CINXE.COM

<!DOCTYPE html> <html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ rdfs: http://www.w3.org/2000/01/rdf-schema# sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema#"> <head> <meta charset="UTF-8"><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:[]},session_replay:{sampling_rate:10.0,mask_text_selector:"",block_selector:"",mask_input_options:{date:true,text_area:true,week:true,select:true,color:true,range:true,textarea:true,url:true,number:true,search:true,month:true,datetime_local:true,tel:true,text:true,time:true,email:true},enabled:true,error_sampling_rate:100.0},session_trace:{sampling_rate:10.0,mode:"PROBABILISTIC",enabled:true,error_sampling_rate:100.0}};(window.NREUM||(NREUM={})).loader_config={xpid:"UA8FUVBADwsIV1VaAgIH",licenseKey:"76fb58fb05",applicationID:"788348530"};;/*! For license information please see nr-loader-full-1.281.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>g,gD:()=>m,xN:()=>p});var n=r(3333),i=r(993);const o=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var a=r(2614),s=r(944),c=r(384),u=r(8122);const d="[data-nr-mask]",l=()=>{const e={feature_flags:[],experimental:{marks:!1,measures:!1,resources:!1},mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},get feature_flags(){return e.feature_flags},set feature_flags(t){e.feature_flags=t},generic_events:{enabled:!0,autoStart:!0},harvest:{interval:30},jserrors:{enabled:!0,autoStart:!0},logging:{enabled:!0,autoStart:!0,level:i.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,autoStart:!0},performance:{get capture_marks(){return e.feature_flags.includes(n.$v.MARKS)||e.experimental.marks},set capture_marks(t){e.experimental.marks=t},get capture_measures(){return e.feature_flags.includes(n.$v.MEASURES)||e.experimental.measures},set capture_measures(t){e.experimental.measures=t},capture_detail:!0,resources:{get enabled(){return e.feature_flags.includes(n.$v.RESOURCES)||e.experimental.resources},set enabled(t){e.experimental.resources=t},asset_types:[],first_party_domains:[],ignore_newrelic:!0}},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:a.wk,inactiveMs:a.BB},session_replay:{autoStart:!0,enabled:!1,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){o(t)?e.mask_selector="".concat(t,",").concat(d):""===t||null===t?e.mask_selector=d:(0,s.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){o(t)?e.block_selector+=",".concat(t):""!==t&&(0,s.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,s.R)(7,t)}},session_trace:{enabled:!0,autoStart:!0},soft_navigations:{enabled:!0,autoStart:!0},spa:{enabled:!0,autoStart:!0},ssl:void 0,user_actions:{enabled:!0,elementAttributes:["id","className","tagName","type"]}}},f={},h="All configuration objects require an agent identifier!";function g(e){if(!e)throw new Error(h);if(!f[e])throw new Error("Configuration for ".concat(e," was never set"));return f[e]}function p(e,t){if(!e)throw new Error(h);f[e]=(0,u.a)(t,l());const r=(0,c.nY)(e);r&&(r.init=f[e])}function m(e,t){if(!e)throw new Error(h);var r=g(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0,harvester:void 0},d={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!d[e])throw new Error("Runtime for ".concat(e," was never set"));return d[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");d[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(d[e],"harvestCount")||Object.defineProperty(d[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=d[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.281.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{OF:()=>u,RI:()=>i,WN:()=>f,bv:()=>o,gm:()=>a,lR:()=>l,m:()=>c,mw:()=>s,sb:()=>d});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s=Boolean("hidden"===a?.document?.visibilityState),c=""+a?.location,u=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),d=u&&"undefined"==typeof SharedWorker,l=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),f=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>u});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};d(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function d(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(d(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)g(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function g(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},d={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:g,addEventListener:g,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=p(e),d=c.length,l=0;l<d;l++)c[l].apply(a,r);var g=v()[s[e]];g&&g.push([f,e,r,a]);return a},get:m,listeners:p,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function g(e,t){n[e]=p(e).concat(t)}function p(e){return n[e]||[]}function m(t){return d[t]=d[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),d=(0,n.Zm)();d.ee||(d.ee=u)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>u});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function u(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>d,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function d(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,u="addEventListener",d="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[u,d],"-",g)}function g(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),c&&h(c.prototype,f),h(a.gm,f)),t.on(u+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(d+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,u);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],d,c),e}finally{i(r+"end",[o,a,l],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{$v:()=>u,TZ:()=>n,Zp:()=>i,kd:()=>c,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3,c=["PageAction","UserAction","BrowserPerformance"],u={MARKS:"experimental.marks",MEASURES:"experimental.measures",RESOURCES:"experimental.resources"}},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>u});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function u(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>d,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>u,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},u={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},d=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>u,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function u(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>u,Rz:()=>d,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState",l=1e3},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>j});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),u=r(5289),d=r(6154),l=r(944),f=r(3969),h=r(384),g=r(6344);const p=["setErrorHandler","finished","addToTrace","addRelease","recordCustomEvent","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",g.G4.RECORD,g.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),R=r(3785),x=r(2646),w=r(3434);const E=new Map;function A(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,w.YM)(i),a=new x.y(s.P);a.level=n.level,a.customAttributes=n.customAttributes;const c=t[r]?.[w.Jt]||t[r];return E.set(c,a),o.inPlace(t,[r],"wrap-logger-",(()=>E.get(c))),i}function T(){const e=(0,h.pV)();p.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const _={};var S=r(9417),O=r(5603),N=r(5284);const I=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let P=!1;function j(e,t={},p,x){let{init:w,info:E,loader_config:j,runtime:C={},exposed:k=!0}=t;C.loaderType=p;const H=(0,h.pV)();E||(w=H.init,E=H.info,j=H.loader_config),(0,S.xN)(e.agentIdentifier,w||{}),(0,O.a)(e.agentIdentifier,j||{}),E.jsAttributes??={},d.bv&&(E.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,E);const L=(0,S.D0)(e.agentIdentifier),D=[E.beacon,E.errorBeacon];P||(L.proxy.assets&&(I(L.proxy.assets),D.push(L.proxy.assets)),L.proxy.beacon&&D.push(L.proxy.beacon),T(),(0,h.US)("activatedFeatures",N.B),e.runSoftNavOverSpa&&=!0===L.soft_navigations.enabled&&L.feature_flags.includes("soft_nav")),C.denyList=[...L.ajax.deny_list||[],...L.ajax.block_internal?D:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const p={};var x=s.ee.get(e),w=x.get("tracer");_[e]=b.g.OFF,x.on(g.G4.REPLAY_RUNNING,(t=>{_[e]=t}));var E="api-",T=E+"ixn-";function S(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(E,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}p.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,x),(0,R.R)(x,e,t,r)},p.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,x),A(x,e,t,{customAttributes:r,level:i})},m.forEach((e=>{p[e]=I(E,e,!0,"api")})),p.addPageAction=I(E,"addPageAction",!0,n.K7.genericEvents),p.recordCustomEvent=I(E,"recordCustomEvent",!0,n.K7.genericEvents),p.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(E,"setPageViewName",!0)()},p.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return S(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},p.setUserId=function(e){if("string"==typeof e||null===e)return S("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},p.setApplicationVersion=function(e){if("string"==typeof e||null===e)return S("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},p.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,x),x.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},p[g.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.RECORD,[],void 0,n.K7.sessionReplay,x)},p[g.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,x),(0,a.p)(g.G4.PAUSE,[],void 0,n.K7.sessionReplay,x)},p.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const N=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,x),h||(0,a.p)(T+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,x),function(){if(w.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw w.emit("fn-err",[arguments,this,t],r),t}finally{w.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,x),i&&(0,a.p)(e+t,[r?(0,v.t)():performance.now(),...arguments],r?null:this,i,x),r?void 0:this}}function P(){r.e(891).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),x.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{N[e]=I(T,e,void 0,h?n.K7.softNav:n.K7.spa)})),p.setCurrentRouteName=h?I(T,"routeName",void 0,n.K7.softNav):I(E,"routeName",!0,n.K7.spa),p.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,x),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!_[e]],void 0,n.K7.jserrors,x)},d.RI?(0,u.GG)((()=>P()),!0):P(),p}(e.agentIdentifier,x,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),P=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>u,K7:()=>s,P3:()=>c,XX:()=>i,qY:()=>n,v4:()=>a});const n="events",i="jserrors",o="browser/blobs",a="rum",s={ajax:"ajax",genericEvents:"generic_events",jserrors:i,logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},c={[s.pageViewEvent]:1,[s.pageViewTiming]:2,[s.metrics]:3,[s.jserrors]:4,[s.spa]:5,[s.ajax]:6,[s.sessionTrace]:7,[s.softNav]:8,[s.sessionReplay]:9,[s.logging]:10,[s.genericEvents]:11},u={[s.pageViewEvent]:a,[s.pageViewTiming]:n,[s.ajax]:n,[s.spa]:n,[s.softNav]:n,[s.metrics]:i,[s.jserrors]:i,[s.sessionTrace]:o,[s.sessionReplay]:o,[s.logging]:"browser/logs",[s.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({95:"nr-full-compressor",222:"nr-full-recorder",891:"nr-full"}[e]+"-1.281.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.281.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={891:"sha512-54Aat8Udm6iAAlMAdj4qB/wPExKn9TKWSsPnD5+K2RMckmHE0cb0CFc0VauDfpPug5wse9qzwDKuwIMa3hX6gw==",222:"sha512-IA751FH/bvhLWl8I5ZELgH0tFQetWKV1G+9qRkPvOrTSv2X2tgItmreKfvrd8zImHp4sIPTnSN0otmgnX7UJXA==",95:"sha512-Rwnn8hCtQVvDGDl0hSpEazVuRDuvlGnJpNuNwuapJ46vDCvUNGBIzCZCrZYygTgVJUjMrfQoMAULb+2gKoTIiQ=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(g);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},g=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={85:0,959:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.281.0.PROD"]=self["webpackChunk:NRBA-1.281.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(){this.agentIdentifier=(0,r.LA)(16)}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}recordCustomEvent(e,t){return this.#e("recordCustomEvent",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var d=i(425);var l=i(1687),f=i(4234),h=i(5289),g=i(6154),p=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(891).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(891).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),t.runtime.harvester.initializedAggregates.push(this.featAggregate),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};g.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,p.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class R extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var x=i(384);var w=i(9908),E=i(2843),A=i(3878),T=i(782),_=i(1863);class S extends b{static featureName=T.T;constructor(e,t=!0){super(e,T.T,t),g.RI&&((0,E.u)((()=>(0,w.p)("docHidden",[(0,_.t)()],void 0,T.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,w.p)("winPagehide",[(0,_.t)()],void 0,T.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class N extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),P=i(3304);class j{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,P.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return L(e)?e:new j(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(L(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function H(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new j(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return L(e.error)?e.error:C(e)}function L(e){return e instanceof Error&&!!e.stack}class D extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",((e,t)=>{this.abortHandler&&(0,w.p)("ierr",[C(e),(0,_.t)(),!0,{},this.#r,t],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),g.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,w.p)("err",[k(e),(0,_.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),g.gm.addEventListener("error",(e=>{this.abortHandler&&(0,w.p)("err",[H(e),(0,_.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var M=i(8990);let K=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===g.gm?0:(0,M.I)(e,U,(function(){return K++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,P.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(void 0===g.gm.XMLHttpRequest)return n;if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=g.gm.XMLHttpRequest,a=g.gm.MutationObserver,s=g.gm.Promise,c=g.gm.setInterval,u="readystatechange",d=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=g.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(u,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,d,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(p?p.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var p=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===u||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",J=["arrayBuffer","blob","json","text","formData"],Q=g.gm.Request,ee=g.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(Q&&ee&&g.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,J.forEach((e=>{r(Q[te],e,X),r(ee[te],e,X)})),r(g.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof g.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,P.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),ue=["load","error","abort","timeout"],de=ue.length,le=(0,x.dV)().o.REQ,fe=(0,x.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,w.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};g.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};ge(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=x,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){E(t,e)}),(0,A.jT)(!1)),g.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},ge(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,_.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<de;s++)r.addEventListener(ue[s],this.listener,(0,A.jT)(!1))}function u(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function d(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,_.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function p(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,_.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,_.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&g.RI&&(t=""+g.gm.location.href):e[0]&&e[0].url?t=e[0].url:g.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,_.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:g.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),ge(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function R(e,t){if(this.endTime=(0,_.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,_.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function x(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<de;t++)e.removeEventListener(ue[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,_.t)()-this.startTime,this.loadCaptureCalled||4!==e.readyState?null==t.status&&(t.status=0):E(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function E(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,w.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",u),t.on("xhr-load-added",d),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",p),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",R)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function ge(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const pe={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!g.RI||pe[t.debugId]++||(pe[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:Re,d3:xe,Kp:we,TZ:Ee,Lc:Ae,uP:Te,Rz:_e}=be;class Se extends b{static featureName=Ee;constructor(e,t=!0){super(e,Ee,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Te,(function(e,t){this.bstStart=(0,_.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,w.p)("bst",[e[0],t,this.bstStart,(0,_.t)()],void 0,a.K7.sessionTrace,r)})),r.on(_e+xe,(function(e){this.time=(0,_.t)(),this.startPath=location.pathname+location.hash})),r.on(_e+we,(function(e){(0,w.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,w.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:Re,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class Ne extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,p.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,w.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,p.Aw)(this.agentIdentifier)}#u=!1;async#c(e){if(!this.#u){this.#u=!0;try{const{Recorder:t}=await Promise.all([i.e(891),i.e(222)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee,agentRef:this.#o}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3333);class Pe extends b{static featureName=Ie.TZ;constructor(e,t=!0){super(e,Ie.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled,e.init.performance.resources.enabled];if(g.RI&&(e.init.user_actions.enabled&&(Ie.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,w.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),Ie.qN.forEach((e=>{const t=(0,v.s)((e=>{(0,w.p)("ua",[e],void 0,this.featureName,this.ee)}),500,{leading:!0});(0,A.sp)(e,t)}))),e.init.performance.resources.enabled&&g.gm.PerformanceObserver?.supportedEntryTypes.includes("resource"))){new PerformanceObserver((e=>{e.getEntries().forEach((e=>{(0,w.p)("browserPerformance.resource",[e],void 0,this.featureName,this.ee)}))})).observe({type:"resource",buffered:!0})}r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var je=i(993),Ce=i(3785);class ke extends b{static featureName=je.TZ;constructor(e,t=!0){super(e,je.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,Ce.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t){super(),g.gm?(this.features={},(0,x.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(R),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,d.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,x.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[R,S,Se,Ne,he,N,D,Pe,ke],loaderType:"pro"})})()})();</script> <link rel="profile" href="http://www.w3.org/1999/xhtml/vocab" /> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <meta name="keywords" content="Diabetes" /> <link rel="canonical" href="https://www.rndsystems.com/research-area/diabetes" /> <meta http-equiv="content-language" content="en-us" /> <link href="https://www.rndsystems.com/research-area/diabetes" rel="alternate" hreflang="x-default" /> <link href="https://www.rndsystems.com/research-area/diabetes" rel="alternate" hreflang="en" /> <link href="https://www.rndsystems.com/cn/research-area/diabetes" rel="alternate" hreflang="zh-cn" /> <meta name="baidu-site-verification" content="NoHNFT2tiZ" /> <meta name="description" content="Learn more about Diabetes including related products, articles and interactive pathways." /> <title>Diabetes Research Areas: R&D Systems</title> <script id="json-ld" type="application/ld+json">[{"@context":"http://schema.org/","@type":"Thing","url":"https://www.rndsystems.com/research-area/diabetes","name":"Diabetes","description":"Kidney Cell Markers\n\n\nDiabetes Mellitus is a metabolic syndrome in which patients do not produce sufficient levels of, or correctly respond to, insulin. Secreted from beta-cells in the islets of Langerhans in the pancreas, insulin is an essential physiological hormone. Under normal physiological conditions, insulin is secreted in response to increased blood glucose levels, stimulates cellular glucose uptake and subsequent storage as glycogen. Type-1 diabetes is characterized by a failure to produce enough insulin. In contrast, insulin is released during type-2 and gestational diabetes, but the body exhibits insulin resistance and fails to respond accordingly. Although the specific cause remains unknown, type-1 diabetes is believed to result following autoimmune destruction of pancreatic beta-cells. Increased risk of developing type-2 diabetes is more commonly associated with lifestyle factors, such as obesity. R&D Systems offers a range of quality products to study biological processes underlying diabetes, including glucose transport, insulin signaling, and inflammation.\n\nTo view our complete solutions for lipid metabolism, glucose homeostasis, and energy balance, please visit our Metabolism page at bio-techne.com."},{"@context":"http://schema.org","@type":"WebPage","breadcrumb":{"@context":"http://schema.org","@type":"BreadcrumbList","itemListElement":[{"@context":"http://schema.org","@type":"ListItem","position":1,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.rndsystems.com/","name":"Home"}},{"@context":"http://schema.org","@type":"ListItem","position":2,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.rndsystems.com/research-area","name":"Research Areas"}},{"@context":"http://schema.org","@type":"ListItem","position":3,"item":{"@context":"http://schema.org","@type":"Thing","@id":"https://www.rndsystems.com/research-area/diabetes","name":"Diabetes"}}]},"potentialaction":{"query":""}}]</script> <meta name="generator" content="Drupal 7 (https://www.drupal.org)" /> <link rel="shortlink" href="https://www.rndsystems.com/research-area/diabetes" /> <meta property="og:site_name" content="www.rndsystems.com" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.rndsystems.com/research-area/diabetes" /> <meta property="og:image" content="https://resources.rndsystems.com/images/Social/2019RnDSystemslogoV.png" /> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.core.min.css?sruw9l"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.theme.min.css?sruw9l"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.menu.min.css?sruw9l"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.autocomplete.min.css?sruw9l"); @import url("https://www.rndsystems.com/modules/system/system.base.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/css/blueimp-gallery.min.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/css/datatables.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_quickorder_responsive/css/et_quickorder_responsive.css?sruw9l"); </style> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/themes/base/minified/jquery.ui.tooltip.min.css?sruw9l"); </style> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/colorbox_node/colorbox_node.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_bestseller_products/css/styles.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_datasheet_page_alert/css/et_datasheet_page_alert.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_internationalization/css/et_internationalization.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_product_page_promo/css/et_product_page_promo.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/css/et_recommendation_engine.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/css/owl.carousel.min.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/css/owl.theme.default.min.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_searchbar_autocomplete/css/et_searchbar_autocomplete.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_top_scroll/css/top_scroll.css?sruw9l"); @import url("https://www.rndsystems.com/modules/field/theme/field.css?sruw9l"); @import url("https://www.rndsystems.com/modules/node/node.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/contrib/views/css/views.css?sruw9l"); </style> <style>.infobox_section{border:thin solid black;padding:10px;margin-bottom:5px;} </style> <style> @import url("https://www.rndsystems.com/sites/all/modules/contrib/userInterface/ckeditor/css/ckeditor.css?sruw9l"); </style> <style> @import url("https://www.rndsystems.com/sites/all/modules/contrib/ctools/css/ctools.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_messages/et_messages_admin.css?sruw9l"); @import url("https://www.rndsystems.com/sites/rndsystems.com/modules/et_researchareasv2/css/et_researchareasv2.css?sruw9l"); @import url("https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_messages/skins/default/et_messages.css?sruw9l"); </style> <link type="text/css" rel="stylesheet" href="https://resources.rndsystems.com/bootstrap/bootstrap.min.css" media="all" /> <style> @import url("https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/css/style.css?sruw9l"); </style>   <script defer="defer" src="https://www.rndsystems.com/sites/rndsystems.com/files/google_tag/language/google_tag.en.script.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/jquery/2.1/jquery.min.js?v=2.1.4"></script> <script>jQuery.migrateMute=true;jQuery.migrateTrace=false;</script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/jquery-migrate/1/jquery-migrate.min.js?v=1"></script> <script src="https://www.rndsystems.com/misc/jquery-extend-3.4.0.js?v=2.1.4"></script> <script src="https://www.rndsystems.com/misc/jquery-html-prefilter-3.5.0-backport.js?v=2.1.4"></script> <script src="https://www.rndsystems.com/misc/jquery.once.js?v=1.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.core.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.widget.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/misc/drupal.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_cookie.js?v=1.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.position.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/misc/ui/jquery.ui.position-1.13.0-backport.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.menu.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.autocomplete.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_searchbar/js/searchbar_autocomplete.js?v=1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jQuery_cycle2.js?v=2.1.6"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery.blueimp-gallery.min.js?v=2.33.0"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/blueimp_et_handler.js?v=2.33.0"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_hoverintent.js?v=1.8.1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_lazyload.js?v=1.9.1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_datatables.js?v=1.9.4"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jquery_tablesorter.js?v=2"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/underscore.js?v=1.6.0"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/external/jquery.cookie.js?v=67fb34f6a866c40d0570"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/jquery.form/4/jquery.form.min.js?v=4.2.1"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_quickorder_responsive/js/et_quickorder_responsive.js?v=1.0.32"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.effect.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.effect-highlight.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/replace/ui/ui/minified/jquery.ui.tooltip.min.js?v=1.10.2"></script> <script src="https://www.rndsystems.com/misc/ajax.js?v=7.98"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/jquery_update/js/jquery_update.js?v=0.0.1"></script> <script src="https://resources.rndsystems.com/bootstrap/bootstrap.min.js"></script> <script defer="defer" src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_onecall/js/et_onecall.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/fields/entityreference/js/entityreference.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_internationalization/js/et_internationalization.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_javafunctions/js/jQuery_et.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/js/et_recommendation_engine.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_recommendation_engine/js/owl.carousel.min.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_top_scroll/js/top_scroll.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/marketo_ma/js/marketo_ma.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/libraries/colorbox/jquery.colorbox-min.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/libraries/DOMPurify/purify.min.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/colorbox/js/colorbox.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/contrib/colorbox/js/colorbox_load.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_cookie_policy/js/et_cookie_policy.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_internationalization/js/rnd_distributors.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_search/json_viewer/js/jsonviewer.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/et_researchareasv2/js/et_researchareasv2.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_searchbar/js/et_searchbar.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/themes/bootstrap/js/misc/_progress.js?v=7.98"></script> <script src="https://www.rndsystems.com/sites/all/modules/et_commerce/et_atc_blocks/js/et_atc_blocks.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/et_commerce/et_atc_blocks/js/et_atc_cart_summary.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_combined_seo/js/et_combined_seo.js?sruw9l"></script> <script>var dataLayer = dataLayer || []; dataLayer.push({"email": ""});</script> <script>var dataLayer = dataLayer || [] dataLayer.push({"event":"userRole","userRole":"anonymous user"});</script> <script src="https://www.rndsystems.com/sites/all/modules/enterprise-tech/et_messages/et_messages.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/rnd.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/et_mobile_theme.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/rnd_menu.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/jquery.livequery.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/jquery.cluetip.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/distributors.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/et_atc_blocks.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/themes/RnD_2017/js/blueimp.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/rndsystems.com/modules/colorbox_node/colorbox_node.js?sruw9l"></script> <script src="https://www.rndsystems.com/sites/all/themes/bootstrap/js/misc/ajax.js?sruw9l"></script> <script>jQuery.extend(Drupal.settings, {"basePath":"\/","pathPrefix":"","setHasJsCookie":0,"ajaxPageState":{"theme":"RnD_2017","theme_token":"PbQtaAKSc9UcaeIYKZ5rz_G0wengCJkxAC8RxxlafpM","jquery_version":"2.1","js":{"0":1,"sites\/all\/themes\/bootstrap\/js\/bootstrap.js":1,"public:\/\/google_tag\/language\/google_tag.en.script.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/jquery\/2.1\/jquery.min.js":1,"1":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/jquery-migrate\/1\/jquery-migrate.min.js":1,"misc\/jquery-extend-3.4.0.js":1,"misc\/jquery-html-prefilter-3.5.0-backport.js":1,"misc\/jquery.once.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.core.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.widget.min.js":1,"misc\/drupal.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_cookie.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.position.min.js":1,"misc\/ui\/jquery.ui.position-1.13.0-backport.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.menu.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.autocomplete.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar\/js\/searchbar_autocomplete.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jQuery_cycle2.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery.blueimp-gallery.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/blueimp_et_handler.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_hoverintent.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_lazyload.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_datatables.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jquery_tablesorter.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/underscore.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/external\/jquery.cookie.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/jquery.form\/4\/jquery.form.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_quickorder_responsive\/js\/et_quickorder_responsive.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.effect.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.effect-highlight.min.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/replace\/ui\/ui\/minified\/jquery.ui.tooltip.min.js":1,"misc\/ajax.js":1,"sites\/rndsystems.com\/modules\/jquery_update\/js\/jquery_update.js":1,"https:\/\/resources.rndsystems.com\/bootstrap\/bootstrap.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_onecall\/js\/et_onecall.js":1,"sites\/all\/modules\/contrib\/fields\/entityreference\/js\/entityreference.js":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/js\/et_internationalization.js":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/js\/jQuery_et.js":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/js\/et_recommendation_engine.js":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/js\/owl.carousel.min.js":1,"sites\/all\/modules\/enterprise-tech\/et_top_scroll\/js\/top_scroll.js":1,"sites\/all\/modules\/contrib\/marketo_ma\/js\/marketo_ma.js":1,"sites\/all\/libraries\/colorbox\/jquery.colorbox-min.js":1,"sites\/all\/libraries\/DOMPurify\/purify.min.js":1,"sites\/all\/modules\/contrib\/colorbox\/js\/colorbox.js":1,"sites\/all\/modules\/contrib\/colorbox\/js\/colorbox_load.js":1,"sites\/all\/modules\/enterprise-tech\/et_cookie_policy\/js\/et_cookie_policy.js":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/js\/rnd_distributors.js":1,"sites\/all\/modules\/enterprise-tech\/et_search\/json_viewer\/js\/jsonviewer.js":1,"sites\/rndsystems.com\/modules\/et_researchareasv2\/js\/et_researchareasv2.js":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar\/js\/et_searchbar.js":1,"sites\/all\/themes\/bootstrap\/js\/misc\/_progress.js":1,"sites\/all\/modules\/et_commerce\/et_atc_blocks\/js\/et_atc_blocks.js":1,"sites\/all\/modules\/et_commerce\/et_atc_blocks\/js\/et_atc_cart_summary.js":1,"sites\/all\/modules\/enterprise-tech\/et_combined_seo\/js\/et_combined_seo.js":1,"2":1,"3":1,"sites\/all\/modules\/enterprise-tech\/et_messages\/et_messages.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/rnd.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/et_mobile_theme.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/rnd_menu.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/jquery.livequery.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/jquery.cluetip.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/distributors.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/et_atc_blocks.js":1,"sites\/rndsystems.com\/themes\/RnD_2017\/js\/blueimp.js":1,"sites\/rndsystems.com\/modules\/colorbox_node\/colorbox_node.js":1,"sites\/all\/themes\/bootstrap\/js\/misc\/ajax.js":1},"css":{"misc\/ui\/jquery.ui.core.css":1,"misc\/ui\/jquery.ui.theme.css":1,"misc\/ui\/jquery.ui.menu.css":1,"misc\/ui\/jquery.ui.autocomplete.css":1,"modules\/system\/system.base.css":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/css\/blueimp-gallery.min.css":1,"sites\/all\/modules\/enterprise-tech\/et_javafunctions\/css\/datatables.css":1,"sites\/all\/modules\/enterprise-tech\/et_quickorder_responsive\/css\/et_quickorder_responsive.css":1,"misc\/ui\/jquery.ui.tooltip.css":1,"sites\/rndsystems.com\/modules\/colorbox_node\/colorbox_node.css":1,"sites\/all\/modules\/enterprise-tech\/et_bestseller_products\/css\/styles.css":1,"sites\/all\/modules\/enterprise-tech\/et_datasheet_page_alert\/css\/et_datasheet_page_alert.css":1,"sites\/all\/modules\/enterprise-tech\/et_internationalization\/css\/et_internationalization.css":1,"sites\/all\/modules\/enterprise-tech\/et_product_page_promo\/css\/et_product_page_promo.css":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/css\/et_recommendation_engine.css":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/css\/owl.carousel.min.css":1,"sites\/all\/modules\/enterprise-tech\/et_recommendation_engine\/css\/owl.theme.default.min.css":1,"sites\/all\/modules\/enterprise-tech\/et_searchbar_autocomplete\/css\/et_searchbar_autocomplete.css":1,"sites\/all\/modules\/enterprise-tech\/et_top_scroll\/css\/top_scroll.css":1,"modules\/field\/theme\/field.css":1,"modules\/node\/node.css":1,"sites\/all\/modules\/contrib\/views\/css\/views.css":1,"0":1,"sites\/all\/modules\/contrib\/userInterface\/ckeditor\/css\/ckeditor.css":1,"sites\/all\/modules\/contrib\/ctools\/css\/ctools.css":1,"sites\/all\/modules\/enterprise-tech\/et_messages\/et_messages_admin.css":1,"sites\/rndsystems.com\/modules\/et_researchareasv2\/css\/et_researchareasv2.css":1,"sites\/all\/modules\/enterprise-tech\/et_messages\/skins\/default\/et_messages.css":1,"https:\/\/resources.rndsystems.com\/bootstrap\/drupal-bootstrap.min.css":1,"https:\/\/resources.rndsystems.com\/bootstrap\/bootstrap.min.css":1,"sites\/rndsystems.com\/themes\/RnD_2017\/css\/style.css":1}},"colorbox":{"transition":"elastic","speed":"350","opacity":"0.85","slideshow":false,"slideshowAuto":true,"slideshowSpeed":"2500","slideshowStart":"start slideshow","slideshowStop":"stop slideshow","current":"{current} of {total}","previous":"\u00ab Prev","next":"Next \u00bb","close":"Close","overlayClose":true,"returnFocus":true,"maxWidth":"98%","maxHeight":"98%","initialWidth":"300","initialHeight":"250","fixed":true,"scrolling":false,"mobiledetect":true,"mobiledevicewidth":"480px","file_public_path":"\/sites\/rndsystems.com\/files","specificPagesDefaultValue":"admin*\nimagebrowser*\nimg_assist*\nimce*\nnode\/add\/*\nnode\/*\/edit\nprint\/*\nprintpdf\/*\nsystem\/ajax\nsystem\/ajax\/*"},"country_name":"United States","et_internationalization":{"social":" \u003Ctable\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.facebook.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_facebook\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.facebook.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003EFind us on Facebook\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.twitter.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_twitter social\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.twitter.com\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022social_text\u0022\u003EFollow us on Twitter\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022https:\/\/www.youtube.com\/user\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_youtube social\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022https:\/\/www.youtube.com\/user\/RnDSystems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022social_text\u0022\u003EWatch us on YouTube\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003Ctr\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.linkedin.com\/company\/r\u0026amp;d-systems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022fp_social_linkedin social\u0022\u003E\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003Ctd\u003E\u003Ca href=\u0022http:\/\/www.linkedin.com\/company\/r\u0026amp;d-systems\u0022 target=\u0022_blank\u0022\u003E\u003Cdiv class=\u0022social_text\u0022\u003EConnect with us on LinkedIn\u003C\/div\u003E\u003C\/a\u003E\u003C\/td\u003E\n \u003C\/tr\u003E\n \u003C\/table\u003E","distphone":"(65) 62720788"},"et_onecall":{"active":"true"},"et_searchbar":{"min_chars":"2"},"etMessages":{"position":"center","vertical":"0","horizontal":"10","fixed":1,"width":"400px","autoclose":0,"opendelay":"0.3","disable_autoclose":0,"show_countdown":1,"hover_autoclose":1,"popin":{"effect":"fadeIn","duration":"slow"},"popout":{"effect":"fadeIn","duration":"slow"}},"et_quickorder_responsive":{"enabled":false,"show_cart":"0","display_price":"0","isDistributor":false},"colorbox_node":{"width":"600px","height":"600px"},"bootstrap":{"anchorsFix":"0","anchorsSmoothScrolling":"0","formHasError":1,"popoverEnabled":1,"popoverOptions":{"animation":1,"html":0,"placement":"right","selector":"","trigger":"click","triggerAutoclose":1,"title":"","content":"","delay":0,"container":"body"},"tooltipEnabled":1,"tooltipOptions":{"animation":1,"html":0,"placement":"auto left","selector":"","trigger":"hover focus","delay":0,"container":"body"}}});</script>                <link rel="apple-touch-icon" sizes="180x180" href="https://resources.rndsystems.com/images/favicons/apple-touch-icon.png"> <link rel="icon" type="image/png" sizes="32x32" href="https://resources.rndsystems.com/images/favicons/favicon32x32.png"> <link rel="icon" type="image/png" sizes="16x16" href="https://resources.rndsystems.com/images/favicons/favicon16x16.png"> <link rel="manifest" href="https://resources.rndsystems.com/images/favicons/site.webmanifest"> <link rel="shortcut icon" href="https://resources.rndsystems.com/images/favicons/favicon.ico"> <meta name="apple-mobile-web-app-title" content="R&D Systems"> <meta name="application-name" content="R&D Systems"> <meta name="msapplication-TileColor" content="#ffffff"> <meta name="msapplication-config" content="https://resources.rndsystems.com/images/favicons/browserconfig.xml"> <meta name="theme-color" content="#ffffff"> </head> <body class="html not-front not-logged-in no-sidebars page-research-area page-research-area-diabetes i18n-en">     <div id="skip-link"> <a href="#main-content" class="element-invisible element-focusable">Skip to main content</a> </div> <div class="region region-page-top"> <noscript aria-hidden="true"><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5JK4G7" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> </div> <header id="header" role="banner">   <div id="bb_container"> <div id="brands_bar"> <div class="region region-brands-bar"> <section id="block-bt-brands-bar-bt-brands-bar" class="block block-bt-brands-bar clearfix"> <li class="bb_biotechne"><a href="https://www.bio-techne.com" rel="noopener noreferrer" target="_blank" aria-label="Bio-Techne"></a></li><li class="bb_rndsystems active"><a href="https://www.rndsystems.com" rel="noopener noreferrer" target="_self" aria-label="R&D Systems"></a></li><li class="bb_novusbio"><a href="https://www.novusbio.com" rel="noopener noreferrer" target="_blank" aria-label="Novus Biologicals"></a></li><li class="bb_tocris"><a href="https://www.tocris.com" rel="noopener noreferrer" target="_blank" aria-label="Tocris Bioscience"></a></li><li class="bb_proteinsimple"><a href="https://www.bio-techne.com/brands/proteinsimple" rel="noopener noreferrer" target="_blank" aria-label="ProteinSimple"></a></li><li class="bb_biospacific"><a href="https://www.biospacific.com" rel="noopener noreferrer" target="_blank" aria-label="BiosPacific"></a></li><li class="bb_cliniqa"><a href="https://www.cliniqa.com" rel="noopener noreferrer" target="_blank" aria-label="Cliniqa"></a></li><li class="bb_acd"><a href="https://acdbio.com/ " rel="noopener noreferrer" target="_blank" aria-label="ACD"></a></li><li class="bb_rndheme"><a href="https://www.rndheme.com" rel="noopener noreferrer" target="_blank" aria-label="R&D Heme"></a></li> </section> </div> </div> </div> <div id="hd_container"> <div id="logo_block"> <section id="block-logo-block-logo" class="block block-logo-block clearfix"> <a href="/" title="RnD Systems" class="active"></a> </section> </div> <div id="search_bar"> <div class="region region-search-bar"> <section id="block-et-searchbar-et-searchbar-bar" class="block block-et-searchbar clearfix"> <form name="et_searchbar" method="GET" action="/search" class="search_form"><div class="et_searchbar"> <input autocomplete="off" name="keywords" type="text" class="et_searchbar_wide et_searchbar_default" value="" placeholder="Search keyword, molecule name, target, catalog number, or product type" data-default="" spellcheck="false"/><input type="submit" value="" class="search_btn fp_mag_glass_wideSearch"></div></form> </section> </div> </div> <div id="cart_menu_mobile" class="atc_cart_summary_icon"></div> <div id="account_menu_mobile"></div> <div id="account_menu"> <div class="region region-account-menu"> <section id="block-et-internationalization-country-dropdown" class="block block-et-internationalization clearfix"> <div id="internationalization_country_select"> <div class="internationalization_drop"></div> </div> </section> <section id="block-et-internationalization-sign-in" class="block block-et-internationalization clearfix"> <div id="sign_in"><a href="/user/login" rel="nofollow"><noscript>Account</noscript></a></div> </section> <section id="block-et-cookie-policy-cookie-policy" class="block block-et-cookie-policy clearfix"> <div></div> </section> <section id="block-et-atc-blocks-et-atc-cart-summary" class="block block-et-atc-blocks clearfix"> <ul class="menu nav"> <li class="first last leaf active"><div class="atc_blocks_items_in_cart" style="display:none;"></div></li> </ul> </section> </div> </div> </div> <div id="mm_container"> <div id="main_menu_mobile"></div> <nav id="main_menu"> <div class="region region-main-menu"> <section id="block-menu-menu-master-menu" class="block block-menu clearfix"> <ul class="menu nav"><li class="first expanded dropdown"><a href="/products" id="menu-master-menu-116406" data-target="#">Products <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu"><li class="first expanded dropdown"><span id="menu-master-menu-116611" data-target="#" class="nolink" tabindex="0">Products by Category <span class="caret"></span></span><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/products/proteins" id="menu-master-menu-121156">Recombinant Proteins</a></li> <li class="leaf"><a href="/products/good-manufacturing-practices-gmp-grade-proteins" id="menu-master-menu-116631">GMP Proteins</a></li> <li class="leaf"><a href="/products/antibodies" id="menu-master-menu-120916">Antibodies</a></li> <li class="leaf"><a href="/products/elisas" id="menu-master-menu-120906">ELISAs</a></li> <li class="leaf"><a href="/products/cometassay" id="menu-master-menu-120986">CometAssay</a></li> <li class="leaf"><a href="/products/luminex-assays-and-high-performance-assays" id="menu-master-menu-121061">Luminex Assays</a></li> <li class="leaf"><a href="/products/luminex-instrumentation" id="menu-master-menu-120461">Luminex Instruments</a></li> <li class="leaf"><a href="/products/cell-culture" id="menu-master-menu-121146">Cell Culture</a></li> <li class="leaf"><a href="/products/stem-cell-products" id="menu-master-menu-122806">Stem Cell Products</a></li> <li class="leaf"><a href="/products/small-molecules-peptides" id="menu-master-menu-116706">Small Molecules & Peptides</a></li> <li class="leaf"><a href="/products/enzymes" id="menu-master-menu-121116">Enzymes</a></li> <li class="leaf"><a href="/products/elispot-kits-fluorospot-kits" id="menu-master-menu-116731">ELISpots</a></li> <li class="leaf"><a href="/products/cdna-clones" id="menu-master-menu-116736">cDNA Clones</a></li> <li class="leaf"><a href="/products/flow-cytometry-workflow-solutions" id="menu-master-menu-120941">Flow Cytometry Workflow Solutions</a></li> <li class="last leaf"><a href="/products/proteome-profiler-antibody-arrays" id="menu-master-menu-116746">Proteome Profiler Antibody Arrays</a></li> </ul></li> <li class="expanded dropdown"><span id="menu-master-menu-116616" data-target="#" class="nolink" tabindex="0">Products by Research Area <span class="caret"></span></span><div class="menu_toggle"></div><ul class="third-level-menu"><li class="first leaf"><a href="/products/cell-therapy" id="menu-master-menu-116751">Cell Therapy</a></li> <li class="leaf"><a href="/products/immunotherapy" id="menu-master-menu-116761">Immunotherapy</a></li> <li class="leaf"><a href="/research-area/cancer" id="menu-master-menu-116771">Cancer</a></li> <li class="leaf"><a href="/research-area/immunology" id="menu-master-menu-116781">Immunology</a></li> <li class="leaf"><a href="/research-area/neuroscience" id="menu-master-menu-116791">Neuroscience</a></li> <li class="leaf"><a href="/products/cell-proliferation-viability-apoptosis" id="menu-master-menu-116821">Apoptosis and Cell Viability</a></li> <li class="leaf"><a href="/products/activity-assays-reagents" id="menu-master-menu-116831">Biological Activity Assays</a></li> <li class="leaf"><a href="/research-area/glycobiology" id="menu-master-menu-116836">Glycobiology</a></li> <li class="leaf"><a href="/research-area/cardiovascular-biology" id="menu-master-menu-116851">Cardiovascular Biology</a></li> <li class="last leaf"><a href="/products/ubiquitin-related-products" id="menu-master-menu-122741">Ubiquitin</a></li> </ul></li> <li class="last leaf menu-background two-column menu_products_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/products05-2017b.jpg" alt="Our Products" /></div><span class="btn nolink" tabindex="0">Our Products</span></li></ul></li> <li class="expanded dropdown"><a href="/services" id="menu-master-menu-116401" data-target="#">Services <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/services" id="menu-master-menu-121056">All Custom Services</a></li> <li class="leaf"><a href="/services/protein-services" id="menu-master-menu-120591">Custom Protein Services</a></li> <li class="leaf"><a href="/services/luminex-assays-custom-development-services" id="menu-master-menu-122756">Luminex Custom Services</a></li> <li class="leaf"><a href="/services/custom-antibody-services" id="menu-master-menu-120551">Custom Antibody Services</a></li> <li class="leaf"><a href="/services/assay-production-custom-development-services" id="menu-master-menu-116866">Assay Custom Services</a></li> <li class="leaf"><a href="/services/custom-services-cell-gene-therapies" id="menu-master-menu-121151">Custom Services for Cell & Gene Therapies</a></li> <li class="leaf"><a href="/services/genome-engineering" id="menu-master-menu-122691">Genome Engineering Services</a></li> <li class="leaf"><a href="/services/bioactivity-testing-services" id="menu-master-menu-116911">Bioactivity Testing Services</a></li> <li class="leaf"><a href="/services/custom-chemistry" id="menu-master-menu-116901">Chemistry Services</a></li> <li class="leaf"><a href="/services/bulk-quote-request" id="menu-master-menu-116916">Bulk/Custom Formulation</a></li> <li class="leaf"><a href="/services/custom-cdna-cloning" id="menu-master-menu-116926">Custom cDNA Cloning</a></li> <li class="leaf menu-background one-column menu_services_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/services12-15.jpg" alt="Expedite Your Research" /></div><h4>Expedite Your Research</h4><a href="/services" class="btn">Expedite Your Research</a></li><li class="last leaf"><a href="/services/gmp-antibody-services" id="menu-master-menu-122711">Good Manufacturing Practice (GMP) Antibody Services</a></li> </ul></li> <li class="expanded dropdown"><a href="/pathways" id="menu-master-menu-116411" data-target="#">Pathways <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/pathways/cancer" id="menu-master-menu-116556">Cancer</a></li> <li class="leaf"><a href="/pathways/cardiovascular-biology" id="menu-master-menu-116561">Cardiovascular Biology</a></li> <li class="leaf"><a href="/pathways/developmental-biology" id="menu-master-menu-116566">Development</a></li> <li class="leaf"><a href="/pathways/glycobiology" id="menu-master-menu-116571">Glycobiology</a></li> <li class="leaf"><a href="/pathways/immunology" id="menu-master-menu-116576">Immunology</a></li> <li class="leaf"><a href="/pathways/neuroscience" id="menu-master-menu-116581">Neuroscience</a></li> <li class="leaf"><a href="/pathways/proteases" id="menu-master-menu-116586">Proteases & Other Enzymes</a></li> <li class="leaf"><a href="/pathways/signal-transduction" id="menu-master-menu-116591">Signal Transduction</a></li> <li class="leaf"><a href="/pathways/stem-cells" id="menu-master-menu-116596">Stem Cell</a></li> <li class="leaf"><a href="/pathways/ubiquitin-related-modifiers-and-pathways" id="menu-master-menu-116601">Ubiquitin, Related Modifiers, & Pathways</a></li> <li class="leaf"><a href="/pathways" id="menu-master-menu-116606">View All Pathways</a></li> <li class="last leaf menu-background one-column menu_pathways_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/pathwaysXX.jpg" alt="Explore Our Interactive Pathways" /></div><h4>Award-Winning Interactive Pathways</h4><a href="/pathways" class="btn">Explore Our Interactive Pathways</a></li></ul></li> <li class="expanded dropdown"><a href="/resources" id="menu-master-menu-116416" data-target="#">Resources <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/research-area" id="menu-master-menu-117016">Research Areas</a></li> <li class="leaf"><a href="/resources/protocols-troubleshooting-guides" id="menu-master-menu-117026">Protocols/Troubleshooting Guides/Videos</a></li> <li class="leaf"><a href="/resources/technical-information" id="menu-master-menu-117036">Technical Information</a></li> <li class="leaf"><a href="/resources/articles" id="menu-master-menu-117046">Articles</a></li> <li class="leaf"><a href="/resources/faqs" id="menu-master-menu-117056">Help & FAQs</a></li> <li class="leaf"><a href="/resources/literature" id="menu-master-menu-117071">Literature</a></li> <li class="leaf"><a href="/literature-request" id="menu-master-menu-117081">Request Literature</a></li> <li class="leaf"><a href="/resources/calculators" id="menu-master-menu-117091">Calculators</a></li> <li class="leaf"><a href="/resources/posters" id="menu-master-menu-117096">Posters</a></li> <li class="leaf"><a href="/blog" id="menu-master-menu-117106">Blog</a></li> <li class="leaf"><a href="/promotions" id="menu-master-menu-117121">Promotions</a></li> <li class="leaf"><a href="/grants-scholarships/bio-techne-travel-grants" id="menu-master-menu-117126">Travel Grants</a></li> <li class="leaf menu-background one-column menu_resources_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/resources-2017.jpg" alt="Request Literature" /></div><h4>Posters, Brochures, Whitepapers & Reference Guides</h4><a href="/literature-request" class="btn">Request Literature</a></li><li class="leaf"><a href="/resources/cell-markers" id="menu-master-menu-120471">Cell Markers</a></li> <li class="last leaf"><a href="https://www.rndsystems.com/products/promotions/get-your-new-lab-and-running" id="menu-master-menu-121241">New Lab Program</a></li> </ul></li> <li class="expanded dropdown"><a href="/quality" id="menu-master-menu-116421" data-target="#">R&D Systems Quality <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="/quality" title="" id="menu-master-menu-116936">Quality Philosophy</a></li> <li class="leaf"><a href="/quality/people" title="" id="menu-master-menu-116946">People</a></li> <li class="leaf"><a href="/quality/place" title="" id="menu-master-menu-116956">Place</a></li> <li class="leaf"><a href="/quality/performance" title="" id="menu-master-menu-116966">Performance</a></li> <li class="leaf"><a href="/quality/product-development" title="" id="menu-master-menu-116976">Product Development</a></li> <li class="leaf"><a href="/quality/customer-satisfaction" title="" id="menu-master-menu-116986">Customer Satisfaction</a></li> <li class="leaf"><a href="/quality/rnd-systems-quality-advantage" title="" id="menu-master-menu-117001">The R&D Systems Quality Advantage</a></li> <li class="leaf"><a href="/quality/documents-certifications-and-faqs" title="" id="menu-master-menu-117006">Documents, Certifications, & FAQs</a></li> <li class="last leaf menu-background one-column menu_quality_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/menu-backgrounds/scientists.jpg" alt="R&D Systems Quality" /></div><h4>Experts in Reagent Quality</h4><span class="btn nolink" tabindex="0">R&D Systems Quality</span></li></ul></li> <li class="expanded dropdown"><a href="/about-us" id="menu-master-menu-116436" data-target="#">About Us <span class="caret"></span></a><div class="menu_toggle"></div><ul class="dropdown-menu short"><li class="first leaf"><a href="https://www.bio-techne.com/about/careers" id="menu-master-menu-116481">Careers</a></li> <li class="leaf"><a href="https://www.bio-techne.com/brands" target="_blank" id="menu-master-menu-116491">Bio-Techne Brands</a></li> <li class="leaf"><a href="https://investors.bio-techne.com/" target="_blank" id="menu-master-menu-116501">Investor Relations</a></li> <li class="last leaf menu-background one-column menu_about_image"><div class="menu_image_mask"><img loading="lazy" src="https://resources.rndsystems.com/images/navigation/aboutUsXX02.jpg" alt="Join Us" /></div><h4>Our People are Our Greatest Asset</h4><a href="/about-us/career-opportunities" class="btn">Join Us</a></li></ul></li> <li class="last leaf"><a href="/support/contact-us" id="menu-master-menu-116471">Contact Us</a></li> </ul> </section> </div> </nav> </div> </header> <div class="breadcrumbs_wrapper"> <div class="breadcrumbs_container"> <div class="breadcrumb"><a href="/">Home</a> <span class="breadcrumb_separator">/</span> <a href="/research-area">Research Areas</a> <span class="breadcrumb_separator">/</span> Diabetes</div> </div> </div> <div class="main-container container"> <section> <a id="main-content"></a> <div class="region region-content"> <section id="block-system-main" class="block block-system clearfix">  <div class="row ra_content"> <div id="ra_menu" class="ra_left col-xs-12 col-sm-4 col-md-3"> <div class="mobile_facet_wrapper"> <div class="search_mobile_buttons"> <div class="ra_toggle btn btn-tertiary">Back to Research Areas </div> </div> <div class="ra_menu_block"> <div class="et-researchareas-research-topics ra_menu_items"> <div class="et-researchareas-topic-block"> <h5 class="et-researchareas-topic-title">Categories Menu</h5> <ul class="et-researchareas-topic-ul" data-count="12" id="menuResearchAreas"> <li class="et-researchareas-topic-li " id="cancer"> <a href="/research-area/cancer"> <span class="icon-cancer"> Cancer </span> </a> </li> <li class="et-researchareas-topic-li " id="cardiovascularbiology"> <a href="/research-area/cardiovascular-biology"> <span class="icon-cardiovascularbiology"> Cardiovascular Biology </span> </a> </li> <li class="et-researchareas-topic-li " id="cytokinesandgrowthfactors"> <a href="/research-area/cytokines-and-growth-factors"> <span class="icon-cytokinesandgrowthfactors"> Cytokines and Growth Factors </span> </a> </li> <li class="et-researchareas-topic-li " id="developmentalbiology"> <a href="/research-area/developmental-biology"> <span class="icon-developmentalbiology"> Developmental Biology </span> </a> </li> <li class="et-researchareas-topic-li " id="endocrinology"> <a href="/research-area/endocrinology"> <span class="icon-endocrinology"> Endocrinology </span> </a> </li> <li class="et-researchareas-topic-li " id="glycobiology"> <a href="/research-area/glycobiology"> <span class="icon-glycobiology"> Glycobiology </span> </a> </li> <li class="et-researchareas-topic-li " id="immunology"> <a href="/research-area/immunology"> <span class="icon-immunology"> Immunology </span> </a> </li> <li class="et-researchareas-topic-li " id="neuroscience"> <a href="/research-area/neuroscience"> <span class="icon-neuroscience"> Neuroscience </span> </a> </li> <li class="et-researchareas-topic-li " id="proteases&otherenzymes"> <a href="/research-area/proteases---other-enzymes"> <span class="icon-proteases&otherenzymes"> Proteases & Other Enzymes </span> </a> </li> <li class="et-researchareas-topic-li " id="signaltransduction"> <a href="/research-area/signal-transduction"> <span class="icon-signaltransduction"> Signal Transduction </span> </a> </li> <li class="et-researchareas-topic-li " id="stemcells"> <a href="/research-area/stem-cells"> <span class="icon-stemcells"> Stem Cells </span> </a> </li> <li class="et-researchareas-topic-li " id="ubiquitinandubiquitinlikemodifiers"> <a href="/research-area/ubiquitin-and-ubiquitin--like-modifiers"> <span class="icon-ubiquitinandubiquitinlikemodifiers"> Ubiquitin and Ubiquitin-like Modifiers </span> </a> </li> </ul> </div> </div> </div> </div> </div> <div class="ra_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="ra_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="ra_header"> <h1 itemprop="name" class="et-researchareas-title">Diabetes</h1> <div itemprop="description" class="et-researchareas-body"> <p><div style="float: right; margin:10px 0 10px 10px; text-align:center"> <a href="/resources/cell-markers/kidney-cells/cells-of-the-kidney/cells-of-the-kidney" title="Kidney Cell Markers"><img src="//resources.rndsystems.com/images/research-areas/kidney-cellmarker-300x300.jpg" width="150" border="0" alt="Kidney Cell Markers"><br />Kidney<br /> Cell Markers</a></div> <P>Diabetes Mellitus is a metabolic syndrome in which patients do not produce sufficient levels of, or correctly respond to, insulin. Secreted from beta-cells in the islets of Langerhans in the pancreas, insulin is an essential physiological hormone. Under normal physiological conditions, insulin is secreted in response to increased blood glucose levels, stimulates cellular glucose uptake and subsequent storage as glycogen. Type-1 diabetes is characterized by a failure to produce enough insulin. In contrast, insulin is released during type-2 and gestational diabetes, but the body exhibits insulin resistance and fails to respond accordingly. Although the specific cause remains unknown, type-1 diabetes is believed to result following autoimmune destruction of pancreatic beta-cells. Increased risk of developing type-2 diabetes is more commonly associated with lifestyle factors, such as obesity. R&D Systems offers a range of quality products to study biological processes underlying diabetes, including glucose transport, insulin signaling, and inflammation.</p> <p>To view our complete solutions for lipid metabolism, glucose homeostasis, and energy balance, please visit our <a href="https://www.bio-techne.com/research/metabolism">Metabolism</a> page at bio-techne.com.</p></p> </div> <div class="et-researchareas-children bullet_tile_parent"> <ul> <li class="et-researchareas-children-li"> <a href="/research-area/igf-family">IGF Family</a></li><li><a href="/research-area/orexin-and-receptors">Orexin and Receptors</a> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">11beta-Hydroxysteroid Dehydrogenase</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/11-beta-hsd-inhibitors">11 beta-HSD Inhibitors</a></li> <li><a href="/target/11-beta-hsd1">11 beta-HSD1</a></li> <li><a href="/target/11-beta-hsd2">11 beta-HSD2</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">17 beta-Hydroxysteroid Dehydrogenase</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/17-beta-hsd1-hsd17b1">17 beta-HSD1/HSD17B1</a></li> <li><a href="/target/17-beta-hsd14-hsd17b14">17 beta-HSD14/HSD17B14</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Adrenergic Receptors in Diabetes</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/beta-2-adrenergic-r-adrb2">beta-2 Adrenergic R/ADRB2</a></li> <li><a href="/target/beta-3-adrenergic-r-adrb3">beta-3 Adrenergic R/ADRB3</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">BDNF and Receptor</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/bdnf">BDNF</a></li> <li><a href="/target/trkb">TrkB</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">CLC</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/clc">CLC</a></li> <li><a href="/target/clc-cntf-r-alpha-chimera">CLC/CNTF R alpha Chimera</a></li> <li><a href="/target/clf-1-clc-complex">CLF-1/CLC Complex</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">CNTF and Receptor</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/clc-cntf-r-alpha-chimera">CLC/CNTF R alpha Chimera</a></li> <li><a href="/target/cntf">CNTF</a></li> <li><a href="/target/cntfr-alpha">CNTFR alpha</a></li> <li><a href="/target/cntfr-cntf-complex">CNTFR/CNTF Complex</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">EN-RAGE/S100A12</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/en-rage-s100a12">EN-RAGE/S100A12</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">FAM3 Family</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/fam3a">FAM3A</a></li> <li><a href="/target/fam3b">FAM3B</a></li> <li><a href="/target/fam3c">FAM3C</a></li> <li><a href="/target/fam3d">FAM3D</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">FGFs in Diabetes</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/fgf-acidic-fgf1">FGF acidic/FGF1</a></li> <li><a href="/target/fgf-19">FGF-19</a></li> <li><a href="/target/fgf-21">FGF-21</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">GHRHR</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/ghrhr">GHRHR</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Glucagon and Receptor</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/glucagon">Glucagon</a></li> <li><a href="/target/glucagon-r-gcgr">Glucagon R/GCGR</a></li> <li><a href="/target/glucagon-receptor-antagonists">Glucagon Receptor Antagonists</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Glucose Transporters and Associated Molecules</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/ano1-tmem16a">ANO1/TMEM16A</a></li> <li><a href="/target/ano7-ngep">ANO7/NGEP</a></li> <li><a href="/target/clathrin-heavy-chain-2-chc22">Clathrin Heavy Chain 2/CHC22</a></li> <li><a href="/target/glut1">Glut1</a></li> <li><a href="/target/glut12">GLUT12</a></li> <li><a href="/target/glut2">Glut2</a></li> <li><a href="/target/glut3">Glut3</a></li> <li><a href="/target/glut4">Glut4</a></li> <li><a href="/target/glut5">Glut5</a></li> <li><a href="/target/sglt1-slc5a1">SGLT1/SLC5A1</a></li> <li><a href="/target/sortilin">Sortilin</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Growth Hormone (GH) and Receptors</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/ghrhr">GHRHR</a></li> <li><a href="/target/ghsr">GHSR</a></li> <li><a href="/target/growth-hormone">Growth Hormone</a></li> <li><a href="/target/growth-hormone-2">Growth Hormone 2</a></li> <li><a href="/target/growth-hormone-r-ghr">Growth Hormone R/GHR</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">IL-6 and Receptors</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/gp130">gp130</a></li> <li><a href="/target/il-6">IL-6</a></li> <li><a href="/target/il-6-il-6r-alpha-complex">IL-6/IL-6R alpha Complex</a></li> <li><a href="/target/il-6r-alpha">IL-6R alpha</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">IL-8/CXCL8</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/il-8-cxcl8">IL-8/CXCL8</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Insulin and Related Molecules</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/c-peptide">C-Peptide</a></li> <li><a href="/target/insl3">INSL3</a></li> <li><a href="/target/insl4">INSL4</a></li> <li><a href="/target/insl6">INSL6</a></li> <li><a href="/target/insulin">Insulin</a></li> <li><a href="/target/insulin-and-insulin-like-receptor-activators">Insulin and Insulin-like Receptor Activators</a></li> <li><a href="/target/insulin-and-insulin-like-receptor-inhibitors">Insulin and Insulin-like Receptor Inhibitors</a></li> <li><a href="/target/proinsulin">Proinsulin</a></li> <li><a href="/target/insulin-r-cd220">Insulin R/CD220</a></li> <li><a href="/target/insulin-r-igf-i-r-heterotetramer">Insulin R/IGF-I R Heterotetramer</a></li> <li><a href="/target/insrr">INSRR</a></li> <li><a href="/target/insulysin-ide">Insulysin/IDE</a></li> <li><a href="/target/irs1">IRS1</a></li> <li><a href="/target/irs2">IRS2</a></li> <li><a href="/target/other-insulin-and-insulin-like-receptor-products">Other Insulin and Insulin-like Receptor Products</a></li> <li><a href="/target/proprotein-convertase-4-pcsk4">Proprotein Convertase 4/PCSK4</a></li> <li><a href="/target/proprotein-convertase-1-pcsk1">Proprotein Convertase 1/PCSK1</a></li> <li><a href="/target/proprotein-convertase-2-pcsk2">Proprotein Convertase 2/PCSK2</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Klotho beta</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/klotho">Klotho</a></li> <li><a href="/target/klotho-beta">Klotho beta</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Leukemia Inhibitory Factor (LIF) and Receptor</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/lif">LIF</a></li> <li><a href="/target/lifr-alpha">LIFR alpha</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Oncostatin M and Receptor</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/oncostatin-m-osm">Oncostatin M/OSM</a></li> <li><a href="/target/osmr-beta">OSMR beta</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Perilipin</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/perilipin">Perilipin</a></li> <li><a href="/target/perilipin-2">Perilipin-2</a></li> <li><a href="/target/perilipin-3">Perilipin-3</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">PKC Isoforms</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/pkc-alpha">PKC alpha</a></li> <li><a href="/target/pkc-beta-1">PKC beta 1</a></li> <li><a href="/target/pkc-beta-2">PKC beta 2</a></li> <li><a href="/target/pkc-gamma">PKC gamma</a></li> <li><a href="/target/pkc-epsilon">PKC epsilon</a></li> <li><a href="/target/pkc-delta">PKC delta</a></li> <li><a href="/target/pkc-iota-lambda">PKC iota/lambda</a></li> <li><a href="/target/pkc-iota-lambda-zeta">PKC iota/lambda/zeta</a></li> <li><a href="/target/pkc-theta">PKC theta</a></li> <li><a href="/target/pkc-zeta">PKC zeta</a></li> <li><a href="/target/pkn1">PKN1</a></li> <li><a href="/target/pkn2">PKN2</a></li> <li><a href="/target/protein-kinase-c-activators">Protein Kinase C Activators</a></li> <li><a href="/target/protein-kinase-c-inhibitors">Protein Kinase C Inhibitors</a></li> <li><a href="/target/sdpr">SDPR</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">PPAR</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/ppar-alpha-nr1c1">PPAR alpha/NR1C1</a></li> <li><a href="/target/ppar-alpha-receptor-agonists">PPAR alpha Receptor Agonists</a></li> <li><a href="/target/ppar-alpha-receptor-antagonists">PPAR alpha Receptor Antagonists</a></li> <li><a href="/target/ppar-gamma-nr1c3">PPAR gamma/NR1C3</a></li> <li><a href="/target/ppar-delta-nr1c2">PPAR delta/NR1C2</a></li> <li><a href="/target/ppar-delta-receptor-agonists">PPAR delta Receptor Agonists</a></li> <li><a href="/target/ppar-delta-receptor-antagonists">PPAR delta Receptor Antagonists</a></li> <li><a href="/target/ppar-gamma-receptor-agonists">PPAR gamma Receptor Agonists</a></li> <li><a href="/target/ppar-gamma-receptor-antagonists">PPAR gamma Receptor Antagonists</a></li> <li><a href="/target/additional-ppar-gamma-receptor-products">Additional PPAR gamma Receptor Products</a></li> <li><a href="/target/non-selective-ppar-receptor-agonists">Non-selective PPAR Receptor Agonists</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">RAGE</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/rage-ager">RAGE/AGER</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Reg Family</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/reg1">Reg1</a></li> <li><a href="/target/reg1a">Reg1A</a></li> <li><a href="/target/reg1b">Reg1B</a></li> <li><a href="/target/reg2">Reg2</a></li> <li><a href="/target/reg3a">Reg3A</a></li> <li><a href="/target/reg3b">Reg3B</a></li> <li><a href="/target/reg3d">Reg3D</a></li> <li><a href="/target/reg3g">Reg3G</a></li> <li><a href="/target/reg4">Reg4</a></li> <li><a href="/target/reg1a-b">Reg1A/B</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">SOCs in Diabetes</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/socs-2">SOCS-2</a></li> <li><a href="/target/socs-3">SOCS-3</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">TNF-alpha</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/tnf-alpha">TNF-alpha</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">TNF-alpha Receptors</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/tnf-ri-tnfrsf1a">TNF RI/TNFRSF1A</a></li> <li><a href="/target/tnf-rii-tnfrsf1b">TNF RII/TNFRSF1B</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Wnt Proteins in Diabetes</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/wnt-5b">Wnt-5b</a></li> <li><a href="/target/wnt-7a">Wnt-7a</a></li> <li><a href="/target/wnt-7a-b">Wnt-7a/b</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Other Molecules in Diabetes</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/alpha-2u-globulin">alpha 2u-Globulin</a></li> <li><a href="/target/adropin">Adropin</a></li> <li><a href="/target/cd38">CD38</a></li> <li><a href="/target/cidea">CIDEA</a></li> <li><a href="/target/cidec">CIDEC</a></li> <li><a href="/target/corticosterone">Corticosterone</a></li> <li><a href="/target/creatinine">Creatinine</a></li> <li><a href="/target/dppiv-cd26">DPPIV/CD26</a></li> <li><a href="/target/enpp-1">ENPP-1</a></li> <li><a href="/target/ffar1-gpr40">FFAR1/GPR40</a></li> <li><a href="/target/ffar4-gpr120">FFAR4/GPR120</a></li> <li><a href="/target/fructosamine-3-kinase-fn3k">Fructosamine-3-kinase/FN3K</a></li> <li><a href="/target/fto">FTO</a></li> <li><a href="/target/gip">GIP</a></li> <li><a href="/target/gipr">GIPR</a></li> <li><a href="/target/glp-1">GLP-1</a></li> <li><a href="/target/glp-1r">GLP-1R</a></li> <li><a href="/target/glucokinase-gck">Glucokinase/GCK</a></li> <li><a href="/target/gpr119">GPR119</a></li> <li><a href="/target/haptoglobin">Haptoglobin</a></li> <li><a href="/target/ia-2-ptprn">IA-2/PTPRN</a></li> <li><a href="/target/ica1">ICA1</a></li> <li><a href="/target/igfals-als">IGFALS/ALS</a></li> <li><a href="/target/irisin-fndc5">Irisin/FNDC5</a></li> <li><a href="/target/lipocalin-10">Lipocalin-10</a></li> <li><a href="/target/lipocalin-13">Lipocalin-13</a></li> <li><a href="/target/lrp-5">LRP-5</a></li> <li><a href="/target/neurod1">NeuroD1</a></li> <li><a href="/target/ngfr-tnfrsf16">NGFR/TNFRSF16</a></li> <li><a href="/target/nkx6-1">NKX6.1</a></li> <li><a href="/target/nts1-ntsr1">NTS1/NTSR1</a></li> <li><a href="/target/nts2-ntsr2">NTS2/NTSR2</a></li> <li><a href="/target/parl">PARL</a></li> <li><a href="/target/pck1">PCK1</a></li> <li><a href="/target/pdx-1-ipf1">PDX-1/IPF1</a></li> <li><a href="/target/pea-15">PEA-15</a></li> <li><a href="/target/pedfr-pnpla2">PEDFR/PNPLA2</a></li> <li><a href="/target/prohibitin">Prohibitin</a></li> <li><a href="/target/pth2r">PTH2R</a></li> <li><a href="/target/rfx6">RFX6</a></li> <li><a href="/target/secretagogin">Secretagogin</a></li> <li><a href="/target/serpin-a12">Serpin A12</a></li> <li><a href="/target/snf1lk2-sik2">SNF1LK2/SIK2</a></li> <li><a href="/target/sorcs1">SorCS1</a></li> <li><a href="/target/sox13">SOX13</a></li> <li><a href="/target/spink1">SPINK1</a></li> <li><a href="/target/srebp2">SREBP2</a></li> <li><a href="/target/st3gal4">ST3GAL4</a></li> <li><a href="/target/stamp2-steap4">STAMP2/STEAP4</a></li> <li><a href="/target/tap1">TAP1</a></li> <li><a href="/target/tap2">TAP2</a></li> <li><a href="/target/tenascin-c">Tenascin C</a></li> <li><a href="/target/timp-3">TIMP-3</a></li> <li><a href="/target/tlr4">TLR4</a></li> <li><a href="/target/wfs1">WFS1</a></li> <li><a href="/target/znt-8">ZnT-8</a></li> </ul> </div> </li> </ul> </div> <div class="ra_menu_block"> <div class="et-researchareas-related-info ra_related_info ra_menu_items"> <div class="et-researchareas-related-info-block"> <h2 class="et-researchareas-related-info-title">Related Information</h2> <ul class="et-researchareas-related-info-ul" data-count="19" id="relatedInformation"> <li class="et-researchareas-related-info-li"> <a href="/resources/articles/adiponectin-type-2-diabetes "> <span class="icon-"> Adiponectin & Type 2 Diabetes </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/research-area/akt-pathway "> <span class="icon-"> Akt Pathway </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/resources/posters/autoimmunity "> <span class="icon-"> Autoimmunity </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/research-area/diabetic-peripheral-neuropathy "> <span class="icon-"> Diabetic Peripheral Neuropathy </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/resources/articles/fgf-21-cloning-clinic "> <span class="icon-"> FGF-21: From Cloning to Clinic </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/products/gfralis-novel-gdf-15-receptor-putative-role-appetite-disorders "> <span class="icon-"> GFRALis A Novel GDF-15 Receptor with a Putative Role in Appetite Disorders </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/research-area/glucose-homeostasis "> <span class="icon-"> Glucose Homeostasis </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/resources/articles/glycated-insulin "> <span class="icon-"> Glycated Insulin </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/research-area/growth-hormone-igf--i-axis "> <span class="icon-"> Growth Hormone/IGF-I Axis </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/pathways/adipokines-insulin-signaling-pathways "> <span class="icon-"> Interactive Pathway: Adipocytokines & Insulin Signaling </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/pathways/angiotensinogen-pathways "> <span class="icon-"> Interactive Pathway: Renin - Angiotensin Pathways </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/resources/articles/klotho-proteins-novel-cofactors-endocrine-fgfs "> <span class="icon-"> Klotho Proteins: Novel Cofactors for Endocrine FGFs </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/research-area/metabolism "> <span class="icon-"> Metabolism </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/products/mouse-obesity-antibody-array "> <span class="icon-"> Mouse Obesity Antibody Array </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/resources/articles/recombinant-proteases-renin-angiotensin-system-ras "> <span class="icon-"> New Tools: Recombinant Proteases of the Renin-Angiotensin System (RAS) </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/research-area/obesity "> <span class="icon-"> Obesity </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/resources/articles/obesity-induced-activation-nlrp3-inflammasome-promotes-insulin-resistance "> <span class="icon-"> Obesity-Induced Activation of the Nlrp3 Inflammasome Promotes Insulin Resistance </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/products/quantikine-elisa-kit-measuring-high-molecular-weight-adiponectin "> <span class="icon-"> Quantikine ELISA Kit for Measuring High Molecular Weight Adiponectin </span> </a> </li> <li class="et-researchareas-related-info-li"> <a href="/product-highlights/recombinant-human-wnt-5b "> <span class="icon-"> Recombinant Human Wnt-5b </span> </a> </li> </ul> </div> </div> </div> </div> </div> </div> </section> <section id="block-block-26" class="block block-block clearfix">  <div class="embeddedServiceInvitation" id="snapins_invite" aria-live="assertive" role="dialog" aria-atomic="true" style="display: none;"> <div class="embeddedServiceInvitationHeader" aria-labelledby="snapins_titletext" aria-describedby="snapins_bodytext" style="height: 48px;"> <img id="embeddedServiceAvatar" /> <span class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> </section> <section id="block-et-messages-et-messages-block" class="block block-et-messages clearfix"> <span></span> </section> </div> </section> </div> <footer id="footer_wrapper" class="container-fluid"> <div id="footer_wrapper_container" class="row"> <div id="footer" class="container"> <div id="footer_container" class="row"> <nav class="footer_column footer_column_1 col-xs-12 col-sm-3"> <div class="region region-footer-column-1"> <section id="block-menu-menu-footer-popular-searches" class="block block-menu clearfix"> <h2 class="block-title">Popular Products</h2> <ul class="menu nav"><li class="first leaf"><a href="/search?category=Proteins%20and%20Enzymes" title="" id="menu-footer-popular-searches-28211">Bioactive Proteins</a></li> <li class="leaf"><a href="/search?category=Luminex%20Assays" title="" id="menu-footer-popular-searches-28216">Luminex Assays</a></li> <li class="leaf"><a href="/search?category=ELISAs" title="" id="menu-footer-popular-searches-28221">ELISA Kits</a></li> <li class="leaf"><a href="/search?category=Small%20Molecules" title="" id="menu-footer-popular-searches-28226">Small Molecules</a></li> <li class="last leaf"><a href="/search?category=Primary%20Antibodies" title="" id="menu-footer-popular-searches-28231">Primary Antibodies</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_2 col-xs-12 col-sm-3"> <div class="region region-footer-column-2"> <section id="block-menu-menu-footer-company-information" class="block block-menu clearfix"> <h2 class="block-title">Company Information</h2> <ul class="menu nav"><li class="first leaf"><a href="/about-us" title="" id="menu-footer-company-information-63901">About Us</a></li> <li class="leaf"><a href="https://www.bio-techne.com/about/careers" id="menu-footer-company-information-63911">Careers</a></li> <li class="leaf"><a href="/quality" title="" id="menu-footer-company-information-63916">R&D Systems Quality</a></li> <li class="last leaf"><a href="https://www.bio-techne.com/brands" id="menu-footer-company-information-24546">Bio-Techne Brands</a></li> </ul> </section> </div> </nav> <nav class="footer_column footer_column_3 col-xs-12 col-sm-3"> <div class="region region-footer-column-3"> <section id="block-menu-menu-footer-support" class="block block-menu clearfix"> <h2 class="block-title">Support</h2> <ul class="menu nav"><li class="first leaf"><a href="/support/contact-us" title="" id="menu-footer-support-32351">Contact Us</a></li> <li class="leaf"><a href="/resources/customer-service-ordering-info" id="menu-footer-support-63931">Ordering R&D Systems Products</a></li> <li class="leaf"><a href="/distributors" title="" id="menu-footer-support-32366">Distributors</a></li> <li class="leaf"><a href="/resources/protocols-troubleshooting-guides" title="" id="menu-footer-support-32371">Protocols</a></li> <li class="last leaf"><a href="/resources/faqs" title="" id="menu-footer-support-24551">FAQs</a></li> </ul> </section> </div> </nav> <div class="footer_column footer_column_4 col-xs-12 col-sm-3"> <div class="region region-footer-column-4"> <section id="block-block-16" class="block block-block clearfix"> <h2 class="block-title">Stay Connected</h2> <p>Get the latest news, product updates, and promotions:</p> <p><a href="/subscribe" rel="nofollow" class="btn btn-primary" title="Subscribe" target="_blank">Subscribe</a></p> <p>Follow R&D Systems:</p> <p> <a class="social_link" href="https://www.facebook.com/RnDSystems" target="_blank" title="R&D Systems on Facebook"><span class="icon-facebook-square"></span></a> <a class="social_link" href="https://x.com/RnDSystems" target="_blank" title="R&D Systems on Twitter"><span class="icon-twitter-square"></span></a> <a class="social_link" href="https://www.youtube.com/user/RnDSystems" target="_blank" title="R&D Systems on YouTube"><span class="icon-youtube-square"></span></a> <a class="social_link" href="https://www.linkedin.com/company/r&d-systems" target="_blank" title="R&D Systems on Linkedin"><span class="icon-linkedin-square"></span></a> </p> </section> </div> </div> </div> </div> </div> </footer> <div id="copyright_wrapper" class="container-fluid"> <div id="copyright_wrapper_container" class="row"> <div id="copyright" class="container"> <div id="copyright_container" class="row"> <div id="copyright_content" class="col-xs-12"> <p> <div class="region region-copyright"> <section id="block-block-21" class="block block-block clearfix"> <div class="copy_left"> <a href="/legal-information" title="Legal Information">Legal</a> | <a href="/legal-information#Terms" title="Terms & Conditions">Terms & Conditions</a> | <a href="/legal-information#privacy" title="Privacy and Cookie Policy">Privacy and Cookie Policy</a> | <a href="/sitemap" title="Sitemap">Sitemap</a> </div> <div class="copy_right">© Copyright 2025 R&D Systems, Inc. All Rights Reserved.</div> </section> </div> </p> </div> </div> </div> </div> </div> <script>var _hmt = _hmt || []; (function() { var hm = document.createElement("script"); hm.async = true; hm.defer = true; hm.src = "//hm.baidu.com/hm.js?9d5a20d7ef7a7e9d0ba4232fd45e5d3f"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })();</script> <script src="https://www.rndsystems.com/sites/all/themes/bootstrap/js/bootstrap.js?sruw9l"></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"76fb58fb05","applicationID":"788348530,30870807","transactionName":"YFdbZBFZXxdWAhAMVlkdeFMXUV4KGAUNFklbU0BvEV1CAVYTBw1PBW1NXxNRUhc=","queueTime":17,"applicationTime":222,"atts":"TBBYEllDTBk=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>