VIB.BE - Why animal research is necessary

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class="region region--content-top"> <div class="region__inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </div> </section> <a id="main-content" class="main-content" tabindex="-1"></a> <main role="main"> <div class="inner"> <section id="content" class="main "> <div class="region region--content"> <div class="region__inner"> <div class="block block--system block--system-main-block" id="block-system-main-block" id=""> <article class="node node--type-page node--view-mode-full"> <div class="node__content"> <div class="layout--layout-onecol tocbotized"> <div class="layout__region layout__region--content"> <div class="block block--entityone-layout-builder block--layout-builder-entity-labelnodepage container container--large block-layout-builder-entity-label page-title--hidden" id=""> <h1 class="page-title visually-hidden">Why animal research is necessary</h1> </div> <div class="small-banner full-width block-header-banner-block text-white overlay-dark image-focus--" id="banner-block-c52"> <div class="text-wrapper"> <div class="header-title"> <h1 class="spoof-h2 field field--name-field-title field--type-string title field__item">Why animal research is necessary</h1> </div> </div> <div class="image-background"> <picture> <source srcset="/sites/vib.sites.vib.be/files/styles/small_header_image/public/2022-06/banner_animalResearch.jpg.webp?itok=a9nAHnPw 1x, /sites/vib.sites.vib.be/files/styles/small_header_image_x2/public/2022-06/banner_animalResearch.jpg.webp?itok=nAjIp9hF 2x" media="(min-width: 1024px)" type="image/webp" width="1340" height="250"/> <source srcset="/sites/vib.sites.vib.be/files/styles/small_header_image_small/public/2022-06/banner_animalResearch.jpg.webp?itok=1OEK8jpB 1x, /sites/vib.sites.vib.be/files/styles/small_header_image/public/2022-06/banner_animalResearch.jpg.webp?itok=a9nAHnPw 2x" media="(min-width: 768px)" type="image/webp" width="670" height="125"/> <img src="/sites/vib.sites.vib.be/files/styles/small_header_image_small/public/2022-06/banner_animalResearch.jpg.webp?itok=1OEK8jpB" width="670" height="125" alt="Animal Research" title="" loading="lazy" /> </picture> </div> </div> <div class="block block--layout-builder block--inline-blockbreadcrumbs" id="breadcrumbs-c53"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"><h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2><ol><li><a href="/en" class="primary-color">Home</a><span class="divider">></span></li><li><a href="/en/research-and-impact" class="primary-color">Research & impact</a><span class="divider">></span></li><li><a href="/en/research-and-impact/responsible-research" class="primary-color">Responsible research</a><span class="divider">></span></li><li><span>Why animal research is necessary</span></li></ol></nav> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--fifty-fifty has-text" id="image-with-text-a95"> <div class="layout"> <div class="layout__item layout__item-image aos-init" data-aos=fade-right> <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-79a362fd3e6" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_medium/public/2023-04/Drupal-mouse_2015_cvib-inedehandschutter_15.jpg.webp?itok=ptB1yx1y 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/Drupal-mouse_2015_cvib-inedehandschutter_15.jpg.webp?itok=-fNe9QfG 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/vib.sites.vib.be/files/2023-04/Drupal-mouse_2015_cvib-inedehandschutter_15.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="Mice" /> </picture> </div> </div> </div> </div> <div class="layout__item layout__item-text aos-init" data-aos=fade-left> <h2 class="field field--name-field-title field--type-string title field__item">Why animal research is still necessary</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>In the quest to understand the causes of complex conditions like dementia and cancer, laboratory animals still play a significant role, including in research at VIB.</p> <p>Cell cultures and other animal-free methods have so far proven inadequate for studying complex processes such as infections, metastasis, pain responses, movement, or memory.</p> <p>That's why our researchers employ model organisms: animal models in which a specific biological process or disease mechanism can be studied, sometimes through specific genetic modifications. This allows them to seek new insights and potential treatment avenues.</p></div> </div> </div> </div> <div class="block--hidden block block--layout-builder block--inline-blocktext-one-col aos-init has-full-width-bg" data-aos=fade-down id="text-one-col-fea"> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="https://vib.be/sites/vib.sites.vib.be/files/2023-09/Our%20view%20on%20animal%20testing.pdf" class="btn btn--dark btn--invert">Read our view on animal testing</a> </div> </div> <div class="block block--layout-builder block--inline-blockimage-columns two-col"data-aos=fade-down id="image-columns-188"> <h2 class="field field--name-field-title field--type-string title field__item">Animal research at VIB</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>A small selection from our research where laboratory animals have played an essential role:</p></div> <div class="field field--name-field-image-column field--type-entity-reference-revisions field--label-hidden layout__items"> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-18f"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-73223608a8a" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/Mouse.jpg.webp?itok=lOOd3WX7 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2023-04/Mouse.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="Mouse" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title secondary-bg field__item">Mice</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Since its establishment, VIB has achieved significant breakthroughs that would not have been possible without animal experiments. In cancer research, VIB scientists discovered specific dendritic cells in mice that are resistant to tumor suppression. By strengthening these cells and reintroducing them as a vaccine, a potent immune response against tumors was triggered in the research animals, slowing tumor growth. Following these successful experiments, clinical trials are now being prepared to develop personalized therapies to address cancer metastasis and relapse. This critical insight in immuno-oncology would not have been possible without animal experiments.</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://originofimpact.sites.vib.be/en/power-patient-how-cancer-vaccines-arm-our-immune-system"> <span>Read more</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-738"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-e0bc1b3c779" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/lama_winter_web.png.webp?itok=7a_lurK- 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2023-04/lama_winter_web.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="Lama winter" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title secondary-bg field__item">Camelids</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>In the '90s, VIB researchers embarked on a promising journey with antibodies from camelids. Thanks to a breakthrough by VUB researchers, VIB was able to pioneer a new antibody technology known as Nanobodies漏. Based on this technology, companies like Ablynx were able to introduce a drug to the market in 2018 for the treatment of aTTP (acquired thrombotic thrombocytopenic purpura), a rare and life-threatening blood disorder. Additionally, the biotech company Argenx continued to build upon the discovery of camel antibodies and launched a drug in 2022 for the neuromuscular disease Myasthenia Gravis. Today, thanks to research on camelids, there are medicines available for these life-threatening illnesses.</p></div> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <span class="read-more read-more-wrapper"> <a href="https://originofimpact.sites.vib.be/en/nanobodies"> <span>Read more</span> <div class="svg-wrapper"> <svg class="icon icon--chevron-right"> <use xlink:href="#icon--chevron-right"></use> </svg> </div> </a> </span> </div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--right media-width--one-fourth has-full-width-bg has-text" id="image-with-text-31e"> <div class="layout"> <div class="layout__item layout__item-image aos-init" data-aos=fade-left> <picture> <source srcset="/sites/vib.sites.vib.be/files/styles/max_width_950/public/2023-04/Mouse%20%281%29.jpg.webp?itok=Zxi9QVRB 1x, /sites/vib.sites.vib.be/files/styles/max_width_950_x2/public/2023-04/Mouse%20%281%29.jpg.webp?itok=IAuKPxiW 2x" media="(min-width: 768px)" type="image/webp" width="800" height="1200"/> <source srcset="/sites/vib.sites.vib.be/files/styles/max_width_700/public/2023-04/Mouse%20%281%29.jpg.webp?itok=NuDSiPaC 1x, /sites/vib.sites.vib.be/files/styles/max_width_700_x2/public/2023-04/Mouse%20%281%29.jpg.webp?itok=FCn8UF7C 2x" media="(min-width: 0px)" type="image/webp" width="700" height="1050"/> <img src="/sites/vib.sites.vib.be/files/styles/max_width_700/public/2023-04/Mouse%20%281%29.jpg.webp?itok=NuDSiPaC" alt="" /> </picture> </div> <div class="layout__item layout__item-text aos-init" data-aos=fade-right> <h2 class="field field--name-field-title field--type-string title field__item">Animal testing?</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>An animal experiment encompasses any use of an animal for scientific or educational purposes in which the animal undergoes at least the same level of pain or distress as in a veterinarian's injection. According to the European animal experimentation regulations, it applies to vertebrate animals (mammals, birds, fish, amphibians, or reptiles), including, in some cases, embryos. The only exceptions are squids and octopuses, which, despite being invertebrates, are still considered experimental animals.</p> <h4 id="whatrulesapply--2">What rules apply?</h4> <ul> <li> <p>The use of animals in research is subject to approval by an ethical committee.</p> </li> <li> <p>Strict requirements are imposed for housing, care, and veterinary supervision.</p> </li> <li> <p>Anyone handling laboratory animals and conducting experiments must have undergone training.</p> </li> <li> <p>It is not allowed to use an animal in an experiment if a valid animal-free alternative exists.</p> </li> </ul></div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockfeature-cards-with-icons" id="feature-cards-with-icons-f09"> <h2 class="field field--name-field-title field--type-string title field__item">The 3 Rs</h2> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>As part of the evaluation of an animal experiment application by the ethical review committees, they check whether the 3Rs are correctly applied.</p></div> <div class="field field--name-field-feature-card-with-image field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item aos-init" data-aos=fade-down> <div class="paragraph paragraph--type--feature-card-with-image paragraph--view-mode--default aos-init"> <div class="card-body"> <h3>Reduce</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>The number of animals used in experiments must be limited to the minimum necessary to obtain a scientific answer to the research question.</p></div> </div> </div> </div> <div class="field__item aos-init" data-aos=fade-down> <div class="paragraph paragraph--type--feature-card-with-image paragraph--view-mode--default aos-init"> <div class="card-body"> <h3>Refine</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>Pain, discomfort, or stress during the animal experiment must be minimized as much as possible. This means, for example, that animals should be anesthetized when feasible.</p></div> </div> </div> </div> <div class="field__item aos-init" data-aos=fade-down> <div class="paragraph paragraph--type--feature-card-with-image paragraph--view-mode--default aos-init"> <div class="card-body"> <h3>Replace</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>An animal experiment is prohibited if a reasonable and practical alternative is available. For instance, if a research question can be answered using cultured cells, then this alternative must be utilized.</p></div> </div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-columns two-col"data-aos=fade-down id="image-columns-b5f"> <h2 class="field field--name-field-title field--type-string title field__item">Examples of the 3 R's at VIB</h2> <div class="field field--name-field-image-column field--type-entity-reference-revisions field--label-hidden layout__items"> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-3f4"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-9e684287c5f" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/opto-fUSI-SingleImage.jpeg.webp?itok=6UlOESRS 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2023-04/opto-fUSI-SingleImage.jpeg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="fUSI" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title secondary-bg field__item">REDUCE: Increasing data per animal experiment</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>VIB researchers are measuring brain activity in mice using functional ultrasound imaging, a method that tracks the dynamics of blood volume in the brain. This technique enables neuroscientists to study global brain processes in mice and significantly increase the amount of data and insights obtained from a single animal experiment.</p></div> </div> </div> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-1c0"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-4911341c795" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/blaasontsteking.png.webp?itok=r2-tX6J9 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2023-04/blaasontsteking.png" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="blaasontsteking" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title secondary-bg field__item">REFINE: Visualizing urinary tract infections</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>VIB researchers have outlined how bioluminescence imaging can be used to sensitively and non-invasively study urinary tract infections in mice. This refined approach will significantly enhance research on urinary tract infections and the discovery of new methods for prevention and treatment.</p></div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-with-text media-position--left media-width--one-third has-text" id="image-with-text-3a1"> <div class="layout"> <div class="layout__item layout__item-image aos-init" data-aos=fade-right> <div class="blazy blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden field__items" data-blazy=""> <div class="field__item"> <div data-b-token="b-d390f00f87e" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 768px)" type="image/webp" width="950" height="633" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_medium/public/2023-04/Pipetting.jpg.webp?itok=dqt1c7hM 1x"/> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/Pipetting.jpg.webp?itok=81JfTns1 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="auto" data-src="/sites/vib.sites.vib.be/files/2023-04/Pipetting.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="cell culture" /> </picture> </div> </div> </div> </div> <div class="layout__item layout__item-text aos-init" data-aos=fade-left> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><h2 id="replaceanimal-freealternatives--2">REPLACE: Animal-free alternatives</h2> <h4 id="rapidinnovation--2">Rapid innovation</h4> <p>In addition to simple 2D cell cultures, there are now 3D cell cultures, organoids, and even organs-on-chips to study biological processes without the use of animals. These methods are continuously improving and offer alternative, often superior, ways to address specific research questions.</p> <h4 id="valuablebutnotalwaysadequate--2">Valuable but not always adequate</h4> <p>Even the most advanced 3D organoids do not fully replicate a living organism. They fall short in mapping biological mechanisms that involve communication and interaction between different tissues and organs or in assessing effects on behavior, coordination, or memory.</p> <h4 id="acomplementaryapproach--2"><strong>A complementary approach</strong></h4> <p>Animal experiments and animal-free alternatives are often used in a complementary manner. For instance, an animal experiment can provide specific information that is subsequently further investigated using animal-free alternatives, and vice versa.</p></div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockimage-columns three-col"data-aos=fade-down id="image-columns-342"> <h2 class="field field--name-field-title field--type-string title field__item">Animal-free innovation at VIB</h2> <div class="field field--name-field-image-column field--type-entity-reference-revisions field--label-hidden layout__items"> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-778"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-9a634890148" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/katarina_stoklund_dittlau_holding_the_microfluidic_chamber.jpg.webp?itok=H4ErObhH 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2023-04/katarina_stoklund_dittlau_holding_the_microfluidic_chamber.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="microfluidic chamber" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title secondary-bg field__item">Microfluidics for ALS research</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>VIB researchers have developed a method for generating human neuromuscular junctions, the contact points between nerves and muscle cells essential for controlling movement by our brains. This model has already been successfully used to study the mechanisms of ALS, an incurable neurodegenerative condition.</p></div> </div> </div> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-a99"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-d390f00f87e" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/Pipetting.jpg.webp?itok=81JfTns1 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2023-04/Pipetting.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="cell culture" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title secondary-bg field__item">Organoids for cancer research</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>VIB researchers have pioneered vascular organoids, allowing them to study endothelial cells (the cells lining our blood vessels) and their responses in tumor tissue. These experiments, traditionally conducted in mice, are now being conducted using this innovative approach.</p></div> </div> </div> <div class="layout__item"> <div class="paragraph paragraph--type--image-column paragraph--view-mode--default" id="image-column-c3f"> <div class="blazy blazy--field blazy--field-image blazy--field-image--default field field--name-field-image field--type-entity-reference field--label-hidden field__item" data-blazy=""> <div data-b-token="b-eb35b409936" class="media media--blazy media--bundle--image media--image media--responsive media--ratio media--ratio--32 is-b-loading"> <picture> <source srcset="about:blank" media="(min-width: 0px)" type="image/webp" width="768" height="512" data-srcset="/sites/vib.sites.vib.be/files/styles/3_2_small/public/2023-04/Fruit%20fly.jpg.webp?itok=WN5W9NS- 1x"/> <img decoding="async" class="media__element b-lazy b-responsive" loading="lazy" data-src="/sites/vib.sites.vib.be/files/2023-04/Fruit%20fly.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="768" height="512" alt="fruit fly vials" /> </picture> </div> </div> <h3 class="field field--name-field-title field--type-string title secondary-bg field__item">Alternative models for CMT</h3> <div class="clearfix text-formatted field field--name-field-text field--type-text-long field--label-hidden field__item"><p>VIB researchers achieved a groundbreaking milestone by developing a fruit fly model for hereditary peripheral neuropathy, specifically for Charcot-Marie-Tooth disease, which affects both motor and sensory nerve cells. Additionally, they created various cellular and yeast models. These models are essential for mapping disease processes and understanding how they result in nerve pathway problems.</p></div> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockaccordeon" id="accordeon-2e7"> <h2 class="field field--name-field-title field--type-string title field__item">FAQ</h2> <div class="field field--name-field-accordeon-item field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default" data-aos=fade-down> <details class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default" open> <summary class="link-color"> <div class="summary-inner"> <span class="summary-text primary-color"> <h5>Can't animal experiments be replaced by computer simulations?</h5> </span> <span class="summary-icon link-color"></span> </div> </summary> <div class="details-wrapper"> <div class="details"> <div class="details-description text-formatted"><p>With the rise of artificial intelligence, it sometimes seems as if computers can provide us with answers to every question. However, every form of artificial intelligence is, of course, fueled by data, and that data must come from somewhere. Therefore, computer models and animal research can be viewed as complementary.</p></div> </div> </div> </details> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default" data-aos=fade-down> <details class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default"> <summary class="link-color"> <div class="summary-inner"> <span class="summary-text primary-color"> <h5>A mouse is not a human. Does an animal experiment have any value for us?</h5> </span> <span class="summary-icon link-color"></span> </div> </summary> <div class="details-wrapper"> <div class="details"> <div class="details-description text-formatted"><p>Animals are not humans, but the use of animals does contribute to generating scientific knowledge that enables the development of new diagnostic and therapeutic approaches for humans. Afterward, clinical studies with humans are still necessary.</p></div> </div> </div> </details> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default" data-aos=fade-down> <details class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default"> <summary class="link-color"> <div class="summary-inner"> <span class="summary-text primary-color"> <h5>Can't we test directly on humans?</h5> </span> <span class="summary-icon link-color"></span> </div> </summary> <div class="details-wrapper"> <div class="details"> <div class="details-description text-formatted"><p>A significant portion of clinical research does involve patients or healthy volunteers. However, for invasive and exploratory research, it's more challenging, though not impossible. For example, VIB researchers collaborate with brain surgeons in university hospitals to recover brain tissue that is surgically removed (e.g., in epilepsy patients) for research purposes.</p> <p>But, there are many practical, ethical, and scientific objections to conducting all research directly in humans. Unlike laboratory animals that live in controlled conditions and are often genetically modified to study the role of a specific protein or gene, this cannot be done with humans.</p></div> </div> </div> </details> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default" data-aos=fade-down> <details class="paragraph paragraph--type--accordeon-item paragraph--view-mode--default"> <summary class="link-color"> <div class="summary-inner"> <span class="summary-text primary-color"> <h5>What breakthroughs do we owe to animal experiments?</h5> </span> <span class="summary-icon link-color"></span> </div> </summary> <div class="details-wrapper"> <div class="details"> <div class="details-description text-formatted"><p>Just look at the list of Nobel Prizes: animal experiments have played a crucial role in numerous medical breakthroughs. From HIV treatments to the development of aromatase inhibitors for breast cancer treatment, from insulin for diabetes treatment to the development of vaccines for polio, Ebola, or COVID-19... We also owe the existence of pacemakers and deep brain stimulation for Parkinson's treatment to animal research.</p></div> </div> </div> </details> </div> </div> </div> </div> <div class="block block--layout-builder block--inline-blockcta has-full-width-bg has-image" id="cta-acf"> <div class="blazy is-b-bg blazy--field blazy--field-image blazy--field-image--full field field--name-field-image field--type-entity-reference field--label-hidden no-overlay field__item" data-blazy=""> <div class="media media--blazy b-lazy b-bg media--bundle--image media--image media--responsive is-b-loading" data-src="/sites/vib.sites.vib.be/files/styles/cta_medium/public/2023-01/banner_public%20outreach_facts%20series_1500%C3%97560px.png.webp?itok=EeIf1TfU" data-b-bg="{"768":{"src":"\/sites\/vib.sites.vib.be\/files\/styles\/cta_medium\/public\/2023-01\/banner_public%20outreach_facts%20series_1500%C3%97560px.png.webp?itok=EeIf1TfU","ratio":43.88000000000000255795384873636066913604736328125},"1440":{"src":"\/sites\/vib.sites.vib.be\/files\/styles\/cta_large\/public\/2023-01\/banner_public%20outreach_facts%20series_1500%C3%97560px.png.webp?itok=varmR74F","ratio":34.719999999999998863131622783839702606201171875}}" data-b-token="b-dd6f94bb1d7"> </div> </div> <div class="cta-banner--text" data-aos=fade-down> <h2 class="field field--name-field-title field--type-string title field__item">Read more in our Laboratory animals Facts Series</h2> <div class="field field--name-field-link field--type-link field--label-hidden btn-wrapper field__item"> <a href="https://vib.be/sites/vib.sites.vib.be/files/2022-05/vib_fact_laboratoryAnimals_EN_2018_1107_LR_0.pdf" class="btn btn--secondary btn--invert">Download the brochure</a> </div> </div> </div> <div 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input.classList.remove("phone-input-error"); }; var initializePhoneInput = function(input, defaultCountry) { return window.intlTelInput(input, { utilsScript: "https://unpkg.com/intl-tel-input@17.0.18/build/js/utils.js", autoHideDialCode: false, separateDialCode: true, initialCountry: defaultCountry, preferredCountries: [] }); } var setPhoneInputEventListeners = function(inputId, input, iti) { input.addEventListener('blur', function() { var errorMessage = document.getElementById("error-msg-" + inputId); if (input.value.trim()) { if (iti.isValidNumber()) { iti.setNumber(iti.getNumber()); if (errorMessage.classList.contains("phone-error")){ hidePhoneInputError(inputId); } } else { showPhoneInputError(inputId) } } else { if (errorMessage.classList.contains("phone-error")){ hidePhoneInputError(inputId); } } }); input.addEventListener("countrychange", function() { iti.setNumber(''); }); input.addEventListener("keydown", function(e) { var charCode = (e.which) ? e.which : e.keyCode; if (charCode > 31 && (charCode < 48 || charCode > 57) && charCode !== 8) { e.preventDefault(); } }); }; var showPhoneInputError = function(inputId) { var errorMessage = document.getElementById("error-msg-" + inputId); var input = document.getElementById(inputId); errorMessage.classList.add("phone-error"); errorMessage.classList.remove("phone-error-hidden"); input.classList.add("phone-input-error"); }; window['recaptcha_callback'] = function() { // Get all recaptchas in the DOM (there may be more than one form on the page). var recaptchas = document.getElementsByClassName("g-recaptcha"); for (var i in recaptchas) { // Set the recaptcha element ID, so the recaptcha can be applied to each element. var recaptcha_id = "recaptcha_" + i; recaptchas[i].id = recaptcha_id; var el = document.getElementById(recaptcha_id); if (el != null) { var sitekey = el.getAttribute("data-sitekey"); var stoken = el.getAttribute("data-stoken"); grecaptcha.render(recaptcha_id, {"sitekey":sitekey,"stoken":stoken}); } } }; _load_script("https://www.google.com/recaptcha/api.js?onload=recaptcha_callback&render=explicit"); var _form_serialize = function(form){if(!form||form.nodeName!=="FORM"){return }var i,j,q=[];for(i=0;i<form.elements.length;i++){if(form.elements[i].name===""){continue}switch(form.elements[i].nodeName){case"INPUT":switch(form.elements[i].type){case"tel":q.push(form.elements[i].name+"="+encodeURIComponent(form.elements[i].previousSibling.querySelector('div.iti__selected-dial-code').innerText)+encodeURIComponent(" 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q.join("&")}; var form_submit = function(e) { e.preventDefault(); if (validate_form()) { // use this trick to get the submit button & disable it using plain javascript document.querySelector('#_form_6_submit').disabled = true; var serialized = _form_serialize(document.getElementById('_form_6_')).replace(/%0A/g, '\\n'); var err = form_to_submit.querySelector('._form_error'); err ? err.parentNode.removeChild(err) : false; _load_script('https://vib.activehosted.com/proc.php?' + serialized + '&jsonp=true'); } return false; }; addEvent(form_to_submit, 'submit', form_submit); })(); </script> </div> </div> </div> </div> </div> </div> </section> <section class="footer"> <div class="region__inner"> <div class="footer__content"> <div class="region region--footer-top"> <div class="region__inner"> <div class="block block--system block--system-breadcrumb-block" id="block-system-breadcrumb-block" id=""> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"><h2 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