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class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="57388409" href="https://www.academia.edu/Documents/in/Pediatric_Neurology"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/ElenaKvan","location":"/ElenaKvan","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/ElenaKvan","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Pediatric Neurology"]}" data-trace="false" data-dom-id="Pill-react-component-0d5a6239-79a6-4263-bfad-93237bcfcb89"></div> <div id="Pill-react-component-0d5a6239-79a6-4263-bfad-93237bcfcb89"></div> </a><a 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class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Elena Kvan</h3></div><div class="js-work-strip profile--work_container" data-work-id="96162660"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96162660/P_piller_med_forlenget_syklus_et_fremskritt"><img alt="Research paper thumbnail of P-piller med forlenget syklus – et fremskritt?" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96162660/P_piller_med_forlenget_syklus_et_fremskritt">P-piller med forlenget syklus – et fremskritt?</a></div><div class="wp-workCard_item"><span>Tidsskrift for Den Norske Laegeforening</span><span>, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96162660"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192880"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192880/High_mortality_in_diabetic_patients_with_acute_myocardial_infarction_Cardiovascular_co_morbidities_contribute_most_to_the_high_risk"><img alt="Research paper thumbnail of High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk" class="work-thumbnail" src="https://attachments.academia-assets.com/50652437/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192880/High_mortality_in_diabetic_patients_with_acute_myocardial_infarction_Cardiovascular_co_morbidities_contribute_most_to_the_high_risk">High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk</a></div><div class="wp-workCard_item"><span>International Journal of Cardiology</span><span>, Oct 1, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9c853fcab328f52d530e5bf70876deb0" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50652437,"asset_id":30192880,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50652437/download_file?st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192880"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192880"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192880; 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The excess mortality has been attributed to the diabetic state itself. We aimed to investigate how other risk factors along with diabetes per se may predict mortality in an unselected AMI population. Methods: A representative sample of an unselected AMI population was collected over a three-month period. Data on patients' histories, comorbidity, presenting features and treatment were collected from medical records. The data sets included outcome variables at discharge, after 6 months and after 2.5 years. Patients with confirmed diabetes on admission to hospital were registered as diabetic patients. Results: Of the 901 patients admitted to hospital with AMI, 121 (14%) were diabetic patients. Compared with the nondiabetic patients significantly fewer of the diabetic patients were alive at discharge (78% vs 86%), after 6 months (64% vs 78%) and after 2.5 years (42% vs 65%). In multiple logistic regression analyses adjusted for age, sex and smoking status, the most important predictor of death at 2.5 years was heart failure, followed by previous MI, diabetes, and angina pectoris. The population attributable risk (PAR) of death after 2.5 years was 7% for diabetes, 17% for previous MI, 13% for heart failure and 12% for angina pectoris. 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192878/_Sex_differences_and_cardiovascular_drugs_">[Sex differences and cardiovascular drugs]</a></div><div class="wp-workCard_item"><span>Tidsskrift for den Norske laegeforening</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the western world, cardiovascular disease is the leading cause of death for both sexes. These ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the western world, cardiovascular disease is the leading cause of death for both sexes. These diseases show substantial differences between the sexes with respect to epidemiology, biology and clinical aspects. In recent years, more attention has been directed towards sex differences in pharmacological effects. Although both sexes are included in most pharmacological trials, the proportion of women is often too low to enable sex-specific analyses.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192878]").text(description); $(".js-view-count[data-work-id=30192878]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192878']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192878, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192878]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192878,"title":"[Sex differences and cardiovascular drugs]","translated_title":"","metadata":{"abstract":"In the western world, cardiovascular disease is the leading cause of death for both sexes. 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These ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the western world, cardiovascular disease is the leading cause of death for both sexes. These diseases show substantial differences between the sexes with respect to epidemiology, biology and clinical aspects. In recent years, more attention has been directed towards sex differences in pharmacological effects. Although both sexes are included in most pharmacological trials, the proportion of women is often too low to enable sex-specific analyses.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192877"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192877"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192877; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192877]").text(description); $(".js-view-count[data-work-id=30192877]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192877; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192877']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192877, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192877]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192877,"title":"[Sex differences and cardiovascular drugs]","translated_title":"","metadata":{"abstract":"In the western world, cardiovascular disease is the leading cause of death for both sexes. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192876"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192876/_Long_cycle_oral_contraceptives_a_progress_"><img alt="Research paper thumbnail of [Long-cycle oral contraceptives--a progress?]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192876/_Long_cycle_oral_contraceptives_a_progress_">[Long-cycle oral contraceptives--a progress?]</a></div><div class="wp-workCard_item"><span>Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række</span><span>, Jan 25, 2005</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192876"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192876"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192876; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192876]").text(description); $(".js-view-count[data-work-id=30192876]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192876; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192876']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192876, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192876]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192876,"title":"[Long-cycle oral contraceptives--a progress?]","translated_title":"","metadata":{"publication_date":{"day":25,"month":1,"year":2005,"errors":{}},"publication_name":"Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række"},"translated_abstract":null,"internal_url":"https://www.academia.edu/30192876/_Long_cycle_oral_contraceptives_a_progress_","translated_internal_url":"","created_at":"2016-12-01T00:31:02.273-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Long_cycle_oral_contraceptives_a_progress_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":16038,"name":"Menstruation","url":"https://www.academia.edu/Documents/in/Menstruation"},{"id":182850,"name":"Menstrual Cycle","url":"https://www.academia.edu/Documents/in/Menstrual_Cycle"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192875"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192875/Use_of_cardiovascular_drugs_after_acute_myocardial_infarction_a_marked_shift_towards_evidence_based_drug_therapy"><img alt="Research paper thumbnail of Use of cardiovascular drugs after acute myocardial infarction: a marked shift towards evidence-based drug therapy" class="work-thumbnail" src="https://attachments.academia-assets.com/50652436/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192875/Use_of_cardiovascular_drugs_after_acute_myocardial_infarction_a_marked_shift_towards_evidence_based_drug_therapy">Use of cardiovascular drugs after acute myocardial infarction: a marked shift towards evidence-based drug therapy</a></div><div class="wp-workCard_item"><span>Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To investigate the prescription pattern for cardiovascular drugs among patients discharged after ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To investigate the prescription pattern for cardiovascular drugs among patients discharged after an acute myocardial infarction (AMI) in hospitals that had participated in a corresponding study seven years earlier, and examine what the indications were for use of the different drugs. From 16 hospitals we drew a sample of patients who were discharged with a diagnosis of AMI during a three months period in 1999/2000. Physicians in each hospital obtained from the medical records the observed rate of use of cardiovascular drugs at discharge. The drug use was compared with findings from a corresponding sample drawn in 1993. The main indication for use of the different cardiovascular drugs was recorded for the 1999/2000 sample. 399 patients discharged alive were included in the first study and 767 in the second. The use of beta-blockers, ACE inhibitors and statins rose substantially during the period. For patients aged &lt;/=70 drug use in respectively 1993 and 1999/2000 was as follows: b...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e83e8720d61e31468d8ce47b7ea23cc6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50652436,"asset_id":30192875,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50652436/download_file?st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192875"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192875"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192875; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192875]").text(description); $(".js-view-count[data-work-id=30192875]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192875; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192875']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192875, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "e83e8720d61e31468d8ce47b7ea23cc6" } } $('.js-work-strip[data-work-id=30192875]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192875,"title":"Use of cardiovascular drugs after acute myocardial infarction: a marked shift towards evidence-based drug therapy","translated_title":"","metadata":{"abstract":"To investigate the prescription pattern for cardiovascular drugs among patients discharged after an acute myocardial infarction (AMI) in hospitals that had participated in a corresponding study seven years earlier, and examine what the indications were for use of the different drugs. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192874"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192874/RAS_hemmere_og_infarktst%C3%B8rrelse"><img alt="Research paper thumbnail of RAS-hemmere og infarktstørrelse" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192874/RAS_hemmere_og_infarktst%C3%B8rrelse">RAS-hemmere og infarktstørrelse</a></div><div class="wp-workCard_item"><span>Tidsskrift for Den norske legeforening</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192874"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192874"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192874; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192874]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192874,"title":"RAS-hemmere og infarktstørrelse","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Tidsskrift for Den norske legeforening"},"translated_abstract":null,"internal_url":"https://www.academia.edu/30192874/RAS_hemmere_og_infarktst%C3%B8rrelse","translated_internal_url":"","created_at":"2016-12-01T00:31:02.037-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"RAS_hemmere_og_infarktstørrelse","translated_slug":"","page_count":null,"language":"da","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":71399,"name":"Hypertension","url":"https://www.academia.edu/Documents/in/Hypertension"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192873"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192873/Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function"><img alt="Research paper thumbnail of Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192873/Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function">Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function</a></div><div class="wp-workCard_item"><span>Scandinavian Cardiovascular Journal</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To investigate to what extent and by what methods clinicians assess left ventricular (LV) functio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To investigate to what extent and by what methods clinicians assess left ventricular (LV) function after an acute myocardial infarction (AMI) and how the results of the assessments relate to the use of angiotensin-converting enzyme (ACE) inhibitors; furthermore, to explore which main indications caused the clinicians to initiate ACE inhibitor therapy. From 16 hospitals we drew a sample of patients who were discharged with the diagnosis of AMI during a 3-month period in 1999/2000. Physicians in each hospital obtained the observed rate of use of cardiovascular drugs at discharge and also information on ejection fraction (EF) measurements. The results of the EF recordings were classified into three categories: &amp;amp;amp;amp;amp;gt;0.50, 0.40-0.50 and &amp;amp;amp;amp;amp;lt;0.40. The clinicians&amp;amp;amp;amp;amp;#39; main indications for drug use were reported. Among 767 patients discharged alive, EF was measured in 409 (53%), by echocardiography in 53% and by radionuclide ventriculography in 47%. Of the 409 patients 227 (55%) had EF &amp;amp;amp;amp;amp;gt;0.50, 95 (24%) EF 0.40-0.50 and 87 (21%) EF &amp;amp;amp;amp;amp;lt;0.40. Adjusted odds ratio for ACE inhibitor therapy being initiated during the AMI was 13.5 for those with EF &amp;amp;amp;amp;amp;lt;0.40 compared with those with EF &amp;amp;amp;amp;amp;gt;0.50. The main indication for starting ACE inhibitor therapy was heart failure (50%) followed by secondary prevention (42%). Measuring EF appears to be an important tool in the evaluation of AMI patients prior to discharge from hospital. Initiation of ACE inhibitor therapy related strongly to the results of the assessments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192873"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192873"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192873; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192873]").text(description); $(".js-view-count[data-work-id=30192873]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192873; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192873']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192873, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192873]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192873,"title":"Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function","translated_title":"","metadata":{"abstract":"To investigate to what extent and by what methods clinicians assess left ventricular (LV) function after an acute myocardial infarction (AMI) and how the results of the assessments relate to the use of angiotensin-converting enzyme (ACE) inhibitors; furthermore, to explore which main indications caused the clinicians to initiate ACE inhibitor therapy. From 16 hospitals we drew a sample of patients who were discharged with the diagnosis of AMI during a 3-month period in 1999/2000. Physicians in each hospital obtained the observed rate of use of cardiovascular drugs at discharge and also information on ejection fraction (EF) measurements. The results of the EF recordings were classified into three categories: \u0026amp;amp;amp;amp;amp;gt;0.50, 0.40-0.50 and \u0026amp;amp;amp;amp;amp;lt;0.40. The clinicians\u0026amp;amp;amp;amp;amp;#39; main indications for drug use were reported. Among 767 patients discharged alive, EF was measured in 409 (53%), by echocardiography in 53% and by radionuclide ventriculography in 47%. Of the 409 patients 227 (55%) had EF \u0026amp;amp;amp;amp;amp;gt;0.50, 95 (24%) EF 0.40-0.50 and 87 (21%) EF \u0026amp;amp;amp;amp;amp;lt;0.40. Adjusted odds ratio for ACE inhibitor therapy being initiated during the AMI was 13.5 for those with EF \u0026amp;amp;amp;amp;amp;lt;0.40 compared with those with EF \u0026amp;amp;amp;amp;amp;gt;0.50. The main indication for starting ACE inhibitor therapy was heart failure (50%) followed by secondary prevention (42%). Measuring EF appears to be an important tool in the evaluation of AMI patients prior to discharge from hospital. Initiation of ACE inhibitor therapy related strongly to the results of the assessments.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Scandinavian Cardiovascular Journal"},"translated_abstract":"To investigate to what extent and by what methods clinicians assess left ventricular (LV) function after an acute myocardial infarction (AMI) and how the results of the assessments relate to the use of angiotensin-converting enzyme (ACE) inhibitors; furthermore, to explore which main indications caused the clinicians to initiate ACE inhibitor therapy. From 16 hospitals we drew a sample of patients who were discharged with the diagnosis of AMI during a 3-month period in 1999/2000. Physicians in each hospital obtained the observed rate of use of cardiovascular drugs at discharge and also information on ejection fraction (EF) measurements. The results of the EF recordings were classified into three categories: \u0026amp;amp;amp;amp;amp;gt;0.50, 0.40-0.50 and \u0026amp;amp;amp;amp;amp;lt;0.40. The clinicians\u0026amp;amp;amp;amp;amp;#39; main indications for drug use were reported. Among 767 patients discharged alive, EF was measured in 409 (53%), by echocardiography in 53% and by radionuclide ventriculography in 47%. Of the 409 patients 227 (55%) had EF \u0026amp;amp;amp;amp;amp;gt;0.50, 95 (24%) EF 0.40-0.50 and 87 (21%) EF \u0026amp;amp;amp;amp;amp;lt;0.40. Adjusted odds ratio for ACE inhibitor therapy being initiated during the AMI was 13.5 for those with EF \u0026amp;amp;amp;amp;amp;lt;0.40 compared with those with EF \u0026amp;amp;amp;amp;amp;gt;0.50. The main indication for starting ACE inhibitor therapy was heart failure (50%) followed by secondary prevention (42%). Measuring EF appears to be an important tool in the evaluation of AMI patients prior to discharge from hospital. Initiation of ACE inhibitor therapy related strongly to the results of the assessments.","internal_url":"https://www.academia.edu/30192873/Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function","translated_internal_url":"","created_at":"2016-12-01T00:31:01.933-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability"},{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway"},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics"},{"id":100657,"name":"Therapy","url":"https://www.academia.edu/Documents/in/Therapy"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals"},{"id":198747,"name":"Left Ventricular Dysfunction","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Dysfunction"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis"},{"id":719604,"name":"Angiotensin Converting Enzyme","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme"},{"id":918981,"name":"Left Ventricular Function","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Function"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models"},{"id":1425542,"name":"ACE Inhibitor","url":"https://www.academia.edu/Documents/in/ACE_Inhibitor"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192872"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192872/Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention"><img alt="Research paper thumbnail of Treatment with statins after acute myocardial infarction in patients ≥80 years: underuse despite general acceptance of drug therapy for secondary prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192872/Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention">Treatment with statins after acute myocardial infarction in patients ≥80 years: underuse despite general acceptance of drug therapy for secondary prevention</a></div><div class="wp-workCard_item"><span>Pharmacoepidemiology and Drug Safety</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It has not been decided to what extent the results from statin trials should be transferred to cl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It has not been decided to what extent the results from statin trials should be transferred to clinical practice in the very old. The aim of the study was to assess the use of cardiovascular drugs after an acute myocardial infarction (MI), with particular focus on statins, in very old patients as compared to younger patients. A sample of 901 acute MI patients was drawn from 16 hospitals in 1999/2000; the patients were followed up for 2.5 years. Information on demographic variables and drug therapy was obtained from hospital records, and in the follow-up period by direct patient contact or questionnaire. The main indications for prescribing the various cardiovascular drugs were recorded. At discharge, drug use in patients &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years, respectively, was as follows: ACE-inhibitors 48 versus 32%, nitrates 55 versus 32%, diuretics 64 versus 26%, aspirin 72 versus 86%, and beta-blockers 67 versus 85%. A striking difference was found for statins: 9% in the very old and 72% in younger patients. The pattern of drug use generally remained unchanged after 2.5 years. Survival rates for patients &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years: at discharge 72 versus 90%, after 2.5 years 34 versus 73%. Drug therapy was widely accepted for the indication secondary prevention after MI in patients above 80 years of age. The various cardiovascular drugs were prescribed to about the same extent for very old and younger patients. The exception was lipid lowering drugs which, despite the physicians&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; recognition of the indication secondary prevention in the very old patients, were prescribed to a limited extent.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192872"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192872"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192872; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192872]").text(description); $(".js-view-count[data-work-id=30192872]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192872; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192872']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192872, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192872]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192872,"title":"Treatment with statins after acute myocardial infarction in patients ≥80 years: underuse despite general acceptance of drug therapy for secondary prevention","translated_title":"","metadata":{"abstract":"It has not been decided to what extent the results from statin trials should be transferred to clinical practice in the very old. The aim of the study was to assess the use of cardiovascular drugs after an acute myocardial infarction (MI), with particular focus on statins, in very old patients as compared to younger patients. A sample of 901 acute MI patients was drawn from 16 hospitals in 1999/2000; the patients were followed up for 2.5 years. Information on demographic variables and drug therapy was obtained from hospital records, and in the follow-up period by direct patient contact or questionnaire. The main indications for prescribing the various cardiovascular drugs were recorded. At discharge, drug use in patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years, respectively, was as follows: ACE-inhibitors 48 versus 32%, nitrates 55 versus 32%, diuretics 64 versus 26%, aspirin 72 versus 86%, and beta-blockers 67 versus 85%. A striking difference was found for statins: 9% in the very old and 72% in younger patients. The pattern of drug use generally remained unchanged after 2.5 years. Survival rates for patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years: at discharge 72 versus 90%, after 2.5 years 34 versus 73%. Drug therapy was widely accepted for the indication secondary prevention after MI in patients above 80 years of age. The various cardiovascular drugs were prescribed to about the same extent for very old and younger patients. The exception was lipid lowering drugs which, despite the physicians\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; recognition of the indication secondary prevention in the very old patients, were prescribed to a limited extent.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Pharmacoepidemiology and Drug Safety"},"translated_abstract":"It has not been decided to what extent the results from statin trials should be transferred to clinical practice in the very old. The aim of the study was to assess the use of cardiovascular drugs after an acute myocardial infarction (MI), with particular focus on statins, in very old patients as compared to younger patients. A sample of 901 acute MI patients was drawn from 16 hospitals in 1999/2000; the patients were followed up for 2.5 years. Information on demographic variables and drug therapy was obtained from hospital records, and in the follow-up period by direct patient contact or questionnaire. The main indications for prescribing the various cardiovascular drugs were recorded. At discharge, drug use in patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years, respectively, was as follows: ACE-inhibitors 48 versus 32%, nitrates 55 versus 32%, diuretics 64 versus 26%, aspirin 72 versus 86%, and beta-blockers 67 versus 85%. A striking difference was found for statins: 9% in the very old and 72% in younger patients. The pattern of drug use generally remained unchanged after 2.5 years. Survival rates for patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years: at discharge 72 versus 90%, after 2.5 years 34 versus 73%. Drug therapy was widely accepted for the indication secondary prevention after MI in patients above 80 years of age. The various cardiovascular drugs were prescribed to about the same extent for very old and younger patients. The exception was lipid lowering drugs which, despite the physicians\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; recognition of the indication secondary prevention in the very old patients, were prescribed to a limited extent.","internal_url":"https://www.academia.edu/30192872/Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention","translated_internal_url":"","created_at":"2016-12-01T00:31:01.836-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis"},{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway"},{"id":66080,"name":"Age","url":"https://www.academia.edu/Documents/in/Age"},{"id":172151,"name":"Acute Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Acute_Myocardial_Infarction"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":555323,"name":"Drug Therapy","url":"https://www.academia.edu/Documents/in/Drug_Therapy"},{"id":874382,"name":"Medical Records","url":"https://www.academia.edu/Documents/in/Medical_Records"},{"id":1200766,"name":"Drug Utilization","url":"https://www.academia.edu/Documents/in/Drug_Utilization"},{"id":1246554,"name":"SECONDARY PREVENTION","url":"https://www.academia.edu/Documents/in/SECONDARY_PREVENTION"},{"id":1698107,"name":"Pharmacoepidemiology and drug safety","url":"https://www.academia.edu/Documents/in/Pharmacoepidemiology_and_drug_safety"},{"id":2060696,"name":"Health services for the aged","url":"https://www.academia.edu/Documents/in/Health_services_for_the_aged"},{"id":2491318,"name":"Guideline Adherence","url":"https://www.academia.edu/Documents/in/Guideline_Adherence"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192871"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192871/High_mortality_in_diabetic_patients_with_acute_myocardial_infarction_Cardiovascular_co_morbidities_contribute_most_to_the_high_risk"><img alt="Research paper thumbnail of High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk" class="work-thumbnail" src="https://attachments.academia-assets.com/50652433/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192871/High_mortality_in_diabetic_patients_with_acute_myocardial_infarction_Cardiovascular_co_morbidities_contribute_most_to_the_high_risk">High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk</a></div><div class="wp-workCard_item"><span>International Journal of Cardiology</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="67b4308fdb4d2371b4914499b3b5f13e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50652433,"asset_id":30192871,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50652433/download_file?st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192871"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192871"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192871; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192871]").text(description); $(".js-view-count[data-work-id=30192871]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192871; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192871']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192871, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "67b4308fdb4d2371b4914499b3b5f13e" } } $('.js-work-strip[data-work-id=30192871]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192871,"title":"High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk","translated_title":"","metadata":{"grobid_abstract":"Background: High mortality rates have been reported in diabetic patients after acute myocardial infarction (AMI). The excess mortality has been attributed to the diabetic state itself. We aimed to investigate how other risk factors along with diabetes per se may predict mortality in an unselected AMI population. Methods: A representative sample of an unselected AMI population was collected over a three-month period. Data on patients' histories, comorbidity, presenting features and treatment were collected from medical records. The data sets included outcome variables at discharge, after 6 months and after 2.5 years. Patients with confirmed diabetes on admission to hospital were registered as diabetic patients. Results: Of the 901 patients admitted to hospital with AMI, 121 (14%) were diabetic patients. Compared with the nondiabetic patients significantly fewer of the diabetic patients were alive at discharge (78% vs 86%), after 6 months (64% vs 78%) and after 2.5 years (42% vs 65%). In multiple logistic regression analyses adjusted for age, sex and smoking status, the most important predictor of death at 2.5 years was heart failure, followed by previous MI, diabetes, and angina pectoris. The population attributable risk (PAR) of death after 2.5 years was 7% for diabetes, 17% for previous MI, 13% for heart failure and 12% for angina pectoris. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192868"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192868/The_problem_of_underdosing_of_angiotensin_converting_enzyme_inhibitors_is_markedly_overrated_results_from_a_study_of_patients_discharged_from_hospital_after_an_acute_myocardial_infarction"><img alt="Research paper thumbnail of The problem of underdosing of angiotensin-converting enzyme inhibitors is markedly overrated: results from a study of patients discharged from hospital after an acute myocardial infarction" class="work-thumbnail" src="https://attachments.academia-assets.com/50652432/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192868/The_problem_of_underdosing_of_angiotensin_converting_enzyme_inhibitors_is_markedly_overrated_results_from_a_study_of_patients_discharged_from_hospital_after_an_acute_myocardial_infarction">The problem of underdosing of angiotensin-converting enzyme inhibitors is markedly overrated: results from a study of patients discharged from hospital after an acute myocardial infarction</a></div><div class="wp-workCard_item"><span>European Journal of Clinical Pharmacology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="016427c41cdf1e5098e05f9882db83db" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50652432,"asset_id":30192868,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50652432/download_file?st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192868"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192868"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192868; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192868]").text(description); $(".js-view-count[data-work-id=30192868]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192868; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192868']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192868, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "016427c41cdf1e5098e05f9882db83db" } } $('.js-work-strip[data-work-id=30192868]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192868,"title":"The problem of underdosing of angiotensin-converting enzyme inhibitors is markedly overrated: results from a study of patients discharged from hospital after an acute myocardial infarction","translated_title":"","metadata":{"ai_title_tag":"ACE Inhibitor Dosing After Myocardial Infarction: A Study","grobid_abstract":"Objective: The use of angiotensin-converting enzyme (ACE) inhibitors has increased markedly during the last decade. It has been claimed that doses of ACE inhibitors prescribed in clinical practice are considerably lower than the target doses used in randomized clinical trials. The aim of the study was to investigate dosing of ACE inhibitors in patients discharged from the hospital after an acute myocardial infarction (AMI) and, furthermore, to compare these doses with the doses actually reached in clinical trials. Methods: From 16 hospitals, we drew a sample of patients who were discharged alive with the diagnosis of AMI during a 3-month period in 1999/2000. From medical records, physicians in each hospital obtained the observed rate of cardiovascular drugs at discharge, including type and doses of ACE inhibitors. The clinicians' main indication for ACE inhibitor use was also reported. Outcome variables, including deaths and drug utilization with dosing after 6 months, were collected. Results: Of a total of 767 patients discharged alive, 274 patients received an ACE inhibitor. The daily mean doses of the four ACE inhibitors used in the study were as follows: captopril 69.8±36.9 mg (n=44), enalapril 13.6±8.1 mg (n=75), lisinopril 11.0±7.2 mg (n=114), and ramipril 8.4±4.5 mg (n=38). The doses were unchanged after 6 months except for captopril, which showed a rise in mean daily dose to 84.4±36.7 mg. Ramipril compared most favorably with clinical trial medications, while captopril deviated most. The indication of hypertension was associated with slightly higher doses than the indication of secondary prevention. Conclusion: AMI patients were discharged from the hospital with ACE inhibitor doses fairly close to the ones achieved in clinical trials showing survival benefits for ACE inhibitors. A distinction should be made between target doses and doses actually obtained in clinical trials.","publication_date":{"day":null,"month":null,"year":2004,"errors":{}},"publication_name":"European Journal of Clinical 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Trial","url":"https://www.academia.edu/Documents/in/Clinical_Trial"},{"id":52836,"name":"Clinical Practice","url":"https://www.academia.edu/Documents/in/Clinical_Practice"},{"id":71284,"name":"Enalapril","url":"https://www.academia.edu/Documents/in/Enalapril"},{"id":96213,"name":"Hospitalization","url":"https://www.academia.edu/Documents/in/Hospitalization"},{"id":172151,"name":"Acute Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Acute_Myocardial_Infarction"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":719604,"name":"Angiotensin Converting Enzyme","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme"},{"id":874382,"name":"Medical 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"profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192867"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192867/Health_related_quality_of_life_after_myocardial_infarction_is_associated_with_level_of_left_ventricular_ejection_fraction"><img alt="Research paper thumbnail of Health-related quality of life after myocardial infarction is associated with level of left ventricular ejection fraction" class="work-thumbnail" src="https://attachments.academia-assets.com/50652431/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192867/Health_related_quality_of_life_after_myocardial_infarction_is_associated_with_level_of_left_ventricular_ejection_fraction">Health-related quality of life after myocardial infarction is associated with level of left ventricular ejection fraction</a></div><div class="wp-workCard_item"><span>BMC Cardiovascular Disorders</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bf0ee1a49b7c8432fe0fd67c440f40a9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50652431,"asset_id":30192867,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50652431/download_file?st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" 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class="js-work-strip profile--work_container" data-work-id="30192866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192866/Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality"><img alt="Research paper thumbnail of Antihypertensive Therapy at the Onset of an Acute Myocardial Infarction Predicts In-hospital Mortality" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192866/Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality">Antihypertensive Therapy at the Onset of an Acute Myocardial Infarction Predicts In-hospital Mortality</a></div><div class="wp-workCard_item"><span>Blood Pressure</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several studies, which have compared the efficacy of conventional antihypertensive drugs (thiazid...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several studies, which have compared the efficacy of conventional antihypertensive drugs (thiazide diuretics and beta-blockers) with the newer agents [calcium blockers and angiotensin-converting enzyme (ACE) inhibitors], have shown that they are almost equally efficacious with regard to effects on blood pressure, and in preventing cardiovascular morbidity and mortality. The potential value of these drugs when hypertensive patients suffer an acute myocardial infarction (AMI) has, however, not been fully elucidated. The objective of the present observational study was to investigate whether prior use of different antihypertensive drugs could modify or influence in-hospital death in hypertensives suffering an AMI. A total of 299 hypertensive patients with the diagnosis of AMI were included. The demographic data were obtained from medical records. Variables were entered into a logistic regression model. The main predictors of death were age (adjusted odds ratio (ORa) 1.07, p = 0.002 (per each year), and the use of diuretics (ORa 2.54, p = 0.018) and calcium blockers (ORa 2.54, p = 0.010). On the other hand, the use of ACE inhibitors was associated with a marked reduction of in-hospital death (ORa 0.44, p = 0.045). The present study indicates that while the use of ACE inhibitors was associated with a reduced risk of in-hospital death in hypertensive patients suffering an AMI, the use of diuretics and calcium blockers was associated with increased risks.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192866"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192866"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192866; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192866]").text(description); $(".js-view-count[data-work-id=30192866]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192866; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192866']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192866, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192866]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192866,"title":"Antihypertensive Therapy at the Onset of an Acute Myocardial Infarction Predicts In-hospital Mortality","translated_title":"","metadata":{"abstract":"Several studies, which have compared the efficacy of conventional antihypertensive drugs (thiazide diuretics and beta-blockers) with the newer agents [calcium blockers and angiotensin-converting enzyme (ACE) inhibitors], have shown that they are almost equally efficacious with regard to effects on blood pressure, and in preventing cardiovascular morbidity and mortality. The potential value of these drugs when hypertensive patients suffer an acute myocardial infarction (AMI) has, however, not been fully elucidated. The objective of the present observational study was to investigate whether prior use of different antihypertensive drugs could modify or influence in-hospital death in hypertensives suffering an AMI. A total of 299 hypertensive patients with the diagnosis of AMI were included. The demographic data were obtained from medical records. Variables were entered into a logistic regression model. The main predictors of death were age (adjusted odds ratio (ORa) 1.07, p = 0.002 (per each year), and the use of diuretics (ORa 2.54, p = 0.018) and calcium blockers (ORa 2.54, p = 0.010). On the other hand, the use of ACE inhibitors was associated with a marked reduction of in-hospital death (ORa 0.44, p = 0.045). The present study indicates that while the use of ACE inhibitors was associated with a reduced risk of in-hospital death in hypertensive patients suffering an AMI, the use of diuretics and calcium blockers was associated with increased risks.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Blood Pressure"},"translated_abstract":"Several studies, which have compared the efficacy of conventional antihypertensive drugs (thiazide diuretics and beta-blockers) with the newer agents [calcium blockers and angiotensin-converting enzyme (ACE) inhibitors], have shown that they are almost equally efficacious with regard to effects on blood pressure, and in preventing cardiovascular morbidity and mortality. The potential value of these drugs when hypertensive patients suffer an acute myocardial infarction (AMI) has, however, not been fully elucidated. The objective of the present observational study was to investigate whether prior use of different antihypertensive drugs could modify or influence in-hospital death in hypertensives suffering an AMI. A total of 299 hypertensive patients with the diagnosis of AMI were included. The demographic data were obtained from medical records. Variables were entered into a logistic regression model. The main predictors of death were age (adjusted odds ratio (ORa) 1.07, p = 0.002 (per each year), and the use of diuretics (ORa 2.54, p = 0.018) and calcium blockers (ORa 2.54, p = 0.010). On the other hand, the use of ACE inhibitors was associated with a marked reduction of in-hospital death (ORa 0.44, p = 0.045). The present study indicates that while the use of ACE inhibitors was associated with a reduced risk of in-hospital death in hypertensive patients suffering an AMI, the use of diuretics and calcium blockers was associated with increased risks.","internal_url":"https://www.academia.edu/30192866/Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality","translated_internal_url":"","created_at":"2016-12-01T00:31:01.119-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":89995,"name":"Diuretics","url":"https://www.academia.edu/Documents/in/Diuretics"},{"id":194640,"name":"Patient Admission","url":"https://www.academia.edu/Documents/in/Patient_Admission"},{"id":195985,"name":"Aspirin","url":"https://www.academia.edu/Documents/in/Aspirin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":400209,"name":"Warfarin","url":"https://www.academia.edu/Documents/in/Warfarin"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":901284,"name":"Hospital Mortality","url":"https://www.academia.edu/Documents/in/Hospital_Mortality"},{"id":1200766,"name":"Drug Utilization","url":"https://www.academia.edu/Documents/in/Drug_Utilization"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1954221,"name":"Calcium Channel Blockers","url":"https://www.academia.edu/Documents/in/Calcium_Channel_Blockers"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30032335"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30032335/Pharmacology_Portal_An_Open_Database_for_Clinical_Pharmacologic_Laboratory_Services"><img alt="Research paper thumbnail of Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30032335/Pharmacology_Portal_An_Open_Database_for_Clinical_Pharmacologic_Laboratory_Services">Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://idv.academia.edu/AndreasWestin">Andreas Westin</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://uio.academia.edu/ThorHilberg">Thor Hilberg</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElenaKvan">Elena Kvan</a></span></div><div class="wp-workCard_item"><span>Clinical Therapeutics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">More than 50 Norwegian public and private laboratories provide one or more analyses for therapeut...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">More than 50 Norwegian public and private laboratories provide one or more analyses for therapeutic drug monitoring or testing for drugs of abuse. Practices differ among laboratories, and analytical repertoires can change rapidly as new substances become available for analysis. The Pharmacology Portal was developed to provide an overview of these activities and to standardize the practices and terminology among laboratories. The Pharmacology Portal is a modern dynamic web database comprising all available analyses within therapeutic drug monitoring and testing for drugs of abuse in Norway. Content can be retrieved by using the search engine or by scrolling through substance lists. The core content is a substance registry updated by a national editorial board of experts within the field of clinical pharmacology. This ensures quality and consistency regarding substance terminologies and classification. All laboratories publish their own repertoires in a user-friendly workflow, adding laboratory-specific details to the core information in the substance registry. The user management system ensures that laboratories are restricted from editing content in the database core or in repertoires within other laboratory subpages. The portal is for nonprofit use, and has been fully funded by the Norwegian Medical Association, the Norwegian Society of Clinical Pharmacology, and the 8 largest pharmacologic institutions in Norway. The database server runs an open-source content management system that ensures flexibility with respect to further development projects, including the potential expansion of the Pharmacology Portal to other countries.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30032335"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30032335"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30032335; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30032335]").text(description); $(".js-view-count[data-work-id=30032335]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30032335; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30032335']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30032335, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30032335]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30032335,"title":"Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services","translated_title":"","metadata":{"abstract":"More than 50 Norwegian public and private laboratories provide one or more analyses for therapeutic drug monitoring or testing for drugs of abuse. 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container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9c853fcab328f52d530e5bf70876deb0" } } $('.js-work-strip[data-work-id=30192880]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192880,"title":"High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk","translated_title":"","metadata":{"grobid_abstract":"Background: High mortality rates have been reported in diabetic patients after acute myocardial infarction (AMI). The excess mortality has been attributed to the diabetic state itself. We aimed to investigate how other risk factors along with diabetes per se may predict mortality in an unselected AMI population. Methods: A representative sample of an unselected AMI population was collected over a three-month period. Data on patients' histories, comorbidity, presenting features and treatment were collected from medical records. The data sets included outcome variables at discharge, after 6 months and after 2.5 years. Patients with confirmed diabetes on admission to hospital were registered as diabetic patients. Results: Of the 901 patients admitted to hospital with AMI, 121 (14%) were diabetic patients. Compared with the nondiabetic patients significantly fewer of the diabetic patients were alive at discharge (78% vs 86%), after 6 months (64% vs 78%) and after 2.5 years (42% vs 65%). In multiple logistic regression analyses adjusted for age, sex and smoking status, the most important predictor of death at 2.5 years was heart failure, followed by previous MI, diabetes, and angina pectoris. The population attributable risk (PAR) of death after 2.5 years was 7% for diabetes, 17% for previous MI, 13% for heart failure and 12% for angina pectoris. 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192879/Kj_nnsforskjeller_og_kardiovaskul_re_legemidler">Kj�nnsforskjeller og�kardiovaskul�re legemidler</a></div><div class="wp-workCard_item"><span>Tidsskr Norske Laegeforen</span><span>, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192879"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192879"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192879; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192879]").text(description); $(".js-view-count[data-work-id=30192879]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192879; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192879']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192879, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192879]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192879,"title":"Kj�nnsforskjeller og�kardiovaskul�re 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data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192878/_Sex_differences_and_cardiovascular_drugs_">[Sex differences and cardiovascular drugs]</a></div><div class="wp-workCard_item"><span>Tidsskrift for den Norske laegeforening</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the western world, cardiovascular disease is the leading cause of death for both sexes. These ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the western world, cardiovascular disease is the leading cause of death for both sexes. These diseases show substantial differences between the sexes with respect to epidemiology, biology and clinical aspects. In recent years, more attention has been directed towards sex differences in pharmacological effects. Although both sexes are included in most pharmacological trials, the proportion of women is often too low to enable sex-specific analyses.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192878; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192878]").text(description); $(".js-view-count[data-work-id=30192878]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192878; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192878']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192878, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192878]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192878,"title":"[Sex differences and cardiovascular drugs]","translated_title":"","metadata":{"abstract":"In the western world, cardiovascular disease is the leading cause of death for both sexes. These diseases show substantial differences between the sexes with respect to epidemiology, biology and clinical aspects. In recent years, more attention has been directed towards sex differences in pharmacological effects. Although both sexes are included in most pharmacological trials, the proportion of women is often too low to enable sex-specific analyses.","publication_name":"Tidsskrift for den Norske laegeforening"},"translated_abstract":"In the western world, cardiovascular disease is the leading cause of death for both sexes. These diseases show substantial differences between the sexes with respect to epidemiology, biology and clinical aspects. In recent years, more attention has been directed towards sex differences in pharmacological effects. 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These ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the western world, cardiovascular disease is the leading cause of death for both sexes. These diseases show substantial differences between the sexes with respect to epidemiology, biology and clinical aspects. In recent years, more attention has been directed towards sex differences in pharmacological effects. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192875"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192875/Use_of_cardiovascular_drugs_after_acute_myocardial_infarction_a_marked_shift_towards_evidence_based_drug_therapy"><img alt="Research paper thumbnail of Use of cardiovascular drugs after acute myocardial infarction: a marked shift towards evidence-based drug therapy" class="work-thumbnail" src="https://attachments.academia-assets.com/50652436/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192875/Use_of_cardiovascular_drugs_after_acute_myocardial_infarction_a_marked_shift_towards_evidence_based_drug_therapy">Use of cardiovascular drugs after acute myocardial infarction: a marked shift towards evidence-based drug therapy</a></div><div class="wp-workCard_item"><span>Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy</span><span>, 2002</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To investigate the prescription pattern for cardiovascular drugs among patients discharged after ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To investigate the prescription pattern for cardiovascular drugs among patients discharged after an acute myocardial infarction (AMI) in hospitals that had participated in a corresponding study seven years earlier, and examine what the indications were for use of the different drugs. From 16 hospitals we drew a sample of patients who were discharged with a diagnosis of AMI during a three months period in 1999/2000. Physicians in each hospital obtained from the medical records the observed rate of use of cardiovascular drugs at discharge. The drug use was compared with findings from a corresponding sample drawn in 1993. The main indication for use of the different cardiovascular drugs was recorded for the 1999/2000 sample. 399 patients discharged alive were included in the first study and 767 in the second. The use of beta-blockers, ACE inhibitors and statins rose substantially during the period. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192874"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192874/RAS_hemmere_og_infarktst%C3%B8rrelse"><img alt="Research paper thumbnail of RAS-hemmere og infarktstørrelse" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192874/RAS_hemmere_og_infarktst%C3%B8rrelse">RAS-hemmere og infarktstørrelse</a></div><div class="wp-workCard_item"><span>Tidsskrift for Den norske legeforening</span><span>, 2011</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192874"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192874"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192874; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192873"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192873/Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function"><img alt="Research paper thumbnail of Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192873/Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function">Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function</a></div><div class="wp-workCard_item"><span>Scandinavian Cardiovascular Journal</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">To investigate to what extent and by what methods clinicians assess left ventricular (LV) functio...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">To investigate to what extent and by what methods clinicians assess left ventricular (LV) function after an acute myocardial infarction (AMI) and how the results of the assessments relate to the use of angiotensin-converting enzyme (ACE) inhibitors; furthermore, to explore which main indications caused the clinicians to initiate ACE inhibitor therapy. From 16 hospitals we drew a sample of patients who were discharged with the diagnosis of AMI during a 3-month period in 1999/2000. Physicians in each hospital obtained the observed rate of use of cardiovascular drugs at discharge and also information on ejection fraction (EF) measurements. The results of the EF recordings were classified into three categories: &amp;amp;amp;amp;amp;gt;0.50, 0.40-0.50 and &amp;amp;amp;amp;amp;lt;0.40. The clinicians&amp;amp;amp;amp;amp;#39; main indications for drug use were reported. Among 767 patients discharged alive, EF was measured in 409 (53%), by echocardiography in 53% and by radionuclide ventriculography in 47%. Of the 409 patients 227 (55%) had EF &amp;amp;amp;amp;amp;gt;0.50, 95 (24%) EF 0.40-0.50 and 87 (21%) EF &amp;amp;amp;amp;amp;lt;0.40. Adjusted odds ratio for ACE inhibitor therapy being initiated during the AMI was 13.5 for those with EF &amp;amp;amp;amp;amp;lt;0.40 compared with those with EF &amp;amp;amp;amp;amp;gt;0.50. The main indication for starting ACE inhibitor therapy was heart failure (50%) followed by secondary prevention (42%). Measuring EF appears to be an important tool in the evaluation of AMI patients prior to discharge from hospital. Initiation of ACE inhibitor therapy related strongly to the results of the assessments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192873"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192873"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192873; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192873]").text(description); $(".js-view-count[data-work-id=30192873]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192873; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192873']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192873, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192873]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192873,"title":"Angiotensin-converting enzyme (ACE) inhibitor therapy after myocardial infarction in relation to left ventricular function","translated_title":"","metadata":{"abstract":"To investigate to what extent and by what methods clinicians assess left ventricular (LV) function after an acute myocardial infarction (AMI) and how the results of the assessments relate to the use of angiotensin-converting enzyme (ACE) inhibitors; furthermore, to explore which main indications caused the clinicians to initiate ACE inhibitor therapy. From 16 hospitals we drew a sample of patients who were discharged with the diagnosis of AMI during a 3-month period in 1999/2000. Physicians in each hospital obtained the observed rate of use of cardiovascular drugs at discharge and also information on ejection fraction (EF) measurements. The results of the EF recordings were classified into three categories: \u0026amp;amp;amp;amp;amp;gt;0.50, 0.40-0.50 and \u0026amp;amp;amp;amp;amp;lt;0.40. The clinicians\u0026amp;amp;amp;amp;amp;#39; main indications for drug use were reported. Among 767 patients discharged alive, EF was measured in 409 (53%), by echocardiography in 53% and by radionuclide ventriculography in 47%. Of the 409 patients 227 (55%) had EF \u0026amp;amp;amp;amp;amp;gt;0.50, 95 (24%) EF 0.40-0.50 and 87 (21%) EF \u0026amp;amp;amp;amp;amp;lt;0.40. Adjusted odds ratio for ACE inhibitor therapy being initiated during the AMI was 13.5 for those with EF \u0026amp;amp;amp;amp;amp;lt;0.40 compared with those with EF \u0026amp;amp;amp;amp;amp;gt;0.50. The main indication for starting ACE inhibitor therapy was heart failure (50%) followed by secondary prevention (42%). Measuring EF appears to be an important tool in the evaluation of AMI patients prior to discharge from hospital. Initiation of ACE inhibitor therapy related strongly to the results of the assessments.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Scandinavian Cardiovascular Journal"},"translated_abstract":"To investigate to what extent and by what methods clinicians assess left ventricular (LV) function after an acute myocardial infarction (AMI) and how the results of the assessments relate to the use of angiotensin-converting enzyme (ACE) inhibitors; furthermore, to explore which main indications caused the clinicians to initiate ACE inhibitor therapy. From 16 hospitals we drew a sample of patients who were discharged with the diagnosis of AMI during a 3-month period in 1999/2000. Physicians in each hospital obtained the observed rate of use of cardiovascular drugs at discharge and also information on ejection fraction (EF) measurements. The results of the EF recordings were classified into three categories: \u0026amp;amp;amp;amp;amp;gt;0.50, 0.40-0.50 and \u0026amp;amp;amp;amp;amp;lt;0.40. The clinicians\u0026amp;amp;amp;amp;amp;#39; main indications for drug use were reported. Among 767 patients discharged alive, EF was measured in 409 (53%), by echocardiography in 53% and by radionuclide ventriculography in 47%. Of the 409 patients 227 (55%) had EF \u0026amp;amp;amp;amp;amp;gt;0.50, 95 (24%) EF 0.40-0.50 and 87 (21%) EF \u0026amp;amp;amp;amp;amp;lt;0.40. Adjusted odds ratio for ACE inhibitor therapy being initiated during the AMI was 13.5 for those with EF \u0026amp;amp;amp;amp;amp;lt;0.40 compared with those with EF \u0026amp;amp;amp;amp;amp;gt;0.50. The main indication for starting ACE inhibitor therapy was heart failure (50%) followed by secondary prevention (42%). Measuring EF appears to be an important tool in the evaluation of AMI patients prior to discharge from hospital. Initiation of ACE inhibitor therapy related strongly to the results of the assessments.","internal_url":"https://www.academia.edu/30192873/Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function","translated_internal_url":"","created_at":"2016-12-01T00:31:01.933-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Angiotensin_converting_enzyme_ACE_inhibitor_therapy_after_myocardial_infarction_in_relation_to_left_ventricular_function","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":8942,"name":"Treatment","url":"https://www.academia.edu/Documents/in/Treatment"},{"id":12426,"name":"Treatment Outcome","url":"https://www.academia.edu/Documents/in/Treatment_Outcome"},{"id":33069,"name":"Probability","url":"https://www.academia.edu/Documents/in/Probability"},{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway"},{"id":74347,"name":"Hemodynamics","url":"https://www.academia.edu/Documents/in/Hemodynamics"},{"id":100657,"name":"Therapy","url":"https://www.academia.edu/Documents/in/Therapy"},{"id":129744,"name":"Confidence intervals","url":"https://www.academia.edu/Documents/in/Confidence_intervals"},{"id":198747,"name":"Left Ventricular Dysfunction","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Dysfunction"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate"},{"id":489727,"name":"Prognosis","url":"https://www.academia.edu/Documents/in/Prognosis"},{"id":719604,"name":"Angiotensin Converting Enzyme","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme"},{"id":918981,"name":"Left Ventricular Function","url":"https://www.academia.edu/Documents/in/Left_Ventricular_Function"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1294607,"name":"Logistic Models","url":"https://www.academia.edu/Documents/in/Logistic_Models"},{"id":1425542,"name":"ACE Inhibitor","url":"https://www.academia.edu/Documents/in/ACE_Inhibitor"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"},{"id":2463800,"name":"Severity of Illness Index","url":"https://www.academia.edu/Documents/in/Severity_of_Illness_Index"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192872"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192872/Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention"><img alt="Research paper thumbnail of Treatment with statins after acute myocardial infarction in patients ≥80 years: underuse despite general acceptance of drug therapy for secondary prevention" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192872/Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention">Treatment with statins after acute myocardial infarction in patients ≥80 years: underuse despite general acceptance of drug therapy for secondary prevention</a></div><div class="wp-workCard_item"><span>Pharmacoepidemiology and Drug Safety</span><span>, 2006</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">It has not been decided to what extent the results from statin trials should be transferred to cl...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">It has not been decided to what extent the results from statin trials should be transferred to clinical practice in the very old. The aim of the study was to assess the use of cardiovascular drugs after an acute myocardial infarction (MI), with particular focus on statins, in very old patients as compared to younger patients. A sample of 901 acute MI patients was drawn from 16 hospitals in 1999/2000; the patients were followed up for 2.5 years. Information on demographic variables and drug therapy was obtained from hospital records, and in the follow-up period by direct patient contact or questionnaire. The main indications for prescribing the various cardiovascular drugs were recorded. At discharge, drug use in patients &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years, respectively, was as follows: ACE-inhibitors 48 versus 32%, nitrates 55 versus 32%, diuretics 64 versus 26%, aspirin 72 versus 86%, and beta-blockers 67 versus 85%. A striking difference was found for statins: 9% in the very old and 72% in younger patients. The pattern of drug use generally remained unchanged after 2.5 years. Survival rates for patients &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years: at discharge 72 versus 90%, after 2.5 years 34 versus 73%. Drug therapy was widely accepted for the indication secondary prevention after MI in patients above 80 years of age. The various cardiovascular drugs were prescribed to about the same extent for very old and younger patients. The exception was lipid lowering drugs which, despite the physicians&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; recognition of the indication secondary prevention in the very old patients, were prescribed to a limited extent.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192872"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192872"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192872; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192872]").text(description); $(".js-view-count[data-work-id=30192872]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192872; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192872']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192872, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30192872]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192872,"title":"Treatment with statins after acute myocardial infarction in patients ≥80 years: underuse despite general acceptance of drug therapy for secondary prevention","translated_title":"","metadata":{"abstract":"It has not been decided to what extent the results from statin trials should be transferred to clinical practice in the very old. The aim of the study was to assess the use of cardiovascular drugs after an acute myocardial infarction (MI), with particular focus on statins, in very old patients as compared to younger patients. A sample of 901 acute MI patients was drawn from 16 hospitals in 1999/2000; the patients were followed up for 2.5 years. Information on demographic variables and drug therapy was obtained from hospital records, and in the follow-up period by direct patient contact or questionnaire. The main indications for prescribing the various cardiovascular drugs were recorded. At discharge, drug use in patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years, respectively, was as follows: ACE-inhibitors 48 versus 32%, nitrates 55 versus 32%, diuretics 64 versus 26%, aspirin 72 versus 86%, and beta-blockers 67 versus 85%. A striking difference was found for statins: 9% in the very old and 72% in younger patients. The pattern of drug use generally remained unchanged after 2.5 years. Survival rates for patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years: at discharge 72 versus 90%, after 2.5 years 34 versus 73%. Drug therapy was widely accepted for the indication secondary prevention after MI in patients above 80 years of age. The various cardiovascular drugs were prescribed to about the same extent for very old and younger patients. The exception was lipid lowering drugs which, despite the physicians\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; recognition of the indication secondary prevention in the very old patients, were prescribed to a limited extent.","publication_date":{"day":null,"month":null,"year":2006,"errors":{}},"publication_name":"Pharmacoepidemiology and Drug Safety"},"translated_abstract":"It has not been decided to what extent the results from statin trials should be transferred to clinical practice in the very old. The aim of the study was to assess the use of cardiovascular drugs after an acute myocardial infarction (MI), with particular focus on statins, in very old patients as compared to younger patients. A sample of 901 acute MI patients was drawn from 16 hospitals in 1999/2000; the patients were followed up for 2.5 years. Information on demographic variables and drug therapy was obtained from hospital records, and in the follow-up period by direct patient contact or questionnaire. The main indications for prescribing the various cardiovascular drugs were recorded. At discharge, drug use in patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years, respectively, was as follows: ACE-inhibitors 48 versus 32%, nitrates 55 versus 32%, diuretics 64 versus 26%, aspirin 72 versus 86%, and beta-blockers 67 versus 85%. A striking difference was found for statins: 9% in the very old and 72% in younger patients. The pattern of drug use generally remained unchanged after 2.5 years. Survival rates for patients \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;or=80 and \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;80 years: at discharge 72 versus 90%, after 2.5 years 34 versus 73%. Drug therapy was widely accepted for the indication secondary prevention after MI in patients above 80 years of age. The various cardiovascular drugs were prescribed to about the same extent for very old and younger patients. The exception was lipid lowering drugs which, despite the physicians\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; recognition of the indication secondary prevention in the very old patients, were prescribed to a limited extent.","internal_url":"https://www.academia.edu/30192872/Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention","translated_internal_url":"","created_at":"2016-12-01T00:31:01.836-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Treatment_with_statins_after_acute_myocardial_infarction_in_patients_80_years_underuse_despite_general_acceptance_of_drug_therapy_for_secondary_prevention","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":10610,"name":"Survival Analysis","url":"https://www.academia.edu/Documents/in/Survival_Analysis"},{"id":51645,"name":"Norway","url":"https://www.academia.edu/Documents/in/Norway"},{"id":66080,"name":"Age","url":"https://www.academia.edu/Documents/in/Age"},{"id":172151,"name":"Acute Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Acute_Myocardial_Infarction"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":327850,"name":"Questionnaires","url":"https://www.academia.edu/Documents/in/Questionnaires"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":410370,"name":"Public health systems and services research","url":"https://www.academia.edu/Documents/in/Public_health_systems_and_services_research-1"},{"id":555323,"name":"Drug Therapy","url":"https://www.academia.edu/Documents/in/Drug_Therapy"},{"id":874382,"name":"Medical Records","url":"https://www.academia.edu/Documents/in/Medical_Records"},{"id":1200766,"name":"Drug Utilization","url":"https://www.academia.edu/Documents/in/Drug_Utilization"},{"id":1246554,"name":"SECONDARY PREVENTION","url":"https://www.academia.edu/Documents/in/SECONDARY_PREVENTION"},{"id":1698107,"name":"Pharmacoepidemiology and drug safety","url":"https://www.academia.edu/Documents/in/Pharmacoepidemiology_and_drug_safety"},{"id":2060696,"name":"Health services for the aged","url":"https://www.academia.edu/Documents/in/Health_services_for_the_aged"},{"id":2491318,"name":"Guideline Adherence","url":"https://www.academia.edu/Documents/in/Guideline_Adherence"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30192871"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192871/High_mortality_in_diabetic_patients_with_acute_myocardial_infarction_Cardiovascular_co_morbidities_contribute_most_to_the_high_risk"><img alt="Research paper thumbnail of High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk" class="work-thumbnail" src="https://attachments.academia-assets.com/50652433/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192871/High_mortality_in_diabetic_patients_with_acute_myocardial_infarction_Cardiovascular_co_morbidities_contribute_most_to_the_high_risk">High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk</a></div><div class="wp-workCard_item"><span>International Journal of Cardiology</span><span>, 2007</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="67b4308fdb4d2371b4914499b3b5f13e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50652433,"asset_id":30192871,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50652433/download_file?st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30192871"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30192871"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30192871; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30192871]").text(description); $(".js-view-count[data-work-id=30192871]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30192871; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30192871']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30192871, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "67b4308fdb4d2371b4914499b3b5f13e" } } $('.js-work-strip[data-work-id=30192871]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192871,"title":"High mortality in diabetic patients with acute myocardial infarction: Cardiovascular co-morbidities contribute most to the high risk","translated_title":"","metadata":{"grobid_abstract":"Background: High mortality rates have been reported in diabetic patients after acute myocardial infarction (AMI). The excess mortality has been attributed to the diabetic state itself. We aimed to investigate how other risk factors along with diabetes per se may predict mortality in an unselected AMI population. Methods: A representative sample of an unselected AMI population was collected over a three-month period. Data on patients' histories, comorbidity, presenting features and treatment were collected from medical records. The data sets included outcome variables at discharge, after 6 months and after 2.5 years. Patients with confirmed diabetes on admission to hospital were registered as diabetic patients. Results: Of the 901 patients admitted to hospital with AMI, 121 (14%) were diabetic patients. Compared with the nondiabetic patients significantly fewer of the diabetic patients were alive at discharge (78% vs 86%), after 6 months (64% vs 78%) and after 2.5 years (42% vs 65%). In multiple logistic regression analyses adjusted for age, sex and smoking status, the most important predictor of death at 2.5 years was heart failure, followed by previous MI, diabetes, and angina pectoris. The population attributable risk (PAR) of death after 2.5 years was 7% for diabetes, 17% for previous MI, 13% for heart failure and 12% for angina pectoris. Conclusion: Among patients with diabetes suffering an AMI the already established cardiovascular co-morbidities, which previously partly or fully might have been caused by diabetes, contributed more than diabetes per se to high mortality in-hospital and in the follow-up period.","publication_date":{"day":null,"month":null,"year":2007,"errors":{}},"publication_name":"International Journal of 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wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192868/The_problem_of_underdosing_of_angiotensin_converting_enzyme_inhibitors_is_markedly_overrated_results_from_a_study_of_patients_discharged_from_hospital_after_an_acute_myocardial_infarction">The problem of underdosing of angiotensin-converting enzyme inhibitors is markedly overrated: results from a study of patients discharged from hospital after an acute myocardial infarction</a></div><div class="wp-workCard_item"><span>European Journal of Clinical Pharmacology</span><span>, 2004</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="016427c41cdf1e5098e05f9882db83db" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" 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id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "016427c41cdf1e5098e05f9882db83db" } } $('.js-work-strip[data-work-id=30192868]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30192868,"title":"The problem of underdosing of angiotensin-converting enzyme inhibitors is markedly overrated: results from a study of patients discharged from hospital after an acute myocardial infarction","translated_title":"","metadata":{"ai_title_tag":"ACE Inhibitor Dosing After Myocardial Infarction: A Study","grobid_abstract":"Objective: The use of angiotensin-converting enzyme (ACE) inhibitors has increased markedly during the last decade. It has been claimed that doses of ACE inhibitors prescribed in clinical practice are considerably lower than the target doses used in randomized clinical trials. The aim of the study was to investigate dosing of ACE inhibitors in patients discharged from the hospital after an acute myocardial infarction (AMI) and, furthermore, to compare these doses with the doses actually reached in clinical trials. Methods: From 16 hospitals, we drew a sample of patients who were discharged alive with the diagnosis of AMI during a 3-month period in 1999/2000. From medical records, physicians in each hospital obtained the observed rate of cardiovascular drugs at discharge, including type and doses of ACE inhibitors. The clinicians' main indication for ACE inhibitor use was also reported. Outcome variables, including deaths and drug utilization with dosing after 6 months, were collected. Results: Of a total of 767 patients discharged alive, 274 patients received an ACE inhibitor. The daily mean doses of the four ACE inhibitors used in the study were as follows: captopril 69.8±36.9 mg (n=44), enalapril 13.6±8.1 mg (n=75), lisinopril 11.0±7.2 mg (n=114), and ramipril 8.4±4.5 mg (n=38). The doses were unchanged after 6 months except for captopril, which showed a rise in mean daily dose to 84.4±36.7 mg. Ramipril compared most favorably with clinical trial medications, while captopril deviated most. The indication of hypertension was associated with slightly higher doses than the indication of secondary prevention. Conclusion: AMI patients were discharged from the hospital with ACE inhibitor doses fairly close to the ones achieved in clinical trials showing survival benefits for ACE inhibitors. 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href="https://www.academia.edu/30192867/Health_related_quality_of_life_after_myocardial_infarction_is_associated_with_level_of_left_ventricular_ejection_fraction">Health-related quality of life after myocardial infarction is associated with level of left ventricular ejection fraction</a></div><div class="wp-workCard_item"><span>BMC Cardiovascular Disorders</span><span>, 2008</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bf0ee1a49b7c8432fe0fd67c440f40a9" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":50652431,"asset_id":30192867,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/50652431/download_file?st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&st=MTczMjc1MDQ5MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action 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class="js-work-strip profile--work_container" data-work-id="30192866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30192866/Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality"><img alt="Research paper thumbnail of Antihypertensive Therapy at the Onset of an Acute Myocardial Infarction Predicts In-hospital Mortality" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30192866/Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality">Antihypertensive Therapy at the Onset of an Acute Myocardial Infarction Predicts In-hospital Mortality</a></div><div class="wp-workCard_item"><span>Blood Pressure</span><span>, 2003</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Several studies, which have compared the efficacy of conventional antihypertensive drugs (thiazid...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Several studies, which have compared the efficacy of conventional antihypertensive drugs (thiazide diuretics and beta-blockers) with the newer agents [calcium blockers and angiotensin-converting enzyme (ACE) inhibitors], have shown that they are almost equally efficacious with regard to effects on blood pressure, and in preventing cardiovascular morbidity and mortality. The potential value of these drugs when hypertensive patients suffer an acute myocardial infarction (AMI) has, however, not been fully elucidated. The objective of the present observational study was to investigate whether prior use of different antihypertensive drugs could modify or influence in-hospital death in hypertensives suffering an AMI. A total of 299 hypertensive patients with the diagnosis of AMI were included. The demographic data were obtained from medical records. Variables were entered into a logistic regression model. The main predictors of death were age (adjusted odds ratio (ORa) 1.07, p = 0.002 (per each year), and the use of diuretics (ORa 2.54, p = 0.018) and calcium blockers (ORa 2.54, p = 0.010). On the other hand, the use of ACE inhibitors was associated with a marked reduction of in-hospital death (ORa 0.44, p = 0.045). 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The potential value of these drugs when hypertensive patients suffer an acute myocardial infarction (AMI) has, however, not been fully elucidated. The objective of the present observational study was to investigate whether prior use of different antihypertensive drugs could modify or influence in-hospital death in hypertensives suffering an AMI. A total of 299 hypertensive patients with the diagnosis of AMI were included. The demographic data were obtained from medical records. Variables were entered into a logistic regression model. The main predictors of death were age (adjusted odds ratio (ORa) 1.07, p = 0.002 (per each year), and the use of diuretics (ORa 2.54, p = 0.018) and calcium blockers (ORa 2.54, p = 0.010). On the other hand, the use of ACE inhibitors was associated with a marked reduction of in-hospital death (ORa 0.44, p = 0.045). The present study indicates that while the use of ACE inhibitors was associated with a reduced risk of in-hospital death in hypertensive patients suffering an AMI, the use of diuretics and calcium blockers was associated with increased risks.","publication_date":{"day":null,"month":null,"year":2003,"errors":{}},"publication_name":"Blood Pressure"},"translated_abstract":"Several studies, which have compared the efficacy of conventional antihypertensive drugs (thiazide diuretics and beta-blockers) with the newer agents [calcium blockers and angiotensin-converting enzyme (ACE) inhibitors], have shown that they are almost equally efficacious with regard to effects on blood pressure, and in preventing cardiovascular morbidity and mortality. The potential value of these drugs when hypertensive patients suffer an acute myocardial infarction (AMI) has, however, not been fully elucidated. The objective of the present observational study was to investigate whether prior use of different antihypertensive drugs could modify or influence in-hospital death in hypertensives suffering an AMI. A total of 299 hypertensive patients with the diagnosis of AMI were included. The demographic data were obtained from medical records. Variables were entered into a logistic regression model. The main predictors of death were age (adjusted odds ratio (ORa) 1.07, p = 0.002 (per each year), and the use of diuretics (ORa 2.54, p = 0.018) and calcium blockers (ORa 2.54, p = 0.010). On the other hand, the use of ACE inhibitors was associated with a marked reduction of in-hospital death (ORa 0.44, p = 0.045). The present study indicates that while the use of ACE inhibitors was associated with a reduced risk of in-hospital death in hypertensive patients suffering an AMI, the use of diuretics and calcium blockers was associated with increased risks.","internal_url":"https://www.academia.edu/30192866/Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality","translated_internal_url":"","created_at":"2016-12-01T00:31:01.119-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57388409,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Antihypertensive_Therapy_at_the_Onset_of_an_Acute_Myocardial_Infarction_Predicts_In_hospital_Mortality","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57388409,"first_name":"Elena","middle_initials":null,"last_name":"Kvan","page_name":"ElenaKvan","domain_name":"independent","created_at":"2016-11-29T03:21:04.484-08:00","display_name":"Elena Kvan","url":"https://independent.academia.edu/ElenaKvan"},"attachments":[],"research_interests":[{"id":41482,"name":"Multivariate Analysis","url":"https://www.academia.edu/Documents/in/Multivariate_Analysis"},{"id":88321,"name":"Blood Pressure","url":"https://www.academia.edu/Documents/in/Blood_Pressure"},{"id":89995,"name":"Diuretics","url":"https://www.academia.edu/Documents/in/Diuretics"},{"id":194640,"name":"Patient Admission","url":"https://www.academia.edu/Documents/in/Patient_Admission"},{"id":195985,"name":"Aspirin","url":"https://www.academia.edu/Documents/in/Aspirin"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":289271,"name":"Aged","url":"https://www.academia.edu/Documents/in/Aged"},{"id":378016,"name":"Myocardial Infarction","url":"https://www.academia.edu/Documents/in/Myocardial_Infarction"},{"id":400209,"name":"Warfarin","url":"https://www.academia.edu/Documents/in/Warfarin"},{"id":413194,"name":"Analysis of Variance","url":"https://www.academia.edu/Documents/in/Analysis_of_Variance"},{"id":413195,"name":"Time Factors","url":"https://www.academia.edu/Documents/in/Time_Factors"},{"id":424295,"name":"Survival Rate","url":"https://www.academia.edu/Documents/in/Survival_Rate"},{"id":469105,"name":"Retrospective Studies","url":"https://www.academia.edu/Documents/in/Retrospective_Studies"},{"id":901284,"name":"Hospital Mortality","url":"https://www.academia.edu/Documents/in/Hospital_Mortality"},{"id":1200766,"name":"Drug Utilization","url":"https://www.academia.edu/Documents/in/Drug_Utilization"},{"id":1227768,"name":"Angiotensin Converting Enzyme Inhibitors","url":"https://www.academia.edu/Documents/in/Angiotensin_Converting_Enzyme_Inhibitors"},{"id":1954221,"name":"Calcium Channel Blockers","url":"https://www.academia.edu/Documents/in/Calcium_Channel_Blockers"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="30032335"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/30032335/Pharmacology_Portal_An_Open_Database_for_Clinical_Pharmacologic_Laboratory_Services"><img alt="Research paper thumbnail of Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/30032335/Pharmacology_Portal_An_Open_Database_for_Clinical_Pharmacologic_Laboratory_Services">Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://idv.academia.edu/AndreasWestin">Andreas Westin</a>, <a class="" data-click-track="profile-work-strip-authors" href="https://uio.academia.edu/ThorHilberg">Thor Hilberg</a>, and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/ElenaKvan">Elena Kvan</a></span></div><div class="wp-workCard_item"><span>Clinical Therapeutics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">More than 50 Norwegian public and private laboratories provide one or more analyses for therapeut...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">More than 50 Norwegian public and private laboratories provide one or more analyses for therapeutic drug monitoring or testing for drugs of abuse. Practices differ among laboratories, and analytical repertoires can change rapidly as new substances become available for analysis. The Pharmacology Portal was developed to provide an overview of these activities and to standardize the practices and terminology among laboratories. The Pharmacology Portal is a modern dynamic web database comprising all available analyses within therapeutic drug monitoring and testing for drugs of abuse in Norway. Content can be retrieved by using the search engine or by scrolling through substance lists. The core content is a substance registry updated by a national editorial board of experts within the field of clinical pharmacology. This ensures quality and consistency regarding substance terminologies and classification. All laboratories publish their own repertoires in a user-friendly workflow, adding laboratory-specific details to the core information in the substance registry. The user management system ensures that laboratories are restricted from editing content in the database core or in repertoires within other laboratory subpages. The portal is for nonprofit use, and has been fully funded by the Norwegian Medical Association, the Norwegian Society of Clinical Pharmacology, and the 8 largest pharmacologic institutions in Norway. The database server runs an open-source content management system that ensures flexibility with respect to further development projects, including the potential expansion of the Pharmacology Portal to other countries.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="30032335"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="30032335"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 30032335; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=30032335]").text(description); $(".js-view-count[data-work-id=30032335]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 30032335; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='30032335']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 30032335, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=30032335]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":30032335,"title":"Pharmacology Portal: An Open Database for Clinical Pharmacologic Laboratory Services","translated_title":"","metadata":{"abstract":"More than 50 Norwegian public and private laboratories provide one or more analyses for therapeutic drug monitoring or testing for drugs of abuse. 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