Pharma - Flow Cytometry | NeoGenomics Laboratories

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block block-views block-views-blockgroup-header-block-1" id="block-views-block-group-header-block-1"> <div><div class="view view-group-header view-id-group_header view-display-id-block_1 js-view-dom-id-6634672d141e76f68107f9e07c1c6200352b7e8c4485c72fd6fc2accf34de0dd"> <div class="view-content"> <div class="views-row"><div class="views-field views-field-field-media-image-3-1"><div class="field-content"><div class="node-header"> <div class="node-header-image" data-node-header-image="/sites/default/files/hero-image/pharma-default-header-bg-img.jpg"> <div class="node-header-tab"></div> </div> <div class="node-header-content"> <div class="node-header-wrap"> <h1 class="page-title">Flow Cytometry</h1> <span class="blue-bar bar-large"></span> <div class="page-subtitle"></div> </div> </div> </div></div></div></div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockdefault-header-block-1" id="block-views-block-default-header-block-1"> <div><div 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id="main-content" tabindex="-1"></a> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-neogenomics-content" class="block block-system block-system-main-block"> <article data-history-node-id="1078" class="node node--type-page node--view-mode-full"> <div class="node__content"> <div class="field field--name-field-section field--type-entity-reference-revisions field--label-hidden field__items"> <div class="paragraph paragraph--type--columns paragraph--view-mode--default corporate-pattern-bg"> <div id="" class="col-half padding-top-bottom-50"> <div class="field field--name-field-column-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--wysiwyg paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><p class="large">Rely on our flow cytometry expertise and capabilities to deliver on your project.</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--wysiwyg paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><p>Our scientific and medical teams are experienced in flow cytometry assessments supporting many applications including hematopoietic neoplasms, MRD, receptor occupancy, expansive immunophenotyping, and Immuno-oncology assessments. NeoGenomics also offers other supporting services, such as global PBMC processing for retrospective or functional testing.  Harmonized processes and procedures are used across all global labs for continuity and consistency through longitudinal, global clinical trials.</p> </div> </div> </div> </div> </div> </div> <div id="" class="paragraph paragraph--type--wysiwyg-full-width paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><article class="align-center media media--type-image media--view-mode-default"> <div class="field--name-field-media-image"> <img class="lazyload-img" data-lazyload="/sites/default/files/2021-08/Flow%20image%20for%20website%20v2.jpg" src="/sites/default/files/styles/lazy_load/public/2021-08/Flow%20image%20for%20website%20v2.jpg?itok=5Kc_7DTp" alt="Flow Cytometry" height="493" width="1126"> </div> </article> </div> </div> <div id="" class="paragraph paragraph--type--icon-grid paragraph--view-mode--default corporate-pattern-bg items-per-row-2"> <div class="icon-grid-header"> <div class="field field--name-field-title field--type-string field--label-hidden field__item">Comprehensive and Customizable Offerings</div> </div> <div class="field field--name-field-icon-grid field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--icon-grid-item paragraph--view-mode--default"> <div class="field field--name-field-media field--type-entity-reference field--label-hidden field__item"><article class="media media--type-icon media--view-mode-default"> <div class="field field--name-field-media-image-2 field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/large/public/icons/Globe_Pharma_Purple_RGB.png?itok=hzzf74Y4" width="480" height="480" alt="Global reach" class="image-style-large" /> </div> </article> </div> <div class="field field--name-field-title field--type-string field--label-hidden field__item">Global Capabilities</div> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><p>Global, with all sites CAP accredited<br> Harmonized instrument calibration and specific reagent qualification for consistent assay performance globally<br> Robust and controlled assay transfers with data reproducibility at all global testing locations</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--icon-grid-item paragraph--view-mode--default"> <div class="field field--name-field-media field--type-entity-reference field--label-hidden field__item"><article class="media media--type-icon media--view-mode-default"> <div class="field field--name-field-media-image-2 field--type-image field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/large/public/icons/Regulated%20Seq_Pharma_Purple_RGB.png?itok=aHT9UKSX" width="480" height="480" alt="Regulated Seq Pharma icon" class="image-style-large" /> </div> </article> </div> <div class="field field--name-field-title field--type-string field--label-hidden field__item">Custom assay development and validation</div> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><p>Collaborative and consultative approach<br> Dedicated pathology review (if required)<br> Harmonized SOPs</p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--columns paragraph--view-mode--default"> <div id="" class="col-full padding-top-100"> <div class="field field--name-field-column-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--wysiwyg paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><h2 class="text-align-center">Flow Assay Design</h2> <p class="text-align-center">Intended Use</p> </div> </div> </div> </div> </div> </div> <div id="" class="paragraph paragraph--type--cards paragraph--view-mode--default"> <div class="cards-section"> <div class="cards-content"> <div class="content-wrap"> <div class="field field--name-field-cards field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--card paragraph--view-mode--default"> <div class="field field--name-field-title field--type-string field--label-hidden field__item">Primary/secondary endpoint & safety with full pathology review (LDT)</div> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><p>MRD status<br> Malignant cell characterization<br> CAR-T detection with custom anti-CAR-T antibody<br> TBNK enumeration</p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--card paragraph--view-mode--default"> <div class="field field--name-field-title field--type-string field--label-hidden field__item">Exploratory (fit for purpose)</div> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><p>Immunophenotyping (subsets, MD SC/dendritic, activation/exhaustion, rare event, etc.)<br> Receptor occupancy<br> Signal transduction/cell signaling<br> Intracellular cytokine/cell function<br> Checkpoint molecules<br> Apoptosis</p> </div> </div> </div> </div> </div> <div id="paragraph-id-579" class="media-wrap lazyload-bg" style="background-image: url('/sites/default/files/styles/lazy_load/public/2021-07/Flow_cards.png?itok=-PgQtVWp');" data-lazyload="/sites/default/files/2021-07/Flow_cards.png"></div> </div> </div> </div> <div class="paragraph paragraph--type--columns paragraph--view-mode--default corporate-pattern-bg"> <div id="" class="col-full padding-top-100"> <div class="field field--name-field-column-content field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--wysiwyg paragraph--view-mode--default"> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><h2>Example Assays and Reports</h2> </div> </div> </div> </div> </div> </div> <div id="" class="paragraph paragraph--type--accordion paragraph--view-mode--default"> <div class="field field--name-field-accordion-items field--type-entity-reference-revisions field--label-hidden field__items"> <div class="field__item"> <div class="paragraph paragraph--type--accordion-item paragraph--view-mode--default"> <div class="field field--name-field-title field--type-string field--label-hidden field__item">Examples of LDT assays and reports</div> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><h3>Multiple Myeloma MRD LTD Flow Assay</h3> <div class="inner-cols"> <div class="col"> <h4>Assay development requirements</h4> <ul> <li>Access MM patient bone marrow</li> <li>0.001% sensitivity</li> </ul> </div> <div class="col"> <h4>Assay parameters</h4> <ul> <li>3-5 million events collected</li> <li>10 markers</li> <li>Single tube assay (10 colors)</li> </ul> </div> </div> <article class="align-center media media--type-image media--view-mode-default"> <div class="field--name-field-media-image"> <img class="lazyload-img" data-lazyload="/sites/default/files/2021-09/MM%20MRD%20Assay%20v2.PNG" src="/sites/default/files/styles/lazy_load/public/2021-09/MM%20MRD%20Assay%20v2.PNG?itok=nazoyzoi" alt="MM MRD Assay" height="474" width="1050"> </div> </article> <h3>Example Results</h3> <p> </p> <h4>Diagnosis</h4> <p><strong>Clonal plasma cells are identified:</strong> <br>%MRD of total nucleated cells: 0.002% <br>MRD count: 70</p> <p><strong>Percentages from CD38+ and CD138+ gate (70 events)</strong> <br>CD56: 45 events, 64.29% <br>CD117: 2 events, 2.86% <br>CD81: 12 events, 17.14% <br>CD27: 4 events, 5. 71 % <br>CD19: 13 events, 18.57% <br>Non Clonal: 2 events, 2.86%</p> <p><strong>Markers Performed:</strong> <br>CD19, CD27, CD38, CD45, CD56, CD81, CD117, CD138, ckappa, cLambda (10 Markers)</p> <ul> <li>Output includes Diagnosis & Interpretation</li> <li>Pathologist Review & Signoff</li> <li>Reported to clinical site investigator for potential patient treatment decisions in addition to sponsor</li> </ul> <p> </p> </div> </div> </div> <div class="field__item"> <div class="paragraph paragraph--type--accordion-item paragraph--view-mode--default"> <div class="field field--name-field-title field--type-string field--label-hidden field__item">Examples of Exploratory assays and reports</div> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><h3>T-Cell Profiling Exploratory Flow Assay</h3> <article class="align-center media media--type-image media--view-mode-default"> <div class="field--name-field-media-image"> <img class="lazyload-img" data-lazyload="/sites/default/files/2021-09/T-Cell%20Profiling%20Exploratory%20Flow%20Assay%20v2.PNG" src="/sites/default/files/styles/lazy_load/public/2021-09/T-Cell%20Profiling%20Exploratory%20Flow%20Assay%20v2.PNG?itok=n7j3nuvS" alt="T-Cell profiling exploratory flow assay" height="604" width="1343"> </div> </article> <p> </p> <h3>Example Results</h3> <article class="align-center media media--type-image media--view-mode-default"> <div class="field--name-field-media-image"> <img class="lazyload-img" data-lazyload="/sites/default/files/2021-09/T-Cell%20profiling%20assay.PNG" src="/sites/default/files/styles/lazy_load/public/2021-09/T-Cell%20profiling%20assay.PNG?itok=lA0hZek4" alt="T-Cell assay results" height="393" width="1225"> </div> </article> <ul> <li>Output are data points / raw data</li> <li>No pathology review required</li> <li>Data is reported to sponsor or third party</li> <li>Results are RUO and no patient treatment decisions can be made</li> <li>Custom assays can be developed in house or transferred from client/partner laboratory</li> </ul> <p> </p> </div> </div> </div> </div> </div> <div class="paragraph paragraph--type--resources paragraph--view-mode--default"> <h4 class="resources-title">Resources</h4> <div class="field field--name-field-links field--type-link field--label-hidden field__items"> <div class="field__item"> <a href="/sites/default/files/2023-11/NeoG_Pharma_Flow-Cytometry_Brochure_111523_Final_Digital.pdf" tabindex="0" target="_blank"> Flow Cytometry Brochure </a> </div> <div class="field__item"> <a href="/sites/default/files/2021-07/Flow-Cytometry-Minimal-Residual-Disease.pdf" tabindex="0" target="_blank"> MRD Brochure </a> </div> <div class="field__item"> <a href="/sites/default/files/2021-11/Pharma_Minimal-MRD-Testing_Whitepaper_111021_Final.pdf" tabindex="0" target="_blank"> MRD White Paper </a> </div> <div class="field__item"> <a href="/sites/default/files/2021-07/Flow-Cytometry-Assessments-In-Clinical-Trials-A-Providers-Perspective.pdf" tabindex="0" target="_blank"> Clinical Trials White Paper </a> </div> <div class="field__item"> <a href="/events/webinars/development-implementation-flow-cytometry-assay-use-clinical-trials" tabindex="0" > Flow Cytometry On-demand Webinar </a> </div> </div> </div> <div class="paragraph paragraph--type--block-reference paragraph--view-mode--default"> <div class="field field--name-field-block-reference field--type-block-field field--label-hidden field__item"><div id="block-genericcontactcta" class="block block-block-content block-block-content8a55c531-c994-47e1-876c-0677143882c7 block--full-width-cta"> <div class="cta-content-wrap"> <div class="cta-content"> <h4 class="field--name-field-title">Contact Us 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