Search|Resources to understand how Alnylam鈥檚 RNAi-based medicines work

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By searching, you confirm that your query is unsolicited. </p><p>For more information about our FDA-approved therapies, please see the Full Prescribing Information:</p><ul><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">AMVUTTRA庐 (vutrisiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/GIVLAARI-Prescribing-Information.pdf" target="_blank">GIVLAARI庐 (givosiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/ONPATTRO-Prescribing-Information.pdf" target="_blank">ONPATTRO庐 (patisiran)</a></li><li><a class="no-speedbump" href="https://www.alnylam.com/sites/default/files/pdfs/OXLUMO-Prescribing-Information.pdf" target="_blank">OXLUMO庐 (lumasiran)</a></li></ul></div> </div> </div> </div> <div class="view-content results"> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTRSC02_MI_Obici_EU-ATTR%202023_HELIOS-A%20PROs_MED-ALL-TTRSC02-2300039.pdf" target="_blank"> RNAi Therapy in ATTRv Amyloidosis with Polyneuropathy (HELIOS-A): Patient-reported Experiences and Preferences </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTR02_MI_Polydefkis_AAN_2023_NfL%20Levels_MED-ALL-TTR02-2300126.pdf" target="_blank"> NfL Levels 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Amyloidosis with Polyneuropathy </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" class="pdf-icon"> <div class="custom-media-bookmark-paragraph"> <div class="bookmarks no-auth force-auth"><a id="bookmark-login"><img src="/themes/custom/alnylam/assets/dist/images/bookmark.svg" class="desktop" alt="Bookmark this page"><img src="/themes/custom/alnylam/assets/dist/images/bookmark-mobile.svg" class="mobile" alt="Bookmark this page"></a></div> </div> <div class="custom-media-description-paragraph"> </div> </h2> </div> </div></div> <div class="views-row"><div class="result"> <div class="title"> <h2> <a href="/sites/default/files/2024-03/TTRSC02_MI_Luigetti_PNS_2023_HELIOS-A%20NIS%20Quartiles_MED-ALL-TTRSC02-2300021.pdf" target="_blank"> Impact of Baseline Polyneuropathy Severity on Vutrisiran Treatment Response in the Phase 3 HELIOS-A Study </a> <img src="/themes/custom/alnylam/assets/dist/images/document-icon.svg" alt="This link is a pdf" 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