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mechanistic</title> <meta name="description" content="Search results for: mechanistic"> <meta name="keywords" content="mechanistic"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="mechanistic"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 134</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: mechanistic</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">134</span> Comparing Performance Indicators among Mechanistic, Organic, and Bureaucratic Organizations</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Benchamat%20Laksaniyanon">Benchamat Laksaniyanon</a>, <a href="https://publications.waset.org/abstracts/search?q=Padcharee%20Phasuk"> Padcharee Phasuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Rungtawan%20Boonphanakan"> Rungtawan Boonphanakan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> With globalization, organizations had to adjust to an unstable environment in order to survive in a competitive arena. Typically within the field of management, different types of organizations include mechanistic, bureaucratic and organic ones. In fact, bureaucratic and mechanistic organizations have some characteristics in common. Bureaucracy is one type of Thailand organization which adapted from mechanistic concept to develop an organization that is suitable for the characteristic and culture of Thailand. The objective of this study is to compare the adjustment strategies of both organizations in order to find key performance indicators (KPI) suitable for improving organization in Thailand. The methodology employed is binary logistic regression. The results of this study will be valuable for developing future management strategies for both bureaucratic and mechanistic organizations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mechanistic" title="mechanistic">mechanistic</a>, <a href="https://publications.waset.org/abstracts/search?q=bureaucratic%20and%20organic%20organization" title=" bureaucratic and organic organization"> bureaucratic and organic organization</a>, <a href="https://publications.waset.org/abstracts/search?q=binary%20logistic%20regression" title=" binary logistic regression"> binary logistic regression</a>, <a href="https://publications.waset.org/abstracts/search?q=key%20performance%20indicators%20%28KPI%29" title=" key performance indicators (KPI)"> key performance indicators (KPI)</a> </p> <a href="https://publications.waset.org/abstracts/59516/comparing-performance-indicators-among-mechanistic-organic-and-bureaucratic-organizations" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/59516.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">359</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">133</span> A Review on Water Models of Surface Water Environment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahbaz%20G.%20Hassan">Shahbaz G. Hassan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Water quality models are very important to predict the changes in surface water quality for environmental management. The aim of this paper is to give an overview of the water qualities, and to provide directions for selecting models in specific situation. Water quality models include one kind of model based on a mechanistic approach, while other models simulate water quality without considering a mechanism. Mechanistic models can be widely applied and have capabilities for long-time simulation, with highly complexity. Therefore, more spaces are provided to explain the principle and application experience of mechanistic models. Mechanism models have certain assumptions on rivers, lakes and estuaries, which limits the application range of the model, this paper introduces the principles and applications of water quality model based on the above three scenarios. On the other hand, mechanistic models are more easily to compute, and with no limit to the geographical conditions, but they cannot be used with confidence to simulate long term changes. This paper divides the empirical models into two broad categories according to the difference of mathematical algorithm, models based on artificial intelligence and models based on statistical methods. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=empirical%20models" title="empirical models">empirical models</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematical" title=" mathematical"> mathematical</a>, <a href="https://publications.waset.org/abstracts/search?q=statistical" title=" statistical"> statistical</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20quality" title=" water quality"> water quality</a> </p> <a href="https://publications.waset.org/abstracts/60966/a-review-on-water-models-of-surface-water-environment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60966.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">264</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">132</span> A Method to Determine Cutting Force Coefficients in Turning Using Mechanistic Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=T.%20C.%20Bera">T. C. Bera</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Bansal"> A. Bansal</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Nema"> D. Nema</a> </p> <p class="card-text"><strong>Abstract:</strong></p> During performing turning operation, cutting force plays a significant role in metal cutting process affecting tool-work piece deflection, vibration and eventually part quality. The present research work aims to develop a mechanistic cutting force model and to study the mechanistic constants used in the force model in case of turning operation. The proposed model can be used for the reliable and accurate estimation of the cutting forces establishing relationship of various force components (cutting force and feed force) with uncut chip thickness. The accurate estimation of cutting force is required to improve thin-walled part accuracy by controlling the tool-work piece deflection induced surface errors and tool-work piece vibration. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=turning" title="turning">turning</a>, <a href="https://publications.waset.org/abstracts/search?q=cutting%20forces" title=" cutting forces"> cutting forces</a>, <a href="https://publications.waset.org/abstracts/search?q=cutting%20constants" title=" cutting constants"> cutting constants</a>, <a href="https://publications.waset.org/abstracts/search?q=uncut%20chip%20thickness" title=" uncut chip thickness"> uncut chip thickness</a> </p> <a href="https://publications.waset.org/abstracts/30832/a-method-to-determine-cutting-force-coefficients-in-turning-using-mechanistic-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30832.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">522</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">131</span> CFD Study of Subcooled Boiling Flow at Elevated Pressure Using a Mechanistic Wall Heat Partitioning Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Machimontorn%20Promtong">Machimontorn Promtong</a>, <a href="https://publications.waset.org/abstracts/search?q=Sherman%20C.%20P.%20Cheung"> Sherman C. P. Cheung</a>, <a href="https://publications.waset.org/abstracts/search?q=Guan%20H.%20Yeoh"> Guan H. Yeoh</a>, <a href="https://publications.waset.org/abstracts/search?q=Sara%20Vahaji"> Sara Vahaji</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiyuan%20Tu"> Jiyuan Tu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The wide range of industrial applications involved with boiling flows promotes the necessity of establishing fundamental knowledge in boiling flow phenomena. For this purpose, a number of experimental and numerical researches have been performed to elucidate the underlying physics of this flow. In this paper, the improved wall boiling models, implemented on ANSYS CFX 14.5, were introduced to study subcooled boiling flow at elevated pressure. At the heated wall boundary, the Fractal model, Force balance approach and Mechanistic frequency model are given for predicting the nucleation site density, bubble departure diameter, and bubble departure frequency. The presented wall heat flux partitioning closures were modified to consider the influence of bubble sliding along the wall before the lift-off, which usually happens in the flow boiling. The simulation was performed based on the Two-fluid model, where the standard k-ω SST model was selected for turbulence modelling. Existing experimental data at around 5 bars were chosen to evaluate the accuracy of the presented mechanistic approach. The void fraction and Interfacial Area Concentration (IAC) are in good agreement with the experimental data. However, the predicted bubble velocity and Sauter Mean Diameter (SMD) are over-predicted. This over-prediction may be caused by consideration of only dispersed and spherical bubbles in the simulations. In the future work, the important physical mechanisms of bubbles, such as merging and shrinking during sliding on the heated wall will be incorporated into this mechanistic model to enhance its capability for a wider range of flow prediction. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=subcooled%20boiling%20flow" title="subcooled boiling flow">subcooled boiling flow</a>, <a href="https://publications.waset.org/abstracts/search?q=computational%20fluid%20dynamics%20%28CFD%29" title=" computational fluid dynamics (CFD)"> computational fluid dynamics (CFD)</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanistic%20approach" title=" mechanistic approach"> mechanistic approach</a>, <a href="https://publications.waset.org/abstracts/search?q=two-fluid%20model" title=" two-fluid model"> two-fluid model</a> </p> <a href="https://publications.waset.org/abstracts/67603/cfd-study-of-subcooled-boiling-flow-at-elevated-pressure-using-a-mechanistic-wall-heat-partitioning-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67603.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">318</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">130</span> Modeling Of The Random Impingement Erosion Due To The Impact Of The Solid Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Siamack%20A.%20Shirazi">Siamack A. Shirazi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzin%20Darihaki"> Farzin Darihaki</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Solid particles could be found in many multiphase flows, including transport pipelines and pipe fittings. Such particles interact with the pipe material and cause erosion which threats the integrity of the system. Therefore, predicting the erosion rate is an important factor in the design and the monitor of such systems. Mechanistic models can provide reliable predictions for many conditions while demanding only relatively low computational cost. Mechanistic models utilize a representative particle trajectory to predict the impact characteristics of the majority of the particle impacts that cause maximum erosion rate in the domain. The erosion caused by particle impacts is not only due to the direct impacts but also random impingements. In the present study, an alternative model has been introduced to describe the erosion due to random impingement of particles. The present model provides a realistic trend for erosion with changes in the particle size and particle Stokes number. The present model is examined against the experimental data and CFD simulation results and indicates better agreement with the data incomparison to the available models in the literature. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=erosion" title="erosion">erosion</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanistic%20modeling" title=" mechanistic modeling"> mechanistic modeling</a>, <a href="https://publications.waset.org/abstracts/search?q=particles" title=" particles"> particles</a>, <a href="https://publications.waset.org/abstracts/search?q=multiphase%20flow" title=" multiphase flow"> multiphase flow</a>, <a href="https://publications.waset.org/abstracts/search?q=gas-liquid-solid" title=" gas-liquid-solid"> gas-liquid-solid</a> </p> <a href="https://publications.waset.org/abstracts/144301/modeling-of-the-random-impingement-erosion-due-to-the-impact-of-the-solid-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/144301.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">129</span> Preparing Data for Calibration of Mechanistic-Empirical Pavement Design Guide in Central Saudi Arabia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdulraaof%20H.%20Alqaili">Abdulraaof H. Alqaili</a>, <a href="https://publications.waset.org/abstracts/search?q=Hamad%20A.%20Alsoliman"> Hamad A. Alsoliman </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Through progress in pavement design developments, a pavement design method was developed, which is titled the Mechanistic Empirical Pavement Design Guide (MEPDG). Nowadays, the evolution in roads network and highways is observed in Saudi Arabia as a result of increasing in traffic volume. Therefore, the MEPDG currently is implemented for flexible pavement design by the Saudi Ministry of Transportation. Implementation of MEPDG for local pavement design requires the calibration of distress models under the local conditions (traffic, climate, and materials). This paper aims to prepare data for calibration of MEPDG in Central Saudi Arabia. Thus, the first goal is data collection for the design of flexible pavement from the local conditions of the Riyadh region. Since, the modifying of collected data to input data is needed; the main goal of this paper is the analysis of collected data. The data analysis in this paper includes processing each: Trucks Classification, Traffic Growth Factor, Annual Average Daily Truck Traffic (AADTT), Monthly Adjustment Factors (MAFi), Vehicle Class Distribution (VCD), Truck Hourly Distribution Factors, Axle Load Distribution Factors (ALDF), Number of axle types (single, tandem, and tridem) per truck class, cloud cover percent, and road sections selected for the local calibration. Detailed descriptions of input parameters are explained in this paper, which leads to providing of an approach for successful implementation of MEPDG. Local calibration of MEPDG to the conditions of Riyadh region can be performed based on the findings in this paper. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mechanistic-empirical%20pavement%20design%20guide%20%28MEPDG%29" title="mechanistic-empirical pavement design guide (MEPDG)">mechanistic-empirical pavement design guide (MEPDG)</a>, <a href="https://publications.waset.org/abstracts/search?q=traffic%20characteristics" title=" traffic characteristics"> traffic characteristics</a>, <a href="https://publications.waset.org/abstracts/search?q=materials%20properties" title=" materials properties"> materials properties</a>, <a href="https://publications.waset.org/abstracts/search?q=climate" title=" climate"> climate</a>, <a href="https://publications.waset.org/abstracts/search?q=Riyadh" title=" Riyadh"> Riyadh</a> </p> <a href="https://publications.waset.org/abstracts/63089/preparing-data-for-calibration-of-mechanistic-empirical-pavement-design-guide-in-central-saudi-arabia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63089.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">226</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">128</span> Effect of Climate Change on Road Maintenance in Bangladesh</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20Russedul%20Islam">Mohammed Russedul Islam</a>, <a href="https://publications.waset.org/abstracts/search?q=Shah%20M.%20Muniruzzaman"> Shah M. Muniruzzaman</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Kamrul-Al-Masud"> M. Kamrul-Al-Masud</a>, <a href="https://publications.waset.org/abstracts/search?q=Syed%20Sadat%20Morshed"> Syed Sadat Morshed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bangladesh is one of the most climate vulnerable countries in the world. According to scientists it is predicted that temperature will raise 1-3% and precipitation 20% by 2050 in Bangladesh. Increased temperature and precipitation will deteriorate pavement structure in an accelerated rate. The study has found that pavement life will reduce significantly due to rise in temperature and precipitation in in a coastal road in Bangladesh. It will cause to increase the maintenance cost of the road. The study has found that reduction in pavement life will be caused due the decrease in stiffness and strength parameters of the pavement material due to high temperature and precipitation. It has found that use of new material costlier than the existing one will be necessary to prevent the reduction of pavement life. Eventually it will increase the re-construction cost of the road. The study has used mechanistic-empirical analysis method with a software GAMES (General analysis on multi-layered elastic systems) to find out the effect of temperature and precipitation rise on the pavement life. The study will help to guide road engineers of Bangladesh to prepare in advance to fight with the climate change effect. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=climate%20change" title="climate change">climate change</a>, <a href="https://publications.waset.org/abstracts/search?q=maintenance%20cost" title=" maintenance cost"> maintenance cost</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanistic-empirical%20method" title=" mechanistic-empirical method"> mechanistic-empirical method</a>, <a href="https://publications.waset.org/abstracts/search?q=pavement%20life" title=" pavement life"> pavement life</a> </p> <a href="https://publications.waset.org/abstracts/37676/effect-of-climate-change-on-road-maintenance-in-bangladesh" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37676.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">372</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">127</span> Model-Driven and Data-Driven Approaches for Crop Yield Prediction: Analysis and Comparison</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Xiangtuo%20Chen">Xiangtuo Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Paul-Henry%20Courn%C3%A9de"> Paul-Henry Cournéde</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Crop yield prediction is a paramount issue in agriculture. The main idea of this paper is to find out efficient way to predict the yield of corn based meteorological records. The prediction models used in this paper can be classified into model-driven approaches and data-driven approaches, according to the different modeling methodologies. The model-driven approaches are based on crop mechanistic modeling. They describe crop growth in interaction with their environment as dynamical systems. But the calibration process of the dynamic system comes up with much difficulty, because it turns out to be a multidimensional non-convex optimization problem. An original contribution of this paper is to propose a statistical methodology, Multi-Scenarios Parameters Estimation (MSPE), for the parametrization of potentially complex mechanistic models from a new type of datasets (climatic data, final yield in many situations). It is tested with CORNFLO, a crop model for maize growth. On the other hand, the data-driven approach for yield prediction is free of the complex biophysical process. But it has some strict requirements about the dataset. A second contribution of the paper is the comparison of these model-driven methods with classical data-driven methods. For this purpose, we consider two classes of regression methods, methods derived from linear regression (Ridge and Lasso Regression, Principal Components Regression or Partial Least Squares Regression) and machine learning methods (Random Forest, k-Nearest Neighbor, Artificial Neural Network and SVM regression). The dataset consists of 720 records of corn yield at county scale provided by the United States Department of Agriculture (USDA) and the associated climatic data. A 5-folds cross-validation process and two accuracy metrics: root mean square error of prediction(RMSEP), mean absolute error of prediction(MAEP) were used to evaluate the crop prediction capacity. The results show that among the data-driven approaches, Random Forest is the most robust and generally achieves the best prediction error (MAEP 4.27%). It also outperforms our model-driven approach (MAEP 6.11%). However, the method to calibrate the mechanistic model from dataset easy to access offers several side-perspectives. The mechanistic model can potentially help to underline the stresses suffered by the crop or to identify the biological parameters of interest for breeding purposes. For this reason, an interesting perspective is to combine these two types of approaches. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=crop%20yield%20prediction" title="crop yield prediction">crop yield prediction</a>, <a href="https://publications.waset.org/abstracts/search?q=crop%20model" title=" crop model"> crop model</a>, <a href="https://publications.waset.org/abstracts/search?q=sensitivity%20analysis" title=" sensitivity analysis"> sensitivity analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=paramater%20estimation" title=" paramater estimation"> paramater estimation</a>, <a href="https://publications.waset.org/abstracts/search?q=particle%20swarm%20optimization" title=" particle swarm optimization"> particle swarm optimization</a>, <a href="https://publications.waset.org/abstracts/search?q=random%20forest" title=" random forest"> random forest</a> </p> <a href="https://publications.waset.org/abstracts/72860/model-driven-and-data-driven-approaches-for-crop-yield-prediction-analysis-and-comparison" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72860.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">231</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">126</span> Bioremoval of Malachite Green Dye from Aqueous Solution Using Marine Algae: Isotherm, Kinetic and Mechanistic Study </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Jerold">M. Jerold</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20Sivasubramanian"> V. Sivasubramanian</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study reports the removal of Malachite Green (MG) from simulated wastewater by using marine macro algae Ulva lactuca. Batch biosorption experiments were carried out to determine the biosorption capacity. The biosorption capacity was found to be maximum at pH 10. The effect of various other operation parameters such as biosorbent dosage, initial dye concentration, contact time and agitation was also investigated. The equilibrium attained at 120 min with 0.1 g/L of biosorbent. The isotherm experimental data fitted well with Langmuir Model with R² value of 0.994. The maximum Langmuir biosorption capacity was found to be 76.92 mg/g. Further, Langmuir separation factor RL value was found to be 0.004. Therefore, the adsorption is favorable. The biosorption kinetics of MG was found to follow pseudo second-order kinetic model. The mechanistic study revealed that the biosorption of malachite onto Ulva lactuca was controlled by film diffusion. The solute transfer in a solid-liquid adsorption process is characterized by the film diffusion and/or particle diffusion. Thermodynamic study shows ΔG° is negative indicates the feasibility and spontaneous nature for the biosorption of malachite green. The biosorbent was characterized using Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, and elemental analysis (CHNS: Carbon, Hydrogen, Nitrogen, Sulphur). This study showed that Ulva lactuca can be used as promising biosorbent for the removal of MG from wastewater. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biosorption" title="biosorption">biosorption</a>, <a href="https://publications.waset.org/abstracts/search?q=Ulva%20lactuca" title=" Ulva lactuca"> Ulva lactuca</a>, <a href="https://publications.waset.org/abstracts/search?q=wastewater" title=" wastewater"> wastewater</a>, <a href="https://publications.waset.org/abstracts/search?q=malachite%20green" title=" malachite green"> malachite green</a>, <a href="https://publications.waset.org/abstracts/search?q=isotherm" title=" isotherm"> isotherm</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetics" title=" kinetics "> kinetics </a> </p> <a href="https://publications.waset.org/abstracts/114326/bioremoval-of-malachite-green-dye-from-aqueous-solution-using-marine-algae-isotherm-kinetic-and-mechanistic-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/114326.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">157</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">125</span> Modelling and Simulation Efforts in Scale-Up and Characterization of Semi-Solid Dosage Forms</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saurav%20S.%20Rath">Saurav S. Rath</a>, <a href="https://publications.waset.org/abstracts/search?q=Birendra%20K.%20David"> Birendra K. David</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Generic pharmaceutical industry has to operate in strict timelines of product development and scale-up from lab to plant. Hence, detailed product & process understanding and implementation of appropriate mechanistic modelling and Quality-by-design (QbD) approaches are imperative in the product life cycle. This work provides example cases of such efforts in topical dosage products. Topical products are typically in the form of emulsions, gels, thick suspensions or even simple solutions. The efficacy of such products is determined by characteristics like rheology and morphology. Defining, and scaling up the right manufacturing process with a given set of ingredients, to achieve the right product characteristics presents as a challenge to the process engineer. For example, the non-Newtonian rheology varies not only with CPPs and CMAs but also is an implicit function of globule size (CQA). Hence, this calls for various mechanistic models, to help predict the product behaviour. This paper focusses on such models obtained from computational fluid dynamics (CFD) coupled with population balance modelling (PBM) and constitutive models (like shear, energy density). In a special case of the use of high shear homogenisers (HSHs) for the manufacture of thick emulsions/gels, this work presents some findings on (i) scale-up algorithm for HSH using shear strain, a novel scale-up parameter for estimating mixing parameters, (ii) non-linear relationship between viscosity and shear imparted into the system, (iii) effect of hold time on rheology of product. Specific examples of how this approach enabled scale-up across 1L, 10L, 200L, 500L and 1000L scales will be discussed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=computational%20fluid%20dynamics" title="computational fluid dynamics">computational fluid dynamics</a>, <a href="https://publications.waset.org/abstracts/search?q=morphology" title=" morphology"> morphology</a>, <a href="https://publications.waset.org/abstracts/search?q=quality-by-design" title=" quality-by-design"> quality-by-design</a>, <a href="https://publications.waset.org/abstracts/search?q=rheology" title=" rheology"> rheology</a> </p> <a href="https://publications.waset.org/abstracts/75142/modelling-and-simulation-efforts-in-scale-up-and-characterization-of-semi-solid-dosage-forms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75142.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">269</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">124</span> Understanding Inhibitory Mechanism of the Selective Inhibitors of Cdk5/p25 Complex by Molecular Modeling Studies</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amir%20Zeb">Amir Zeb</a>, <a href="https://publications.waset.org/abstracts/search?q=Shailima%20Rampogu"> Shailima Rampogu</a>, <a href="https://publications.waset.org/abstracts/search?q=Minky%20Son"> Minky Son</a>, <a href="https://publications.waset.org/abstracts/search?q=Ayoung%20Baek"> Ayoung Baek</a>, <a href="https://publications.waset.org/abstracts/search?q=Sang%20H.%20Yoon"> Sang H. Yoon</a>, <a href="https://publications.waset.org/abstracts/search?q=Keun%20W.%20Lee"> Keun W. Lee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Neurotoxic insults activate calpain, which in turn produces truncated p25 from p35. p25 forms hyperactivated Cdk5/p25 complex, and thereby induces severe neuropathological aberrations including hyperphosphorylated tau, neuroinflammation, apoptosis, and neuronal death. Inhibition of Cdk5/p25 complex alleviates aberrant phosphorylation of tau to mitigate AD pathology. PHA-793887 and Roscovitine have been investigated as selective inhibitors of Cdk5/p25 with IC50 values 5nM and 160nM, respectively, but their mechanistic studies remain unknown. Herein, computational simulations have explored the binding mode and interaction mechanism of PHA-793887 and Roscovitine with Cdk5/p25. Docking results suggested that PHA-793887 and Rsocovitine have occupied the ATP-binding site of Cdk5 and obtained highest docking (GOLD) score of 66.54 and 84.03, respectively. Furthermore, molecular dynamics (MD) simulation demonstrated that PHA-793887 and Roscovitine established stable RMSD of 1.09 Å and 1.48 Å with Cdk5/p25, respectively. Profiling of polar interactions suggested that each inhibitor formed hydrogen bonds (H-bond) with catalytic residues of Cdk5 and could remain stable throughout the molecular dynamics simulation. Additionally, binding free energy calculation by molecular mechanics/Poisson–Boltzmann surface area (MM/PBSA) suggested that PHA-793887 and Roscovitine had lowest binding free energies of -150.05 kJ/mol and -113.14 kJ/mol, respectively with Cdk5/p25. Free energy decomposition demonstrated that polar energy by H-bond between the Glu81 of Cdk5 and PHA-793887 is the essential factor to make PHA-793887 highly selective towards Cdk5/p25. Overall, this study provided substantial evidences to explore mechanistic interactions of the selective inhibitors of Cdk5/p25 and could be used as fundamental considerations in the development of structure-based selective inhibitors of Cdk5/p25. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cdk5%2Fp25%20inhibition" title="Cdk5/p25 inhibition">Cdk5/p25 inhibition</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20modeling%20of%20Cdk5%2Fp25" title=" molecular modeling of Cdk5/p25"> molecular modeling of Cdk5/p25</a>, <a href="https://publications.waset.org/abstracts/search?q=PHA-793887%20and%20roscovitine" title=" PHA-793887 and roscovitine"> PHA-793887 and roscovitine</a>, <a href="https://publications.waset.org/abstracts/search?q=selective%20inhibition%20of%20Cdk5%2Fp25" title=" selective inhibition of Cdk5/p25"> selective inhibition of Cdk5/p25</a> </p> <a href="https://publications.waset.org/abstracts/104750/understanding-inhibitory-mechanism-of-the-selective-inhibitors-of-cdk5p25-complex-by-molecular-modeling-studies" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/104750.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">139</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">123</span> Investigation of the Factors Influencing the Construction Planning Process Using Participant Observation Method</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ashokkumar%20Subbiah">Ashokkumar Subbiah</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study investigates the impact of factors that influenced the success of construction planning for a major construction project in Qatar. An approach of participant observation is adopted which is informed by the principles of ethnography: one that reports the participants’ view of their world rather than imposing an artificial theoretical framework upon it. As participant observant, key factors were observed and identified that had an impact on the management and execution of the construction planning. It is found that a ‘shadow culture’ exists between the project participants which, it is argued, is only observable from the perspective of an embedded participant observer. The shadow culture acts to enable the management of the planning process, and its efficacy relates to the ‘quality’ of human inter-relationships amongst immediate stakeholders. Whilst this study uses the concept of shadow culture, it is treated as both a methodological stance and one of the findings of this research in the context of the major construction project in Qatar. The concept of shadow culture is not imposed upon the findings, but instead is used as a research tool: respondents report their own worldview and this is reported from the view of a participant observant in a manner that is understandable and useful to those who are not part of the construction project. The findings of this study identify similar factors influencing the planning process of the Qatar project, but the shadow culture predominantly influences these factors towards the failure of planning process. The research concludes by questioning the assumption that construction planning is a mechanistic process that has to be conducted solely by the planning team. Instead, it is a highly social phenomenon in which the seemingly mechanistic process is made workable by the quality of relationships that exist in the project. Drawing on this the final section provides a series of recommendations that may be helpful in enhancing the efficacy of project planning; these include better training/education at the pre-construction phase; recognition of the importance of shadow processes at management levels, and better appreciation of the impact of contract type and chosen procurement route. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=construction%20planning" title="construction planning">construction planning</a>, <a href="https://publications.waset.org/abstracts/search?q=participant%20observation" title=" participant observation"> participant observation</a>, <a href="https://publications.waset.org/abstracts/search?q=project%20participants" title=" project participants"> project participants</a>, <a href="https://publications.waset.org/abstracts/search?q=shadow%20culture" title=" shadow culture"> shadow culture</a> </p> <a href="https://publications.waset.org/abstracts/87078/investigation-of-the-factors-influencing-the-construction-planning-process-using-participant-observation-method" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/87078.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">122</span> Near Ambient Pressure Photoelectron Spectroscopy Studies of CO Oxidation on Spinel Co3O4 Surfaces: Electronic Structure and Mechanistic Aspects of Wet and Dry CO Oxidation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ruchi%20Jain">Ruchi Jain</a>, <a href="https://publications.waset.org/abstracts/search?q=Chinnakonda%20S.%20Gopinath"> Chinnakonda S. Gopinath</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The CO oxidation is a primary reaction in heterogeneous catalysis due to its potential to overcome the air pollution caused by various reasons. Indeed, in the study of sustainable catalysis, the role played by water is very important. The present work is focused on studying the effect of moisture on the sustainability of Co3O4 NR catalyst for CO oxidation reaction at ambient temperature. The catalytic activity, electronic structure and the mechanistic aspects of spinel Co3O4 nanorod surfaces have been explored in dry and wet atmosphere by near-ambient pressure photoelectron spectroscopic techniques (NAP-PES) with conventional x-ray (Al kα) and ultraviolet sources (He-I).Comparative NAPPES studies have been employed to understand the elucidation of the catalytic reaction pathway and the evolution of various surface species. The presence of water with CO+O2 plummet the catalytic activity due to the change in electronic nature from predominantly oxidic (without water in the feed) to few intermediates covered Co3O4 surface. However, ≥ 375 K Co3O4 surface recovers and regain oxidation activity, at least partially, even in the presence of water. Above mentioned observations are fully supported by the changes observed in the work function of Co3O4 in the presence of wet (H2O+CO+O2) compared to dry (CO+O2) conditions. Various type of surface species, such as CO(ads), carbonate, formate, are found to be on the catalyst surface depending on the reaction conditions. Under dry condition, CO couples with labile O atoms to form CO2, however under wet conditions it also interacts with surface OH groups results in the formation carbonate and formate intermediate. The carbonate acts at reaction inhibitor at room temperature, however proves as active intermediate at temperature 375 K or above. On the other hand, formate has proved to be reaction spectator due to its high stability. The intrinsic role of these species to suppress the oxidation has been demonstrated through a possible reaction mechanism under different reaction conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heterogeneous%20catalysis" title="heterogeneous catalysis">heterogeneous catalysis</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20chemistry" title=" surface chemistry"> surface chemistry</a>, <a href="https://publications.waset.org/abstracts/search?q=photoelectron%20spectroscopy" title=" photoelectron spectroscopy"> photoelectron spectroscopy</a>, <a href="https://publications.waset.org/abstracts/search?q=ambient%20oxidation" title=" ambient oxidation"> ambient oxidation</a> </p> <a href="https://publications.waset.org/abstracts/67118/near-ambient-pressure-photoelectron-spectroscopy-studies-of-co-oxidation-on-spinel-co3o4-surfaces-electronic-structure-and-mechanistic-aspects-of-wet-and-dry-co-oxidation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67118.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">255</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">121</span> Big Data’s Mechanistic View of Human Behavior May Displace Traditional Library Missions That Empower Users</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gabriel%20Gomez">Gabriel Gomez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The very concept of information seeking behavior, and the means by which librarians teach users to gain information, that is information literacy, are at the heart of how libraries deliver information, but big data will forever change human interaction with information and the way such behavior is both studied and taught. Just as importantly, big data will orient the study of behavior towards commercial ends because of a tendency towards instrumentalist views of human behavior, something one might also call a trend towards behaviorism. This oral presentation seeks to explore how the impact of big data on understandings of human behavior might impact a library information science (LIS) view of human behavior and information literacy, and what this might mean for social justice aims and concomitant community action normally at the center of librarianship. The methodology employed here is a non-empirical examination of current understandings of LIS in regards to social justice alongside an examination of the benefits and dangers foreseen with the growth of big data analysis. The rise of big data within the ever-changing information environment encapsulates a shift to a more mechanistic view of human behavior, one that can easily encompass information seeking behavior and information use. As commercial aims displace the important political and ethical aims that are often central to the missions espoused by libraries and the social sciences, the very altruism and power relations found in LIS are at risk. In this oral presentation, an examination of the social justice impulses of librarians regarding power and information demonstrates how such impulses can be challenged by big data, particularly as librarians understand user behavior and promote information literacy. The creeping behaviorist impulse inherent in the emphasis big data places on specific solutions, that is answers to question that ask how, as opposed to larger questions that hint at an understanding of why people learn or use information threaten library information science ideals. Together with the commercial nature of most big data, this existential threat can harm the social justice nature of librarianship. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=big%20data" title="big data">big data</a>, <a href="https://publications.waset.org/abstracts/search?q=library%20information%20science" title=" library information science"> library information science</a>, <a href="https://publications.waset.org/abstracts/search?q=behaviorism" title=" behaviorism"> behaviorism</a>, <a href="https://publications.waset.org/abstracts/search?q=librarianship" title=" librarianship"> librarianship</a> </p> <a href="https://publications.waset.org/abstracts/23254/big-datas-mechanistic-view-of-human-behavior-may-displace-traditional-library-missions-that-empower-users" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/23254.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">383</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">120</span> Computational Insight into a Mechanistic Overview of Water Exchange Kinetics and Thermodynamic Stabilities of Bis and Tris-Aquated Complexes of Lanthanides</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Niharika%20Keot">Niharika Keot</a>, <a href="https://publications.waset.org/abstracts/search?q=Manabendra%20Sarma"> Manabendra Sarma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A thorough investigation of Ln3+ complexes with more than one inner-sphere water molecule is crucial for designing high relaxivity contrast agents (CAs) used in magnetic resonance imaging (MRI). This study accomplished a comparative stability analysis of two hexadentate (H3cbda and H3dpaa) and two heptadentate (H4peada and H3tpaa) ligands with Ln3+ ions. The higher stability of the hexadentate H3cbda and heptadentate H4peada ligands has been confirmed by the binding affinity and Gibbs free energy analysis in aqueous solution. In addition, energy decomposition analysis (EDA) reveals the higher binding affinity of the peada4− ligand than the cbda3− ligand towards Ln3+ ions due to the higher charge density of the peada4− ligand. Moreover, a mechanistic overview of water exchange kinetics has been carried out based on the strength of the metal–water bond. The strength of the metal–water bond follows the trend Gd–O47 (w) > Gd–O39 (w) > Gd–O36 (w) in the case of the tris-aquated [Gd(cbda)(H2O)3] and Gd–O43 (w) > Gd–O40 (w) for the bis-aquated [Gd(peada)(H2O)2]− complex, which was confirmed by bond length, electron density (ρ), and electron localization function (ELF) at the corresponding bond critical points. Our analysis also predicts that the activation energy barrier decreases with the decrease in bond strength; hence kex increases. The 17O and 1H hyperfine coupling constant values of all the coordinated water molecules were different, calculated by using the second-order Douglas–Kroll–Hess (DKH2) approach. Furthermore, the ionic nature of the bonding in the metal–ligand (M–L) bond was confirmed by the Quantum Theory of Atoms-In-Molecules (QTAIM) and ELF along with energy decomposition analysis (EDA). We hope that the results can be used as a basis for the design of highly efficient Gd(III)-based high relaxivity MRI contrast agents for medical applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=MRI%20contrast%20agents" title="MRI contrast agents">MRI contrast agents</a>, <a href="https://publications.waset.org/abstracts/search?q=lanthanide%20chemistry" title=" lanthanide chemistry"> lanthanide chemistry</a>, <a href="https://publications.waset.org/abstracts/search?q=thermodynamic%20stability" title=" thermodynamic stability"> thermodynamic stability</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20exchange%20kinetics" title=" water exchange kinetics"> water exchange kinetics</a> </p> <a href="https://publications.waset.org/abstracts/168516/computational-insight-into-a-mechanistic-overview-of-water-exchange-kinetics-and-thermodynamic-stabilities-of-bis-and-tris-aquated-complexes-of-lanthanides" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/168516.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">83</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">119</span> In vitro and in vivo Anticancer Activity of Nanosize Zinc Oxide Composites of Doxorubicin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emma%20R.%20Arakelova">Emma R. Arakelova</a>, <a href="https://publications.waset.org/abstracts/search?q=Stepan%20G.%20Grigoryan"> Stepan G. Grigoryan</a>, <a href="https://publications.waset.org/abstracts/search?q=Flora%20G.%20Arsenyan"> Flora G. Arsenyan</a>, <a href="https://publications.waset.org/abstracts/search?q=Nelli%20S.%20Babayan"> Nelli S. Babayan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruzanna%20M.%20Grigoryan"> Ruzanna M. Grigoryan</a>, <a href="https://publications.waset.org/abstracts/search?q=Natalia%20K.%20Sarkisyan"> Natalia K. Sarkisyan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Novel nanosize zinc oxide composites of doxorubicin obtained by deposition of 180 nm thick zinc oxide film on the drug surface using DC-magnetron sputtering of a zinc target in the form of gels (PEO+Dox+ZnO and Starch+NaCMC+Dox+ZnO) were studied for drug delivery applications. The cancer specificity was revealed both in in vitro and in vivo models. The cytotoxicity of the test compounds was analyzed against human cancer (HeLa) and normal (MRC5) cell lines using MTT colorimetric cell viability assay. IC50 values were determined and compared to reveal the cancer specificity of the test samples. The mechanistic study of the most active compound was investigated using Flow cytometry analyzing of the DNA content after PI (propidium iodide) staining. Data were analyzed with Tree Star FlowJo software using cell cycle analysis Dean-Jett-Fox module. The in vivo anticancer activity estimation experiments were carried out on mice with inoculated ascitic Ehrlich’s carcinoma at intraperitoneal introduction of doxorubicin and its zinc oxide compositions. It was shown that the nanosize zinc oxide film deposition on the drug surface leads to the selective anticancer activity of composites at the cellular level with the range of selectivity index (SI) from 4 (Starch+NaCMC+Dox+ZnO) to 200 (PEO(gel)+Dox+ZnO) which is higher than that of free Dox (SI = 56). The significant increase in vivo antitumor activity (by a factor of 2-2.5) and decrease of general toxicity of zinc oxide compositions of doxorubicin in the form of the above mentioned gels compared to free doxorubicin were shown on the model of inoculated Ehrlich's ascitic carcinoma. Mechanistic studies of anticancer activity revealed the cytostatic effect based on the high level of DNA biosynthesis inhibition at considerable low concentrations of zinc oxide compositions of doxorubicin. The results of studies in vitro and in vivo behavior of PEO+Dox+ZnO and Starch+NaCMC+Dox+ZnO composites confirm the high potential of the nanosize zinc oxide composites as a vector delivery system for future application in cancer chemotherapy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=anticancer%20activity" title="anticancer activity">anticancer activity</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20specificity" title=" cancer specificity"> cancer specificity</a>, <a href="https://publications.waset.org/abstracts/search?q=doxorubicin" title=" doxorubicin"> doxorubicin</a>, <a href="https://publications.waset.org/abstracts/search?q=zinc%20oxide" title=" zinc oxide"> zinc oxide</a> </p> <a href="https://publications.waset.org/abstracts/1359/in-vitro-and-in-vivo-anticancer-activity-of-nanosize-zinc-oxide-composites-of-doxorubicin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1359.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">411</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">118</span> Tryptophan and Its Derivative Oxidation by Heme-Dioxygenase Enzyme</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ali%20Bahri%20Lubis">Ali Bahri Lubis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tryptophan oxidation by Heme-dioxygenase enzyme is initial important stepTryptophan oxidation by Heme-dioxygenase enzyme is initial important step in kynurenine pathway implicating to several severe diseases such as Parkinson’s Disease, Huntington Disease, poliomyelitis and cataract. It is crucial to comprehend the oxidation mechanism with the hope to find decent treatment upon abovementioned diseases. The mechanism has been debatable since no one has been yet proved the mechanism obviously. In this research we have attempted to prove mechanistic steps of tryptophan oxidation via human indoleamine dioxygenase (h-IDO) using various substrates: L-tryptophan, L-tryptophan (indole-ring-2-13C), L-fully-labelled13C-tryptophan, L-N-methyl-tryptophan, L-tryptophan and 2-amino-3-(benzo(b)thiophene-3-yl) propanoic acid. All enzyme assay experiments were measured using a UV-Vis spectrophotometer, LC-MS, 1H-NMR, and HSQC. We also successfully synthesized enzyme products as our control in NMR measurements. The result exhibited that the distinct substrates produced N-formyl kynurenine (NFK) and hydroxypyrrolloindoleamine carboxylate acid (HPIC) in different concentrations and isomers, correlated to the proposal of considered mechanism reaction in kynurenine pathway implicating to several severe diseases such as Parkinson’s Disease, Huntington Disease, poliomyelitis and cataract. It is crucial to comprehend the oxidation mechanism with the hope to find decent treatment for the abovementioned diseases. The mechanism has been debatable since no one has yet proven the mechanism obviously. In this research we have attempted to prove mechanistic steps of tryptophan oxidation via human indoleamine dioxygenase (h-IDO) using various substrates: L-tryptophan, L-tryptophan (indole-ring-2-13C), L-fully-labelled13C-tryptophan, L-N-methyl-tryptophan, L-tryptophan and 2-amino-3-(benzo(b)thiophene-3-yl) propanoic acid. All enzyme assay experiments were measured using a UV-Vis spectrophotometer, LC-MS, 1H-NMR and HSQC. We also successfully synthesized enzyme products as our control in NMR measurements. The result exhibited that the distinct substrates produced N-formyl kynurenine (NFK) and hydroxypyrrolloindoleamine carboxylate acid (HPIC) in different concentrations and isomers, correlated to the proposal of considered mechanism reaction. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=heme-dioxygenase%20enzyme" title="heme-dioxygenase enzyme">heme-dioxygenase enzyme</a>, <a href="https://publications.waset.org/abstracts/search?q=tryptophan%20oxidation" title=" tryptophan oxidation"> tryptophan oxidation</a>, <a href="https://publications.waset.org/abstracts/search?q=kynurenine%20pathway" title=" kynurenine pathway"> kynurenine pathway</a>, <a href="https://publications.waset.org/abstracts/search?q=n-formyl%20kynurenine" title=" n-formyl kynurenine"> n-formyl kynurenine</a> </p> <a href="https://publications.waset.org/abstracts/169673/tryptophan-and-its-derivative-oxidation-by-heme-dioxygenase-enzyme" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/169673.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">79</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">117</span> Innate Immune Dysfunction in Niemann Pick Disease Type C</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Stephanie%20Newman">Stephanie Newman</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Niemann-Pick Type C disease is a rare, usually fatal lysosomal storage disorder. Although clinically characterized by progressive neurodegeneration, there is also evidence of altered innate immune responses such as neuroinflammation that promote disease progression. We have initiated an investigation into whether phagocytosis, an important innate immune activity and the process by which particles are ingested is defective in NPC. Using an in vitro assay, we have shown that NPC macrophages have a deficiency in the phagocytosis of different particles. We plan to investigate the mechanistic basis for impaired phagocytosis, the contribution that this deficiency makes to disease pathology, and whether therapies that have shown in vivo benefit are able to restore phagocytic activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Niemann%20Pick%20Disease%20C" title="Niemann Pick Disease C">Niemann Pick Disease C</a>, <a href="https://publications.waset.org/abstracts/search?q=phagocytosis" title=" phagocytosis"> phagocytosis</a>, <a href="https://publications.waset.org/abstracts/search?q=innate%20immunity" title=" innate immunity"> innate immunity</a>, <a href="https://publications.waset.org/abstracts/search?q=lysosomal%20storage%20disorder" title=" lysosomal storage disorder "> lysosomal storage disorder </a> </p> <a href="https://publications.waset.org/abstracts/34154/innate-immune-dysfunction-in-niemann-pick-disease-type-c" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34154.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">392</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">116</span> Investigating Water-Oxidation Using a Ru(III) Carboxamide Water Coordinated Complex </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yosra%20M.%20Badiei">Yosra M. Badiei</a>, <a href="https://publications.waset.org/abstracts/search?q=Evelyn%20Ortiz"> Evelyn Ortiz</a>, <a href="https://publications.waset.org/abstracts/search?q=Marisa%20Portenti"> Marisa Portenti</a>, <a href="https://publications.waset.org/abstracts/search?q=David%20Szalda"> David Szalda</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Water-oxidation half-reaction is a critical reaction that can be driven by a sustainable energy source (e.g., solar or wind) and be coupled with a chemical fuel making reaction which stores the released electrons and protons from water (e.g., H₂ or methanol). The use of molecular water-oxidation catalysts (WOC) allow the rationale design of redox active metal centers and provides a better understanding of their structure-activity-relationship. Herein, the structure of a Ru(III) complex bearing a doubly deprotonated N,N'-bis(aryl)pyridine-2,6-dicarboxamide ligand which contains a water molecule in its primary coordination sphere was elucidated by single-crystal X-ray diffraction. Further spectroscopic experimental data and pH-dependent electrochemical studies reveal its water-oxidation reactivity. Emphasis on mechanistic details for O₂ formation of this complex will be addressed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=water-oxidation" title="water-oxidation">water-oxidation</a>, <a href="https://publications.waset.org/abstracts/search?q=catalysis" title=" catalysis"> catalysis</a>, <a href="https://publications.waset.org/abstracts/search?q=ruthenium" title=" ruthenium"> ruthenium</a>, <a href="https://publications.waset.org/abstracts/search?q=artificial%20photosynthesis" title=" artificial photosynthesis"> artificial photosynthesis</a> </p> <a href="https://publications.waset.org/abstracts/108812/investigating-water-oxidation-using-a-ruiii-carboxamide-water-coordinated-complex" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/108812.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">201</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">115</span> Moisture Variations in Unbound Layers in an Instrumented Pavement Section</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=R.%20Islam">R. Islam</a>, <a href="https://publications.waset.org/abstracts/search?q=Rafiqul%20A.%20Tarefder"> Rafiqul A. Tarefder</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study presents the moisture variations of unbound layers from April 2012 to January 2014 in the Interstate 40 (I-40) pavement section in New Mexico. Three moisture probes were installed at different layers inside the pavement which measure the continuous moisture variations of the pavement. Data show that the moisture contents of unbound layers are typically constant throughout the day and month unless there is rainfall. Moisture contents of all unbound layers change with rainfall. Change in ground water table may affect the moisture content of unbound layers which has not investigated in this study. In addition, the Level 3 predictions of moisture contents using the Pavement Mechanistic-Empirical (ME) Design software are compared and found quite reasonable. However, results presented in the current study may not be applicable for pavement in other regions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=asphalt%20pavement" title="asphalt pavement">asphalt pavement</a>, <a href="https://publications.waset.org/abstracts/search?q=moisture%20probes" title=" moisture probes"> moisture probes</a>, <a href="https://publications.waset.org/abstracts/search?q=resilient%20modulus" title=" resilient modulus"> resilient modulus</a>, <a href="https://publications.waset.org/abstracts/search?q=climate%20model" title=" climate model "> climate model </a> </p> <a href="https://publications.waset.org/abstracts/21090/moisture-variations-in-unbound-layers-in-an-instrumented-pavement-section" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21090.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">493</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">114</span> Photochemical Behaviour of Carbamazepine in Natural Waters</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Fanny%20Desbiolles">Fanny Desbiolles</a>, <a href="https://publications.waset.org/abstracts/search?q=Laure%20Malleret"> Laure Malleret</a>, <a href="https://publications.waset.org/abstracts/search?q=Isabelle%20Laffont-Schwob"> Isabelle Laffont-Schwob</a>, <a href="https://publications.waset.org/abstracts/search?q=Christophe%20Tiliacos"> Christophe Tiliacos</a>, <a href="https://publications.waset.org/abstracts/search?q=Anne%20Piram"> Anne Piram</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohamed%20Sarakha"> Mohamed Sarakha</a>, <a href="https://publications.waset.org/abstracts/search?q=Pascal%20Wong-Wah-Chung"> Pascal Wong-Wah-Chung</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Pharmaceuticals in the environment have become a very hot topic in the recent years. This interest is related to the large amounts dispensed and to their release in urine or faeces from treated patients, resulting in their ubiquitous presence in water resources and wastewater treatment plants (WWTP) effluents. Thereby, many studies focused on the prediction of pharmaceuticals’ behaviour, to assess their fate and impacts in the environment. Carbamazepine is a widely consumed psychotropic pharmaceutical, thus being one of the most commonly detected drugs in the environment. This organic pollutant was proved to be persistent, especially with respect to its non-biodegradability, rendering it recalcitrant to usual biological treatment processes. Consequently, carbamazepine is very little removed in WWTP with a maximum abatement rate of 5 % and is then often released in natural surface waters. To better assess the environmental fate of carbamazepine in aqueous media, its photochemical transformation was undertaken in four natural waters (two French rivers, the Berre salt lagoon, Mediterranean Sea water) representative of coastal and inland water types. Kinetic experiments were performed in the presence of light using simulated solar irradiation (Xe lamp 300W). Formation of short-lifetime species was highlighted using chemical trap and laser flash photolysis (nanosecond). Identification of transformation by-products was assessed by LC-QToF-MS analyses. Carbamazepine degradation was observed after a four-day exposure and an abatement of 20% maximum was measured yielding to the formation of many by-products. Moreover, the formation of hydroxyl radicals (•OH) was evidenced in waters using terephthalic acid as a probe, considering the photochemical instability of its specific hydroxylated derivative. Correlations were implemented using carbamazepine degradation rate, estimated hydroxyl radical formation and chemical contents of waters. In addition, laser flash photolysis studies confirmed •OH formation and allowed to evidence other reactive species, such as chloride (Cl2•-)/bromine (Br2•-) and carbonate (CO3•-) radicals in natural waters. Radicals mainly originate from dissolved phase and their occurrence and abundance depend on the type of water. Rate constants between reactive species and carbamazepine were determined by laser flash photolysis and competitive reactions experiments. Moreover, LC-QToF-MS analyses of by-products help us to propose mechanistic pathways. The results will bring insights to the fate of carbamazepine in various water types and could help to evaluate more precisely potential ecotoxicological effects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carbamazepine" title="carbamazepine">carbamazepine</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetic%20and%20mechanistic%20approaches" title=" kinetic and mechanistic approaches"> kinetic and mechanistic approaches</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20waters" title=" natural waters"> natural waters</a>, <a href="https://publications.waset.org/abstracts/search?q=photodegradation" title=" photodegradation"> photodegradation</a> </p> <a href="https://publications.waset.org/abstracts/63769/photochemical-behaviour-of-carbamazepine-in-natural-waters" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63769.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">380</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">113</span> A Unified Model for Orotidine Monophosphate Synthesis: Target for Inhibition of Growth of Mycobacterium tuberculosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Naga%20Subrahmanyeswara%20Rao">N. Naga Subrahmanyeswara Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=Parag%20Arvind%20Deshpande"> Parag Arvind Deshpande</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Understanding nucleotide synthesis reaction of any organism is beneficial to know the growth of it as in Mycobacterium tuberculosis to design anti TB drug. One of the reactions of de novo pathway which takes place in all organisms was considered. The reaction takes places between phosphoribosyl pyrophosphate and orotate catalyzed by orotate phosphoribosyl transferase and divalent metal ion gives orotdine monophosphate, a nucleotide. All the reaction steps of three experimentally proposed mechanisms for this reaction were considered to develop kinetic rate expression. The model was validated using the data for four organisms. This model could successfully describe the kinetics for the reported data. The developed model can serve as a reliable model to describe the kinetics in new organisms without the need of mechanistic determination. So an organism-independent model was developed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mechanism" title="mechanism">mechanism</a>, <a href="https://publications.waset.org/abstracts/search?q=nucleotide" title=" nucleotide"> nucleotide</a>, <a href="https://publications.waset.org/abstracts/search?q=organism" title=" organism"> organism</a>, <a href="https://publications.waset.org/abstracts/search?q=tuberculosis" title=" tuberculosis"> tuberculosis</a> </p> <a href="https://publications.waset.org/abstracts/58551/a-unified-model-for-orotidine-monophosphate-synthesis-target-for-inhibition-of-growth-of-mycobacterium-tuberculosis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58551.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">112</span> Cost Effectiveness and Performance Study of Perpetual Pavement Using ABAQUS</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mansour%20Fakhri">Mansour Fakhri</a>, <a href="https://publications.waset.org/abstracts/search?q=Monire%20Zokaei"> Monire Zokaei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Where there are many demolitions on conventional asphalt pavements, heavy costs are paid to repair and reconstruct the pavement roads annually. Recently some research has been done in order to increase the pavement life. Perpetual pavement is regarded as one of them which can improve the pavement life and minimize the maintenance activity and cost. In this research, ABAQUS which is a finite element software is implemented for analyzing and simulation of perpetual pavement. Viscoelastic model of material is used and loading wheel is considered to be dynamic. Effect of different parameters on pavement function has been considered. Because of high primary cost these pavements are not widely used. In this regard, life cost analysis was also carried out to compare perpetual pavement to conventional asphalt concrete pavement. It was concluded that although the initial cost of perpetual pavement is higher than that of conventional asphalt pavement, life cycle cost analysis during 50 years of service life showed that the performance of this pavement is better and the whole life cost of that is less. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ABAQUS" title="ABAQUS">ABAQUS</a>, <a href="https://publications.waset.org/abstracts/search?q=lifecycle%20cost%20analysis" title=" lifecycle cost analysis"> lifecycle cost analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=mechanistic%20empirical" title=" mechanistic empirical"> mechanistic empirical</a>, <a href="https://publications.waset.org/abstracts/search?q=perpetual%20pavement" title=" perpetual pavement"> perpetual pavement</a> </p> <a href="https://publications.waset.org/abstracts/33524/cost-effectiveness-and-performance-study-of-perpetual-pavement-using-abaqus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33524.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">383</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">111</span> Mechanistic Studies of Compacted and Sintered Rock Salt</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Claudia%20H.%20Swanson">Claudia H. Swanson</a>, <a href="https://publications.waset.org/abstracts/search?q=Jens%20G%C3%BCnster"> Jens Günster</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This research addresses the densification via compaction and sintering of naturally occurring rock salt which was motivated by the fact that in a saline environment rock salt is thermodynamically stable and does show a mechanical behavior compatible to the surrounding host material. The sintering of rock salt powder compacts was systematically investigated using temperature and pressure as variables for the sinter process. The behavior of rock salt showed segregations of anhydrite, CaSO4 - the major impurity found in rock salt, to the grain boundaries between individual sodium chloride crystals. Powder compacts treated with lower pressures lost those anhydrite segregates over time while high pressure treated compacts remained with anhydrite segregates. The density reached in this study is 2.008 g cm-3 corresponding to a density of 92.5 % of the theoretical value. This high density is making the sintering a promising technique for rock salt as applications in underground appropriate environment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=rock%20salt" title="rock salt">rock salt</a>, <a href="https://publications.waset.org/abstracts/search?q=sinter" title=" sinter"> sinter</a>, <a href="https://publications.waset.org/abstracts/search?q=anhydrite" title=" anhydrite"> anhydrite</a>, <a href="https://publications.waset.org/abstracts/search?q=nuclear%20safety" title=" nuclear safety"> nuclear safety</a> </p> <a href="https://publications.waset.org/abstracts/25847/mechanistic-studies-of-compacted-and-sintered-rock-salt" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25847.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">489</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">110</span> Mechanistic Analysis of an L-2-Haloacid Dehalogenase (DehL) from Rhizobium Sp. RC1: Computational Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Aliyu%20Adamu">Aliyu Adamu</a>, <a href="https://publications.waset.org/abstracts/search?q=Fahrul%20Huyop"> Fahrul Huyop</a>, <a href="https://publications.waset.org/abstracts/search?q=Roswanira%20Abdul%20Wahab"> Roswanira Abdul Wahab</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohd%20Shahir%20Shamsir"> Mohd Shahir Shamsir</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Halogenated organic compounds occur in huge amount in biosphere. This is attributable to the diverse use of halogen-based compounds in the synthesis of various industrially important products. Halogenated compound is toxic and may persist in the environment, thereby causing serious health and environmental pollution problems. L-2-haloacid dehalogenases (EC 3.8.1.2) catalyse the specific cleavage of carbon-halogen bond in L-isomers of halogenated compounds, which consequently reverse the effects of environmental halogen-associated pollution. To enhance the efficiency and utility of these enzymes, this study investigates the catalytic amino acid residues and the molecular functional mechanism of DehL, by classical molecular dynamic simulations, MM-PBSA and ab initio fragments molecular orbital (FMO) calculations. The results of the study will serve as the basis for the molecular engineering of the enzyme. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=DehL" title="DehL">DehL</a>, <a href="https://publications.waset.org/abstracts/search?q=Functional%20mechanism" title=" Functional mechanism"> Functional mechanism</a>, <a href="https://publications.waset.org/abstracts/search?q=Catalytic%20residues" title=" Catalytic residues"> Catalytic residues</a>, <a href="https://publications.waset.org/abstracts/search?q=L-2-haloacid%20dehalogenase" title=" L-2-haloacid dehalogenase"> L-2-haloacid dehalogenase</a> </p> <a href="https://publications.waset.org/abstracts/64910/mechanistic-analysis-of-an-l-2-haloacid-dehalogenase-dehl-from-rhizobium-sp-rc1-computational-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/64910.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">364</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">109</span> Oncogenic Functions of Long Non-Coding RNA XIST in Human Nasopharyngeal Carcinoma by Targeting MiR-34a-5p</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cheng-Cao%20Sun">Cheng-Cao Sun</a>, <a href="https://publications.waset.org/abstracts/search?q=Shu-Jun%20Li"> Shu-Jun Li</a>, <a href="https://publications.waset.org/abstracts/search?q=De-Jia%20Li"> De-Jia Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been verified as an oncogenic gene in several human malignant tumors, and its dysregulation was closed associated with tumor initiation, development and progression. Nevertheless, whether the aberrant expression of XIST in human nasopharyngeal carcinoma (NPC) is corrected with malignancy, metastasis or prognosis has not been elaborated. Here, we discovered that XIST was up-regulated in NPC tissues and higher expression of XIST contributed to a markedly poorer survival time. In addition, multivariate analysis demonstrated XIST was an independent risk factor for prognosis. XIST over-expression enhanced, while XIST silencing hampered the cell growth in NPC. Additionally, mechanistic analysis revealed that XIST up-regulated the expression of miR-34a-5p targeted gene E2F3 through acting as a competitive ‘sponge’ of miR-34a-5p. Taking all into account, we concluded that XIST functioned as an oncogene in NPC through up-regulating E2F3 in part through ‘spongeing’ miR-34a-5p. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=X%20inactivate-specific%20transcript%3B%20hsa-miRNA-34a-5p" title="X inactivate-specific transcript; hsa-miRNA-34a-5p">X inactivate-specific transcript; hsa-miRNA-34a-5p</a>, <a href="https://publications.waset.org/abstracts/search?q=miR-34a-5p%3B%20E2F3" title=" miR-34a-5p; E2F3"> miR-34a-5p; E2F3</a>, <a href="https://publications.waset.org/abstracts/search?q=nasopharyngeal%20carcinoma" title=" nasopharyngeal carcinoma"> nasopharyngeal carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=tumorigenesis" title=" tumorigenesis"> tumorigenesis</a> </p> <a href="https://publications.waset.org/abstracts/54940/oncogenic-functions-of-long-non-coding-rna-xist-in-human-nasopharyngeal-carcinoma-by-targeting-mir-34a-5p" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54940.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">240</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">108</span> Removal of Aromatic Fractions of Natural Organic Matter from Synthetic Water Using Aluminium Based Electrocoagulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tanwi%20Priya">Tanwi Priya</a>, <a href="https://publications.waset.org/abstracts/search?q=Brijesh%20Kumar%20Mishra"> Brijesh Kumar Mishra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Occurrence of aromatic fractions of Natural Organic Matter (NOM) led to formation of carcinogenic disinfection by products such as trihalomethanes in chlorinated water. In the present study, the efficiency of aluminium based electrocoagulation on the removal of prominent aromatic groups such as phenol, hydrophobic auxochromes, and carboxyl groups from NOM enriched synthetic water has been evaluated using various spectral indices. The effect of electrocoagulation on turbidity has also been discussed. The variation in coagulation performance as a function of pH has been studied. Our result suggests that electrocoagulation can be considered as appropriate remediation approach to reduce trihalomethanes formation in water. It has effectively reduced hydrophobic fractions from NOM enriched low turbid water. The charge neutralization and enmeshment of dispersed colloidal particles inside metallic hydroxides is the possible mechanistic approach in electrocoagulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aromatic%20fractions" title="aromatic fractions">aromatic fractions</a>, <a href="https://publications.waset.org/abstracts/search?q=electrocoagulation" title=" electrocoagulation"> electrocoagulation</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20organic%20matter" title=" natural organic matter"> natural organic matter</a>, <a href="https://publications.waset.org/abstracts/search?q=spectral%20indices" title=" spectral indices"> spectral indices</a> </p> <a href="https://publications.waset.org/abstracts/71237/removal-of-aromatic-fractions-of-natural-organic-matter-from-synthetic-water-using-aluminium-based-electrocoagulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71237.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">278</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">107</span> The Estimation of Human Vital Signs Complexity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=L.%20Bikulciene">L. Bikulciene</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Venskaityte"> E. Venskaityte</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Jarusevicius"> G. Jarusevicius</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Non-stationary and nonlinear signals generated by living complex systems defy traditional mechanistic approaches, which are based on homeostasis. Previous our studies have shown that the evaluation of the interactions of physiological signals by using special analysis methods is suitable for observation of physiological processes. It is demonstrated the possibility of using deep physiological model, based interpretation of the changes of the human body’s functional states combined with an application of the analytical method based on matrix theory for the physiological signals analysis, which was applied on high risk cardiac patients. It is shown that evaluation of cardiac signals interactions show peculiar for each individual functional changes at the onset of hemodynamic restoration procedure. Therefore we suggest that the alterations of functional state of the body, after patients overcome surgery can be complemented by the data received from the suggested approach of the evaluation of functional variables interactions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cardiac%20diseases" title="cardiac diseases">cardiac diseases</a>, <a href="https://publications.waset.org/abstracts/search?q=complex%20systems%20theory" title=" complex systems theory"> complex systems theory</a>, <a href="https://publications.waset.org/abstracts/search?q=ECG%20analysis" title=" ECG analysis"> ECG analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=matrix%20analysis" title=" matrix analysis"> matrix analysis</a> </p> <a href="https://publications.waset.org/abstracts/1511/the-estimation-of-human-vital-signs-complexity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1511.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">344</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">106</span> Lanthanide Incorporated Dendron Based White Light Emitting Material</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Prashant%20Kumar">Prashant Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Edamana%20Prasad"> Edamana Prasad</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The White light emitting material has an emerging field in recent years due to their widespread application in the field of optoelectronics and cellular display. In the present study, we have achieved white light emission in gel medium through partial resonance energy transfer from different donors (naphthalene, phenanthrene, and pyrene) to lanthanides {Eu(III) and Tb(III)}. The gel was formed by the self- assembly of glucose cored poly(aryl ether) dendrons in DMSO-Water mixture (1:9 v/v). The white light emission was further confirmed by the CIE coordinates (Commission Internationale d’ Eclairage). Moreover, we have developed three different white light emitting system by utilizing three different donor moiety namely, naphthalene-Tb(III)-Eu(III) {I}, phenanthrene-Tb(III)-Eu(III) {II}, and pyrene-Tb(III)-Eu(III) {III}. The CIE coordinates for I, II and III were (0.35, 0.37), (0.33, 0.32) and (0.35, 0.33) respectively. Furthermore, we have investigated the energy transfer from different donors (phenanthrene, naphthalene, and pyrene) to lanthanide {Eu(III)}. The efficiency of energy transfer from phenanthrene-Eu(III), naphthalene-Eu(III) and pyrene-Eu(III) systems was 11.9%, 3.9%, and 3.6%, respectively. Detailed mechanistic aspects will be displayed in the poster. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dendron" title="dendron">dendron</a>, <a href="https://publications.waset.org/abstracts/search?q=lanthanide" title=" lanthanide"> lanthanide</a>, <a href="https://publications.waset.org/abstracts/search?q=resonance%20energy%20transfer" title=" resonance energy transfer"> resonance energy transfer</a>, <a href="https://publications.waset.org/abstracts/search?q=white%20light%20emission" title=" white light emission"> white light emission</a> </p> <a href="https://publications.waset.org/abstracts/63417/lanthanide-incorporated-dendron-based-white-light-emitting-material" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63417.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">105</span> A Data-Driven Compartmental Model for Dengue Forecasting and Covariate Inference</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yichao%20Liu">Yichao Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Peter%20Fransson"> Peter Fransson</a>, <a href="https://publications.waset.org/abstracts/search?q=Julian%20Heidecke"> Julian Heidecke</a>, <a href="https://publications.waset.org/abstracts/search?q=Jonas%20Wallin"> Jonas Wallin</a>, <a href="https://publications.waset.org/abstracts/search?q=Joacim%20Rockloev"> Joacim Rockloev</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dengue, a mosquito-borne viral disease, poses a significant public health challenge in endemic tropical or subtropical countries, including Sri Lanka. To reveal insights into the complexity of the dynamics of this disease and study the drivers, a comprehensive model capable of both robust forecasting and insightful inference of drivers while capturing the co-circulating of several virus strains is essential. However, existing studies mostly focus on only one aspect at a time and do not integrate and carry insights across the siloed approach. While mechanistic models are developed to capture immunity dynamics, they are often oversimplified and lack integration of all the diverse drivers of disease transmission. On the other hand, purely data-driven methods lack constraints imposed by immuno-epidemiological processes, making them prone to overfitting and inference bias. This research presents a hybrid model that combines machine learning techniques with mechanistic modelling to overcome the limitations of existing approaches. Leveraging eight years of newly reported dengue case data, along with socioeconomic factors, such as human mobility, weekly climate data from 2011 to 2018, genetic data detecting the introduction and presence of new strains, and estimates of seropositivity for different districts in Sri Lanka, we derive a data-driven vector (SEI) to human (SEIR) model across 16 regions in Sri Lanka at the weekly time scale. By conducting ablation studies, the lag effects allowing delays up to 12 weeks of time-varying climate factors were determined. The model demonstrates superior predictive performance over a pure machine learning approach when considering lead times of 5 and 10 weeks on data withheld from model fitting. It further reveals several interesting interpretable findings of drivers while adjusting for the dynamics and influences of immunity and introduction of a new strain. The study uncovers strong influences of socioeconomic variables: population density, mobility, household income and rural vs. urban population. The study reveals substantial sensitivity to the diurnal temperature range and precipitation, while mean temperature and humidity appear less important in the study location. Additionally, the model indicated sensitivity to vegetation index, both max and average. Predictions on testing data reveal high model accuracy. Overall, this study advances the knowledge of dengue transmission in Sri Lanka and demonstrates the importance of incorporating hybrid modelling techniques to use biologically informed model structures with flexible data-driven estimates of model parameters. The findings show the potential to both inference of drivers in situations of complex disease dynamics and robust forecasting models. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=compartmental%20model" title="compartmental model">compartmental model</a>, <a href="https://publications.waset.org/abstracts/search?q=climate" title=" climate"> climate</a>, <a href="https://publications.waset.org/abstracts/search?q=dengue" title=" dengue"> dengue</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a>, <a href="https://publications.waset.org/abstracts/search?q=social-economic" title=" social-economic"> social-economic</a> </p> <a href="https://publications.waset.org/abstracts/169664/a-data-driven-compartmental-model-for-dengue-forecasting-and-covariate-inference" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/169664.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">84</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=mechanistic&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=mechanistic&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=mechanistic&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=mechanistic&page=5">5</a></li> <li class="page-item"><a class="page-link" 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