CINXE.COM

<!DOCTYPE html> <html class="no-js" lang="en" prefix="og: https://ogp.me/ns#"> <head> <script src="https://sp-library.prod.sp.aws.clarivate.net/oti/latest/index.umd.js"></script> <link href="https://www.bioworld.com/topics/520-bioworld-science" rel="canonical"> <meta charset="utf-8"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="l3gAPQif+hyiF4pfMACGvEH/pkxVqHMWKC0/I5QkIftsYdIeo2V7yXj3NeXnnZZgOw7zOaaYnSLRPPu/PB9bPA==" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta name="timestamp" value="2025-02-20 00:22:25 -0500"> <meta name="description" content="Daily news focused on drug discovery, delivery and preclinical research. Coverage includes: Congress highlights, key studies from peer-reviewed journals, chemical structure images, pharmacology news that delineates drug/receptor and enzyme/target cell interactions, newly reported experimental models, and relationships between genes and diseases to gain insight into underlying biological mechanisms and identify potential new drug targets" /> <meta name="keywords" content="news, patents, congress, biotech, biotechnology, pharma, pharmaceutical, R&D, drugs, drug research, health, cancer, preclinical, financing, science, IND, partnerships, collaborations" /> <link rel="alternate" type="application/xml" title="BioWorld RSS Feed" href="https://www.bioworld.com/rss/articles" /> <meta property="og:title" /> <meta property="og:description" /> <meta property="og:url" /> <meta property="og:type" content="Website" /> <meta content="false" name="has-log-view" /> <title>BioWorld Science: The Daily Drug R&D News Source</title> <link rel="stylesheet" media="screen" href="/stylesheets/application.css?v=1740028945" /> <script src="/javascripts/jade.default.min.js?v=1740028945"></script> <script src="/javascripts/application.js?v=1740028945"></script>  <script>var dataLayer = window.dataLayer || [];</script> <script>let snowplowData = {"event":"SnowplowStructuredEvent","product":"BIOWORLD_SCIENCE"}; fetch('/user/snowplow', { method: 'GET', headers: { 'Content-Type': 'application/json' } }) .then(response => { if (!response.ok) { throw new Error(`HTTP error! status: ${response.status}`); } return response.json(); }) .then(data => { const evt = Object.assign({}, snowplowData, data); console.info('Snowplow Data:', evt); // Handle the fetched data dataLayer.push(evt); }) .catch(error => { console.error('Error fetching snowplow data:', error); // Handle any errors });</script><script>dataLayer.push({"id":520,"topics":["BioWorld Science"],"title":"BioWorld Science","page_type":["topics"],"date_posted":"07/06/2020","gated":false,"registered":false});</script> <script>typeof window.dataLayer[0] === 'object' && !('page_type' in window.dataLayer[0]) && window.dataLayer.push({"id":520,"topics":["BioWorld Science"],"title":"BioWorld Science","page_type":["topics"],"date_posted":"07/06/2020","gated":false,"registered":false});</script>   <script> //<![CDATA[ (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= '//www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-5ZV86V9'); //]]> </script>  <script> window.epub = window.epub || {}; window.epub['AD_HISTORY_ENABLED'] = false; </script> <link rel="apple-touch-icon" sizes="180x180" href="/icons/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="/icons/favicon-32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="/icons/favicon-16x16.png"> <link rel="manifest" href="/icons/site.webmanifest"> <link rel="mask-icon" href="/icons/safari-pinned-tab.svg" color="#5bbad5"> <link rel="shortcut icon" href="/icons/favicon.ico"> <meta name="msapplication-TileColor" content="#00aba9"> <meta name="msapplication-config" content="/icons/browserconfig.xml"> <meta name="theme-color" content="#ffffff"><script> var googletag = { cmd: [] }; var targeting = window.targeting = {"id":"520","tags":["BioWorld Science"],"taxonomy":["BioWorld Science"],"taxonomy_id":[520],"sponsored":"false","page_type":["topics"],"keyword":[],"reg_user":"false","page_name":"520-bioworld-science","search_terms":"","url":"/topics/520-bioworld-science","site_env":"production"}; </script> <script> (function(ac) { var d = document, s = 'script', id = 'adplugg-adjs'; var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) return; js = d.createElement(s); js.id = id; js.async = 1; js.src = '//www.adplugg.com/serve/' + ac + '/js/1.1/ad.js'; fjs.parentNode.insertBefore(js, fjs); }('A48225833')); </script><script>if (typeof Oti !== "undefined" && typeof Oti.OtiService !== "undefined") { $.post('/user/pendo', function(data) { const pendoVisitor = data.visitor const pendoAccount = Object.keys(pendoVisitor).length > 0 ? data.account : '' const anomID = localStorage.getItem('anomID') || (localStorage.setItem('anomID', `${navigator.userAgent}-${screen.width}x${screen.height}-${navigator.language}`.split('').reduce((hash, char) => ((hash << 5) - hash) + char.charCodeAt(0), 0).toString(36)) || localStorage.getItem('anomID')) const pendovistorID = (pendoVisitor && Object.keys(pendoVisitor).length > 0 && pendoVisitor.id) ? `${pendoVisitor.id}` : anomID; const otiService = new Oti.OtiService({ ot_key: "603e2c5b-3a1d-4eac-a9c9-fb20c3b528f2", prod_domain: "www.bioworld.com", pendo_key: "34b78be2-b210-4df9-7f2b-7552afe5341c", pendo_details: { visitor: { id: pendovistorID, firstName: pendoVisitor.first_name, lastName: pendoVisitor.last_name, email: pendoVisitor.email, country: pendoVisitor.country, company: pendoVisitor.company, last_login: pendoVisitor.last_login, opted_out_at: pendoVisitor.opted_out_at, }, account: { id: pendoAccount } }, pendo_visitor_payload: [{ visitorId: pendovistorID, values: { firstName: pendoVisitor.first_name, lastName: pendoVisitor.last_name, email: pendoVisitor.email, country: pendoVisitor.country, company: pendoVisitor.company, last_login: pendoVisitor.last_login, opted_out_at: pendoVisitor.opted_out_at, } }], pendo_visitor_url: '/ui/pendoapi/agent/value?create=true', pendo_dnp_url: `/ui/pendoapi/pendo/value/${pendovistorID}/donotprocess`, pendo_metadata_url: `/ui/pendoapi/custom/value/${pendovistorID}/bioworld_targetingcookies`, }); otiService.initialize(); }); }</script> <link rel="preload" as="script" href="https://cdn.ampproject.org/v0.js"> <script async src="https://cdn.ampproject.org/v0.js"></script>  <style amp-custom>/* Add your styles here */</style> <style amp-boilerplate>body{-webkit-animation:-amp-start 8s steps(1,end) 0s 1 normal both;-moz-animation:-amp-start 8s steps(1,end) 0s 1 normal both;-ms-animation:-amp-start 8s steps(1,end) 0s 1 normal both;animation:-amp-start 8s steps(1,end) 0s 1 normal both}@-webkit-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@-moz-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@-ms-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@-o-keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}@keyframes -amp-start{from{visibility:hidden}to{visibility:visible}}</style><noscript><style amp-boilerplate>body{-webkit-animation:none;-moz-animation:none;-ms-animation:none;animation:none}</style></noscript> <link rel="canonical" href="."> <script async custom-element="amp-iframe" src="https://cdn.ampproject.org/v0/amp-iframe-0.1.js"></script> <script>var _document$querySelect, _document$querySelect2; var $hasLogViewMeta = (_document$querySelect = document.querySelector('meta[name=has-log-view]')) === null || _document$querySelect === void 0 ? void 0 : _document$querySelect.getAttribute('content'); var $logViewUrlMeta = (_document$querySelect2 = document.querySelector('meta[name=log-view-url]')) === null || _document$querySelect2 === void 0 ? void 0 : _document$querySelect2.getAttribute('content'); if ($hasLogViewMeta === 'true') { var baseLogUrl = (typeof $logViewUrlMeta === "undefined" ? window.location.pathname : $logViewUrlMeta).replace(/(\d+)-.*$/, '$1'); var logUrl = baseLogUrl + '/log_view' + window.location.search; if (typeof navigator.sendBeacon === 'function') { navigator.sendBeacon(logUrl); } else { // Gotta love IE var request = new XMLHttpRequest(); request.open('POST', logUrl, true); request.setRequestHeader('Content-Type', 'application/x-www-form-urlencoded; charset=UTF-8'); request.send(); } }</script> </head> <body data-controller="taxonomies" data-action="show" data-prestitial-ad="false" data-poststitial-ad="false" data-news-services="BIOWORLD_SCIENCE">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5ZV86V9" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>  <div class="document mmenu-placeholder"><header class="main-header"><div class="main-header__top"><h1> <a href="/" class="main-header__logo" data-eventaction="logo-link" data-eventcategory="click" data-eventlabel="link to homepage" data-eventname="logo-link"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 201 36" height="36" fill="none" preservAspectRatio="xMidYMid meet"> <title>BioWorld. Link to homepage.</title> <path fill="#000" d="M17.7999 16.5745v.1066c3.8891 1.5805 6.2511 4.4219 6.2511 8.3111 0 5.3809-3.9958 9.6608-11.0993 9.6608H1V1.01776h10.8506c6.9082 0 10.3712 4.27988 10.3712 8.59527 0 2.93017-1.4385 5.57627-4.4219 6.96147zM7.67732 6.68283v7.49427H11.087c2.3975 0 4.3687-1.2076 4.3687-3.8004 0-2.59283-2.06-3.69387-4.3687-3.69387H7.67732zm0 22.34057h3.46298c4.0313 0 5.9492-1.8646 5.9492-4.6173 0-2.8414-2.3619-4.2798-5.6118-4.2798H7.67732v8.8971zM35.239 34.6352h-6.2333v-16.711h-3.0723V12.632h9.3056v22.0032zM31.8293 1.01776c2.2554 0 4.0313 1.82916 4.0313 4.03125 0 2.25538-1.7759 3.97798-4.0313 3.97798-2.2021 0-3.9957-1.7226-3.9957-3.97798.0178-2.20209 1.7936-4.03125 3.9957-4.03125zM39.217 23.6425c0-6.7128 5.2389-11.5787 11.7564-11.5787 6.5175 0 11.7563 4.8481 11.7563 11.5787s-5.2388 11.5788-11.7563 11.5788c-6.5175 0-11.7564-4.8659-11.7564-11.5788zm6.2511 0c0 3.4097 2.2554 6.0025 5.523 6.0025 3.2144 0 5.4697-2.5928 5.4697-6.0025 0-3.463-2.2553-6.0025-5.4697-6.0025-3.2676 0-5.523 2.5395-5.523 6.0025zM88.7286 1.01776L95.1573 25.081h.0533l5.3814-24.06324h6.819L99.2064 34.6352h-7.7251l-6.3399-24.152-6.1979 24.152h-7.7251L62.9073 1.01776h7.2101L75.303 25.081h.0532l6.4287-24.06324h6.9437zM106.701 23.6425c0-6.7128 5.238-11.5787 11.756-11.5787 6.535 0 11.756 4.8481 11.756 11.5787s-5.239 11.5788-11.756 11.5788c-6.535-.0178-11.756-4.8659-11.756-11.5788zm6.233 0c0 3.4097 2.255 6.0025 5.523 6.0025 3.214 0 5.47-2.5928 5.47-6.0025 0-3.463-2.256-6.0025-5.47-6.0025-3.268 0-5.523 2.5395-5.523 6.0025zm34.772-4.8481h-2.646c-3.161 0-4.618 1.4917-4.618 5.3276v10.5132h-6.233V12.632h6.056v3.4985c.87-2.3441 2.983-3.8004 5.718-3.8004.586 0 1.154.0533 1.723.1954v6.2689zm9.696 15.8408h-6.198V1.01776h6.198V34.6352zm21.559-2.7881c-1.101 1.8292-3.694 3.3564-6.872 3.3564-6.056 0-10.656-4.8481-10.656-11.5787s4.564-11.5788 10.62-11.5788c3.357 0 5.914 1.545 7.015 3.4097 0-.7281-.089-2.5395-.089-4.1733V1h6.233v33.6175h-6.233v-2.7704h-.018zm-11.081-8.2046c0 3.3564 2.308 6.0558 5.612 6.0558 3.303 0 5.611-2.6994 5.611-6.0558 0-3.4097-2.308-6.0025-5.611-6.0025-3.304 0-5.612 2.5928-5.612 6.0025zM191.801 2.58054h2.06V1.01776h-5.772v1.56278h2.043V6.8249h1.669V2.58054zM201 6.8249V1.01776h-2.184l-1.119 2.84141-1.101-2.84141h-2.22V6.8249h1.652V3.13106l1.101 2.66382h1.065l1.101-2.68158v3.7116H201z"/> </svg> </a> </h1><a href='https://clarivate.com/cortellis/' target="_blank" class="main-header__logo -clarivate"> <img src="/images/Cortellis_Flagship_Logo.png" alt="Clarivate" title="Powering insights from Cortellis. Link to Cortellis page on Clarivate website."> </a></div><div class="main-nav-container"><div class="main-nav-container__wrapper"><nav id="main-nav" class="main-nav main-nav--horizontal"><div class="navigation"><ul class="main-nav-level1__items"><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld|/topics/84-bioworld" href="/topics/84-bioworld">BioWorld</a></li><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld MedTech|/topics/85-bioworld-medtech" href="/topics/85-bioworld-medtech">BioWorld MedTech</a></li><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld Asia|/topics/86-bioworld-asia" href="/topics/86-bioworld-asia">BioWorld Asia</a></li><li class="main-nav-level1__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld Science|/topics/520-bioworld-science" href="/topics/520-bioworld-science">BioWorld Science</a></li><li class="main-nav-level1__item"><a class="main-nav__link -has-children" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Data Snapshots|/snapshots" href="/snapshots">Data Snapshots</a><ul class="main-nav-level2__items"><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld|/snapshots" href="/snapshots">BioWorld</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld MedTech|/medtech_snapshots" href="/medtech_snapshots">BioWorld MedTech</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Infographics: Dynamic digital data analysis|/infographics-index" href="/infographics-index">Infographics: Dynamic digital data analysis</a></li></ul></li><li class="main-nav-level1__item"><a class="main-nav__link -has-children" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Special reports|/special_reports" href="/special_reports">Special reports</a><ul class="main-nav-level2__items"><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Infographics: Dynamic digital data analysis|/infographics-index" href="/infographics-index">Infographics: Dynamic digital data analysis</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Trump administration impacts|/Trump_administration_impacts" href="/Trump_administration_impacts">Trump administration impacts</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Biopharma M&A scorecard|/biopharma_MandA_scorecard" href="/biopharma_MandA_scorecard">Biopharma M&A scorecard</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld 2024 review|/BioWorld_2024_review" href="/BioWorld_2024_review">BioWorld 2024 review</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld MedTech 2024 review|https://www.bioworld.com/medtech_trends_2024" href="https://www.bioworld.com/medtech_trends_2024">BioWorld MedTech 2024 review</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="BioWorld Science 2024 review|/BioWorld_Science_2024_review" href="/BioWorld_Science_2024_review">BioWorld Science 2024 review</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Women's health|/womens_health" href="/womens_health">Women's health</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="China's GLP-1 landscape|/China_GLP-1" href="/China_GLP-1">China's GLP-1 landscape</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="PFA re-energizes afib market|https://www.bioworld.com/articles/711618-pulsed-field-ablation-re-energizes-the-atrial-fibrillation-market" href="https://www.bioworld.com/articles/711618-pulsed-field-ablation-re-energizes-the-atrial-fibrillation-market">PFA re-energizes afib market</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="China CAR T|/China_CAR_T" href="/China_CAR_T">China CAR T</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Alzheimer's disease|/Alzheimers" href="/Alzheimers">Alzheimer's disease</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Israel|/israel" href="/israel">Israel</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Rise of obesity|/rise_of_obesity" href="/rise_of_obesity">Rise of obesity</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Radiopharmaceuticals|/radiopharmaceuticals" href="/radiopharmaceuticals">Radiopharmaceuticals</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Biosimilars|/biosimilars" href="/biosimilars">Biosimilars</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Aging|/aging" href="/aging">Aging</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="IVDs on the rise|/IVDs-2021" href="/IVDs-2021">IVDs on the rise</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Coronavirus|/articles/topic/517" href="/articles/topic/517">Coronavirus</a></li><li class="main-nav-level2__item"><a class="main-nav__link" data-eventname="main-nav" data-eventcategory="click" data-eventaction="main-nav-link" data-eventlabel="Artificial intelligence|/AI_series" href="/AI_series">Artificial intelligence</a></li></ul></li></ul></div></nav><div class="main-nav-container__mobile-nav"><a class="hamburger-nav-link" href="#" id="hamburger-nav-link"></a><h1> <a href="/" class="main-header__logo" data-eventaction="logo-link" data-eventcategory="click" data-eventlabel="link to homepage" data-eventname="logo-link"> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 201 36" height="36" fill="none" preservAspectRatio="xMidYMid meet"> <title>BioWorld. Link to homepage.</title> <path fill="#000" d="M17.7999 16.5745v.1066c3.8891 1.5805 6.2511 4.4219 6.2511 8.3111 0 5.3809-3.9958 9.6608-11.0993 9.6608H1V1.01776h10.8506c6.9082 0 10.3712 4.27988 10.3712 8.59527 0 2.93017-1.4385 5.57627-4.4219 6.96147zM7.67732 6.68283v7.49427H11.087c2.3975 0 4.3687-1.2076 4.3687-3.8004 0-2.59283-2.06-3.69387-4.3687-3.69387H7.67732zm0 22.34057h3.46298c4.0313 0 5.9492-1.8646 5.9492-4.6173 0-2.8414-2.3619-4.2798-5.6118-4.2798H7.67732v8.8971zM35.239 34.6352h-6.2333v-16.711h-3.0723V12.632h9.3056v22.0032zM31.8293 1.01776c2.2554 0 4.0313 1.82916 4.0313 4.03125 0 2.25538-1.7759 3.97798-4.0313 3.97798-2.2021 0-3.9957-1.7226-3.9957-3.97798.0178-2.20209 1.7936-4.03125 3.9957-4.03125zM39.217 23.6425c0-6.7128 5.2389-11.5787 11.7564-11.5787 6.5175 0 11.7563 4.8481 11.7563 11.5787s-5.2388 11.5788-11.7563 11.5788c-6.5175 0-11.7564-4.8659-11.7564-11.5788zm6.2511 0c0 3.4097 2.2554 6.0025 5.523 6.0025 3.2144 0 5.4697-2.5928 5.4697-6.0025 0-3.463-2.2553-6.0025-5.4697-6.0025-3.2676 0-5.523 2.5395-5.523 6.0025zM88.7286 1.01776L95.1573 25.081h.0533l5.3814-24.06324h6.819L99.2064 34.6352h-7.7251l-6.3399-24.152-6.1979 24.152h-7.7251L62.9073 1.01776h7.2101L75.303 25.081h.0532l6.4287-24.06324h6.9437zM106.701 23.6425c0-6.7128 5.238-11.5787 11.756-11.5787 6.535 0 11.756 4.8481 11.756 11.5787s-5.239 11.5788-11.756 11.5788c-6.535-.0178-11.756-4.8659-11.756-11.5788zm6.233 0c0 3.4097 2.255 6.0025 5.523 6.0025 3.214 0 5.47-2.5928 5.47-6.0025 0-3.463-2.256-6.0025-5.47-6.0025-3.268 0-5.523 2.5395-5.523 6.0025zm34.772-4.8481h-2.646c-3.161 0-4.618 1.4917-4.618 5.3276v10.5132h-6.233V12.632h6.056v3.4985c.87-2.3441 2.983-3.8004 5.718-3.8004.586 0 1.154.0533 1.723.1954v6.2689zm9.696 15.8408h-6.198V1.01776h6.198V34.6352zm21.559-2.7881c-1.101 1.8292-3.694 3.3564-6.872 3.3564-6.056 0-10.656-4.8481-10.656-11.5787s4.564-11.5788 10.62-11.5788c3.357 0 5.914 1.545 7.015 3.4097 0-.7281-.089-2.5395-.089-4.1733V1h6.233v33.6175h-6.233v-2.7704h-.018zm-11.081-8.2046c0 3.3564 2.308 6.0558 5.612 6.0558 3.303 0 5.611-2.6994 5.611-6.0558 0-3.4097-2.308-6.0025-5.611-6.0025-3.304 0-5.612 2.5928-5.612 6.0025zM191.801 2.58054h2.06V1.01776h-5.772v1.56278h2.043V6.8249h1.669V2.58054zM201 6.8249V1.01776h-2.184l-1.119 2.84141-1.101-2.84141h-2.22V6.8249h1.652V3.13106l1.101 2.66382h1.065l1.101-2.68158v3.7116H201z"/> </svg> </a> </h1><a class="search-nav-link" href="#" id="search-nav-link"></a><form action="/search" class="mobile-search" id="mobile-search" method="get"><input class="mobile-search__field" name="q" placeholder="What are you looking for?" type="text" /><button class="mobile-search__icon" type="submit"></button></form></div><div class="main-nav-container__nav2"><nav class="user-actions" id="user-actions"> <ul class="user-actions__list"> <li class="user-actions__signin"> <a class="user-actions__signin-link" href="/user/login">Sign In</a> </li> <li class="user-actions__signout"> <a class="user-actions__signout-link" href="/user/logout">Sign Out</a> </li> <li class="user-actions__account"> <a class="user-actions__account-link" href="/user/profile">My Account</a> </li> </ul> </nav> <a class="main-nav-container__subscribe-link" href="/subscriptions">Subscribe</a><div class="quick-search" id="quick-search"><form action="/search" id="quick-search-form" method="GET" name="quick-search" target="_top"><div class="quick-search__wrapper" role="presentation"><input class="quick-search__search-field" id="q" name="q" placeholder="Search" type="text" /><button class="quick-search__button" title="Search" type="submit"></button></div></form></div></div></div></div></header><div class="container container-full"><section class="site-banner" id="site-banner"><div class="site-banner__date">BioWorld - Thursday, February 20, 2025</div><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_SCIENCE" target="_blank" href="https://clarivate.com/news/bioworld-by-clarivate-releases-comprehensive-2024-year-in-review/">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_MEDTECH" href="/articles/717493-five-med-tech-trends-to-watch-in-2025">Breaking News: Five med-tech trends to watch in 2025</a><a class="site-banner__breaking-news" id="BREAKING_BIOWORLD_ASIA" href="/articles/716554-bioworld-by-clarivate-releases-comprehensive-2024-year-in-review">Breaking News: BioWorld by Clarivate releases comprehensive 2024 year in review</a></section><section class="featured-stories__wrapper -primary-5 --secondary-4"><div class="featured-stories__primary "><section class="featured-stories "> <div class="featured-stories__items-wrapper"><ul class="featured-stories__items featured-stories__items-1"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><figure class="featured-stories__image"><a class="featured-stories__thumbnail-link" data-eventname="featured-stories" data-eventcategory="click" data-eventaction="featured-stories-image" data-eventlabel="https://www.bioworld.com/articles/717368-guk1-is-metabolic-gate-in-alk-driven-lung-cancer" href="https://www.bioworld.com/articles/717368-guk1-is-metabolic-gate-in-alk-driven-lung-cancer"><img class="featured-stories__image-thumb" alt="Lung cancer illustration" title="Lung cancer illustration" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/lung-cancer.png?height=355&t=1588884954&width=640" /></a></figure><div class="featured-stories__details featured-stories__details-1"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717368-guk1-is-metabolic-gate-in-alk-driven-lung-cancer">GUK1 is metabolic gate in ALK-driven lung cancer</a></h1><div class="featured-stories__teaser">Using ALK+ lung cancer patient-derived cell lines, researchers have performed phosphoproteomic screening and identified guanylate kinase 1 (GUK1) as a TKI sensitive metabolic molecule in ALK-driven lung cancer. They reported their results online in <em>Cell</em> on Feb. 6, 2025.</div></div></article> </li> </ul><ul class="featured-stories__items featured-stories__items-2"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717667-aaas-2025-former-nih-head-bertagnolli-sounds-warning-on-funding-cuts">AAAS 2025: Former NIH head Bertagnolli sounds warning on funding cuts</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717370-perceive-pharma-secures-series-a-for-ophthalmic-diseases">Perceive Pharma secures Series A for ophthalmic diseases</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717371-intranasal-bacterium-for-targeted-brain-delivery">Intranasal bacterium for targeted brain delivery</a></h1></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717372-dod-funding-supports-kairos-pharmas-env-205">DoD funding supports Kairos Pharma’s ENV-205 </a></h1></article> </li> </ul></div> </section></div><div class="featured-stories__secondary"><section class="featured-stories "> <ul class="featured-stories__items"> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717368-guk1-is-metabolic-gate-in-alk-driven-lung-cancer">GUK1 is metabolic gate in ALK-driven lung cancer</a></h1><div class="featured-stories__teaser">Using ALK+ lung cancer patient-derived cell lines, researchers have performed phosphoproteomic screening and identified guanylate kinase 1 (GUK1) as a TKI sensitive metabolic molecule in ALK-driven lung cancer. They reported their results online in <em>Cell</em> on Feb. 6, 2025.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717667-aaas-2025-former-nih-head-bertagnolli-sounds-warning-on-funding-cuts">AAAS 2025: Former NIH head Bertagnolli sounds warning on funding cuts</a></h1><div class="featured-stories__teaser">The former head of the U.S. NIH has sounded a warning that the uncertainty caused by the Trump Administration’s funding cuts and layoffs is blocking “critical work” and “paralyzing” biomedical research. “Every time we launch a new program, every time we continue to commit resources to ongoing work, those are important decisions that we make every single day, and in times like this, that decision-making is paralyzed,” said Monica Bertagnolli, who stood down as director of the NIH on Jan. 17.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717370-perceive-pharma-secures-series-a-for-ophthalmic-diseases">Perceive Pharma secures Series A for ophthalmic diseases</a></h1><div class="featured-stories__teaser">Perceive Pharma Inc., a spin out from Perceive Biotherapeutics Inc., has closed a $15 million series A funding round to help it advance first-in-class therapies to prevent vision loss in glaucoma, and additional undisclosed disease areas.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717371-intranasal-bacterium-for-targeted-brain-delivery">Intranasal bacterium for targeted brain delivery</a></h1><div class="featured-stories__teaser">In a recent publication in <em>Cell</em>, researchers from the National University of Singapore and collaborators have proposed using commensal bacteria in the nasal cavity as a delivery vector for precision therapy targeting the OE and brain.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717372-dod-funding-supports-kairos-pharmas-env-205">DoD funding supports Kairos Pharma’s ENV-205 </a></h1><div class="featured-stories__teaser">Kairos Pharma Ltd. has announced that through its academic partnership with Cedars-Sinai Medical Center, Cedars-Sinai has received $600,000 in funding from the Department of Defense lung cancer research program to advance the development of ENV-205, a new drug to treat chemotherapy drug resistance and cachexia.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article -has-image featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717493-five-med-tech-trends-to-watch-in-2025">Five med-tech trends to watch in 2025</a></h1><div class="featured-stories__teaser">The Clarivate Medtech Trends to Watch in 2024 report noted the resilience of the medtech sector in the face of changing macroeconomic factors and the preparation required to navigate the market’s many complexities. It is likely that 2025 will be no different. </div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717544-shanghai-wennai-pharmaceutical-technology-patents-new-nav18-blockers">Shanghai Wennai Pharmaceutical Technology patents new Nav1.8 blockers</a></h1><div class="featured-stories__teaser">Shanghai Wennai Pharmaceutical Technology Co. Ltd. has disclosed sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of acute and chronic pain.</div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717373-g-protein-coupled-receptor-kinase-is-cystic-fibrosis-target">G-protein coupled receptor kinase is cystic fibrosis target</a></h1><div class="featured-stories__teaser">Cystic fibrosis is a life-threatening disease predominantly with respiratory symptoms. Most of the subjects with the disease harbor the F508del variant in the <em>CFTR</em> gene that causes the protein to misfold and be prematurely degraded. Despite approved drugs that restore the CFTR protein, the maximal lung function improvement is approximately 14%. </div></article> </li> <li class="featured-stories__item"> <article class="featured-stories__article featured-stories--article"><h1 class="featured-stories__headline"><a class="featured-stories__article-title-link" href="https://www.bioworld.com/articles/717374-septerna-to-change-candidate-for-hypoparathyroidism">Septerna to change candidate for hypoparathyroidism </a></h1><div class="featured-stories__teaser">Septerna Inc. has announced its decision to discontinue a healthy volunteer phase I trial of SEP-786, an oral small-molecule agonist of the parathyroid hormone 1 receptor being developed for the treatment of hypoparathyroidism.</div></article> </li> </ul> </section></div><div class="news-service articles-by-site-placement-tax"><section class="featured-stories-by-site-placement__wrapper"><section class="featured-stories-by-site-placement "> <div class="featured-stories-by-site-placement__items-wrapper"><ul class="featured-stories-by-site-placement__items featured-stories-by-site-placement__items-1"> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717375-camelid-based-car-t-cells-targeting-cd33-in-acute-myeloid-leukemia">Camelid-based CAR T cells targeting CD33 in acute myeloid leukemia</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/717375-camelid-based-car-t-cells-targeting-cd33-in-acute-myeloid-leukemia" href="https://www.bioworld.com/articles/717375-camelid-based-car-t-cells-targeting-cd33-in-acute-myeloid-leukemia"><img class="featured-stories-by-site-placement__image-thumb" alt="Three alpacas" title="Three alpacas" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-source/Biondvax-Alpacas-hero.png?height=146&t=1669823736&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717545-beijing-synthetic-vaccine-biosciences-divulges-new-tlr8-agonists">Beijing Synthetic Vaccine Biosciences divulges new TLR8 agonists</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717548-shenzhen-zhongge-biotechnology-describes-new-eif2b-activators">Shenzhen Zhongge Biotechnology describes new EIF2B activators</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717376-kvx-053-alleviates-acute-lung-injury-in-covid-19">KVX-053 alleviates acute lung injury in COVID-19</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/717376-kvx-053-alleviates-acute-lung-injury-in-covid-19" href="https://www.bioworld.com/articles/717376-kvx-053-alleviates-acute-lung-injury-in-covid-19"><img class="featured-stories-by-site-placement__image-thumb" alt="Novel coronavirus SARS-CoV-2" title="Novel coronavirus SARS-CoV-2" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Infectious/Novel-Coronavirus-SARS-CoV-2.png?height=146&t=1606948594&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717377-ona-advances-adcs-for-solid-tumors-toward-clinic">Ona advances ADCs for solid tumors toward clinic</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717546-new-cyp11b2-inhibitors-disclosed-in-hansoh-patent">New CYP11B2 inhibitors disclosed in Hansoh patent</a></h1></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article -has-image featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717378-integrin-51-is-target-for-pulmonary-arterial-hypertension">Integrin α5β1 is target for pulmonary arterial hypertension</a></h1><figure class="featured-stories-by-site-placement__image"><a class="featured-stories-by-site-placement__thumbnail-link" data-eventname="featured-stories-by-site-placement" data-eventcategory="click" data-eventaction="featured-stories-by-site-placement-image" data-eventlabel="https://www.bioworld.com/articles/717378-integrin-51-is-target-for-pulmonary-arterial-hypertension" href="https://www.bioworld.com/articles/717378-integrin-51-is-target-for-pulmonary-arterial-hypertension"><img class="featured-stories-by-site-placement__image-thumb" alt="Cardiovascular illustration" title="Cardiovascular illustration" width="193" height="146" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cardiovascular/Cardiovascular-illustration.png?height=146&t=1654725430&width=193" /></a></figure></div></article> </li> <li class="featured-stories-by-site-placement__item"> <article class="featured-stories-by-site-placement__article featured-stories-by-site-placement--article"><div class="featured-stories-by-site-placement__details featured-stories-by-site-placement__details-0"><h1 class="featured-stories-by-site-placement__headline"><a class="featured-stories-by-site-placement__article-title-link" href="https://www.bioworld.com/articles/717547-haisco-pharmaceutical-discovers-new-wrn-inhibitors">Haisco Pharmaceutical discovers new WRN inhibitors</a></h1></div></article> </li> </ul></div> </section></section></div></section><div class="topic-podcast"><div class="adplugg-tag" data-adplugg-zone="bioworld_science_banner"></div><section class="bioworld-podcasts-component"><div class="bioworld-podcasts-component__wrapper"><div class="bioworld-podcasts-component__content"><h3 class="bioworld-podcasts-component__headline"><a class="bioworld-podcasts-component__headline-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast">BioWorld Insider Podcast</a></h3><div class="bioworld-podcasts-component__body"><img src="https://www.bioworld.com/ext/resources/Podcast-files/play-circle-button.png?1718131949" style="display: inline-block; vertical-align: bottom; margin: 5px 0px 5px 5px; text-align: right; float: right; max-width: calc(100% - 5px); width: 95px;" alt="Play button" data-uuid="YTAtMTE1OTM1" align="right">The <em>BioWorld Insider</em> podcast is a monthly dive into the business and science of drug development. Conversations with CEOs and <em>BioWorld</em> analysts in the past 12 months have included a wide range of chats with experts who are shaping the future.</div><a class="bioworld-podcasts-component__link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast">Listen now</a><div class="bioworld-podcasts-component__adplugg-ad"><div class="adplugg-tag" data-adplugg-zone="bioworld_podcasts_science"></div></div></div></div></section></div><section class="topics-section__wrapper"><div class="topics-section__primary"><section class="topics-section "> <h1 class="topics-section__title"><a class="topics-section__title-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-title" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">Conferences</a></h1><ul class="topics-section__items"> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/717327-trop2-is-a-prognostic-factor-in-urachal-carcinoma" href="https://www.bioworld.com/articles/717327-trop2-is-a-prognostic-factor-in-urachal-carcinoma"><img class="topics-section__image-thumb" alt="Microscope" title="Microscope" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Microscope.png?height=355&t=1588876288&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717327-trop2-is-a-prognostic-factor-in-urachal-carcinoma">TROP2 is a prognostic factor in urachal carcinoma</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/543,520">Biomarkers</a></div><div class="topics-section__teaser">Urachal carcinoma is a rare cancer which lacks a standard drug therapy, and for which knowledge regarding its immunohistochemical features remains unclear. The aim of a recently reported investigation was finding potential markers and targets for urachal carcinoma based on antibody-drug conjugate...</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article topics-section--article"><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717321-researchers-develop-new-glioblastoma-murine-model">Researchers develop new glioblastoma murine model</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="topics-section__teaser">The research on glioblastoma requires the development of new preclinical murine models. The GL261 cell line forms glioma-like tumors in a reliable manner when transplanted intracranially, but these tumors do not completely mimic human glioblastoma. This model responds well to immune checkpoint...</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/717531-trump-administration-an-existential-threat-to-science-warns-aaas-chief" href="https://www.bioworld.com/articles/717531-trump-administration-an-existential-threat-to-science-warns-aaas-chief"><img class="topics-section__image-thumb" alt="US flag with microscope" title="US flag with microscope" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Geographic-regions/US/US-science-research-development.jpg?height=355&t=1683143558&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717531-trump-administration-an-existential-threat-to-science-warns-aaas-chief">Trump administration an existential threat to science, warns AAAS chief</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/401,520">U.S.</a></div><div class="topics-section__teaser">The scientific establishment has launched a fight back against the Trump administration and the slew of executive orders that threaten to dismantle research funding, with a warning that the next month could be critical for the future of U.S. science.</div></div></article> </li> <li class="topics-section__item"> <article class="topics-section__article -has-image topics-section--article"><figure class="topics-section__image"><a class="topics-section__thumbnail-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-image" data-eventlabel="https://www.bioworld.com/articles/717306-kairos-presents-next-generation-gitr-agonist" href="https://www.bioworld.com/articles/717306-kairos-presents-next-generation-gitr-agonist"><img class="topics-section__image-thumb" alt="Test tubes, dropper" title="Test tubes, dropper" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Test-tubes_dropper.png?height=355&t=1588881875&width=640" /></a></figure><div class="topics-section__details topics-section__details-1"><h1 class="topics-section__headline"><a class="topics-section__article-title-link" href="https://www.bioworld.com/articles/717306-kairos-presents-next-generation-gitr-agonist">Kairos presents next-generation GITR agonist</a></h1><div class="topics-section__topics"><a class="topics-section__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="topics-section__teaser">Glucocorticoid-induced tumor necrosis factor receptor (GITR) and its ligand, GITRL, are involved in immune response regulation. GITR is mainly expressed in activated T cells while GITRL is primarily found in antigen-presenting cells.</div></div></article> </li> </ul><a class="topics-section__more-link" data-eventname="topics-section" data-eventcategory="click" data-eventaction="topics-section-more-link" data-eventlabel="/articles/topic/154-conferences" href="/articles/topic/154-conferences">More in Conferences</a> </section></div><div class="topics-section__aside"><section class="news-in-brief "> <h1 class="news-in-brief__title">Today's news in brief</h1><ul class="news-in-brief__items"> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689316-respiratory">Respiratory</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689317-dermatologic">Dermatologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689318-cardiovascular">Cardiovascular</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689319-hematologic">Hematologic</a></h1></article> </li> <li class="news-in-brief__item"> <article class="news-in-brief__article news-in-brief--article"><h1 class="news-in-brief__headline"><a class="news-in-brief__article-title-link" href="https://www.bioworld.com/articles/689320-nephrology">Nephrology</a></h1></article> </li> </ul> </section></div></section><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/472-patents" href="/articles/topic/472-patents">Patents</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717336-canwell-biotech-discovers-new-antibody-drug-conjugates">Canwell Biotech discovers new antibody-drug conjugates</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717335-amp-activated-protein-kinase-111-activators-disclosed-in-shenzhen-zhongge-biotechnology-patent">AMP-activated protein kinase α1β1γ1 activators disclosed in Shenzhen Zhongge Biotechnology patent</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717334-institute-of-cancer-research-uk-describes-new-ripk1-degradation-inducers">Institute of Cancer Research UK describes new RIPK1 degradation inducers</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717333-hainan-simcere-pharmaceutical-divulges-new-protein-degradation-inducers">Hainan Simcere Pharmaceutical divulges new protein degradation inducers</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717332-gilead-sciences-patents-new-parp-7-inhibitors">Gilead Sciences patents new PARP-7 inhibitors</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717317-glenmark-pharmaceuticals-discovers-new-irak-3-degradation-inducers">Glenmark Pharmaceuticals discovers new IRAK-3 degradation inducers</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717316-aqp4-inhibitors-disclosed-in-biocells-biotech-patent">AQP4 inhibitors disclosed in Biocells Biotech patent </a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717315-bial-portela-describes-new-ox1-receptor-antagonists">Bial-Portela describes new OX1 receptor antagonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717314-2a-biosciences-divulges-new-5-ht2a-receptor-agonists">2A Biosciences divulges new 5-HT2A receptor agonists</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717313-fudan-university-patents-new-sms2-inhibitors">Fudan University patents new SMS2 inhibitors</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">Cancer</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/717326-macrophage-drug-conjugate-platform-shows-preclinical-benefits-for-solid-tumor-therapy" href="https://www.bioworld.com/articles/717326-macrophage-drug-conjugate-platform-shows-preclinical-benefits-for-solid-tumor-therapy"><img class="bioworld-biome__image-thumb" alt="Macrophage and cancer cell" title="Macrophage and cancer cell " width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Macrophage-and-cancer-cell.png?height=355&t=1628535199&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717326-macrophage-drug-conjugate-platform-shows-preclinical-benefits-for-solid-tumor-therapy">Macrophage-drug conjugate platform shows preclinical benefits for solid tumor therapy</a></h1><div class="bioworld-biome__teaser">Solid tumors are difficult to treat due to their heterogeneity and limited blood supply, which restrict the effective delivery of anticancer drugs. Macrophages are abundant in solid tumor tissues and are the only cell type actively infiltrating hypoxic tumor regions, making them a promising option...</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717325-new-inhibitor-of-the-noncanonical-nf-b-pathway-specifically-binding-to-relb-shows-antitumor-effect">New inhibitor of the noncanonical NF-κB pathway specifically binding to RelB shows antitumor effect</a></h1></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717324-kat8-inhibition-as-therapeutic-strategy-for-esophageal-cancer">KAT8 inhibition as therapeutic strategy for esophageal cancer</a></h1></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717323-a-trispecific-tribody-as-a-new-immunomodulatory-strategy">A trispecific tribody as a new immunomodulatory strategy</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/280,520">Immuno-oncology</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717322-novel-riok2-molecular-glue-degrader-divulged">Novel RIOK2 molecular glue degrader divulged</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/546,520">New compound</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/239-cancer" href="/articles/topic/239-cancer">More in Cancer</a> </section></div><div class="adplugg-tag" data-adplugg-zone="bioworld_science_promo_1"></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">Infection</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/717307-discovery-of-new-antibiotic-compounds-against-multidrug-resistant-gram-positive-pathogens" href="https://www.bioworld.com/articles/717307-discovery-of-new-antibiotic-compounds-against-multidrug-resistant-gram-positive-pathogens"><img class="clinical__image-thumb" alt="Bacteria in petri dishes" title="Bacteria in petri dishes" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Research-and-science/Bacteria-in-petri-dishes.png?height=355&t=1588874716&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717307-discovery-of-new-antibiotic-compounds-against-multidrug-resistant-gram-positive-pathogens">Discovery of new antibiotic compounds against multidrug-resistant gram-positive pathogens</a></h1><div class="clinical__teaser">Researchers from Shanxi Medical University, Nanjing Agricultural University and China Pharmaceutical University, have detailed the discovery and preclinical characterization of antibiotic candidates against multidrug-resistant gram-positive pathogens.</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717292-boronic-acid-inhibitors-restore-cefepime-efficacy-in-multidrug-resistant-kpc-producing-emk-pneumoniae-em">Boronic acid inhibitors restore cefepime efficacy in multidrug-resistant KPC-producing <em>K. pneumoniae</em></a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/117,520">Drug resistance</a></div><div class="clinical__teaser">The boronic acid transition state inhibitors S-02030 and MB-076 were strategically designed to be active against cephalosporinases and carbapenemases, especially KPC (<em>Klebsiella pneumoniae</em> carbapenemase).</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717241-gates-foundation-novo-nordisk-foundation-and-wellcome-set-sights-on-antimicrobial-resistance">Gates Foundation, Novo Nordisk Foundation and Wellcome set sights on antimicrobial resistance</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/117,520">Drug resistance</a></div><div class="clinical__teaser">The Gates Foundation, Novo Nordisk Foundation and Wellcome have announced the launch of the Gram-Negative Antibiotic Discovery Innovator (Gr-ADI), a $50 million investment that will focus on combatting antimicrobial resistance (AMR) caused by a specific range of bacteria that are among the leading...</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717239-emplasmodium-em-essential-gene-map-gives-malaria-pharmacologic-clues"><em>Plasmodium</em> essential gene map gives malaria pharmacologic clues</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/249,520">Hematologic</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717237-tb-alliance-discovers-new-clpp1p2-protease-inhibitors-for-tuberculosis">TB Alliance discovers new ClpP1P2 protease inhibitors for tuberculosis</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/472,520">Patents</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717230-bioversys-identifies-optimized-lead-compounds-in-bv500-ntm-program">Bioversys identifies optimized lead compounds in BV500 NTM program</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/263,520">Respiratory</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717190-organogold-compound-disrupts-emleishmania-em-mitochondria-and-delays-lesion-progression-in-vivo">Organogold compound disrupts <em>Leishmania</em> mitochondria and delays lesion progression in vivo</a></h1></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/251-infection" href="/articles/topic/251-infection">More in Infection</a> </section></div></div></section><div class="deals-m-a__wrapper"><section class="deals-m-a "> <h1 class="deals-m-a__title"><a class="deals-m-a__title-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-title" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">Neurology/psychiatric</a></h1><ul class="deals-m-a__items"> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717300-bsense-bio-therapeutics-identifies-new-kcnq2-3-and-trpv1-modulators">Bsense Bio Therapeutics identifies new KCNQ2/3 and TRPV1 modulators</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Bsense Bio Therapeutics Ltd. has disclosed new potassium voltage-gated channel subfamily KQT member 2/3 (KCNQ2/3) activators and transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonists reported to be useful for the treatment of neuropathic pain, pruritus and tinnitus.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders" href="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders"><img class="deals-m-a__image-thumb" alt="Brain as light bulb filament" title="Brain as light bulb filament" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Brain-as-filament-in-light-bulb.jpg?height=355&t=1695308372&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717290-mair-therapeutics-launches-with-focus-on-neurodegenerative-disorders">Mair Therapeutics launches with focus on neurodegenerative disorders</a></h1><div class="deals-m-a__teaser">Mair Therapeutics BV has launched with pre-seed funding from Torrey Pines Investment and Oost NL and with a focus on developing treatments for neurodegenerative disorders, particularly Parkinson’s disease.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717252-brii-biosciences-patents-new-th-agonist-prodrugs-for-multiple-sclerosis">Brii Biosciences patents new TH-β agonist prodrugs for multiple sclerosis</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/472,520">Patents</a></div><div class="deals-m-a__teaser">Brii Biosciences Inc. has identified substituted 2-(3,5-dichloro-4-(4-hydroxy-benzyl)phenoxy)acetamide derivatives that are prodrugs of thyroid hormone receptor β (TH-β) agonists and reported to be useful for the treatment of multiple sclerosis.</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article -has-image deals-m-a--article"><figure class="deals-m-a__image"><a class="deals-m-a__thumbnail-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-image" data-eventlabel="https://www.bioworld.com/articles/717244-fkbp5-inhibition-protects-from-neurodegeneration-in-parkinsons-disease-models" href="https://www.bioworld.com/articles/717244-fkbp5-inhibition-protects-from-neurodegeneration-in-parkinsons-disease-models"><img class="deals-m-a__image-thumb" alt="Brain and neural networks" title="Brain and neural networks" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Neurology/Neurodegenerative-disease.png?height=355&t=1623075193&width=640" /></a></figure><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717244-fkbp5-inhibition-protects-from-neurodegeneration-in-parkinsons-disease-models">FKBP5 inhibition protects from neurodegeneration in Parkinson’s disease models</a></h1><div class="deals-m-a__teaser">Loss of dopaminergic neurons in the substantia nigra and accumulation of α-synuclein (α-Syn) aggregates are the major hallmarks of Parkinson’s disease (PD).</div></div></article> </li> <li class="deals-m-a__item"> <article class="deals-m-a__article deals-m-a--article"><div class="deals-m-a__details deals-m-a__details-1"><h1 class="deals-m-a__headline"><a class="deals-m-a__article-title-link" href="https://www.bioworld.com/articles/717228-microglial-igsf6-knockdown-reduces-ischemic-brain-injury-post-stroke">Microglial IGSF6 knockdown reduces ischemic brain injury post-stroke</a></h1><div class="deals-m-a__topics"><a class="deals-m-a__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="deals-m-a__teaser">Researchers in from Nanjing Drum Tower Hospital have presented data from a study that investigated the role of immunoglobulin superfamily member 6 (IGSF6) microglia during ischemic stroke.</div></div></article> </li> </ul><a class="deals-m-a__more-link" data-eventname="deals-m-a" data-eventcategory="click" data-eventaction="deals-m-a-more-link" data-eventlabel="/articles/topic/256-neurology-psychiatric" href="/articles/topic/256-neurology-psychiatric">More in Neurology/psychiatric</a> </section></div><section class="topics-section-2__wrapper"><div class="topics-section-2__aside"><section class="asia-pacific "> <h1 class="asia-pacific__title"><a class="asia-pacific__title-link" data-eventname="asia-pacific" data-eventcategory="click" data-eventaction="asia-pacific-title" data-eventlabel="/articles/topic/250-immune" href="/articles/topic/250-immune">Immune</a></h1><ul class="asia-pacific__items"> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717305-bispecific-antibody-targeting-kir-and-icos-restores-immune-balance-in-models-of-ibd">Bispecific antibody targeting KIR and ICOS restores immune balance in models of IBD</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717302-adiponectin-blocks-immunotherapy-inflammation-without-impairing-it">Adiponectin blocks immunotherapy inflammation without impairing it</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717299-neumora-therapeutics-reports-nmda-receptor-positive-allosteric-modulators">Neumora Therapeutics reports NMDA receptor positive allosteric modulators</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717286-ensomas-en-374-designated-orphan-drug-for-x-linked-chronic-granulomatous-disease">Ensoma’s EN-374 designated orphan drug for X-linked chronic granulomatous disease</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717243-lycia-therapeutics-advances-protein-degradation-therapies">Lycia Therapeutics advances protein degradation therapies</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717132-cspcs-herpes-zoster-vaccine-gains-clinical-trial-clearance-in-china">CSPC’s herpes zoster vaccine gains clinical trial clearance in China</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717120-rbm47-a-new-target-to-watch-in-thyroid-associated-ophthalmopathy">RBM47, a new target to watch in thyroid-associated ophthalmopathy</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/717035-grifols-collaborates-with-fcr-therapeutics-on-autoimmune-diseases">Grifols collaborates with FcR Therapeutics on autoimmune diseases</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716853-kat6a-inhibition-as-new-therapeutic-strategy-for-ige-mediated-allergic-diseases">KAT6A inhibition as new therapeutic strategy for IgE-mediated allergic diseases</a></h1></article> </li> <li class="asia-pacific__item"> <article class="asia-pacific__article -has-image asia-pacific--article"><h1 class="asia-pacific__headline"><a class="asia-pacific__article-title-link" href="https://www.bioworld.com/articles/716852-lactigas-secretory-iga-replacement-therapy-for-compromised-immune-function-receives-niaid-funding">Lactiga’s secretory IgA replacement therapy for compromised immune function receives NIAID funding</a></h1></article> </li> </ul> </section></div><div class="topics-section-2__row"><div class="topics-section-2__col -one"><section class="bioworld-biome "> <h1 class="bioworld-biome__title"><a class="bioworld-biome__title-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-title" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">Endocrine/metabolic</a></h1><div class="bioworld-biome__items-wrapper"><ul class="bioworld-biome__items bioworld-biome__items-1"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><figure class="bioworld-biome__image"><a class="bioworld-biome__thumbnail-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-image" data-eventlabel="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases"><img class="bioworld-biome__image-thumb" alt="Illustration of siRNA structure" title="Illustration of siRNA structure" width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/BWS/BWS-library/siRNA-structure-model.jpg?height=355&t=1732119622&width=640" /></a></figure><div class="bioworld-biome__details bioworld-biome__details-1"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717287-seed-funding-at-junevity-supports-sirna-therapeutics-for-age-related-diseases">Seed funding at Junevity supports siRNA therapeutics for age-related diseases</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/566,520">Aging</a></div><div class="bioworld-biome__teaser">Junevity Inc. has raised $10 million in seed funding to support its work creating silencing RNA (siRNA) therapeutics to address metabolic and age-related diseases, including type 2 diabetes, obesity and frailty. The seed funding will be used to enhance the company’s RESET platform and develop its...</div></div></article> </li> </ul><ul class="bioworld-biome__items bioworld-biome__items-2"> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717247-scaav9-sumf1-shows-safety-and-efficacy-as-gene-replacement-therapy-for-the-treatment-of-multiple-sulfatase-deficiency">scAAV9/SUMF1 shows safety and efficacy as gene replacement therapy for the treatment of multiple sulfatase deficiency</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/278,520">Gene therapy</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717221-adrenomedullin-pathway-leads-to-insulin-resistance-in-obesity">Adrenomedullin pathway leads to insulin resistance in obesity </a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/240,520">Cardiovascular</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717116-new-prophylactic-immunomodulation-for-upcoming-4d-310-trials-presented">New prophylactic immunomodulation for upcoming 4D-310 trials presented</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/154,520">Conferences</a></div></article> </li> <li class="bioworld-biome__item"> <article class="bioworld-biome__article -has-image bioworld-biome--article"><h1 class="bioworld-biome__headline"><a class="bioworld-biome__article-title-link" href="https://www.bioworld.com/articles/717036-arbors-abo-101-awarded-us-orphan-drug-designation-for-primary-hyperoxaluria-type-1">Arbor’s ABO-101 awarded US orphan drug designation for primary hyperoxaluria type 1</a></h1><div class="bioworld-biome__topics"><a class="bioworld-biome__topic-link" href="/articles/topic/402,520">Regulatory</a></div></article> </li> </ul></div><a class="bioworld-biome__more-link" data-eventname="bioworld-biome" data-eventcategory="click" data-eventaction="bioworld-biome-more-link" data-eventlabel="/articles/topic/246-endocrine-metabolic" href="/articles/topic/246-endocrine-metabolic">More in Endocrine/metabolic</a> </section></div><div class="adplugg-tag" data-adplugg-zone="bioworld_science_promo_2"></div></div><div class="topics-section-2__row"><div class="topics-section-2__col -three"><section class="clinical "> <h1 class="clinical__title"><a class="clinical__title-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-title" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">Biomarkers</a></h1><div class="clinical__items-wrapper"><ul class="clinical__items clinical__items-1"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><figure class="clinical__image"><a class="clinical__thumbnail-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-image" data-eventlabel="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia" href="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia"><img class="clinical__image-thumb" alt="3D illustration showing presence of tumor inside prostate gland " title="3D illustration showing presence of tumor inside prostate gland " width="640" height="355" loading="lazy" src="https://www.bioworld.com/ext/resources/Stock-images/Therapeutic-topics/Cancer/Cancer-prostate-illustration.jpg?height=355&t=1721842077&width=640" /></a></figure><div class="clinical__details clinical__details-1"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717291-rna-panel-detects-and-differentiates-prostate-cancer-from-benign-prostate-hyperplasia">RNA panel detects and differentiates prostate cancer from benign prostate hyperplasia</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="clinical__teaser">Prostate cancer is still one of the main causes of cancer death among men; while prostate-specific antigen (PSA) testing is done for screening, there are recommendations against its use due to its nonspecific and suboptimal results. There is thus an urgent need for new biomarkers that are more...</div></div></article> </li> </ul><ul class="clinical__items clinical__items-2"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/717192-cdca4-as-new-molecular-target-for-bladder-cancer">CDCA4 as new molecular target for bladder cancer</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="clinical__teaser">Previous research has shown that cell division cycle associated 4 (CDCA4) is overexpressed in multiple tumors and is involved in tumor progression. Researchers from Yangtze University and affiliated organizations investigated the role of CDCA4 in bladder cancer.</div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716615-ep400-variants-linked-to-epilepsy-neurodevelopmental-disorders">EP400 variants linked to epilepsy, neurodevelopmental disorders</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/256,520">Neurology/psychiatric</a></div><div class="clinical__teaser">Researchers from Guangzhou Medical University and affiliated organizations presented data from a study that aimed to investigate the disease-causing mechanism of EP400, a gene that encodes the E1A binding protein p400, which is a core catalytic ATPase subunit of ATP-dependent chromatin remodeling...</div></article> </li> </ul><ul class="clinical__items clinical__items-3"> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716568-dap3-gene-behind-perrault-syndrome-study-finds">DAP3 gene behind Perrault syndrome, study finds</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/548,520">Genetic/congenital</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716491-wnt-pcp-signaling-mediators-identified-as-new-markers-in-yellow-nail-syndrome">Wnt/PCP signaling mediators identified as new markers in yellow nail syndrome</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/242,520">Dermatologic</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/716320-new-findings-tie-tlx3-to-autism-spectrum-disorder">New findings tie TLX3 to autism spectrum disorder</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/256,520">Neurology/psychiatric</a></div></article> </li> <li class="clinical__item"> <article class="clinical__article -has-image clinical--article"><h1 class="clinical__headline"><a class="clinical__article-title-link" href="https://www.bioworld.com/articles/715806-rare-btnl8-variants-associated-with-altered-intestinal-permeability-are-enriched-in-mis-c-patients">Rare BTNL8 variants associated with altered intestinal permeability are enriched in MIS-C patients</a></h1><div class="clinical__topics"><a class="clinical__topic-link" href="/articles/topic/250,520">Immune</a></div></article> </li> </ul></div><a class="clinical__more-link" data-eventname="clinical" data-eventcategory="click" data-eventaction="clinical-more-link" data-eventlabel="/articles/topic/543-biomarkers" href="/articles/topic/543-biomarkers">More in Biomarkers</a> </section></div></div></section><section class="topics-section-3__wrapper"><div class="topics-section-3__col"><section class="regulatory "> <h1 class="regulatory__title"><a class="regulatory__title-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-title" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">Gastrointestinal</a></h1><ul class="regulatory__items"> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717303-series-a-financing-at-bambusa-to-advance-bispecific-antibodies-for-immunological-and-inflammatory-disorders">Series A financing at Bambusa to advance bispecific antibodies for immunological and inflammatory disorders</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/292,520">Financings</a></div><div class="regulatory__teaser">Bambusa Therapeutics Inc. has completed an oversubscribed series A financing of approximately $90 million to support its lead programs through phase I trials and advance its pipeline of long-acting bispecific antibodies for immunological and...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717223-hmga1-modulates-wnt-driven-tumorigenesis-in-colorectal-cancer">HMGA1 modulates Wnt-driven tumorigenesis in colorectal cancer</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/239,520">Cancer</a></div><div class="regulatory__teaser">A recent study published in the <em>Journal of Clinical Investigation</em> by researchers at Johns Hopkins University School of Medicine and collaborators identified HMGA1 as a key epigenetic regulator that enhances Wnt signaling in colon cancer.</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717189-pali-2108-colon-activated-prodrug-prevents-ulcerative-colitis-progression">PALI-2108 colon-activated prodrug prevents ulcerative colitis progression</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="regulatory__teaser">Ulcerative colitis is a chronic, immune-mediated disorder of the colon and rectum characterized by mucosal inflammation that damages the bowel wall surface. Current therapeutic options include 5-aminosalicylates, corticosteroids or anti-TNF...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717187-anti-dr3-antibody-demonstrates-efficacy-in-the-treatment-of-ibd">Anti-DR3 antibody demonstrates efficacy in the treatment of IBD</a></h1><div class="regulatory__topics"><a class="regulatory__topic-link" href="/articles/topic/154,520">Conferences</a></div><div class="regulatory__teaser">Death receptor 3 (DR3) is the only signaling receptor for TNF superfamily ligand TL1A, the dysregulation of which has been implicated in multiple inflammatory diseases such as inflammatory bowel disease (IBD). Blockade of TL1A has been shown to...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article -has-image regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/717015-study-hints-at-new-target-for-acute-pancreatitis">Study HINTs at new target for acute pancreatitis</a></h1><div class="regulatory__teaser">Acute pancreatitis (AP) is a gastrointestinal disorder characterized by inflammation and necrosis of the pancreatic acinar cells. Mitochondrial homeostasis is key to energy metabolism and redox homeostasis, both of which are essential for...</div></article> </li> <li class="regulatory__item"> <article class="regulatory__article regulatory--article"><h1 class="regulatory__headline"><a class="regulatory__article-title-link" href="https://www.bioworld.com/articles/716766-mr-2938-regulates-gut-microbiota-composition-and-alleviates-dss-induced-colitis">MR-2938 regulates gut microbiota composition and alleviates DSS-induced colitis</a></h1><div class="regulatory__teaser">Researchers from Ocean University of China and Qingdao Marine Science and Technology Center published data from a preclinical study that investigated the impact of the quinazolinone derivative MR-2938 on gut microbiota during colitis. A dextran...</div></article> </li> </ul><a class="regulatory__more-link" data-eventname="regulatory" data-eventcategory="click" data-eventaction="regulatory-more-link" data-eventlabel="/articles/topic/247-gastrointestinal" href="/articles/topic/247-gastrointestinal">More in Gastrointestinal</a> </section></div><div class="topics-section-3__col"><h2><a class="topics-section__title-link" href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast"><strong>BioWorld Insider Podcast</strong></a></h2> <p> <strong>One-on-one with medical innovators</strong> </p> <table style="width: 100%;"><tbody><tr><td style="width: 100.0000%;"> <p class="regulatory__teaser"> <img src="/ext/resources/images/podcast-section-image.png" style="display: inline-block; vertical-align: bottom; margin: 2px 15px 5px 0px; text-align: left; float: left; max-width: calc(100% - 5px); width: 221px;" alt="podcast microphone, sound waves on purple background" data-uuid="YTAtMTA2MzQz" align="left">Breakthrough medicines, billion-dollar deals, spectacular clinical successes and crushing failures all play a part in biopharma’s dynamic story. Developers make scientific advancements with the potential to change everything, only to face regulatory conundrums and ever-fluctuating markets. BioWorld tracks key events in the fast-moving sector every business day. Now, the BioWorld Insider podcast lets you hear directly from the movers and shakers whose collective work is changing how we all live. Join us each week for a new conversation. </p> </td></tr> <tr><td style="width: 100.0000%;"> <p class="regulatory__teaser"> <br><strong>Recent episodes:</strong> </p> <ul class="regulatory__teaser"> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/53-healing-the-health-divide-for-women" rel=" " target="_self">Healing the health divide for women</a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/52-modifi-gets-creative-on-the-rocky-road-to-a-multibillion-dollar-buyout" rel=" " target="_self">Modifi gets creative on the rocky road to a multibillion-dollar buyout</a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/51-a-quantum-leap-into-the-future-of-drug-development" rel=" noopener noreferrer">A quantum leap into the future of drug development<br></a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/50-gene-and-cell-therapies-will-propel-innovation-says-astellas-cco" rel=" noopener noreferrer" target="_self">Gene and cell therapies will propel innovation, says Astellas CCO<br></a></li> <li><a href="https://www.bioworld.com/media/podcasts/532-bioworld-insider-podcast/play/49-capricor-s-ceo-pursues-a-bla-and-talks-rare-disease" rel=" noopener noreferrer">Capricor’s CEO pursues a BLA and talks rare disease<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/48-the-first-half-of-2024-was-strong-as-m-as-and-financings-dominate" rel=" ">The first half of 2024 was strong as M&As and financings dominate<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/47-the-cost-of-delays-in-development-and-sales-it-s-probably-not-what-you-think" rel=" ">The cost of delays in development and sales: It’s probably not what you think</a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/46-asco-preview-adcs-and-radiotherapies-at-the-forefront-of-this-year-s-conference" rel=" " target="_self">ASCO preview: ADCs and radiotherapies at the forefront of this year’s conference<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/45-fibrobiologics-walks-the-unconventional-financing-path" rel=" " target="_self">Fibrobiologics walks the unconventional financing path<br></a></li> <li><a href="/media/podcasts/532-bioworld-insider-podcast/play/44-back-to-fundamentals-the-latest-numbers-point-to-better-times" rel=" " target="_self">Back to fundamentals: The latest numbers point to better times<br></a></li> </ul> <p class="regulatory__teaser"> <a href="https://www.bioworld.com/media/podcasts/532?audio_file_id=0&id_raw=532&page=1"><u>View all</u></a> </p> </td></tr></tbody></table></div></section><section class="topics-cta__wrapper"><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld</h1><div class="topics-cta__teaser">The news source of record covering the development of innovative human therapies for 25+ years</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld MedTech</h1><div class="topics-cta__teaser">Actionable and timely intelligence on advances in medical devices and technologies for 20+ years</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld Asia</h1><div class="topics-cta__teaser">A weekly monitor of biopharmaceutical news from the industry’s fastest-growing region</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld Science</h1><div class="topics-cta__teaser">Essential discovery and preclinical research news to support crucial drug R&D decisions at the earliest stages</div><a class="topics-cta__link" href="/order">Subscribe</a></div><div class="topics-cta"><h1 class="topics-cta__headline">BioWorld Premium</h1><div class="topics-cta__teaser">Enjoy extended coverage for the most complete market view with BioWorld, BioWorld MedTech, and BioWorld Asia in a single, easy to access subscription</div><a class="topics-cta__link" href="/order">Subscribe</a></div></section></div><footer class="main-footer"><div class="main-footer__top"><nav id="footer-1" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="BioWorld|/topics/84-bioworld" href="/topics/84-bioworld">BioWorld</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Today's news|/topics/84-bioworld" href="/topics/84-bioworld">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Analysis and data insight|/articles/topic/84,109-analysis-and-data-insight-bioworld" href="/articles/topic/84,109-analysis-and-data-insight-bioworld">Analysis and data insight</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Clinical|/articles/topic/84,153-clinical-bioworld" href="/articles/topic/84,153-clinical-bioworld">Clinical</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Data Snapshots|/snapshots" href="/snapshots">Data Snapshots</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Deals and M&A|/articles/topic/84,214-deals-bioworld" href="/articles/topic/84,214-deals-bioworld">Deals and M&A</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Financings|/articles/topic/84,292-financings-bioworld" href="/articles/topic/84,292-financings-bioworld">Financings</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Newco news|/articles/topic/84,391-newco-news-bioworld" href="/articles/topic/84,391-newco-news-bioworld">Newco news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Opinion|/blogs/1-bioworld-perspectives" href="/blogs/1-bioworld-perspectives">Opinion</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Regulatory|/articles/topic/84,402-regulatory-bioworld" href="/articles/topic/84,402-regulatory-bioworld">Regulatory</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-1" data-eventcategory="click" data-eventaction="footer-1-link" data-eventlabel="Science|/articles/topic/84,110-science-bioworld" href="/articles/topic/84,110-science-bioworld">Science</a></li></ul></li></ul></div></nav><nav id="footer-2" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="BioWorld MedTech|/topics/85-bioworld-medtech" href="/topics/85-bioworld-medtech">BioWorld MedTech</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Today's news|/topics/85-bioworld-medtech" href="/topics/85-bioworld-medtech">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Clinical|/articles/topic/85,153-clinical-bioworld-medtech" href="/articles/topic/85,153-clinical-bioworld-medtech">Clinical</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Data Snapshots|/medtech_snapshots" href="/medtech_snapshots">Data Snapshots</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Deals and M&A|/articles/topic/85,214-deals-bioworld-medtech" href="/articles/topic/85,214-deals-bioworld-medtech">Deals and M&A</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Financings|/articles/topic/85,292-financings-bioworld-medtech" href="/articles/topic/85,292-financings-bioworld-medtech">Financings</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Newco news|/articles/topic/85,391-newco-news-bioworld-medtech" href="/articles/topic/85,391-newco-news-bioworld-medtech">Newco news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Opinion|/blogs/2-bioworld-medtech-perspectives" href="/blogs/2-bioworld-medtech-perspectives">Opinion</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Regulatory|/articles/topic/85,402-regulatory-bioworld-medtech" href="/articles/topic/85,402-regulatory-bioworld-medtech">Regulatory</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-2" data-eventcategory="click" data-eventaction="footer-2-link" data-eventlabel="Science|/articles/topic/85,110-science-bioworld-medtech" href="/articles/topic/85,110-science-bioworld-medtech">Science</a></li></ul></li></ul></div></nav><nav id="footer-3" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="BioWorld Asia|/topics/86-bioworld-asia" href="/topics/86-bioworld-asia">BioWorld Asia</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Today's news|/topics/86-bioworld-asia" href="/topics/86-bioworld-asia">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Analysis and data insight|/articles/topic/86,109-analysis-and-data-insight-bioworld-asia" href="/articles/topic/86,109-analysis-and-data-insight-bioworld-asia">Analysis and data insight</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Australia|/articles/topic/86,394-australia-bioworld-asia" href="/articles/topic/86,394-australia-bioworld-asia">Australia</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="China|/articles/topic/86,395-china-bioworld-asia" href="/articles/topic/86,395-china-bioworld-asia">China</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Clinical|/articles/topic/86,153-clinical-bioworld-asia" href="/articles/topic/86,153-clinical-bioworld-asia">Clinical</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Deals and M&A|/articles/topic/86,214-deals-bioworld-asia" href="/articles/topic/86,214-deals-bioworld-asia">Deals and M&A</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Financings|/articles/topic/86,292-financings-bioworld-asia" href="/articles/topic/86,292-financings-bioworld-asia">Financings</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Newco news|/articles/topic/86,391-newco-news-bioworld-asia" href="/articles/topic/86,391-newco-news-bioworld-asia">Newco news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Regulatory|/articles/topic/86,402-regulatory-bioworld-asia" href="/articles/topic/86,402-regulatory-bioworld-asia">Regulatory</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-3" data-eventcategory="click" data-eventaction="footer-3-link" data-eventlabel="Science|/articles/topic/86,110-science-bioworld-asia" href="/articles/topic/86,110-science-bioworld-asia">Science</a></li></ul></li></ul></div></nav><nav id="footer-5" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="BioWorld Science|/topics/520-bioworld-science" href="/topics/520-bioworld-science">BioWorld Science</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Today's news|/topics/520-bioworld-science" href="/topics/520-bioworld-science">Today's news</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Biomarkers|/articles/topic/520,543-biomarkers-bioworld-science" href="/articles/topic/520,543-biomarkers-bioworld-science">Biomarkers</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Cancer|/articles/topic/520,239-cancer-bioworld-science" href="/articles/topic/520,239-cancer-bioworld-science">Cancer</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Conferences|/articles/topic/520,154-conferences-bioworld-science" href="/articles/topic/520,154-conferences-bioworld-science">Conferences</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Endocrine/Metabolic|/articles/topic/520,246-endocrine-metabolic-bioworld-science" href="/articles/topic/520,246-endocrine-metabolic-bioworld-science">Endocrine/Metabolic</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Immune|/articles/topic/520,250-immune-bioworld-science" href="/articles/topic/520,250-immune-bioworld-science">Immune</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Infection|/articles/topic/520,251-infection-bioworld-science" href="/articles/topic/520,251-infection-bioworld-science">Infection</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Neurology/Psychiatric|/articles/topic/520,256-neurology-psychiatric-bioworld-science" href="/articles/topic/520,256-neurology-psychiatric-bioworld-science">Neurology/Psychiatric</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-5" data-eventcategory="click" data-eventaction="footer-5-link" data-eventlabel="Patents|/articles/topic/520,472-patents-bioworld-science" href="/articles/topic/520,472-patents-bioworld-science">Patents</a></li></ul></li></ul></div></nav><nav id="footer-4" class="main-footer__nav"><div class="navigation"><ul class="main-footer__nav-level1__items"><li class="main-footer__nav-level1__item"><a class="main-footer__nav__link -has-children" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="More|javascript:void(0);" href="javascript:void(0);">More</a><ul class="main-footer__nav-level2__items"><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="About|/about" href="/about">About</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Advertise with BioWorld|/advertising" href="/advertising">Advertise with BioWorld</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Archives|/newsletters" href="/newsletters">Archives</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Article reprints and permissions|/reprints" href="/reprints">Article reprints and permissions</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Contact us|https://clarivate.com/cortellis/contact-us/" target="_blank" href="https://clarivate.com/cortellis/contact-us/">Contact us</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Cookie policy|https://clarivate.com/legal/cookie-policy/" target="_blank" href="https://clarivate.com/legal/cookie-policy/">Cookie policy</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Copyright notice|https://clarivate.com/legal/copyright-notice/" target="_blank" href="https://clarivate.com/legal/copyright-notice/">Copyright notice</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Data methodology|/content/methodology-chart" href="/content/methodology-chart">Data methodology</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Infographics: Dynamic digital data analysis|/infographics-index" href="/infographics-index">Infographics: Dynamic digital data analysis</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Podcasts|/media/podcasts/532-bioworld-insider-podcast" href="/media/podcasts/532-bioworld-insider-podcast">Podcasts</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Privacy policy|https://clarivate.com/legal/privacy-policy/" target="_blank" href="https://clarivate.com/legal/privacy-policy/">Privacy policy</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Share your news with BioWorld|/share_your_news" href="/share_your_news">Share your news with BioWorld</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Staff|/staff" href="/staff">Staff</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Terms of use|https://clarivate.com/legal/terms-of-use/" target="_blank" href="https://clarivate.com/legal/terms-of-use/">Terms of use</a></li><li class="main-footer__nav-level2__item"><a class="main-footer__nav__link" data-eventname="footer-4" data-eventcategory="click" data-eventaction="footer-4-link" data-eventlabel="Topic alerts|/rss" href="/rss">Topic alerts</a></li></ul></li></ul></div></nav></div><div class="main-footer__bottom"><a class="social-media-links" title="Follow us" href="/social-media"><div class="social-media-links__callout">Follow Us</div><div class="social-media-links__twitter"></div> <div class="social-media-links__linkedin"></div></a></div><p class="main-footer__copyright">Copyright ©2025. All Rights Reserved. Design, CMS, Hosting & Web Development :: <a href="http://www.epublishing.com" target="_blank">ePublishing</a><br /><button class="ot-sdk-show-settings" id="ot-sdk-btn" style="margin-top: 1rem">Cookie Settings</button></p></footer></div> <script async="async"> //<![CDATA[ require(['bundle/main.bundle']); //]]> </script> </body></html>