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class="m-2">/</span></span><span class="text-bmj-silver-600 text-sm font-normal not-italic leading-4" data-testid="top cited articles">Top Cited Articles</span></div></div><a href="https://myaccount.bmj.com/myaccount/signup.html?regService=etoc-alerts&corpusCode=gutjnl&fwdUrl=https://gut.bmj.com/" class="decoration-none text-bmj-blue-500 [&:hover]:text-bmj-primary-brand hidden md:inline-block"><div class="flex"><div class="mr-2 flex"><svg class="text-bmj-primary-brand h-4 w-8" data-testid="envelope-icon" viewBox="0 0 33 22" fill="none" xmlns="http://www.w3.org/2000/svg"><path d="M1 1H32V21H1V1Z" fill="white" stroke="currentColor"></path><path d="M31.9 20.8L21 9" stroke="currentColor"></path><path d="M1 20.5L11.8 9" stroke="currentColor"></path><mask id="path-4-inside-1" fill="white"><path d="M0.600098 0.700012L16.6001 13.4L32.4001 0.900012"></path></mask><path d="M16.6001 13.4L15.9784 14.1833L16.5991 14.6759L17.2205 14.1843L16.6001 13.4ZM-0.0216079 1.48326L15.9784 14.1833L17.2218 12.6168L1.2218 -0.0832389L-0.0216079 1.48326ZM17.2205 14.1843L33.0205 1.68426L31.7797 0.115765L15.9796 12.6158L17.2205 14.1843Z" fill="currentColor" mask="url(#path-4-inside-1)"></path></svg></div><span class="text-base leading-4" data-testid="email-alerts-link">Email alerts</span></div></a></div><main><div><section class="whitespace-pre-wrap pb-12 [&_p]:mb-4"><div><div class="m-0 mx-auto w-full min-w-0 max-w-[77rem] px-4"><h1 data-testid="sections-page-title" class="mb-5">Top Cited Articles</h1><div class="border-bmj-silver-100 border-1 m-0 ml-auto mr-auto w-full min-w-0 border-t border-b border-solid" data-testid="about-keymetrics-panel"><div class="md:flex-unset flex grid-cols-[repeat(auto-fill,11.25rem)] flex-col justify-between pt-4 pb-5 md:grid" data-testid="key-metrics-header"><div class="text-bmj-silver-800 flex flex-col justify-between pt-5 pr-0 md:pt-0 md:pr-4 [&>div:nth-of-type(1)]:mr-1 [&>div:nth-of-type(1)]:text-base [&>div:nth-of-type(2)]:text-2xl pb-5" data-testid="1066"><div>Acceptance rate:</div><div>12%</div></div><div class="text-bmj-silver-800 flex flex-col justify-between pt-5 pr-0 md:pt-0 md:pr-4 [&>div:nth-of-type(1)]:mr-1 [&>div:nth-of-type(1)]:text-base [&>div:nth-of-type(2)]:text-2xl pb-5" data-testid="1067"><div>Time to first decision with review:</div><div>23 days*</div></div><div class="text-bmj-silver-800 flex flex-col justify-between pt-5 pr-0 md:pt-0 md:pr-4 [&>div:nth-of-type(1)]:mr-1 [&>div:nth-of-type(1)]:text-base [&>div:nth-of-type(2)]:text-2xl pb-5" data-testid="1068"><div>Impact Factor (JCR):</div><div>23.1</div></div><div class="text-bmj-silver-800 flex flex-col justify-between pt-5 pr-0 md:pt-0 md:pr-4 [&>div:nth-of-type(1)]:mr-1 [&>div:nth-of-type(1)]:text-base [&>div:nth-of-type(2)]:text-2xl pb-5" data-testid="1069"><div>Impact Factor rank (JCR):</div><div>5/143</div></div><div class="text-bmj-silver-800 flex flex-col justify-between pt-5 pr-0 md:pt-0 md:pr-4 [&>div:nth-of-type(1)]:mr-1 [&>div:nth-of-type(1)]:text-base [&>div:nth-of-type(2)]:text-2xl pb-5" data-testid="1070"><div>Citescore:</div><div>45.7</div></div><div class="text-bmj-silver-800 flex flex-col justify-between pt-5 pr-0 md:pt-0 md:pr-4 [&>div:nth-of-type(1)]:mr-1 [&>div:nth-of-type(1)]:text-base [&>div:nth-of-type(2)]:text-2xl pb-5" data-testid="1071"><div>Total Altmetric mentions:</div><div>6,947</div></div></div><div class="mb-4 flex flex-col md:flex-row" data-testid="key-metrics-footer"><div class="mr-0 mb-6 md:mr-20 md:mb-0"><a data-testid="1073" href="/pages/about/#journal_statistics">More journal metrics</a></div><div class="mr-0 mb-6 md:mr-20 md:mb-0"><a data-testid="1074" href="https://www.bmj.com/company/researchimpactmetrics">How we get these metrics</a></div><div data-testid="median-number-of-days">*median number of days</div></div></div><div class="border-t-[1px] border-solid border-transparent" data-testid="sections-container-0"><div class=" text-bmj-silver-800 whitespace-pre-wrap font-normal leading-[1.625rem] mt-0 flex flex-col md:mt-4 md:flex-row [&>div:last-of-type]:pr-0 [&>div]:mt-6 [&>div]:pr-0 [&>div]:md:mt-0 [&>div]:md:pr-4 [&>div:nth-of-type(1)]:w-full [&>div:nth-of-type(1)]:md:w-[50.00%] [&>div:nth-of-type(2)]:w-full [&>div:nth-of-type(2)]:md:w-[50.00%] " data-testid="sections-subsection-content-container-0"><div data-testid="sections-column-0" class="inline md:inline [&_h2]:mt-0"><a href="/content/71/5/1020">Gut microbiome and health: mechanistic insights</a> <a href="/content/72/2/338.long">Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN</a> <a href="/content/71/9/1724">Management of <em>Helicobacter pylori </em>infection: the Maastricht VI/Florence consensus report</a> <a href="/content/71/3/544">Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome</a> <a href="/content/71/11/2233">Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation</a> <a href="/content/71/4/734">Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy</a> <a href="/content/71/5/1006">Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis</a> <a href="/content/71/2/309">Gut microbiota modulates COPD pathogenesis: role of anti-inflammatory <i>Parabacteroides goldsteinii</i> lipopolysaccharide</a> <a href="/content/71/12/2439">Cigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites</a> <a href="/content/72/9/1774">Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade</a></div><div data-testid="sections-column-1" class="inline md:inline [&_h2]:mt-0"><a href="/content/71/7/1359">A faecal microbiota signature with high specificity for pancreatic cancer</a> <a href="/content/71/6/1053">Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis</a> <a href="/content/71/3/521"><em>Lactobacillus rhamnosus</em> GG induces cGAS/STING-dependent type I interferon and improves response to immune checkpoint blockade</a> <a href="/content/71/10/2011"><i>Lactobacillus gallinarum</i> modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis</a> <a href="/content/71/10/e1.3">Inflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism</a> <a href="/content/71/7/1412">Cancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes</a> <a href="/content/72/1/180">Advancing human gut microbiota research by considering gut transit time</a> <a href="/content/72/5/958">Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment</a> <a href="/content/71/12/2539">FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2</a> <a href="/content/72/10/1848">A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut</a></div></div></div></div></div></section></div></main></div></div><footer><div class="border-bmj-silver-100 border-t-solid m-0 ml-auto mr-auto flex w-full min-w-0 flex-wrap gap-4 border border-b-0 border-l-0 border-r-0 pl-4 pr-4"><a class="my-4" href="https://www.bsg.org.uk/" data-testid="association-logo-1-link" aria-label="BSG-SOCIETY-LOGO"><img data-testid="association-logo-1" title="BSG-SOCIETY-LOGO" 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href=\"https://gut.bmj.com/content/71/5/1020\"\u003eGut microbiome and health: mechanistic insights\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/72/2/338.long\"\u003eGlobal burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/9/1724\"\u003eManagement of \u003cem\u003eHelicobacter pylori \u003c/em\u003einfection: the Maastricht VI/Florence consensus report\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/3/544\"\u003eGut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/11/2233\"\u003eGut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/4/734\"\u003eGinseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/5/1006\"\u003eDiagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/2/309\"\u003eGut microbiota modulates COPD pathogenesis: role of anti-inflammatory \u003ci\u003eParabacteroides goldsteinii\u003c/i\u003e lipopolysaccharide\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/12/2439\"\u003eCigarette smoke promotes colorectal cancer through modulation of gut microbiota and related metabolites\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/72/9/1774\"\u003eCombining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade\u003c/a\u003e","\u003ca href=\"https://gut.bmj.com/content/71/7/1359\"\u003eA faecal microbiota signature with high specificity for pancreatic cancer\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/6/1053\"\u003eMultitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/3/521\"\u003e\u003cem\u003eLactobacillus rhamnosus\u003c/em\u003e GG induces cGAS/STING-dependent type I interferon and improves response to immune checkpoint blockade\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/10/2011\"\u003e\u003ci\u003eLactobacillus gallinarum\u003c/i\u003e modulates the gut microbiota and produces anti-cancer metabolites to protect against colorectal tumourigenesis\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/10/e1.3\"\u003eInflammatory cell-derived CXCL3 promotes pancreatic cancer metastasis through a novel myofibroblast-hijacked cancer escape mechanism\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/7/1412\"\u003eCancer pharmacomicrobiomics: targeting microbiota to optimise cancer therapy outcomes\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/72/1/180\"\u003eAdvancing human gut microbiota research by considering gut transit time\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/72/5/958\"\u003eSingle-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/71/12/2539\"\u003eFSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2\u003c/a\u003e\r\n\r\n\u003ca href=\"https://gut.bmj.com/content/72/10/1848\"\u003eA mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut\u003c/a\u003e"],"layoutType":"B"}]}],"seoMetadata":[{"key":"title","property":"title","content":"Top Cited Articles | Gut"},{"key":"robots","property":"robots","content":"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1"},{"key":"canonical","property":"canonical","content":"https://gut.bmj.com/pages/top-cited-articles"},{"key":"og_locale","property":"og:locale","content":"en_US"},{"key":"og_type","property":"og:type","content":"article"},{"key":"og_title","property":"og:title","content":"Top Cited Articles | Gut"},{"key":"og_description","property":"og:description","content":"The most highly cited articles published in Gut between 2021 and 2022 are made free to read."},{"key":"description","name":"description","content":"The most highly cited articles published in Gut between 2021 and 2022 are 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