When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews

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content="INDEX,NOFOLLOW,NOARCHIVE"> <meta name="citation_journal_title" content="BMC Women's Health"> <meta name="citation_title" content="When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews"> <meta name="citation_author" content="Yue Zhou"> <meta name="citation_author_institution" content="College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China"> <meta name="citation_author" content="Xinyi Wang"> <meta name="citation_author_institution" content="College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China"> <meta name="citation_author" content="Yang Li"> <meta name="citation_author_institution" content="College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China"> <meta name="citation_author" content="Weiru Zhang"> <meta name="citation_author_institution" content="College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China"> <meta name="citation_author" content="Xiaoxuan Xu"> <meta name="citation_author_institution" content="College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China"> <meta name="citation_author" content="Yingxin Pang"> <meta name="citation_author_institution" content="College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China"> <meta name="citation_author" content="Peishu Liu"> <meta name="citation_author_institution" content="College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China"> <meta name="citation_author_institution" content="Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China"> <meta name="citation_publication_date" content="2024 Jun 28"> <meta name="citation_volume" content="24"> <meta name="citation_firstpage" content="375"> <meta name="citation_doi" content="10.1186/s12905-024-03184-y"> <meta name="citation_pmid" content="38937781"> <meta name="citation_abstract_html_url" content="https://pmc.ncbi.nlm.nih.gov/articles/PMC11212150/"> <meta 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Synchronous mucinous metaplasia and neoplasia of ..."> <meta name="og:title" content="When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews"> <meta name="og:type" content="article"> <meta name="og:site_name" content="PubMed Central (PMC)"> <meta name="og:description" content="Peutz-Jeghers syndrome (PJS) is characterized by the presence of hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation on the lips, oral mucosa, nose, fingers, and toes. 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role="menuitem">Search in PMC</a></li> <li role="presentation"><a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22BMC%20Womens%20Health%22%5Bjour%5D" lang="en" class="usa-link" role="menuitem">Search in PubMed</a></li> <li role="presentation"><a href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22BMC%20Womens%20Health%22%5BTitle%20Abbreviation%5D" class="usa-link" role="menuitem">View in NLM Catalog</a></li> <li role="presentation"><a href="?term=%22BMC%20Womens%20Health%22%5Bjour%5D" class="usa-link" role="menuitem" data-add-to-search="true">Add to search</a></li> </ul></nav></section><section class="front-matter"><div class="ameta p font-secondary font-xs"> <hgroup><h1>When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews</h1></hgroup><div class="cg p"> <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhou%20Y%22%5BAuthor%5D" class="usa-link" aria-describedby="id1"><span class="name western">Yue Zhou</span></a><div hidden="hidden" id="id1"> <h3><span class="name western">Yue Zhou</span></h3> <div class="p"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhou%20Y%22%5BAuthor%5D" class="usa-link"><span class="name western">Yue Zhou</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang%20X%22%5BAuthor%5D" class="usa-link" aria-describedby="id2"><span class="name western">Xinyi Wang</span></a><div hidden="hidden" id="id2"> <h3><span class="name western">Xinyi Wang</span></h3> <div class="p"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Wang%20X%22%5BAuthor%5D" class="usa-link"><span class="name western">Xinyi Wang</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Li%20Y%22%5BAuthor%5D" class="usa-link" aria-describedby="id3"><span class="name western">Yang Li</span></a><div hidden="hidden" id="id3"> <h3><span class="name western">Yang Li</span></h3> <div class="p"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Li%20Y%22%5BAuthor%5D" class="usa-link"><span class="name western">Yang Li</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhang%20W%22%5BAuthor%5D" class="usa-link" aria-describedby="id4"><span class="name western">Weiru Zhang</span></a><div hidden="hidden" id="id4"> <h3><span class="name western">Weiru Zhang</span></h3> <div class="p"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhang%20W%22%5BAuthor%5D" class="usa-link"><span class="name western">Weiru Zhang</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Xu%20X%22%5BAuthor%5D" class="usa-link" aria-describedby="id5"><span class="name western">Xiaoxuan Xu</span></a><div hidden="hidden" id="id5"> <h3><span class="name western">Xiaoxuan Xu</span></h3> <div class="p"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Xu%20X%22%5BAuthor%5D" class="usa-link"><span class="name western">Xiaoxuan Xu</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>3</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pang%20Y%22%5BAuthor%5D" class="usa-link" aria-describedby="id6"><span class="name western">Yingxin Pang</span></a><div hidden="hidden" id="id6"> <h3><span class="name western">Yingxin Pang</span></h3> <div class="p"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Pang%20Y%22%5BAuthor%5D" class="usa-link"><span class="name western">Yingxin Pang</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>3,</sup><sup>✉</sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Liu%20P%22%5BAuthor%5D" class="usa-link" aria-describedby="id7"><span class="name western">Peishu Liu</span></a><div hidden="hidden" id="id7"> <h3><span class="name western">Peishu Liu</span></h3> <div class="p"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div class="p"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="p">Find articles by <a href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Liu%20P%22%5BAuthor%5D" class="usa-link"><span class="name western">Peishu Liu</span></a> </div> </div> <sup>1,</sup><sup>2,</sup><sup>3,</sup><sup>✉</sup> </div> <ul class="d-buttons inline-list"> <li><button class="d-button" aria-controls="aip_a" aria-expanded="false">Author information</button></li> <li><button class="d-button" aria-controls="anp_a" aria-expanded="false">Article notes</button></li> <li><button class="d-button" aria-controls="clp_a" aria-expanded="false">Copyright and License information</button></li> </ul> <div class="d-panels font-secondary-light"> <div id="aip_a" class="d-panel p" style="display: none"> <div class="p" id="Aff1"> <sup>1</sup>College of Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div id="Aff2"> <sup>2</sup>Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, 107 Wenhua Xi Road, Jinan, Shandong People’s Republic of China </div> <div id="Aff3"> <sup>3</sup>Shandong Engineering Laboratory for Urogynecology, Qilu Hospital of Shandong University, Jinan, Shandong People’s Republic of China </div> <div class="author-notes p"><div class="fn" id="_fncrsp93pmc__"> <sup>✉</sup><p class="display-inline">Corresponding author.</p> </div></div> </div> <div id="anp_a" class="d-panel p" style="display: none"><div class="notes p"><section id="historyarticle-meta1" class="history"><p>Received 2024 Feb 2; Accepted 2024 Jun 5; Collection date 2024.</p></section></div></div> <div id="clp_a" class="d-panel p" style="display: none"> <div>© The Author(s) 2024</div> <p><strong>Open Access</strong> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit <a href="https://creativecommons.org/licenses/by/4.0/" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">http://creativecommons.org/licenses/by/4.0/</a>. The Creative Commons Public Domain Dedication waiver (<a href="https://creativecommons.org/publicdomain/zero/1.0/" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">http://creativecommons.org/publicdomain/zero/1.0/</a>) applies to the data made available in this article, unless otherwise stated in a credit line to the data.</p> <div class="p"><a href="/about/copyright/" class="usa-link">PMC Copyright notice</a></div> </div> </div> <div>PMCID: PMC11212150 PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/38937781/" class="usa-link">38937781</a> </div> </div></section></section><section aria-label="Article content"><section class="body main-article-body"><section class="abstract" id="Abs1"><h2>Abstract</h2> <section id="sec1"><h3 class="pmc_sec_title">Background</h3> <p id="Par1">Peutz-Jeghers syndrome (PJS) is characterized by the presence of hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation on the lips, oral mucosa, nose, fingers, and toes. Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) refers to the occurrence of multifocal mucinous lesions in at least two sites, including the cervix, uterus, fallopian tubes, and ovaries, in the female genital tract. SMMN-FGT and PJS are rare diseases with a very low incidence, especially when occurring simultaneously.</p></section><section id="sec2"><h3 class="pmc_sec_title">Case presentation</h3> <p id="Par2">We report a case in which a woman with a large mass on the left ovary underwent a gynecological surgery and was diagnosed with cervical gastric-type adenocarcinoma and mucinous lesions in the endometrium, bilateral fallopian tubes, and ovary, i.e., SMMN-FGT, by postoperative paraffin pathology. The patient sought medical attention for abdominal distension and enlargement. A gynecological ultrasound revealed a multilocular cystic mass in the pelvis, while serum tumor markers were within normal limits, with mildly elevated carbohydrate antigen 199 and carbohydrate antigen 125 levels. Cervical thin-prep cytology test result was negative. The patient had a family history of PJS with black spots on her skin and mucous membranes since the age of 8 years. She underwent multiple partial small bowel resections and gastrointestinal polypectomy owing to intestinal obstruction and intussusception. She underwent left adnexectomy, hysterectomy, right salpingectomy, greater omental resection, appendectomy and right ovary biopsy, and received six courses of adjuvant chemotherapy with Lopressor plus Carboplatin. Genetic testing revealed a heterozygous serine threonine kinase 11 germline mutation and there were no signs of recurrence during the 18-month follow-up period after treatment.</p></section><section id="sec3"><h3 class="pmc_sec_title">Conclusions</h3> <p id="Par3">This is a rare case in which PJS was complicated by SMMN-FGT. Owing to its extreme rarity, there are no guidelines, but reported cases appear to indicate a poor prognosis. We retrospectively reviewed all cases of collisions between PJS and SMMN-FGT and explored the clinical features, pathological characteristics, diagnosis, treatment methods, and prognosis when the two diseases coexisted. The aim is to deepen the clinicians’ understanding of this disease for early detection, diagnosis and treatment.</p></section><section id="sec4"><h3 class="pmc_sec_title">Supplementary Information</h3> <p>The online version contains supplementary material available at 10.1186/s12905-024-03184-y.</p></section><section id="kwd-group1" lang="en" class="kwd-group"><p><strong>Keywords:</strong> Peutz-Jeghers syndrome, Adenocarcinoma, STK11, Mucinous metaplasia and neoplasia, Female genital tract</p></section></section><section id="Sec1"><h2 class="pmc_sec_title">Background</h2> <p id="Par5">Peutz-Jeghers syndrome (PJS) was first reported by Peutz in 1921 and later by Jeghers et al. with a prevalence of approximately 1/50,000-200,000 [<a href="#CR1" class="usa-link" aria-describedby="CR1">1</a>].It is characterized by hamartomatous polyps in the gastrointestinal tract and mucocutaneous pigmentation on the lips, oral mucosa, nose, fingers, and toes. Evidence suggests that patients with PJS have an increased risk of developing cancer, including gastrointestinal and extraintestinal cancers [<a href="#CR2" class="usa-link" aria-describedby="CR2">2</a>]. Female patients with PJS tend to have mucinous lesions in their genital organs, ranging from cystic or hyperplastic benign lesions to borderline neoplasms and to malignant tumors. Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT) [<a href="#CR3" class="usa-link" aria-describedby="CR3">3</a>] refers to the occurrence of multifocal mucinous lesions in at least two sites in the female genital tract. It is a rare disease, and the diagnostic standards, treatment options, and follow-up criteria have not yet been standardized. Low morbidity, lack of specific symptoms, and challenges in preoperative diagnosis can lead to frequent clinical misdiagnosis or missed diagnosis, resulting in delayed treatment. Patients with PJS have a higher lifetime risk of cancer, whereas those with SMMN-FGT have a poor prognosis. SMMN-FGT and PJS are both rare diseases with very low incidence, especially they occur simultaneously. However, the symptoms of PJS may provide evidence of SMMN-FGT. Herein, we report a case of a woman with a long history of PJS who was diagnosed with SMMN-FGT in our hospital. We also reviewed all reported cases in which the two diseases coexisted to alert clinicians to the importance of early detection, diagnosis, and treatment of malignant tumors in these patients. Additionally, we stress the importance of cancer risk surveillance in individuals with PJS.</p></section><section id="Sec2"><h2 class="pmc_sec_title">Case presentation</h2> <p id="Par6">A 38-year-old woman visited our hospital on 24 October 2022 for “abdominal distension and gradual enlargement of the lower abdomen for more than 3 months” and was diagnosed with SMMN-FGT after gynecological surgery. Gynecological examinations and ancillary tests revealed no specific changes. Uterine body palpation was unsatisfactory, and a large cystic mass reaching the umbilicus was palpable in the adnexal area. The cervix was smooth, with a small amount of transparent fluid flowing out. Ultrasound at our hospital revealed a multilocular cystic mass in the pelvis with multiple dense partitions inside. Blood flow signals were found above the partitions, and the cyst was hypoechoic and filled with fine and dense spots. The cervical thin-prep cytology test (TCT) was negative, and serum tumor markers were normal with carbohydrate antigen 199 (CA199) and carbohydrate antigen 125 (CA125) mildly elevated. No other abnormal radiological or laboratory results were observed. In summary, the possible diagnosis of the female patient was an ovarian tumor.</p> <p id="Par7">Considering the possibility of a malignant tumor, the patient underwent laparoscopic exploration and subsequent laparotomy on 28 October 2022 and was finally diagnosed with cervical gastric-type adenocarcinoma. During laparoscopic exploration, a large amount of yellowish viscous fluid and a large mass on the left ovary with a diameter of 20 cm were observed, while the uterus, right ovary and other organs were normal to the naked eye. Therefore, left adnexectomy and right ovary biopsy were performed firstly. Intraoperative frozen section pathology revealed borderline mucinous tumors in the left ovary and cortical stromal hyperplasia in the right ovary. Hysterectomy, right salpingectomy, greater omental resection, and appendectomy were performed subsequently. Postoperative pathology showed gastric-type adenocarcinoma of the cervix, with a lesion involving approximately 80% of the entire uterine wall and a depth of approximately 10 mm, proliferation of mucinous glands in the endometrium, borderline mucinous cystic tumor of the left adnexa, mucinous gland metaplasia, and mild atypical proliferation of the right fallopian tube (Fig. <a href="#Fig1" class="usa-link">1</a>). There was proliferation of mucinous glands in the cervix, endometrium, bilateral fallopian tubes, and left ovary, with some glandular dysplasia and tumor formation, suggesting concurrent mucinous metaplasia and tumors, i.e., SMMN-FGT.</p> <figure class="fig xbox font-sm" id="Fig1"><h3 class="obj_head">Fig. 1.</h3> <p class="img-box line-height-none margin-x-neg-2 tablet:margin-x-0 text-center"><a class="tileshop" target="_blank" href="https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=11212150_12905_2024_3184_Fig1_HTML.jpg"><img class="graphic zoom-in" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/688b/11212150/e3eaac619284/12905_2024_3184_Fig1_HTML.jpg" loading="lazy" id="d33e265" height="663" width="762" alt="Fig. 1"></a></p> <div class="p text-right font-secondary"><a href="figure/Fig1/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div> <figcaption><p>Pathology findings after surgery (H-E stain), (<strong>A</strong>) gastric-type adenocarcinoma of cervical (×100), (<strong>B</strong>) cervical lobular mucinous gland hyperplasia (×100), (<strong>C</strong>) proliferation of mucinous glands in endometrium (×100), (<strong>D</strong>) mucinous gland metaplasia and mild atypia proliferation of right fallopian tube (×100), (<strong>E</strong>)mucinous cystic tumor of left ovary (×100)</p></figcaption></figure><p id="Par9">Because of the young age and benign result of the right ovary biopsy, supplemental surgery was not conducted, and postoperative adjuvant chemotherapy was administered instead. On 15 November 2022 the patient underwent the first course of chemotherapy with a regimen of Paclitaxel Liposome for Injection plus Carboplatin. Six courses of chemotherapy were administered with the last course on 17 April 2023, and no signs of recurrence were observed during the 18-month follow-up period after surgery.</p> <p id="Par10">It is worth noting that this patient had black spots on her skin and mucous membranes since the age of 8 years, mainly distributed on the face, lips, fingers, and toes; these spots partially diminished after she gave birth to her daughter in 2008. In 2001, she underwent a partial small bowel resection owing to “intestinal obstruction” at a local hospital and was diagnosed with PJS based on postoperative pathology. She underwent multiple surgeries to remove the gastrointestinal polyps and a part of the small intestine owing to recurrence. Genetic testing revealed a heterozygous type serine threonine kinase 11 (STK11) germline mutation. The patient’s father died of liver cancer associated with PJS. Her mother is healthy, while her younger brother had a history of PJS and has undergone several surgeries So far, no extraintestinal cancers have been found. Her daughter is currently 15 years old and has not exhibited any black spots or other symptoms.</p></section><section id="Sec3"><h2 class="pmc_sec_title">Discussion and conclusions</h2> <p id="Par11">SMMN-FGT combined with PJS is extremely rare, with only 11 cases reported [<a href="#CR4" class="usa-link" aria-describedby="CR4">4</a>–<a href="#CR13" class="usa-link" aria-describedby="CR13">13</a>] to our knowledge (Table 1). The patients were aged between 30 and 54 years, with one aged 75 years. Its clinical presentation is non-specific, with most patients complaining of pelvic masses, abnormal vaginal bleeding, increased vaginal discharge, or abdominal discomfort. The patient in this study was 38 years old, presented with abdominal distension and was diagnosed with a pelvic mass on imaging. However, upon reviewing the patient’s medical history, it was found that she had experienced thin, transparent vaginal discharge for more than a year, which she believed to be normal vaginal secretions and did not pay much attention to. Finally, the possibility of cervical tumors was overlooked because of the negative result of cervical TCT result. Auxiliary examinations, including imaging studies and serum tumor markers, show no obvious specificity, and ultrasonography often suggests polycystic lesions in the affected areas. Tumor markers are usually normal, however, when accompanied by gastric-type adenocarcinoma, an increase in CA199 is common, while CA125 is often normal or slightly elevated.</p> <section class="tw xbox font-sm" id="Tab1"><h3 class="obj_head">Table 1.</h3> <div class="caption p"><p>Reported cases of co-occurrence of SMMN-FGT and PJS</p></div> <div class="tbl-box p" tabindex="0"><table class="content" frame="hsides" rules="groups"> <thead><tr> <th align="left" colspan="1" rowspan="1">Case No.</th> <th align="left" colspan="1" rowspan="1">Age<br>(y)</th> <th align="left" colspan="1" rowspan="1">STK11</th> <th align="left" colspan="1" rowspan="1">Presentation</th> <th align="left" colspan="1" rowspan="1">Pathology</th> <th align="left" colspan="1" rowspan="1">Primary surgery</th> <th align="left" colspan="1" rowspan="1">Adjuvant therapy</th> <th align="left" colspan="1" rowspan="1">Metastasis /Recurrence</th> <th align="left" colspan="1" rowspan="1">Follow-up</th> <th align="left" colspan="1" rowspan="1">Author</th> <th align="left" colspan="1" rowspan="1">Date</th> </tr></thead> <tbody> <tr> <td align="left" colspan="1" rowspan="1">1</td> <td align="left" colspan="1" rowspan="1">36</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">abdominal pain</td> <td align="left" colspan="1" rowspan="1">intestinal-like metaplasia of fallopian tube epithelium, SCTAT of ovary, metastasizing adenocarcinoma of cervix</td> <td align="left" colspan="1" rowspan="1">radical hysterectomy and BSO</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1"> <p>metastasis,</p> <p>3 years</p> </td> <td align="left" colspan="1" rowspan="1">DOD, 19mo after metastasis</td> <td align="left" colspan="1" rowspan="1">COSTA J [<a href="#CR4" class="usa-link" aria-describedby="CR4">4</a>]</td> <td align="left" colspan="1" rowspan="1">1976</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">2</td> <td align="left" colspan="1" rowspan="1">54</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">SCTAT of ovary, MDA of cervix, metaplasia of fallopian tubes</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">BERGER G [<a href="#CR5" class="usa-link" aria-describedby="CR5">5</a>]</td> <td align="left" colspan="1" rowspan="1">1981</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">3</td> <td align="left" colspan="1" rowspan="1">33</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">menometrorrhagia and an adnexal mass</td> <td align="left" colspan="1" rowspan="1">SCTAT, OMC, MDA of cervix, metaplasia of fallopian tubes</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and RSO</td> <td align="left" colspan="1" rowspan="1">CT</td> <td align="left" colspan="1" rowspan="1"> <p>recurrence,</p> <p>2 mo</p> </td> <td align="left" colspan="1" rowspan="1">DOD, 7 mo after recurrence</td> <td align="left" colspan="1" rowspan="1">Chen [<a href="#CR6" class="usa-link" aria-describedby="CR6">6</a>]</td> <td align="left" colspan="1" rowspan="1">1986</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">4</td> <td align="left" colspan="1" rowspan="1">40</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">pelvic mass</td> <td align="left" colspan="1" rowspan="1">SCTAT of ovary, cervical adenoma malignum</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and BSO</td> <td align="left" colspan="1" rowspan="1"> <p>CT,</p> <p>RT after metastasis</p> </td> <td align="left" colspan="1" rowspan="1"> <p>metastasis,</p> <p>5 years</p> </td> <td align="left" colspan="1" rowspan="1">DOD, 4 mo after metastasis</td> <td align="left" colspan="1" rowspan="1">Podezaski E [<a href="#CR7" class="usa-link" aria-describedby="CR7">7</a>]</td> <td align="left" colspan="1" rowspan="1">1991</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">5</td> <td align="left" colspan="1" rowspan="1">42</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">persistent leukorrhea</td> <td align="left" colspan="1" rowspan="1">invasive mucinous carcinoma of cervix, SCTAT of ovary, focal adenocarcinoma of endometrium</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and BSO</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1"> <p>dead of unknown reason,</p> <p>54 mo</p> </td> <td align="left" colspan="1" rowspan="1">SEIDMAN JD [<a href="#CR8" class="usa-link" aria-describedby="CR8">8</a>]</td> <td align="left" colspan="1" rowspan="1">1994</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">6</td> <td align="left" colspan="1" rowspan="1">42</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">abdominal pain, left adnexal mass</td> <td align="left" colspan="1" rowspan="1">MDA of cervix, mucosal metaplasia of fallopian tubes, borderline malignancy of R ovary</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and LSO, bilateral sampling of external iliac lymph nodes and ileal resection <sup>a</sup> </td> <td align="left" colspan="1" rowspan="1">No</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1"> <p>NED,</p> <p>21 mo</p> </td> <td align="left" colspan="1" rowspan="1">MANGILI G [<a href="#CR9" class="usa-link" aria-describedby="CR9">9</a>]</td> <td align="left" colspan="1" rowspan="1">2004</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">7</td> <td align="left" colspan="1" rowspan="1">53</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">pyloric gland metaplasia and differentiation of uterine cervix, fallopian tubes and ovary</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and BSO</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">Kato N [<a href="#CR10" class="usa-link" aria-describedby="CR10">10</a>]</td> <td align="left" colspan="1" rowspan="1">2011</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">8</td> <td align="left" colspan="1" rowspan="1">30</td> <td align="left" colspan="1" rowspan="1">Yes</td> <td align="left" colspan="1" rowspan="1">fallopian tube mass</td> <td align="left" colspan="1" rowspan="1">mucinous hyperplasia of fallopian tube and ovary</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1"> <p>recurrence,</p> <p>3 mo</p> </td> <td align="left" colspan="1" rowspan="1"> <p>DOD,</p> <p>43 mo</p> </td> <td align="left" colspan="1" rowspan="1">Bennett JA [<a href="#CR11" class="usa-link" aria-describedby="CR11">11</a>]</td> <td align="left" colspan="1" rowspan="1">2021</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">9</td> <td align="left" colspan="1" rowspan="1">33</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">abnormal vaginal bleeding</td> <td align="left" colspan="1" rowspan="1">LEGH of cervix, multifocal gastric-type MCM of endometrium and fallopian tubes</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and BS</td> <td align="left" colspan="1" rowspan="1">No</td> <td align="left" colspan="1" rowspan="1">No</td> <td align="left" colspan="1" rowspan="1"> <p>NED,</p> <p>43mo</p> </td> <td align="left" colspan="1" rowspan="1"> <p>Chen</p> <p> [<a href="#CR12" class="usa-link" aria-describedby="CR12">12</a>]</p> </td> <td align="left" colspan="1" rowspan="1">2022</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">10</td> <td align="left" colspan="1" rowspan="1">37</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">abnormal vaginal bleeding</td> <td align="left" colspan="1" rowspan="1">LEGH of cervix and endometrium</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and BS</td> <td align="left" colspan="1" rowspan="1">No</td> <td align="left" colspan="1" rowspan="1">No</td> <td align="left" colspan="1" rowspan="1"> <p>NED,</p> <p>29mo</p> </td> <td align="left" colspan="1" rowspan="1"> <p>Chen</p> <p> [<a href="#CR12" class="usa-link" aria-describedby="CR12">12</a>]</p> </td> <td align="left" colspan="1" rowspan="1">2022</td> </tr> <tr> <td align="left" colspan="1" rowspan="1">11</td> <td align="left" colspan="1" rowspan="1">75</td> <td align="left" colspan="1" rowspan="1">NA</td> <td align="left" colspan="1" rowspan="1">elevation of the CA199</td> <td align="left" colspan="1" rowspan="1">malignant transformation of R fallopian tube, mucinous hyperplasia of L fallopian tube and R ovary</td> <td align="left" colspan="1" rowspan="1">total hysterectomy and BSO</td> <td align="left" colspan="1" rowspan="1">CT</td> <td align="left" colspan="1" rowspan="1"> <p>metastasis,</p> <p>2 years</p> </td> <td align="left" colspan="1" rowspan="1"> <p>DOD,</p> <p>several mo</p> </td> <td align="left" colspan="1" rowspan="1">Bronte Anaut M [<a href="#CR13" class="usa-link" aria-describedby="CR13">13</a>]</td> <td align="left" colspan="1" rowspan="1">2023</td> </tr> </tbody> </table></div> <div class="p text-right font-secondary"><a href="table/Tab1/" class="usa-link" target="_blank" rel="noopener noreferrer">Open in a new tab</a></div> <div class="tw-foot p"><div class="fn" id="_fn_p43"><p><em>Abbreviation</em> R: right; L: left; DOD: dead of disease; NA: not available; NED: no evidence of disease; RT: radiotherapy; CT: chemotherapy; SCTAT: Sex cord tumor with annular tubules; MDA: minimal deviation adenocarcinoma; BSO: bilateral salpingo-oophorectomy; RSO: right salpingo-oophorectomy; LSO: left salpingo-oophorectomy; BS: bilateral salpingectomy; LEGH: lobular endocervical glandular hyperplasia; MCM: mucous cell metaplasia; OMC: ovarian mucinous cystadenoma. “<sup>a</sup>” indicates that the patient was underwent a right salpingo-oophorectomy because of a serous-papillary cystoadenoma 6 years ago</p></div></div></section><p id="Par14">Owing to the rarity of SMMN-FGT, there is currently no internationally recognized standard treatment. Most reported cases underwent total hysterectomy and bilateral salpingo-oophorectomy. Some studies [<a href="#CR14" class="usa-link" aria-describedby="CR14">14</a>] suggest that ovarian preservation may not be recommended for gastric-type adenocarcinoma patients and consider omentectomy as part of surgical treatment. Regarding adjuvant therapy, different physicians have varying opinions on whether and what kind of adjuvant therapy should be administered postoperatively. As shown in Table 1, some patients received adjuvant chemotherapy postoperatively, whereas others with benign lesions only underwent close follow-up without postoperative adjuvant therapy. Radiotherapy has been used in patients with metastasis. However, the role of adjuvant therapy could not be assessed because of lack of information. In our case, the patient underwent left adnexectomy, hysterectomy, right salpingo-oophorectomy, greater omental resection and appendectomy. In addition, the right ovary was preserved because intraoperative frozen pathology suggested that no tumor was detected in the right ovary. However, this may have been inadequately treated. Finally, the patient received six courses of postoperative adjuvant chemotherapy with Lipiodol plus Carboplatin. Diagnosis of SMMN-FGT relies on postoperative pathology with the presence of mucinous lesions in at least two sites in the female genital tract. Of the reported cases, nine involved the cervix; nine ovaries; eight fallopian tubes; and three endometrium, with pathological types ranging from mucous hyperplasia and metaplasia to carcinoma. In our case, mucinous lesions involved four sites in the reproductive tract: the cervix, endometrium, fallopian tubes, and left ovary.</p> <p id="Par15">The disease prognosis depends on the grade of the most severe lesion, with gastric-type adenocarcinoma having the worst prognosis [<a href="#CR15" class="usa-link" aria-describedby="CR15">15</a>]. Of the previously reported cases, two were lost to follow-up, three showed no signs of disease recurrence, and the remaining cases died of disease recurrence, metastasis, or other causes, with a follow-up time of no more than 5 years, suggesting a poor prognosis. Of the three surviving patients, two (case 9 and 10) had bilateral ovaries preserved owing to benign intraoperative pathology. These patients were young, and they were followed up without adjuvant treatment because of benign lesions. As for the last follow-up, conducted at 43 and 29 months, respectively, neither patient showed signs of recurrence. However, in view of the possibility of malignancy, close follow-up is recommended, and prophylactic resection of both ovaries should be considered after menopause. One malignant case was followed up for 21 months without signs of recurrence, which may have been related to extensive surgery (case 6, with partial resection of the bowel). The patient in our case is currently being followed up for 18 months, with no signs of recurrence. This may be attributed to postoperative adjuvant chemotherapy; however, as one ovary was preserved, close follow-up is required.</p> <p id="Par16">The pathogenesis of SMMN-FGT is unknown, and the histological changes are closely related to pyloric gland metaplasia and exhibits a series of morphological features ranging from metaplasia to invasive mucinous adenocarcinoma with a complex mechanism. Morphological features of SMMN-FGT include simple gastric-type mucinous metaplasia, papillary growth, atypical papillary growth, microinvasive adenocarcinoma, gastric-type adenocarcinoma, mucinous metaplasia of the fallopian tube, ovarian mucinous cystadenoma, and borderline or mucinous ovarian carcinoma. Therefore, we hypothesize that SMMN-FGT is a group of diseases consisting of benign lesions that progressively become malignant over time.</p> <p id="Par17">PJS is an autosomal dominant disorder caused by mutations in the liver kinase B1 (LKB1) gene, also known as STK11 gene, which functions as a tumor suppressor gene and is located on chromosome 19p13.3 [<a href="#CR16" class="usa-link" aria-describedby="CR16">16</a>]. Mutations in this gene can dysregulate various signaling pathways such as mTOR, Wnt/β-catenin, or TCF-4, leading to the development of PJS, but the exact mechanism remains unclear. SMMN-FGT may be associated with genes related to the PJS, such as STK11. Jennifer reported [<a href="#CR11" class="usa-link" aria-describedby="CR11">11</a>] 22 examples of novel adnexal tumors associated with PJS in nearly 50% of the cases that harbored STK11 alterations. In published cases, the STK11 altered status remains unknown owing to age and technical limitations, but the presence of the STK11 mutation was confirmed in our case, which suggests that SMMN-FGT is associated with the STK11 mutation. However, the histogenesis of SMMN-FGT remains unclear, and further studies, especially transcriptomic, epigenetic, and proteomic analyses, are warranted.</p> <p id="Par18">Patients with PJS have a higher risk of developing malignant tumors, therefore, early detection and regular monitoring of high-risk patients are crucial. No clear guidelines currently exist for the surveillance of high-risk cancers of the female genital tract secondary to the PJS. However, relevant study [<a href="#CR17" class="usa-link" aria-describedby="CR17">17</a>] have indicated that transvaginal ultrasound, serum CA125 test, pelvic examination and cervical smear should be performed annually, beginning at 18 years of age. Simultaneously, attention should be paid to menstruation and leucorrhea. In case of persistent abnormal uterine bleeding or vaginal discharge, even if the cervical TCT is negative, a biopsy should be performed, if necessary, for early diagnosis. In addition, owing to its rare onset and challenging diagnosis, gynecologists, gastroenterologists, dermatologists, urologists, and pathologists need to be more vigilant in their clinical practice.</p> <p id="Par19">Patient education, including, regular follow-ups, genetic counseling, early screening, and predictive diagnosis of their direct relatives, is particularly important. Patients should be informed of the high susceptibility of PJS to cancer and urged to follow-up regularly as prescribed by their doctor, note any symptoms of discomfort, and seek medical attention in a timely manner. Completion of genetic testing is recommended to guide follow-up and treatment and to provide a basis for monitoring the disease in relatives. Considering the genetic predisposition, early screening and predictive diagnosis of direct relatives are crucial. It is recommended that the patient’s 15-year-old daughter undergo regular medical examinations early on. The American College of Gastroenterology recommends regularly monitoring of patients with PJS from a young age, with upper gastrointestinal and small bowel series examinations starting at the age of 8 years and colonoscopy every 3 years thereafter [<a href="#CR18" class="usa-link" aria-describedby="CR18">18</a>]. Regular pelvic imaging should be performed in adulthood, with attention to menstrual status and abnormal vaginal discharge. The appearance of mucocutaneous pigmentation should be closely monitored, and, genetic testing should be performed to clarify the presence of STK11 mutations.</p> <p id="Par20">In conclusion, SMMN-FGT refers to multifocal mucinous lesions occurring simultaneously in the female genital tract. Its onset is rare, especially when complicated with PJS. The occurrence of SMMN-FGT may be associated with mutations in STK11, a gene associated with PJS. The clinical presentation is nonspecific, and diagnosis relies on pathological examination, which is often a diagnostic challenge for pathologists because of the extensive nature of the lesions. Surgical resection is the treatment of choice; however, the efficacy of postoperative adjuvant therapy is unknown with poor prognosis. Therefore, the early detection and regular medical surveillance of high-risk patients are crucial. Patients with PJS are advised to undergo regular medical check-ups for early detection of other malignancies, and their immediate family members must be screened regularly. Gynecologists should consider the possibility of SMMN-FGT when observing female patients with PJS and strive for early detection, diagnosis, and treatment. Gastroenterologists, dermatologists and urologists should be more alert to the symptoms of PJS in their clinical work.</p></section><section id="Sec4"><h2 class="pmc_sec_title">Electronic supplementary material</h2> <p>Below is the link to the electronic supplementary material.</p> <section class="sm xbox font-sm" id="MOESM1"><div class="media p"><div class="caption"> <a href="/articles/instance/11212150/bin/12905_2024_3184_MOESM1_ESM.pdf" data-ga-action="click_feat_suppl" class="usa-link">Supplementary Material 1</a><sup> (680.6KB, pdf) </sup> </div></div></section></section><section id="ack1" class="ack"><h2 class="pmc_sec_title">Acknowledgements</h2> <p>We would like to thank Editage (<a href="http://www.editage.cn" class="usa-link usa-link--external" data-ga-action="click_feat_suppl" target="_blank" rel="noopener noreferrer">www.editage.cn</a>) for English language editing.</p></section><section id="glossary1" class="glossary"><h2 class="pmc_sec_title">Abbreviations</h2> <dl class="def-list"> <dt>PJS</dt> <dd><p id="Par24">Peutz-Jeghers syndrome</p></dd> <dt>SMMN-FGT</dt> <dd><p id="Par25">Synchronous mucinous metaplasia and neoplasia of the female genital tract</p></dd> <dt>CA125</dt> <dd><p id="Par26">Carbohydrate antigen 125</p></dd> <dt>CA199</dt> <dd><p id="Par27">Carbohydrate antigen 199</p></dd> <dt>STK11</dt> <dd><p id="Par28">Serine threonine kinase 11</p></dd> <dt>LKB1</dt> <dd><p id="Par29">Liver kinase B1</p></dd> <dt>TCT</dt> <dd><p id="Par30">Thin-prep cytology test</p></dd> </dl></section><section id="notes1"><h2 class="pmc_sec_title">Author contributions</h2> <p>Y.Z. collected the information and wrote the main manuscript text, X.Y.W. and Y.L. communicated with the patient and got the signed consent, W.R.Z. and X.X.X. edited the manuscript, Y.X.P. prepared Fig. 1, P.S.L. developed the project, edited and revised the manuscript.All authors reviewed the manuscript.</p></section><section id="notes2"><h2 class="pmc_sec_title">Funding</h2> <p>This work was supported by Natural Science Foundation of Shandong Province ZR2020QH044 and ZR2020MH272.</p></section><section id="notes3"><h2 class="pmc_sec_title">Data availability</h2> <p>Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.</p></section><section id="notes4"><h2 class="pmc_sec_title">Declarations</h2> <section id="FPar1"><h3 class="pmc_sec_title">Ethics approval and consent to participate</h3> <p id="Par21">This study was approved by the ethics committee of Qilu hospital, Shandong University with an ethical approval number of KYLL-202308-015.</p></section><section id="FPar2"><h3 class="pmc_sec_title">Consent for publication</h3> <p id="Par22">This study has obtained written informed consent to the publish from the patient.</p></section><section id="FPar3"><h3 class="pmc_sec_title">Competing interests</h3> <p id="Par23">The authors declare no competing interests.</p></section></section><section id="fn-group1" class="fn-group"><h2 class="pmc_sec_title">Footnotes</h2> <div class="fn-group p font-secondary-light font-sm"><div class="fn p" id="fn1"> <p><strong>Publisher’s Note</strong></p> <p>Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.</p> </div></div></section><section id="_ci93_" lang="en" class="contrib-info"><h2 class="pmc_sec_title">Contributor Information</h2> <p>Yingxin Pang, Email: yingxinpang@126.com.</p> <p>Peishu Liu, Email: peishuliu@126.com.</p></section><section id="Bib1" class="ref-list"><h2 class="pmc_sec_title">References</h2> <section id="Bib1_sec2"><ul class="ref-list font-sm" style="list-style-type:none"> <li id="CR1"> <span class="label">1.</span><cite>Jeghers H, Mc KV, Katz KH. 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class="associated-data"><h2 class="pmc_sec_title">Associated Data</h2> <p class="font-secondary"><em>This section collects any data citations, data availability statements, or supplementary materials included in this article.</em></p> <section id="_adsm93_" lang="en" class="supplementary-materials"><h3 class="pmc_sec_title">Supplementary Materials</h3> <section class="sm xbox font-sm" id="db_ds_supplementary-material1_reqid_"><div class="media p"><div class="caption"> <a href="/articles/instance/11212150/bin/12905_2024_3184_MOESM1_ESM.pdf" data-ga-action="click_feat_suppl" class="usa-link">Supplementary Material 1</a><sup> (680.6KB, pdf) </sup> </div></div></section></section><section id="_adda93_" lang="en" class="data-availability-statement"><h3 class="pmc_sec_title">Data Availability Statement</h3> <p>Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.</p></section></section></section><footer class="p courtesy-note 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When synchronous mucinous metaplasia and neoplasia of the female genital tract and peutz-jeghers syndrome meet: a case report and literature reviews - PMC