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class="vector-toc-link" href="#Mixed"> <div class="vector-toc-text"> 5.2 Mixed </div> </a> <ul id="toc-Mixed-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Antagonists" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Antagonists"> <div class="vector-toc-text"> 5.3 Antagonists </div> </a> <ul id="toc-Antagonists-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-As_a_drug_target" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#As_a_drug_target"> <div class="vector-toc-text"> 6 As a drug target </div> </a> <button aria-controls="toc-As_a_drug_target-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> Toggle As a drug target subsection </button> <ul id="toc-As_a_drug_target-sublist" class="vector-toc-list"> <li id="toc-Drug_resistance" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Drug_resistance"> <div class="vector-toc-text"> 6.1 Drug resistance </div> </a> <ul id="toc-Drug_resistance-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> 7 Interactions </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> 8 See also </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> 9 References </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1"> <a class="vector-toc-link" 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Available in 21 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-21" aria-hidden="true" > 21 languages </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%B3%D8%AA%D9%82%D8%A8%D9%84%D8%A7%D8%AA_%D8%A7%D9%84%D8%A3%D9%86%D8%AF%D8%B1%D9%88%D8%AC%D9%8A%D9%86" title="مستقبلات الأندروجين – Arabic" lang="ar" hreflang="ar" data-title="مستقبلات الأندروجين" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target">العربية</a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Androgeni_receptor" title="Androgeni receptor – Bosnian" lang="bs" hreflang="bs" data-title="Androgeni receptor" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target">Bosanski</a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Receptor_androg%C3%A8nic" title="Receptor androgènic – Catalan" lang="ca" hreflang="ca" data-title="Receptor androgènic" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target">Català</a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Androgenrezeptor" title="Androgenrezeptor – German" lang="de" hreflang="de" data-title="Androgenrezeptor" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target">Deutsch</a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Receptor_androg%C3%A9nico" title="Receptor androgénico – Spanish" lang="es" hreflang="es" data-title="Receptor androgénico" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target">Español</a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%AF%DB%8C%D8%B1%D9%86%D8%AF%D9%87_%D8%A2%D9%86%D8%AF%D8%B1%D9%88%DA%98%D9%86" title="گیرنده آندروژن – Persian" lang="fa" hreflang="fa" data-title="گیرنده آندروژن" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target">فارسی</a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/R%C3%A9cepteur_des_androg%C3%A8nes" title="Récepteur des androgènes – French" lang="fr" hreflang="fr" data-title="Récepteur des androgènes" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target">Français</a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Receptor_de_andr%C3%B3xenos" title="Receptor de andróxenos – Galician" lang="gl" hreflang="gl" data-title="Receptor de andróxenos" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target">Galego</a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%95%88%EB%93%9C%EB%A1%9C%EA%B2%90_%EC%88%98%EC%9A%A9%EC%B2%B4" title="안드로겐 수용체 – Korean" lang="ko" hreflang="ko" data-title="안드로겐 수용체" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target">한국어</a></li><li class="interlanguage-link interwiki-ka mw-list-item"><a href="https://ka.wikipedia.org/wiki/%E1%83%90%E1%83%9C%E1%83%93%E1%83%A0%E1%83%9D%E1%83%92%E1%83%94%E1%83%9C%E1%83%98%E1%83%A1_%E1%83%A0%E1%83%94%E1%83%AA%E1%83%94%E1%83%9E%E1%83%A2%E1%83%9D%E1%83%A0%E1%83%98" title="ანდროგენის რეცეპტორი – Georgian" lang="ka" hreflang="ka" data-title="ანდროგენის რეცეპტორი" data-language-autonym="ქართული" data-language-local-name="Georgian" class="interlanguage-link-target">ქართული</a></li><li class="interlanguage-link interwiki-la mw-list-item"><a href="https://la.wikipedia.org/wiki/Receptorium_androgeni" title="Receptorium androgeni – Latin" lang="la" hreflang="la" data-title="Receptorium androgeni" data-language-autonym="Latina" data-language-local-name="Latin" class="interlanguage-link-target">Latina</a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A2%E3%83%B3%E3%83%89%E3%83%AD%E3%82%B2%E3%83%B3%E5%8F%97%E5%AE%B9%E4%BD%93" title="アンドロゲン受容体 – Japanese" lang="ja" hreflang="ja" data-title="アンドロゲン受容体" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target">日本語</a></li><li class="interlanguage-link interwiki-ru badge-Q17437798 badge-goodarticle mw-list-item" title="good article badge"><a href="https://ru.wikipedia.org/wiki/%D0%90%D0%BD%D0%B4%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%BE%D0%B2%D1%8B%D0%B9_%D1%80%D0%B5%D1%86%D0%B5%D0%BF%D1%82%D0%BE%D1%80" title="Андрогеновый рецептор – Russian" lang="ru" hreflang="ru" data-title="Андрогеновый рецептор" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target">Русский</a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%D9%88%DB%95%D8%B1%DA%AF%D8%B1%DB%8C_%D8%A6%DB%95%D9%86%D8%AF%D8%B1%DB%86%D8%AC%DB%8C%D9%86" title="وەرگری ئەندرۆجین – Central Kurdish" lang="ckb" hreflang="ckb" data-title="وەرگری ئەندرۆجین" data-language-autonym="کوردی" data-language-local-name="Central Kurdish" class="interlanguage-link-target">کوردی</a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%90%D0%BD%D0%B4%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%B8_%D1%80%D0%B5%D1%86%D0%B5%D0%BF%D1%82%D0%BE%D1%80" title="Андрогени рецептор – Serbian" lang="sr" hreflang="sr" data-title="Андрогени рецептор" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target">Српски / srpski</a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Androgeenireseptori" title="Androgeenireseptori – Finnish" lang="fi" hreflang="fi" data-title="Androgeenireseptori" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target">Suomi</a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Androgenreceptor" title="Androgenreceptor – Swedish" lang="sv" hreflang="sv" data-title="Androgenreceptor" data-language-autonym="Svenska" data-language-local-name="Swedish" class="interlanguage-link-target">Svenska</a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Androjen_resept%C3%B6r%C3%BC" title="Androjen reseptörü – Turkish" lang="tr" hreflang="tr" data-title="Androjen reseptörü" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target">Türkçe</a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D0%BD%D0%B4%D1%80%D0%BE%D0%B3%D0%B5%D0%BD%D0%BD%D0%B8%D0%B9_%D1%80%D0%B5%D1%86%D0%B5%D0%BF%D1%82%D0%BE%D1%80" title="Андрогенний рецептор – Ukrainian" lang="uk" hreflang="uk" data-title="Андрогенний рецептор" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target">Українська</a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Th%E1%BB%A5_th%E1%BB%83_androgen" title="Thụ thể androgen – Vietnamese" lang="vi" hreflang="vi" data-title="Thụ thể androgen" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target">Tiếng Việt</a></li><li 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searchaux" style="display:none">Mammalian protein found in humans</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">AR</th></tr><tr><td colspan="4" style="text-align:center"><a href="/wiki/File:2AM9.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/4/40/2AM9.png/250px-2AM9.png" decoding="async" width="250" height="207" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/40/2AM9.png/375px-2AM9.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/40/2AM9.png/500px-2AM9.png 2x" data-file-width="929" data-file-height="768" /></a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P19091%20or%20P10275%20or%20Q9NUA2">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P19091,P10275,Q9NUA2">RCSB</a> </td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1E3G">1E3G</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1GS4">1GS4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1T5Z">1T5Z</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1T63">1T63</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1T65">1T65</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1XJ7">1XJ7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1XOW">1XOW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1XQ3">1XQ3</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1Z95">1Z95</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AM9">2AM9</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AMA">2AMA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AMB">2AMB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AO6">2AO6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AX6">2AX6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AX7">2AX7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AX8">2AX8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AX9">2AX9</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2AXA">2AXA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2HVC">2HVC</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2OZ7">2OZ7</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIO">2PIO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIP">2PIP</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIQ">2PIQ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIR">2PIR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIT">2PIT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIU">2PIU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIV">2PIV</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIW">2PIW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PIX">2PIX</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PKL">2PKL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2PNU">2PNU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2Q7I">2Q7I</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2Q7J">2Q7J</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2Q7K">2Q7K</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2YHD">2YHD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2YLO">2YLO</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2YLP">2YLP</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2YLQ">2YLQ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2Z4J">2Z4J</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3B5R">3B5R</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3B65">3B65</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3B66">3B66</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3B67">3B67</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3B68">3B68</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3BTR">3BTR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3V49">3V49</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3V4A">3V4A</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3ZQT">3ZQT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4HLW">4HLW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3L3X">3L3X</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3L3Z">3L3Z</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3RLJ">3RLJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3RLL">3RLL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4K7A">4K7A</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OEA">4OEA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OED">4OED</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OEY">4OEY</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OEZ">4OEZ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OFR">4OFR</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OFU">4OFU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OGH">4OGH</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OH5">4OH5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OH6">4OH6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OHA">4OHA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OIL">4OIL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OIU">4OIU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OJ9">4OJ9</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OJB">4OJB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OK1">4OK1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OKB">4OKB</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OKT">4OKT</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OKW">4OKW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OKX">4OKX</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4OLM">4OLM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4QL8">4QL8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5CJ6">5CJ6</a></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/644">AR</a>, AIS, AR8, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM, androgen receptor</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/313700">313700</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:88064">88064</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=28">28</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=AR">AR</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000169083">AR - orthologs</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/File:Ideogram_human_chromosome_X.svg" class="mw-file-description" title="X chromosome (human)"><img alt="X chromosome (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/300px-Ideogram_human_chromosome_X.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/450px-Ideogram_human_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/18/Ideogram_human_chromosome_X.svg/600px-Ideogram_human_chromosome_X.svg.png 2x" data-file-width="474" data-file-height="189" /></a></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/X_chromosome_(human)" class="mw-redirect" title="X chromosome (human)">X chromosome (human)</a><a href="#cite_note-refGRCh38Ensembl-1">[1]</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><a href="/wiki/File:Human_chromosome_X_ideogram.svg" class="mw-file-description" title="X chromosome (human)"><img alt="X chromosome (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/300px-Human_chromosome_X_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/450px-Human_chromosome_X_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/Human_chromosome_X_ideogram.svg/600px-Human_chromosome_X_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a><div style="position: absolute; left: 122.09466331261px; top: 2px; padding: 0;"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for AR"><img alt="Genomic location for AR" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></div><div style="position: absolute; left: 128.1px; top: 19px; padding: 0;"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for AR"><img alt="Genomic location for AR" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Xq12</td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit">67,544,021 <a href="/wiki/Base_pair" title="Base pair">bp</a><a href="#cite_note-refGRCh38Ensembl-1">[1]</a></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit">67,730,619 <a href="/wiki/Base_pair" title="Base pair">bp</a><a href="#cite_note-refGRCh38Ensembl-1">[1]</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/File:Ideogram_house_mouse_chromosome_X.svg" class="mw-file-description" title="X chromosome (mouse)"><img alt="X chromosome (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/260px-Ideogram_house_mouse_chromosome_X.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/390px-Ideogram_house_mouse_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/59/Ideogram_house_mouse_chromosome_X.svg/520px-Ideogram_house_mouse_chromosome_X.svg.png 2x" data-file-width="470" data-file-height="200" /></a></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">X chromosome (mouse)<a href="#cite_note-refGRCm38Ensembl-2">[2]</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_X.svg" class="mw-file-description" title="X chromosome (mouse)"><img alt="X chromosome (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/300px-Ideogram_of_house_mouse_chromosome_X.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/450px-Ideogram_of_house_mouse_chromosome_X.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/da/Ideogram_of_house_mouse_chromosome_X.svg/600px-Ideogram_of_house_mouse_chromosome_X.svg.png 2x" data-file-width="1200" data-file-height="231" /></a><div style="position: absolute; left: 161.89779649544px; top: 2px; padding: 0;"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for AR"><img alt="Genomic location for AR" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></div><div style="position: absolute; left: 167.9px; top: 19px; padding: 0;"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for AR"><img alt="Genomic location for AR" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">X C3|X 42.82 cM</td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit">97,192,375 <a href="/wiki/Base_pair" title="Base pair">bp</a><a href="#cite_note-refGRCm38Ensembl-2">[2]</a></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit">97,366,821 <a href="/wiki/Base_pair" title="Base pair">bp</a><a href="#cite_note-refGRCm38Ensembl-2">[2]</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><a href="/wiki/Human_genome" title="Human genome">Human</a></th><th><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000169083">Top expressed in</a></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">seminal vesicula</li> <li style="line-height: 137%;">urethra</li> <li style="line-height: 137%;">nipple</li> <li style="line-height: 137%;">vulva</li> <li style="line-height: 137%;">corpus epididymis</li> <li style="line-height: 137%;">human penis</li> <li style="line-height: 137%;">caput epididymis</li> <li style="line-height: 137%;">tail of epididymis</li> <li style="line-height: 137%;">lactiferous duct</li> <li style="line-height: 137%;">liver</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000046532">Top expressed in</a></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">lacrimal gland</li> <li style="line-height: 137%;">ventromedial nucleus</li> <li style="line-height: 137%;">seminal vesicula</li> <li style="line-height: 137%;">efferent ductule</li> <li style="line-height: 137%;">cumulus cell</li> <li style="line-height: 137%;">lobe of prostate</li> <li style="line-height: 137%;">anterior amygdaloid area</li> <li style="line-height: 137%;">lateral hypothalamus</li> <li style="line-height: 137%;">triceps brachii muscle</li> <li style="line-height: 137%;">vas deferens</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000169083">More reference expression data</a></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/File:PBB_GE_AR_211110_s_at.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/PBB_GE_AR_211110_s_at.png/250px-PBB_GE_AR_211110_s_at.png" decoding="async" width="250" height="132" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/a/a1/PBB_GE_AR_211110_s_at.png 1.5x" data-file-width="255" data-file-height="135" /></a> <a href="/wiki/File:PBB_GE_AR_211621_at.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/PBB_GE_AR_211621_at.png/250px-PBB_GE_AR_211621_at.png" decoding="async" width="250" height="132" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/3/38/PBB_GE_AR_211621_at.png 1.5x" data-file-width="255" data-file-height="135" /></a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/gene/367/">More reference expression data</a></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008289">lipid binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005102">signaling receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043565">sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000978">RNA polymerase II cis-regulatory region sequence-specific DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046983">protein dimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003682">chromatin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008270">zinc ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004879">nuclear receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051117">ATPase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005497">androgen binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005496">steroid binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001228">DNA-binding transcription activator activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008134">transcription factor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003677">DNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008013">beta-catenin binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070974">POU domain binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019899">enzyme binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003700">DNA-binding transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000981">DNA-binding transcription factor activity, RNA polymerase II-specific</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001091">RNA polymerase II general transcription initiation factor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003707">steroid hormone receptor activity</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016607">nuclear speck</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008285">negative regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045597">positive regulation of cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051092">positive regulation of NF-kappaB transcription factor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007548">sex differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045720">negative regulation of integrin biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007267">cell-cell signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030522">intracellular receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030850">prostate gland development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045726">positive regulation of integrin biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042327">positive regulation of phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030521">androgen receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010628">positive regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045893">positive regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2001237">negative regulation of extrinsic apoptotic signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006367">transcription initiation from RNA polymerase II promoter</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008283">cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016049">cell growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045945">positive regulation of transcription by RNA polymerase III</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051259">protein complex oligomerization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043568">positive regulation of insulin-like growth factor receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019102">male somatic sex determination</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033148">positive regulation of intracellular estrogen receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050680">negative regulation of epithelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010468">regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003073">regulation of systemic arterial blood pressure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048645">animal organ formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035264">multicellular organism growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043410">positive regulation of MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001701">in utero embryonic development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061458">reproductive system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060748">tertiary branching involved in mammary gland duct morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009987">cellular process or phenomenon</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008584">male gonad development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007338">single fertilization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009566">fertilization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060685">regulation of prostatic bud formation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060749">mammary gland alveolus development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060742">epithelial cell differentiation involved in prostate gland development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003382">epithelial cell morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006357">regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0072520">seminiferous tubule development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060571">morphogenesis of an epithelial fold</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060740">prostate gland epithelium morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033327">Leydig cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048608">reproductive structure development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050790">regulation of catalytic activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048638">regulation of developmental growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060599">lateral sprouting involved in mammary gland duct morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048808">male genitalia morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060736">prostate gland growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060520">activation of prostate induction by androgen receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007283">spermatogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016579">protein deubiquitination</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060769">positive regulation of epithelial cell proliferation involved in prostate gland development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000122">negative regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071383">cellular response to steroid hormone stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071394">cellular response to testosterone stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903076">regulation of protein localization to plasma membrane</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td>Human</td><td>Mouse</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=367&rn=1">367</a></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=11835&rn=1">11835</a></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000169083;db=core">ENSG00000169083</a></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000046532;db=core">ENSMUSG00000046532</a></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P10275">P10275</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9NUA2">Q9NUA2</a></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P19091">P19091</a></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001011645">NM_001011645</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000044">NM_000044</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001348061">NM_001348061</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001348063">NM_001348063</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001348064">NM_001348064</a></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_013476">NM_013476</a></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000035">NP_000035</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001011645">NP_001011645</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001334990">NP_001334990</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001334992">NP_001334992</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001334993">NP_001334993</a> </th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000035.2">NP_000035.2</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001011645.1">NP_001011645.1</a></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_038504">NP_038504</a></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chrX:67544021-67730619">Chr X: 67.54 – 67.73 Mb</a></td><td><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chrX:97192375-97366821">Chr X: 97.19 – 97.37 Mb</a></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><a href="#cite_note-3">[3]</a></td><td><a href="#cite_note-4">[4]</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14873015" class="extiw" title="d:Q14873015">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14873019" class="extiw" title="d:Q14873019">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein family</div> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above">Androgen_recep</th></tr><tr><td colspan="2" class="infobox-image"><a href="/wiki/File:PDB_1xow_EBI.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/6f/PDB_1xow_EBI.jpg/220px-PDB_1xow_EBI.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/6f/PDB_1xow_EBI.jpg/330px-PDB_1xow_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/6f/PDB_1xow_EBI.jpg/440px-PDB_1xow_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a><div class="infobox-caption">crystal structure of the human androgen receptor ligand binding domain bound with an androgen receptor nh2-terminal peptide, ar20-30, and r1881</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #ddd; color:inherit;">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit;">Symbol</th><td class="infobox-data" style="background-color: #eee; color:inherit;">Androgen_recep</td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit;"><a href="/wiki/Pfam" title="Pfam">Pfam</a></th><td class="infobox-data pfam" style="background-color: #eee; color:inherit;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/pfam/PF02166">PF02166</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit;"><a href="/wiki/InterPro" title="InterPro">InterPro</a></th><td class="infobox-data" style="background-color: #eee; color:inherit;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/interpro/entry/IPR001103">IPR001103</a></td></tr><tr><td colspan="2" class="infobox-full-data" style="background-color: #eee; color:inherit;"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1257001546" /><table class="infobox mw-collapsible mw-collapsed" style="float:none; clear:none; margin:0; border-width:0; border-collapse:collapse; text-align:left; width:100%"><tbody><tr><th colspan="2" class="infobox-header" style="background-color: #ddd; color:inherit;">Available protein structures:</th></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Pfam" title="Pfam">Pfam</a>  </th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="http://pfam.xfam.org/family/PF02166?tab=pdbBlock">structures</a> / <a rel="nofollow" class="external text" href="http://prodata.swmed.edu/ecod/complete/search?kw=PF02166">ECOD</a>  </td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_annotation.annotation_id:PF02166%20AND%20rcsb_polymer_entity_annotation.type:Pfam">RCSB PDB</a>; <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/entry/search/index?pfam_accession:PF02166">PDBe</a>; <a rel="nofollow" class="external text" href="https://pdbj.org/search/pdb?other_db_select=PFam&other_db_field=PF02166">PDBj</a></td></tr><tr><th scope="row" class="infobox-label" style="background-color: #e7dcc3; color:inherit; border:#fafafa 2px solid; border-width:3px 2px 0 0;"><a href="/wiki/PDBsum" title="PDBsum">PDBsum</a></th><td class="infobox-data" style="background-color: #eee; color:inherit; border:#fafafa 2px solid; border-width:3px 0 0 2px;"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPfamStr.pl?pfam_id=PF02166">structure summary</a></td></tr></tbody></table></td></tr></tbody></table> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Human_androgen_receptor_and_androgen_binding.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Human_androgen_receptor_and_androgen_binding.svg/294px-Human_androgen_receptor_and_androgen_binding.svg.png" decoding="async" width="294" height="210" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Human_androgen_receptor_and_androgen_binding.svg/441px-Human_androgen_receptor_and_androgen_binding.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Human_androgen_receptor_and_androgen_binding.svg/588px-Human_androgen_receptor_and_androgen_binding.svg.png 2x" data-file-width="653" data-file-height="467" /></a><figcaption>Normal function of the androgen receptor. Testosterone (T) enters the cell and, if 5-alpha-reductase is present, is converted into dihydrotestosterone (DHT). Upon steroid binding, the androgen receptor (AR) undergoes a conformational change and releases heat-shock proteins (hsps). Phosphorylation (P) occurs before or after steroid binding. The AR translocates to the nucleus where dimerization, DNA binding, and the recruitment of coactivators occur. Target genes are transcribed (mRNA) and translated into proteins.<a href="#cite_note-pmid7671849-5">[5]</a><a href="#cite_note-pmid15705293-6">[6]</a><a href="#cite_note-pmid9845666-7">[7]</a><a href="#cite_note-pmid12700055-8">[8]</a></figcaption></figure> The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">nuclear receptor</a><a href="#cite_note-pmid17132855-9">[9]</a> that is activated by binding any of the <a href="/wiki/Androgen" title="Androgen">androgenic</a> <a href="/wiki/Hormones" class="mw-redirect" title="Hormones">hormones</a>, including <a href="/wiki/Testosterone" title="Testosterone">testosterone</a> and <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a>,<a href="#cite_note-pmid9949684-10">[10]</a> in the <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasm</a> and then translocating into the <a href="/wiki/Cell_nucleus" title="Cell nucleus">nucleus</a>. The androgen receptor is most closely related to the <a href="/wiki/Progesterone_receptor" title="Progesterone receptor">progesterone receptor</a>, and <a href="/wiki/Progestin" class="mw-redirect" title="Progestin">progestins</a> in higher dosages can block the androgen receptor.<a href="#cite_note-pmid6371845-11">[11]</a><a href="#cite_note-pmid12600226-12">[12]</a> The main function of the androgen receptor is as a <a href="/wiki/DNA-binding_protein" title="DNA-binding protein">DNA-binding</a> <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a> that <a href="/wiki/Gene_expression_regulation" class="mw-redirect" title="Gene expression regulation">regulates gene expression</a>;<a href="#cite_note-pmid3549275-13">[13]</a> however, the androgen receptor has other functions as well.<a href="#cite_note-pmid12351684-14">[14]</a> Androgen-regulated genes are critical for the development and maintenance of the male sexual <a href="/wiki/Phenotype" title="Phenotype">phenotype</a>. <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=1" title="Edit section: Function">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Effect_on_development">Effect on development</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=2" title="Edit section: Effect on development">edit</a>]</div> In some cell types, testosterone interacts directly with androgen receptors, whereas, in others, testosterone is converted by <a href="/wiki/5-alpha_reductase" class="mw-redirect" title="5-alpha reductase">5-alpha-reductase</a> to dihydrotestosterone, an even more potent <a href="/wiki/Agonist" title="Agonist">agonist</a> for androgen receptor activation.<a href="#cite_note-pmid16633980-15">[15]</a> Testosterone appears to be the primary androgen receptor-activating hormone in the <a href="/wiki/Wolffian_duct" class="mw-redirect" title="Wolffian duct">Wolffian duct</a>, whereas dihydrotestosterone is the main androgenic hormone in the <a href="/wiki/Urogenital_sinus" title="Urogenital sinus">urogenital sinus</a>, <a href="/w/index.php?title=Urogenital_tubercle&action=edit&redlink=1" class="new" title="Urogenital tubercle (page does not exist)">urogenital tubercle</a>, and <a href="/wiki/Hair_follicle" title="Hair follicle">hair follicles</a>.<a href="#cite_note-pmid12834017-16">[16]</a> Testosterone is therefore responsible primarily for the development of male <a href="/wiki/Sex_organ" title="Sex organ">primary sexual characteristics</a>, whilst dihydrotestosterone is responsible for <a href="/wiki/Secondary_sex_characteristic" title="Secondary sex characteristic">secondary male characteristics</a>. Androgens cause slow maturation of the bones, but more of the potent maturation effect comes from the <a href="/wiki/Estrogen" title="Estrogen">estrogen</a> produced by <a href="/wiki/Aromatization" title="Aromatization">aromatization</a> of androgens. <a href="/wiki/Steroid" title="Steroid">Steroid</a> users of teen age may find that their growth had been stunted by androgen and/or estrogen excess. People with too little sex hormones can be short during puberty but end up taller as adults as in <a href="/wiki/Androgen_insensitivity_syndrome" title="Androgen insensitivity syndrome">androgen insensitivity syndrome</a> or <a href="/wiki/Estrogen_insensitivity_syndrome" title="Estrogen insensitivity syndrome">estrogen insensitivity syndrome</a>.<a href="#cite_note-pmid12868122-17">[17]</a> <a href="/wiki/Knockout-mice" class="mw-redirect" title="Knockout-mice">Knockout-mice</a> studies have shown that the androgen receptor is essential for normal female fertility, being required for development and full functionality of the <a href="/wiki/Ovarian_follicle" title="Ovarian follicle">ovarian follicles</a> and <a href="/wiki/Ovulation" title="Ovulation">ovulation</a>, working through both intra-ovarian and <a href="/wiki/Neuroendocrine" class="mw-redirect" title="Neuroendocrine">neuroendocrine</a> mechanisms.<a href="#cite_note-Walters_2010-18">[18]</a> <div class="mw-heading mw-heading3"><h3 id="Maintenance_of_male_skeletal_integrity">Maintenance of male skeletal integrity</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=3" title="Edit section: Maintenance of male skeletal integrity">edit</a>]</div> Via the androgen receptor, androgens play a key role in the maintenance of male skeletal integrity. The regulation of this integrity by androgen receptor (AR) signaling can be attributed to both <a href="/wiki/Osteoblast" title="Osteoblast">osteoblasts</a> and <a href="/wiki/Osteocyte" title="Osteocyte">osteocytes</a>.<a href="#cite_note-19">[19]</a> <div class="mw-heading mw-heading3"><h3 id="Role_in_females">Role in females</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=4" title="Edit section: Role in females">edit</a>]</div> The AR plays a role in regulating female sexual, somatic, and behavioral functions. Experimental data using AR <a href="/wiki/Knockout_mouse" title="Knockout mouse">knockout</a> female mice, provides evidence that the promotion of cardiac growth, kidney hypertrophy, cortical bone growth and regulation of <a href="/wiki/Trabecular" class="mw-redirect" title="Trabecular">trabecular</a> bone structure is a result of DNA-binding-dependent actions of the AR in females. Moreover, the importance of understanding female androgen receptors lies in their role in several genetic disorders including androgen insensitivity syndrome (AIS). <a href="/wiki/Complete_androgen_insensitivity_syndrome" title="Complete androgen insensitivity syndrome">Complete</a> (CAIS) and <a href="/wiki/Partial_androgen_insensitivity_syndrome" title="Partial androgen insensitivity syndrome">partial</a> (PAIS) which are a result of <a href="/wiki/Mutation" title="Mutation">mutations</a> in the genes that code for AR. These mutations cause the inactivation of AR due to mutations conferring resistance to circulating testosterone, with more than 400 different AR mutations reported.[<a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed">citation needed</a>] <div class="mw-heading mw-heading3"><h3 id="Mechanism_of_action">Mechanism of action</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=5" title="Edit section: Mechanism of action">edit</a>]</div> <div class="mw-heading mw-heading4"><h4 id="Genomic">Genomic</h4>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=6" title="Edit section: Genomic">edit</a>]</div> The primary mechanism of action for androgen receptors is <a href="/wiki/Transcription_factor" title="Transcription factor">direct regulation</a> of <a href="/wiki/Gene_transcription" class="mw-redirect" title="Gene transcription">gene transcription</a>. Androgens (also called androgenic hormones), such as testosterone or dihydrotestosterone, are understood to exert their primary effects through binding to an androgen receptor in the cytosol. The receptor is translocated to the nucleus upon androgen binding and ultimately results in the transcriptional regulation of a number of genes via androgen responsive elements.<a href="#cite_note-pmid12089231-20">[20]</a> This androgen response mechanism is perhaps best known and characterized in the context of male sexual differentiation and puberty, but plays a role in a variety of tissue types and processes.<a href="#cite_note-21">[21]</a><a href="#cite_note-wj-22">[22]</a> Upon binding to androgens, the androgen receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen-responsive genes.<a href="#cite_note-pmid22872761-23">[23]</a> The binding of an androgen to the androgen receptor results in a <a href="/wiki/Conformational_change" title="Conformational change">conformational change</a> in the receptor that, in turn, causes dissociation of <a href="/wiki/Heat_shock_protein" title="Heat shock protein">heat shock proteins</a>, transport from the <a href="/wiki/Cytosol" title="Cytosol">cytosol</a> into the <a href="/wiki/Cell_nucleus" title="Cell nucleus">cell nucleus</a>, and <a href="/wiki/Dimerization_(chemistry)" class="mw-redirect" title="Dimerization (chemistry)">dimerization</a>. The androgen receptor dimer binds to a specific sequence of DNA known as a <a href="/wiki/Hormone_response_element" class="mw-redirect" title="Hormone response element">hormone response element</a>, where it forms macromolacular protein condensates that might facilitate rapid gene regulation as consequence of local high protein concentrations together with other coregulators.<a href="#cite_note-pmid37791849-24">[24]</a> Androgen receptors interact with other proteins in the nucleus, resulting in up- or down-regulation of specific <a href="/wiki/Gene" title="Gene">gene</a> transcription.<a href="#cite_note-pmid17940184-25">[25]</a> Up-regulation or activation of transcription results in increased synthesis of <a href="/wiki/Messenger_RNA" title="Messenger RNA">messenger RNA</a>, which, in turn, is translated by <a href="/wiki/Ribosomes" class="mw-redirect" title="Ribosomes">ribosomes</a> to produce specific proteins. One of the known target genes of androgen receptor activation is the <a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">insulin-like growth factor 1 receptor</a> (IGF-1R).<a href="#cite_note-pmid15753383-26">[26]</a> Thus, changes in levels of specific proteins in cells is one way that androgen receptors control cell behavior. One function of androgen receptor that is independent of direct binding to its target DNA sequence is facilitated by recruitment via other <a href="/wiki/DNA-binding_protein" title="DNA-binding protein">DNA-binding proteins</a>. One example is <a href="/wiki/Serum_response_factor" title="Serum response factor">serum response factor</a>, a protein that activates several genes that cause muscle growth.<a href="#cite_note-pmid15623502-27">[27]</a> Androgen receptor is modified by <a href="/wiki/Post-translational_modification" title="Post-translational modification">post-translational modification</a> through <a href="/wiki/Acetylation" title="Acetylation">acetylation</a>,<a href="#cite_note-28">[28]</a> which directly promotes AR-mediated <a href="/wiki/Transactivation" title="Transactivation">transactivation</a>, <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a><a href="#cite_note-29">[29]</a> and contact-independent growth of <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a> cells.<a href="#cite_note-30">[30]</a> AR acetylation is induced by androgens<a href="#cite_note-31">[31]</a> and determines recruitment into <a href="/wiki/Chromatin" title="Chromatin">chromatin</a>.<a href="#cite_note-32">[32]</a> The AR acetylation site is a key target of <a href="/wiki/Nicotinamide_adenine_dinucleotide" title="Nicotinamide adenine dinucleotide">NAD</a>-dependent and <a href="/wiki/Trichostatin_A" title="Trichostatin A">TSA</a>-dependent <a href="/wiki/Histone_deacetylase" title="Histone deacetylase">histone deacetylases</a><a href="#cite_note-pmid16923962-33">[33]</a> and <a href="/wiki/Long_non-coding_RNA" title="Long non-coding RNA">long non-coding RNA</a>.<a href="#cite_note-34">[34]</a> <div class="mw-heading mw-heading4"><h4 id="Non-genomic">Non-genomic</h4>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=7" title="Edit section: Non-genomic">edit</a>]</div> More recently, androgen receptors have been shown to have a second mode of action. As has been also found for other <a href="/wiki/Steroid_hormone_receptors" class="mw-redirect" title="Steroid hormone receptors">steroid hormone receptors</a> such as <a href="/wiki/Estrogen_receptor" title="Estrogen receptor">estrogen receptors</a>, androgen receptors can have actions that are independent of their interactions with DNA.<a href="#cite_note-pmid12351684-14">[14]</a><a href="#cite_note-Fix_2004-35">[35]</a> Androgen receptors interact with certain <a href="/wiki/Signal_transduction" title="Signal transduction">signal transduction</a> proteins in the cytoplasm. Androgen binding to cytoplasmic androgen receptors can cause rapid changes in cell function independent of changes in gene transcription, such as changes in <a href="/wiki/Ion_channel" title="Ion channel">ion transport</a>. Regulation of signal transduction pathways by cytoplasmic androgen receptors can indirectly lead to changes in gene transcription, for example, by leading to phosphorylation of other transcription factors. <div class="mw-heading mw-heading2"><h2 id="Genetics">Genetics</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=8" title="Edit section: Genetics">edit</a>]</div> <div class="mw-heading mw-heading3"><h3 id="Gene">Gene</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=9" title="Edit section: Gene">edit</a>]</div> In humans, the androgen receptor is encoded by the AR <a href="/wiki/Gene" title="Gene">gene</a> located on the <a href="/wiki/X_chromosome" title="X chromosome">X chromosome</a> at Xq11–12.<a href="#cite_note-pmid3353726-36">[36]</a><a href="#cite_note-pmid3377788-37">[37]</a> <div class="mw-heading mw-heading3"><h3 id="Deficiencies">Deficiencies</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=10" title="Edit section: Deficiencies">edit</a>]</div> At least 165 disease-causing mutations in this gene have been discovered.<a href="#cite_note-Šimčíková_2019_-_supplementary_table_S7-38">[38]</a> The <a href="/wiki/Androgen_insensitivity_syndrome" title="Androgen insensitivity syndrome">androgen insensitivity syndrome</a>, formerly known as testicular feminization, is caused by a mutation in the androgen receptor gene on the <a href="/wiki/X_chromosome" title="X chromosome">X chromosome</a> (locus: Xq11–Xq12).<a href="#cite_note-pmid8537246-39">[39]</a> The androgen receptor seems to affect neuron physiology and is defective in <a href="/wiki/Kennedy%27s_disease" class="mw-redirect" title="Kennedy's disease">Kennedy's disease</a>.<a href="#cite_note-pmid4233749-40">[40]</a><a href="#cite_note-pmid16981011-41">[41]</a> In addition, <a href="/wiki/Point_mutation" title="Point mutation">point mutations</a> and <a href="/wiki/Trinucleotide_repeat_expansion" title="Trinucleotide repeat expansion">trinucleotide repeat</a> <a href="/wiki/Gene_polymorphism" title="Gene polymorphism">polymorphisms</a> have been linked to a number of additional disorders.<a href="#cite_note-pmid17334586-42">[42]</a> <div class="mw-heading mw-heading3"><h3 id="CAG_repeats">CAG repeats</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=11" title="Edit section: CAG repeats">edit</a>]</div> The AR gene contains <a href="/wiki/CAG_repeat" class="mw-redirect" title="CAG repeat">CAG repeats</a> that affect receptor function, where fewer repeats leads to increased receptor sensitivity to circulating androgens and more repeats leads to decreased receptor sensitivity. Studies have shown that racial variation in CAG repeats exists,<a href="#cite_note-pmid9933058-43">[43]</a><a href="#cite_note-pmid29584789-44">[44]</a> with African-Americans having fewer repeats than non-Hispanic white Americans.<a href="#cite_note-pmid9933058-43">[43]</a> The racial trends in CAG repeats parallels the incidence and mortality of prostate cancer in these two groups. <div class="mw-heading mw-heading3"><h3 id="Mutations">Mutations</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=12" title="Edit section: Mutations">edit</a>]</div> The <a href="/wiki/Enhancer_(genetics)" title="Enhancer (genetics)">enhancer</a> and the gene encoding for these receptors contain recurrent mutations, such as structural rearrangements and copy number changes, acquired in the progression of metastatic castration-resistant prostate cancer (mCRPC) treatment with therapy targeting these receptors (abiraterone, <a href="/wiki/Enzalutamide" title="Enzalutamide">enzalutamide</a>), make the disease progression determined by the androgen receptor genotype.<a href="#cite_note-Herberts2022-45">[45]</a> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=13" title="Edit section: Structure">edit</a>]</div> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Human_androgen_receptor.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Human_androgen_receptor.png/330px-Human_androgen_receptor.png" decoding="async" width="294" height="177" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Human_androgen_receptor.png/500px-Human_androgen_receptor.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/7d/Human_androgen_receptor.png/960px-Human_androgen_receptor.png 2x" data-file-width="1660" data-file-height="998" /></a><figcaption>Structure of full length human androgen receptor including N-terminal domain, DNA binding domain, and Ligand binding domain. Corresponding PDB file is available at Sheikhhassani et al.<a href="#cite_note-Sheikhhassani_2022-46">[46]</a> </figcaption></figure> <figure typeof="mw:File/Thumb"><a href="/wiki/File:Androgen_receptor_sequence.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Androgen_receptor_sequence.png/294px-Androgen_receptor_sequence.png" decoding="async" width="294" height="227" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/99/Androgen_receptor_sequence.png/441px-Androgen_receptor_sequence.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/99/Androgen_receptor_sequence.png/588px-Androgen_receptor_sequence.png 2x" data-file-width="1625" data-file-height="1253" /></a><figcaption>Structural domains of the two isoforms (AR-A and AR-B) of the human androgen receptor. Numbers above the bars refer to the amino acid residues that separate the domains starting from the N-terminus (left) to C-terminus (right). NTD = N-terminal domain, DBD = DNA-binding domain, LBD = ligand-binding domain, AF = activation function.</figcaption></figure> <div class="mw-heading mw-heading3"><h3 id="Isoforms">Isoforms</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=14" title="Edit section: Isoforms">edit</a>]</div> Two <a href="/wiki/Protein_isoform" title="Protein isoform">isoforms</a> of the androgen receptor (A and B) have been identified:<a href="#cite_note-pmid8108393-47">[47]</a> <ul><li>AR-A – 87 <a href="/wiki/Atomic_mass_unit" class="mw-redirect" title="Atomic mass unit">kDa</a>; <a href="/wiki/N-terminus" title="N-terminus">N-terminus</a> truncated (lacks the first 187 <a href="/wiki/Amino_acids" class="mw-redirect" title="Amino acids">amino acids</a>), which results from in vitro <a href="/wiki/Proteolysis" title="Proteolysis">proteolysis</a>.<a href="#cite_note-pmid11719283-48">[48]</a></li> <li>AR-B – 110 kDa; full length</li></ul> <div class="mw-heading mw-heading3"><h3 id="Domains">Domains</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=15" title="Edit section: Domains">edit</a>]</div> Like other nuclear receptors, the androgen receptor is modular in structure and is composed of the following functional <a href="/wiki/Structural_domain" class="mw-redirect" title="Structural domain">domains</a> labeled A through F:<a href="#cite_note-pmid2734982-49">[49]</a> <ul><li>A/B) – N-terminal is a regulatory domain which is intrinsically disordered<a href="#cite_note-50">[50]</a> and contains several key motifs/segments:<a href="#cite_note-pmid7706276-51">[51]</a> <ul><li>Dimerization surface involving residues 1–36, the 23FQNLF27 motif<a href="#cite_note-52">[52]</a> (B only) nd 370–494, both of which interact with the ligand binding domain (LBD) in an intramolecular<a href="#cite_note-pmid15994236-53">[53]</a><a href="#cite_note-pmid17189428-54">[54]</a><a href="#cite_note-pmid17420290-55">[55]</a> head-to-tail interaction<a href="#cite_note-pmid8530400-56">[56]</a><a href="#cite_note-pmid9717843-57">[57]</a><a href="#cite_note-pmid15178743-58">[58]</a> <ul><li>FXXLF motif; where F = <a href="/wiki/Phenylalanine" title="Phenylalanine">phenylalanine</a>, L = <a href="/wiki/Leucine" title="Leucine">leucine</a>, and X = any amino acid residue a</li></ul></li> <li>Polyglutamine repeat<a href="#cite_note-59">[59]</a> (AR-B only)</li> <li>Transactivation unit 1 (TAU-1) between residues 101 and 370 required for full <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a>-activated transcriptional activity <a href="#cite_note-Callewaert_2006-60">[60]</a></li> <li>Trans<a href="/wiki/Activation" title="Activation">activation</a> unit 5 (TAU-5) between residues 360–485 is responsible for the <a href="/wiki/Constitutive_activity" class="mw-redirect" title="Constitutive activity">constitutive activity</a> (activity without bound ligand)<a href="#cite_note-Callewaert_2006-60">[60]</a></li></ul></li></ul> Despite being highly disordered, the NTD domain adopts a 3D conformation in which two dynamically compact regions form, an N-terminal region (NR) and a C-terminal region (CR), each having distinct topological dynamics and function.<a href="#cite_note-Sheikhhassani_2022-46">[46]</a> <ul><li>C) – <a href="/wiki/DNA_binding_domain" class="mw-redirect" title="DNA binding domain">DNA binding domain</a> (DBD) <ul><li>Contains two Zinc fingers<a href="#cite_note-61">[61]</a></li></ul></li> <li>D) – Hinge region; flexible region that connects the DBD with the LBD; along with the DBD, contains a ligand dependent <a href="/wiki/Nuclear_localization_signal" class="mw-redirect" title="Nuclear localization signal">nuclear localization signal</a><a href="#cite_note-pmid18420738-62">[62]</a></li> <li>E) – Ligand binding domain (LBD) containing <ul><li>activation function 2 (AF-2), responsible for agonist induced activity (activity in the presence of bound agonist)</li> <li>AF-2 binds either the N-terminal FXXFL motif <a href="/wiki/Intramolecular_force" title="Intramolecular force">intramolecularly</a> or <a href="/wiki/Coactivator_(genetics)" title="Coactivator (genetics)">coactivator</a> proteins (containing the LXXLL or preferably FXXFL motifs)<a href="#cite_note-pmid15178743-58">[58]</a></li> <li>A ligand dependent <a href="/wiki/Nuclear_export_signal" title="Nuclear export signal">nuclear export signal</a><a href="#cite_note-pmid12923188-63">[63]</a></li></ul></li> <li>F) – <a href="/wiki/C-terminal" class="mw-redirect" title="C-terminal">C-terminal</a> domain</li></ul> <div class="mw-heading mw-heading3"><h3 id="Splice_variants">Splice variants</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=16" title="Edit section: Splice variants">edit</a>]</div> AR-V7 is an androgen receptor <a href="/wiki/Splice_variant" class="mw-redirect" title="Splice variant">splice variant</a> that can be detected in <a href="/wiki/Circulating_tumor_cell" title="Circulating tumor cell">circulating tumor cells</a> of metastatic <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a> patients<a href="#cite_note-Silberstein2016-64">[64]</a><a href="#cite_note-Antonarakis2014-65">[65]</a> and is predictive of resistance to some drugs (caused by missing Ligand-binding domain in this splice variant).<a href="#cite_note-66">[66]</a> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=17" title="Edit section: Clinical significance">edit</a>]</div> High expression in androgen receptor has been linked to aggression and sex drive by affecting the HPA and HPG axis<a href="#cite_note-67">[67]</a> Aberrant androgen receptor <a href="/wiki/Transcription_coregulator" title="Transcription coregulator">coregulator</a> activity may contribute to the progression of <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a>.<a href="#cite_note-68">[68]</a><a href="#cite_note-Herberts2022-45">[45]</a> <div class="mw-heading mw-heading2"><h2 id="Ligands">Ligands</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=18" title="Edit section: Ligands">edit</a>]</div> <table class="wikitable floatright" style="width:100px; text-align:left; margin-left:auto; margin-right:auto; border:none;"> <caption><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Affinities_of_selected_androgen_receptor_ligands" title="Template:Affinities of selected androgen receptor ligands"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Affinities_of_selected_androgen_receptor_ligands" title="Template talk:Affinities of selected androgen receptor ligands"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Affinities_of_selected_androgen_receptor_ligands" title="Special:EditPage/Template:Affinities of selected androgen receptor ligands"><abbr title="Edit this template">e</abbr></a></li></ul></div> Affinities<a href="#cite_note-69">[a]</a><a href="#cite_note-pmid2788775-70">[69]</a> </caption> <tbody><tr> <th scope="col">Compound </th> <th scope="col"><a href="/wiki/Relative_binding_affinity" class="mw-redirect" title="Relative binding affinity"><abbr title="Relative binding affinity">RBA</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Relative binding affinity<a href="#cite_note-71">[b]</a> </th></tr> <tr> <th scope="row"><a href="/wiki/Metribolone" title="Metribolone">Metribolone</a> </th> <td>100 </td></tr> <tr> <th scope="row"><a href="/wiki/Androstanolone" title="Androstanolone">Dihydrotestosterone</a> </th> <td>85 </td></tr> <tr> <th scope="row"><a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">Cyproterone acetate</a> </th> <td>7.8 </td></tr> <tr> <th scope="row"><a href="/wiki/Bicalutamide" title="Bicalutamide">Bicalutamide</a> </th> <td>1.4 </td></tr> <tr> <th scope="row"><a href="/wiki/Nilutamide" title="Nilutamide">Nilutamide</a> </th> <td>0.9 </td></tr> <tr> <th scope="row"><a href="/wiki/Hydroxyflutamide" title="Hydroxyflutamide">Hydroxyflutamide</a> </th> <td>0.57 </td></tr> <tr> <th scope="row"><a href="/wiki/Flutamide" title="Flutamide">Flutamide</a> </th> <td><0.0057 </td></tr> <tr class="sortbottom"> <td colspan="2" style="background-color:#FFFFFF; text-align: left; border:none;">Notes: <div style="font-size:85%;"><style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-lower-alpha"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-69"><a href="#cite_ref-69">^</a> At androgen receptors; measured in human prostate tissue. </li> <li id="cite_note-71"><a href="#cite_ref-71">^</a> Relative to <a href="/wiki/Metribolone" title="Metribolone">Metribolone</a>, which is by definition 100% </li> </ol></div></div></div> </td></tr></tbody></table> <div class="mw-heading mw-heading3"><h3 id="Agonists">Agonists</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=19" title="Edit section: Agonists">edit</a>]</div> <ul><li><a href="/wiki/Endogenous" class="mw-redirect" title="Endogenous">Endogenous</a> <a href="/wiki/Androgen" title="Androgen">androgens</a> (e.g., <a href="/wiki/Testosterone" title="Testosterone">testosterone</a>, <a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">dihydrotestosterone</a>, <a href="/wiki/Androstenedione" title="Androstenedione">androstenedione</a>, <a href="/wiki/Androstenediol" title="Androstenediol">androstenediol</a>, <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">dehydroepiandrosterone</a>)</li> <li><a href="/wiki/Synthetic_compound" class="mw-redirect" title="Synthetic compound">Synthetic</a> <a href="/wiki/Androgen" title="Androgen">androgens</a> (e.g., <a href="/wiki/Methyltestosterone" title="Methyltestosterone">methyltestosterone</a>, <a href="/wiki/Metandienone" title="Metandienone">metandienone</a>, <a href="/wiki/Nandrolone" title="Nandrolone">nandrolone</a>, <a href="/wiki/Trenbolone" title="Trenbolone">trenbolone</a>, <a href="/wiki/Oxandrolone" title="Oxandrolone">oxandrolone</a>, <a href="/wiki/Stanozolol" title="Stanozolol">stanozolol</a>)</li></ul> <div class="mw-heading mw-heading3"><h3 id="Mixed">Mixed</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=20" title="Edit section: Mixed">edit</a>]</div> <ul><li><a href="/wiki/Selective_androgen_receptor_modulator" title="Selective androgen receptor modulator">Selective androgen receptor modulators</a> (e.g., <a href="/wiki/Andarine" title="Andarine">andarine</a>, <a href="/wiki/Enobosarm" title="Enobosarm">enobosarm</a>)</li></ul> <div class="mw-heading mw-heading3"><h3 id="Antagonists">Antagonists</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=21" title="Edit section: Antagonists">edit</a>]</div> <ul><li><a href="/wiki/Steroidal_antiandrogen" title="Steroidal antiandrogen">Steroidal antiandrogens</a> (e.g., <a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">cyproterone acetate</a>, <a href="/wiki/Chlormadinone_acetate" title="Chlormadinone acetate">chlormadinone acetate</a>, <a href="/wiki/Spironolactone" title="Spironolactone">spironolactone</a>, <a href="/wiki/Oxendolone" title="Oxendolone">oxendolone</a>)</li> <li><a href="/wiki/Nonsteroidal_antiandrogen" title="Nonsteroidal antiandrogen">Nonsteroidal antiandrogens</a> (e.g., <a href="/wiki/Flutamide" title="Flutamide">flutamide</a>, <a href="/wiki/Nilutamide" title="Nilutamide">nilutamide</a>, <a href="/wiki/Bicalutamide" title="Bicalutamide">bicalutamide</a>, <a href="/wiki/Enzalutamide" title="Enzalutamide">enzalutamide</a>, <a href="/wiki/Apalutamide" title="Apalutamide">apalutamide</a>, <a href="/wiki/RU-58841" title="RU-58841">RU-58841</a>)</li> <li><a href="/wiki/N-Terminal_domain_antiandrogen" title="N-Terminal domain antiandrogen">N-Terminal domain antiandrogens</a> (e.g., <a href="/wiki/Bisphenol_A" title="Bisphenol A">bisphenol A</a>, <a href="/wiki/EPI-001" title="EPI-001">EPI-001</a>, <a href="/wiki/Ralaniten" title="Ralaniten">ralaniten</a>, JN compounds)<a href="#cite_note-Elshan2019-72">[70]</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="As_a_drug_target">As a drug target</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=22" title="Edit section: As a drug target">edit</a>]</div> The AR is an important therapeutic target in <a href="/wiki/Prostate_cancer" title="Prostate cancer">prostate cancer</a>. Thus many different <a href="/wiki/Antiandrogen" title="Antiandrogen">antiandrogens</a> have been developed, primarily targeting the <a href="/wiki/Ligand-binding_domain" class="mw-redirect" title="Ligand-binding domain">ligand-binding domain</a> of the protein.<a href="#cite_note-Helsen_2014-73">[71]</a> AR <a href="/wiki/Ligands" class="mw-redirect" title="Ligands">ligands</a> can either be classified based on their structure (<a href="/wiki/Steroidal" class="mw-redirect" title="Steroidal">steroidal</a> or <a href="/wiki/Nonsteroidal" title="Nonsteroidal">nonsteroidal</a>) or based on their ability to activate or inhibit transcription (<a href="/wiki/Agonists" class="mw-redirect" title="Agonists">agonists</a> or <a href="/wiki/Receptor_antagonist" title="Receptor antagonist">antagonists</a>).<a href="#cite_note-Gao_2005-74">[72]</a> Inhibitors that target alternative functional domains (<a href="/wiki/N-terminal_domain" class="mw-redirect" title="N-terminal domain">N-terminal domain</a>, <a href="/wiki/DNA-binding_domain" title="DNA-binding domain">DNA-binding domain</a>) of the protein are still under development.<a href="#cite_note-Elshan2019-72">[70]</a> <div class="mw-heading mw-heading3"><h3 id="Drug_resistance">Drug resistance</h3>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=23" title="Edit section: Drug resistance">edit</a>]</div> Alteration of ARs may lead to treatment resistance (castration resistance) in prostate cancer as there may be <a href="/wiki/Missense_mutations" class="mw-redirect" title="Missense mutations">missense mutations</a> of the <a href="/wiki/Ligand_binding_domain" class="mw-redirect" title="Ligand binding domain">ligand binding domain</a>, amplifications of the gene coding for this receptor or in its enhancer, mostly, suggesting the presence of different subclones with different genotypes of these receptors.<a href="#cite_note-Herberts2022-45">[45]</a> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=24" title="Edit section: Interactions">edit</a>]</div> Androgen receptor has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/AKT1" title="AKT1">AKT1</a>,<a href="#cite_note-pmid11404460-75">[73]</a></li> <li><a href="/wiki/BAG1" title="BAG1">BAG1</a>,<a href="#cite_note-pmid14517289-76">[74]</a><a href="#cite_note-pmid11278763-77">[75]</a><a href="#cite_note-pmid9565586-78">[76]</a></li> <li><a href="/wiki/Beta-catenin" class="mw-redirect" title="Beta-catenin">Beta-catenin</a>,<a href="#cite_note-pmid14593076-79">[77]</a><a href="#cite_note-pmid15256534-80">[78]</a><a href="#cite_note-pmid11792709-81">[79]</a><a href="#cite_note-pmid12799378-82">[80]</a><a href="#cite_note-pmid12944908-83">[81]</a><a href="#cite_note-pmid11916967-84">[82]</a></li> <li><a href="/wiki/BRCA1" title="BRCA1">BRCA1</a>,<a href="#cite_note-pmid11085509-85">[83]</a><a href="#cite_note-pmid11016951-86">[84]</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">C-jun</a>,<a href="#cite_note-pmid9211894-87">[85]</a></li> <li><a href="/wiki/Calmodulin_1" title="Calmodulin 1">Calmodulin 1</a>,<a href="#cite_note-pmid14695896-88">[86]</a></li> <li><a href="/wiki/Caveolin_1" title="Caveolin 1">Caveolin 1</a>,<a href="#cite_note-pmid11278309-89">[87]</a></li> <li><a href="/wiki/CDK9" class="mw-redirect" title="CDK9">CDK9</a>,<a href="#cite_note-pmid11266437-90">[88]</a></li> <li><a href="/wiki/COX5B" title="COX5B">COX5B</a>,<a href="#cite_note-pmid11719263-91">[89]</a></li> <li><a href="/wiki/CREB-binding_protein" title="CREB-binding protein">CREB-binding protein</a>,<a href="#cite_note-pmid15691881-92">[90]</a><a href="#cite_note-pmid9822653-93">[91]</a><a href="#cite_note-pmid12810069-94">[92]</a><a href="#cite_note-pmid9482849-95">[93]</a></li> <li><a href="/wiki/Cyclin_D1" title="Cyclin D1">Cyclin D1</a>,<a href="#cite_note-96">[94]</a><a href="#cite_note-pmid11328859-97">[95]</a><a href="#cite_note-pmid15558026-98">[96]</a><a href="#cite_note-pmid10344732-99">[97]</a></li> <li><a href="/wiki/Cyclin-dependent_kinase_7" title="Cyclin-dependent kinase 7">Cyclin-dependent kinase 7</a>,<a href="#cite_note-pmid10734072-100">[98]</a></li> <li><a href="/wiki/DACH1" title="DACH1">DACH1</a>,<a href="#cite_note-pmid19351840-101">[99]</a></li> <li><a href="/wiki/Death_associated_protein_6" class="mw-redirect" title="Death associated protein 6">Death associated protein 6</a>,<a href="#cite_note-pmid15572661-102">[100]</a></li> <li><a href="/wiki/L-DOPA" title="L-DOPA">L-DOPA</a>,<a href="#cite_note-pmid12864730-103">[101]</a></li> <li><a href="/wiki/EFCAB6" title="EFCAB6">EFCAB6</a>,<a href="#cite_note-pmid12612053-104">[102]</a></li> <li><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">Epidermal growth factor receptor</a>,<a href="#cite_note-pmid15305378-105">[103]</a><a href="#cite_note-pmid15288768-106">[104]</a></li> <li><a href="/wiki/FOXO1" class="mw-redirect" title="FOXO1">FOXO1</a>,<a href="#cite_note-pmid12482965-107">[105]</a></li> <li><a href="/wiki/Glyceraldehyde_3-phosphate_dehydrogenase" title="Glyceraldehyde 3-phosphate dehydrogenase">GAPDH</a>,<a href="#cite_note-pmid8872471-108">[106]</a></li> <li><a href="/wiki/Gelsolin" title="Gelsolin">Gelsolin</a>,<a href="#cite_note-pmid12941811-109">[107]</a></li> <li><a href="/wiki/GNB2L1" class="mw-redirect" title="GNB2L1">GNB2L1</a>,<a href="#cite_note-pmid12958311-110">[108]</a></li> <li><a href="/wiki/GSK3B" class="mw-redirect" title="GSK3B">GSK3B</a>,<a href="#cite_note-pmid15178691-111">[109]</a></li> <li><a href="/wiki/HDAC1" title="HDAC1">HDAC1</a>,<a href="#cite_note-pmid11994312-112">[110]</a></li> <li><a href="/wiki/Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1" title="Heat shock protein 90kDa alpha (cytosolic), member A1">HSP90AA1</a>,<a href="#cite_note-pmid1540595-113">[111]</a><a href="#cite_note-pmid1525041-114">[112]</a></li> <li><a href="/wiki/HTATIP" class="mw-redirect" title="HTATIP">HTATIP</a>,<a href="#cite_note-pmid11994312-112">[110]</a></li> <li><a href="/wiki/MAGEA11" title="MAGEA11">MAGEA11</a>,<a href="#cite_note-pmid15684378-115">[113]</a><a href="#cite_note-pmid18212060-116">[114]</a></li> <li><a href="/wiki/MED1" title="MED1">MED1</a>,<a href="#cite_note-pmid12218053-117">[115]</a></li> <li><a href="/wiki/MYST2" class="mw-redirect" title="MYST2">MYST2</a>,<a href="#cite_note-pmid10930412-118">[116]</a></li> <li><a href="/wiki/Nuclear_receptor_coactivator_1" title="Nuclear receptor coactivator 1">NCOA1</a>,<a href="#cite_note-pmid15256534-80">[78]</a><a href="#cite_note-pmid12163482-119">[117]</a><a href="#cite_note-pmid10567563-120">[118]</a></li> <li><a href="/wiki/Nuclear_receptor_coactivator_2" title="Nuclear receptor coactivator 2">NCOA2</a>,<a href="#cite_note-pmid14593076-79">[77]</a><a href="#cite_note-pmid12810069-94">[92]</a><a href="#cite_note-pmid15684378-115">[113]</a><a href="#cite_note-pmid14966121-121">[119]</a><a href="#cite_note-pmid12612084-122">[120]</a></li> <li><a href="/wiki/Nuclear_receptor_coactivator_3" title="Nuclear receptor coactivator 3">NCOA3</a>,<a href="#cite_note-pmid14966121-121">[119]</a><a href="#cite_note-pmid10965917-123">[121]</a><a href="#cite_note-pmid11747336-124">[122]</a></li> <li><a href="/wiki/NCOA4" title="NCOA4">NCOA4</a>,<a href="#cite_note-pmid11404460-75">[73]</a><a href="#cite_note-pmid12612084-122">[120]</a><a href="#cite_note-pmid11779876-125">[123]</a><a href="#cite_note-pmid9892017-126">[124]</a><a href="#cite_note-pmid8643607-127">[125]</a><a href="#cite_note-pmid9636157-128">[126]</a><a href="#cite_note-pmid10318905-129">[127]</a><a href="#cite_note-pmid11818501-130">[128]</a><a href="#cite_note-pmid10517667-131">[129]</a></li> <li><a href="/wiki/NCOA6" title="NCOA6">NCOA6</a>,<a href="#cite_note-pmid14645241-132">[130]</a></li> <li><a href="/wiki/Nuclear_receptor_co-repressor_2" title="Nuclear receptor co-repressor 2">NCOR2</a>,<a href="#cite_note-pmid14593076-79">[77]</a><a href="#cite_note-pmid12441355-133">[131]</a><a href="#cite_note-pmid11923464-134">[132]</a></li> <li><a href="/wiki/NONO" class="mw-redirect" title="NONO">NONO</a>,<a href="#cite_note-pmid12810069-94">[92]</a></li> <li><a href="/wiki/EP300" title="EP300">p300</a>,<a href="#cite_note-pmid10779504-135">[133]</a></li> <li><a href="/wiki/PA2G4" title="PA2G4">PA2G4</a>,<a href="#cite_note-pmid12165860-136">[134]</a></li> <li><a href="/wiki/PAK6" title="PAK6">PAK6</a>,<a href="#cite_note-pmid11278661-137">[135]</a><a href="#cite_note-pmid11773441-138">[136]</a></li> <li><a href="/wiki/PATZ1" title="PATZ1">PATZ1</a>,<a href="#cite_note-pmid11719514-139">[137]</a></li> <li><a href="/wiki/Protein_inhibitor_of_activated_STAT2" title="Protein inhibitor of activated STAT2">PIAS2</a>,<a href="#cite_note-pmid11117529-140">[138]</a><a href="#cite_note-pmid9920921-141">[139]</a></li> <li><a href="/wiki/PRPF6" title="PRPF6">PRPF6</a>,<a href="#cite_note-pmid12039962-142">[140]</a></li> <li><a href="/wiki/PTEN_(gene)" title="PTEN (gene)">PTEN</a>,<a href="#cite_note-pmid15205473-143">[141]</a></li> <li><a href="/wiki/RAD9A" title="RAD9A">RAD9A</a>,<a href="#cite_note-pmid14966297-144">[142]</a></li> <li><a href="/wiki/RANBP9" title="RANBP9">RANBP9</a>,<a href="#cite_note-pmid12361945-145">[143]</a></li> <li><a href="/wiki/RCHY1" title="RCHY1">RCHY1</a>,<a href="#cite_note-pmid12200228-146">[144]</a></li> <li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Retinoblastoma protein</a>,<a href="#cite_note-pmid9813067-147">[145]</a><a href="#cite_note-pmid9675141-148">[146]</a></li> <li><a href="/wiki/RNF14" title="RNF14">RNF14</a>,<a href="#cite_note-pmid12612084-122">[120]</a><a href="#cite_note-pmid11779876-125">[123]</a><a href="#cite_note-pmid11673464-149">[147]</a><a href="#cite_note-pmid10085091-150">[148]</a></li> <li><a href="/wiki/RNF4" title="RNF4">RNF4</a>,<a href="#cite_note-pmid11719514-139">[137]</a><a href="#cite_note-pmid9710597-151">[149]</a><a href="#cite_note-pmid10617653-152">[150]</a></li> <li><a href="/wiki/SART3" title="SART3">SART3</a>,<a href="#cite_note-pmid15031286-153">[151]</a></li> <li><a href="/wiki/SIRT1" class="mw-redirect" title="SIRT1">SIRT1</a>,<a href="#cite_note-pmid16923962-33">[33]</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">SMAD3</a>,<a href="#cite_note-pmid11707452-154">[152]</a><a href="#cite_note-pmid11280774-155">[153]</a><a href="#cite_note-pmid12226080-156">[154]</a></li> <li><a href="/wiki/Small_heterodimer_partner" title="Small heterodimer partner">Small heterodimer partner</a>,<a href="#cite_note-pmid11735420-157">[155]</a></li> <li><a href="/wiki/Src_(gene)" class="mw-redirect" title="Src (gene)">Src</a>,<a href="#cite_note-pmid15205473-143">[141]</a><a href="#cite_note-pmid15466214-158">[156]</a><a href="#cite_note-pmid15027889-159">[157]</a></li> <li><a href="/wiki/SRY" class="mw-redirect" title="SRY">SRY</a>,<a href="#cite_note-pmid11585838-160">[158]</a></li> <li><a href="/wiki/STAT3" title="STAT3">STAT3</a>,<a href="#cite_note-pmid11322786-161">[159]</a><a href="#cite_note-pmid11751884-162">[160]</a></li> <li><a href="/wiki/SVIL" title="SVIL">SVIL</a>,<a href="#cite_note-pmid11792840-163">[161]</a></li> <li><a href="/wiki/Testicular_receptor_2" title="Testicular receptor 2">Testicular receptor 2</a>,<a href="#cite_note-pmid12949936-164">[162]</a></li> <li><a href="/wiki/Testicular_receptor_4" title="Testicular receptor 4">Testicular receptor 4</a>,<a href="#cite_note-pmid10611280-165">[163]</a></li> <li><a href="/wiki/TGFB1I1" title="TGFB1I1">TGFB1I1</a>,<a href="#cite_note-pmid11779876-125">[123]</a><a href="#cite_note-pmid11856738-166">[164]</a></li> <li><a href="/wiki/TMF1" title="TMF1">TMF1</a>,<a href="#cite_note-pmid10428808-167">[165]</a></li> <li><a href="/wiki/TRIM68" title="TRIM68">TRIM68</a>,<a href="#cite_note-pmid18451177-168">[166]</a></li> <li><a href="/wiki/UBE2I" title="UBE2I">UBE2I</a>,<a href="#cite_note-pmid14593076-79">[77]</a><a href="#cite_note-pmid15256534-80">[78]</a><a href="#cite_note-pmid10383460-169">[167]</a><a href="#cite_note-pmid10654935-170">[168]</a><a href="#cite_note-pmid12089345-171">[169]</a><a href="#cite_note-pmid15598662-172">[170]</a></li> <li><a href="/wiki/UXT" title="UXT">UXT</a>,<a href="#cite_note-pmid11854421-173">[171]</a> and</li> <li><a href="/wiki/ZMIZ1" title="ZMIZ1">ZMIZ1</a>.<a href="#cite_note-pmid14609956-174">[172]</a></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=25" title="Edit section: See also">edit</a>]</div> <ul><li><a href="/wiki/Membrane_androgen_receptor" title="Membrane androgen receptor">Membrane androgen receptor</a></li> <li><a href="/wiki/Discovery_and_development_of_antiandrogens" title="Discovery and development of antiandrogens">Discovery and development of antiandrogens</a></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=26" title="Edit section: References">edit</a>]</div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239543626" /><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1">^ <a href="#cite_ref-refGRCh38Ensembl_1-0">a</a> <a href="#cite_ref-refGRCh38Ensembl_1-1">b</a> <a href="#cite_ref-refGRCh38Ensembl_1-2">c</a> <a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000169083">GRCh38: Ensembl release 89: ENSG00000169083</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017 </li> <li id="cite_note-refGRCm38Ensembl-2">^ <a href="#cite_ref-refGRCm38Ensembl_2-0">a</a> <a href="#cite_ref-refGRCm38Ensembl_2-1">b</a> <a href="#cite_ref-refGRCm38Ensembl_2-2">c</a> <a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000046532">GRCm38: Ensembl release 89: ENSMUSG00000046532</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017 </li> <li id="cite_note-3"><a href="#cite_ref-3">^</a> <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output 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Molecular Biology of the Cell. 13 (2): 670–82. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1091%2Fmbc.01-10-0513">10.1091/mbc.01-10-0513</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65658">65658</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11854421">11854421</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Biology+of+the+Cell&rft.atitle=Identification+and+characterization+of+ART-27%2C+a+novel+coactivator+for+the+androgen+receptor+N+terminus&rft.volume=13&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E670-%3C%2Fspan%3E82&rft.date=2002-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC65658%23id-name%3DPMC&rft_id=info%3Apmid%2F11854421&rft_id=info%3Adoi%2F10.1091%2Fmbc.01-10-0513&rft.aulast=Markus&rft.aufirst=SM&rft.au=Taneja%2C+SS&rft.au=Logan%2C+SK&rft.au=Li%2C+W&rft.au=Ha%2C+S&rft.au=Hittelman%2C+AB&rft.au=Rogatsky%2C+I&rft.au=Garabedian%2C+MJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC65658&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAndrogen+receptor" class="Z3988"> </li> <li id="cite_note-pmid14609956-174"><a href="#cite_ref-pmid14609956_174-0">^</a> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSharmaLiWangZarnegar2003" class="citation journal cs1">Sharma M, Li X, Wang Y, Zarnegar M, Huang CY, Palvimo JJ, et al. (November 2003). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC275443">"hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci"</a>. The EMBO Journal. 22 (22): 6101–14. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Femboj%2Fcdg585">10.1093/emboj/cdg585</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC275443">275443</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14609956">14609956</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+EMBO+Journal&rft.atitle=hZimp10+is+an+androgen+receptor+co-activator+and+forms+a+complex+with+SUMO-1+at+replication+foci&rft.volume=22&rft.issue=22&rft.pages=%3Cspan+class%3D%22nowrap%22%3E6101-%3C%2Fspan%3E14&rft.date=2003-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC275443%23id-name%3DPMC&rft_id=info%3Apmid%2F14609956&rft_id=info%3Adoi%2F10.1093%2Femboj%2Fcdg585&rft.aulast=Sharma&rft.aufirst=M&rft.au=Li%2C+X&rft.au=Wang%2C+Y&rft.au=Zarnegar%2C+M&rft.au=Huang%2C+CY&rft.au=Palvimo%2C+JJ&rft.au=Lim%2C+B&rft.au=Sun%2C+Z&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC275443&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAndrogen+receptor" class="Z3988"> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=27" title="Edit section: Further reading">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin" style=""> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBrinkmann2009" class="citation book cs1">Brinkmann AO (November 2009). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20120222032949/http://www.endotext.org/male/male3/male3.pdf">"Androgen physiology: receptor and metabolic disorders"</a> (PDF). In McLachlan R (ed.). Endocrinology of Male Reproduction. Endotext.org. Archived from <a rel="nofollow" class="external text" href="http://www.endotext.org/male/male3/male3.pdf">the original</a> (PDF) on 2012-02-22. Retrieved 2008-04-29.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Androgen+physiology%3A+receptor+and+metabolic+disorders&rft.btitle=Endocrinology+of+Male+Reproduction&rft.pub=Endotext.org&rft.date=2009-11&rft.aulast=Brinkmann&rft.aufirst=AO&rft_id=http%3A%2F%2Fwww.endotext.org%2Fmale%2Fmale3%2Fmale3.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAndrogen+receptor" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGottlieb2007" class="citation web cs1">Gottlieb B (2007-07-24). <a rel="nofollow" class="external text" href="http://androgendb.mcgill.ca/">"The Androgen Receptor Gene Mutations Database Server"</a>. McGill University. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20080422174339/http://androgendb.mcgill.ca/">Archived</a> from the original on 22 April 2008. Retrieved 2008-04-29.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=The+Androgen+Receptor+Gene+Mutations+Database+Server&rft.pub=McGill+University&rft.date=2007-07-24&rft.aulast=Gottlieb&rft.aufirst=B&rft_id=http%3A%2F%2Fandrogendb.mcgill.ca%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAndrogen+receptor" class="Z3988"></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFThompson2006" class="citation thesis cs1">Thompson J (2006-09-30). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20080406084901/http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/thompson/molecula.pdf">Molecular Mechanisms of Androgen Receptor Interactions</a> (PDF) (Ph.D. thesis). University of Helsinki. Biomedical Dissertations No. 80. Archived from <a rel="nofollow" class="external text" href="http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/thompson/molecula.pdf">the original</a> (PDF) on 6 April 2008. Retrieved 2008-04-29.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adissertation&rft.title=Molecular+Mechanisms+of+Androgen+Receptor+Interactions&rft.degree=Ph.D.&rft.inst=University+of+Helsinki&rft.date=2006-09-30&rft.aulast=Thompson&rft.aufirst=J&rft_id=http%3A%2F%2Fethesis.helsinki.fi%2Fjulkaisut%2Flaa%2Fbiola%2Fvk%2Fthompson%2Fmolecula.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAndrogen+receptor" class="Z3988"></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2>[<a href="/w/index.php?title=Androgen_receptor&action=edit&section=28" title="Edit section: External links">edit</a>]</div> <style data-mw-deduplicate="TemplateStyles:r1235681985">.mw-parser-output .side-box{margin:4px 0;box-sizing:border-box;border:1px solid #aaa;font-size:88%;line-height:1.25em;background-color:var(--background-color-interactive-subtle,#f8f9fa);display:flow-root}.mw-parser-output .side-box-abovebelow,.mw-parser-output .side-box-text{padding:0.25em 0.9em}.mw-parser-output .side-box-image{padding:2px 0 2px 0.9em;text-align:center}.mw-parser-output .side-box-imageright{padding:2px 0.9em 2px 0;text-align:center}@media(min-width:500px){.mw-parser-output .side-box-flex{display:flex;align-items:center}.mw-parser-output .side-box-text{flex:1;min-width:0}}@media(min-width:720px){.mw-parser-output .side-box{width:238px}.mw-parser-output .side-box-right{clear:right;float:right;margin-left:1em}.mw-parser-output .side-box-left{margin-right:1em}}</style><style data-mw-deduplicate="TemplateStyles:r1237033735">@media print{body.ns-0 .mw-parser-output .sistersitebox{display:none!important}}@media screen{html.skin-theme-clientpref-night .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .sistersitebox img[src*="Wiktionary-logo-en-v2.svg"]{background-color:white}}</style><div class="side-box side-box-right plainlinks sistersitebox"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style> <div class="side-box-flex"> <div class="side-box-image"><a href="/wiki/File:Commons-logo.svg" class="mw-file-description"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/40px-Commons-logo.svg.png" decoding="async" width="30" height="40" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/4/4a/Commons-logo.svg/60px-Commons-logo.svg.png 1.5x" data-file-width="1024" data-file-height="1376" /></a></div> <div class="side-box-text plainlist">Wikimedia Commons has media related to <a href="https://commons.wikimedia.org/wiki/Category:Androgen_receptor" class="extiw" title="commons:Category:Androgen receptor">Androgen receptor</a>.</div></div> </div> <ul><li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/books/NBK1429/">GeneReviews/NCBI/NIH/UW entry on Androgen Insensitivity Syndrome</a></li> <li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/300068,313700,300068,313700">OMIM entries on Androgen Insensitivity Syndrome</a></li> <li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=kennedy">GeneReviews/NIH/NCBI/UW entry on Spinal and Bulbar Muscular Atrophy, Kennedy's Disease, SBMA, X-Linked Spinal and Bulbar Muscular Atrophy</a></li> <li><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/313200,313700,313200,313700">OMIM entries on Spinal and Bulbar Muscular Atrophy, Kennedy's Disease, SBMA, X-Linked Spinal and Bulbar Muscular Atrophy</a></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Androgen+Receptors">Androgen+Receptors</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Human <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&singleSearch=knownCanonical&position=AR">AR</a> genome location and <a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_type=knownGene&hgg_gene=AR">AR</a> gene details page in the <a href="/wiki/UCSC_Genome_Browser" title="UCSC Genome Browser">UCSC Genome Browser</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P10275">P10275</a> (Human Androgen receptor) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P19091">P19091</a> (Mouse Androgen receptor) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output 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id="Transcription_factors_and_intracellular_receptors178" style="font-size:114%;margin:0 4em"><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factors</a> and <a href="/wiki/Intracellular_receptor" title="Intracellular receptor">intracellular receptors</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(1)_Basic_domains178" style="font-size:114%;margin:0 4em">(1) Basic domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(1.1) Basic <a href="/wiki/Leucine_zipper" title="Leucine zipper">leucine zipper</a> (<a href="/wiki/BZIP_domain" title="BZIP domain">bZIP</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_transcription_factor" title="Activating transcription factor">Activating transcription factor</a> <ul><li><a href="/wiki/Apoptosis-antagonizing_transcription_factor" class="mw-redirect" title="Apoptosis-antagonizing transcription factor">AATF</a></li> <li><a href="/wiki/ATF1" title="ATF1">1</a></li> <li><a href="/wiki/Activating_transcription_factor_2" title="Activating transcription factor 2">2</a></li> <li><a href="/wiki/ATF3" title="ATF3">3</a></li> <li><a href="/wiki/ATF4" title="ATF4">4</a></li> <li><a href="/wiki/ATF5" title="ATF5">5</a></li> <li><a href="/wiki/ATF6" title="ATF6">6</a></li> <li><a href="/wiki/ATF7" title="ATF7">7</a></li></ul></li> <li><a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> <ul><li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li> <li><a href="/wiki/FOSB" title="FOSB">FOSB</a></li> <li><a href="/wiki/FOSL1" title="FOSL1">FOSL1</a></li> <li><a href="/wiki/FOSL2" title="FOSL2">FOSL2</a></li> <li><a href="/wiki/Jun_dimerization_protein" title="Jun dimerization protein">JDP2</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li> <li><a href="/wiki/JUNB" title="JUNB">JUNB</a></li> <li><a href="/wiki/JunD" title="JunD">JunD</a></li></ul></li> <li>BACH <ul><li><a href="/wiki/BACH1" title="BACH1">1</a></li> <li><a href="/wiki/BACH2" title="BACH2">2</a></li></ul></li> <li><a href="/wiki/BATF_(gene)" title="BATF (gene)">BATF</a></li> <li><a href="/wiki/BLZF1" title="BLZF1">BLZF1</a></li> <li><a href="/wiki/Ccaat-enhancer-binding_proteins" class="mw-redirect" title="Ccaat-enhancer-binding proteins">C/EBP</a> <ul><li><a href="/wiki/CEBPA" title="CEBPA">α</a></li> <li><a href="/wiki/CEBPB" title="CEBPB">β</a></li> <li><a href="/wiki/CEBPG" title="CEBPG">γ</a></li> <li><a href="/wiki/CEBPD" title="CEBPD">δ</a></li> <li><a href="/wiki/CEBPE" title="CEBPE">ε</a></li> <li><a href="/wiki/CCAAT/enhancer_binding_protein_zeta" title="CCAAT/enhancer binding protein zeta">ζ</a></li></ul></li> <li><a href="/wiki/CREB" title="CREB">CREB</a> <ul><li><a href="/wiki/CREB1" title="CREB1">1</a></li> <li><a href="/wiki/CREB3" title="CREB3">3</a></li> <li><a href="/wiki/CREBL1" title="CREBL1">L1</a></li></ul></li> <li><a href="/wiki/CAMP_responsive_element_modulator" title="CAMP responsive element modulator">CREM</a></li> <li><a href="/wiki/DBP_(gene)" title="DBP (gene)">DBP</a></li> <li><a href="/wiki/DNA_damage-inducible_transcript_3" title="DNA damage-inducible transcript 3">DDIT3</a></li> <li><a href="/wiki/GABPA" title="GABPA">GABPA</a></li> <li><a href="/wiki/Gcn4" title="Gcn4">GCN4</a></li> <li><a href="/wiki/HLF_(gene)" title="HLF (gene)">HLF</a></li> <li><a href="/wiki/MAF_(gene)" title="MAF (gene)">MAF</a> <ul><li><a href="/wiki/MAFB_(gene)" title="MAFB (gene)">B</a></li> <li><a href="/wiki/Small_Maf" title="Small Maf">sMaf</a> <ul><li><a href="/wiki/MAFF_(gene)" title="MAFF (gene)">F</a></li> <li><a href="/wiki/MAFG" title="MAFG">G</a></li> <li><a href="/wiki/MAFK" title="MAFK">K</a></li></ul></li></ul></li> <li>NFE <ul><li><a href="/wiki/NFE2" title="NFE2">2</a></li> <li><a href="/wiki/NFE2L1" title="NFE2L1">L1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">L2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">L3</a></li></ul></li> <li><a href="/wiki/NFIL3" title="NFIL3">NFIL3</a></li> <li><a href="/wiki/NRL_(gene)" title="NRL (gene)">NRL</a></li> <li>NRF <ul><li><a href="/wiki/NRF1" title="NRF1">1</a></li> <li><a href="/wiki/NFE2L2" title="NFE2L2">2</a></li> <li><a href="/wiki/NFE2L3" title="NFE2L3">3</a></li></ul></li> <li><a href="/wiki/XBP1" title="XBP1">XBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(1.2) Basic helix-loop-helix (<a href="/wiki/Basic_helix-loop-helix" class="mw-redirect" title="Basic helix-loop-helix">bHLH</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Group A</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Achaete-scute_complex" title="Achaete-scute complex">AS-C</a> <ul><li><a href="/wiki/ASCL1" title="ASCL1">ASCL1</a></li> <li><a href="/wiki/ASCL2" title="ASCL2">ASCL2</a></li></ul></li> <li><a href="/wiki/ATOH1" title="ATOH1">ATOH1</a></li> <li>HAND <ul><li><a href="/wiki/HAND1" title="HAND1">1</a></li> <li><a href="/wiki/HAND2" title="HAND2">2</a></li></ul></li> <li><a href="/wiki/MESP2" title="MESP2">MESP2</a></li> <li><a href="/wiki/Myogenic_regulatory_factors" title="Myogenic regulatory factors">Myogenic regulatory factors</a> <ul><li><a href="/wiki/MyoD" title="MyoD">MyoD</a></li> <li><a href="/wiki/Myogenin" title="Myogenin">Myogenin</a></li> <li><a href="/wiki/MYF5" title="MYF5">MYF5</a></li> <li><a href="/wiki/MYF6" title="MYF6">MYF6</a></li></ul></li> <li><a href="/wiki/NeuroD" title="NeuroD">NeuroD</a> <ul><li><a href="/wiki/NEUROD1" title="NEUROD1">1</a></li> <li><a href="/wiki/NEUROD2" title="NEUROD2">2</a></li></ul></li> <li><a href="/wiki/Neurogenins" title="Neurogenins">Neurogenins</a> <ul><li><a href="/wiki/NEUROG1" class="mw-redirect" title="NEUROG1">1</a></li> <li><a href="/wiki/NEUROG2" class="mw-redirect" title="NEUROG2">2</a></li> <li><a href="/wiki/NEUROG3" class="mw-redirect" title="NEUROG3">3</a></li></ul></li> <li>OLIG <ul><li><a href="/wiki/OLIG1" title="OLIG1">1</a></li> <li><a href="/wiki/OLIG2" title="OLIG2">2</a></li></ul></li> <li>Paraxis <ul><li><a href="/wiki/TCF15" title="TCF15">TCF15</a></li> <li><a href="/wiki/Scleraxis" title="Scleraxis">Scleraxis</a></li></ul></li> <li>SLC <ul><li><a href="/wiki/LYL1" title="LYL1">LYL1</a></li> <li>TAL <ul><li><a href="/wiki/TAL1" title="TAL1">1</a></li> <li><a href="/wiki/TAL2" title="TAL2">2</a></li></ul></li></ul></li> <li><a href="/wiki/Twist_transcription_factor" class="mw-redirect" title="Twist transcription factor">Twist</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Group B</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FIGLA" title="FIGLA">FIGLA</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a> <ul><li><a href="/wiki/MYC" title="MYC">c-Myc</a></li> <li><a href="/wiki/MYCL" title="MYCL">l-Myc</a></li> <li><a href="/wiki/N-Myc" title="N-Myc">n-Myc</a></li></ul></li> <li><a href="/wiki/MXD4" title="MXD4">MXD4</a></li> <li><a href="/wiki/TCF4" title="TCF4">TCF4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Group C bHLH-<a href="/wiki/PAS_domain" title="PAS domain">PAS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aryl_hydrocarbon_receptor" title="Aryl hydrocarbon receptor">AhR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_repressor" title="Aryl hydrocarbon receptor repressor">AHRR</a></li> <li><a href="/wiki/Aryl_hydrocarbon_receptor_nuclear_translocator" title="Aryl hydrocarbon receptor nuclear translocator">ARNT</a> <ul><li><a href="/wiki/ARNTL" class="mw-redirect" title="ARNTL">ARNTL</a></li> <li><a href="/wiki/ARNTL2" title="ARNTL2">ARNTL2</a></li></ul></li> <li><a href="/wiki/CLOCK" title="CLOCK">CLOCK</a></li> <li><a href="/wiki/Hypoxia-inducible_factor" title="Hypoxia-inducible factor">HIF</a> <ul><li><a href="/wiki/HIF1A" title="HIF1A">1A</a></li> <li><a href="/wiki/EPAS1" title="EPAS1">EPAS1</a></li> <li><a href="/wiki/HIF3A" title="HIF3A">3A</a></li></ul></li> <li>NPAS <ul><li><a href="/wiki/NPAS1" title="NPAS1">1</a></li> <li><a href="/wiki/NPAS2" title="NPAS2">2</a></li> <li><a href="/wiki/NPAS3" title="NPAS3">3</a></li></ul></li> <li>PER <ul><li><a href="/wiki/PER1" class="mw-redirect" title="PER1">1</a></li> <li><a href="/wiki/PER2" title="PER2">2</a></li> <li><a href="/wiki/PER3" title="PER3">3</a></li> <li><a href="/wiki/Period_(gene)" title="Period (gene)">Period</a></li></ul></li> <li>SIM <ul><li><a href="/wiki/SIM1" title="SIM1">1</a></li> <li><a href="/wiki/SIM2" title="SIM2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Group D</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>BHLH <ul><li><a href="/wiki/BHLHB2" title="BHLHB2">2</a></li> <li><a href="/wiki/BHLHB3" class="mw-redirect" title="BHLHB3">3</a></li> <li><a href="/wiki/BHLHA9" title="BHLHA9">9</a></li></ul></li> <li><a href="/wiki/Pho4" title="Pho4">Pho4</a></li> <li>ID <ul><li><a href="/wiki/ID1" title="ID1">1</a></li> <li><a href="/wiki/ID2" title="ID2">2</a></li> <li><a href="/wiki/ID3_(gene)" title="ID3 (gene)">3</a></li> <li><a href="/wiki/ID4" title="ID4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Group E</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>HES <ul><li><a href="/wiki/HES1" title="HES1">1</a></li> <li><a href="/wiki/Hes_family_bhlh_transcription_factor_2" title="Hes family bhlh transcription factor 2">2</a></li> <li><a href="/wiki/HES3" title="HES3">3</a></li> <li><a href="/wiki/HES4" title="HES4">4</a></li> <li><a href="/wiki/HES5" title="HES5">5</a></li> <li><a href="/wiki/HES6" title="HES6">6</a></li> <li><a href="/wiki/HES7_gene" title="HES7 gene">7</a></li></ul></li> <li>HEY <ul><li><a href="/wiki/HEY1" title="HEY1">1</a></li> <li><a href="/wiki/HEY2" title="HEY2">2</a></li> <li><a href="/wiki/HEYL" title="HEYL">L</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Group F bHLH-COE</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EBF1" title="EBF1">EBF1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(1.3) <a href="/wiki/Basic_helix-loop-helix_leucine_zipper_transcription_factors" title="Basic helix-loop-helix leucine zipper transcription factors">bHLH-ZIP</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFAP4" title="TFAP4">AP-4</a></li> <li><a href="/wiki/MAX_(gene)" title="MAX (gene)">MAX</a> <ul><li><a href="/wiki/MXD1" title="MXD1">MXD1</a></li> <li><a href="/wiki/MXD3" title="MXD3">MXD3</a></li></ul></li> <li><a href="/wiki/Microphthalmia-associated_transcription_factor" title="Microphthalmia-associated transcription factor">MITF</a></li> <li><a href="/wiki/MNT_(gene)" title="MNT (gene)">MNT</a></li> <li><a href="/wiki/MLX_(gene)" title="MLX (gene)">MLX</a></li> <li><a href="/wiki/Carbohydrate-responsive_element-binding_protein" title="Carbohydrate-responsive element-binding protein">MLXIPL</a></li> <li><a href="/wiki/MXI1" title="MXI1">MXI1</a></li> <li><a href="/wiki/Myc" title="Myc">Myc</a></li> <li><a href="/wiki/Sterol_regulatory_element-binding_protein" title="Sterol regulatory element-binding protein">SREBP</a> <ul><li><a href="/wiki/SREBF1" class="mw-redirect" title="SREBF1">1</a></li> <li><a href="/wiki/SREBF2" class="mw-redirect" title="SREBF2">2</a></li></ul></li> <li><a href="/wiki/USF1" title="USF1">USF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(1.4) NF-1</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nuclear_factor_I" title="Nuclear factor I">NFI</a> <ul><li><a href="/wiki/NFIA" title="NFIA">A</a></li> <li><a href="/wiki/NFIB_(gene)" title="NFIB (gene)">B</a></li> <li><a href="/wiki/NFIC_(gene)" title="NFIC (gene)">C</a></li> <li><a href="/wiki/NFIX" title="NFIX">X</a></li></ul></li> <li><a href="/wiki/SMAD_(protein)" title="SMAD (protein)">SMAD</a> <ul><li><a href="/wiki/R-SMAD" title="R-SMAD">R-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_1" title="Mothers against decapentaplegic homolog 1">1</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_3" title="Mothers against decapentaplegic homolog 3">3</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_5" title="Mothers against decapentaplegic homolog 5">5</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_9" title="Mothers against decapentaplegic homolog 9">9</a></li></ul></li> <li><a href="/wiki/I-SMAD" title="I-SMAD">I-SMAD</a> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_6" title="Mothers against decapentaplegic homolog 6">6</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_7" title="Mothers against decapentaplegic homolog 7">7</a></li></ul></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">4</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(1.5) RF-X</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li>RFX <ul><li><a href="/wiki/RFX1" title="RFX1">1</a></li> <li><a href="/wiki/RFX2" title="RFX2">2</a></li> <li><a href="/wiki/RFX3" title="RFX3">3</a></li> <li><a href="/wiki/RFX4" title="RFX4">4</a></li> <li><a href="/wiki/RFX5" title="RFX5">5</a></li> <li><a href="/wiki/RFX6" title="RFX6">6</a></li> <li><a href="/wiki/RFXANK" title="RFXANK">ANK</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(1.6) Basic helix-span-helix (bHSH)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Activating_protein_2" title="Activating protein 2">AP-2</a> <ul><li><a href="/wiki/TFAP2A" title="TFAP2A">α</a></li> <li><a href="/wiki/TFAP2B" title="TFAP2B">β</a></li> <li><a href="/wiki/TFAP2C" title="TFAP2C">γ</a></li> <li><a href="/wiki/TFAP2D" title="TFAP2D">δ</a></li> <li><a href="/wiki/TFAP2E" title="TFAP2E">ε</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible uncollapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(2)_Zinc_finger_DNA-binding_domains178" style="font-size:114%;margin:0 4em">(2) <a href="/wiki/Zinc_finger" title="Zinc finger">Zinc finger</a> DNA-binding domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(2.1) <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">Nuclear receptor</a> (Cys4)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">subfamily 1</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thyroid_hormone_receptor" title="Thyroid hormone receptor">Thyroid hormone</a> <ul><li><a href="/wiki/Thyroid_hormone_receptor_alpha" title="Thyroid hormone receptor alpha">α</a></li> <li><a href="/wiki/Thyroid_hormone_receptor_beta" title="Thyroid hormone receptor beta">β</a></li></ul></li> <li><a href="/wiki/Constitutive_androstane_receptor" title="Constitutive androstane receptor">CAR</a></li> <li><a href="/wiki/Farnesoid_X_receptor" title="Farnesoid X receptor">FXR</a></li> <li><a href="/wiki/Liver_X_receptor" title="Liver X receptor">LXR</a> <ul><li><a href="/wiki/Liver_X_receptor_alpha" title="Liver X receptor alpha">α</a></li> <li><a href="/wiki/Liver_X_receptor_beta" title="Liver X receptor beta">β</a></li></ul></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor" title="Peroxisome proliferator-activated receptor">PPAR</a> <ul><li><a href="/wiki/Peroxisome_proliferator-activated_receptor_alpha" title="Peroxisome proliferator-activated receptor alpha">α</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_delta" title="Peroxisome proliferator-activated receptor delta">β/δ</a></li> <li><a href="/wiki/Peroxisome_proliferator-activated_receptor_gamma" title="Peroxisome proliferator-activated receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Pregnane_X_receptor" title="Pregnane X receptor">PXR</a></li> <li><a href="/wiki/Retinoic_acid_receptor" title="Retinoic acid receptor">RAR</a> <ul><li><a href="/wiki/Retinoic_acid_receptor_alpha" title="Retinoic acid receptor alpha">α</a></li> <li><a href="/wiki/Retinoic_acid_receptor_beta" title="Retinoic acid receptor beta">β</a></li> <li><a href="/wiki/Retinoic_acid_receptor_gamma" title="Retinoic acid receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/RAR-related_orphan_receptor" title="RAR-related orphan receptor">ROR</a> <ul><li><a href="/wiki/RAR-related_orphan_receptor_alpha" title="RAR-related orphan receptor alpha">α</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_beta" title="RAR-related orphan receptor beta">β</a></li> <li><a href="/wiki/RAR-related_orphan_receptor_gamma" title="RAR-related orphan receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Rev-ErbA" class="mw-redirect" title="Rev-ErbA">Rev-ErbA</a> <ul><li><a href="/wiki/Rev-ErbA_alpha" title="Rev-ErbA alpha">α</a></li> <li><a href="/wiki/Rev-ErbA_beta" title="Rev-ErbA beta">β</a></li></ul></li> <li><a href="/wiki/Calcitriol_receptor" class="mw-redirect" title="Calcitriol receptor">VDR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">subfamily 2</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Chicken_ovalbumin_upstream_promoter-transcription_factor" title="Chicken ovalbumin upstream promoter-transcription factor">COUP-TF</a> <ul><li>(<a href="/wiki/COUP-TFI" title="COUP-TFI">I</a></li> <li><a href="/wiki/COUP-TFII" title="COUP-TFII">II</a></li></ul></li> <li><a href="/wiki/V-erbA-related_gene" title="V-erbA-related gene">Ear-2</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4" title="Hepatocyte nuclear factor 4">HNF4</a> <ul><li><a href="/wiki/Hepatocyte_nuclear_factor_4_alpha" title="Hepatocyte nuclear factor 4 alpha">α</a></li> <li><a href="/wiki/Hepatocyte_nuclear_factor_4_gamma" title="Hepatocyte nuclear factor 4 gamma">γ</a></li></ul></li> <li><a href="/wiki/Photoreceptor_cell-specific_nuclear_receptor" title="Photoreceptor cell-specific nuclear receptor">PNR</a></li> <li><a href="/wiki/Retinoid_X_receptor" title="Retinoid X receptor">RXR</a> <ul><li><a href="/wiki/Retinoid_X_receptor_alpha" title="Retinoid X receptor alpha">α</a></li> <li><a href="/wiki/Retinoid_X_receptor_beta" title="Retinoid X receptor beta">β</a></li> <li><a href="/wiki/Retinoid_X_receptor_gamma" title="Retinoid X receptor gamma">γ</a></li></ul></li> <li><a href="/wiki/Testicular_receptor" title="Testicular receptor">Testicular receptor</a> <ul><li><a href="/wiki/Testicular_receptor_2" title="Testicular receptor 2">2</a></li> <li><a href="/wiki/Testicular_receptor_4" title="Testicular receptor 4">4</a></li></ul></li> <li><a href="/wiki/TLX" title="TLX">TLX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">subfamily 3</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Steroid_hormone_receptor" title="Steroid hormone receptor">Steroid hormone</a> <ul><li><a class="mw-selflink selflink">Androgen</a></li> <li><a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen</a> <ul><li><a href="/wiki/Estrogen_receptor_alpha" title="Estrogen receptor alpha">α</a></li> <li><a href="/wiki/Estrogen_receptor_beta" title="Estrogen receptor beta">β</a></li></ul></li> <li><a href="/wiki/Glucocorticoid_receptor" title="Glucocorticoid receptor">Glucocorticoid</a></li> <li><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid</a></li> <li><a href="/wiki/Progesterone_receptor" title="Progesterone receptor">Progesterone</a></li></ul></li> <li><a href="/wiki/Estrogen-related_receptor" title="Estrogen-related receptor">Estrogen related</a> <ul><li><a href="/wiki/Estrogen-related_receptor_alpha" title="Estrogen-related receptor alpha">α</a></li> <li><a href="/wiki/Estrogen-related_receptor_beta" title="Estrogen-related receptor beta">β</a></li> <li><a href="/wiki/Estrogen-related_receptor_gamma" title="Estrogen-related receptor gamma">γ</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">subfamily 4</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Nur_(biology)" class="mw-redirect" title="Nur (biology)">NUR</a> <ul><li><a href="/wiki/Nuclear_receptor_4A1" title="Nuclear receptor 4A1">NGFIB</a></li> <li><a href="/wiki/Nuclear_receptor_4A3" title="Nuclear receptor 4A3">NOR1</a></li> <li><a href="/wiki/Nuclear_receptor_4A2" title="Nuclear receptor 4A2">NURR1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">subfamily 5</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Liver_receptor_homolog-1" title="Liver receptor homolog-1">LRH-1</a></li> <li><a href="/wiki/Steroidogenic_factor_1" title="Steroidogenic factor 1">SF1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">subfamily 6</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Germ_cell_nuclear_factor" title="Germ cell nuclear factor">GCNF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">subfamily 0</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DAX1" title="DAX1">DAX1</a></li> <li><a href="/wiki/Small_heterodimer_partner" title="Small heterodimer partner">SHP</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(2.2) Other Cys4</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/GATA_transcription_factor" title="GATA transcription factor">GATA</a> <ul><li><a href="/wiki/GATA1" title="GATA1">1</a></li> <li><a href="/wiki/GATA2" title="GATA2">2</a></li> <li><a href="/wiki/GATA3" title="GATA3">3</a></li> <li><a href="/wiki/GATA4" title="GATA4">4</a></li> <li><a href="/wiki/GATA5" title="GATA5">5</a></li> <li><a href="/wiki/GATA6" title="GATA6">6</a></li></ul></li> <li>MTA <ul><li><a href="/wiki/MTA1" title="MTA1">1</a></li> <li><a href="/wiki/MTA2" title="MTA2">2</a></li> <li><a href="/wiki/MTA3" title="MTA3">3</a></li></ul></li> <li><a href="/wiki/Tricho-rhino-phalangeal_syndrome_Type_1" title="Tricho-rhino-phalangeal syndrome Type 1">TRPS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(2.3) Cys2His2</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/General_transcription_factor" title="General transcription factor">General transcription factors</a> <ul><li><a href="/wiki/Transcription_factor_II_A" title="Transcription factor II A">TFIIA</a></li> <li><a href="/wiki/Transcription_factor_II_B" title="Transcription factor II B">TFIIB</a></li> <li><a href="/wiki/Transcription_factor_II_D" title="Transcription factor II D">TFIID</a></li> <li><a href="/wiki/Transcription_factor_II_E" title="Transcription factor II E">TFIIE</a> <ul><li><a href="/wiki/GTF2E1" title="GTF2E1">1</a></li> <li><a href="/wiki/GTF2E2" title="GTF2E2">2</a></li></ul></li> <li><a href="/wiki/Transcription_factor_II_F" title="Transcription factor II F">TFIIF</a></li> <li><a href="/wiki/GTF2F1" title="GTF2F1">1</a></li> <li><a href="/wiki/GTF2F2" title="GTF2F2">2</a> <ul><li><a href="/wiki/Transcription_factor_II_H" title="Transcription factor II H">TFIIH</a></li> <li><a href="/wiki/GTF2H1" title="GTF2H1">1</a></li> <li><a href="/wiki/GTF2H2" title="GTF2H2">2</a></li> <li><a href="/wiki/GTF2H4" title="GTF2H4">4</a></li> <li><a href="/wiki/GTF2I" title="GTF2I">2I</a></li> <li><a href="/wiki/GTF3A" title="GTF3A">3A</a></li> <li><a href="/wiki/GTF3C1" title="GTF3C1">3C1</a></li> <li><a href="/wiki/GTF3C2" title="GTF3C2">3C2</a></li></ul></li></ul></li></ul> <ul><li><a href="/wiki/ATBF1" title="ATBF1">ATBF1</a></li> <li><a href="/wiki/B-cell_CLL/lymphoma" title="B-cell CLL/lymphoma">BCL</a> <ul><li><a href="/wiki/BCL6" title="BCL6">6</a></li> <li><a href="/wiki/BCL11A" title="BCL11A">11A</a></li> <li><a href="/wiki/BCL11B" title="BCL11B">11B</a></li></ul></li> <li><a href="/wiki/CTCF" title="CTCF">CTCF</a></li> <li><a href="/wiki/E4F1" title="E4F1">E4F1</a></li> <li><a href="/wiki/Early_growth_response_proteins" title="Early growth response proteins">EGR</a> <ul><li><a href="/wiki/EGR1" title="EGR1">1</a></li> <li><a href="/wiki/EGR2" title="EGR2">2</a></li> <li><a href="/wiki/EGR3" title="EGR3">3</a></li> <li><a href="/wiki/EGR4" title="EGR4">4</a></li></ul></li> <li><a href="/wiki/ERV3" title="ERV3">ERV3</a></li> <li><a href="/wiki/GFI1" title="GFI1">GFI1</a></li> <li>GLI family <ul><li><a href="/wiki/GLI1" title="GLI1">1</a></li> <li><a href="/wiki/GLI2" title="GLI2">2</a></li> <li><a href="/wiki/GLI3" title="GLI3">3</a></li> <li><a href="/wiki/RE1-silencing_transcription_factor" title="RE1-silencing transcription factor">REST</a></li> <li><a href="/wiki/GLIS1" title="GLIS1">S1</a></li> <li><a href="/wiki/GLIS2" title="GLIS2">S2</a></li> <li><a href="/wiki/YY1" title="YY1">YY1</a></li></ul></li> <li>HIC <ul><li><a href="/wiki/HIC1" title="HIC1">1</a></li> <li><a href="/wiki/HIC2" title="HIC2">2</a></li></ul></li> <li>HIVEP <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">1</a></li> <li><a href="/wiki/HIVEP2" title="HIVEP2">2</a></li> <li><a href="/wiki/HIVEP3" title="HIVEP3">3</a></li></ul></li> <li>IKZF <ul><li><a href="/wiki/IKZF1" title="IKZF1">1</a></li> <li><a href="/wiki/IKZF2" title="IKZF2">2</a></li> <li><a href="/wiki/IKZF3" title="IKZF3">3</a></li></ul></li> <li>ILF <ul><li><a href="/wiki/ILF2" title="ILF2">2</a></li> <li><a href="/wiki/ILF3" title="ILF3">3</a></li></ul></li> <li><a href="/wiki/Kruppel-like_factors" title="Kruppel-like factors">Sp/KLF family</a> <ul><li>KLF <ul><li><a href="/wiki/KLF1" title="KLF1">1</a></li> <li><a href="/wiki/KLF2" title="KLF2">2</a></li> <li><a href="/wiki/KLF3" title="KLF3">3</a></li> <li><a href="/wiki/KLF4" title="KLF4">4</a></li> <li><a href="/wiki/KLF5" title="KLF5">5</a></li> <li><a href="/wiki/KLF6" title="KLF6">6</a></li> <li><a href="/wiki/KLF7" title="KLF7">7</a></li> <li><a href="/wiki/KLF8" title="KLF8">8</a></li> <li><a href="/wiki/KLF9" title="KLF9">9</a></li> <li><a href="/wiki/KLF10" title="KLF10">10</a></li> <li><a href="/wiki/KLF11" title="KLF11">11</a></li> <li><a href="/wiki/KLF12" title="KLF12">12</a></li> <li><a href="/wiki/KLF13" title="KLF13">13</a></li> <li><a href="/wiki/KLF14" title="KLF14">14</a></li> <li><a href="/wiki/KLF15" title="KLF15">15</a></li> <li><a href="/wiki/KLF17" title="KLF17">17</a></li></ul></li> <li>SP <ul><li><a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">1</a></li> <li><a href="/wiki/SP2_(gene)" class="mw-redirect" title="SP2 (gene)">2</a></li> <li><a href="/wiki/SP4_(gene)" class="mw-redirect" title="SP4 (gene)">4</a></li> <li><a href="/wiki/Sp7_transcription_factor" title="Sp7 transcription factor">7</a></li> <li><a href="/wiki/Sp8_transcription_factor" title="Sp8 transcription factor">8</a></li></ul></li></ul></li> <li><a href="/wiki/MTF1" title="MTF1">MTF1</a></li> <li><a href="/wiki/MYT1" title="MYT1">MYT1</a></li> <li><a href="/wiki/OSR1" title="OSR1">OSR1</a></li> <li><a href="/wiki/PRDM9" title="PRDM9">PRDM9</a></li> <li>SALL <ul><li><a href="/wiki/SALL1" title="SALL1">1</a></li> <li><a href="/wiki/SALL2" title="SALL2">2</a></li> <li><a href="/wiki/SALL3" title="SALL3">3</a></li> <li><a href="/wiki/SALL4" title="SALL4">4</a></li></ul></li> <li><a href="/wiki/TSHZ3" title="TSHZ3">TSHZ3</a></li> <li><a href="/wiki/WT1" class="mw-redirect" title="WT1">WT1</a></li> <li><a href="/wiki/Zbtb7" title="Zbtb7">Zbtb7</a> <ul><li><a href="/wiki/ZBTB7A" title="ZBTB7A">7A</a></li> <li><a href="/wiki/ZBTB7B" title="ZBTB7B">7B</a></li></ul></li> <li>ZBTB <ul><li><a href="/wiki/ZBTB11" title="ZBTB11">11</a></li> <li><a href="/wiki/Zinc_finger_and_BTB_domain-containing_protein_16" title="Zinc finger and BTB domain-containing protein 16">16</a></li> <li><a href="/wiki/ZBTB17" title="ZBTB17">17</a></li> <li><a href="/wiki/ZBTB20" title="ZBTB20">20</a></li> <li><a href="/wiki/ZBTB21" title="ZBTB21">21</a></li> <li><a href="/wiki/ZBTB32" title="ZBTB32">32</a></li> <li><a href="/wiki/ZBTB33" title="ZBTB33">33</a></li> <li><a href="/wiki/ZBTB40" title="ZBTB40">40</a></li></ul></li> <li>zinc finger <ul><li><a href="/wiki/ZNF3" title="ZNF3">3</a></li> <li><a href="/wiki/ZNF7" title="ZNF7">7</a></li> <li><a href="/wiki/CNBP" title="CNBP">9</a></li> <li><a href="/wiki/ZNF10" title="ZNF10">10</a></li> <li><a href="/wiki/ZNF19" title="ZNF19">19</a></li> <li><a href="/wiki/ZNF22" title="ZNF22">22</a></li> <li><a href="/wiki/ZNF24" title="ZNF24">24</a></li> <li><a href="/wiki/ZNF33B" title="ZNF33B">33B</a></li> <li><a href="/wiki/ZNF34" title="ZNF34">34</a></li> <li><a href="/wiki/ZNF35" title="ZNF35">35</a></li> <li><a href="/wiki/ZNF41" title="ZNF41">41</a></li> <li><a href="/wiki/ZNF43" title="ZNF43">43</a></li> <li><a href="/wiki/ZNF44" title="ZNF44">44</a></li> <li><a href="/wiki/BCL6" title="BCL6">51</a></li> <li><a href="/wiki/ZNF74" title="ZNF74">74</a></li> <li><a href="/wiki/ZNF143" title="ZNF143">143</a></li> <li><a href="/wiki/ZNF146" title="ZNF146">146</a></li> <li><a href="/wiki/ZNF148" title="ZNF148">148</a></li> <li><a href="/wiki/Zinc_finger_protein_165" title="Zinc finger protein 165">165</a></li> <li><a href="/wiki/ZNF202" title="ZNF202">202</a></li> <li><a href="/wiki/ZNF217" title="ZNF217">217</a></li> <li><a href="/wiki/ZNF219" title="ZNF219">219</a></li> <li><a href="/wiki/ZNF238" title="ZNF238">238</a></li> <li><a href="/wiki/ZNF239" title="ZNF239">239</a></li> <li><a href="/wiki/ZNF259" title="ZNF259">259</a></li> <li><a href="/wiki/ZNF267" title="ZNF267">267</a></li> <li><a href="/wiki/EGR1" title="EGR1">268</a></li> <li><a href="/wiki/ZNF281" title="ZNF281">281</a></li> <li><a href="/wiki/ZNF300" title="ZNF300">300</a></li> <li><a href="/wiki/ZNF318" title="ZNF318">318</a></li> <li><a href="/wiki/ZNF330" title="ZNF330">330</a></li> <li><a href="/wiki/ZNF346" title="ZNF346">346</a></li> <li><a href="/wiki/ZNF350" title="ZNF350">350</a></li> <li><a href="/wiki/ZNF365" title="ZNF365">365</a></li> <li><a href="/wiki/ZNF366" title="ZNF366">366</a></li> <li><a href="/wiki/ZNF384" title="ZNF384">384</a></li> <li><a href="/wiki/ZNF423" title="ZNF423">423</a></li> <li><a href="/wiki/ZNF451" title="ZNF451">451</a></li> <li><a href="/wiki/ZNF452" title="ZNF452">452</a></li> <li><a href="/wiki/ZNF471" title="ZNF471">471</a></li> <li><a href="/wiki/ZNF593" title="ZNF593">593</a></li> <li><a href="/wiki/ZNF638" title="ZNF638">638</a></li> <li><a href="/wiki/ZNF644" title="ZNF644">644</a></li> <li><a href="/wiki/ZNF649" title="ZNF649">649</a></li> <li><a href="/wiki/ZNF655" title="ZNF655">655</a></li> <li><a href="/wiki/ZNF804A" class="mw-redirect" title="ZNF804A">804A</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(2.4) Cys6</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HIVEP1" title="HIVEP1">HIVEP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(2.5) Alternating composition</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Autoimmune_regulator" title="Autoimmune regulator">AIRE</a></li> <li><a href="/wiki/DIDO1" title="DIDO1">DIDO1</a></li> <li><a href="/wiki/GRLF1" title="GRLF1">GRLF1</a></li> <li>ING <ul><li><a href="/wiki/ING1" title="ING1">1</a></li> <li><a href="/wiki/ING2" title="ING2">2</a></li> <li><a href="/wiki/ING4" title="ING4">4</a></li></ul></li> <li>JARID <ul><li><a href="/wiki/KDM5A" title="KDM5A">1A</a></li> <li><a href="/wiki/KDM5B" class="mw-redirect" title="KDM5B">1B</a></li> <li><a href="/wiki/KDM5C" title="KDM5C">1C</a></li> <li><a href="/wiki/KDM5D" title="KDM5D">1D</a></li> <li><a href="/wiki/JARID2" title="JARID2">2</a></li></ul></li> <li><a href="/wiki/KDM3B" title="KDM3B">JMJD1B</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(2.6) WRKY</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/WRKY_protein_domain" title="WRKY protein domain">WRKY</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(3)_Helix-turn-helix_domains178" style="font-size:114%;margin:0 4em">(3) <a href="/wiki/Helix-turn-helix" title="Helix-turn-helix">Helix-turn-helix</a> domains</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(3.1) <a href="/wiki/Homeodomain_fold" class="mw-redirect" title="Homeodomain fold">Homeodomain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Antennapedia" title="Antennapedia">Antennapedia</a> ANTP class</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">protoHOX Hox-like</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ParaHox" title="ParaHox">ParaHox</a> <ul><li><a href="/wiki/Gsx_(gene_family)" title="Gsx (gene family)">Gsx</a> <ul><li><a href="/wiki/GSX1" title="GSX1">1</a></li> <li><a href="/wiki/GSX2" title="GSX2">2</a></li></ul></li> <li><a href="/wiki/Xlox" class="mw-redirect" title="Xlox">Xlox</a> <ul><li><a href="/wiki/PDX1" title="PDX1">PDX1</a></li></ul></li> <li><a href="/wiki/Cdx" title="Cdx">Cdx</a> <ul><li><a href="/wiki/CDX1" class="mw-redirect" title="CDX1">1</a></li> <li><a href="/wiki/CDX2" class="mw-redirect" title="CDX2">2</a></li> <li><a href="/wiki/CDX4_(gene)" class="mw-redirect" title="CDX4 (gene)">4</a></li></ul></li></ul></li> <li>extended Hox: <a href="/wiki/Evx1" title="Evx1">Evx1</a></li> <li><a href="/w/index.php?title=Evx2&action=edit&redlink=1" class="new" title="Evx2 (page does not exist)">Evx2</a></li> <li><a href="/wiki/MEOX1" title="MEOX1">MEOX1</a></li> <li><a href="/wiki/MEOX2" title="MEOX2">MEOX2</a></li> <li><a href="/wiki/Homeobox" title="Homeobox">Homeobox</a> <ul><li><a href="/wiki/Homeobox_A1" title="Homeobox A1">A1</a></li> <li><a href="/wiki/HOXA2" title="HOXA2">A2</a></li> <li><a href="/wiki/HOXA3" title="HOXA3">A3</a></li> <li><a href="/wiki/HOXA4" title="HOXA4">A4</a></li> <li><a href="/wiki/HOXA5" title="HOXA5">A5</a></li> <li><a href="/wiki/HOXA7" title="HOXA7">A7</a></li> <li><a href="/wiki/HOXA9" title="HOXA9">A9</a></li> <li><a href="/wiki/Homeobox_A10" title="Homeobox A10">A10</a></li> <li><a href="/wiki/HOXA11" title="HOXA11">A11</a></li> <li><a href="/wiki/HOXA13" title="HOXA13">A13</a></li> <li><a href="/wiki/HOXB1" title="HOXB1">B1</a></li> <li><a href="/wiki/HOXB2" title="HOXB2">B2</a></li> <li><a href="/wiki/HOXB3" title="HOXB3">B3</a></li> <li><a href="/wiki/HOXB4" title="HOXB4">B4</a></li> <li><a href="/wiki/HOXB5" title="HOXB5">B5</a></li> <li><a href="/wiki/HOXB6" title="HOXB6">B6</a></li> <li><a href="/wiki/HOXB7" title="HOXB7">B7</a></li> <li><a href="/wiki/HOXB8" title="HOXB8">B8</a></li> <li><a href="/wiki/HOXB9" title="HOXB9">B9</a></li> <li><a href="/wiki/HOXB13" title="HOXB13">B13</a></li> <li><a href="/wiki/HOXC4" title="HOXC4">C4</a></li> <li><a href="/wiki/HOXC5" title="HOXC5">C5</a></li> <li><a href="/wiki/HOXC6" title="HOXC6">C6</a></li> <li><a href="/wiki/HOXC8" title="HOXC8">C8</a></li> <li><a href="/wiki/HOXC9" title="HOXC9">C9</a></li> <li><a href="/wiki/HOXC10" title="HOXC10">C10</a></li> <li><a href="/wiki/HOXC11" title="HOXC11">C11</a></li> <li><a href="/wiki/HOXC12" title="HOXC12">C12</a></li> <li><a href="/wiki/HOXC13" title="HOXC13">C13</a></li> <li><a href="/wiki/HOXD1" title="HOXD1">D1</a></li> <li><a href="/wiki/HOXD3" title="HOXD3">D3</a></li> <li><a href="/wiki/HOXD4" title="HOXD4">D4</a></li> <li><a href="/wiki/HOXD8" title="HOXD8">D8</a></li> <li><a href="/wiki/HOXD9" title="HOXD9">D9</a></li> <li><a href="/wiki/HOXD10" title="HOXD10">D10</a></li> <li><a href="/wiki/HOXD11" title="HOXD11">D11</a></li> <li><a href="/wiki/HOXD12" title="HOXD12">D12</a></li> <li><a href="/wiki/HOXD13" title="HOXD13">D13</a></li></ul></li> <li><a href="/w/index.php?title=GBX1&action=edit&redlink=1" class="new" title="GBX1 (page does not exist)">GBX1</a></li> <li><a href="/wiki/GBX2" title="GBX2">GBX2</a></li> <li><a href="/wiki/MNX1" title="MNX1">MNX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">metaHOX NK-like</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=BARHL1&action=edit&redlink=1" class="new" title="BARHL1 (page does not exist)">BARHL1</a></li> <li><a href="/wiki/BARHL2" title="BARHL2">BARHL2</a></li> <li><a href="/w/index.php?title=BARX1&action=edit&redlink=1" class="new" title="BARX1 (page does not exist)">BARX1</a></li> <li><a href="/w/index.php?title=BARX2&action=edit&redlink=1" class="new" title="BARX2 (page does not exist)">BARX2</a></li> <li><a href="/wiki/Brain-specific_homeobox" title="Brain-specific homeobox">BSX</a></li> <li>DBX <ul><li><a href="/wiki/DBX1" title="DBX1">1</a></li> <li><a href="/wiki/DBX2" title="DBX2">2</a></li></ul></li> <li><a href="/wiki/DLX_gene_family" title="DLX gene family">DLX</a> <ul><li><a href="/wiki/DLX1" title="DLX1">1</a></li> <li><a href="/wiki/DLX2" title="DLX2">2</a></li> <li><a href="/wiki/DLX3_(gene)" class="mw-redirect" title="DLX3 (gene)">3</a></li> <li><a href="/wiki/DLX4" title="DLX4">4</a></li> <li><a href="/wiki/DLX5" title="DLX5">5</a></li> <li><a href="/wiki/DLX6" title="DLX6">6</a></li></ul></li> <li><a href="/wiki/EMX_homeogene" title="EMX homeogene">EMX</a> <ul><li><a href="/wiki/EMX1" title="EMX1">1</a></li> <li><a href="/wiki/EMX2" title="EMX2">2</a></li></ul></li> <li>EN <ul><li><a href="/wiki/EN1_(gene)" title="EN1 (gene)">1</a></li> <li><a href="/wiki/EN2_(gene)" title="EN2 (gene)">2</a></li></ul></li> <li><a href="/wiki/HHEX" title="HHEX">HHEX</a></li> <li><a href="/wiki/HLX_(gene)" title="HLX (gene)">HLX</a></li> <li><a href="/wiki/LBX1" title="LBX1">LBX1</a></li> <li><a href="/wiki/LBX2" title="LBX2">LBX2</a></li> <li>MSX <ul><li><a href="/wiki/MSX1" class="mw-redirect" title="MSX1">1</a></li> <li><a href="/wiki/Msh_homeobox_2" title="Msh homeobox 2">2</a></li></ul></li> <li><a href="/wiki/Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li> <li><a href="/wiki/NKX-homeodomain_factor" title="NKX-homeodomain factor">NKX</a> <ul><li><a href="/wiki/NK2_homeobox_1" title="NK2 homeobox 1">2-1</a></li> <li><a href="/wiki/NKX2-2" title="NKX2-2">2-2</a></li> <li><a href="/wiki/NKX2-3" title="NKX2-3">2-3</a></li> <li><a href="/wiki/Homeobox_protein_Nkx-2.5" title="Homeobox protein Nkx-2.5">2-5</a></li> <li><a href="/wiki/NKX3-1" title="NKX3-1">3-1</a></li> <li><a href="/wiki/NKX3-2" title="NKX3-2">3-2</a></li> <li><a href="/w/index.php?title=HMX1&action=edit&redlink=1" class="new" title="HMX1 (page does not exist)">HMX1</a></li> <li><a href="/w/index.php?title=HMX2&action=edit&redlink=1" class="new" title="HMX2 (page does not exist)">HMX2</a></li> <li><a href="/w/index.php?title=HMX3&action=edit&redlink=1" class="new" title="HMX3 (page does not exist)">HMX3</a></li> <li><a href="/wiki/NKX6-1" title="NKX6-1">6-1</a></li> <li><a href="/wiki/NKX6-2" title="NKX6-2">6-2</a></li></ul></li> <li><a href="/wiki/Notochord_homeobox_(NOTO)_gene" title="Notochord homeobox (NOTO) gene">NOTO</a></li> <li><a href="/wiki/TLX1" title="TLX1">TLX1</a></li> <li><a href="/wiki/TLX2" title="TLX2">TLX2</a></li> <li><a href="/wiki/TLX3" title="TLX3">TLX3</a></li> <li><a href="/wiki/VAX1" title="VAX1">VAX1</a></li> <li><a href="/w/index.php?title=VAX2&action=edit&redlink=1" class="new" title="VAX2 (page does not exist)">VAX2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">other</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aristaless_related_homeobox" title="Aristaless related homeobox">ARX</a></li> <li><a href="/wiki/CRX_(gene)" title="CRX (gene)">CRX</a></li> <li><a href="/wiki/CUTL1" title="CUTL1">CUTL1</a></li> <li>FHL <ul><li><a href="/wiki/FHL1" title="FHL1">1</a></li> <li><a href="/wiki/FHL2" title="FHL2">2</a></li> <li><a href="/wiki/FHL3" title="FHL3">3</a></li></ul></li> <li><a href="/wiki/HESX1" title="HESX1">HESX1</a></li> <li><a href="/wiki/HOPX" title="HOPX">HOPX</a></li> <li>LMX <ul><li><a href="/wiki/LMX1A" title="LMX1A">1A</a></li> <li><a href="/wiki/LMX1B" title="LMX1B">1B</a></li></ul></li> <li><a href="/wiki/NOBOX" title="NOBOX">NOBOX</a></li> <li>TALE <ul><li><a href="/wiki/Iroquois_homeobox_factor" title="Iroquois homeobox factor">IRX</a> <ul><li><a href="/wiki/IRX1" title="IRX1">1</a></li> <li><a href="/wiki/IRX2" title="IRX2">2</a></li> <li><a href="/wiki/IRX3" title="IRX3">3</a></li> <li><a href="/wiki/IRX4" title="IRX4">4</a></li> <li><a href="/wiki/IRX5" title="IRX5">5</a></li> <li><a href="/wiki/IRX6" title="IRX6">6</a></li> <li><a href="/wiki/MKX" title="MKX">MKX</a></li></ul></li> <li>MEIS <ul><li><a href="/wiki/MEIS1" title="MEIS1">1</a></li> <li><a href="/wiki/MEIS2" title="MEIS2">2</a></li></ul></li> <li>PBX <ul><li><a href="/wiki/PBX1" title="PBX1">1</a></li> <li><a href="/wiki/PBX2" title="PBX2">2</a></li> <li><a href="/wiki/PBX3" title="PBX3">3</a></li></ul></li> <li>PKNOX <ul><li><a href="/wiki/PKNOX1" title="PKNOX1">1</a></li> <li><a href="/wiki/PKNOX2" title="PKNOX2">2</a></li></ul></li> <li>SIX <ul><li><a href="/wiki/SIX1" class="mw-redirect" title="SIX1">1</a></li> <li><a href="/wiki/SIX2" title="SIX2">2</a></li> <li><a href="/wiki/SIX3" title="SIX3">3</a></li> <li><a href="/wiki/SIX4" title="SIX4">4</a></li> <li><a href="/wiki/SIX5" title="SIX5">5</a></li></ul></li></ul></li> <li>PHF <ul><li><a href="/wiki/PHF1" title="PHF1">1</a></li> <li><a href="/wiki/PHF3" title="PHF3">3</a></li> <li><a href="/wiki/PHF6" title="PHF6">6</a></li> <li><a href="/wiki/PHF8" title="PHF8">8</a></li> <li><a href="/wiki/PHF10" title="PHF10">10</a></li> <li><a href="/wiki/PHF16" title="PHF16">16</a></li> <li><a href="/wiki/PHF17" class="mw-redirect" title="PHF17">17</a></li> <li><a href="/wiki/PHF20" title="PHF20">20</a></li> <li><a href="/wiki/PHF21A" title="PHF21A">21A</a></li></ul></li> <li><a href="/wiki/POU_domain" title="POU domain">POU domain</a> <ul><li><a href="/wiki/Pituitary-specific_positive_transcription_factor_1" title="Pituitary-specific positive transcription factor 1">PIT-1</a></li> <li><a href="/wiki/BRN-3" title="BRN-3">BRN-3</a>: <a href="/wiki/POU4F1" title="POU4F1">A</a></li> <li><a href="/wiki/POU4F2" title="POU4F2">B</a></li> <li><a href="/wiki/POU4F3" title="POU4F3">C</a></li> <li><a href="/wiki/Octamer_transcription_factor" title="Octamer transcription factor">Octamer transcription factor</a>: <a href="/wiki/POU2F1" title="POU2F1">1</a></li> <li><a href="/wiki/Oct-2" title="Oct-2">2</a></li> <li><a href="/wiki/Oct-4" title="Oct-4">3/4</a></li> <li><a href="/wiki/POU3F1" title="POU3F1">6</a></li> <li><a href="/wiki/POU3F2" title="POU3F2">7</a></li> <li><a href="/wiki/POU3F4" title="POU3F4">11</a></li></ul></li> <li><a href="/wiki/SATB2" title="SATB2">SATB2</a></li> <li>ZEB <ul><li><a href="/wiki/ZEB1" title="ZEB1">1</a></li> <li><a href="/wiki/ZEB2" title="ZEB2">2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(3.2) Paired box</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pax_genes" title="Pax genes">PAX</a> <ul><li><a href="/wiki/PAX1" title="PAX1">1</a></li> <li><a href="/wiki/PAX2" title="PAX2">2</a></li> <li><a href="/wiki/PAX3" title="PAX3">3</a></li> <li><a href="/wiki/PAX4" title="PAX4">4</a></li> <li><a href="/wiki/PAX5" title="PAX5">5</a></li> <li><a href="/wiki/PAX6" title="PAX6">6</a></li> <li><a href="/wiki/PAX7" title="PAX7">7</a></li> <li><a href="/wiki/PAX8" title="PAX8">8</a></li> <li><a href="/wiki/PAX9" title="PAX9">9</a></li></ul></li> <li>PRRX <ul><li><a href="/wiki/PRRX1" title="PRRX1">1</a></li> <li><a href="/wiki/PRRX2" title="PRRX2">2</a></li></ul></li> <li><a href="/wiki/PROP1" title="PROP1">PROP1</a></li> <li>PHOX <ul><li><a href="/wiki/PHOX2A" title="PHOX2A">2A</a></li> <li><a href="/wiki/PHOX2B" title="PHOX2B">2B</a></li></ul></li> <li><a href="/wiki/Retinal_homeobox_protein_Rx" title="Retinal homeobox protein Rx">RAX</a></li> <li><a href="/wiki/Short-stature_homeobox_gene" title="Short-stature homeobox gene">SHOX</a></li> <li><a href="/wiki/SHOX2" title="SHOX2">SHOX2</a></li> <li><a href="/wiki/VSX1" title="VSX1">VSX1</a></li> <li><a href="/wiki/VSX2" title="VSX2">VSX2</a></li> <li><a href="/wiki/Bicoid_(gene)" class="mw-redirect" title="Bicoid (gene)">Bicoid</a> <ul><li><a href="/wiki/Goosecoid_protein" class="mw-redirect" title="Goosecoid protein">GSC</a></li> <li><a href="/wiki/BICD2" title="BICD2">BICD2</a></li> <li>OTX <ul><li><a href="/wiki/OTX1" title="OTX1">1</a></li> <li><a href="/wiki/Orthodenticle_homeobox_2" title="Orthodenticle homeobox 2">2</a></li></ul></li> <li>PITX <ul><li><a href="/wiki/PITX1" title="PITX1">1</a></li> <li><a href="/wiki/PITX2" title="PITX2">2</a></li> <li><a href="/wiki/PITX3" title="PITX3">3</a></li></ul></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(3.3) <a href="/wiki/FOX_proteins" title="FOX proteins">Fork head</a> / <a href="/wiki/Winged-helix_transcription_factors" title="Winged-helix transcription factors">winged helix</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/E2F" title="E2F">E2F</a> <ul><li><a href="/wiki/E2F1" title="E2F1">1</a></li> <li><a href="/wiki/E2F2" title="E2F2">2</a></li> <li><a href="/wiki/E2F3" title="E2F3">3</a></li> <li><a href="/wiki/E2F4" title="E2F4">4</a></li> <li><a href="/wiki/E2F5" title="E2F5">5</a></li></ul></li> <li><a href="/wiki/FOX_proteins" title="FOX proteins">FOX proteins</a> <ul><li><a href="/wiki/FOXA1" title="FOXA1">A1</a></li> <li><a href="/wiki/FOXA2" title="FOXA2">A2</a></li> <li><a href="/wiki/FOXA3" title="FOXA3">A3</a></li> <li><a href="/wiki/FOXB1" class="mw-redirect" title="FOXB1">B1</a></li> <li><a href="/w/index.php?title=FOXB2&action=edit&redlink=1" class="new" title="FOXB2 (page does not exist)">B2</a></li> <li><a href="/wiki/Forkhead_box_C1" title="Forkhead box C1">C1</a></li> <li><a href="/wiki/FOXC2" title="FOXC2">C2</a></li> <li><a href="/wiki/FOXD1" class="mw-redirect" title="FOXD1">D1</a></li> <li><a href="/w/index.php?title=FOXD2&action=edit&redlink=1" class="new" title="FOXD2 (page does not exist)">D2</a></li> <li><a href="/wiki/FOXD3" title="FOXD3">D3</a></li> <li><a href="/wiki/FOXD4" title="FOXD4">D4</a></li> <li><a href="/w/index.php?title=FOXD4L1&action=edit&redlink=1" class="new" title="FOXD4L1 (page does not exist)">D4L1</a></li> <li><a href="/w/index.php?title=FOXD4L3&action=edit&redlink=1" class="new" title="FOXD4L3 (page does not exist)">D4L3</a></li> <li><a href="/w/index.php?title=FOXD4L4&action=edit&redlink=1" class="new" title="FOXD4L4 (page does not exist)">D4L4</a></li> <li><a href="/w/index.php?title=FOXD4L5&action=edit&redlink=1" class="new" title="FOXD4L5 (page does not exist)">D4L5</a></li> <li><a href="/w/index.php?title=FOXD4L6&action=edit&redlink=1" class="new" title="FOXD4L6 (page does not exist)">D4L6</a></li> <li><a href="/wiki/FOXE1" title="FOXE1">E1</a></li> <li><a href="/wiki/FOXE3" title="FOXE3">E3</a></li> <li><a href="/wiki/FOXF1" title="FOXF1">F1</a></li> <li><a href="/wiki/FOXF2" title="FOXF2">F2</a></li> <li><a href="/wiki/FOXG1" title="FOXG1">G1</a></li> <li><a href="/wiki/FOXH1" title="FOXH1">H1</a></li> <li><a href="/wiki/FOXI1" title="FOXI1">I1</a></li> <li><a href="/w/index.php?title=FOXI2&action=edit&redlink=1" class="new" title="FOXI2 (page does not exist)">I2</a></li> <li><a href="/wiki/FOXI3" title="FOXI3">I3</a></li> <li><a href="/wiki/FOXJ1" title="FOXJ1">J1</a></li> <li><a href="/wiki/FOXJ2" title="FOXJ2">J2</a></li> <li><a href="/w/index.php?title=FOXJ3&action=edit&redlink=1" class="new" title="FOXJ3 (page does not exist)">J3</a></li> <li><a href="/wiki/FOXK1" title="FOXK1">K1</a></li> <li><a href="/wiki/FOXK2" title="FOXK2">K2</a></li> <li><a href="/w/index.php?title=FOXL1&action=edit&redlink=1" class="new" title="FOXL1 (page does not exist)">L1</a></li> <li><a href="/wiki/Forkhead_box_L2" class="mw-redirect" title="Forkhead box L2">L2</a></li> <li><a href="/wiki/FOXM1" title="FOXM1">M1</a></li> <li><a href="/wiki/FOXN1" title="FOXN1">N1</a></li> <li><a href="/w/index.php?title=FOXN2&action=edit&redlink=1" class="new" title="FOXN2 (page does not exist)">N2</a></li> <li><a href="/wiki/FOXN3" title="FOXN3">N3</a></li> <li><a href="/w/index.php?title=FOXN4&action=edit&redlink=1" class="new" title="FOXN4 (page does not exist)">N4</a></li> <li><a href="/wiki/FOXO1" class="mw-redirect" title="FOXO1">O1</a></li> <li><a href="/wiki/FOXO3" title="FOXO3">O3</a></li> <li><a href="/wiki/FOXO4" title="FOXO4">O4</a></li> <li><a href="/wiki/FOXO6" title="FOXO6">O6</a></li> <li><a href="/wiki/FOXP1" title="FOXP1">P1</a></li> <li><a href="/wiki/FOXP2" title="FOXP2">P2</a></li> <li><a href="/wiki/FOXP3" title="FOXP3">P3</a></li> <li><a href="/wiki/FOXP4" title="FOXP4">P4</a></li> <li><a href="/wiki/FOXQ1" title="FOXQ1">Q1</a></li> <li><a href="/w/index.php?title=FOXR1&action=edit&redlink=1" class="new" title="FOXR1 (page does not exist)">R1</a></li> <li><a href="/w/index.php?title=FOXR2&action=edit&redlink=1" class="new" title="FOXR2 (page does not exist)">R2</a></li> <li><a href="/wiki/FOXS1" title="FOXS1">S1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(3.4) <a href="/wiki/Heat_shock_factor" title="Heat shock factor">Heat shock factors</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Heat_shock_factor" title="Heat shock factor">HSF</a> <ul><li><a href="/wiki/HSF1" class="mw-redirect" title="HSF1">1</a></li> <li><a href="/wiki/HSF2" title="HSF2">2</a></li> <li><a href="/wiki/HSF4" title="HSF4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(3.5) Tryptophan clusters</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li>ELF <ul><li><a href="/wiki/ELF2" title="ELF2">2</a></li> <li><a href="/wiki/ELF4" title="ELF4">4</a></li> <li><a href="/wiki/ELF5" title="ELF5">5</a></li></ul></li> <li><a href="/wiki/EHF_(gene)" title="EHF (gene)">EHF</a></li> <li>ELK <ul><li><a href="/wiki/ELK1" title="ELK1">1</a></li> <li><a href="/wiki/ELK3" title="ELK3">3</a></li> <li><a href="/wiki/ELK4" title="ELK4">4</a></li></ul></li> <li><a href="/wiki/ERF_(gene)" title="ERF (gene)">ERF</a></li> <li><a href="/wiki/ETS_transcription_factor_family" title="ETS transcription factor family">ETS</a> <ul><li><a href="/wiki/ETS1" title="ETS1">1</a></li> <li><a href="/wiki/ETS2" title="ETS2">2</a></li> <li><a href="/wiki/ERG_(gene)" title="ERG (gene)">ERG</a></li> <li><a href="/wiki/SPIB" title="SPIB">SPIB</a></li></ul></li> <li>ETV <ul><li><a href="/wiki/ETV1" title="ETV1">1</a></li> <li><a href="/wiki/ETV4" title="ETV4">4</a></li> <li><a href="/wiki/ERM_transcription_factor" class="mw-redirect" title="ERM transcription factor">5</a></li> <li><a href="/wiki/ETV6" title="ETV6">6</a></li></ul></li> <li><a href="/wiki/FLI1" title="FLI1">FLI1</a></li> <li><a href="/wiki/Interferon_regulatory_factors" title="Interferon regulatory factors">Interferon regulatory factors</a> <ul><li><a href="/wiki/IRF1" title="IRF1">1</a></li> <li><a href="/wiki/IRF2" title="IRF2">2</a></li> <li><a href="/wiki/IRF3" title="IRF3">3</a></li> <li><a href="/wiki/IRF4" title="IRF4">4</a></li> <li><a href="/wiki/IRF5" title="IRF5">5</a></li> <li><a href="/wiki/IRF6" title="IRF6">6</a></li> <li><a href="/wiki/IRF7" title="IRF7">7</a></li> <li><a href="/wiki/IRF8" title="IRF8">8</a></li></ul></li> <li><a href="/wiki/MYB_(gene)" title="MYB (gene)">MYB</a></li> <li><a href="/wiki/MYBL2" title="MYBL2">MYBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(3.6) TEA domain</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li>transcriptional enhancer factor <ul><li><a href="/wiki/TEAD1" title="TEAD1">1</a></li> <li><a href="/wiki/TEAD2" title="TEAD2">2</a></li> <li><a href="/wiki/TEAD3" title="TEAD3">3</a></li> <li><a href="/wiki/TEAD4" title="TEAD4">4</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(4)_β-Scaffold_factors_with_minor_groove_contacts178" style="font-size:114%;margin:0 4em">(4) β-Scaffold factors with minor groove contacts</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.1) <a href="/wiki/Rel_homology_domain" title="Rel homology domain">Rel homology region</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/NF-%CE%BAB" title="NF-κB">NF-κB</a> <ul><li><a href="/wiki/NFKB1" title="NFKB1">NFKB1</a></li> <li><a href="/wiki/NFKB2" title="NFKB2">NFKB2</a></li> <li><a href="/wiki/REL" title="REL">REL</a></li> <li><a href="/wiki/RELA" title="RELA">RELA</a></li> <li><a href="/wiki/RELB" title="RELB">RELB</a></li></ul></li> <li><a href="/wiki/NFAT" title="NFAT">NFAT</a> <ul><li><a href="/wiki/NFATC1" title="NFATC1">C1</a></li> <li><a href="/wiki/NFATC2" title="NFATC2">C2</a></li> <li><a href="/wiki/NFATC3" title="NFATC3">C3</a></li> <li><a href="/wiki/NFATC4" title="NFATC4">C4</a></li> <li><a href="/wiki/NFAT5" title="NFAT5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.2) <a href="/wiki/STAT_protein" title="STAT protein">STAT</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STAT_protein" title="STAT protein">STAT</a> <ul><li><a href="/wiki/STAT1" title="STAT1">1</a></li> <li><a href="/wiki/STAT2" title="STAT2">2</a></li> <li><a href="/wiki/STAT3" title="STAT3">3</a></li> <li><a href="/wiki/STAT4" title="STAT4">4</a></li> <li><a href="/wiki/STAT5" title="STAT5">5</a></li> <li><a href="/wiki/STAT6" title="STAT6">6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.3) p53-like</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53_p63_p73_family" title="P53 p63 p73 family">p53 p63 p73 family</a> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/TP63" title="TP63">TP63</a></li> <li><a href="/wiki/P73" title="P73">p73</a></li></ul></li> <li><a href="/wiki/T-box" title="T-box">TBX</a> <ul><li><a href="/wiki/TBX1" title="TBX1">1</a></li> <li><a href="/wiki/TBX2" title="TBX2">2</a></li> <li><a href="/wiki/TBX3" title="TBX3">3</a></li> <li><a href="/wiki/TBX5_(gene)" title="TBX5 (gene)">5</a></li> <li><a href="/wiki/TBX19" title="TBX19">19</a></li> <li><a href="/wiki/TBX21" title="TBX21">21</a></li> <li><a href="/wiki/TBX22" title="TBX22">22</a></li> <li><a href="/wiki/TBR1" title="TBR1">TBR1</a></li> <li><a href="/wiki/Eomesodermin" title="Eomesodermin">TBR2</a></li> <li><a href="/wiki/Brachyury" class="mw-redirect" title="Brachyury">TFT</a></li></ul></li> <li><a href="/wiki/Myelin_regulatory_factor" title="Myelin regulatory factor">MYRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.4) <a href="/wiki/MADS-box" title="MADS-box">MADS box</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mef2" title="Mef2">Mef2</a> <ul><li><a href="/wiki/Myocyte-specific_enhancer_factor_2A" title="Myocyte-specific enhancer factor 2A">A</a></li> <li><a href="/wiki/MEF2B" title="MEF2B">B</a></li> <li><a href="/wiki/MEF2C" title="MEF2C">C</a></li> <li><a href="/wiki/MEF2D" title="MEF2D">D</a></li></ul></li> <li><a href="/wiki/Serum_response_factor" title="Serum response factor">SRF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.6) <a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TATA-binding proteins</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TATA-binding_protein" title="TATA-binding protein">TBP</a></li> <li><a href="/wiki/TBPL1" title="TBPL1">TBPL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.7) <a href="/wiki/High-mobility_group" title="High-mobility group">High-mobility group</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BBX_(gene)" title="BBX (gene)">BBX</a></li> <li><a href="/wiki/HMG-box" title="HMG-box">HMGB</a> <ul><li><a href="/wiki/HMGB1" title="HMGB1">1</a></li> <li><a href="/wiki/HMGB2" title="HMGB2">2</a></li> <li><a href="/wiki/HMGB3" title="HMGB3">3</a></li> <li><a href="/wiki/HMGB4" title="HMGB4">4</a></li></ul></li> <li><a href="/wiki/HMGN" title="HMGN">HMGN</a> <ul><li><a href="/wiki/HMGN1" title="HMGN1">1</a></li> <li><a href="/wiki/HMGN2" title="HMGN2">2</a></li> <li><a href="/wiki/HMGN3" title="HMGN3">3</a></li> <li><a href="/wiki/HMGN4" title="HMGN4">4</a></li></ul></li> <li>HNF <ul><li><a href="/wiki/HNF1A" title="HNF1A">1A</a></li> <li><a href="/wiki/HNF1B" title="HNF1B">1B</a></li></ul></li> <li><a href="/wiki/SOX_gene_family" title="SOX gene family">SOX</a> <ul><li><a href="/wiki/SOX1" title="SOX1">1</a></li> <li><a href="/wiki/SOX2" title="SOX2">2</a></li> <li><a href="/wiki/SOX3" title="SOX3">3</a></li> <li><a href="/wiki/SOX4" title="SOX4">4</a></li> <li><a href="/wiki/SOX5" title="SOX5">5</a></li> <li><a href="/wiki/SOX6" title="SOX6">6</a></li> <li><a href="/wiki/SOX8" title="SOX8">8</a></li> <li><a href="/wiki/SOX9" title="SOX9">9</a></li> <li><a href="/wiki/SOX10" title="SOX10">10</a></li> <li><a href="/wiki/SOX11" title="SOX11">11</a></li> <li><a href="/wiki/SOX12" title="SOX12">12</a></li> <li><a href="/wiki/SOX13" title="SOX13">13</a></li> <li><a href="/wiki/SOX14" title="SOX14">14</a></li> <li><a href="/wiki/SOX15" title="SOX15">15</a></li> <li><a href="/wiki/SOX17" title="SOX17">17</a></li> <li><a href="/wiki/SOX18" title="SOX18">18</a></li> <li><a href="/wiki/SOX21" title="SOX21">21</a></li></ul></li> <li><a href="/wiki/Testis_determining_factor" class="mw-redirect" title="Testis determining factor">SRY</a></li> <li><a href="/wiki/Structure_specific_recognition_protein_1" title="Structure specific recognition protein 1">SSRP1</a></li> <li><a href="/wiki/TCF/LEF_family" title="TCF/LEF family">TCF/LEF</a> <ul><li>TCF <ul><li><a href="/wiki/TCF7" title="TCF7">1</a></li> <li><a href="/wiki/TCF3" title="TCF3">3</a></li> <li><a href="/wiki/TCF7L2" title="TCF7L2">4</a></li></ul></li> <li><a href="/wiki/Lymphoid_enhancer-binding_factor_1" title="Lymphoid enhancer-binding factor 1">LEF1</a></li></ul></li> <li>TOX <ul><li><a href="/wiki/TOX" title="TOX">1</a></li> <li><a href="/wiki/TOX2" title="TOX2">2</a></li> <li><a href="/wiki/TOX3" title="TOX3">3</a></li> <li><a href="/wiki/TOX4" title="TOX4">4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.9) Grainyhead</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TFCP2" title="TFCP2">TFCP2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.10) Cold-shock domain</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CSDA_(gene)" title="CSDA (gene)">CSDA</a></li> <li><a href="/wiki/Y_box_binding_protein_1" title="Y box binding protein 1">YBX1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(4.11) Runt</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Core_binding_factor" title="Core binding factor">CBF</a> <ul><li><a href="/wiki/CBFA2T2" title="CBFA2T2">CBFA2T2</a></li> <li><a href="/wiki/CBFA2T3" title="CBFA2T3">CBFA2T3</a></li> <li><a href="/wiki/RUNX1" title="RUNX1">RUNX1</a></li> <li><a href="/wiki/RUNX2" title="RUNX2">RUNX2</a></li> <li><a href="/wiki/RUNX3" title="RUNX3">RUNX3</a></li> <li><a href="/wiki/RUNX1T1" title="RUNX1T1">RUNX1T1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="(0)_Other_transcription_factors178" style="font-size:114%;margin:0 4em"> (0) Other transcription factors</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(0.2) HMGI(Y)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/HMGA" title="HMGA">HMGA</a> <ul><li><a href="/wiki/HMGA1" title="HMGA1">1</a></li> <li><a href="/wiki/HMGA2" title="HMGA2">2</a></li></ul></li> <li><a href="/wiki/HBP1" title="HBP1">HBP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(0.3) <a href="/wiki/Pocket_protein_family" title="Pocket protein family">Pocket domain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">Rb</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_1" title="Retinoblastoma-like protein 1">RBL1</a></li> <li><a href="/wiki/Retinoblastoma-like_protein_2" title="Retinoblastoma-like protein 2">RBL2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(0.5) <a href="/wiki/Apetala_2" title="Apetala 2">AP-2</a>/<a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a>-related factors</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0;background-color: AntiqueWhite;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Apetala_2" title="Apetala 2">Apetala 2</a></li> <li><a href="/wiki/Ethylene-responsive_element_binding_protein" title="Ethylene-responsive element binding protein">EREBP</a></li> <li><a href="/wiki/B3_domain" title="B3 domain">B3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:16em;text-align:left;">(0.6) Miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li>ARID <ul><li><a href="/wiki/ARID1A" title="ARID1A">1A</a></li> <li><a href="/wiki/ARID1B" title="ARID1B">1B</a></li> <li><a href="/wiki/ARID2" title="ARID2">2</a></li> <li><a href="/wiki/ARID3A" title="ARID3A">3A</a></li> <li><a href="/wiki/ARID3B" title="ARID3B">3B</a></li> <li><a href="/wiki/ARID4A" title="ARID4A">4A</a></li></ul></li> <li><a href="/wiki/Catabolite_activator_protein" title="Catabolite activator protein">CAP</a></li> <li>IFI <ul><li><a href="/wiki/IFI16" title="IFI16">16</a></li> <li><a href="/wiki/IFI35" title="IFI35">35</a></li></ul></li> <li><a href="/wiki/MLL_(gene)" class="mw-redirect" title="MLL (gene)">MLL</a> <ul><li><a href="/wiki/MLL2" class="mw-redirect" title="MLL2">2</a></li> <li><a href="/wiki/MLL3" class="mw-redirect" title="MLL3">3</a></li> <li><a href="/wiki/MLLT1" title="MLLT1">T1</a></li></ul></li> <li><a href="/wiki/MNDA" title="MNDA">MNDA</a></li> <li>NFY <ul><li><a href="/wiki/NFYA" title="NFYA">A</a></li> <li><a href="/wiki/NFYB" title="NFYB">B</a></li> <li><a href="/wiki/NFYC" title="NFYC">C</a></li></ul></li> <li><a href="/wiki/Rho_factor" title="Rho factor">Rho</a>/<a href="/wiki/Sigma_factor" title="Sigma factor">Sigma</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite"><div>see also <a href="/wiki/Template:Transcription_factor_and_coregulator_deficiencies" title="Template:Transcription factor and coregulator deficiencies">transcription factor/coregulator deficiencies</a></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Androgen_receptor_modulators801" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Androgen_receptor_modulators" title="Template:Androgen receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Androgen_receptor_modulators" title="Template talk:Androgen receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Androgen_receptor_modulators" title="Special:EditPage/Template:Androgen receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Androgen_receptor_modulators801" style="font-size:114%;margin:0 4em"><a class="mw-selflink selflink">Androgen receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a class="mw-selflink selflink"><abbr title="Androgen receptor">AR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Androgen receptor</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li>Testosterone derivatives: <a href="/wiki/4-Androstenediol" title="4-Androstenediol">4-Androstenediol</a></li> <li><a href="/wiki/4-Dehydroepiandrosterone" title="4-Dehydroepiandrosterone">4-Dehydroepiandrosterone (4-DHEA)</a></li> <li><a href="/wiki/4-Hydroxytestosterone" title="4-Hydroxytestosterone">4-Hydroxytestosterone</a></li> <li><a href="/w/index.php?title=4,17%CE%B1-Dimethyltestosterone&action=edit&redlink=1" class="new" title="4,17α-Dimethyltestosterone (page does not exist)">4,17α-Dimethyltestosterone</a></li> <li><a href="/wiki/5-Androstenedione" title="5-Androstenedione">5-Androstenedione</a></li> <li><a href="/wiki/11-Ketotestosterone" title="11-Ketotestosterone">11-Ketotestosterone</a></li> <li><a href="/wiki/11%CE%B2-Hydroxyandrostenedione" title="11β-Hydroxyandrostenedione">11β-Hydroxyandrostenedione</a></li> <li><a href="/wiki/Adrenosterone" title="Adrenosterone">Adrenosterone (11-ketoandrostenedione, 11-oxoandrostenedione)</a></li> <li><a href="/wiki/5-Androstenediol" class="mw-redirect" title="5-Androstenediol">Androstenediol (5-androstenediol)</a> <ul><li><a href="/wiki/Androstenediol_3%CE%B2-acetate" title="Androstenediol 3β-acetate">Androstenediol 3β-acetate</a></li> <li><a href="/wiki/Androstenediol_17%CE%B2-acetate" title="Androstenediol 17β-acetate">Androstenediol 17β-acetate</a></li> <li><a href="/wiki/Androstenediol_diacetate" title="Androstenediol diacetate">Androstenediol diacetate</a></li> <li><a href="/wiki/Androstenediol_dipropionate" title="Androstenediol dipropionate">Androstenediol dipropionate</a></li></ul></li> <li><a href="/wiki/4-Androstenedione" class="mw-redirect" title="4-Androstenedione">Androstenedione (4-androstenedione)</a></li> <li><a href="/wiki/Atamestane" title="Atamestane">Atamestane</a></li> <li><a href="/wiki/Boldenone" title="Boldenone">Boldenone</a> <ul><li><a href="/wiki/Boldenone_undecylenate" title="Boldenone undecylenate">Boldenone undecylenate</a></li></ul></li> <li><a href="/wiki/Boldione" title="Boldione">Boldione (1,4-androstadienedione)</a></li> <li><a href="/wiki/Clostebol" title="Clostebol">Clostebol</a> <ul><li><a href="/wiki/Clostebol_acetate" title="Clostebol acetate">Clostebol acetate</a></li> <li><a href="/wiki/Clostebol_caproate" title="Clostebol caproate">Clostebol caproate</a></li> <li><a href="/wiki/Clostebol_propionate" title="Clostebol propionate">Clostebol propionate</a></li></ul></li> <li><a href="/wiki/Cloxotestosterone" title="Cloxotestosterone">Cloxotestosterone</a> <ul><li><a href="/wiki/Cloxotestosterone_acetate" title="Cloxotestosterone acetate">Cloxotestosterone acetate</a></li></ul></li> <li><a href="/wiki/Dehydroandrosterone" title="Dehydroandrosterone">Dehydroandrosterone</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA (androstenolone, prasterone; 5-DHEA)</a> <ul><li><a href="/wiki/Prasterone_enanthate" title="Prasterone enanthate">DHEA enanthate (prasterone enanthate)</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA sulfate</a></li></ul></li> <li><a href="/wiki/Exemestane" title="Exemestane">Exemestane</a></li> <li><a href="/wiki/Formestane" title="Formestane">Formestane</a></li> <li><a href="/wiki/Plomestane" title="Plomestane">Plomestane</a></li> <li><a href="/wiki/Quinbolone" title="Quinbolone">Quinbolone</a></li> <li><a href="/wiki/Silandrone" title="Silandrone">Silandrone</a></li> <li><a href="/wiki/Testosterone_(medication)" title="Testosterone (medication)">Testosterone</a># (<a href="/wiki/Testosterone/dutasteride" title="Testosterone/dutasteride">+dutasteride</a>) <ul><li><a href="/wiki/List_of_androgen_esters#Testosterone_esters" title="List of androgen esters">Testosterone esters</a></li> <li><a href="/wiki/Polytestosterone_phloretin_phosphate" title="Polytestosterone phloretin phosphate">Polytestosterone phloretin phosphate</a></li></ul></li></ul> <ul><li>5α-Dihydrotestosterone derivatives: <a href="/wiki/1-Androstenediol" title="1-Androstenediol">1-Androstenediol</a></li> <li><a href="/wiki/1-Androstenedione" title="1-Androstenedione">1-Androstenedione</a></li> <li><a href="/wiki/1-Androsterone" title="1-Androsterone">1-Androsterone (1-andro, 1-DHEA)</a></li> <li><a href="/wiki/1-Testosterone" title="1-Testosterone">1-Testosterone</a></li> <li><a href="/wiki/3%CE%B1-Androstanediol" title="3α-Androstanediol">3α-Androstanediol</a></li> <li><a href="/wiki/5%CE%B1-Androst-2-en-17-one" class="mw-redirect" title="5α-Androst-2-en-17-one">5α-Androst-2-en-17-one</a></li> <li><a href="/wiki/7%CE%B2-Hydroxyepiandrosterone" title="7β-Hydroxyepiandrosterone">7β-Hydroxyepiandrosterone</a></li> <li><a href="/wiki/11-Ketodihydrotestosterone" title="11-Ketodihydrotestosterone">11-Ketodihydrotestosterone</a></li> <li><a href="/wiki/Androsterone" title="Androsterone">Androsterone</a></li> <li><a href="/wiki/Bolazine" title="Bolazine">Bolazine</a> <ul><li><a href="/wiki/Bolazine_capronate" title="Bolazine capronate">Bolazine capronate</a></li></ul></li> <li><a href="/w/index.php?title=Dihydroethyltestosterone&action=edit&redlink=1" class="new" title="Dihydroethyltestosterone (page does not exist)">Dihydroethyltestosterone</a></li> <li><a href="/wiki/Dihydrofluoxymesterone" title="Dihydrofluoxymesterone">Dihydrofluoxymesterone</a></li> <li><a href="/w/index.php?title=Dihydromethylandrostenediol&action=edit&redlink=1" class="new" title="Dihydromethylandrostenediol (page does not exist)">Dihydromethylandrostenediol</a></li> <li><a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">Dihydrotestosterone (DHT)</a> (<a href="/wiki/Androstanolone" title="Androstanolone">androstanolone, stanolone</a>) <ul><li><a href="/wiki/List_of_androgen_esters#Dihydrotestosterone_esters" title="List of androgen esters">Dihydrotestosterone esters</a></li></ul></li> <li><a href="/wiki/Drostanolone" title="Drostanolone">Drostanolone</a> <ul><li><a href="/wiki/Drostanolone_propionate" title="Drostanolone propionate">Drostanolone propionate</a></li></ul></li> <li><a href="/wiki/Epiandrosterone" title="Epiandrosterone">Epiandrosterone</a></li> <li><a href="/wiki/Epitiostanol" title="Epitiostanol">Epitiostanol</a></li> <li><a href="/wiki/Mepitiostane" title="Mepitiostane">Mepitiostane</a></li> <li><a href="/wiki/Mesabolone" title="Mesabolone">Mesabolone</a></li> <li><a href="/wiki/Mesterolone" title="Mesterolone">Mesterolone</a> <ul><li><a href="/wiki/Mesterolone_cipionate" title="Mesterolone cipionate">Mesterolone cipionate</a></li></ul></li> <li><a href="/wiki/Methyldiazinol" title="Methyldiazinol">Methyldiazinol</a></li> <li><a href="/wiki/Nisterime" title="Nisterime">Nisterime</a> <ul><li><a href="/wiki/Nisterime_acetate" title="Nisterime acetate">Nisterime acetate</a></li></ul></li> <li><a href="/wiki/Prostanozol" title="Prostanozol">Prostanozol</a></li> <li><a href="/wiki/Stenbolone" title="Stenbolone">Stenbolone</a> <ul><li><a href="/wiki/Stenbolone_acetate" title="Stenbolone acetate">Stenbolone acetate</a></li></ul></li> <li><a href="/wiki/Testifenon" title="Testifenon">Testifenon (testiphenon, testiphenone)</a></li></ul> <ul><li>19-Nortestosterone derivatives: <a href="/wiki/7%CE%B1-Methyl-19-norandrostenedione" title="7α-Methyl-19-norandrostenedione">7α-Methyl-19-norandrostenedione (MENT dione, trestione)</a></li> <li><a href="/wiki/11%CE%B2-Methyl-19-nortestosterone" title="11β-Methyl-19-nortestosterone">11β-Methyl-19-nortestosterone</a> <ul><li><a href="/wiki/11%CE%B2-Methyl-19-nortestosterone_dodecylcarbonate" title="11β-Methyl-19-nortestosterone dodecylcarbonate">11β-Methyl-19-nortestosterone dodecylcarbonate</a></li></ul></li> <li><a href="/wiki/19-Nor-5-androstenediol" title="19-Nor-5-androstenediol">19-Nor-5-androstenediol</a></li> <li><a href="/wiki/19-Nor-5-androstenedione" title="19-Nor-5-androstenedione">19-Nor-5-androstenedione</a></li> <li><a href="/wiki/19-Nordehydroepiandrosterone" title="19-Nordehydroepiandrosterone">19-Nordehydroepiandrosterone</a></li> <li><a href="/wiki/Bolandiol" title="Bolandiol">Bolandiol</a> <ul><li><a href="/wiki/Bolandiol_dipropionate" title="Bolandiol dipropionate">Bolandiol dipropionate</a></li></ul></li> <li><a href="/wiki/Bolandione" title="Bolandione">Bolandione (19-nor-4-androstenedione)</a></li> <li><a href="/wiki/Bolmantalate" title="Bolmantalate">Bolmantalate (nandrolone adamantoate)</a></li> <li><a href="/wiki/Dienedione" title="Dienedione">Dienedione</a></li> <li><a href="/wiki/Dienolone" title="Dienolone">Dienolone</a></li> <li><a href="/wiki/Dimethandrolone" title="Dimethandrolone">Dimethandrolone</a> <ul><li><a href="/wiki/Dimethandrolone_buciclate" title="Dimethandrolone buciclate">Dimethandrolone buciclate</a></li> <li><a href="/wiki/Dimethandrolone_dodecylcarbonate" title="Dimethandrolone dodecylcarbonate">Dimethandrolone dodecylcarbonate</a></li> <li><a href="/wiki/Dimethandrolone_undecanoate" title="Dimethandrolone undecanoate">Dimethandrolone undecanoate</a></li></ul></li> <li><a href="/wiki/LS-1727" title="LS-1727">LS-1727 (nandrolone 17β-N-(2-chloroethyl)-N-nitrosocarbamate)</a></li> <li><a href="/wiki/Methoxydienone" title="Methoxydienone">Methoxydienone (methoxygonadiene)</a></li> <li><a href="/wiki/Nandrolone" title="Nandrolone">Nandrolone</a> <ul><li><a href="/wiki/List_of_androgen_esters#Nandrolone_esters" title="List of androgen esters">Nandrolone esters</a></li></ul></li> <li><a href="/wiki/Norclostebol" title="Norclostebol">Norclostebol</a> <ul><li><a href="/wiki/Norclostebol_acetate" title="Norclostebol acetate">Norclostebol acetate</a></li></ul></li> <li><a href="/wiki/Normethandrone" title="Normethandrone">Normethandrone (methylestrenolone, normethisterone)</a></li> <li><a href="/wiki/Oxabolone" title="Oxabolone">Oxabolone</a> <ul><li><a href="/wiki/Oxabolone_cipionate" title="Oxabolone cipionate">Oxabolone cipionate (oxabolone cypionate)</a></li></ul></li> <li><a href="/wiki/Trenbolone" title="Trenbolone">Trenbolone</a> <ul><li><a href="/wiki/Trenbolone_acetate" title="Trenbolone acetate">Trenbolone acetate</a></li> <li><a href="/wiki/Trenbolone_enanthate" title="Trenbolone enanthate">Trenbolone enanthate</a></li> <li><a href="/wiki/Trenbolone_hexahydrobenzylcarbonate" title="Trenbolone hexahydrobenzylcarbonate">Trenbolone hexahydrobenzylcarbonate</a></li> <li><a href="/wiki/Trenbolone_undecanoate" title="Trenbolone undecanoate">Trenbolone undecanoate</a></li></ul></li> <li><a href="/wiki/Trendione" title="Trendione">Trendione</a></li> <li><a href="/wiki/Trestolone" title="Trestolone">Trestolone (MENT)</a> <ul><li><a href="/wiki/Trestolone_acetate" title="Trestolone acetate">Trestolone acetate</a></li> <li><a href="/wiki/Trestolone_enanthate" title="Trestolone enanthate">Trestolone enanthate</a></li></ul></li></ul> <ul><li>5α-Dihydro-19-nortestosterone derivatives: <a href="/wiki/5%CE%B1-Dihydronandrolone" title="5α-Dihydronandrolone">5α-Dihydronandrolone</a></li> <li><a href="/w/index.php?title=5%CE%B1-Dihydrotrestolone&action=edit&redlink=1" class="new" title="5α-Dihydrotrestolone (page does not exist)">5α-Dihydrotrestolone</a></li> <li><a href="/wiki/19-Norandrosterone" title="19-Norandrosterone">19-Norandrosterone</a></li></ul> <ul><li>17α-Alkylated testosterone derivatives: <a href="/wiki/Bolasterone" title="Bolasterone">Bolasterone</a></li> <li><a href="/wiki/Calusterone" title="Calusterone">Calusterone</a></li> <li><a href="/wiki/Chlorodehydromethylandrostenediol" title="Chlorodehydromethylandrostenediol">Chlorodehydromethylandrostenediol (CDMA)</a></li> <li><a href="/wiki/Chlorodehydromethyltestosterone" title="Chlorodehydromethyltestosterone">Chlorodehydromethyltestosterone (CDMT)</a></li> <li><a href="/wiki/Chloromethylandrostenediol" title="Chloromethylandrostenediol">Chloromethylandrostenediol (CMA)</a></li> <li><a href="/wiki/Enestebol" title="Enestebol">Enestebol</a></li> <li><a href="/wiki/Ethyltestosterone" title="Ethyltestosterone">Ethyltestosterone</a></li> <li><a href="/wiki/Fluoxymesterone" title="Fluoxymesterone">Fluoxymesterone</a></li> <li><a href="/wiki/Formebolone" title="Formebolone">Formebolone</a></li> <li><a href="/wiki/Hydroxystenozole" title="Hydroxystenozole">Hydroxystenozole</a></li> <li><a href="/wiki/Metandienone" title="Metandienone">Metandienone (methandrostenolone)</a></li> <li><a href="/wiki/Methandriol" title="Methandriol">Methandriol (methylandrostenediol)</a> <ul><li><a href="/wiki/Methandriol_bisenanthoyl_acetate" title="Methandriol bisenanthoyl acetate">Methandriol bisenanthoyl acetate</a></li> <li><a href="/wiki/Methandriol_diacetate" title="Methandriol diacetate">Methandriol diacetate</a></li> <li><a href="/wiki/Methandriol_dipropionate" title="Methandriol dipropionate">Methandriol dipropionate</a></li> <li><a href="/wiki/Methandriol_propionate" title="Methandriol propionate">Methandriol propionate</a></li></ul></li> <li><a href="/wiki/Methylclostebol" title="Methylclostebol">Methylclostebol (chloromethyltestosterone)</a></li> <li><a href="/wiki/Methyltestosterone" title="Methyltestosterone">Methyltestosterone</a> (<a href="/wiki/Esterified_estrogens/methyltestosterone" title="Esterified estrogens/methyltestosterone">+esterified estrogens</a>) <ul><li><a href="/wiki/Methyltestosterone_3-hexyl_ether" title="Methyltestosterone 3-hexyl ether">Methyltestosterone 3-hexyl ether</a></li></ul></li> <li><a href="/wiki/Oxymesterone" title="Oxymesterone">Oxymesterone</a></li> <li><a href="/wiki/Penmesterol" title="Penmesterol">Penmesterol</a></li> <li><a href="/wiki/Tiomesterone" title="Tiomesterone">Tiomesterone</a></li></ul> <ul><li>17α-Alkylated 5α-dihydrotestosterone derivatives: <a href="/wiki/Androisoxazole" title="Androisoxazole">Androisoxazole</a></li> <li><a href="/wiki/Desoxymethyltestosterone" title="Desoxymethyltestosterone">Desoxymethyltestosterone</a></li> <li><a href="/wiki/Furazabol" title="Furazabol">Furazabol</a></li> <li><a href="/wiki/Mebolazine" title="Mebolazine">Mebolazine (dimethazine)</a></li> <li><a href="/wiki/Mestanolone" title="Mestanolone">Mestanolone</a></li> <li><a href="/wiki/Metenolone" title="Metenolone">Metenolone</a> <ul><li><a href="/wiki/Metenolone_acetate" title="Metenolone acetate">Metenolone acetate</a></li> <li><a href="/wiki/Metenolone_enanthate" title="Metenolone enanthate">Metenolone enanthate</a></li></ul></li> <li><a href="/wiki/Methasterone" title="Methasterone">Methasterone</a></li> <li><a href="/wiki/Methyl-1-testosterone" title="Methyl-1-testosterone">Methyl-1-testosterone</a></li> <li><a href="/wiki/Methylepitiostanol" title="Methylepitiostanol">Methylepitiostanol</a></li> <li><a href="/wiki/Methylstenbolone" title="Methylstenbolone">Methylstenbolone</a></li> <li><a href="/wiki/Oxandrolone" title="Oxandrolone">Oxandrolone</a></li> <li><a href="/wiki/Oxymetholone" title="Oxymetholone">Oxymetholone</a></li> <li><a href="/wiki/Stanozolol" title="Stanozolol">Stanozolol</a></li></ul> <ul><li>17α-Alkylated 19-nortestosterone derivatives: <a href="/wiki/Bolenol" title="Bolenol">Bolenol</a></li> <li><a href="/wiki/Dimethyldienolone" title="Dimethyldienolone">Dimethyldienolone</a></li> <li><a href="/wiki/Dimethyltrienolone" title="Dimethyltrienolone">Dimethyltrienolone</a></li> <li><a href="/wiki/Ethyldienolone" title="Ethyldienolone">Ethyldienolone</a></li> <li><a href="/wiki/Ethylestrenol" title="Ethylestrenol">Ethylestrenol</a></li> <li><a href="/wiki/Methyldienolone" title="Methyldienolone">Methyldienolone</a></li> <li><a href="/wiki/Methylhydroxynandrolone" title="Methylhydroxynandrolone">Methylhydroxynandrolone (MOHN, MHN)</a></li> <li><a href="/wiki/Metribolone" title="Metribolone">Metribolone</a></li> <li><a href="/wiki/Mibolerone" title="Mibolerone">Mibolerone</a></li> <li><a href="/wiki/Norboletone" title="Norboletone">Norboletone</a></li> <li><a href="/wiki/Norethandrolone" title="Norethandrolone">Norethandrolone</a></li> <li><a href="/wiki/Propetandrol" title="Propetandrol">Propetandrol</a></li> <li><a href="/wiki/RU-2309" title="RU-2309">RU-2309</a></li> <li><a href="/wiki/Tetrahydrogestrinone" title="Tetrahydrogestrinone">Tetrahydrogestrinone</a></li></ul> <ul><li>17α-Alkylated 5α-dihydro-19-nortestosterone derivatives: <a href="/wiki/5%CE%B1-Dihydronorethandrolone" title="5α-Dihydronorethandrolone">5α-Dihydronorethandrolone</a></li> <li><a href="/wiki/5%CE%B1-Dihydronormethandrone" title="5α-Dihydronormethandrone">5α-Dihydronormethandrone</a></li></ul> <ul><li>17α-Vinyltestosterone derivatives: <a href="/wiki/Norvinisterone" title="Norvinisterone">Norvinisterone (vinylnortestosterone)</a></li></ul> <ul><li>17α-Vinyl-19-nortestosterone derivatives: <a href="/wiki/Vinyltestosterone" title="Vinyltestosterone">Vinyltestosterone</a></li></ul> <ul><li>17α-Ethynyltestosterone derivatives: <a href="/wiki/Danazol" title="Danazol">Danazol</a></li> <li><a href="/wiki/Ethinylandrostenediol" title="Ethinylandrostenediol">Ethinylandrostenediol</a> <ul><li><a href="/wiki/Ethandrostate" title="Ethandrostate">Ethandrostate</a></li></ul></li> <li><a href="/wiki/Ethisterone" title="Ethisterone">Ethisterone (ethynyltestosterone)</a></li></ul> <ul><li>5α-Dihydro-17α-ethynyltestosterone derivatives: <a href="/wiki/17%CE%B1-Ethynyl-3%CE%B1-androstanediol" title="17α-Ethynyl-3α-androstanediol">17α-Ethynyl-3α-androstanediol</a></li> <li><a href="/wiki/17%CE%B1-Ethynyl-3%CE%B2-androstanediol" title="17α-Ethynyl-3β-androstanediol">17α-Ethynyl-3β-androstanediol</a></li> <li><a href="/wiki/Dihydroethisterone" class="mw-redirect" title="Dihydroethisterone">Dihydroethisterone</a></li></ul> <ul><li>17α-Ethynyl-19-nortestosterone derivatives: <a href="/wiki/%CE%944-Tibolone" title="Δ4-Tibolone">Δ4-Tibolone</a></li> <li><a href="/wiki/Desogestrel" title="Desogestrel">Desogestrel</a></li> <li><a href="/wiki/Etonogestrel" title="Etonogestrel">Etonogestrel</a></li> <li><a href="/wiki/Etynodiol" title="Etynodiol">Etynodiol</a> <ul><li><a href="/wiki/Etynodiol_diacetate" title="Etynodiol diacetate">Etynodiol diacetate</a></li></ul></li> <li><a href="/wiki/Gestodene" title="Gestodene">Gestodene</a></li> <li><a href="/wiki/Gestrinone" title="Gestrinone">Gestrinone</a></li> <li><a href="/wiki/Levonorgestrel" title="Levonorgestrel">Levonorgestrel</a></li> <li><a href="/wiki/Levonorgestrel_ester" class="mw-redirect" title="Levonorgestrel ester">Levonorgestrel esters</a> (e.g., <a href="/wiki/Levonorgestrel_butanoate" title="Levonorgestrel butanoate">levonorgestrel butanoate</a>)</li> <li><a href="/wiki/Lynestrenol" title="Lynestrenol">Lynestrenol</a> <ul><li><a href="/wiki/Lynestrenol_phenylpropionate" title="Lynestrenol phenylpropionate">Lynestrenol phenylpropionate</a></li></ul></li> <li><a href="/wiki/Norethisterone" title="Norethisterone">Norethisterone</a></li> <li><a href="/wiki/Norethisterone_ester" class="mw-redirect" title="Norethisterone ester">Norethisterone esters</a> (e.g., <a href="/wiki/Norethisterone_acetate" title="Norethisterone acetate">norethisterone acetate</a>, <a href="/wiki/Norethisterone_enanthate" title="Norethisterone enanthate">norethisterone enanthate</a>)</li> <li><a href="/wiki/Norgestrel" title="Norgestrel">Norgestrel</a></li> <li><a href="/wiki/Norgestrienone" title="Norgestrienone">Norgestrienone</a></li> <li><a href="/wiki/Quingestanol" title="Quingestanol">Quingestanol</a> <ul><li><a href="/wiki/Quingestanol_acetate" title="Quingestanol acetate">Quingestanol acetate</a></li></ul></li> <li><a href="/wiki/Tibolone" title="Tibolone">Tibolone</a></li></ul> <ul><li>5α-Dihydro-17α-ethynyl-19-nortestosterone derivatives: <a href="/wiki/5%CE%B1-Dihydrolevonorgestrel" title="5α-Dihydrolevonorgestrel">5α-Dihydrolevonorgestrel</a></li> <li><a href="/wiki/5%CE%B1-Dihydronorethisterone" title="5α-Dihydronorethisterone">5α-Dihydronorethisterone</a></li></ul> <ul><li>Progesterone derivatives: <a href="/wiki/6%CE%B1-Methylprogesterone" title="6α-Methylprogesterone">6α-Methylprogesterone</a></li> <li><a href="/wiki/Medroxyprogesterone_acetate" title="Medroxyprogesterone acetate">Medroxyprogesterone acetate</a></li> <li><a href="/wiki/Megestrol_acetate" title="Megestrol acetate">Megestrol acetate</a></li></ul> <ul><li>Others/unsorted: <a href="/wiki/3-Keto-5%CE%B1-abiraterone" title="3-Keto-5α-abiraterone">3-Keto-5α-abiraterone</a></li> <li><a href="/wiki/5%CE%B1-Androstane" class="mw-redirect" title="5α-Androstane">5α-Androstane</a></li> <li><a href="/wiki/Alternariol" title="Alternariol">Alternariol</a></li> <li><a href="/wiki/Cl-4AS-1" title="Cl-4AS-1">Cl-4AS-1</a></li> <li><a href="/wiki/Drupanol" title="Drupanol">Drupanol</a></li> <li><a href="/wiki/Trilostane" title="Trilostane">Trilostane</a></li> <li><a href="/wiki/ZM-182345" title="ZM-182345">ZM-182345</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center"><a href="/wiki/Selective_androgen_receptor_modulator" title="Selective androgen receptor modulator"><abbr title="Selective androgen receptor modulator">SARMs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Selective androgen receptor modulator</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li>Nonsteroidal: <a href="/w/index.php?title=198RL26&action=edit&redlink=1" class="new" title="198RL26 (page does not exist)">198RL26</a></li> <li><a href="/wiki/ACP-105" title="ACP-105">ACP-105</a></li> <li><a href="/wiki/AC-262,536" title="AC-262,536">AC-262,536</a></li> <li><a href="/wiki/Acetothiolutamide" title="Acetothiolutamide">Acetothiolutamide</a></li> <li><a href="/wiki/Acetoxolutamide" title="Acetoxolutamide">Acetoxolutamide</a></li> <li><a href="/wiki/Andarine" title="Andarine">Andarine (acetamidoxolutamide, androxolutamide, GTx-007, S-4)</a></li> <li><a href="/wiki/BMS-564,929" title="BMS-564,929">BMS-564,929</a></li> <li><a href="/w/index.php?title=DTIB&action=edit&redlink=1" class="new" title="DTIB (page does not exist)">DTIB</a></li> <li><a href="/wiki/Enobosarm" title="Enobosarm">Enobosarm (ostarine, MK-2866, GTx-024, S-22)</a></li> <li><a href="/w/index.php?title=FTBU-1&action=edit&redlink=1" class="new" title="FTBU-1 (page does not exist)">FTBU-1</a></li> <li><a href="/wiki/GLPG-0492" title="GLPG-0492">GLPG-0492</a></li> <li><a href="/wiki/GSK2881078" title="GSK2881078">GSK2881078</a></li> <li><a href="/wiki/GSK-4336A" title="GSK-4336A">GSK-4336A</a></li> <li><a href="/w/index.php?title=GSK-8698&action=edit&redlink=1" class="new" title="GSK-8698 (page does not exist)">GSK-8698</a></li> <li><a href="/wiki/LG121071" title="LG121071">LG121071 (LGD-121071)</a></li> <li><a href="/wiki/LGD-2226" title="LGD-2226">LGD-2226</a></li> <li><a href="/wiki/LGD-2941" title="LGD-2941">LGD-2941 (LGD-122941)</a></li> <li><a href="/wiki/LGD-3303" title="LGD-3303">LGD-3303</a></li> <li><a href="/wiki/LGD-4033" class="mw-redirect" title="LGD-4033">LGD-4033</a></li> <li><a href="/wiki/LY305" title="LY305">LY305</a></li> <li><a href="/wiki/JNJ-26146900" title="JNJ-26146900">JNJ-26146900</a></li> <li><a href="/wiki/JNJ-28330835" title="JNJ-28330835">JNJ-28330835</a></li> <li><a href="/wiki/JNJ-37654032" title="JNJ-37654032">JNJ-37654032</a></li> <li><a href="/wiki/OPK-88004" title="OPK-88004">OPK-88004 (LY-2452473, TT-701)</a></li> <li><a href="/w/index.php?title=ORM-11984&action=edit&redlink=1" class="new" title="ORM-11984 (page does not exist)">ORM-11984</a></li> <li><a href="/wiki/PF-06260414" title="PF-06260414">PF-06260414</a></li> <li><a href="/w/index.php?title=R-1_(drug)&action=edit&redlink=1" class="new" title="R-1 (drug) (page does not exist)">R-1</a></li> <li><a href="/wiki/RU-59063" title="RU-59063">RU-59063</a></li> <li><a href="/w/index.php?title=S-1_(drug)&action=edit&redlink=1" class="new" title="S-1 (drug) (page does not exist)">S-1</a></li> <li><a href="/wiki/S-23_(drug)" title="S-23 (drug)">S-23</a></li> <li><a href="/wiki/S-40503" title="S-40503">S-40503</a></li> <li><a href="/w/index.php?title=S-101479&action=edit&redlink=1" class="new" title="S-101479 (page does not exist)">S-101479</a></li> <li><a href="/wiki/Vosilasarm" title="Vosilasarm">Vosilasarm</a></li></ul> <ul><li>Steroidal: <a href="/w/index.php?title=EM-9017&action=edit&redlink=1" class="new" title="EM-9017 (page does not exist)">EM-9017</a></li> <li><a href="/wiki/MK-0773" title="MK-0773">MK-0773</a></li> <li><a href="/wiki/TFM-4AS-1" title="TFM-4AS-1">TFM-4AS-1</a></li> <li><a href="/wiki/YK-11" title="YK-11">YK-11</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li>Steroidal: <a href="/wiki/7%CE%B1-Thioprogesterone" title="7α-Thioprogesterone">7α-Thioprogesterone</a></li> <li><a href="/wiki/7%CE%B1-Thiospironolactone" title="7α-Thiospironolactone">7α-Thiospironolactone</a></li> <li><a href="/wiki/7%CE%B1-Thiomethylspironolactone" title="7α-Thiomethylspironolactone">7α-Thiomethylspironolactone</a></li> <li><a href="/wiki/11%CE%B1-Hydroxyprogesterone" title="11α-Hydroxyprogesterone">11α-Hydroxyprogesterone</a></li> <li><a href="/wiki/15%CE%B2-Hydroxycyproterone_acetate" title="15β-Hydroxycyproterone acetate">15β-Hydroxycyproterone acetate</a></li> <li><a href="/wiki/Abiraterone" class="mw-redirect" title="Abiraterone">Abiraterone</a></li> <li><a href="/wiki/Abiraterone_acetate" title="Abiraterone acetate">Abiraterone acetate</a></li> <li><a href="/wiki/Allyltestosterone" title="Allyltestosterone">Allyltestosterone</a></li> <li><a href="/wiki/Benorterone" title="Benorterone">Benorterone</a></li> <li><a href="/wiki/BOMT" title="BOMT">BOMT</a></li> <li><a href="/wiki/Canrenoic_acid" title="Canrenoic acid">Canrenoic acid</a></li> <li><a href="/wiki/Canrenone" title="Canrenone">Canrenone</a></li> <li><a href="/wiki/Chlormadinone_acetate" title="Chlormadinone acetate">Chlormadinone acetate</a></li> <li><a href="/wiki/Clascoterone" title="Clascoterone">Clascoterone</a></li> <li><a href="/wiki/Clometerone" title="Clometerone">Clometerone</a></li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/Cyproterone" title="Cyproterone">Cyproterone</a></li> <li><a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">Cyproterone acetate</a></li> <li><a href="/wiki/Delanterone" title="Delanterone">Delanterone</a></li> <li><a href="/wiki/Delmadinone_acetate" title="Delmadinone acetate">Delmadinone acetate</a></li> <li><a href="/wiki/Dicirenone" title="Dicirenone">Dicirenone</a></li> <li><a href="/wiki/Dienogest" title="Dienogest">Dienogest</a></li> <li><a href="/wiki/Drospirenone" title="Drospirenone">Drospirenone</a></li> <li><a href="/wiki/DU-41165" title="DU-41165">DU-41165</a></li> <li><a href="/wiki/Edogestrone" title="Edogestrone">Edogestrone</a></li> <li><a href="/w/index.php?title=EM-4350&action=edit&redlink=1" class="new" title="EM-4350 (page does not exist)">EM-4350</a></li> <li><a href="/wiki/EM-5854" title="EM-5854">EM-5854</a></li> <li><a href="/w/index.php?title=EM-5855&action=edit&redlink=1" class="new" title="EM-5855 (page does not exist)">EM-5855</a></li> <li><a href="/w/index.php?title=EM-6537&action=edit&redlink=1" class="new" title="EM-6537 (page does not exist)">EM-6537</a></li> <li><a href="/wiki/Epitestosterone" title="Epitestosterone">Epitestosterone</a></li> <li><a href="/wiki/Galeterone" title="Galeterone">Galeterone</a></li> <li><a href="/wiki/Guggulsterone" title="Guggulsterone">Guggulsterone</a></li> <li><a href="/w/index.php?title=Ludaterone&action=edit&redlink=1" class="new" title="Ludaterone (page does not exist)">Ludaterone</a></li> <li><a href="/wiki/Medrogestone" title="Medrogestone">Medrogestone</a></li> <li><a href="/wiki/Megestrol_acetate" title="Megestrol acetate">Megestrol acetate</a></li> <li><a href="/wiki/Mespirenone" title="Mespirenone">Mespirenone</a></li> <li><a href="/wiki/Metogest" title="Metogest">Metogest</a></li> <li><a href="/wiki/Mexrenone" title="Mexrenone">Mexrenone</a></li> <li><a href="/wiki/Mifepristone" title="Mifepristone">Mifepristone</a></li> <li><a href="/wiki/Nomegestrol_acetate" title="Nomegestrol acetate">Nomegestrol acetate</a></li> <li><a href="/wiki/Nordinone" title="Nordinone">Nordinone</a></li> <li><a href="/wiki/Osaterone" title="Osaterone">Osaterone</a></li> <li><a href="/wiki/Osaterone_acetate" title="Osaterone acetate">Osaterone acetate</a></li> <li><a href="/wiki/Oxendolone" title="Oxendolone">Oxendolone</a></li> <li><a href="/wiki/Potassium_canrenoate" title="Potassium canrenoate">Potassium canrenoate</a></li> <li><a href="/wiki/Promegestone" title="Promegestone">Promegestone</a></li> <li><a href="/wiki/Prorenone" title="Prorenone">Prorenone</a></li> <li><a href="/wiki/Rosterolone" title="Rosterolone">Rosterolone</a></li> <li><a href="/w/index.php?title=RU-15328&action=edit&redlink=1" class="new" title="RU-15328 (page does not exist)">RU-15328</a></li> <li><a href="/wiki/SC-5233" title="SC-5233">SC-5233 (spirolactone)</a></li> <li><a href="/wiki/Spironolactone" title="Spironolactone">Spironolactone</a></li> <li><a href="/wiki/Spirorenone" title="Spirorenone">Spirorenone</a></li> <li><a href="/wiki/Spiroxasone" title="Spiroxasone">Spiroxasone</a></li> <li><a href="/wiki/Topterone" title="Topterone">Topterone</a></li> <li><a href="/wiki/Trimegestone" title="Trimegestone">Trimegestone</a></li> <li><a href="/wiki/Trimethyltrienolone" title="Trimethyltrienolone">Trimethyltrienolone (R-2956)</a></li> <li><a href="/wiki/Zanoterone" title="Zanoterone">Zanoterone</a></li></ul> <ul><li>Nonsteroidal: <a href="/wiki/5N-Bicalutamide" title="5N-Bicalutamide">5N-Bicalutamide</a></li> <li><a href="/wiki/AA560" title="AA560">AA560</a></li> <li><a href="/w/index.php?title=Antarlide&action=edit&redlink=1" class="new" title="Antarlide (page does not exist)">Antarlides</a></li> <li><a href="/w/index.php?title=Arabilin&action=edit&redlink=1" class="new" title="Arabilin (page does not exist)">Arabilin</a></li> <li><a href="/wiki/Apalutamide" title="Apalutamide">Apalutamide</a></li> <li><a href="/wiki/Atraric_acid" title="Atraric acid">Atraric acid</a></li> <li><a href="/w/index.php?title=AZD-3514&action=edit&redlink=1" class="new" title="AZD-3514 (page does not exist)">AZD-3514</a></li> <li><a href="/wiki/Bakuchiol" title="Bakuchiol">Bakuchiol</a></li> <li><a href="/wiki/Bavdegalutamide" title="Bavdegalutamide">Bavdegalutamide</a></li> <li><a href="/w/index.php?title=BAY-1024767&action=edit&redlink=1" class="new" title="BAY-1024767 (page does not exist)">BAY-1024767</a></li> <li><a href="/wiki/Bicalutamide" title="Bicalutamide">Bicalutamide</a></li> <li><a href="/wiki/Bisphenol" title="Bisphenol">Bisphenols</a> (e.g., <a href="/wiki/Bisphenol_A_diglycidyl_ether" title="Bisphenol A diglycidyl ether">BADGE</a>, <a href="/w/index.php?title=Bisphenol_F_diglycidyl_ether&action=edit&redlink=1" class="new" title="Bisphenol F diglycidyl ether (page does not exist)">BFDGE</a>, <a href="/wiki/Bisphenol_A" title="Bisphenol A">bisphenol A</a>, <a href="/wiki/Bisphenol_F" title="Bisphenol F">bisphenol F</a>, <a href="/wiki/Bisphenol_S" title="Bisphenol S">bisphenol S</a>)</li> <li><a href="/w/index.php?title=BMS-501949&action=edit&redlink=1" class="new" title="BMS-501949 (page does not exist)">BMS-501949</a></li> <li><a href="/w/index.php?title=BMS-570511&action=edit&redlink=1" class="new" title="BMS-570511 (page does not exist)">BMS-570511</a></li> <li><a href="/wiki/BMS-641988" title="BMS-641988">BMS-641988</a></li> <li><a href="/w/index.php?title=CH5137291&action=edit&redlink=1" class="new" title="CH5137291 (page does not exist)">CH5137291</a></li> <li><a href="/wiki/Cimetidine" title="Cimetidine">Cimetidine</a></li> <li><a href="/wiki/Cioteronel" title="Cioteronel">Cioteronel</a></li> <li><a href="/wiki/Cyanonilutamide" title="Cyanonilutamide">Cyanonilutamide</a></li> <li><a href="/wiki/Darolutamide" title="Darolutamide">Darolutamide</a></li> <li><a href="/wiki/DDT" title="DDT">DDT</a> (via metabolite <a href="/wiki/Dichlorodiphenyldichloroethylene" title="Dichlorodiphenyldichloroethylene">p,p’-DDE</a>)</li> <li><a href="/wiki/Dieldrin" title="Dieldrin">Dieldrin</a></li> <li><a href="/wiki/DIMP_(antiandrogen)" title="DIMP (antiandrogen)">DIMP</a></li> <li><a href="/wiki/Endosulfan" title="Endosulfan">Endosulfan</a></li> <li><a href="/wiki/Enzalutamide" title="Enzalutamide">Enzalutamide</a></li> <li><a href="/wiki/EPI-001" title="EPI-001">EPI-001</a></li> <li><a href="/wiki/Fenarimol" title="Fenarimol">Fenarimol</a></li> <li><a href="/wiki/Flutamide" title="Flutamide">Flutamide</a></li> <li><a href="/wiki/Hydroxyflutamide" title="Hydroxyflutamide">Hydroxyflutamide</a></li> <li><a href="/wiki/Inocoterone" title="Inocoterone">Inocoterone</a></li> <li><a href="/wiki/Inocoterone_acetate" title="Inocoterone acetate">Inocoterone acetate</a></li> <li><a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a></li> <li><a href="/wiki/Ketodarolutamide" title="Ketodarolutamide">Ketodarolutamide</a></li> <li><a href="/wiki/Lavender_oil" title="Lavender oil">Lavender oil</a></li> <li><a href="/w/index.php?title=LG-105&action=edit&redlink=1" class="new" title="LG-105 (page does not exist)">LG-105</a></li> <li><a href="/wiki/LG-120907" title="LG-120907">LG-120907</a></li> <li><a href="/w/index.php?title=LGD-1331&action=edit&redlink=1" class="new" title="LGD-1331 (page does not exist)">LGD-1331</a></li> <li><a href="/wiki/Linuron" title="Linuron">Linuron</a></li> <li><a href="/wiki/Masofaniten" title="Masofaniten">Masofaniten</a></li> <li><a href="/wiki/Methiocarb" title="Methiocarb">Methiocarb</a></li> <li><a href="/w/index.php?title=N-Butylbenzenesulfonamide&action=edit&redlink=1" class="new" title="N-Butylbenzenesulfonamide (page does not exist)">N-Butylbenzenesulfonamide</a></li> <li><a href="/wiki/N-Desmethylapalutamide" title="N-Desmethylapalutamide">N-Desmethylapalutamide</a></li> <li><a href="/wiki/N-Desmethylenzalutamide" title="N-Desmethylenzalutamide">N-Desmethylenzalutamide</a></li> <li><a href="/wiki/Nilutamide" title="Nilutamide">Nilutamide</a></li> <li><a href="/w/index.php?title=ONC1-13B&action=edit&redlink=1" class="new" title="ONC1-13B (page does not exist)">ONC1-13B</a></li> <li><a href="/wiki/Pentomone" title="Pentomone">Pentomone</a></li> <li><a href="/w/index.php?title=PF-998425&action=edit&redlink=1" class="new" title="PF-998425 (page does not exist)">PF-998425</a></li> <li><a href="/wiki/Phenothrin" title="Phenothrin">Phenothrin</a></li> <li><a href="/wiki/Prochloraz" title="Prochloraz">Prochloraz</a></li> <li><a href="/wiki/Procymidone" title="Procymidone">Procymidone</a></li> <li><a href="/wiki/Proxalutamide" title="Proxalutamide">Proxalutamide</a></li> <li><a href="/wiki/Pyrilutamide" title="Pyrilutamide">Pyrilutamide</a></li> <li><a href="/wiki/Ralaniten" title="Ralaniten">Ralaniten (EPI-002)</a></li> <li><a href="/wiki/Ralaniten_acetate" title="Ralaniten acetate">Ralaniten acetate (EPI-506)</a></li> <li><a href="/wiki/RD-162" title="RD-162">RD-162</a></li> <li><a href="/wiki/Rezvilutamide" title="Rezvilutamide">Rezvilutamide</a></li> <li><a href="/w/index.php?title=Ro_2-7239&action=edit&redlink=1" class="new" title="Ro 2-7239 (page does not exist)">Ro 2-7239</a></li> <li><a href="/w/index.php?title=Ro_5-2537&action=edit&redlink=1" class="new" title="Ro 5-2537 (page does not exist)">Ro 5-2537</a></li> <li><a href="/wiki/RU-22930" title="RU-22930">RU-22930</a></li> <li><a href="/wiki/RU-56187" title="RU-56187">RU-56187</a></li> <li><a href="/wiki/RU-57073" title="RU-57073">RU-57073</a></li> <li><a href="/wiki/RU-58642" title="RU-58642">RU-58642</a></li> <li><a href="/wiki/RU-58841" title="RU-58841">RU-58841</a></li> <li><a href="/wiki/Seviteronel" title="Seviteronel">Seviteronel</a></li> <li><a href="/wiki/Thalidomide" title="Thalidomide">Thalidomide</a></li> <li><a href="/wiki/Topilutamide" title="Topilutamide">Topilutamide (fluridil)</a></li> <li><a href="/wiki/Valproic_acid" class="mw-redirect" title="Valproic acid">Valproic acid</a></li> <li><a href="/wiki/Vinclozolin" title="Vinclozolin">Vinclozolin</a></li> <li><a href="/w/index.php?title=YM-580&action=edit&redlink=1" class="new" title="YM-580 (page does not exist)">YM-580</a></li> <li><a href="/w/index.php?title=YM-92088&action=edit&redlink=1" class="new" title="YM-92088 (page does not exist)">YM-92088</a></li> <li><a href="/w/index.php?title=YM-175735&action=edit&redlink=1" class="new" title="YM-175735 (page does not exist)">YM-175735</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GPRC6A" title="GPRC6A">GPRC6A</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center;">Agonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cation" class="mw-redirect" title="Cation">Cations</a> (incl. <a href="/wiki/Aluminium" title="Aluminium">aluminium</a>, <a href="/wiki/Calcium" title="Calcium">calcium</a>, <a href="/wiki/Gadolinium" title="Gadolinium">gadolinium</a>, <a href="/wiki/Magnesium" title="Magnesium">magnesium</a>, <a href="/wiki/Strontium" title="Strontium">strontium</a>, <a href="/wiki/Zinc" title="Zinc">zinc</a>)</li> <li><a href="/wiki/Dehydroandrosterone" title="Dehydroandrosterone">Dehydroandrosterone</a></li> <li><a href="/wiki/Dihydrotestosterone" title="Dihydrotestosterone">Dihydrotestosterone</a></li> <li><a href="/wiki/Estradiol" title="Estradiol">Estradiol</a></li> <li><a href="/wiki/Amino_acid" title="Amino acid">L-α-Amino acids</a> (incl. <a href="/wiki/Arginine" title="Arginine">L-arginine</a>, <a href="/wiki/Lysine" title="Lysine">L-lysine</a>, <a href="/wiki/Ornithine" title="Ornithine">L-ornithine</a>)</li> <li><a href="/wiki/Osteocalcin" title="Osteocalcin">Osteocalcin</a></li> <li><a href="/wiki/Sex_hormone-binding_globulin" title="Sex hormone-binding globulin"><abbr title="Sex hormone-binding globulin">SHBG</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Sex hormone-binding globulin</li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></dd> <dd><a href="/wiki/Template:Androgens_and_antiandrogens" title="Template:Androgens and antiandrogens">Androgens and antiandrogens</a></dd> <dd><a href="/wiki/Template:Estrogen_receptor_modulators" title="Template:Estrogen receptor modulators">Estrogen receptor modulators</a></dd> <dd><a href="/wiki/Template:Progesterone_receptor_modulators" title="Template:Progesterone receptor modulators">Progesterone receptor modulators</a></dd> <dd><a href="/wiki/List_of_androgens_and_anabolic_steroids" title="List of androgens and anabolic steroids">List of androgens and anabolic steroids</a></dd></dl> </div></td></tr></tbody></table></div>    </div><noscript><img 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