all these SNP analyses are given in <a href="#SD1" class="usa-link">Supplementary Tables 1–3</a>. All associations are consistent with a log-additive model.</p> <figure class="fig xbox font-sm" id="F1"><h3 class="obj_head">Figure 1.</h3> <p class="img-box line-height-none margin-x-neg-2 tablet:margin-x-0 text-center"><a class="tileshop" target="_blank" href="https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3670748_nihms-467552-f0001.jpg"><img class="graphic zoom-in" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6098/3670748/763b68803f9e/nihms-467552-f0001.jpg" loading="lazy" height="600" width="449" alt="Figure 1"></a></p> <div class="p text-right font-secondary"><a href="figure/F1/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div> <figcaption><p>Association results for all SNPs for seven phenotypes including: (a) telomere length, (b) overall breast cancer, (c) breast cancer risk in <em>BRCA1</em> mutation carriers, (d) ER-negative breast cancer, (e) ER-positive breast cancer, (f) serous low malignant potential (LMP) ovarian cancer and (g) serous invasive ovarian cancer. Directly-genotyped SNPs are represented by solid black circles and imputed SNPs (r<sup>2</sup>>0.3, minor allele frequency (MAF)>0.02) as open red circles, plotted as the negative log of the <em>P</em>-value against relative position across the locus. Schematics of the gene structures are shown above panel a. Association peaks, as described in the text are labeled at the top of the figure, and are shown as grey regions, when appropriate.</p></figcaption></figure><section class="tw xbox font-sm" id="T1"><h3 class="obj_head">Table 1. Independently-associated SNPs for each phenotype.</h3> <div class="caption p"><p>The independently-associated SNPs are shown for each phenotype following the forward conditional stepwise logistic regression analysis of overall breast cancer and estrogen receptor subgroups in European individuals in BCAC, invasive and LMP subgroups in OCAC, relative change of telomere length (RTL) in the SEARCH and CCHS combined data following the forward stepwise linear regression analysis, and CIMBA <em>BRCA1</em> mutation carriers, following the forward stepwise Cox regression. These analyses were performed on all SNPs with MAF>0.02 and <em>P</em><10<sup>−4</sup> in the single SNP analyses.</p></div> <div class="tbl-box p" tabindex="0"><table class="content" frame="hsides" rules="groups"> <thead><tr> <th align="left" valign="middle" rowspan="1" colspan="1"></th> <th align="center" valign="middle" rowspan="1" colspan="1">SNP</th> <th align="center" valign="middle" rowspan="1" colspan="1">Chr5 position</th> <th align="center" valign="middle" rowspan="1" colspan="1"> <em>TERT</em> Peak</th> <th align="center" valign="middle" rowspan="1" colspan="1">Source</th> <th align="center" valign="middle" rowspan="1" colspan="1">Effect (95%CI)</th> <th align="center" valign="middle" rowspan="1" colspan="1"> <em>P</em>-Trend</th> </tr></thead> <tbody> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>Telomere length (RTL)</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">BCAC (SEARCH & CCHS)</td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <em>n=15567</em> </td> <td align="center" valign="middle" rowspan="1" colspan="1">rs2736108</td> <td align="center" valign="middle" rowspan="1" colspan="1">1297488</td> <td align="center" valign="middle" rowspan="1" colspan="1">1</td> <td align="center" valign="middle" rowspan="1" colspan="1">Genotyped</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.010 (1.004–1.016)</td> <td align="center" valign="middle" rowspan="1" colspan="1">0.0004</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1">rs7705526</td> <td align="center" valign="middle" rowspan="1" colspan="1">1285974</td> <td align="center" valign="middle" rowspan="1" colspan="1">2</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.019 (1.014–1.025)</td> <td align="center" valign="middle" rowspan="1" colspan="1">2.47E-11</td> </tr> <tr><td colspan="7" align="left" valign="middle" rowspan="1"> <hr> </td></tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>Overall breast cancer</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">BCAC</td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <em>46451 cases, 42599 controls</em> </td> <td align="center" valign="middle" rowspan="1" colspan="1">rs3215401</td> <td align="center" valign="middle" rowspan="1" colspan="1">1296255</td> <td align="center" valign="middle" rowspan="1" colspan="1">1</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">0.94 (0.91–0.96)</td> <td align="center" valign="middle" rowspan="1" colspan="1">9.91E-10</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1">rs7734992</td> <td align="center" valign="middle" rowspan="1" colspan="1">1280128</td> <td align="center" valign="middle" rowspan="1" colspan="1">2</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.06 (1.04–1.08)</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.73E-07</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1">rs56963355</td> <td align="center" valign="middle" rowspan="1" colspan="1">1251503</td> <td align="center" valign="middle" rowspan="1" colspan="1">None</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">0.90 (0.84–0.95)</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.95E-05</td> </tr> <tr><td colspan="7" align="left" valign="middle" rowspan="1"> <hr> </td></tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>Risk of breast cancer in <em>BRCA1</em> carriers</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">CIMBA</td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <em>n=11705</em> </td> <td align="center" valign="middle" rowspan="1" colspan="1">rs2736108</td> <td align="center" valign="middle" rowspan="1" colspan="1">1297488</td> <td align="center" valign="middle" rowspan="1" colspan="1">1</td> <td align="center" valign="middle" rowspan="1" colspan="1">Genotyped</td> <td align="center" valign="middle" rowspan="1" colspan="1">0.92 (0.88–0.96)</td> <td align="center" valign="middle" rowspan="1" colspan="1">5.12E-05</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1">rs10069690</td> <td align="center" valign="middle" rowspan="1" colspan="1">1279790</td> <td align="center" valign="middle" rowspan="1" colspan="1">3</td> <td align="center" valign="middle" rowspan="1" colspan="1">Genotyped</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.16 (1.11–1.21)</td> <td align="center" valign="middle" rowspan="1" colspan="1">4.83E-13</td> </tr> <tr><td colspan="7" align="left" valign="middle" rowspan="1"> <hr> </td></tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>Estrogen receptor negative breast cancer</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">BCAC</td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <em>7435 cases, 41575 controls</em> </td> <td align="center" valign="middle" rowspan="1" colspan="1">rs3215401</td> <td align="center" valign="middle" rowspan="1" colspan="1">1296255</td> <td align="center" valign="middle" rowspan="1" colspan="1">1</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">0.91 (0.86–0.95)</td> <td align="center" valign="middle" rowspan="1" colspan="1">6.15E-06</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1">rs2242652</td> <td align="center" valign="middle" rowspan="1" colspan="1">1280028</td> <td align="center" valign="middle" rowspan="1" colspan="1">3</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.15 (1.10–1.20)</td> <td align="center" valign="middle" rowspan="1" colspan="1">4.29E-09</td> </tr> <tr><td colspan="7" align="left" valign="middle" rowspan="1"> <hr> </td></tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>Estrogen receptor positive breast cancer</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">BCAC</td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <em>27074 cases, 41749 controls</em> </td> <td align="center" valign="middle" rowspan="1" colspan="1">rs2736107</td> <td align="center" valign="middle" rowspan="1" colspan="1">1297854</td> <td align="center" valign="middle" rowspan="1" colspan="1">1</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">0.95 (0.92–0.97)</td> <td align="center" valign="middle" rowspan="1" colspan="1">3.32E-05</td> </tr> <tr><td colspan="7" align="left" valign="middle" rowspan="1"> <hr> </td></tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>Serous LMP ovarian cancer</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">OCAC</td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <em>986 cases, 23491 controls</em> </td> <td align="center" valign="middle" rowspan="1" colspan="1">rs7705526</td> <td align="center" valign="middle" rowspan="1" colspan="1">1285974</td> <td align="center" valign="middle" rowspan="1" colspan="1">2</td> <td align="center" valign="middle" rowspan="1" colspan="1">Imputed</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.51 (1.36–1.67)</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.34E-15</td> </tr> <tr><td colspan="7" align="left" valign="middle" rowspan="1"> <hr> </td></tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>Serous invasive ovarian cancer</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">OCAC</td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <em>8371 cases, 23491 controls</em> </td> <td align="center" valign="middle" rowspan="1" colspan="1">rs10069690</td> <td align="center" valign="middle" rowspan="1" colspan="1">1279790</td> <td align="center" valign="middle" rowspan="1" colspan="1">3</td> <td align="center" valign="middle" rowspan="1" colspan="1">Genotyped</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.15 (1.11–1.20)</td> <td align="center" valign="middle" rowspan="1" colspan="1">1.25E-11</td> </tr> </tbody> </table></div> <div class="p text-right font-secondary"><a href="table/T1/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div></section><section id="S3"><h3 class="pmc_sec_title">Associations with telomere length</h3> <p id="P8">SNPs in two distinct regions (hereafter denoted Peaks 1 and 2) are strongly associated with telomere length (<a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>; <a href="#F1" class="usa-link">Fig.1</a>, <strong>panel a</strong>; <a href="#SD1" class="usa-link">Supplementary Fig.1</a>, <strong>panel a</strong>). Imputed SNP rs7705526 (Peak 2, position 1285974, <em>TERT</em> intron 2) has the largest effect with a change in relative telomere length of 1.026-fold per-allele (95%CI 1.019–1.033, <em>P</em>=2.3×10<sup>−14</sup>, conditional <em>P</em>=2.5×10<sup>−11</sup>). We confirmed this finding in an additional 20,512 women and 17,645 men from a third study (CGPS) genotyped for rs7726159 (the best directly-genotyped SNP; r<sup>2</sup>=0.83 with rs7705526). From a joint analysis of all 53,724 individuals, the change in relative telomere length is 1.020-fold per-allele (95%CI 1.016–1.023, <em>P</em>=7.5×10<sup>−28</sup>). A second, independent association was observed with rs2736108 (Peak 1, position 1297488, <em>TERT</em> promoter) with a per-allele change in relative telomere length of 1.017-fold (95%CI 1.010–1.024, <em>P</em>=5.8×10<sup>−7</sup>, conditional <em>P</em>=4.0×10<sup>−4</sup>) (<a href="#F1" class="usa-link">Fig.1</a>, <strong>panel a</strong>; <a href="#SD1" class="usa-link">Supplementary Fig.1</a>, <strong>panel a</strong>; <a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>). SNPs rs7705526 and rs2736108 are only weakly correlated (r<sup>2</sup>=0.04 in Europeans). Weak associations between Peak 3 SNPs and telomere length became non-significant after adjustment for Peak 2 SNP rs7705526 (data not shown).</p> <section class="tw xbox font-sm" id="T2"><h4 class="obj_head">Table 2. Association between TERT SNPs and the seven studied phenotypes.</h4> <div class="caption p"><p>Single SNP estimates for the most significant SNPs per peak per phenotype in the <em>TERT</em> fine mapping region of Chromosome 5 from position 1227014 to 1361964 (genome build 37). The major and minor alleles are from the genotyping assay and not necessarily from the coding strand. The change in telomere length per minor allele is given as fold-change (RTL) with respect to the estimated telomere length for the common homozygote per SNP, both with 95%CI (see <strong>Supplementary Methods</strong>). All breast and ovarian cancer risk results are given as odds ratios (OR) with 95% confidence intervals (CI) and per-allele <em>P</em>-trend, and the <em>BRCA1</em> carrier risk results are given as hazard ratios (HR) with 95%CI. All SNPs that cannot be excluded as >100× worse than the top hit in the block for any phenotype are listed. The independent Peaks 1–3 were localized using forward conditional analyses described in <a href="#T1" class="usa-link">Table 1</a>. The most significant hit in each region for each phenotype is emboldened for each peak. The results of the SNPs emerging as most significant in each block in the forward conditional analyses, and described further in <a href="#T1" class="usa-link">Table 1</a>, are marked with an asterisk. Genotyped SNPs are marked with a hash tag; all three peaks contain at least one directly genotyped variant.</p></div> <div class="tbl-box p" tabindex="0"><table class="content" frame="hsides" rules="groups"> <thead> <tr> <th rowspan="2" align="left" valign="middle" colspan="1">SNP</th> <th rowspan="2" align="left" valign="middle" colspan="1">Chr 5 position</th> <th rowspan="2" align="center" valign="middle" colspan="1">Major/ minor allele</th> <th rowspan="2" align="left" valign="middle" colspan="1">MAF</th> <th align="left" valign="middle" rowspan="1" colspan="1">Telomere length change</th> <th align="left" valign="middle" rowspan="1" colspan="1">Overall breast cancer risk</th> <th align="left" valign="middle" rowspan="1" colspan="1">Risk of breast cancer in <em>BRCA1</em> Carriers</th> <th align="left" valign="middle" rowspan="1" colspan="1">Estrogen receptor negative breast cancer risk</th> <th align="left" valign="middle" rowspan="1" colspan="1">Estrogen receptor positive breast cancer risk</th> <th align="left" valign="middle" rowspan="1" colspan="1">Serous low malignant potential ovarian cancer risk</th> <th align="left" valign="middle" rowspan="1" colspan="1">Serous invasive epithelial ovarian cancer risk</th> </tr> <tr> <th align="left" valign="middle" rowspan="1" colspan="1">RTL (95%CI), <em>P</em>-trend</th> <th align="left" valign="middle" rowspan="1" colspan="1">OR (95%CI), <em>P</em>-trend</th> <th align="left" valign="middle" rowspan="1" colspan="1">HR (95%CI), <em>P</em>-trend</th> <th align="left" valign="middle" rowspan="1" colspan="1">OR (95%CI), <em>P</em>-trend</th> <th align="left" valign="middle" rowspan="1" colspan="1">OR (95%CI), <em>P</em>-trend</th> <th align="left" valign="middle" rowspan="1" colspan="1">OR (95%CI), <em>P</em>-trend</th> <th align="left" valign="middle" rowspan="1" colspan="1">OR (95%CI), <em>P</em>-trend</th> </tr> </thead> <tbody> <tr> <td colspan="2" align="left" valign="middle" rowspan="1"> <strong>Peak 1 - Promoter</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs2736107</td> <td align="left" valign="middle" rowspan="1" colspan="1">1297854</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/T</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.28</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.015 (1.009–1.022), 8.33E-07</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.93 (0.91–0.96), 7.95E-10</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.90 (0.86–0.95), 0.00013</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.88 (0.83–0.93), 1.41E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*0.95 (0.92–0.97), 3.32E-05</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">1.01 (0.91–1.11), 0.909</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.98 (0.94–1.02), 0.301</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <sup>#</sup>rs2736108</td> <td align="left" valign="middle" rowspan="1" colspan="1">1297488</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/T</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.29</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*1.017 (1.010–1.024), 5.81E-07</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">0.94 (0.92–0.95), 6.73E-09</td> <td align="left" valign="middle" rowspan="1" colspan="1">*0.89 (0.85–0.94), 1.05E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.89 (0.84–0.93), 1.01E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.96 (0.93–0.98), 0.00051</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.00 (0.91–1.10), 0.996</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.98 (0.94–1.02), 0.238</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs72525896</td> <td align="left" valign="middle" rowspan="1" colspan="1">1297081</td> <td align="center" valign="middle" rowspan="1" colspan="1">CCA/C</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.27</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.016 (1.009–1.023), 7.13E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.94 (0.92–0.96), 1.20E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>0.88 (0.84–0.93), 1.04E-05</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">0.88 (0.84–0.92), 1.21E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.96 (0.93–0.98), 0.00083</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.02 (0.92–1.13), 0.762</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.98 (0.94–1.02), 0.324</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">5-1297077</td> <td align="left" valign="middle" rowspan="1" colspan="1">1297077</td> <td align="center" valign="middle" rowspan="1" colspan="1">ACC/A</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.27</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.016 (1.009–1.023), 7.13E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.94 (0.92–0.96), 1.91E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.89 (0.84–0.94), 1.90E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.88 (0.84–0.93), 1.37E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.96 (0.93–0.98), 0.00051</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.02 (0.92–1.13), 0.769</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.98 (0.94–1.02), 0.351</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs3215401</td> <td align="left" valign="middle" rowspan="1" colspan="1">1296255</td> <td align="center" valign="middle" rowspan="1" colspan="1">A/AG</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.30</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.016 (1.009–1.023), 1.63E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*0.94 (0.91–0.96), 4.68E-10</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">0.90 (0.85–0.94), 3.05E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*0.88 (0.84–0.92), 1.19E-09</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">0.95 (0.93–0.98), 0.0012</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.01 (0.91–1.11), 0.908</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.98 (0.94–1.01), 0.188</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs2853669</td> <td align="left" valign="middle" rowspan="1" colspan="1">1295349</td> <td align="center" valign="middle" rowspan="1" colspan="1">A/G</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.30</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.016 (1.009–1.024), 2.95E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.94 (0.92–0.96), 4.01E-09</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.90 (0.85–0.94), 4.26E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.88 (0.84–0.92), 2.60E-09</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.96 (0.93–0.98), 0.00034</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.01 (0.91–1.11), 0.893</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.97 (0.94–1.01), 0.204</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs2736098</td> <td align="left" valign="middle" rowspan="1" colspan="1">1294086</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/T</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.27</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.017 (1.010–1.024), 1.35E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.93 (0.91–0.96), 6.65E-10</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.89 (0.85–0.94), 4.22E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.88 (0.84–0.93), 2.41E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.95 (0.92–0.97), 4.58E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.00 (0.91–1.11), 0.935</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.97 (0.93–1.01), 0.152</td> </tr> <tr> <td colspan="2" align="left" valign="middle" rowspan="1"> <strong>Peak 2 - Intron 2–4</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs7705526</td> <td align="left" valign="middle" rowspan="1" colspan="1">1285974</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/A</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.33</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*1.026 (1.019–1.033), 2.32E-14</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">1.04 (1.02–1.06), 0.00011</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.04 (0.99–1.10), 0.120</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.06 (1.02–1.10), 0.0035</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.04 (1.01–1.06), 0.0049</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*1.51 (1.36–1.67), 1.34E-15</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">1.11 (1.06–1.15), 6.38E-07</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs4449583</td> <td align="left" valign="middle" rowspan="1" colspan="1">1284135</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/T</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.34</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.025 (1.018–1.031), 1.93E-13</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.04 (1.02–1.06), 4.75E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.08 (1.03–1.14), 0.002</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.08 (1.04–1.12), 9.68E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.03 (1.01–1.06), 0.014</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.49 (1.35–1.64), 2.18E-15</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.13 (1.08–1.17), 5.38E-09</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <sup>#</sup>rs7725218</td> <td align="left" valign="middle" rowspan="1" colspan="1">1282414</td> <td align="center" valign="middle" rowspan="1" colspan="1">G/A</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.35</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.021 (1.015–1.028), 1.10E-10</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.04 (1.02–1.06), 1.95E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.10 (1.05–1.16), 7.47E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.08 (1.04–1.12), 9.29E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.03 (1.01–1.06), 0.0083</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.42 (1.29–1.56), 7.24E-13</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.12 (1.08–1.17), 2.08E-09</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <sup>#</sup>rs7726159</td> <td align="left" valign="middle" rowspan="1" colspan="1">1282319</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/A</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.34</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.024 (1.017–1.031), 4.52E-13</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.05 (1.03–1.07), 1.29E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.09 (1.04–1.15), 0.00047</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.09 (1.05–1.13), 2.23E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.03 (1.01–1.06), 0.0090</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.44 (1.31–1.59), 4.50E-14</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.12 (1.08–1.17), 4.59E-09</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">5-1280940</td> <td align="left" valign="middle" rowspan="1" colspan="1">1280940</td> <td align="center" valign="middle" rowspan="1" colspan="1">GAGCCCACC/G</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.37</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.023 (1.016–1.029), 1.62E-11</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.05 (1.03–1.07), 1.62E-05</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.10 (1.04–1.15), 0.00038</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.10 (1.06–1.14), 5.02E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.03 (1.00–1.05), 0.021</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.44 (1.30–1.59), 9.83E-13</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.12 (1.08–1.17), 9.46E-09</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs7734992</td> <td align="left" valign="middle" rowspan="1" colspan="1">1280128</td> <td align="center" valign="middle" rowspan="1" colspan="1">T/C</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.43</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.019 (1.013–1.025), 2.23E-09</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*1.05 (1.03–1.07), 2.06E-06</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">1.10 (1.05–1.15), 0.00017</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.10 (1.06–1.14), 1.57E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.03 (1.01–1.06), 0.0053</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.45 (1.31–1.59), 5.25E-14</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.12 (1.08–1.16), 2.75E-09</td> </tr> <tr> <td colspan="2" align="left" valign="middle" rowspan="1"> <strong>Peak 3 - Intron 2–4</strong> </td> <td align="center" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> <td align="left" valign="middle" rowspan="1" colspan="1"></td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs72709458</td> <td align="left" valign="middle" rowspan="1" colspan="1">1283755</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/T</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.22</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.012 (1.005–1.020), 0.0010</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.07 (1.04–1.09), 1.02E-07</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.19 (1.12–1.25), 5.61E-09</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.17 (1.12–1.21), 2.34E-11</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.04 (1.01–1.06), 0.014</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.45 (1.30–1.61), 1.96E-11</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.15 (1.10–1.20), 3.04E-09</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1">rs2242652</td> <td align="left" valign="middle" rowspan="1" colspan="1">1280028</td> <td align="center" valign="middle" rowspan="1" colspan="1">G/A</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.20</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.009 (1.002–1.017), 0.016</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.06 (1.03–1.08), 6.82E-06</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.25 (1.18–1.32), 6.89E-14</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*1.18 (1.14–1.23), 1.23E-12</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">1.02 (0.99–1.05), 0.131</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.40 (1.25–1.56), 4.45E-09</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.17 (1.12–1.22), 4.85E-11</td> </tr> <tr> <td align="left" valign="middle" rowspan="1" colspan="1"> <sup>#</sup>rs10069690</td> <td align="left" valign="middle" rowspan="1" colspan="1">1279790</td> <td align="center" valign="middle" rowspan="1" colspan="1">C/T</td> <td align="left" valign="middle" rowspan="1" colspan="1">0.26</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.009 (1.002–1.016), 0.013</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.06 (1.04–1.08), 2.43E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*1.23 (1.16–1.29), 1.60E-14</strong> </td> <td align="left" valign="middle" rowspan="1" colspan="1">1.16 (1.12–1.20), 1.68E-12</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.03 (1.01–1.06), 0.011</td> <td align="left" valign="middle" rowspan="1" colspan="1">1.33 (1.20–1.47), 2.49E-08</td> <td align="left" valign="middle" rowspan="1" colspan="1"> <strong>*1.15 (1.11–1.20), 1.25E-11</strong> </td> </tr> </tbody> </table></div> <div class="p text-right font-secondary"><a href="table/T2/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div> <div class="tw-foot p"><div class="fn" id="_fn_p47"><p>MAF: minor allele frequency.</p></div></div></section></section><section id="S4"><h3 class="pmc_sec_title">Associations with breast cancer risk</h3> <p id="P9">We identified SNPs associated with breast cancer risk (<em>P</em><10<sup>−4</sup>) in three distinct regions in BCAC studies and two in CIMBA <em>BRCA1</em> mutation carriers. No significant (<em>P</em><10<sup>−4</sup>) evidence for heterogeneity among odds ratios (OR) or hazard ratios (HR) between studies for any of the top SNPs was observed (<a href="#SD1" class="usa-link">Supplementary Fig.6</a>). The strongest association with overall breast cancer risk in BCAC is with Peak 1 SNP rs3215401 (<a href="#F1" class="usa-link">Fig.1</a>, <strong>panel b</strong>; <a href="#SD1" class="usa-link">Supplementary Fig.1</a>, <strong>panel b</strong>; <a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>). There is also good evidence for an association with SNPs in Peak 2 and weaker evidence for an additional SNP, outside the three main association peaks, to be independently associated with breast cancer risk (<a href="#SD1" class="usa-link">Supplementary Table 1</a>; <a href="#T1" class="usa-link">Table 1</a>). The most strongly-associated SNPs in <em>BRCA1</em> mutation carriers are located in introns 2–4 (hereafter denoted Peak 3) including rs10069690 (<a href="#F1" class="usa-link">Fig.1</a>, <strong>panel c</strong>; <a href="#SD1" class="usa-link">Supplementary Fig.2</a>, <strong>panel c</strong>; <a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>) and rs2242652 (correlation with rs10069690, r<sup>2</sup>= 0.70). The latter SNP also exhibits the strongest association with ER-negative breast cancer in BCAC (<a href="#F1" class="usa-link">Fig. 1</a>, <strong>panel d</strong>; <a href="#SD1" class="usa-link">Supplementary Fig. 1</a>, <strong>panel d</strong>; <a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>), but shows little evidence of association with ER-positive breast cancer (<a href="#T2" class="usa-link">Table 2</a>). Stepwise regression analysis in CIMBA studies indicated two independent associations with breast cancer risk in <em>BRCA1</em> mutation carriers (conditional <em>P</em>=5×10<sup>−5</sup> for rs2736108 in Peak 1; <em>P</em>=4.8×10<sup>−13</sup> for rs10069690 in Peak 3). A very similar pattern was observed for ER-negative breast cancer in BCAC (conditional <em>P</em>=6×10<sup>−6</sup> for rs3215401 in Peak 1 and <em>P</em>=4.3×10<sup>−9</sup> for rs2242652 in Peak 3; <a href="#T1" class="usa-link">Table 1</a>). The most strongly associated SNP with ER-positive breast cancer is rs2736107 in Peak 1 (<a href="#F1" class="usa-link">Fig.1</a>, <strong>panel e</strong>; <a href="#SD1" class="usa-link">Supplementary Fig.2</a>, <strong>panel e</strong>; <a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>). Weak associations between the key SNPs and risk for <em>BRCA2</em> mutation carriers are also observed, but the sample size is too small to draw definitive conclusions (data not shown).</p></section><section id="S5"><h3 class="pmc_sec_title">Associations with ovarian cancer risk</h3> <p id="P10">The strongest association observed for risk of LMP ovarian cancer is with Peak 2 SNP rs7705526 and this is the only SNP retained in the stepwise regression analysis (<a href="#F1" class="usa-link">Fig.1</a>, <strong>panel f</strong>; <a href="#SD1" class="usa-link">Supplementary Fig.1</a>, <strong>panel f</strong>; <a href="#T1" class="usa-link">Table 1</a> and <a href="#T2" class="usa-link">2</a>). The strongest observed association for serous invasive ovarian cancer is with Peak 3 SNP rs10069690 (<a href="#F1" class="usa-link">Fig.1</a>, <strong>panel g</strong>; <a href="#SD1" class="usa-link">Supplementary Fig.1</a>, <strong>panel g</strong>; <a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>). No other independent associations were observed for serous invasive ovarian cancer (<a href="#T1" class="usa-link">Table 1</a>). We also analysed SNP associations with endometrioid, mucinous, clear cell invasive and mucinous LMP ovarian cancers but found no associations at <em>P</em><10<sup>−4</sup> (<a href="#SD1" class="usa-link">Supplementary Table 4</a>). We attempted analysis of invasive serous ovarian cancer stratified by grade, but again statistical power was low (<a href="#SD1" class="usa-link">Supplementary Fig.2</a>).</p></section><section id="S6"><h3 class="pmc_sec_title">Three main peaks of association within the <em>TERT</em> locus</h3> <p id="P11">The above results indicate that the majority of observed associations with all seven tested phenotypes fall into association Peaks 1–3. Correlated SNPs in the <em>TERT</em> promoter (Peak 1) are associated with telomere length, ER-positive breast cancer, ER-negative breast cancer and breast cancer in <em>BRCA1</em> mutation carriers. SNPs in Peak 2, spanning <em>TERT</em> introns 2–4, are independently associated with telomere length, overall breast cancer and serous LMP ovarian cancer. Finally, SNPs in Peak 3, also spanning <em>TERT</em> introns 2–4, display strong associations with ER-negative breast cancer, breast cancer risk for <em>BRCA1</em> mutation carriers and serous invasive ovarian cancer, but not with telomere length (<a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a>). Although Peaks 2 and 3 overlap physically, they define distinct sets of SNPs that are only partially correlated (e.g. correlation between rs10069690 and rs7705526; r<sup>2</sup>=0.33; <a href="#F2" class="usa-link">Fig.2</a>). Some SNP-phenotype associations in Peak 2 are clearly weaker than those in Peak 3 (e.g. with ER-negative breast cancer) and become non- significant after adjustment for SNP rs2242652 in Peak 3. Conversely, the associations with telomere length and serous LMP ovarian cancer are stronger for SNPs in Peak 2, indicating that the associations in Peaks 2 and 3 are not being driven by the same causal variants.</p> <figure class="fig xbox font-sm" id="F2"><h4 class="obj_head">Figure 2.</h4> <p class="img-box line-height-none margin-x-neg-2 tablet:margin-x-0 text-center"><a class="tileshop" target="_blank" href="https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3670748_nihms-467552-f0002.jpg"><img class="graphic zoom-in" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6098/3670748/12221f38a8a6/nihms-467552-f0002.jpg" loading="lazy" height="442" width="600" alt="Figure 2"></a></p> <div class="p text-right font-secondary"><a href="figure/F2/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div> <figcaption><p>Associated signals within the <em>TERT</em> gene. Peak regions described in the text are labeled: Peaks 2 and 3 overlap around introns 2–4, and Peak 1 encompasses the promoter. The positions of associated SNPs are shown as black and red ticks representing genotyped and imputed SNPs, respectively. The <em>TERT</em> gene structure is depicted with exons (boxes) joined by introns (lines). The positions of all analyzed iCOGS SNPs are marked. Data from the UCSC genome browser including epigenetic marks for H3K4Me1 and H3K4Me3, ESPERR regulatory potential, and vertebrate conservation tracks are shown. Regions cloned into reporter constructs are depicted as the green bar (<em>TERT</em> promoter) or blue bars (PRE-A and PRE-B). The pattern of linkage disequilibrium based on the BCAC population is shown where white represents r<sup>2</sup>=0 and black r<sup>2</sup>=1.</p></figcaption></figure><p id="P12">The strongest candidates for causation within each peak were identified by computing likelihood ratios; the SNPs listed in <a href="#T1" class="usa-link">Tables 1</a> and <a href="#T2" class="usa-link">2</a> are those that cannot be excluded at a likelihood ratio of >1:100 fold compared to the top hit in the peak. The power to exclude SNPs differs between phenotypes; in Peak 1, all but seven SNPs can be excluded from being causal for relative telomere length, breast cancer risk in <em>BRCA1</em> mutation carriers and ER-negative risk, but an additional SNP can be excluded for ER-positive breast cancer risk (<a href="#T2" class="usa-link">Table 2</a>). In Peak 2, the greatest power is for the telomere length phenotype, where all but three SNPs can be excluded, whilst five or six remain for cancer risk. For Peak 3, three putative causal SNPs remain for ER-negative breast cancer risk, two for serous invasive ovarian cancer risk and just one for breast cancer risk in <em>BRCA1</em> carriers. Results in each peak are compatible with a single causative variant being responsible for the multiple phenotype associations (n.b. in Peak 3, SNPs rs2242652 and rs10069690 are equally compatible with being the single causal variant). However the possibilities of different causal variants being responsible for different phenotypes, or of the associations being due to haplotype effects, cannot be ruled out.</p></section><section id="S7"><h3 class="pmc_sec_title">Asian and African studies</h3> <p id="P13">We tested all SNPs (n=341) with MAF >0.02 and imputation r<sup>2</sup>>0.3 for association with breast cancer in the nine BCAC Asian studies (comprising 6,269 cases and 6,624 controls) but none reached formal levels of significance. Furthermore none of the European top SNPs displayed more than borderline levels of significance in Asians (<a href="#SD1" class="usa-link">Supplementary Table 5</a>). Peak 3 SNP rs10069690 was directly genotyped in two BCAC African-American studies (1,116 cases and 932 controls), as well as the above mentioned Asian studies and has estimated effects on ER-negative breast cancer similar to those in European populations: per-allele OR=1.19, 95%CI 1.06–1.31, <em>P</em>=0.009 in African-Americans and OR=1.09, 95%CI 1.00–1.19, <em>P</em>=0.07 in Asian women. Within OCAC there were too few women of Asian and African ethnicity to draw meaningful conclusions. (<a href="#SD1" class="usa-link">Supplementary Table 6</a>).</p></section><section id="S8"><h3 class="pmc_sec_title">Functional and <em>in silico</em> analyses</h3> <section id="S9"><h4 class="pmc_sec_title">Chromatin analysis</h4> <p id="P14">Analysis of the ENCyclopedia Of DNA Elements (ENCODE) data<sup><a href="#R39" class="usa-link" aria-describedby="R39">39</a></sup> revealed no evidence of regulatory elements or open chromatin coinciding with any risk-associated SNPs in normal breast epithelial cells or the other represented tissues (<a href="#SD1" class="usa-link">Supplementary Fig.3</a>) (Data for ovarian tissues are not included in ENCODE). We therefore performed site-specific formaldehyde-assisted isolation of regulatory elements (FAIRE<sup><a href="#R40" class="usa-link" aria-describedby="R40">40</a></sup>) in ovarian cancer precursor tissues to identify regulatory elements in a 1Mb region centred on Peak 3. In fallopian tube secretory- and ovarian surface- epithelial cells, we detected FAIRE peaks coinciding with the <em>CLPTM1L</em> promoter but not the <em>TERT</em> promoter (<a href="#SD1" class="usa-link">Supplementary Fig.3</a>). <em>In silico</em> analyses additionally indicated that <em>TERT</em> introns 4 and 5 (within and beyond Peak 3) contain regions showing regulatory potential and vertebrate sequence conservation<sup><a href="#R41" class="usa-link" aria-describedby="R41">41</a></sup>. We used site-specific FAIRE analyses of a ~1 kb region centered on the Peak 3 SNP rs10069690 in normal tissue samples from breast reduction mammoplasty (n=4), ovarian cancer precursor tissues (n=4) and ovarian cancer cell-lines (n=4). Breast cells from each woman were sorted into four enriched fractions based on differential expression of cell surface markers<sup><a href="#R42" class="usa-link" aria-describedby="R42">42</a></sup> (myoepithelial/stem, luminal progenitor, mature luminal and stromal) and assays were performed on each fraction (<a href="#F3" class="usa-link">Fig.3</a>). Chromatin was closed in all the ovarian, breast luminal progenitor and mature luminal fractions. However, in 2/4 stromal cell fractions, we detected ~600bp open chromatin of varying amplitude, covering the position of SNP rs10069690, but not of rs2242652, and in 3/4 myoepithelial/stem cell fractions, we detected ~800bp open chromatin, covering the positions of both SNPs rs10069690 and rs2242652.</p> <figure class="fig xbox font-sm" id="F3"><h5 class="obj_head">Figure 3.</h5> <p class="img-box line-height-none margin-x-neg-2 tablet:margin-x-0 text-center"><a class="tileshop" target="_blank" href="https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3670748_nihms-467552-f0003.jpg"><img class="graphic zoom-in" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6098/3670748/f49d51d94542/nihms-467552-f0003.jpg" loading="lazy" height="499" width="600" alt="Figure 3"></a></p> <div class="p text-right font-secondary"><a href="figure/F3/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div> <figcaption><p>Open chromatin signatures around rs10069690. (A) Map of the PCR amplicon sites A-D used to annotate a 1 kilobase region surrounding rs10069690 and rs2442652. Primer sequences are listed in <a href="#SD1" class="usa-link">Supplementary Table 11</a>. (B) PCR analysis of FAIRE-processed chromatin from FACS-sorted myoepithelial/stem, luminal progenitor, mature luminal and stromal cell enriched fractions derived from breast tissues of four subjects Q695, Q723, Q706, and Q674. Error bars represent standard errors of triplicate PCR reactions.</p></figcaption></figure></section><section id="S10"><h4 class="pmc_sec_title">Luciferase reporter assays</h4> <p id="P15">The regulatory capabilities of the DNA in each of the three peaks, and the effects of most of the strongest candidate causative variants in each one, were examined in luciferase reporter assays, using a construct containing 3915bp of the <em>TERT</em> promoter sequence<sup><a href="#R43" class="usa-link" aria-describedby="R43">43</a></sup>. Effects of Peak 1 <em>TERT</em> promoter variants were examined via five haplotype constructs differing at rs2736107, rs2736108 and rs2736109<sup><a href="#R25" class="usa-link" aria-describedby="R25">25</a></sup> (<a href="#F4" class="usa-link">Fig.4a</a>): one with all three major alleles (<em>TERT</em> wt), another with all three minor alleles (rs2736107, rs2736108, and rs2736109), and three with minor alleles of each SNP individually. Relative promoter activity was determined in ER-positive (MCF7), ER-negative (MDA-MB-468) breast and ovarian (A2780) cancer cell-lines. The construct containing all three minor alleles consistently generated the lowest luciferase signals, close to baseline. To determine whether the risk-associated variants in Peaks 2 and 3 fall within putative <em>cis</em>-acting regulatory elements (PREs), we cloned ~3 kb of sequence surrounding each SNP. Constructs of PRE-A (Peak 2) had no significant effect on the activity of either promoter construct (<a href="#F4" class="usa-link">Fig.4b</a>). However, inclusion of the minor allele of rs7705526 increased <em>TERT</em> promoter activity by ~30% in all three cell-lines, suggesting that it can act as a transcriptional enhancer. This increase in promoter activity was also observed with the construct in A2780 ovarian cells, but not in the two breast cancer cell-lines. Constructs of PRE-B (Peak 3) consistently act as strong transcriptional silencers, leading to a 40–50% decrease in activity, specifically in constructs containing the <em>TERT</em> wt promoter. Notably, inclusion of the minor allele of rs2242652 in PRE-B constructs decreased relative <em>TERT</em> wt promoter activity by a further ~20% compared to the silencer containing the major alleles, but highly-correlated SNP rs10069690 did not generate this effect (<a href="#F4" class="usa-link">Fig.4b</a>).</p> <figure class="fig xbox font-sm" id="F4"><h5 class="obj_head">Figure 4.</h5> <p class="img-box line-height-none margin-x-neg-2 tablet:margin-x-0 text-center"><a class="tileshop" target="_blank" href="https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=3670748_nihms-467552-f0004.jpg"><img class="graphic zoom-in" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6098/3670748/94e6acbf9d1f/nihms-467552-f0004.jpg" loading="lazy" height="463" width="600" alt="Figure 4"></a></p> <div class="p text-right font-secondary"><a href="figure/F4/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div> <figcaption><p><em>TERT</em> promoter and putative regulatory element (PRE) activity. Luciferase reporter assays following transient transfection of ER-negative breast cancer cell line (MDA-MB-468), ER-positive breast cancer cell line (MCF7), and ovarian cancer cell line (A2780). Error bars represent standard error between at least three separate experiments. (a-c) Luciferase reporter assays following transient transfection with pGL2-control (SV40 promoter and enhancer), pGL2-basic (lacks promoter and enhancer), and the <em>TERT</em> reporter vectors <em>TERT</em> wildtype (wt) (3.9kb of <em>TERT</em> promoter), the minor (T) alleles of rs2736107, rs2736108, rs2736109, and rs2736107/8/9 (T-alleles at all sites). Comparisons with <em>TERT</em> wt performed using one-way ANOVA with post hoc Dunnett's tests are represented by ** (<em>P</em>-value <0.001) and * (<em>P</em>-value 0.005).</p> <p>(d–f) PRE-A or PRE-B were cloned downstream of either the <em>TERT</em> wt or <em>TERT</em> rs2736107/8/9 (<em>TERTh</em>) promoter-driven reporters with and without SNPs rs10069690, rs2242652 and rs7705526. Comparisons with <em>TERT</em> wt or <em>TERTh</em> performed using one way ANOVA with post hoc Dunnett's tests are represented by *** (<em>P</em>-value <0.0001) and ** (<em>P</em>-value <0.001).</p></figcaption></figure></section><section id="S11"><h4 class="pmc_sec_title">Alternative splicing of TERT</h4> <p id="P16">Several <em>TERT</em> alternative splice variants have been found to impact on telomerase activity<sup><a href="#R44" class="usa-link" aria-describedby="R44">44</a>,<a href="#R45" class="usa-link" aria-describedby="R45">45</a></sup>. To determine the role of PRE-B (Peak 3) SNPs in <em>TERT</em> alternative splicing, we inserted intron 4 sequence into a full length <em>TERT</em> cDNA mini-gene construct, and confirmed accurate splicing. Cancer risk-associated alleles for rs10069690 and rs2242652 were generated individually and in combination within the mini-gene. RT-PCR, using primers spanning intron 4, revealed that all SNP permutations in all cell-lines produced comparable levels of both wild-type and an INS1 alternative splice variant, which includes the first 38bp of <em>TERT</em> intron 4<sup><a href="#R46" class="usa-link" aria-describedby="R46">46</a>,<a href="#R47" class="usa-link" aria-describedby="R47">47</a></sup> (<a href="#SD1" class="usa-link">Supplementary Fig.5a</a>). We also identified a novel <em>TERT</em> splice variant, specifically associated with the minor allele of rs10069690 (termed INS1b; <a href="#SD1" class="usa-link">Supplementary Fig.5a</a>). Sequence analysis confirmed that INS1b includes the first 480bp of intron 4 and results from an alternative splice donor created by the minor allele of rs10069690<sup><a href="#R48" class="usa-link" aria-describedby="R48">48</a></sup>. INS1b has a premature stop codon 16 amino acids into intron 4 and is predicted to generate a severely truncated protein product, likely to impact on telomerase activity (<a href="#SD1" class="usa-link">Supplementary Fig.5b</a>).</p></section><section id="S12"><h4 class="pmc_sec_title">Gene expression and methylation analyses in ovarian tissue</h4> <p id="P17">We used The Cancer Genome Atlas (TCGA)<sup><a href="#R49" class="usa-link" aria-describedby="R49">49</a></sup> data to examine gene expression of the 11 protein-coding genes and one microRNA (<em>MIR4457</em>) located within 1Mb of Peak 3 SNP rs10069690. Most genes showed higher expression in ovarian tumors compared with normal tissues (<a href="#SD1" class="usa-link">Supplementary Fig.3; Supplementary Table 7</a>). We observed no association between rs10069690 and expression levels of any of the genes in any of the cells tested (<a href="#SD1" class="usa-link">Supplementary Table 7; Supplementary Table 8; Supplementary Fig.5</a>). There is some evidence of association between rs10069690 and tumor methylation with probes cg23827991 (<em>TERT</em> CpG island, <em>P</em>=1.3×10<sup>−6</sup>) and cg06550200 (<em>CLPTM1L</em>, <em>P</em>=6.9×10<sup>−4</sup>) among 935 probes tested. Both showed reduced methylation with the minor, cancer-risk allele (<a href="#SD1" class="usa-link">Supplementary Table 9</a>) but this did not correlate with changes in expression.</p></section></section></section><section id="S13"><h2 class="pmc_sec_title">Discussion</h2> <p id="P18">Our comprehensive examination of the <em>TERT</em> locus has answered some long-standing questions and raised several new ones. We have identified two independent regions associated with telomere length in leucocyte DNA; these provide definitive evidence for genetic control of telomere length by common <em>TERT</em> variants. For rs2736108, the most significant SNP in promoter Peak 1, the minor allele is associated with a 1.7%-fold increase in telomere length. This equates to a telomere length change of ~60bp and, since telomere length decreases by approximately 19bp per year of age<sup><a href="#R50" class="usa-link" aria-describedby="R50">50</a></sup>, this is equivalent in magnitude to an age difference of 3.1 years. We estimate that rs2736108 explains 0.08% of the variance in telomere length in men and 0.06% in women. SNPs in Peak 2 have a stronger effect on telomere length with each additional A (minor) allele of rs7705526 associated with a 2.6%-fold increase. This equates to a ~90bp change in telomere length and, correspondingly, to 4.7 years of age. We estimate that rs7705526 explains 0.31% of the variance in telomere length in men and 0.16% in women. The only other reported associations with telomere length, reaching genome-wide significance, involve <em>TERC</em>-locus SNP rs1269304<sup><a href="#R51" class="usa-link" aria-describedby="R51">51</a></sup> and <em>OBFC1</em>-locus SNP rs4387287<sup><a href="#R52" class="usa-link" aria-describedby="R52">52</a></sup>, which have similar effects on telomere length (75bp and 115bp per-allele, respectively).</p> <p id="P19">Our only findings consistent with the hypothesis that shorter telomeres predispose to increased cancer risk<sup><a href="#R53" class="usa-link" aria-describedby="R53">53</a></sup> (equivalent to longer telomeres being protective) are those from the Peak 1 SNPs. However, a regulatory-element construct containing the longer telomere associated alleles of three highly correlated SNPs, rs2736108, rs2736107 and rs2736109 (reconstructing a haplotype with 25% frequency in Europeans<sup><a href="#R35" class="usa-link" aria-describedby="R35">35</a></sup>) virtually abolished promoter activity in a reporter assay. This finding leaves an apparently paradoxical association between decreased enhancer activity and increased telomere length (<a href="#F4" class="usa-link">Figure 4</a>). Control of telomerase activity is currently poorly understood and this clearly merits further investigation.</p> <p id="P20">SNPs within Peak 3 (<em>TERT</em> introns 2–4) exhibit strong associations with hormone-related cancers: Peak 3 SNP rs10069690 is associated with risk of ER-negative breast cancer<sup><a href="#R34" class="usa-link" aria-describedby="R34">34</a></sup> and breast cancer in <em>BRCA1</em> mutation carriers, consistent with the observation that the majority of breast cancers arising in <em>BRCA1</em> mutation carriers are ER-negative. This variant has been reported to be associated with prostate cancer<sup><a href="#R26" class="usa-link" aria-describedby="R26">26</a>,<a href="#R54" class="usa-link" aria-describedby="R54">54</a></sup> and we find it associated with serous invasive ovarian cancer. Although SNPs in Peaks 2 and 3 overlap on a physical map, the SNPs most strongly associated with cancer risk or telomere length were not highly correlated with each other [r<sup>2</sup> between rs10069690 and rs7705526 = 0.33 (<a href="#F2" class="usa-link">Fig.2</a>, <strong>panel b</strong>)]. These observations suggest that either the associations observed with multiple cancers and SNPs in Peak 3 are mediated via a mechanism distinct from control of telomere length, or that telomere length in breast, prostate and ovarian cells is under the control of a different set of SNPs to those controlling telomere length in leucocytes. Luciferase reporter assays show that Peak 3 contains a silencer of the <em>TERT</em> promoter and that the minor allele of Peak 3 SNP rs2242652 further reduces expression. Consistent with this finding, Kote-Jarai Z. <em>et al</em>.<sup><a href="#R54" class="usa-link" aria-describedby="R54">54</a></sup>, report that the minor, risk allele of this SNP is associated with reduced <em>TERT</em> expression in benign prostate tissue. However, our search for comparable associations in ovarian or breast tumor tissue has been negative, possibly because <em>TERT</em> expression is severely disregulated in most tumors. Taken together, our luciferase assays indicate that either reduced signal from regulatory elements in Peaks 1 and 3, or increased signal from Peak 2, increases risk of specific cancer types.</p> <p id="P21">We have additionally shown that the minor allele of rs10069690 affects splicing and is associated with transcription of a novel, truncated isoform resulting from a premature stop codon (<a href="#SD1" class="usa-link">Supplementary Fig.4</a>). We do not yet know whether this isoform affects canonical telomerase activity, or how it changes activity. We further identified novel, open chromatin signatures overlapping rs10069690 in breast stromal and myoepithelial/stem cell fractions but not in progenitor or differentiated luminal epithelial cell fractions. Senescent stromal cells can stimulate malignant transformation of epithelial cells in <em>in vitro</em> and <em>in vivo</em> models<sup><a href="#R55" class="usa-link" aria-describedby="R55">55</a>,<a href="#R56" class="usa-link" aria-describedby="R56">56</a></sup>, and these SNP mechanisms merit investigation in future studies.</p> <p id="P22">The SNPs originally reported to be associated with risk of lung (rs402710)<sup><a href="#R57" class="usa-link" aria-describedby="R57">57</a></sup> and breast cancer (rs3816659)<sup><a href="#R58" class="usa-link" aria-describedby="R58">58</a></sup> (<a href="#SD1" class="usa-link">Supplementary Table 10</a>) were not associated with any cancer in this study. Moreover SNP rs2736100, in Peak 2, has been reported to be associated with glioma, lung and testicular cancer<sup><a href="#R27" class="usa-link" aria-describedby="R27">27</a>,<a href="#R28" class="usa-link" aria-describedby="R28">28</a>,<a href="#R31" class="usa-link" aria-describedby="R31">31</a>,<a href="#R57" class="usa-link" aria-describedby="R57">57</a>,<a href="#R59" class="usa-link" aria-describedby="R59">59</a>–<a href="#R62" class="usa-link" aria-describedby="R62">62</a></sup> while nearby SNP rs2853677 was reported to be associated with glioma in the Chinese Han population<sup><a href="#R63" class="usa-link" aria-describedby="R63">63</a></sup>. Despite their physical proximity, these are not highly correlated with rs7705526 (r<sup>2</sup>=0.52 and 0.18 respectively), nor do they display independent associations with telomere length after adjustment for rs7705526. Thus, variants underlying susceptibility to different cancer types are different from the set of variants in the <em>TERT</em> region mediating changes in telomere length.</p> <p id="P23">One limitation of this study is the incomplete representation of all SNPs at 5p15.33 on the iCOGS chip, which was designed in March 2010 using SNPs catalogued in HapMap3, together with those from the pilot study of the 1000GP<sup><a href="#R35" class="usa-link" aria-describedby="R35">35</a></sup>. To help fill known gaps on the iCOGS chip, additional SNPs were genotyped from the October 2010 1000GP data release, and imputation was based on the most recent, January 2012 release. However, several gaps remain across the <em>TERT</em> locus and this, coupled with the strikingly low linkage disequilibrium across the region (<a href="#F2" class="usa-link">Fig.2</a>), raises the possibility that there could be more independent associations that we have not yet detected. Furthermore, the incomplete SNP catalogue at the time of study design means that we cannot assume with certainty that the true causal variants, directly responsible for the observed association peaks, were captured in our analysis. It is also possible that more rare variants, not specifically investigated in this study, could have additional functional effects within this locus. Further re-sequencing of this region is needed to uncover the full spectrum of variation and phenotype associations. Another limitation is that telomere length was measured in DNA from leucocytes rather than from breast or ovarian tissue. Whilst we obtained suitable blood DNA for measurements in >53,000 subjects (a necessary sample size for adequate statistical power), obtaining comparable qualities and quantities of DNA from normal breast or ovary cells would be almost impossible. Telomere lengths, measured in different tissues within one individual have been shown to be highly correlated<sup><a href="#R64" class="usa-link" aria-describedby="R64">64</a>–<a href="#R66" class="usa-link" aria-describedby="R66">66</a></sup> meaning that leukocyte telomere lengths are likely to be good surrogates for other tissues. Furthermore, one of our aims was to investigate whether the previously reported associations between mean telomere length and cancer risk might be mediated through <em>TERT</em> variants, and such studies have been based on telomere length measured in blood cell DNA. Another limitation was that we were unable to stratify OCAC ovarian cancer cases by <em>BRCA1</em> and <em>BRCA2</em> mutation status because this information was not available; nor was there sufficient power to evaluate ovarian cancer risk in mutation carriers in CIMBA.</p> <p id="P24">Our findings provide evidence relevant to the hypothesis that shorter telomeres increase cancer risks: associations in the <em>TERT</em> promoter (Peak 1) fit this hypothesis best, while those in Peaks 2 and 3 (introns 2–4) and other reported 5p15.33 SNP-cancer associations (<a href="#SD1" class="usa-link">Supplementary Table 10</a>) do not. Thus, it would appear that the majority of cancer associations within the <em>TERT</em> locus are mediated via alternative mechanisms involving the <em>TERT</em> gene. The protein product of <em>TERT</em> has functions beyond the telomerase-mediated extension of telomeres<sup><a href="#R67" class="usa-link" aria-describedby="R67">67</a></sup>. These non-canonical functions of TERT strongly resemble those mediated by MYC and WNT<sup><a href="#R68" class="usa-link" aria-describedby="R68">68</a></sup>, which are upstream regulators of proliferation, differentiation and migration. TERT also modulates WNT/β-catenin signaling<sup><a href="#R69" class="usa-link" aria-describedby="R69">69</a></sup>, and ectopic TERT expression induces increased cell division and decreased apoptosis in primary mammary cells, independently of telomere elongation<sup><a href="#R70" class="usa-link" aria-describedby="R70">70</a></sup>.</p> <p id="P25">In conclusion, this study provides definitive evidence for genetic control of telomere length by common genetic variants in the <em>TERT</em> locus. Additionally, we report multiple, independent <em>TERT</em> SNP associations with breast cancer risk, confirming previously-reported associations and identifying new associations in both the general population and in <em>BRCA1</em> mutation carriers. We also provide, for the first time, highly significant evidence for the association of distinct <em>TERT</em> SNPs with serous LMP and invasive ovarian cancer risk. Our results demonstrate that the relationships between <em>TERT</em> genotype, telomere length and cancer risk are complex, and that the <em>TERT</em> locus may influence cancer risk through multiple mechanisms.</p></section><section id="S14"><h2 class="pmc_sec_title">Online Methods</h2> <section id="S15"><h3 class="pmc_sec_title">SNP selection and genotyping</h3> <p id="P26">Most SNPs were genotyped on the iCOGS custom array<sup><a href="#R36" class="usa-link" aria-describedby="R36">36</a>,<a href="#R37" class="usa-link" aria-describedby="R37">37</a>,<a href="#R71" class="usa-link" aria-describedby="R71">71</a></sup>. SNPs at 5p15.33 (Build 36 positions 1280000–1415000; Build 37 positions 1227693 to 1361969) were selected, based on published cancer associations, from the March 2010 release of the 1000 Genomes Project (1000GP)<sup><a href="#R35" class="usa-link" aria-describedby="R35">35</a></sup>. These included all known SNPs with minor allele frequency (MAF)>0.02 in Europeans and r<sup>2</sup>>0.1 with the then-known cancer associated SNPs (rs402710<sup><a href="#R57" class="usa-link" aria-describedby="R57">57</a></sup> and/or rs3816659<sup><a href="#R58" class="usa-link" aria-describedby="R58">58</a></sup>), plus a tagging set for all known SNPs in the linkage disequilibrium blocks encompassing the genes in the region (<em>SLC6A18</em>, <em>TERT</em> and <em>CLPTM1L</em>). An additional 30 SNPs in <em>TERT</em> were selected through a telomere length candidate gene approach. In total, 134 SNPs were selected, 121 of which were successfully manufactured; 110 of those passed quality control (QC)<sup><a href="#R36" class="usa-link" aria-describedby="R36">36</a></sup> in BCAC and CIMBA, and 108 in OCAC (<a href="#SD1" class="usa-link">Supplementary Tables 1–3</a>). After genotyping, these SNPs were complemented with 22 SNPs, selected from the October 2010 release of 1000GP, to improve coverage. These were genotyped in two BCAC studies, SEARCH<sup><a href="#R72" class="usa-link" aria-describedby="R72">72</a></sup> and CCHS<sup><a href="#R73" class="usa-link" aria-describedby="R73">73</a></sup>, using a Fluidigm™ array according to the manufacturer's instructions. To improve SNP density further, comprehensive genotype data for the locus were imputed for all subjects based on the January 2012 1000GP release. The genotype imputation process is described in<sup><a href="#R36" class="usa-link" aria-describedby="R36">36</a>–<a href="#R38" class="usa-link" aria-describedby="R38">38</a></sup>.</p></section><section id="S16"><h3 class="pmc_sec_title">Samples and Quality Control</h3> <p id="P27">Study characteristics, iCOGS methodology and quality control for cancer-risk analyses are detailed elsewhere<sup><a href="#R36" class="usa-link" aria-describedby="R36">36</a>–<a href="#R38" class="usa-link" aria-describedby="R38">38</a></sup>. We measured telomere length in 6,766 control samples from the SEARCH study; 1,569 of these were accrued by SEARCH itself<sup><a href="#R36" class="usa-link" aria-describedby="R36">36</a></sup>, 793 were collected as part of the Sisters in Breast Screening (SIBS) study<sup><a href="#R15" class="usa-link" aria-describedby="R15">15</a></sup> and 4,404 were cancer-free participants in the EPIC-Norfolk study<sup><a href="#R19" class="usa-link" aria-describedby="R19">19</a></sup>. We also measured telomere length in 8,841 participants in the Copenhagen City Heart Study (CCHS)<sup><a href="#R73" class="usa-link" aria-describedby="R73">73</a>,<a href="#R74" class="usa-link" aria-describedby="R74">74</a></sup> and in 38,145 participants in the Copenhagen General Population Study (CGPS)<sup><a href="#R75" class="usa-link" aria-describedby="R75">75</a>,<a href="#R76" class="usa-link" aria-describedby="R76">76</a></sup>. Genotype clusters were visually inspected for the most strongly associated SNPs (<a href="#SD1" class="usa-link">Supplementary Fig.6</a>). For all studies, ethnicity was assigned using HapMap (release 22) genotype data for European, African and Asian populations as reference (for BCAC and CIMBA using multidimensional scaling, for OCAC using LAMP<sup><a href="#R77" class="usa-link" aria-describedby="R77">77</a></sup>). All CIMBA analyses were restricted to individuals of European ancestry. For BCAC, separate estimates for individuals of East Asian and African-American ancestry were also derived. For OCAC, limited analyses of non-European ancestry groups were also performed. A subset of BCAC and OCAC were utilised in previous breast and ovarian cancer association studies of individual SNPs<sup><a href="#R78" class="usa-link" aria-describedby="R78">78</a></sup>. However, the associations with the key SNPs (rs10069690, rs2736108 and rs7705526) remained significant after excluding these studies, demonstrating similar ORs.</p></section><section id="S17"><h3 class="pmc_sec_title">Telomere length measurement</h3> <p id="P28">Telomere length was measured in SEARCH using a modified version of the protocol as described elsewhere<sup><a href="#R19" class="usa-link" aria-describedby="R19">19</a>,<a href="#R79" class="usa-link" aria-describedby="R79">79</a></sup>. Twelve percent of samples were run in duplicate. Failed PCR reactions were not repeated. Telomere length was measured in CCHS and CGPS with a modified version of the protocol as described elsewhere<sup><a href="#R50" class="usa-link" aria-describedby="R50">50</a>,<a href="#R80" class="usa-link" aria-describedby="R80">80</a></sup>. Each individual was measured in quadruplicate. After exclusion of outliers, average cycle threshold (Ct) values of the remaining samples were calculated. Failed measurements were repeated up to twice. For meta-analysis, telomere length measurements from SEARCH were converted to the same scale as the CCHS and CGPS measurements, based on parameters from the linear regression between corresponding CCHS and SEARCH 10-year-age and 5-percentile groups in women only (<a href="#SD1" class="usa-link">Supplementary Fig.7</a>). This measure of telomere length was used for all the analyses and then converted into fold changes (RTL) to aid interpretation (<a href="#SD1" class="usa-link">Supplementary Fig.7</a>).</p></section><section id="S18"><h3 class="pmc_sec_title">Statistical analyses</h3> <p id="P29">SNP associations with telomere length were evaluated using linear regression to model the fold-change in telomere length per-minor-allele, adjusted for age, 384-well plate, sex, seven principal components and study. The SNP was coded as number of minor alleles (0, 1, 2 for genotyped and the inferred genotype for imputed SNPs). The test of association was based on the 1 degree of freedom (1<em>df</em>) trend-test statistic. We also performed separate analyses (SEARCH, CCHS females, CCHS males, CGPS females, CGPS males) and combined the parameter estimates in a fixed-effect meta-analysis<sup><a href="#R81" class="usa-link" aria-describedby="R81">81</a></sup>. Associations with breast and ovarian cancer risk in BCAC and OCAC were evaluated by comparing genotype frequencies in cases and controls using unconditional logistic regression. Analyses were adjusted for study and seven principal components in BCAC<sup><a href="#R36" class="usa-link" aria-describedby="R36">36</a></sup> and five in OCAC<sup><a href="#R37" class="usa-link" aria-describedby="R37">37</a></sup>. Nine OCAC studies with case-only genotype data were paired with case-control studies from similar geographic regions, resulting in 34 analysis study-strata. The principal analysis fitted the SNP as an allelic dose and tested for association using a 1<em>df</em> trend-test, but genotype-specific risks were also obtained. Associations between genotypes and breast cancer risk in CIMBA studies (<em>BRCA1</em> carriers) were evaluated using a 1<em>df</em> per-allele trend-score test, based on modeling the retrospective likelihood of the observed genotypes conditional on breast cancer phenotypes<sup><a href="#R82" class="usa-link" aria-describedby="R82">82</a></sup>. To allow for non-independence among related individuals, an adjusted version of the score-test was used in which the variance of the score was derived, taking into account the correlation between the genotypes by estimating the kinship coefficient for each pair of individuals using the available genotype data<sup><a href="#R83" class="usa-link" aria-describedby="R83">83</a></sup>. Per-allele Hazard Ratio (HR) estimates were obtained by maximizing the retrospective likelihood. All analyses were stratified by country of residence. USA and Canada strata were further stratified on the basis of reported Ashkenazi Jewish ancestry.</p> <p id="P30">Conditional analyses were performed to identify SNPs independently associated with each phenotype. To identify the most parsimonious model, all SNPs with marginal <em>P</em>-value<0.001 were included in forward-selection regression analyses with a threshold for inclusion of <em>P</em>-value<10<sup>−4</sup>, and including terms for age (for telomere length only), principal components and study. Similarly, forward-selection Cox-regression analysis was performed for <em>BRCA1</em> carriers, stratified by country of residence, using the same <em>P</em>-value thresholds. This approach provides valid association tests, although the estimates can be biased<sup><a href="#R82" class="usa-link" aria-describedby="R82">82</a>,<a href="#R84" class="usa-link" aria-describedby="R84">84</a></sup>. Parameter estimates for the most parsimonious model were obtained using the retrospective likelihood approach.</p></section><section id="S19"><h3 class="pmc_sec_title">FACS-sorting</h3> <p id="P31">Normal breast tissue was donated by women undergoing reduction mammoplasty surgery. Patients provided written consent and all work was performed with full local institutional human ethics approval. Tissue was dissociated as described previously<sup><a href="#R85" class="usa-link" aria-describedby="R85">85</a></sup>. Cells were prepared for flow cytometry as described previously<sup><a href="#R42" class="usa-link" aria-describedby="R42">42</a></sup> by staining with a cocktail of Lin+ markers (CD31-PE, CD45-PE and CD235a-PE), EpCAM-FITC, CD49f-PE-Cy5 and Sytox Blue. Cells were then processed by a BD FACSAria II Cell Sorter and live cells immuno-negative for Lin+ markers were sorted into four subpopulations on the basis of their EpCAM-FITC and CD49f-PE-Cy5 fluorescence.</p></section><section id="S20"><h3 class="pmc_sec_title">FAIRE analysis</h3> <p id="P32">Cell pellets derived from FACS-sorting of breast tissue samples were cross-linked in 1% formaldehyde, then lysed in 200μl Tris-buffered 1% SDS lysis buffer containing protease inhibitors. Lysates were sonicated using a QSONICA Model Q125 Ultra Sonic Processor to shear chromatin to 200bp-1kb fragments. Insoluble cell material was removed through centrifugation, and supernatants equally divided into 100μl INPUT and FAIRE samples. INPUTs were incubated overnight at 65°C to reverse cross-linking. All samples were purified through two rounds of phenol-chloroform extraction and DNA recovered through ethanol precipitation and re-suspended in water for use as PCR templates.</p></section><section id="S21"><h3 class="pmc_sec_title">Plasmid construction and luciferase assays</h3> <p id="P33"><em>TERT</em> promoter variants were introduced into pGL3-TERT-3915<sup><a href="#R43" class="usa-link" aria-describedby="R43">43</a></sup> by site-directed mutagenesis (Agilent Technologies). <em>TERT</em> Putative Regulatory Elements PRE-A (hg19; chr5:1,284,900–1,287,087) and PRE-B (chr5:1,279,401–1,282,763), were PCR amplified using KAPAHiFi DNA polymerase (Geneworks) and cloned into pGL3-TERT-3915 or rs2736107/8/9 vectors. Individual SNPs were incorporated using overlap extension PCR. Cells were transfected with equimolar amounts of luciferase reporter plasmids and 50ng of pRLTK using siPORT NeoFX Transfection Agent (Ambion), according to the manufacturer's instructions, and harvested after 48h. Luminescence was measured with a Wallac Victor3 1420 multilabel counter and data (n=3) was analysed by one-way ANOVA with post-hoc Dunnett's tests.</p></section><section id="S22"><h3 class="pmc_sec_title">Mini-gene construction and qRT-PCR analysis</h3> <p id="P34"><em>TERT</em> intron 4 was synthesised by GenScript and subcloned into pIRES-TERT<sup><a href="#R44" class="usa-link" aria-describedby="R44">44</a></sup>. The minor alleles at rs10069690 and rs2242652 were introduced by site-directed mutagenesis (Agilent Technologies). The resultant plasmids, designated pIRES-TERTint4-WT (wild-type intron 4), pIRES-TERTint4-rs10069690, pIRES-TERTint4-rs2242652 and pIRES-TERTint4-DM (minor alleles at both sites), were transfected using siPORT <em>NeoFX</em> Transfection Agent (Ambion) and cells harvested after 24h. Total RNA was extracted using the RNeasy Mini Kit (Qiagen) and digested with DNaseI (Invitrogen). cDNA was synthesised from 1μg RNA by random priming using SuperScript III reverse transcriptase (Invitrogen). Samples were screened for the presence of <em>TERT</em> splice variants by RT-PCR.</p></section><section id="S23"><h3 class="pmc_sec_title">Molecular correlations at the 5p15.33 locus</h3> <p id="P35">For each gene within 1Mb we performed the following assays: (1) gene expression analysis in ovarian cancer cell lines (N=50) compared to ovarian surface epithelial and fallopian tube secretory cell lines (N=73) and tissues from high-grade serous ovarian cancers; (2) methylation analysis in high-grade serous ovarian cancers compared to normal tissues, and methylation quantitative trait locus (mQTL) analysis; (3) expression quantitative trait locus (eQTL) analysis to evaluate genotype-gene expression associations in normal high-grade serous ovarian cancers precursor tissues. We also evaluated these genes <em>in silico</em> in the somatic data from The Cancer Genome Atlas (TCGA<sup><a href="#R49" class="usa-link" aria-describedby="R49">49</a></sup>). We also profiled the spectrum of non-coding regulatory elements in ovarian surface epithelial and fallopian tube secretory cell lines using a combination of formaldehyde-assisted isolation of regulatory elements sequencing (FAIRE-seq<sup><a href="#R40" class="usa-link" aria-describedby="R40">40</a></sup>) and RNA sequencing (RNA-seq).</p></section></section><section id="SM"><h2 class="pmc_sec_title">Supplementary Material</h2> <section class="sm xbox font-sm" id="SD1"><div class="caption p"><span>Part 1</span></div> <div class="media p" id="d36e6327"><div class="caption"> <a href="/articles/instance/3670748/bin/NIHMS467552-supplement-Part_1.doc" data-ga-action="click_feat_suppl" class="usa-link">NIHMS467552-supplement-Part_1.doc</a><sup> (9.5MB, doc) </sup> </div></div></section><section class="sm xbox font-sm" id="SD2"><div class="caption p"><span>Part 2</span></div> <div class="media p" id="d36e6331"><div class="caption"> <a href="/articles/instance/3670748/bin/NIHMS467552-supplement-Part_2.doc" data-ga-action="click_feat_suppl" class="usa-link">NIHMS467552-supplement-Part_2.doc</a><sup> (62KB, doc) </sup> </div></div></section></section><section id="S24" class="ack"><h2 class="pmc_sec_title">Acknowledgements</h2> <p>COGS is funded through a European Commission's Seventh Framework Programme grant (agreement number 223175 - HEALTH-F2-2009-223175). BCAC is funded by CR-UK (C1287/A10118 and C1287/A12014). BCAC meetings have been funded by the European Union COST programme (BM0606). Telomere length measurement and analysis was funded by CR-UK project grant C1287/A9540 and Chief Physician Johan Boserup and Lise Boserup's Fund. CIMBA data management and analysis were supported by Cancer Research – UK grants C12292/A11174 and C1287/A10118. OCAC is supported by a grant from the Ovarian Cancer Research Fund thanks to the family and friends of Kathryn Sladek Smith (PPD/RPCI.07). Genotyping of the iCOGS array was funded by the European Union (HEALTH-F2-2009-223175), Cancer Research UK (C1287/A10710), the Canadian Institutes of Health Research for the “CIHR Team in Familial Risks of Breast Cancer” program (J.S. & D.E.), and the Ministry of Economic Development, Innovation and Export Trade of Quebec – grant # PSR-SIIRI-701 (J.S. & D.E, P.Hall). Scientific development and funding of the OCAC portion of this project were supported by the Genetic Associations and Mechanisms in Oncology (GAME-ON; U19-CA148112). CIMBA genotyping was supported by NIH grant CA128978, an NCI Specialized Program of Research Excellence (SPORE) in Breast Cancer (CA116201), a U.S. Department of Defense Ovarian Cancer Idea award (W81XWH-10-1-0341), grants from the Breast Cancer Research Foundation and the Komen Foundation for the Cure. This study made use of data generated by: The Wellcome Trust Case Control Consortium (A full list of WTCCC investigators is available from <a href="http://www.wtccc.org.uk/" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">http://www.wtccc.org.uk/</a>; funding was provided by Wellcome Trust award 076113) and The Cancer Genome Atlas (TCGA) Pilot Project established by the National Cancer Institute and National Human Genome Research Institute (The investigators and institutions constituting the TCGA research network, can be found at <a href="http://cancergenome.nih.gov/" class="usa-link" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">http://cancergenome.nih.gov/</a>.)</p> <p>We thank all the individuals who took part in these studies and all the researchers, clinicians, technicians and administrative staff who have enabled this work to be carried out.</p></section><section id="fn-group1" class="fn-group"><h2 class="pmc_sec_title">Footnotes</h2> <div class="fn-group p font-secondary-light font-sm"><div class="fn p" id="FN3"> <p id="P36"><strong>URLs </strong><em>TERT</em> gene, <a href="http://www.ncbi.nlm.nih.gov/gene/7015" class="usa-link" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">http://www.ncbi.nlm.nih.gov/gene/7015</a>.</p> <p id="P37">HapMap3 catalogue, <a href="http://www.sanger.ac.uk/resources/downloads/human/hapmap3.html" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">http://www.sanger.ac.uk/resources/downloads/human/hapmap3.html</a>.</p> </div></div></section><section id="ref-list1" class="ref-list"><h2 class="pmc_sec_title">References</h2> <section id="ref-list1_sec2"><ul class="ref-list font-sm" style="list-style-type:none"> <li id="R1"> <span class="label">1.</span><cite>McEachern MJ, Krauskopf A, Blackburn EH. 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