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Sobrinho</title> <meta name="description" content="Search results for: Sobrinho"> <meta name="keywords" content="Sobrinho"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Sobrinho"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 11</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Sobrinho</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">11</span> Fatty Acid Profile of Meat from Lambs Fed on Diets Containing Mulberry Hay</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20G.%20Silva%20Sobrinho">A. G. Silva Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20G.%20A.%20Cirne"> L. G. A. Cirne</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20T.%20Santana"> V. T. Santana</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this trial was to evaluate fatty acid profile of meat from lambs fed on diets containing 0, 12.5 and 25.0% mulberry hay as a substitute for the concentrate. Twenty-four feedlot Ile de France lambs (average weight of 15kg and average age of 60 days) were randomized to receive the different diets and slaughtered at 32kg body weight. Increases were observed in the concentrations of the saturated pentadecanoic, heptadecanoic and arachidic fatty acids; of the monounsaturated nervonic fatty acid and of the polyunsaturated α-linolenic, ɣ-linolenic and eicosapentaenoic fatty acids. Increased conjugated linoleic acid (CLA) was also found in the meat of lambs fed on 12.5% mulberry hay. In addition, the omega-3 composition was augmented, while the omega-3/omega-6 ratio was decreased in mulberry hay-fed animals. In conclusion, a more desirable fatty acid profile was observed in lamb meat following the substitution of mulberry hay in the concentrate of fed, resulting in improved nutritional characteristics of the meat. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=alternative%20food" title="alternative food">alternative food</a>, <a href="https://publications.waset.org/abstracts/search?q=fatty%20acids" title=" fatty acids"> fatty acids</a>, <a href="https://publications.waset.org/abstracts/search?q=feedlot" title=" feedlot"> feedlot</a>, <a href="https://publications.waset.org/abstracts/search?q=sheep%20meat" title=" sheep meat"> sheep meat</a> </p> <a href="https://publications.waset.org/abstracts/9723/fatty-acid-profile-of-meat-from-lambs-fed-on-diets-containing-mulberry-hay" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9723.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">465</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">10</span> A New Family of Flying Wing Low Reynolds Number Airfoils</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ciro%20Sobrinho%20Campolina%20Martins">Ciro Sobrinho Campolina Martins</a>, <a href="https://publications.waset.org/abstracts/search?q=Halison%20da%20Silva%20Pereira"> Halison da Silva Pereira</a>, <a href="https://publications.waset.org/abstracts/search?q=Vitor%20Mainenti%20Leal%20Lopes"> Vitor Mainenti Leal Lopes</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Unmanned Aerial vehicles (UAVs) has been used in a wide range of applications, from precise agriculture monitoring for irrigation and fertilization to military attack missions. Long range performance is required for many of these applications. Tailless aircrafts are commonly used as long-range configurations and, due to its small amount of stability, the airfoil shape design of its wings plays a central role on the performance of the airplane. In this work, a new family of flying wing airfoils is designed for low Reynolds number flows, typical of small-middle UAVs. Camber, thickness and their maximum positions in the chord are variables used for the airfoil geometry optimization. Aerodynamic non-dimensional coefficients were obtained by the well-established Panel Method. High efficient airfoils with small pitch moment coefficient are obtained from the analysis described and its aerodynamic polars are plotted. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=airfoil%20design" title="airfoil design">airfoil design</a>, <a href="https://publications.waset.org/abstracts/search?q=flying%20wing" title=" flying wing"> flying wing</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20Reynolds%20number" title=" low Reynolds number"> low Reynolds number</a>, <a href="https://publications.waset.org/abstracts/search?q=tailless%20aircraft" title=" tailless aircraft"> tailless aircraft</a>, <a href="https://publications.waset.org/abstracts/search?q=UAV" title=" UAV"> UAV</a> </p> <a href="https://publications.waset.org/abstracts/33946/a-new-family-of-flying-wing-low-reynolds-number-airfoils" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33946.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">629</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">9</span> Qualitative Characteristics of Meat from Lambs Fed Hydrolyzed Sugarcane</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=V.%20Endo">V. Endo</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20G.%20Silva%20Sobrinho"> A. G. Silva Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20A.%20Almeida"> F. A. Almeida</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20L.%20L.%20Lima"> N. L. L. Lima</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20M.%20Manzi"> G. M. Manzi</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20G.%20A.%20Cirne"> L. G. A. Cirne</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20M.%20B.%20L.%20Zeola"> N. M. B. L. Zeola</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We used 24 Ile de France lambs, weighing between 15 and 32 kg (BW). Treatments were supplemented with concentrate: “in nature” sugarcane (IN), sugarcane hydrolyzed using 0.6% calcium oxide (CaO) under aerobic condition (AER), and sugarcane hydrolyzed using 0.6% CaO under anaerobic condition (ANA), constituting a completely randomized design with eight repetitions per treatment. Lambs were housed in individual stalls and fed into the through, allowing 10% of leftovers. Lambs were slaughtered when body weight reached 32 kg. The following parameters were determined on Longissimus lumborum muscle of hot and cold carcasses: pH and color, 45 minutes and 24 hours after slaughtering. Qualitative analysis of the meat were performed in the loins, water-holding capacity (WHC), cooking loss (CL), and shear force (SF). We used a completely randomized design with three treatments and eight repetitions. Means were compared by Tukey test at 5% significance. A higher value for redness (a*) 45 minutes after slaughter (10.48) was found for lambs fed sugarcane hydrolyzed under anaerobic conditions. The other qualitative characteristics of meat were not affected by treatments (P >0.05). The comparison of meat quality resulting from the treatments shows that it is possible to feed in nature sugarcane to lambs, thus waiving hydrolyses process and the spending with alkalizing agent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=oxide" title="oxide">oxide</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrolysis" title=" hydrolysis"> hydrolysis</a>, <a href="https://publications.waset.org/abstracts/search?q=meat%20quality" title=" meat quality"> meat quality</a>, <a href="https://publications.waset.org/abstracts/search?q=pH" title=" pH"> pH</a> </p> <a href="https://publications.waset.org/abstracts/6261/qualitative-characteristics-of-meat-from-lambs-fed-hydrolyzed-sugarcane" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/6261.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">563</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Aerodynamic Design of a Light Long Range Blended Wing Body Unmanned Vehicle</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Halison%20da%20Silva%20Pereira">Halison da Silva Pereira</a>, <a href="https://publications.waset.org/abstracts/search?q=Ciro%20Sobrinho%20Campolina%20Martins"> Ciro Sobrinho Campolina Martins</a>, <a href="https://publications.waset.org/abstracts/search?q=Vitor%20Mainenti%20Leal%20Lopes"> Vitor Mainenti Leal Lopes</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Long range performance is a goal for aircraft configuration optimization. Blended Wing Body (BWB) is presented in many works of literature as the most aerodynamically efficient design for a fixed-wing aircraft. Because of its high weight to thrust ratio, BWB is the ideal configuration for many Unmanned Aerial Vehicle (UAV) missions on geomatics applications. In this work, a BWB aerodynamic design for typical light geomatics payload is presented. Aerodynamic non-dimensional coefficients are predicted using low Reynolds number computational techniques (3D Panel Method) and wing parameters like aspect ratio, taper ratio, wing twist and sweep are optimized for high cruise performance and flight quality. The methodology of this work is a summary of tailless aircraft wing design and its application, with appropriate computational schemes, to light UAV subjected to low Reynolds number flows leads to conclusions like the higher performance and flight quality of thicker airfoils in the airframe body and the benefits of using aerodynamic twist rather than just geometric. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=blended%20wing%20body" title="blended wing body">blended wing body</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20Reynolds%20number" title=" low Reynolds number"> low Reynolds number</a>, <a href="https://publications.waset.org/abstracts/search?q=panel%20method" title=" panel method"> panel method</a>, <a href="https://publications.waset.org/abstracts/search?q=UAV" title=" UAV"> UAV</a> </p> <a href="https://publications.waset.org/abstracts/33948/aerodynamic-design-of-a-light-long-range-blended-wing-body-unmanned-vehicle" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33948.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">586</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> Evaluation of Produced Water Treatment Using Advanced Oxidation Processes and Sodium Ferrate(VI)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Erica%20T.%20R.%20Mendon%C3%A7a">Erica T. R. Mendonça</a>, <a href="https://publications.waset.org/abstracts/search?q=Caroline%20M.%20B.%20de%20Araujo"> Caroline M. B. de Araujo</a>, <a href="https://publications.waset.org/abstracts/search?q=Filho"> Filho</a>, <a href="https://publications.waset.org/abstracts/search?q=Osvaldo%20Chiavone"> Osvaldo Chiavone</a>, <a href="https://publications.waset.org/abstracts/search?q=Sobrinho"> Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=Maur%C3%ADcio%20A.%20da%20Motta"> Maurício A. da Motta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oil and gas exploration is an essential activity for modern society, although the supply of its global demand has caused enough damage to the environment, mainly due to produced water generation, which is an effluent associated with the oil and gas produced during oil extraction. It is the aim of this study to evaluate the treatment of produced water, in order to reduce its oils and greases content (OG), by using flotation as a pre-treatment, combined with oxidation for the remaining organic load degradation. Thus, there has been tested Advanced Oxidation Process (AOP) using both Fenton and photo-Fenton reactions, as well as a chemical oxidation treatment using sodium ferrate(VI), Na<sub>2</sub>[FeO<sub>4</sub>], as a strong oxidant. All the studies were carried out using real samples of produced water from petroleum industry. The oxidation process using ferrate(VI) ion was studied based on factorial experimental designs. The factorial design was used in order to study how the variables pH, temperature and concentration of Na<sub>2</sub>[FeO<sub>4</sub>] influences the O&G levels. For the treatment using ferrate(VI) ion, the results showed that the best operating point is obtained when the temperature is 28 °C, pH 3, and a 2000 mg.L<sup>-1</sup> solution of Na<sub>2</sub>[FeO<sub>4</sub>] is used. This experiment has achieved a final O&G level of 4.7 mg.L<sup>-1</sup>, which means 94% percentage removal efficiency of oils and greases. Comparing Fenton and photo-Fenton processes, it was observed that the Fenton reaction did not provide good reduction of O&G (around 20% only). On the other hand, a degradation of approximately 80.5% of oil and grease was obtained after a period of seven hours of treatment using photo-Fenton process, which indicates that the best process combination has occurred between the flotation and the photo-Fenton reaction using solar radiation, with an overall removal efficiency of O&G of approximately 89%. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=advanced%20oxidation%20process" title="advanced oxidation process">advanced oxidation process</a>, <a href="https://publications.waset.org/abstracts/search?q=ferrate%20%28VI%29%20ion" title=" ferrate (VI) ion"> ferrate (VI) ion</a>, <a href="https://publications.waset.org/abstracts/search?q=oils%20and%20greases%20removal" title=" oils and greases removal"> oils and greases removal</a>, <a href="https://publications.waset.org/abstracts/search?q=produced%20water%20treatment" title=" produced water treatment"> produced water treatment</a> </p> <a href="https://publications.waset.org/abstracts/60316/evaluation-of-produced-water-treatment-using-advanced-oxidation-processes-and-sodium-ferratevi" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/60316.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">319</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> GBKMeans: A Genetic Based K-Means Applied to the Capacitated Planning of Reading Units </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anderson%20S.%20Fonseca">Anderson S. Fonseca</a>, <a href="https://publications.waset.org/abstracts/search?q=Italo%20F.%20S.%20Da%20Silva"> Italo F. S. Da Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20D.%20A.%20Santos"> Robert D. A. Santos</a>, <a href="https://publications.waset.org/abstracts/search?q=Mayara%20G.%20Da%20Silva"> Mayara G. Da Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Pedro%20H.%20C.%20Vieira"> Pedro H. C. Vieira</a>, <a href="https://publications.waset.org/abstracts/search?q=Antonio%20M.%20S.%20Sobrinho"> Antonio M. S. Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=Victor%20H.%20B.%20Lemos"> Victor H. B. Lemos</a>, <a href="https://publications.waset.org/abstracts/search?q=Petterson%20%20S.%20Diniz"> Petterson S. Diniz</a>, <a href="https://publications.waset.org/abstracts/search?q=Anselmo%20C.%20Paiva"> Anselmo C. Paiva</a>, <a href="https://publications.waset.org/abstracts/search?q=Eliana%20M.%20G.%20Monteiro"> Eliana M. G. Monteiro</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In Brazil, the National Electric Energy Agency (ANEEL) establishes that electrical energy companies are responsible for measuring and billing their customers. Among these regulations, it’s defined that a company must bill your customers within 27-33 days. If a relocation or a change of period is required, the consumer must be notified in writing, in advance of a billing period. To make it easier to organize a workday’s measurements, these companies create a reading plan. These plans consist of grouping customers into reading groups, which are visited by an employee responsible for measuring consumption and billing. The creation process of a plan efficiently and optimally is a capacitated clustering problem with constraints related to homogeneity and compactness, that is, the employee’s working load and the geographical position of the consuming unit. This process is a work done manually by several experts who have experience in the geographic formation of the region, which takes a large number of days to complete the final planning, and because it’s human activity, there is no guarantee of finding the best optimization for planning. In this paper, the GBKMeans method presents a technique based on K-Means and genetic algorithms for creating a capacitated cluster that respects the constraints established in an efficient and balanced manner, that minimizes the cost of relocating consumer units and the time required for final planning creation. The results obtained by the presented method are compared with the current planning of a real city, showing an improvement of 54.71% in the standard deviation of working load and 11.97% in the compactness of the groups. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=capacitated%20clustering" title="capacitated clustering">capacitated clustering</a>, <a href="https://publications.waset.org/abstracts/search?q=k-means" title=" k-means"> k-means</a>, <a href="https://publications.waset.org/abstracts/search?q=genetic%20algorithm" title=" genetic algorithm"> genetic algorithm</a>, <a href="https://publications.waset.org/abstracts/search?q=districting%20problems" title=" districting problems"> districting problems</a> </p> <a href="https://publications.waset.org/abstracts/111421/gbkmeans-a-genetic-based-k-means-applied-to-the-capacitated-planning-of-reading-units" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/111421.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">198</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> Enhanced Kinetic Solubility Profile of Epiisopiloturine Solid Solution in Hipromellose Phthalate</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amanda%20C.%20Q.%20M.%20Vieira">Amanda C. Q. M. Vieira</a>, <a href="https://publications.waset.org/abstracts/search?q=Cybelly%20M.%20Melo"> Cybelly M. Melo</a>, <a href="https://publications.waset.org/abstracts/search?q=Camila%20B.%20M.%20Figueir%C3%AAdo"> Camila B. M. Figueirêdo</a>, <a href="https://publications.waset.org/abstracts/search?q=Giovanna%20C.%20R.%20M.%20Schver"> Giovanna C. R. M. Schver</a>, <a href="https://publications.waset.org/abstracts/search?q=Salvana%20P.%20M.%20Costa"> Salvana P. M. Costa</a>, <a href="https://publications.waset.org/abstracts/search?q=Magaly%20A.%20M.%20de%20Lyra"> Magaly A. M. de Lyra</a>, <a href="https://publications.waset.org/abstracts/search?q=Ping%20I.%20Lee"> Ping I. Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Jos%C3%A9%20L.%20Soares-Sobrinho"> José L. Soares-Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=Pedro%20J.%20Rolim-Neto"> Pedro J. Rolim-Neto</a>, <a href="https://publications.waset.org/abstracts/search?q=M%C3%B4nica%20F.%20R.%20Soares"> Mônica F. R. Soares</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Epiisopiloturine (EPI) is a drug candidate that is extracted from Pilocarpus microphyllus and isolated from the waste of Pilocarpine. EPI has demonstrated promising schistosomicidal, leishmanicide, anti-inflammatory and antinociceptive activities, according to in vitro studies that have been carried out since 2009. However, this molecule shows poor aqueous solubility, which represents a problem for the release of the drug candidate and its absorption by the organism. The purpose of the present study is to investigate the extent of enhancement of kinetic solubility of a solid solution (SS) of EPI in hipromellose phthalate HP-55 (HPMCP), an enteric polymer carrier. SS was obtained by the solvent evaporation methodology, using acetone/methanol (60:40) as solvent system. Both EPI and polymer (drug loading 10%) were dissolved in this solvent until a clear solution was obtained, and then dried in oven at 60ºC during 12 hours, followed by drying in a vacuum oven for 4 h. The results show a considerable modification in the crystalline structure of the drug candidate. For instance, X-ray diffraction (XRD) shows a crystalline behavior for the EPI, which becomes amorphous for the SS. Polarized light microscopy, a more sensitive technique than XRD, also shows completely absence of crystals in SS sample. Differential Scanning Calorimetric (DSC) curves show no signal of EPI melting point in SS curve, indicating, once more, no presence of crystal in this system. Interaction between the drug candidate and the polymer were found in Infrared microscopy, which shows a carbonyl 43.3 cm-1 band shift, indicating a moderate-strong interaction between them, probably one of the reasons to the SS formation. Under sink conditions (pH 6.8), EPI SS had its dissolution performance increased in 2.8 times when compared with the isolated drug candidate. EPI SS sample provided a release of more than 95% of the drug candidate in 15 min, whereas only 45% of EPI (alone) could be dissolved in 15 min and 70% in 90 min. Thus, HPMCP demonstrates to have a good potential to enhance the kinetic solubility profile of EPI. Future studies to evaluate the stability of SS are required to conclude the benefits of this system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=epiisopiloturine" title="epiisopiloturine">epiisopiloturine</a>, <a href="https://publications.waset.org/abstracts/search?q=hipromellose%20phthalate%20HP-55" title=" hipromellose phthalate HP-55"> hipromellose phthalate HP-55</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmaceuticaltechnology" title=" pharmaceuticaltechnology"> pharmaceuticaltechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=solubility" title=" solubility"> solubility</a> </p> <a href="https://publications.waset.org/abstracts/25673/enhanced-kinetic-solubility-profile-of-epiisopiloturine-solid-solution-in-hipromellose-phthalate" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25673.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">607</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Obtainment of Systems with Efavirenz and Lamellar Double Hydroxide as an Alternative for Solubility Improvement of the Drug</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Danilo%20A.%20F.%20Fontes">Danilo A. F. Fontes</a>, <a href="https://publications.waset.org/abstracts/search?q=Magaly%20A.%20M.Lyra"> Magaly A. M.Lyra</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20L.%20C.%20Moura"> Maria L. C. Moura</a>, <a href="https://publications.waset.org/abstracts/search?q=Leslie%20R.%20M.%20Ferraz"> Leslie R. M. Ferraz</a>, <a href="https://publications.waset.org/abstracts/search?q=Salvana%20P.%20M.%20Costa"> Salvana P. M. Costa</a>, <a href="https://publications.waset.org/abstracts/search?q=Amanda%20C.%20Q.%20M.%20Vieira"> Amanda C. Q. M. Vieira</a>, <a href="https://publications.waset.org/abstracts/search?q=Larissa%20A.%20Rolim"> Larissa A. Rolim</a>, <a href="https://publications.waset.org/abstracts/search?q=Giovanna%20C.%20R.%20M.%20Schver"> Giovanna C. R. M. Schver</a>, <a href="https://publications.waset.org/abstracts/search?q=Ping%20I.%20Lee"> Ping I. Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Severino%20Alves-J%C3%BAnior"> Severino Alves-Júnior</a>, <a href="https://publications.waset.org/abstracts/search?q=Jos%C3%A9%20L.%20Soares-Sobrinho"> José L. Soares-Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=Pedro%20J.%20Rolim-Neto"> Pedro J. Rolim-Neto </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Efavirenz (EFV) is a first-choice drug in antiretroviral therapy with high efficacy in the treatment of infection by Human Immunodeficiency Virus, which causes Acquired Immune Deficiency Syndrome (AIDS). EFV has low solubility in water resulting in a decrease in the dissolution rate and, consequently, in its bioavailability. Among the technological alternatives to increase solubility, the Lamellar Double Hydroxides (LDH) have been applied in the development of systems with poorly water-soluble drugs. The use of analytical techniques such as X-Ray Diffraction (XRD), Infrared Spectroscopy (IR) and Differential Scanning Calorimetry (DSC) allowed the elucidation of drug interaction with the lamellar compounds. The objective of this work was to characterize and develop the binary systems with EFV and LDH in order to increase the solubility of the drug. The LDH-CaAl was synthesized by the method of co-precipitation from salt solutions of calcium nitrate and aluminum nitrate in basic medium. The systems EFV-LDH and their physical mixtures (PM) were obtained at different concentrations (5-60% of EFV) using the solvent technique described by Takahashi & Yamaguchi (1991). The characterization of the systems and the PM’s was performed by XRD techniques, IR, DSC and dissolution test under non-sink conditions. The results showed improvements in the solubility of EFV when associated with LDH, due to a possible change in its crystal structure and formation of an amorphous material. From the DSC results, one could see that the endothermic peak at 173°C, temperature that correspond to the melting process of EFZ in the crystal form, was present in the PM results. For the EFZ-LDH systems (with 5, 10 and 30% of drug loading), this peak was not observed. XRD profiles of the PM showed well-defined peaks for EFV. Analyzing the XRD patterns of the systems, it was found that the XRD profiles of all the systems showed complete attenuation of the characteristic peaks of the crystalline form of EFZ. The IR technique showed that, in the results of the PM, there was the appearance of one band and overlap of other bands, while the IR results of the systems with 5, 10 and 30% drug loading showed the disappearance of bands and a few others with reduced intensity. The dissolution test under non-sink conditions showed that systems with 5, 10 and 30% drug loading promoted a great increase in the solubility of EFV, but the system with 10% of drug loading was the only one that could keep substantial amount of drug in solution at different pHs. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Efavirenz" title="Efavirenz">Efavirenz</a>, <a href="https://publications.waset.org/abstracts/search?q=Lamellar%20Double%20Hydroxides" title=" Lamellar Double Hydroxides"> Lamellar Double Hydroxides</a>, <a href="https://publications.waset.org/abstracts/search?q=Pharmaceutical%20Techonology" title=" Pharmaceutical Techonology"> Pharmaceutical Techonology</a>, <a href="https://publications.waset.org/abstracts/search?q=Solubility" title=" Solubility"> Solubility</a> </p> <a href="https://publications.waset.org/abstracts/25692/obtainment-of-systems-with-efavirenz-and-lamellar-double-hydroxide-as-an-alternative-for-solubility-improvement-of-the-drug" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/25692.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">583</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> Preliminary Study of Water-Oil Separation Process in Three-Phase Separators Using Factorial Experimental Designs and Simulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Caroline%20M.%20B.%20De%20Araujo">Caroline M. B. De Araujo</a>, <a href="https://publications.waset.org/abstracts/search?q=Helenise%20A.%20Do%20Nascimento"> Helenise A. Do Nascimento</a>, <a href="https://publications.waset.org/abstracts/search?q=Claudia%20J.%20Da%20S.%20Cavalcanti"> Claudia J. Da S. Cavalcanti</a>, <a href="https://publications.waset.org/abstracts/search?q=Mauricio%20A.%20Da%20Motta%20Sobrinho"> Mauricio A. Da Motta Sobrinho</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20F.%20Pimentel"> Maria F. Pimentel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Oil production is often followed by the joint production of water and gas. During the journey up to the surface, due to severe conditions of temperature and pressure, the mixing between these three components normally occurs. Thus, the three phases separation process must be one of the first steps to be performed after crude oil extraction, where the water-oil separation is the most complex and important step, since the presence of water into the process line can increase corrosion and hydrates formation. A wide range of methods can be applied in order to proceed with oil-water separation, being more commonly used: flotation, hydrocyclones, as well as the three phase separator vessels. Facing what has been presented so far, it is the aim of this paper to study a system consisting of a three-phase separator, evaluating the influence of three variables: temperature, working pressure and separator type, for two types of oil (light and heavy), by performing two factorial design plans 23, in order to find the best operating condition. In this case, the purpose is to obtain the greatest oil flow rate in the product stream (m3/h) as well as the lowest percentage of water in the oil stream. The simulation of the three-phase separator was performed using Aspen Hysys®2006 simulation software in stationary mode, and the evaluation of the factorial experimental designs was performed using the software Statistica®. From the general analysis of the four normal probability plots of effects obtained, it was observed that interaction effects of two and three factors did not show statistical significance at 95% confidence, since all the values were very close to zero. Similarly, the main effect "separator type" did not show significant statistical influence in any situation. As in this case, it has been assumed that the volumetric flow of water, oil and gas were equal in the inlet stream, the effect separator type, in fact, may not be significant for the proposed system. Nevertheless, the main effect “temperature” was significant for both responses (oil flow rate and mass fraction of water in the oil stream), considering both light and heavy oil, so that the best operation condition occurs with the temperature at its lowest level (30oC), since the higher the temperature, the liquid oil components pass into the vapor phase, going to the gas stream. Furthermore, the higher the temperature, the higher the formation water vapor, so that ends up going into the lighter stream (oil stream), making the separation process more difficult. Regarding the “working pressure”, this effect showed to be significant only for the oil flow rate, so that the best operation condition occurs with the pressure at its highest level (9bar), since a higher operating pressure, in this case, indicated a lower pressure drop inside the vessel, generating lower level of turbulence inside the separator. In conclusion, the best-operating condition obtained for the proposed system, at the studied range, occurs for temperature is at its lowest level and the working pressure is at its highest level. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=factorial%20experimental%20design" title="factorial experimental design">factorial experimental design</a>, <a href="https://publications.waset.org/abstracts/search?q=oil%20production" title=" oil production"> oil production</a>, <a href="https://publications.waset.org/abstracts/search?q=simulation" title=" simulation"> simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=three-phase%20separator" title=" three-phase separator"> three-phase separator</a> </p> <a href="https://publications.waset.org/abstracts/56766/preliminary-study-of-water-oil-separation-process-in-three-phase-separators-using-factorial-experimental-designs-and-simulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/56766.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">289</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Heterotopic Ossification: DISH and Myositis Ossificans in Human Remains Identification</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Patricia%20Shirley%20Almeida%20Prado">Patricia Shirley Almeida Prado</a>, <a href="https://publications.waset.org/abstracts/search?q=Liz%20Brito"> Liz Brito</a>, <a href="https://publications.waset.org/abstracts/search?q=Selma%20Paix%C3%A3o%20Argollo"> Selma Paixão Argollo</a>, <a href="https://publications.waset.org/abstracts/search?q=Gracie%20Moreira"> Gracie Moreira</a>, <a href="https://publications.waset.org/abstracts/search?q=Leticia%20Matos%20Sobrinho"> Leticia Matos Sobrinho</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diffuse idiopathic skeletal hyperostosis (DISH) is a degenerative bone disease also known as Forestier´s disease and ankylosing hyperostosis of the spine is characterized by a tendency toward ossification of half the anterior longitudinal spinal ligament without intervertebral disc disease. DISH is not considered to be osteoarthritis, although the two conditions commonly occur together. Diagnostic criteria include fusion of at least four vertebrae by bony bridges arising from the anterolateral aspect of the vertebral bodies. These vertebral bodies have a 'dripping candle wax' appearance, also can be seen periosteal new bone formation on the anterior surface of the vertebral bodies and there is no ankylosis at zygoapophyseal facet joint. Clinically, patients with DISH tend to be asymptomatic some patients mention moderate pain and stiffness in upper back. This disease is more common in man, uncommon in patients younger than 50 years and rare in patients under 40 years old. In modern populations, DISH is found in association with obesity, (type II) diabetes; abnormal vitamin A metabolism and also associated with higher levels of serum uric acid. There is also some association between the increase of risk of stroke or other cerebrovascular disease. The DISH condition can be confused with Heterotopic Ossification, what is the bone formation in the soft tissues as the result of trauma, wounding, surgery, burnings, prolonged immobility and some central nervous system disorder. All these conditions have been described extensively as myositis ossificans which can be confused with the fibrodysplasia (myositis) ossificans progressive. As in the DISH symptomatology it can be asymptomatic or extensive enough to impair joint function. A third confusion osteoarthritis disease that can bring confusion are the enthesopathies that occur in the entire skeleton being common on the ischial tuberosities, iliac crests, patellae, and calcaneus. Ankylosis of the sacroiliac joint by bony bridges may also be found. CASE 1: this case is skeletal remains presenting skull, some vertebrae and scapulae. This case remains unidentified and due to lack of bone remains. Sex, age and ancestry profile was compromised, however the DISH pathognomonic findings and diagnostic helps to estimate sex and age characteristics. Moreover to presenting DISH these skeletal remains also showed some bone alterations and non-metrics as fusion of the first vertebrae with occipital bone, maxillae and palatine torus and scapular foramen on the right scapulae. CASE 2: this skeleton remains shows an extensive bone heterotopic ossification on the great trochanter area of left femur, right fibula showed a healed fracture in its body however in its inteosseous crest there is an extensive bone growth, also in the Ilium at the region of inferior gluteal line can be observed some pronounced bone growth and the skull presented a pronounced mandibular, maxillary and palatine torus. Despite all these pronounced heterotopic ossification the whole skeleton presents moderate bone overgrowth that is not linked with aging, since the skeleton belongs to a young unidentified individual. The appropriate osteopathological diagnosis support the human identification process through medical reports and also assist with epidemiological data that can strengthen vulnerable anthropological estimates. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone%20disease" title="bone disease">bone disease</a>, <a href="https://publications.waset.org/abstracts/search?q=DISH" title=" DISH"> DISH</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20identification" title=" human identification"> human identification</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20remains" title=" human remains"> human remains</a> </p> <a href="https://publications.waset.org/abstracts/53139/heterotopic-ossification-dish-and-myositis-ossificans-in-human-remains-identification" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/53139.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">333</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Unidentified Remains with Extensive Bone Disease without a Clear Diagnosis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Patricia%20Shirley%20Almeida%20Prado">Patricia Shirley Almeida Prado</a>, <a href="https://publications.waset.org/abstracts/search?q=Selma%20Paix%C3%A3o%20Argollo"> Selma Paixão Argollo</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20De%20F%C3%A1tima%20Teixeira%20Guimar%C3%A3es"> Maria De Fátima Teixeira Guimarães</a>, <a href="https://publications.waset.org/abstracts/search?q=Leticia%20Matos%20Sobrinho"> Leticia Matos Sobrinho</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Skeletal differential diagnosis is essential in forensic anthropology in order to differentiate skeletal trauma from normal osseous variation and pathological processes. Thus, part of forensic anthropological field is differentiate skeletal criminal injuries from the normal skeletal variation (bone fusion or nonunion, transitional vertebrae and other non-metric traits), non-traumatic skeletal pathology (myositis ossificans, arthritis, bone metastasis, osteomyelitis) from traumatic skeletal pathology (myositis ossificans traumatic) avoiding misdiagnosis. This case shows the importance of effective pathological diagnosis in order to accelerate the identification process of skeletonized human remains. THE CASE: An unidentified skeletal remains at the medico legal institute Nina Rodrigues-Salvador, of a male young adult (29 to 40 years estimated) showing a massive heterotopic ossification on its right tibia at upper epiphysis and adjacent articular femur surface; an extensive ossification on the right clavicle (at the sternal extremity) also presenting an heterotopic ossification at right scapulae (upper third of scapulae lateral margin and infraglenoid tubercule) and at the head of right humerus at the shoulder joint area. Curiously, this case also shows an unusual porosity in certain vertebrae´s body and in some tarsal and carpal bones. Likewise, his left fifth metacarpal bones (right and left) showed a healed fracture which led both bones distorted. Based on identification, of pathological conditions in human skeletal remains literature and protocols these alterations can be misdiagnosed and this skeleton may present more than one pathological process. The anthropological forensic lab at Medico-legal Institute Nina Rodrigues in Salvador (Brazil) adopts international protocols to ancestry, sex, age and stature estimations, also implemented well-established conventions to identify pathological disease and skeletal alterations. The most compatible diagnosis for this case is hematogenous osteomyelitis due to following findings: 1: the healed fracture pattern at the clavicle showing a cloaca which is a pathognomonic for osteomyelitis; 2: the metacarpals healed fracture does not present cloaca although they developed a periosteal formation. 3: the superior articular surface of the right tibia shows an extensive inflammatory healing process that extends to adjacent femur articular surface showing some cloaca at tibia bone disease. 4: the uncommon porosities may result from hematogenous infectious process. The fractures probably have occurred in a different moments based on the healing process; the tibia injury is more extensive and has not been reorganized, while metacarpals and clavicle fracture is properly healed. We suggest that the clavicle and tibia´s fractures were infected by an existing infectious disease (syphilis, tuberculosis, brucellosis) or an existing syndrome (Gorham’s disease), which led to the development of osteomyelitis. This hypothesis is supported by the fact that different bones are affected in diverse levels. Like the metacarpals that do not show the cloaca, but then a periosteal new bone formation; then the unusual porosities do not show a classical osteoarthritic processes findings as the marginal osteophyte, pitting and new bone formation, they just show an erosive process without bone formation or osteophyte. To confirm and prove our hypothesis we are working on different clinical approaches like DNA, histopathology and other image exams to find the correct diagnostic. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bone%20disease" title="bone disease">bone disease</a>, <a href="https://publications.waset.org/abstracts/search?q=forensic%20anthropology" title=" forensic anthropology"> forensic anthropology</a>, <a href="https://publications.waset.org/abstracts/search?q=hematogenous%20osteomyelitis" title=" hematogenous osteomyelitis"> hematogenous osteomyelitis</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20identification" title=" human identification"> human identification</a>, <a href="https://publications.waset.org/abstracts/search?q=human%20remains" title=" human remains"> human remains</a> </p> <a 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