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class="vector-toc-list"> </ul> </li> <li id="toc-Location_and_distribution" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Location_and_distribution"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Location and distribution</span> </div> </a> <ul id="toc-Location_and_distribution-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Genetics_and_regulation" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Genetics_and_regulation"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Genetics and regulation</span> </div> </a> <ul id="toc-Genetics_and_regulation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Biological_role_and_disorders" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Biological_role_and_disorders"> <div 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class="vector-toc-link" href="#Ligands_and_modulators"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Ligands and modulators</span> </div> </a> <button aria-controls="toc-Ligands_and_modulators-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Ligands and modulators subsection</span> </button> <ul id="toc-Ligands_and_modulators-sublist" class="vector-toc-list"> <li id="toc-Substrates" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Substrates"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.1</span> <span>Substrates</span> </div> </a> <ul id="toc-Substrates-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Dopamine_reuptake_inhibitors_(DRIs)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dopamine_reuptake_inhibitors_(DRIs)"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.2</span> <span>Dopamine reuptake inhibitors (DRIs)</span> </div> </a> <ul id="toc-Dopamine_reuptake_inhibitors_(DRIs)-sublist" class="vector-toc-list"> <li id="toc-Typical_or_classical_cocaine-like_blockers" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Typical_or_classical_cocaine-like_blockers"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.2.1</span> <span>Typical or classical cocaine-like blockers</span> </div> </a> <ul id="toc-Typical_or_classical_cocaine-like_blockers-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Atypical_non-psychostimulant_blockers" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Atypical_non-psychostimulant_blockers"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.2.2</span> <span>Atypical non-psychostimulant blockers</span> </div> </a> <ul id="toc-Atypical_non-psychostimulant_blockers-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Unsorted_blockers" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Unsorted_blockers"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.2.3</span> <span>Unsorted blockers</span> </div> </a> <ul id="toc-Unsorted_blockers-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Dopamine_releasing_agents_(DRAs)" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dopamine_releasing_agents_(DRAs)"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.3</span> <span>Dopamine releasing agents (DRAs)</span> </div> </a> <ul id="toc-Dopamine_releasing_agents_(DRAs)-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Allosteric_modulators" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Allosteric_modulators"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.4</span> <span>Allosteric modulators</span> </div> </a> <ul id="toc-Allosteric_modulators-sublist" class="vector-toc-list"> <li id="toc-Positive_allosteric_modulators" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Positive_allosteric_modulators"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.4.1</span> <span>Positive allosteric modulators</span> </div> </a> <ul id="toc-Positive_allosteric_modulators-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Negative_allosteric_modulators" class="vector-toc-list-item vector-toc-level-3"> <a class="vector-toc-link" href="#Negative_allosteric_modulators"> <div class="vector-toc-text"> <span class="vector-toc-numb">9.4.2</span> <span>Negative allosteric modulators</span> </div> </a> <ul id="toc-Negative_allosteric_modulators-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">12</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Dopamine transporter</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 13 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-13" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">13 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%86%D8%A7%D9%82%D9%84_%D8%A7%D9%84%D8%AF%D9%88%D8%A8%D8%A7%D9%85%D9%8A%D9%86" title="ناقل الدوبامين – Arabic" lang="ar" hreflang="ar" data-title="ناقل الدوبامين" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/SLC6A3" title="SLC6A3 – Welsh" lang="cy" hreflang="cy" data-title="SLC6A3" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Dopamintransporter" title="Dopamintransporter – German" lang="de" hreflang="de" data-title="Dopamintransporter" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-et mw-list-item"><a href="https://et.wikipedia.org/wiki/Dopamiini_transporter" title="Dopamiini transporter – Estonian" lang="et" hreflang="et" data-title="Dopamiini transporter" data-language-autonym="Eesti" data-language-local-name="Estonian" class="interlanguage-link-target"><span>Eesti</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Transportador_de_dopamina" title="Transportador de dopamina – Spanish" lang="es" hreflang="es" data-title="Transportador de dopamina" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%A0%D7%A9%D7%90_%D7%93%D7%95%D7%A4%D7%9E%D7%99%D7%9F" title="נשא דופמין – Hebrew" lang="he" hreflang="he" data-title="נשא דופמין" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Dopaminetransporter" title="Dopaminetransporter – Dutch" lang="nl" hreflang="nl" data-title="Dopaminetransporter" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Transportador_de_dopamina" title="Transportador de dopamina – Portuguese" lang="pt" hreflang="pt" data-title="Transportador de dopamina" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Dopaminski_transporter" title="Dopaminski transporter – Serbian" lang="sr" hreflang="sr" data-title="Dopaminski transporter" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-tt mw-list-item"><a href="https://tt.wikipedia.org/wiki/SLC6A3" title="SLC6A3 – Tatar" lang="tt" hreflang="tt" data-title="SLC6A3" data-language-autonym="Татарча / tatarça" data-language-local-name="Tatar" class="interlanguage-link-target"><span>Татарча / tatarça</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%82%E0%B8%94%E0%B8%9E%E0%B8%B2%E0%B8%A1%E0%B8%B5%E0%B8%99%E0%B8%97%E0%B8%A3%E0%B8%B2%E0%B8%99%E0%B8%AA%E0%B8%9B%E0%B8%AD%E0%B8%95%E0%B9%80%E0%B8%95%E0%B8%AD%E0%B8%A3%E0%B9%8C" title="โดพามีนทรานสปอตเตอร์ – Thai" lang="th" hreflang="th" data-title="โดพามีนทรานสปอตเตอร์" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A2%D1%80%D0%B0%D0%BD%D1%81%D0%BF%D0%BE%D1%80%D1%82%D0%B5%D1%80_%D0%B4%D0%BE%D1%84%D0%B0%D0%BC%D1%96%D0%BD%D1%83" title="Транспортер дофаміну – Ukrainian" lang="uk" hreflang="uk" data-title="Транспортер дофаміну" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%A4%9A%E5%B7%B4%E8%83%BA%E8%BD%89%E9%81%8B%E9%AB%94" title="多巴胺轉運體 – Chinese" lang="zh" hreflang="zh" data-title="多巴胺轉運體" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q2271947#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div 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style="text-align:center;font-size:125%;font-weight:bold">SLC6A3</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Dopamine_Transporter.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c8/Dopamine_Transporter.jpg/250px-Dopamine_Transporter.jpg" decoding="async" width="250" height="172" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c8/Dopamine_Transporter.jpg/375px-Dopamine_Transporter.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c8/Dopamine_Transporter.jpg/500px-Dopamine_Transporter.jpg 2x" data-file-width="695" data-file-height="479" /></a></span></td></tr><tr><th colspan="4" style="text-align:center;background-color:#ddd">Identifiers</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/11049">SLC6A3</a></span>, solute carrier family 6 (neurotransmitter transporter), member 3, DAT, DAT1, PKDYS, solute carrier family 6 member 3, Dopamine transporter, PKDYS1</td></tr><tr><th scope="row" style="background-color:#c3fdb8">External IDs</th><td colspan="3" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/126455">126455</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:94862">94862</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=55547">55547</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A3">SLC6A3</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000142319">SLC6A3 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_5.svg" class="mw-file-description" title="Chromosome 5 (human)"><img alt="Chromosome 5 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/300px-Ideogram_human_chromosome_5.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/450px-Ideogram_human_chromosome_5.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/61/Ideogram_human_chromosome_5.svg/600px-Ideogram_human_chromosome_5.svg.png 2x" data-file-width="500" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks"><a href="/wiki/Chromosome_5_(human)" class="mw-redirect" title="Chromosome 5 (human)">Chromosome 5 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_5_ideogram.svg" class="mw-file-description" title="Chromosome 5 (human)"><img alt="Chromosome 5 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/300px-Human_chromosome_5_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/450px-Human_chromosome_5_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a2/Human_chromosome_5_ideogram.svg/600px-Human_chromosome_5_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: -3.1007082326134px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SLC6A3"><img alt="Genomic location for SLC6A3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 2.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SLC6A3"><img alt="Genomic location for SLC6A3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">5p15.33</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">1,392,794 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">1,445,440 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_13.svg" class="mw-file-description" title="Chromosome 13 (mouse)"><img alt="Chromosome 13 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_house_mouse_chromosome_13.svg/260px-Ideogram_house_mouse_chromosome_13.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_house_mouse_chromosome_13.svg/390px-Ideogram_house_mouse_chromosome_13.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/04/Ideogram_house_mouse_chromosome_13.svg/520px-Ideogram_house_mouse_chromosome_13.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:#eee"><span class="plainlinks">Chromosome 13 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_13.svg" class="mw-file-description" title="Chromosome 13 (mouse)"><img alt="Chromosome 13 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/58/Ideogram_of_house_mouse_chromosome_13.svg/300px-Ideogram_of_house_mouse_chromosome_13.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/58/Ideogram_of_house_mouse_chromosome_13.svg/450px-Ideogram_of_house_mouse_chromosome_13.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/58/Ideogram_of_house_mouse_chromosome_13.svg/600px-Ideogram_of_house_mouse_chromosome_13.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 174.62853453403px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for SLC6A3"><img alt="Genomic location for SLC6A3" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 180.6px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for SLC6A3"><img alt="Genomic location for SLC6A3" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:#c3fdb8"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:#eee"><span class="plainlinks">13 C1|13 40.1 cM</span></td><th scope="row" style="background-color:#c3fdb8">Start</th><td style="background-color:#eee"><span class="plainlinks">73,684,866 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8">End</th><td style="background-color:#eee"><span class="plainlinks">73,726,791 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000142319">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">substantia nigra</li><br /><li style="line-height: 137%;">testicle</li><br /><li style="line-height: 137%;">gonad</li><br /><li style="line-height: 137%;">left lobe of thyroid gland</li><br /><li style="line-height: 137%;">right ovary</li><br /><li style="line-height: 137%;">canal of the cervix</li><br /><li style="line-height: 137%;">left ovary</li><br /><li style="line-height: 137%;">right lobe of thyroid gland</li><br /><li style="line-height: 137%;">body of uterus</li><br /><li style="line-height: 137%;">renal cortex</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000021609">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">substantia nigra</li><br /><li style="line-height: 137%;">ventral tegmental area</li><br /><li style="line-height: 137%;">embryo</li><br /><li style="line-height: 137%;">hypothalamus</li><br /><li style="line-height: 137%;">arcuate nucleus</li><br /><li style="line-height: 137%;">epithelium of small intestine</li><br /><li style="line-height: 137%;">epithelium of lens</li><br /><li style="line-height: 137%;">central gray substance of midbrain</li><br /><li style="line-height: 137%;">suprachiasmatic nucleus</li><br /><li style="line-height: 137%;">olfactory bulb</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000142319">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:#eee"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_SLC6A3_206836_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/PBB_GE_SLC6A3_206836_at_fs.png/250px-PBB_GE_SLC6A3_206836_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/7/78/PBB_GE_SLC6A3_206836_at_fs.png/375px-PBB_GE_SLC6A3_206836_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/7/78/PBB_GE_SLC6A3_206836_at_fs.png/500px-PBB_GE_SLC6A3_206836_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/6531/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Molecular function</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0047485">protein N-terminus binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005330">dopamine:sodium symporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005328">neurotransmitter:sodium symporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035240">dopamine binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015293">symporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008504">monoamine transmembrane transporter activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044877">protein-containing complex binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002020">protease binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005102">signaling receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051721">protein phosphatase 2A binding</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Cellular component</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009986">cell surface</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030424">axon</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016600">flotillin complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043025">soma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045121">membrane raft</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098793">presynapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043005">neuron projection</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098691">dopaminergic synapse</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099055">integral component of postsynaptic membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099056">integral component of presynaptic membrane</a></li></ul> </div></td></tr><tr><td style="background-color:#c3fdb8;font-weight:bold">Biological process</td><td style="background-color:#eee"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042220">response to cocaine</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060134">prepulse inhibition</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014070">response to organic cyclic compound</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007626">locomotory behavior</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042416">dopamine biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035094">response to nicotine</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007568">ageing</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042136">neurotransmitter biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015844">monoamine transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0021984">adenohypophysis development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042053">regulation of dopamine metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010039">response to iron ion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007608">sensory perception of smell</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051583">dopamine uptake involved in synaptic transmission</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042420">dopamine catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015872">dopamine transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0040018">positive regulation of multicellular organism growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051591">response to cAMP</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007595">lactation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045471">response to ethanol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006836">neurotransmitter transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090494">dopamine uptake</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0055085">transmembrane transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001504">neurotransmitter uptake</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:#eee;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:#ddd"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:#c3fdb8">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6531&rn=1">6531</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13162&rn=1">13162</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000142319;db=core">ENSG00000142319</a><br /><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000276996;db=core">ENSG00000276996</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000021609;db=core">ENSMUSG00000021609</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q01959">Q01959</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q61327">Q61327</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001044">NM_001044</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_010020">NM_010020</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001035">NP_001035</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_034150">NP_034150</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:#c3fdb8">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr5:1392794-1445440">Chr 5: 1.39 – 1.45 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr13:73684866-73726791">Chr 13: 73.68 – 73.73 Mb</a></span></td></tr><tr><th scope="row" style="background-color:#c3fdb8"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:#eee"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14865372" class="extiw" title="d:Q14865372">View/Edit Human</a></td><td colspan="2" style="background-color:#eee;text-align:center"><a href="https://www.wikidata.org/wiki/Q14865373" class="extiw" title="d:Q14865373">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p>The <b>dopamine transporter</b> (<b>DAT</b>, also <b>sodium-dependent dopamine transporter</b>) is a membrane-spanning protein coded for in humans by the <i>SLC6A3</i> <a href="/wiki/Gene" title="Gene">gene</a> (also known as <i>DAT1</i>), that pumps the <a href="/wiki/Neurotransmitter" title="Neurotransmitter">neurotransmitter</a> <a href="/wiki/Dopamine" title="Dopamine">dopamine</a> out of the <a href="/wiki/Synaptic_cleft" class="mw-redirect" title="Synaptic cleft">synaptic cleft</a> back into <a href="/wiki/Cytosol" title="Cytosol">cytosol</a>. In the cytosol, other transporters sequester the dopamine into <a href="/wiki/Vesicle_(biology_and_chemistry)" title="Vesicle (biology and chemistry)">vesicles</a> for storage and later release. Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from <a href="/wiki/Synapse" title="Synapse">synapses</a>, although there may be an exception in the <a href="/wiki/Prefrontal_cortex" title="Prefrontal cortex">prefrontal cortex</a>, where evidence points to a possibly larger role of the <a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">norepinephrine transporter</a>.<sup id="cite_ref-pmid2117046_5-0" class="reference"><a href="#cite_note-pmid2117046-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>DAT is implicated in a number of dopamine-related disorders, including <a href="/wiki/ADHD" class="mw-redirect" title="ADHD">attention deficit hyperactivity disorder</a>, <a href="/wiki/Bipolar_disorder" title="Bipolar disorder">bipolar disorder</a>, <a href="/wiki/Clinical_depression" class="mw-redirect" title="Clinical depression">clinical depression</a>, <a href="/wiki/Eating_disorder" title="Eating disorder">eating disorders</a>, and <a href="/wiki/Substance_use_disorder" title="Substance use disorder">substance use disorders</a>. The gene that encodes the DAT protein is located on <a href="/wiki/Chromosome_5" title="Chromosome 5">chromosome 5</a>, consists of 15 coding <a href="/wiki/Exons" class="mw-redirect" title="Exons">exons</a>, and is roughly 64 <a href="/wiki/Base_pair#Length_measurements" title="Base pair">kbp</a> long. Evidence for the associations between DAT and dopamine related disorders has come from a type of <a href="/wiki/Genetic_polymorphism" class="mw-redirect" title="Genetic polymorphism">genetic polymorphism</a>, known as a <a href="/wiki/Variable_number_tandem_repeat" title="Variable number tandem repeat">variable number tandem repeat</a>, in the <i>SLC6A3</i> gene, which influences the amount of protein expressed.<sup id="cite_ref-Vandenbergh_DJ_1992_1104–1106_6-0" class="reference"><a href="#cite_note-Vandenbergh_DJ_1992_1104–1106-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>DAT is an <a href="/wiki/Integral_membrane_protein" title="Integral membrane protein">integral membrane protein</a> that removes dopamine from the <a href="/wiki/Synaptic_cleft" class="mw-redirect" title="Synaptic cleft">synaptic cleft</a> and deposits it into surrounding cells, thus terminating the signal of the neurotransmitter. <a href="/wiki/Dopamine" title="Dopamine">Dopamine</a> underlies several aspects of cognition, including reward, and DAT facilitates regulation of that signal.<sup id="cite_ref-Schultz_7-0" class="reference"><a href="#cite_note-Schultz-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Mechanism">Mechanism</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=2" title="Edit section: Mechanism"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>DAT is a <a href="/wiki/Symporter" title="Symporter">symporter</a> that moves dopamine across the cell membrane by coupling the movement to the energetically-favorable movement of sodium ions moving from high to low concentration into the cell. DAT function requires the sequential binding and <a href="/wiki/Co-transport" class="mw-redirect" title="Co-transport">co-transport</a> of two <a href="/wiki/Na%2B" class="mw-redirect" title="Na+">Na<sup>+</sup></a> <a href="/wiki/Ion" title="Ion">ions</a> and one <a href="/wiki/Cl-" class="mw-redirect" title="Cl-">Cl<sup>−</sup></a> ion with the dopamine substrate. The driving force for DAT-mediated dopamine reuptake is the ion concentration gradient generated by the plasma membrane <a href="/wiki/Na%2B/K%2B_ATPase" class="mw-redirect" title="Na+/K+ ATPase">Na<sup>+</sup>/K<sup>+</sup> ATPase</a>.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>In the most widely accepted <a href="/wiki/Model" title="Model">model</a> for <a href="/wiki/Monoamine_transporter" title="Monoamine transporter">monoamine transporter</a> function, sodium ions must bind to the extracellular domain of the transporter before dopamine can bind. Once dopamine binds, the protein undergoes a conformational change, which allows both sodium and dopamine to unbind on the intracellular side of the membrane.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p><p>Studies using <a href="/wiki/Electrophysiology" title="Electrophysiology">electrophysiology</a> and <a href="/wiki/Radioactive_tracer" title="Radioactive tracer">radioactive-labeled</a> dopamine have confirmed that the dopamine transporter is similar to other monoamine transporters in that one molecule of neurotransmitter can be transported across the membrane with one or two sodium ions. Chloride ions are also needed to prevent a buildup of positive charge. These studies have also shown that transport rate and direction is totally dependent on the sodium gradient.<sup id="cite_ref-wheeler_10-0" class="reference"><a href="#cite_note-wheeler-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Because of the tight coupling of the <a href="/wiki/Membrane_potential" title="Membrane potential">membrane potential</a> and the sodium gradient, activity-induced changes in membrane polarity can dramatically influence transport rates. In addition, the transporter may contribute to dopamine release when the neuron depolarizes.<sup id="cite_ref-wheeler_10-1" class="reference"><a href="#cite_note-wheeler-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="DAT–Cav_coupling"><span id="DAT.E2.80.93Cav_coupling"></span>DAT–Ca<sub>v</sub> coupling <span class="anchor" id="DAT-CaV_coupling"></span></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=3" title="Edit section: DAT–Cav coupling"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Preliminary evidence suggests that the dopamine transporter couples to L-type <a href="/wiki/Voltage-gated_calcium_channels" class="mw-redirect" title="Voltage-gated calcium channels">voltage-gated calcium channels</a> (particularly <a href="/wiki/Cav1.2" title="Cav1.2">Ca<sub>v</sub>1.2</a> and <a href="/wiki/Cav1.3" title="Cav1.3">Ca<sub>v</sub>1.3</a>), which are expressed in virtually all dopamine neurons.<sup id="cite_ref-DAT-CaV_coupling_11-0" class="reference"><a href="#cite_note-DAT-CaV_coupling-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> As a result of DAT–Ca<sub>v</sub> coupling, DAT substrates that produce <a href="/wiki/Depolarization" title="Depolarization">depolarizing</a> currents through the transporter are able to open calcium channels that are coupled to the transporter, resulting in a calcium influx in dopamine neurons.<sup id="cite_ref-DAT-CaV_coupling_11-1" class="reference"><a href="#cite_note-DAT-CaV_coupling-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> This calcium influx is believed to induce <a href="/wiki/CAMKII" class="mw-redirect" title="CAMKII">CAMKII</a>-mediated <a href="/wiki/Phosphorylation" title="Phosphorylation">phosphorylation</a> of the dopamine transporter as a downstream effect;<sup id="cite_ref-DAT-CaV_coupling_11-2" class="reference"><a href="#cite_note-DAT-CaV_coupling-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> since DAT phosphorylation by CAMKII results in dopamine efflux <a href="/wiki/In_vivo" title="In vivo">in vivo</a>, activation of transporter-coupled calcium channels is a potential mechanism by which certain drugs (e.g., <a href="/wiki/Amphetamine" title="Amphetamine">amphetamine</a>) trigger neurotransmitter release.<sup id="cite_ref-DAT-CaV_coupling_11-3" class="reference"><a href="#cite_note-DAT-CaV_coupling-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Protein_structure">Protein structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=4" title="Edit section: Protein structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The initial determination of the membrane topology of DAT was based upon <a href="/wiki/Hydrophilicity_plot" title="Hydrophilicity plot">hydrophobic sequence analysis</a> and sequence similarities with the GABA transporter. These methods predicted twelve <a href="/wiki/Transmembrane_domain" title="Transmembrane domain">transmembrane domains</a> (TMD) with a large extracellular loop between the third and fourth TMDs.<sup id="cite_ref-kilty_12-0" class="reference"><a href="#cite_note-kilty-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Further characterization of this protein used <a href="/wiki/Proteases" class="mw-redirect" title="Proteases">proteases</a>, which digest proteins into smaller fragments, and <a href="/wiki/Glycosylation" title="Glycosylation">glycosylation</a>, which occurs only on extracellular loops, and largely verified the initial predictions of membrane topology.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> The exact structure of the <a href="/wiki/Drosophila_melanogaster" title="Drosophila melanogaster">Drosophila melanogaster</a> dopamine transporter (dDAT) was elucidated in 2013 by <a href="/wiki/X-ray_crystallography" title="X-ray crystallography">X-ray crystallography</a>.<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Location_and_distribution">Location and distribution</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=5" title="Edit section: Location and distribution"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="skin-invert-image"> <table role="presentation" cellpadding="0" style="border-spacing:0; clear:right; float:right;"> <tbody><tr> <td><div class="thumb tright"> <div class="thumbinner" style="width:542px;"> <div style="clear: both; font-weight: bold; font-size: 106.4%; text-align: center; background-color: #F0F8FF;margin-bottom:3px;">Pharmacodynamics of amphetamine in a dopamine neuron<br /><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · 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.navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Amphetamine_pharmacodynamics" title="Template:Amphetamine pharmacodynamics"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Amphetamine_pharmacodynamics" title="Template talk:Amphetamine pharmacodynamics"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Amphetamine_pharmacodynamics" title="Special:EditPage/Template:Amphetamine pharmacodynamics"><abbr title="Edit this template">e</abbr></a></li></ul></div></div> <div style="position:relative; width:540px; height:685px; overflow:hidden; border:solid #ccc 1px; background-color:white;"> <div style="left:0px; top:0px; width:540px; position:absolute"> <span typeof="mw:File"><a href="https://commons.wikimedia.org/wiki/File:TAAR1_Dopamine.svg" title="commons:File:TAAR1 Dopamine.svg"><img alt="A pharmacodynamic model of amphetamine and TAAR1" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/10/TAAR1_Dopamine.svg/540px-TAAR1_Dopamine.svg.png" decoding="async" width="540" height="685" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/10/TAAR1_Dopamine.svg/810px-TAAR1_Dopamine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/10/TAAR1_Dopamine.svg/1080px-TAAR1_Dopamine.svg.png 2x" data-file-width="725" data-file-height="920" /></a></span> </div> <div style="text-align:center; font-size:14px; line-height:110%"> <div style="background-color:transparent; color:black"><div id="annotation_190x45" style="position:absolute; left:190px; top:45px; line-height:110%;"><span style="background-color:transparent; color:inherit;">via <b><a href="/wiki/Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">AADC</a></b></span></div></div> </div> </div> <div class="thumbcaption" style="clear:left"><div style="float:left;margin-right:0.5em"><span typeof="mw:File"><span title="The image above contains clickable links"><img alt="The image above contains clickable links" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Interactive_icon.svg/18px-Interactive_icon.svg.png" decoding="async" width="18" height="27" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Interactive_icon.svg/27px-Interactive_icon.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e6/Interactive_icon.svg/36px-Interactive_icon.svg.png 2x" data-file-width="133" data-file-height="200" /></span></span></div>Amphetamine enters the presynaptic neuron across the neuronal membrane or through <abbr title="dopamine transporter">DAT</abbr>.<sup id="cite_ref-Miller_15-0" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Once inside, it binds to <abbr title="trace amine-associated receptor 1">TAAR1</abbr> or enters synaptic vesicles through <abbr title="vesicular monoamine transporter 2">VMAT2</abbr>.<sup id="cite_ref-Miller_15-1" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-E_Weihe_16-0" class="reference"><a href="#cite_note-E_Weihe-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> When amphetamine enters synaptic vesicles through VMAT2, it collapses the vesicular pH gradient, which in turn causes dopamine to be released into the <a href="/wiki/Cytosol" title="Cytosol">cytosol</a> (light tan-colored area) through VMAT2.<sup id="cite_ref-E_Weihe_16-1" class="reference"><a href="#cite_note-E_Weihe-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Amphetamine_VMAT2_pH_gradient_17-0" class="reference"><a href="#cite_note-Amphetamine_VMAT2_pH_gradient-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> When amphetamine binds to TAAR1, it reduces the <a href="/wiki/Firing_rate_(cells)" class="mw-redirect" title="Firing rate (cells)">firing rate</a> of the dopamine neuron via <a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel">G protein-coupled inwardly rectifying potassium channels</a> (GIRKs) and activates <a href="/wiki/Protein_kinase_A" title="Protein kinase A">protein kinase A</a> (PKA) and <a href="/wiki/Protein_kinase_C" title="Protein kinase C">protein kinase C</a> (PKC), which subsequently phosphorylate DAT.<sup id="cite_ref-Miller_15-2" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-GIRK_18-0" class="reference"><a href="#cite_note-GIRK-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Genatlas_TAAR1_19-0" class="reference"><a href="#cite_note-Genatlas_TAAR1-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> <span class="nowrap">PKA phosphorylation</span> causes DAT to withdraw into the presynaptic neuron (<a href="/wiki/Endocytosis" title="Endocytosis">internalize</a>) and cease transport.<sup id="cite_ref-Miller_15-3" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> <span class="nowrap">PKC-phosphorylated</span> DAT may either operate in reverse or, like <span class="nowrap">PKA-phosphorylated</span> DAT, internalize and cease transport.<sup id="cite_ref-Miller_15-4" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> Amphetamine is also known to increase intracellular calcium, an effect which is associated with DAT phosphorylation through a <a href="/wiki/CAMKII%CE%B1" class="mw-redirect" title="CAMKIIα">CAMKIIα</a>-dependent pathway, in turn producing dopamine efflux.<sup id="cite_ref-EAAT3_20-0" class="reference"><a href="#cite_note-EAAT3-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DAT_regulation_review_21-0" class="reference"><a href="#cite_note-DAT_regulation_review-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup></div> </div> </div> </td></tr></tbody></table> </div> <p><br /> Regional distribution of DAT has been found in areas of the brain with established dopaminergic circuitry, including the <a href="/wiki/Nigrostriatal_pathway" title="Nigrostriatal pathway">nigrostriatal</a>, <a href="/wiki/Mesolimbic_pathway" title="Mesolimbic pathway">mesolimbic</a>, and <a href="/wiki/Mesocortical_pathway" title="Mesocortical pathway">mesocortical</a> pathways.<sup id="cite_ref-pmid10363710_22-0" class="reference"><a href="#cite_note-pmid10363710-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> The <a href="/wiki/Nucleus_(neuroanatomy)" title="Nucleus (neuroanatomy)">nuclei</a> that make up these pathways have distinct patterns of expression. Gene expression patterns in the adult mouse show high expression in the <a href="/wiki/Substantia_nigra" title="Substantia nigra">substantia nigra</a> pars compacta.<sup id="cite_ref-pmid17437647_23-0" class="reference"><a href="#cite_note-pmid17437647-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p><p>DAT in the <a href="/wiki/Mesocortical_pathway" title="Mesocortical pathway">mesocortical pathway</a>, labeled with radioactive antibodies, was found to be enriched in dendrites and cell bodies of neurons in the <a href="/wiki/Substantia_nigra" title="Substantia nigra">substantia nigra</a> pars compacta and <a href="/wiki/Ventral_tegmental_area" title="Ventral tegmental area">ventral tegmental area</a>. This pattern makes sense for a protein that regulates dopamine levels in the synapse. </p><p>Staining in the <a href="/wiki/Striatum" title="Striatum">striatum</a> and <a href="/wiki/Nucleus_accumbens" title="Nucleus accumbens">nucleus accumbens</a> of the mesolimbic pathway was dense and heterogeneous. In the striatum, DAT is localized in the plasma membrane of axon terminals. Double <a href="/wiki/Immunocytochemistry" title="Immunocytochemistry">immunocytochemistry</a> demonstrated DAT colocalization with two other markers of <a href="/wiki/Nigrostriatal" class="mw-redirect" title="Nigrostriatal">nigrostriatal</a> terminals, <a href="/wiki/Tyrosine_hydroxylase" title="Tyrosine hydroxylase">tyrosine hydroxylase</a> and <a href="/wiki/Receptors,_dopamine_d2" class="mw-redirect" title="Receptors, dopamine d2">D2 dopamine receptors</a>. The latter was thus demonstrated to be an <a href="/wiki/Autoreceptor" title="Autoreceptor">autoreceptor</a> on cells that release dopamine. <a href="/wiki/TAAR1" title="TAAR1">TAAR1</a> is a presynaptic intracellular receptor that is also <a href="https://en.wiktionary.org/wiki/colocalized" class="extiw" title="wikt:colocalized">colocalized</a> with DAT and which has the opposite effect of the D2 autoreceptor when activated;<sup id="cite_ref-Miller_15-5" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TAAR1_IUPHAR_24-0" class="reference"><a href="#cite_note-TAAR1_IUPHAR-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> i.e., it internalizes dopamine transporters and induces efflux through reversed transporter function via <a href="/wiki/Protein_kinase_A" title="Protein kinase A">PKA</a> and <a href="/wiki/Protein_kinase_C" title="Protein kinase C">PKC</a> signaling. </p><p>Surprisingly, DAT was not identified within any synaptic active zones. These results suggest that striatal dopamine reuptake may occur outside of synaptic specializations once dopamine diffuses from the synaptic cleft. </p><p>In the <a href="/wiki/Substantia_nigra" title="Substantia nigra">substantia nigra</a>, DAT is localized to axonal and dendritic (i.e., pre- and post-synaptic) <a href="/wiki/Plasma_membranes" class="mw-redirect" title="Plasma membranes">plasma membranes</a>.<sup id="cite_ref-pmid8551328_25-0" class="reference"><a href="#cite_note-pmid8551328-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p><p>Within the <a href="/wiki/Perikarya" class="mw-redirect" title="Perikarya">perikarya</a> of <a href="/wiki/Pars_compacta" title="Pars compacta">pars compacta</a> neurons, DAT was localized primarily to rough and smooth endoplasmic reticulum, <a href="/wiki/Golgi_complex" class="mw-redirect" title="Golgi complex">Golgi complex</a>, and multivesicular bodies, identifying probable sites of synthesis, modification, transport, and degradation.<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Genetics_and_regulation">Genetics and regulation</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=6" title="Edit section: Genetics and regulation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/Gene" title="Gene">gene</a> for DAT, known as <a href="/wiki/DAT1" class="mw-redirect" title="DAT1">DAT1</a>, is located on chromosome 5p15.<sup id="cite_ref-Vandenbergh_DJ_1992_1104–1106_6-1" class="reference"><a href="#cite_note-Vandenbergh_DJ_1992_1104–1106-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> The protein encoding region of the gene is over 64 kb long and comprises 15 coding segments or <a href="/wiki/Exons" class="mw-redirect" title="Exons">exons</a>.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> This gene has a <a href="/wiki/Variable_number_tandem_repeat" title="Variable number tandem repeat">variable number tandem repeat</a> (VNTR) at the 3’ end (<a href="/wiki/Rs28363170" title="Rs28363170">rs28363170</a>) and another in the <a href="/wiki/Intron" title="Intron">intron</a> 8 region.<sup id="cite_ref-pmid8500798_28-0" class="reference"><a href="#cite_note-pmid8500798-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> Differences in the VNTR have been shown to affect the basal level of expression of the transporter; consequently, researchers have looked for associations with dopamine-related disorders.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p><p><a href="/wiki/Nuclear_receptor_related_1_protein" class="mw-redirect" title="Nuclear receptor related 1 protein">Nurr1</a>, a <a href="/wiki/Nuclear_receptor" title="Nuclear receptor">nuclear receptor</a> that regulates many dopamine-related genes, can bind the <a href="/wiki/Promoter_(biology)" class="mw-redirect" title="Promoter (biology)">promoter</a> region of this gene and induce expression.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> This promoter may also be the target of the <a href="/wiki/Transcription_factor" title="Transcription factor">transcription factor</a> <a href="/wiki/Sp1_transcription_factor" class="mw-redirect" title="Sp1 transcription factor">Sp-1</a>. </p><p>While transcription factors control which cells express DAT, functional regulation of this protein is largely accomplished by <a href="/wiki/Kinases" class="mw-redirect" title="Kinases">kinases</a>. <a href="/wiki/MAPK" class="mw-redirect" title="MAPK">MAPK</a>,<sup id="cite_ref-pmid13679416_31-0" class="reference"><a href="#cite_note-pmid13679416-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> <a href="/wiki/CAMKII" class="mw-redirect" title="CAMKII">CAMKII</a>,<sup id="cite_ref-EAAT3_20-1" class="reference"><a href="#cite_note-EAAT3-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DAT_regulation_review_21-1" class="reference"><a href="#cite_note-DAT_regulation_review-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Protein_kinase_A" title="Protein kinase A">PKA</a>,<sup id="cite_ref-Miller_15-6" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Protein_kinase_C" title="Protein kinase C">PKC</a><sup id="cite_ref-DAT_regulation_review_21-2" class="reference"><a href="#cite_note-DAT_regulation_review-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9704884_32-0" class="reference"><a href="#cite_note-pmid9704884-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> can modulate the rate at which the transporter moves dopamine or cause the internalization of DAT. Co-localized <a href="/wiki/TAAR1" title="TAAR1">TAAR1</a> is an important regulator of the dopamine transporter that, when activated, phosphorylates DAT through <a href="/wiki/Protein_kinase_A" title="Protein kinase A">protein kinase A</a> (PKA) and <a href="/wiki/Protein_kinase_C" title="Protein kinase C">protein kinase C</a> (PKC) signaling.<sup id="cite_ref-Miller_15-7" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Lindemann_2005_33-0" class="reference"><a href="#cite_note-Lindemann_2005-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Phosphorylation" title="Phosphorylation">Phosphorylation</a> by either protein kinase can result in DAT <a href="/wiki/Endocytosis" title="Endocytosis">internalization</a> (<span class="nowrap">non-competitive</span> reuptake inhibition), but <span class="nowrap">PKC-mediated</span> phosphorylation alone induces reverse transporter function (dopamine <a href="https://en.wiktionary.org/wiki/efflux" class="extiw" title="wikt:efflux">efflux</a>).<sup id="cite_ref-Miller_15-8" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TAAR1_Review_34-0" class="reference"><a href="#cite_note-TAAR1_Review-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> <a href="/wiki/D2sh" class="mw-redirect" title="D2sh">Dopamine autoreceptors</a> also regulate DAT by directly opposing the effect of TAAR1 activation.<sup id="cite_ref-Miller_15-9" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>The human dopamine transporter (hDAT) contains a <a href="/wiki/Affinity_(pharmacology)" class="mw-redirect" title="Affinity (pharmacology)">high affinity</a> extracellular <a href="/wiki/Zinc" title="Zinc">zinc</a> <a href="/wiki/Binding_site" title="Binding site">binding site</a> which, upon zinc binding, inhibits dopamine <a href="/wiki/Reuptake" title="Reuptake">reuptake</a> and amplifies <a href="/wiki/Amphetamine" title="Amphetamine">amphetamine</a>-induced <a href="/wiki/Neurotransmitter_efflux" class="mw-redirect" title="Neurotransmitter efflux">dopamine efflux</a> <i><a href="/wiki/In_vitro" title="In vitro">in vitro</a></i>.<sup id="cite_ref-Zinc_binding_sites_+_ADHD_review_35-0" class="reference"><a href="#cite_note-Zinc_binding_sites_+_ADHD_review-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Review_-_cites_2002_amph-zinc_primary_study_36-0" class="reference"><a href="#cite_note-Review_-_cites_2002_amph-zinc_primary_study-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Primary_2002_amph-zinc_study_37-0" class="reference"><a href="#cite_note-Primary_2002_amph-zinc_study-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> In contrast, the human <a href="/wiki/Serotonin_transporter" title="Serotonin transporter">serotonin transporter</a> (hSERT) and human <a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">norepinephrine transporter</a> (hNET) do not contain zinc binding sites.<sup id="cite_ref-Primary_2002_amph-zinc_study_37-1" class="reference"><a href="#cite_note-Primary_2002_amph-zinc_study-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Zinc_supplementation" class="mw-redirect" title="Zinc supplementation">Zinc supplementation</a> may reduce the minimum <a href="/wiki/Effective_dose_(pharmacology)" title="Effective dose (pharmacology)">effective dose</a> of amphetamine when it is used for the treatment of <a href="/wiki/Attention_deficit_hyperactivity_disorder" title="Attention deficit hyperactivity disorder">attention deficit hyperactivity disorder</a>.<sup id="cite_ref-Zinc_and_PEA_38-0" class="reference"><a href="#cite_note-Zinc_and_PEA-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Biological_role_and_disorders">Biological role and disorders</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=7" title="Edit section: Biological role and disorders"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The rate at which DAT removes dopamine from the synapse can have a profound effect on the amount of dopamine in the cell. This is best evidenced by the severe cognitive deficits, motor abnormalities, and hyperactivity of mice with no dopamine transporters.<sup id="cite_ref-39" class="reference"><a href="#cite_note-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> These characteristics have striking similarities to the symptoms of <a href="/wiki/ADHD" class="mw-redirect" title="ADHD">ADHD</a>. </p><p>Differences in the functional <a href="/wiki/VNTR" class="mw-redirect" title="VNTR">VNTR</a> have been identified as risk factors for bipolar disorder<sup id="cite_ref-pmid11304827_40-0" class="reference"><a href="#cite_note-pmid11304827-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> and ADHD.<sup id="cite_ref-41" class="reference"><a href="#cite_note-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> Data has emerged that suggests there is also an association with stronger <a href="/wiki/Alcohol_withdrawal" class="mw-redirect" title="Alcohol withdrawal">withdrawal</a> symptoms from <a href="/wiki/Alcoholism" title="Alcoholism">alcoholism</a>, although this is a point of controversy.<sup id="cite_ref-pmid9024952_43-0" class="reference"><a href="#cite_note-pmid9024952-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10578237_44-0" class="reference"><a href="#cite_note-pmid10578237-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> An <a href="/wiki/Allele" title="Allele">allele</a> of the DAT gene with normal protein levels is associated with non-smoking behavior and ease of quitting.<sup id="cite_ref-pmid12630565_45-0" class="reference"><a href="#cite_note-pmid12630565-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> Additionally, male adolescents particularly those in high-risk families (ones marked by a disengaged mother and absence of maternal affection) who carry the 10-allele VNTR repeat show a statistically significant affinity for antisocial peers.<sup id="cite_ref-pmid18788325_46-0" class="reference"><a href="#cite_note-pmid18788325-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> </p><p>Increased activity of DAT is associated with several different disorders, including <a href="/wiki/Clinical_depression" class="mw-redirect" title="Clinical depression">clinical depression</a>.<sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </p><p>Mutations in DAT have been shown to cause <a href="/wiki/Dopamine_transporter_deficiency_syndrome" title="Dopamine transporter deficiency syndrome">dopamine transporter deficiency syndrome</a>, an <a href="/wiki/Autosomal_Recessive" class="mw-redirect" title="Autosomal Recessive">autosomal recessive</a> <a href="/wiki/Movement_disorders" class="mw-redirect" title="Movement disorders">movement disorder</a> characterized by progressively worsening <a href="/wiki/Dystonia" title="Dystonia">dystonia</a> and <a href="/wiki/Parkinsonism" title="Parkinsonism">parkinsonism</a>.<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=8" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The dopamine transporter is the target of <a href="/wiki/Substrate_(chemistry)" title="Substrate (chemistry)">substrates</a>, <a href="/wiki/Monoamine_releasing_agent" title="Monoamine releasing agent">dopamine releasers</a>, <a href="/wiki/Dopamine_reuptake_inhibitor" title="Dopamine reuptake inhibitor">transport inhibitors</a> and <a href="/wiki/Allosteric_modulator" title="Allosteric modulator">allosteric modulators</a>.<sup id="cite_ref-pmid25788711_50-0" class="reference"><a href="#cite_note-pmid25788711-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid31184115_51-0" class="reference"><a href="#cite_note-pmid31184115-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> </p><p>Cocaine blocks DAT by binding directly to the transporter and reducing the rate of transport.<sup id="cite_ref-kilty_12-1" class="reference"><a href="#cite_note-kilty-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> In contrast, amphetamine enters the presynaptic neuron directly through the neuronal membrane or through DAT, competing for reuptake with dopamine. Once inside, it binds to <abbr title="trace amine-associated receptor 1">TAAR1</abbr> or enters synaptic vesicles through <abbr title="vesicular monoamine transporter 2">VMAT2</abbr>. When amphetamine binds to TAAR1, it reduces the firing rate of the postsynaptic neuron and triggers <a href="/wiki/Protein_kinase_A" title="Protein kinase A">protein kinase A</a> and <a href="/wiki/Protein_kinase_C" title="Protein kinase C">protein kinase C</a> signaling, resulting in DAT phosphorylation. Phosphorylated DAT then either operates in reverse or withdraws into the presynaptic neuron and ceases transport. When amphetamine enters the synaptic vesicles through VMAT2, dopamine is released into the cytosol.<sup id="cite_ref-Miller_15-10" class="reference"><a href="#cite_note-Miller-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-E_Weihe_16-2" class="reference"><a href="#cite_note-E_Weihe-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> Amphetamine also produces dopamine efflux through a second TAAR1-independent mechanism involving <a href="/wiki/CAMKII%CE%B1" class="mw-redirect" title="CAMKIIα">CAMKIIα</a>-mediated phosphorylation of the transporter, which putatively arises from the activation of <a href="#DAT-CaV_coupling">DAT-coupled L-type calcium channels</a> by amphetamine.<sup id="cite_ref-DAT-CaV_coupling_11-4" class="reference"><a href="#cite_note-DAT-CaV_coupling-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> </p><p>The dopaminergic mechanisms of each drug are believed to underlie the pleasurable feelings elicited by these substances.<sup id="cite_ref-Schultz_7-1" class="reference"><a href="#cite_note-Schultz-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=9" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Dopamine transporter has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Alpha-synuclein" title="Alpha-synuclein">Alpha-synuclein</a>,<sup id="cite_ref-pmid12672538_52-0" class="reference"><a href="#cite_note-pmid12672538-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11292651_53-0" class="reference"><a href="#cite_note-pmid11292651-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PICK1" title="PICK1">PICK1</a>,<sup id="cite_ref-pmid11343649_54-0" class="reference"><a href="#cite_note-pmid11343649-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup></li> <li>Synaptogyrin-3,<sup id="cite_ref-55" class="reference"><a href="#cite_note-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/TGFB1I1" title="TGFB1I1">TGFB1I1</a>,<sup id="cite_ref-pmid12177201_56-0" class="reference"><a href="#cite_note-pmid12177201-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup></li></ul> </div> <p>Apart from these innate protein-protein interactions, recent studies demonstrated that viral proteins such as <a href="/wiki/HIV" title="HIV">HIV-1</a> <a href="/wiki/Tat_(HIV)" title="Tat (HIV)">Tat</a> protein interacts with the DAT<sup id="cite_ref-57" class="reference"><a href="#cite_note-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-58" class="reference"><a href="#cite_note-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup> and this binding may alter the dopamine homeostasis in HIV positive individuals which is a contributing factor for the <a href="/wiki/HIV-associated_neurocognitive_disorder" title="HIV-associated neurocognitive disorder">HIV-associated neurocognitive disorders</a>.<sup id="cite_ref-59" class="reference"><a href="#cite_note-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Ligands_and_modulators">Ligands and modulators</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=10" title="Edit section: Ligands and modulators"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Substrates">Substrates</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=11" title="Edit section: Substrates"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a><sup id="cite_ref-HitriHurdWyatt1994_60-0" class="reference"><a href="#cite_note-HitriHurdWyatt1994-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SchmittRothmanReith2013_61-0" class="reference"><a href="#cite_note-SchmittRothmanReith2013-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Norepinephrine" title="Norepinephrine">Norepinephrine</a><sup id="cite_ref-HitriHurdWyatt1994_60-1" class="reference"><a href="#cite_note-HitriHurdWyatt1994-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup></li> <li>Substrate-type <a href="/wiki/Dopamine_releasing_agent" title="Dopamine releasing agent">dopamine releasing agents</a> (e.g., <a href="/wiki/Amphetamine" title="Amphetamine">amphetamine</a>)<sup id="cite_ref-ReithBloughHong2015_62-0" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SchmittRothmanReith2013_61-1" class="reference"><a href="#cite_note-SchmittRothmanReith2013-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Monoaminergic_activity_enhancer" title="Monoaminergic activity enhancer">Catecholaminergic activity enhancers</a> (e.g., <a href="/wiki/Selegiline" title="Selegiline">selegiline</a>, <a href="/wiki/Phenylpropylaminopentane" title="Phenylpropylaminopentane">PPAP</a>, <a href="/wiki/Benzofuranylpropylaminopentane" title="Benzofuranylpropylaminopentane">BPAP</a>)<sup id="cite_ref-HarsingKnollMiklya2022_63-0" class="reference"><a href="#cite_note-HarsingKnollMiklya2022-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup></li> <li>Certain <a href="/wiki/Dopaminergic_neurotoxin" class="mw-redirect" title="Dopaminergic neurotoxin">dopaminergic neurotoxins</a> (e.g., <a href="/wiki/MPTP" title="MPTP">MPTP</a>, <a href="/wiki/6-hydroxydopamine" class="mw-redirect" title="6-hydroxydopamine">6-OHDA</a>)<sup id="cite_ref-Kostrzewa2022_64-0" class="reference"><a href="#cite_note-Kostrzewa2022-64"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-StorchLudolphSchwarz2004_65-0" class="reference"><a href="#cite_note-StorchLudolphSchwarz2004-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SotnikovaBeaulieuGainetdinov2006_66-0" class="reference"><a href="#cite_note-SotnikovaBeaulieuGainetdinov2006-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading3"><h3 id="Dopamine_reuptake_inhibitors_(DRIs)"><span id="Dopamine_reuptake_inhibitors_.28DRIs.29"></span>Dopamine reuptake inhibitors (DRIs)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=12" title="Edit section: Dopamine reuptake inhibitors (DRIs)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Dopamine_reuptake_inhibitor" title="Dopamine reuptake inhibitor">Dopamine reuptake inhibitor</a></div> <div class="mw-heading mw-heading4"><h4 id="Typical_or_classical_cocaine-like_blockers">Typical or classical cocaine-like blockers</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=13" title="Edit section: Typical or classical cocaine-like blockers"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Amfonelic_acid" title="Amfonelic acid">Amfonelic acid</a><sup id="cite_ref-HitriHurdWyatt1994_60-2" class="reference"><a href="#cite_note-HitriHurdWyatt1994-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AcetoBottonMartin1970_67-0" class="reference"><a href="#cite_note-AcetoBottonMartin1970-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PorrinoGoodmanSharpe1988_68-0" class="reference"><a href="#cite_note-PorrinoGoodmanSharpe1988-68"><span class="cite-bracket">[</span>68<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Amineptine" title="Amineptine">Amineptine</a><sup id="cite_ref-Garattini1997_69-0" class="reference"><a href="#cite_note-Garattini1997-69"><span class="cite-bracket">[</span>69<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BonnettChagraouiProtais1987_70-0" class="reference"><a href="#cite_note-BonnettChagraouiProtais1987-70"><span class="cite-bracket">[</span>70<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-EvansSullivan2014_71-0" class="reference"><a href="#cite_note-EvansSullivan2014-71"><span class="cite-bracket">[</span>71<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Haddad1999_72-0" class="reference"><a href="#cite_note-Haddad1999-72"><span class="cite-bracket">[</span>72<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Benzothiophenylcyclohexylpiperidine" class="mw-redirect" title="Benzothiophenylcyclohexylpiperidine">BTCP</a><sup id="cite_ref-DuttaZhangKolhatkar2003_73-0" class="reference"><a href="#cite_note-DuttaZhangKolhatkar2003-73"><span class="cite-bracket">[</span>73<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Cocaethylene" title="Cocaethylene">Cocaethylene</a><sup id="cite_ref-PergolizziBreveMagnusson2022_74-0" class="reference"><a href="#cite_note-PergolizziBreveMagnusson2022-74"><span class="cite-bracket">[</span>74<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Landry1992_75-0" class="reference"><a href="#cite_note-Landry1992-75"><span class="cite-bracket">[</span>75<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a><sup id="cite_ref-HealGosdenSmith2014_76-0" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AggarwalMortensen2023_77-0" class="reference"><a href="#cite_note-AggarwalMortensen2023-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/JJC8-088" title="JJC8-088">JJC8-088</a><sup id="cite_ref-TandaHerseyHempel2021_78-0" class="reference"><a href="#cite_note-TandaHerseyHempel2021-78"><span class="cite-bracket">[</span>78<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NewmanKuJordan2021_79-0" class="reference"><a href="#cite_note-NewmanKuJordan2021-79"><span class="cite-bracket">[</span>79<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Methylenedioxypyrovalerone" title="Methylenedioxypyrovalerone">Methylenedioxypyrovalerone</a> (MDPV)<sup id="cite_ref-GlennonYoung2016_80-0" class="reference"><a href="#cite_note-GlennonYoung2016-80"><span class="cite-bracket">[</span>80<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BaumannPartillaLehner2013_81-0" class="reference"><a href="#cite_note-BaumannPartillaLehner2013-81"><span class="cite-bracket">[</span>81<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Methylphenidate" title="Methylphenidate">Methylphenidate</a><sup id="cite_ref-HealGosdenSmith2014_76-1" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Orphenadrine" title="Orphenadrine">Orphenadrine</a><sup id="cite_ref-NepalDasReith2023_82-0" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ChengBlockHu2015_83-0" class="reference"><a href="#cite_note-ChengBlockHu2015-83"><span class="cite-bracket">[</span>83<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine</a> (meperidine)<sup id="cite_ref-KatzNewmanIzenwasser1997_84-0" class="reference"><a href="#cite_note-KatzNewmanIzenwasser1997-84"><span class="cite-bracket">[</span>84<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BergmanFranceHoltzman2000_85-0" class="reference"><a href="#cite_note-BergmanFranceHoltzman2000-85"><span class="cite-bracket">[</span>85<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-IzenwasserNewmanCox1996_86-0" class="reference"><a href="#cite_note-IzenwasserNewmanCox1996-86"><span class="cite-bracket">[</span>86<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Pipradrol" title="Pipradrol">Pipradrol</a><sup id="cite_ref-WhiteArcher2013_87-0" class="reference"><a href="#cite_note-WhiteArcher2013-87"><span class="cite-bracket">[</span>87<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RTI-55" title="RTI-55">RTI-55</a><sup id="cite_ref-GolovkoBonitenkoIvanov2016_88-0" class="reference"><a href="#cite_note-GolovkoBonitenkoIvanov2016-88"><span class="cite-bracket">[</span>88<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Troparil" title="Troparil">Troparil</a> (WIN-35065)<sup id="cite_ref-HealGosdenSmith2014_76-2" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/WIN-35428" title="WIN-35428">WIN-35428</a> (β-CFT)<sup id="cite_ref-HealGosdenSmith2014_76-3" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-GolovkoBonitenkoIvanov2016_88-1" class="reference"><a href="#cite_note-GolovkoBonitenkoIvanov2016-88"><span class="cite-bracket">[</span>88<span class="cite-bracket">]</span></a></sup></li></ul> </div> <p>These agents may actually act as <a href="/wiki/Dopamine_releasing_agent" title="Dopamine releasing agent">dopamine releasing agent</a>-esque DAT <a href="/wiki/Negative_allosteric_modulator" class="mw-redirect" title="Negative allosteric modulator">negative allosteric modulators</a> or "<a href="/wiki/Inverse_agonist" title="Inverse agonist">inverse agonists</a>".<sup id="cite_ref-HealGosdenSmith2014_76-4" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Atypical_non-psychostimulant_blockers">Atypical non-psychostimulant blockers</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=14" title="Edit section: Atypical non-psychostimulant blockers"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Armodafinil" title="Armodafinil">Armodafinil</a><sup id="cite_ref-HerseyBaconBailey2021_89-0" class="reference"><a href="#cite_note-HerseyBaconBailey2021-89"><span class="cite-bracket">[</span>89<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Benztropine" class="mw-redirect" title="Benztropine">Benztropine</a><sup id="cite_ref-ReithBloughHong2015_62-1" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HauckNewmanKatz2008_90-0" class="reference"><a href="#cite_note-HauckNewmanKatz2008-90"><span class="cite-bracket">[</span>90<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Rothman1994_91-0" class="reference"><a href="#cite_note-Rothman1994-91"><span class="cite-bracket">[</span>91<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Bupropion" title="Bupropion">Bupropion</a><sup id="cite_ref-HealGosdenSmith2014_76-5" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup> (but some potential for cocaine-like actions)<sup id="cite_ref-NaglichBrownAdinoff2019_92-0" class="reference"><a href="#cite_note-NaglichBrownAdinoff2019-92"><span class="cite-bracket">[</span>92<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NoeShahOngchuan2024_93-0" class="reference"><a href="#cite_note-NoeShahOngchuan2024-93"><span class="cite-bracket">[</span>93<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AikoyeBasiruNwoye2023_94-0" class="reference"><a href="#cite_note-AikoyeBasiruNwoye2023-94"><span class="cite-bracket">[</span>94<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-CostaOliveiraDinis-Oliveira2019_95-0" class="reference"><a href="#cite_note-CostaOliveiraDinis-Oliveira2019-95"><span class="cite-bracket">[</span>95<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GBR-12935" title="GBR-12935">GBR-12935</a><sup id="cite_ref-HealGosdenSmith2014_76-6" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/JHW-007" title="JHW-007">JHW-007</a><sup id="cite_ref-ReithBloughHong2015_62-2" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-GolovkoBonitenkoIvanov2016_88-2" class="reference"><a href="#cite_note-GolovkoBonitenkoIvanov2016-88"><span class="cite-bracket">[</span>88<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/JJC8-091" title="JJC8-091">JJC8-091</a><sup id="cite_ref-JordanCaoNewman2019_96-0" class="reference"><a href="#cite_note-JordanCaoNewman2019-96"><span class="cite-bracket">[</span>96<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AggarwalMortensen2023_77-1" class="reference"><a href="#cite_note-AggarwalMortensen2023-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HerseyBartoleJones2023_97-0" class="reference"><a href="#cite_note-HerseyBartoleJones2023-97"><span class="cite-bracket">[</span>97<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-TandaHerseyHempel2021_78-1" class="reference"><a href="#cite_note-TandaHerseyHempel2021-78"><span class="cite-bracket">[</span>78<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Mazindol" title="Mazindol">Mazindol</a><sup id="cite_ref-HealGosdenSmith2014_76-7" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Rothman1994_91-1" class="reference"><a href="#cite_note-Rothman1994-91"><span class="cite-bracket">[</span>91<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanGlowa1995_98-0" class="reference"><a href="#cite_note-RothmanGlowa1995-98"><span class="cite-bracket">[</span>98<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/(S)-MK-26" title="(S)-MK-26">(<i>S</i>)-MK-26</a><sup id="cite_ref-SalamoneCorrea2024_99-0" class="reference"><a href="#cite_note-SalamoneCorrea2024-99"><span class="cite-bracket">[</span>99<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HerseyBartoleJones2023_97-1" class="reference"><a href="#cite_note-HerseyBartoleJones2023-97"><span class="cite-bracket">[</span>97<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-KouhnavardiEcevitogluDragačević2022_100-0" class="reference"><a href="#cite_note-KouhnavardiEcevitogluDragačević2022-100"><span class="cite-bracket">[</span>100<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Modafinil" title="Modafinil">Modafinil</a><sup id="cite_ref-ReithBloughHong2015_62-3" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HerseyBaconBailey2021_89-1" class="reference"><a href="#cite_note-HerseyBaconBailey2021-89"><span class="cite-bracket">[</span>89<span class="cite-bracket">]</span></a></sup> (but a few cases of misuse)<sup id="cite_ref-HerseyTanda2024_101-0" class="reference"><a href="#cite_note-HerseyTanda2024-101"><span class="cite-bracket">[</span>101<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Nomifensine" title="Nomifensine">Nomifensine</a><sup id="cite_ref-HealGosdenSmith2014_76-8" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Rothman1994_91-2" class="reference"><a href="#cite_note-Rothman1994-91"><span class="cite-bracket">[</span>91<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanGlowa1995_98-1" class="reference"><a href="#cite_note-RothmanGlowa1995-98"><span class="cite-bracket">[</span>98<span class="cite-bracket">]</span></a></sup> (but some cases of misuse)<sup id="cite_ref-BöningFuchs1986_102-0" class="reference"><a href="#cite_note-BöningFuchs1986-102"><span class="cite-bracket">[</span>102<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Phenylpiracetam" title="Phenylpiracetam">Phenylpiracetam</a><sup id="cite_ref-VeinbergVaversOrlova2015_103-0" class="reference"><a href="#cite_note-VeinbergVaversOrlova2015-103"><span class="cite-bracket">[</span>103<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SommerDanyszRuss2014_104-0" class="reference"><a href="#cite_note-SommerDanyszRuss2014-104"><span class="cite-bracket">[</span>104<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ZvejnieceSvalbeVavers2017_105-0" class="reference"><a href="#cite_note-ZvejnieceSvalbeVavers2017-105"><span class="cite-bracket">[</span>105<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MRZ-9547" title="MRZ-9547">(<i>R</i>)-Phenylpiracetam</a> (MRZ-9547)<sup id="cite_ref-SalamoneCorrea2024_99-1" class="reference"><a href="#cite_note-SalamoneCorrea2024-99"><span class="cite-bracket">[</span>99<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-StutzGolaniWitkin2019_106-0" class="reference"><a href="#cite_note-StutzGolaniWitkin2019-106"><span class="cite-bracket">[</span>106<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SommerDanyszRuss2014_104-1" class="reference"><a href="#cite_note-SommerDanyszRuss2014-104"><span class="cite-bracket">[</span>104<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-DekundyMelaHofmann2015_107-0" class="reference"><a href="#cite_note-DekundyMelaHofmann2015-107"><span class="cite-bracket">[</span>107<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/RDS03-94" title="RDS03-94">RDS03-94</a><sup id="cite_ref-TandaHerseyHempel2021_78-2" class="reference"><a href="#cite_note-TandaHerseyHempel2021-78"><span class="cite-bracket">[</span>78<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Rimcazole" title="Rimcazole">Rimcazole</a><sup id="cite_ref-ReithBloughHong2015_62-4" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Sibutramine" title="Sibutramine">Sibutramine</a><sup id="cite_ref-HealGosdenSmith2014_76-9" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Solriamfetol" title="Solriamfetol">Solriamfetol</a><sup id="cite_ref-NgoPlante2022_108-0" class="reference"><a href="#cite_note-NgoPlante2022-108"><span class="cite-bracket">[</span>108<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-YangGao2019_109-0" class="reference"><a href="#cite_note-YangGao2019-109"><span class="cite-bracket">[</span>109<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Tamoxifen" title="Tamoxifen">Tamoxifen</a><sup id="cite_ref-NepalDasReith2023_82-1" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MikelmanGuptaroySchmitt2018_110-0" class="reference"><a href="#cite_note-MikelmanGuptaroySchmitt2018-110"><span class="cite-bracket">[</span>110<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Tesofensine" title="Tesofensine">Tesofensine</a><sup id="cite_ref-HealGosdenSmith2014_76-10" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Vanoxerine" title="Vanoxerine">Vanoxerine</a> (GBR-12909)<sup id="cite_ref-HealGosdenSmith2014_76-11" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ReithBloughHong2015_62-5" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanGlowa1995_98-2" class="reference"><a href="#cite_note-RothmanGlowa1995-98"><span class="cite-bracket">[</span>98<span class="cite-bracket">]</span></a></sup></li></ul> </div> <p>These agents may actually act as simple competitive DAT blockers without releaser-like "inverse agonist" activity.<sup id="cite_ref-HealGosdenSmith2014_76-12" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading4"><h4 id="Unsorted_blockers">Unsorted blockers</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=15" title="Edit section: Unsorted blockers"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Indatraline" title="Indatraline">Indatraline</a><sup id="cite_ref-RothmanBaumann2003_111-0" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2006_112-0" class="reference"><a href="#cite_note-RothmanBaumann2006-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PRX-14040" title="PRX-14040">PRX-14040</a><sup id="cite_ref-SalamoneCorrea2024_99-2" class="reference"><a href="#cite_note-SalamoneCorrea2024-99"><span class="cite-bracket">[</span>99<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SalamoneCorreaFerrigno2018_113-0" class="reference"><a href="#cite_note-SalamoneCorreaFerrigno2018-113"><span class="cite-bracket">[</span>113<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Desibhatla2021_114-0" class="reference"><a href="#cite_note-Desibhatla2021-114"><span class="cite-bracket">[</span>114<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-YohnGogojHaque2016_115-0" class="reference"><a href="#cite_note-YohnGogojHaque2016-115"><span class="cite-bracket">[</span>115<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading3"><h3 id="Dopamine_releasing_agents_(DRAs)"><span id="Dopamine_releasing_agents_.28DRAs.29"></span>Dopamine releasing agents (DRAs)</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=16" title="Edit section: Dopamine releasing agents (DRAs)"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236090951"><div role="note" class="hatnote navigation-not-searchable">Main article: <a href="/wiki/Dopamine_releasing_agent" title="Dopamine releasing agent">Dopamine releasing agent</a></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/2-Aminoindane" title="2-Aminoindane">2-Aminoindane</a> (2-AI)<sup id="cite_ref-PinterovaHorsleyPalenicek2017_116-0" class="reference"><a href="#cite_note-PinterovaHorsleyPalenicek2017-116"><span class="cite-bracket">[</span>116<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SimmlerRickliSchramm2014_117-0" class="reference"><a href="#cite_note-SimmlerRickliSchramm2014-117"><span class="cite-bracket">[</span>117<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/5-Chloro-%CE%B1MT" title="5-Chloro-αMT">5-Chloro-αMT</a><sup id="cite_ref-BloughLandavazoPartilla2014_118-0" class="reference"><a href="#cite_note-BloughLandavazoPartilla2014-118"><span class="cite-bracket">[</span>118<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BanksBauerBlough2014_119-0" class="reference"><a href="#cite_note-BanksBauerBlough2014-119"><span class="cite-bracket">[</span>119<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/%CE%91-Ethyltryptamine" title="Α-Ethyltryptamine">α-Ethyltryptamine</a> (αET)<sup id="cite_ref-GlennonDukat2023_120-0" class="reference"><a href="#cite_note-GlennonDukat2023-120"><span class="cite-bracket">[</span>120<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Oeri2021_121-0" class="reference"><a href="#cite_note-Oeri2021-121"><span class="cite-bracket">[</span>121<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BloughLandavazo2014_122-0" class="reference"><a href="#cite_note-BloughLandavazo2014-122"><span class="cite-bracket">[</span>122<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/%CE%91-Methyltryptamine" title="Α-Methyltryptamine">α-Methyltryptamine</a> (αMT)<sup id="cite_ref-BloughLandavazo2014_122-1" class="reference"><a href="#cite_note-BloughLandavazo2014-122"><span class="cite-bracket">[</span>122<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Aminorex" title="Aminorex">Aminorex</a><sup id="cite_ref-RothmanBaumann2003_111-1" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2006_112-1" class="reference"><a href="#cite_note-RothmanBaumann2006-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Amphetamine" title="Amphetamine">Amphetamine</a> (both <a href="/wiki/Dextroamphetamine" title="Dextroamphetamine">dextro-</a> and <a href="/wiki/Levoamphetamine" title="Levoamphetamine">levoamphetamine</a>)<sup id="cite_ref-HealGosdenSmith2014_76-13" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2003_111-2" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Benzylpiperazine" title="Benzylpiperazine">Benzylpiperazine</a> (BZP)<sup id="cite_ref-RothmanBaumann2006_112-2" class="reference"><a href="#cite_note-RothmanBaumann2006-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Cathine" title="Cathine">Cathine</a><sup id="cite_ref-RothmanBaumann2005_123-0" class="reference"><a href="#cite_note-RothmanBaumann2005-123"><span class="cite-bracket">[</span>123<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanVuPartilla2003_124-0" class="reference"><a href="#cite_note-RothmanVuPartilla2003-124"><span class="cite-bracket">[</span>124<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Cathinone" title="Cathinone">Cathinone</a><sup id="cite_ref-ReithBloughHong2015_62-6" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2006_112-3" class="reference"><a href="#cite_note-RothmanBaumann2006-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Ephedrine" title="Ephedrine">Ephedrine</a><sup id="cite_ref-RothmanBaumann2006_112-4" class="reference"><a href="#cite_note-RothmanBaumann2006-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Lisdexamfetamine" title="Lisdexamfetamine">Lisdexamfetamine</a> (LDX)<sup id="cite_ref-HutsonPennickSecker2014_125-0" class="reference"><a href="#cite_note-HutsonPennickSecker2014-125"><span class="cite-bracket">[</span>125<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HealCheethamSmith2009_126-0" class="reference"><a href="#cite_note-HealCheethamSmith2009-126"><span class="cite-bracket">[</span>126<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">Methylenedioxyamphetamine</a> (MDA)<sup id="cite_ref-SchmittRothmanReith2013_61-2" class="reference"><a href="#cite_note-SchmittRothmanReith2013-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2006_112-5" class="reference"><a href="#cite_note-RothmanBaumann2006-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/3,4-Methylenedioxy-N-ethylamphetamine" title="3,4-Methylenedioxy-N-ethylamphetamine">Methylenedioxyethylamphetamine</a> (MDEA)<sup id="cite_ref-ReithBloughHong2015_62-7" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/3,4-Methylenedioxy-N-methylamphetamine" class="mw-redirect" title="3,4-Methylenedioxy-N-methylamphetamine">Methylenedioxymethamphetamine</a> (MDMA)<sup id="cite_ref-RothmanBaumann2003_111-3" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SchmittRothmanReith2013_61-3" class="reference"><a href="#cite_note-SchmittRothmanReith2013-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Mephedrone" title="Mephedrone">Mephedrone</a><sup id="cite_ref-GreenKingShortall2014_127-0" class="reference"><a href="#cite_note-GreenKingShortall2014-127"><span class="cite-bracket">[</span>127<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SimmonsLeyrer-JacksonOliver2018_128-0" class="reference"><a href="#cite_note-SimmonsLeyrer-JacksonOliver2018-128"><span class="cite-bracket">[</span>128<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BaumannAyestasPartilla2012_129-0" class="reference"><a href="#cite_note-BaumannAyestasPartilla2012-129"><span class="cite-bracket">[</span>129<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Methamphetamine" title="Methamphetamine">Methamphetamine</a><sup id="cite_ref-HealGosdenSmith2014_76-14" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2003_111-4" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Methylone" title="Methylone">Methylone</a><sup id="cite_ref-ReithBloughHong2015_62-8" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BaumannAyestasPartilla2012_129-1" class="reference"><a href="#cite_note-BaumannAyestasPartilla2012-129"><span class="cite-bracket">[</span>129<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Naphthylisopropylamine" class="mw-redirect" title="Naphthylisopropylamine">Naphthylisopropylamine</a> (PAL-287)<sup id="cite_ref-RothmanBloughBaumann2007_130-0" class="reference"><a href="#cite_note-RothmanBloughBaumann2007-130"><span class="cite-bracket">[</span>130<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ReithBloughHong2015_62-9" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Octopamine" title="Octopamine">Octopamine</a><sup id="cite_ref-HitriHurdWyatt1994_60-3" class="reference"><a href="#cite_note-HitriHurdWyatt1994-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ParkerCubeddu1988_131-0" class="reference"><a href="#cite_note-ParkerCubeddu1988-131"><span class="cite-bracket">[</span>131<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Pemoline" title="Pemoline">Pemoline</a><sup id="cite_ref-PatrickMarkowitz1997_132-0" class="reference"><a href="#cite_note-PatrickMarkowitz1997-132"><span class="cite-bracket">[</span>132<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NishinoMignot1997_133-0" class="reference"><a href="#cite_note-NishinoMignot1997-133"><span class="cite-bracket">[</span>133<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-FullerPerryBymaster1978_134-0" class="reference"><a href="#cite_note-FullerPerryBymaster1978-134"><span class="cite-bracket">[</span>134<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Phenethylamine" title="Phenethylamine">Phenethylamine</a><sup id="cite_ref-ReithBloughHong2015_62-10" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ParkerCubeddu1988_131-1" class="reference"><a href="#cite_note-ParkerCubeddu1988-131"><span class="cite-bracket">[</span>131<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Phenmetrazine" title="Phenmetrazine">Phenmetrazine</a><sup id="cite_ref-RothmanBaumann2003_111-5" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Phentermine" title="Phentermine">Phentermine</a><sup id="cite_ref-HealGosdenSmith2014_76-15" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2003_111-6" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Phenylpropanolamine" title="Phenylpropanolamine">Phenylpropanolamine</a> (PPA)<sup id="cite_ref-RothmanBaumann2005_123-1" class="reference"><a href="#cite_note-RothmanBaumann2005-123"><span class="cite-bracket">[</span>123<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanVuPartilla2003_124-1" class="reference"><a href="#cite_note-RothmanVuPartilla2003-124"><span class="cite-bracket">[</span>124<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Pseudoephedrine" title="Pseudoephedrine">Pseudoephedrine</a><sup id="cite_ref-RothmanBaumann2005_123-2" class="reference"><a href="#cite_note-RothmanBaumann2005-123"><span class="cite-bracket">[</span>123<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanVuPartilla2003_124-2" class="reference"><a href="#cite_note-RothmanVuPartilla2003-124"><span class="cite-bracket">[</span>124<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Tryptamine" title="Tryptamine">Tryptamine</a><sup id="cite_ref-BloughLandavazoDecker2014_135-0" class="reference"><a href="#cite_note-BloughLandavazoDecker2014-135"><span class="cite-bracket">[</span>135<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-BloughLandavazoPartilla2014_118-1" class="reference"><a href="#cite_note-BloughLandavazoPartilla2014-118"><span class="cite-bracket">[</span>118<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Tyramine" title="Tyramine">Tyramine</a><sup id="cite_ref-RothmanBaumann2003_111-7" class="reference"><a href="#cite_note-RothmanBaumann2003-111"><span class="cite-bracket">[</span>111<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanBaumann2006_112-6" class="reference"><a href="#cite_note-RothmanBaumann2006-112"><span class="cite-bracket">[</span>112<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ParkerCubeddu1988_131-2" class="reference"><a href="#cite_note-ParkerCubeddu1988-131"><span class="cite-bracket">[</span>131<span class="cite-bracket">]</span></a></sup></li></ul> </div> <p>These agents are also known as substrate-type dopamine releasing agents and as DAT reversers.<sup id="cite_ref-HealGosdenSmith2014_76-16" class="reference"><a href="#cite_note-HealGosdenSmith2014-76"><span class="cite-bracket">[</span>76<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ReithBloughHong2015_62-11" class="reference"><a href="#cite_note-ReithBloughHong2015-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Allosteric_modulators">Allosteric modulators</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=17" title="Edit section: Allosteric modulators"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading4"><h4 id="Positive_allosteric_modulators">Positive allosteric modulators</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=18" title="Edit section: Positive allosteric modulators"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Apigenin" title="Apigenin">Apigenin</a><sup id="cite_ref-ZhaoQinWang2010_136-0" class="reference"><a href="#cite_note-ZhaoQinWang2010-136"><span class="cite-bracket">[</span>136<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Luteolin" title="Luteolin">Luteolin</a><sup id="cite_ref-ZhaoQinWang2010_136-1" class="reference"><a href="#cite_note-ZhaoQinWang2010-136"><span class="cite-bracket">[</span>136<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ZhangLiuLei2010_137-0" class="reference"><a href="#cite_note-ZhangLiuLei2010-137"><span class="cite-bracket">[</span>137<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/SoRI-9804" title="SoRI-9804">SoRI-9804</a> (SRI-9804)<sup id="cite_ref-SchmittRothmanReith2013_61-4" class="reference"><a href="#cite_note-SchmittRothmanReith2013-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AggarwalMortensen2023_77-2" class="reference"><a href="#cite_note-AggarwalMortensen2023-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanDerschCarroll2002_138-0" class="reference"><a href="#cite_note-RothmanDerschCarroll2002-138"><span class="cite-bracket">[</span>138<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=SoRI-20040&action=edit&redlink=1" class="new" title="SoRI-20040 (page does not exist)">SoRI-20040</a> (SRI-20040)<sup id="cite_ref-SchmittRothmanReith2013_61-5" class="reference"><a href="#cite_note-SchmittRothmanReith2013-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AggarwalMortensen2023_77-3" class="reference"><a href="#cite_note-AggarwalMortensen2023-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PariserPartillaDersch2008_139-0" class="reference"><a href="#cite_note-PariserPartillaDersch2008-139"><span class="cite-bracket">[</span>139<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanDerschAnanthan2009_140-0" class="reference"><a href="#cite_note-RothmanDerschAnanthan2009-140"><span class="cite-bracket">[</span>140<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading4"><h4 id="Negative_allosteric_modulators">Negative allosteric modulators</h4><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=19" title="Edit section: Negative allosteric modulators"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Armesocarb" title="Armesocarb">Armesocarb</a> (MLR-1019)<sup id="cite_ref-Macolino-KaneCiallellaLipinski2017_141-0" class="reference"><a href="#cite_note-Macolino-KaneCiallellaLipinski2017-141"><span class="cite-bracket">[</span>141<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NepalDasReith2023_82-2" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Al'tschuler2005_142-0" class="reference"><a href="#cite_note-Al'tschuler2005-142"><span class="cite-bracket">[</span>142<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a><sup id="cite_ref-BullingSchickerZhang2012_143-0" class="reference"><a href="#cite_note-BullingSchickerZhang2012-143"><span class="cite-bracket">[</span>143<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NepalDasReith2023_82-3" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-HarsingSershenLajtha1994_144-0" class="reference"><a href="#cite_note-HarsingSershenLajtha1994-144"><span class="cite-bracket">[</span>144<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-WellsLopezTanaka1999_145-0" class="reference"><a href="#cite_note-WellsLopezTanaka1999-145"><span class="cite-bracket">[</span>145<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=KM822&action=edit&redlink=1" class="new" title="KM822 (page does not exist)">KM822</a><sup id="cite_ref-AggarwalMortensen2023_77-4" class="reference"><a href="#cite_note-AggarwalMortensen2023-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NguyenChengLee2024_146-0" class="reference"><a href="#cite_note-NguyenChengLee2024-146"><span class="cite-bracket">[</span>146<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NepalDasReith2023_82-4" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AggarwalLiuRice2019_147-0" class="reference"><a href="#cite_note-AggarwalLiuRice2019-147"><span class="cite-bracket">[</span>147<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Mesocarb" title="Mesocarb">Mesocarb</a> (Sydnocarb; MLR-1017)<sup id="cite_ref-NepalDasReith2023_82-5" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-NguyenChengLee2024_146-1" class="reference"><a href="#cite_note-NguyenChengLee2024-146"><span class="cite-bracket">[</span>146<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AggarwalChengSalvino2021_148-0" class="reference"><a href="#cite_note-AggarwalChengSalvino2021-148"><span class="cite-bracket">[</span>148<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=MRS7292&action=edit&redlink=1" class="new" title="MRS7292 (page does not exist)">MRS7292</a><sup id="cite_ref-NepalDasReith2023_82-6" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ToshJanowskyEshleman2017_149-0" class="reference"><a href="#cite_note-ToshJanowskyEshleman2017-149"><span class="cite-bracket">[</span>149<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-SrivastavaNavratnaTosh2024_150-0" class="reference"><a href="#cite_note-SrivastavaNavratnaTosh2024-150"><span class="cite-bracket">[</span>150<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/SoRI-20041" title="SoRI-20041">SoRI-20041</a> (SRI-20041)<sup id="cite_ref-SchmittRothmanReith2013_61-6" class="reference"><a href="#cite_note-SchmittRothmanReith2013-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AggarwalMortensen2023_77-5" class="reference"><a href="#cite_note-AggarwalMortensen2023-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-PariserPartillaDersch2008_139-1" class="reference"><a href="#cite_note-PariserPartillaDersch2008-139"><span class="cite-bracket">[</span>139<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanDerschAnanthan2009_140-1" class="reference"><a href="#cite_note-RothmanDerschAnanthan2009-140"><span class="cite-bracket">[</span>140<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=SRI-29574&action=edit&redlink=1" class="new" title="SRI-29574 (page does not exist)">SRI-29574</a><sup id="cite_ref-AggarwalMortensen2023_77-6" class="reference"><a href="#cite_note-AggarwalMortensen2023-77"><span class="cite-bracket">[</span>77<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-RothmanAnanthanPartilla2015_151-0" class="reference"><a href="#cite_note-RothmanAnanthanPartilla2015-151"><span class="cite-bracket">[</span>151<span class="cite-bracket">]</span></a></sup></li> <li><a href="/w/index.php?title=SRI-31142&action=edit&redlink=1" class="new" title="SRI-31142 (page does not exist)">SRI-31142</a><sup id="cite_ref-NepalDasReith2023_82-7" class="reference"><a href="#cite_note-NepalDasReith2023-82"><span class="cite-bracket">[</span>82<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-MoerkeAnanthanBanks2018_152-0" class="reference"><a href="#cite_note-MoerkeAnanthanBanks2018-152"><span class="cite-bracket">[</span>152<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=20" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1184024115"><div class="div-col" style="column-width: 30em;"> <ul><li><a href="/wiki/Monoamine_transporter" title="Monoamine transporter">Monoamine transporter</a></li> <li><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">Norepinephrine transporter</a></li> <li><a href="/wiki/Serotonin_transporter" title="Serotonin transporter">Serotonin transporter</a></li> <li><a href="/wiki/Glutamate_transporter" title="Glutamate transporter">Glutamate transporter</a></li></ul></div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=21" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist reflist-columns references-column-width" style="column-width: 30em;"> <ol class="references"> <li 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href="https://pubmed.ncbi.nlm.nih.gov/27141430">27141430</a>. <q>Despite the challenges in determining synaptic vesicle pH, the proton gradient across the vesicle membrane is of fundamental importance for its function. Exposure of isolated catecholamine vesicles to protonophores collapses the pH gradient and rapidly redistributes transmitter from inside to outside the vesicle. ... Amphetamine and its derivatives like methamphetamine are weak base compounds that are the only widely used class of drugs known to elicit transmitter release by a non-exocytic mechanism. As substrates for both DAT and VMAT, amphetamines can be taken up to the cytosol and then sequestered in vesicles, where they act to collapse the vesicular pH gradient.</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Basal+Ganglia&rft.atitle=Striatal+dopamine+neurotransmission%3A+regulation+of+release+and+uptake&rft.volume=6&rft.issue=3&rft.pages=123-148&rft.date=2016-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4850498%23id-name%3DPMC&rft_id=info%3Apmid%2F27141430&rft_id=info%3Adoi%2F10.1016%2Fj.baga.2016.02.001&rft.aulast=Sulzer&rft.aufirst=D&rft.au=Cragg%2C+SJ&rft.au=Rice%2C+ME&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4850498&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-GIRK-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-GIRK_18-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFLedonneBerrettaDavoliRizzo2011" class="citation journal cs1">Ledonne A, Berretta N, Davoli A, Rizzo GR, Bernardi G, Mercuri NB (July 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131148">"Electrophysiological effects of trace amines on mesencephalic dopaminergic neurons"</a>. <i>Front. 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University of Paris. 28 January 2012<span class="reference-accessdate">. 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In this context, controlled double-blind studies in children are of interest, which showed positive effects of zinc [supplementation] on symptoms of ADHD [105,106]. It should be stated that at this time [supplementation] with zinc is not integrated in any ADHD treatment algorithm.</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Review+of+Neurotherapeutics&rft.atitle=SPECT+and+PET+of+the+dopamine+transporter+in+attention-deficit%2Fhyperactivity+disorder&rft.volume=8&rft.issue=4&rft.pages=611-25&rft.date=2008-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A24589993%23id-name%3DS2CID&rft_id=info%3Apmid%2F18416663&rft_id=info%3Adoi%2F10.1586%2F14737175.8.4.611&rft.aulast=Krause&rft.aufirst=J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-Review_-_cites_2002_amph-zinc_primary_study-36"><span class="mw-cite-backlink"><b><a href="#cite_ref-Review_-_cites_2002_amph-zinc_primary_study_36-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSulzer2011" class="citation journal cs1">Sulzer D (February 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065181">"How addictive drugs disrupt presynaptic dopamine neurotransmission"</a>. <i>Neuron</i>. <b>69</b> (4): 628–49. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.neuron.2011.02.010">10.1016/j.neuron.2011.02.010</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065181">3065181</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21338876">21338876</a>. <q>They did not confirm the predicted straightforward relationship between uptake and release, but rather that some compounds including AMPH were better releasers than substrates for uptake. Zinc, moreover, stimulates efflux of intracellular [3H]DA despite its concomitant inhibition of uptake (Scholze et al., 2002).</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=How+addictive+drugs+disrupt+presynaptic+dopamine+neurotransmission&rft.volume=69&rft.issue=4&rft.pages=628-49&rft.date=2011-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3065181%23id-name%3DPMC&rft_id=info%3Apmid%2F21338876&rft_id=info%3Adoi%2F10.1016%2Fj.neuron.2011.02.010&rft.aulast=Sulzer&rft.aufirst=D&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3065181&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-Primary_2002_amph-zinc_study-37"><span class="mw-cite-backlink">^ <a href="#cite_ref-Primary_2002_amph-zinc_study_37-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Primary_2002_amph-zinc_study_37-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFScholzeNørregaardSingerFreissmuth2002" class="citation journal cs1">Scholze P, Nørregaard L, Singer EA, Freissmuth M, Gether U, Sitte HH (June 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M112265200">"The role of zinc ions in reverse transport mediated by monoamine transporters"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (24): 21505–13. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M112265200">10.1074/jbc.M112265200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11940571">11940571</a>. <q>The human dopamine transporter (hDAT) contains an endogenous high affinity Zn<sup>2+</sup> binding site with three coordinating residues on its extracellular face (His193, His375, and Glu396). ... Although Zn<sup>2+</sup> inhibited uptake, Zn<sup>2+</sup> facilitated [3H]MPP+ release induced by amphetamine, MPP+, or K+-induced depolarization specifically at hDAT but not at the human serotonin and the norepinephrine transporter (hNET).</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=The+role+of+zinc+ions+in+reverse+transport+mediated+by+monoamine+transporters&rft.volume=277&rft.issue=24&rft.pages=21505-13&rft.date=2002-06&rft_id=info%3Adoi%2F10.1074%2Fjbc.M112265200&rft_id=info%3Apmid%2F11940571&rft.aulast=Scholze&rft.aufirst=P&rft.au=N%C3%B8rregaard%2C+L&rft.au=Singer%2C+EA&rft.au=Freissmuth%2C+M&rft.au=Gether%2C+U&rft.au=Sitte%2C+HH&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M112265200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-Zinc_and_PEA-38"><span class="mw-cite-backlink"><b><a href="#cite_ref-Zinc_and_PEA_38-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFScassellatiBonviciniFaraoneGennarelli2012" class="citation journal cs1">Scassellati C, Bonvicini C, Faraone SV, Gennarelli M (October 2012). 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(2015). "Stereochemistry of phenylpiracetam and its methyl derivative: improvement of the pharmacological profile". <i>Chemistry of Heterocyclic Compounds</i>. <b>51</b> (7): 601–606. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10593-015-1747-9">10.1007/s10593-015-1747-9</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0009-3122">0009-3122</a>. <q>Phenylpiracetam was originally designed as a nootropic drug for the sustenance and improvement of the physical condition and cognition abilities of Soviet space crews.2 Later, especially during the last decade, phenylpiracetam was introduced into general clinical practice in Russia and in some Eastern European countries. The possible target receptors and mechanisms for the acute activity of this drug remained unclear, until very recently it was found that (R)-phenylpiracetam (5) (MRZ-9547) is a selective dopamine transporter inhibitor that moderately stimulates striatal dopamine release.19</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Chemistry+of+Heterocyclic+Compounds&rft.atitle=Stereochemistry+of+phenylpiracetam+and+its+methyl+derivative%3A+improvement+of+the+pharmacological+profile&rft.volume=51&rft.issue=7&rft.pages=601-606&rft.date=2015&rft_id=info%3Adoi%2F10.1007%2Fs10593-015-1747-9&rft.issn=0009-3122&rft.aulast=Veinberg&rft.aufirst=G&rft.au=Vavers%2C+E&rft.au=Orlova%2C+N&rft.au=Kuznecovs%2C+J&rft.au=Domracheva%2C+I&rft.au=Vorona%2C+M&rft.au=Zvejniece%2C+L&rft.au=Dambrova%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-SommerDanyszRuss2014-104"><span class="mw-cite-backlink">^ <a href="#cite_ref-SommerDanyszRuss2014_104-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-SommerDanyszRuss2014_104-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSommerDanyszRussValastro2014" class="citation journal cs1">Sommer S, Danysz W, Russ H, Valastro B, Flik G, Hauber W (December 2014). "The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats". <i>The International Journal of Neuropsychopharmacology</i>. <b>17</b> (12): 2045–2056. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1017%2FS1461145714000996">10.1017/S1461145714000996</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24964269">24964269</a>. <q>Here, we tested the effects of MRZ-9547 [...], and its l-enantiomer MRZ-9546 on effort-related decision making in rats. The racemic form of these compounds referred to as phenotropil has been shown to stimulate motor activity in rats (Zvejniece et al., 2011) and enhance physical capacity and cognition in humans (Malykh and Sadaie, 2010). [...] MRZ-9547 turned out to be a DAT inhibitor as shown by displacement of binding of [125I] RTI-55 (IC50 = 4.82 ± 0.05 μM, n=3) to human recombinant DAT expressed in CHO-K1 cells and inhibition of DA uptake (IC50 = 14.5 ± 1.6 μM, n=2) in functional assays in the same cells. It inhibited norepinephrine transporter (NET) with an IC50 of 182 μM (one experiment in duplicate). The potencies for the l-enantiomer MRZ-9546 were as follows: DAT binding (Ki = 34.8 ± 14.8 μM, n=3), DAT function (IC50 = 65.5 ± 8.3 μM, n=2) and NET function (IC50 = 667 μM, one experiment performed in duplicate).</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+International+Journal+of+Neuropsychopharmacology&rft.atitle=The+dopamine+reuptake+inhibitor+MRZ-9547+increases+progressive+ratio+responding+in+rats&rft.volume=17&rft.issue=12&rft.pages=2045-2056&rft.date=2014-12&rft_id=info%3Adoi%2F10.1017%2FS1461145714000996&rft_id=info%3Apmid%2F24964269&rft.aulast=Sommer&rft.aufirst=S&rft.au=Danysz%2C+W&rft.au=Russ%2C+H&rft.au=Valastro%2C+B&rft.au=Flik%2C+G&rft.au=Hauber%2C+W&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-ZvejnieceSvalbeVavers2017-105"><span class="mw-cite-backlink"><b><a href="#cite_ref-ZvejnieceSvalbeVavers2017_105-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFZvejnieceSvalbeVaversMakrecka-Kuka2017" class="citation journal cs1">Zvejniece L, Svalbe B, Vavers E, Makrecka-Kuka M, Makarova E, Liepins V, et al. (September 2017). "S-phenylpiracetam, a selective DAT inhibitor, reduces body weight gain without influencing locomotor activity". <i>Pharmacology, Biochemistry, and Behavior</i>. <b>160</b>: 21–29. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pbb.2017.07.009">10.1016/j.pbb.2017.07.009</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28743458">28743458</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:13658335">13658335</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacology%2C+Biochemistry%2C+and+Behavior&rft.atitle=S-phenylpiracetam%2C+a+selective+DAT+inhibitor%2C+reduces+body+weight+gain+without+influencing+locomotor+activity&rft.volume=160&rft.pages=21-29&rft.date=2017-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A13658335%23id-name%3DS2CID&rft_id=info%3Apmid%2F28743458&rft_id=info%3Adoi%2F10.1016%2Fj.pbb.2017.07.009&rft.aulast=Zvejniece&rft.aufirst=L&rft.au=Svalbe%2C+B&rft.au=Vavers%2C+E&rft.au=Makrecka-Kuka%2C+M&rft.au=Makarova%2C+E&rft.au=Liepins%2C+V&rft.au=Kalvinsh%2C+I&rft.au=Liepinsh%2C+E&rft.au=Dambrova%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-StutzGolaniWitkin2019-106"><span class="mw-cite-backlink"><b><a href="#cite_ref-StutzGolaniWitkin2019_106-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFStutzGolaniWitkin2019" class="citation journal cs1">Stutz PV, Golani LK, Witkin JM (February 2019). "Animal models of fatigue in major depressive disorder". <i>Physiology & Behavior</i>. <b>199</b>: 300–305. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.physbeh.2018.11.042">10.1016/j.physbeh.2018.11.042</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30513290">30513290</a>. <q>In a study performed by Sommer et al. (2014), healthy rats treated with the selective dopamine transport (DAT) inhibitor MRZ-9547 (Fig. 1) chose high effort, high reward more often than their untreated matched controls. Unlike similar studies, however, depressive symptoms were not induced before treatment; rather, baseline healthy controls were compared to healthy rats treated with MRZ-9547. [...] In one study, the selective DAT inhibitor MRZ-9547 increased the number of lever presses more than untreated controls (Sommer et al., 2014). The investigators concluded that such effort-based "decision making in rodents could provide an animal model for motivational dysfunctions related to effort expenditure such as fatigue, e.g. in Parkinson's disease or major depression." Based upon the findings with MRZ-9547, they suggested that this drug mechanism might be a valuable therapeutic entity for fatigue in neurological and neuropsychiatric disorders. [...] A high effort bias been reported with bupropion (Randall et al., 2015), lisdexamfetamine (Yohn etal., 2016e), and the DA uptake blockers MRZ-9547 (Sommer et al., 2014), PRX-14040 (Fig. 1) (Yohn et al., 2016d) and GBR12909 (Fig. 1) (Yohn et al., 2016c).</q></cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Physiology+%26+Behavior&rft.atitle=Animal+models+of+fatigue+in+major+depressive+disorder&rft.volume=199&rft.pages=300-305&rft.date=2019-02&rft_id=info%3Adoi%2F10.1016%2Fj.physbeh.2018.11.042&rft_id=info%3Apmid%2F30513290&rft.aulast=Stutz&rft.aufirst=PV&rft.au=Golani%2C+LK&rft.au=Witkin%2C+JM&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-DekundyMelaHofmann2015-107"><span class="mw-cite-backlink"><b><a href="#cite_ref-DekundyMelaHofmann2015_107-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFDekundyMelaHofmannDanysz2015" class="citation journal cs1">Dekundy A, Mela F, Hofmann M, Danysz W (June 2015). "Effects of dopamine uptake inhibitor MRZ-9547 in animal models of Parkinson's disease". <i>Journal of Neural Transmission</i>. <b>122</b> (6): 809–818. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00702-014-1326-8">10.1007/s00702-014-1326-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25319446">25319446</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Neural+Transmission&rft.atitle=Effects+of+dopamine+uptake+inhibitor+MRZ-9547+in+animal+models+of+Parkinson%27s+disease&rft.volume=122&rft.issue=6&rft.pages=809-818&rft.date=2015-06&rft_id=info%3Adoi%2F10.1007%2Fs00702-014-1326-8&rft_id=info%3Apmid%2F25319446&rft.aulast=Dekundy&rft.aufirst=A&rft.au=Mela%2C+F&rft.au=Hofmann%2C+M&rft.au=Danysz%2C+W&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-NgoPlante2022-108"><span class="mw-cite-backlink"><b><a href="#cite_ref-NgoPlante2022_108-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFNgoPlante2022" class="citation journal cs1">Ngo Q, Plante DT (19 September 2022). "An Update on the Misuse and Abuse Potential of Pharmacological Treatments for Central Disorders of Hypersomnolence". <i>Current Sleep Medicine Reports</i>. <b>8</b> (4): 147–159. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs40675-022-00227-4">10.1007/s40675-022-00227-4</a>. <a href="/wiki/ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/2198-6401">2198-6401</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Sleep+Medicine+Reports&rft.atitle=An+Update+on+the+Misuse+and+Abuse+Potential+of+Pharmacological+Treatments+for+Central+Disorders+of+Hypersomnolence&rft.volume=8&rft.issue=4&rft.pages=147-159&rft.date=2022-09-19&rft_id=info%3Adoi%2F10.1007%2Fs40675-022-00227-4&rft.issn=2198-6401&rft.aulast=Ngo&rft.aufirst=Q&rft.au=Plante%2C+DT&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-YangGao2019-109"><span class="mw-cite-backlink"><b><a href="#cite_ref-YangGao2019_109-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYangGao2019" class="citation journal cs1">Yang J, Gao J (August 2019). "Solriamfetol for the treatment of excessive daytime sleepiness associated with narcolepsy". <i>Expert Rev Clin Pharmacol</i>. <b>12</b> (8): 723–728. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F17512433.2019.1632705">10.1080/17512433.2019.1632705</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31215815">31215815</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Rev+Clin+Pharmacol&rft.atitle=Solriamfetol+for+the+treatment+of+excessive+daytime+sleepiness+associated+with+narcolepsy&rft.volume=12&rft.issue=8&rft.pages=723-728&rft.date=2019-08&rft_id=info%3Adoi%2F10.1080%2F17512433.2019.1632705&rft_id=info%3Apmid%2F31215815&rft.aulast=Yang&rft.aufirst=J&rft.au=Gao%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> <li id="cite_note-MikelmanGuptaroySchmitt2018-110"><span class="mw-cite-backlink"><b><a href="#cite_ref-MikelmanGuptaroySchmitt2018_110-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFMikelmanGuptaroySchmittJones2018" class="citation journal cs1">Mikelman SR, Guptaroy B, Schmitt KC, Jones KT, Zhen J, Reith ME, et al. 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(November 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170971">"Interactions between Cocaine and the Putative Allosteric Dopamine Transporter Ligand SRI-31142"</a>. <i>J Pharmacol Exp Ther</i>. <b>367</b> (2): 222–233. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1124%2Fjpet.118.250902">10.1124/jpet.118.250902</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170971">6170971</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30150482">30150482</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=J+Pharmacol+Exp+Ther&rft.atitle=Interactions+between+Cocaine+and+the+Putative+Allosteric+Dopamine+Transporter+Ligand+SRI-31142&rft.volume=367&rft.issue=2&rft.pages=222-233&rft.date=2018-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6170971%23id-name%3DPMC&rft_id=info%3Apmid%2F30150482&rft_id=info%3Adoi%2F10.1124%2Fjpet.118.250902&rft.aulast=Moerke&rft.aufirst=MJ&rft.au=Ananthan%2C+S&rft.au=Banks%2C+ML&rft.au=Eltit%2C+JM&rft.au=Freitas%2C+KC&rft.au=Johnson%2C+AR&rft.au=Saini%2C+SK&rft.au=Steele%2C+TW&rft.au=Negus%2C+SS&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6170971&rfr_id=info%3Asid%2Fen.wikipedia.org%3ADopamine+transporter" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Dopamine_transporter&action=edit&section=22" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.nextbio.com/b/home/home.nb?q=dat1">Dopamine transporter-related Associations, Experiments, Publications and Clinical Trials</a></li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Dopamine+Transporter">Dopamine+Transporter</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q7K4Y6">Q7K4Y6</a></i> (Drosophila melanogaster Sodium-dependent dopamine transporter) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Membrane_proteins,_carrier_proteins:_membrane_transport_proteins_solute_carrier_(TC_2A)" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Solute_carrier_family" title="Template:Solute carrier family"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Solute_carrier_family" title="Template talk:Solute carrier family"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Solute_carrier_family" title="Special:EditPage/Template:Solute carrier family"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Membrane_proteins,_carrier_proteins:_membrane_transport_proteins_solute_carrier_(TC_2A)" style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_protein" title="Membrane protein">Membrane proteins</a>, <a href="/wiki/Carrier_protein" class="mw-redirect" title="Carrier protein">carrier proteins</a>: <a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">membrane transport proteins</a> <a href="/wiki/Solute_carrier_family" title="Solute carrier family">solute carrier</a> (<a href="/wiki/Transporter_Classification_Database#2.A.09Porters_(uniporters,_symporters,_antiporters)" title="Transporter Classification Database">TC 2A</a>)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="By_group" style="font-size:114%;margin:0 4em">By group</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC1–10" style="font-size:114%;margin:0 4em">SLC1–10</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(1):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Excitatory_amino-acid_transporter" class="mw-redirect" title="Excitatory amino-acid transporter">high affinity glutamate and neutral amino-acid transporter</a> <ul><li><a href="/wiki/SLC1A1" class="mw-redirect" title="SLC1A1">SLC1A1</a></li> <li><a href="/wiki/SLC1A2" class="mw-redirect" title="SLC1A2">2</a></li> <li><a href="/wiki/Glutamate_aspartate_transporter" class="mw-redirect" title="Glutamate aspartate transporter">3</a></li> <li><a href="/wiki/SLC1A4" class="mw-redirect" title="SLC1A4">4</a></li> <li><a href="/wiki/SLC1A5" class="mw-redirect" title="SLC1A5">5</a></li> <li><a href="/wiki/Excitatory_amino-acid_transporter_4" class="mw-redirect" title="Excitatory amino-acid transporter 4">6</a></li> <li><a href="/wiki/Excitatory_amino-acid_transporter_5" class="mw-redirect" title="Excitatory amino-acid transporter 5">7</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(2):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glucose_transporter" title="Glucose transporter">facilitative GLUT transporter</a> <ul><li><a href="/wiki/GLUT1" title="GLUT1">SLC2A1</a></li> <li><a href="/wiki/GLUT2" title="GLUT2">2</a></li> <li><a href="/wiki/GLUT3" title="GLUT3">3</a></li> <li><a href="/wiki/GLUT4" title="GLUT4">4</a></li> <li><a href="/wiki/GLUT5" title="GLUT5">5</a></li> <li><a href="/wiki/SLC2A6" title="SLC2A6">6</a></li> <li><a href="/wiki/SLC2A7" title="SLC2A7">7</a></li> <li><a href="/wiki/GLUT8" title="GLUT8">8</a></li> <li><a href="/wiki/SLC2A9" title="SLC2A9">9</a></li> <li><a href="/wiki/SLC2A10" title="SLC2A10">10</a></li> <li><a href="/wiki/SLC2A11" title="SLC2A11">11</a></li> <li><a href="/wiki/SLC2A12" title="SLC2A12">12</a></li> <li><a href="/wiki/SLC2A13" title="SLC2A13">13</a></li> <li><a href="/wiki/SLC2A14" title="SLC2A14">14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(3):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>heavy subunits of <a href="/wiki/Heterodimeric_amino-acid_transporter" title="Heterodimeric amino-acid transporter">heterodimeric amino-acid transporters</a> <ul><li><a href="/wiki/SLC3A1" class="mw-redirect" title="SLC3A1">SLC3A1</a></li> <li><a href="/wiki/SLC3A2" class="mw-redirect" title="SLC3A2">2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(4):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bicarbonate_transporter_protein" class="mw-redirect" title="Bicarbonate transporter protein">bicarbonate transporter</a> <ul><li><a href="/wiki/Band_3" class="mw-redirect" title="Band 3">SLC4A1</a></li> <li><a href="/wiki/SLC4A2" class="mw-redirect" title="SLC4A2">2</a></li> <li><a href="/wiki/SLC4A3" class="mw-redirect" title="SLC4A3">3</a></li> <li><a href="/wiki/SLC4A4" class="mw-redirect" title="SLC4A4">4</a></li> <li><a href="/wiki/SLC4A5" class="mw-redirect" title="SLC4A5">5</a></li> <li><a href="/wiki/SLC4A6" class="mw-redirect" title="SLC4A6">6</a></li> <li><a href="/wiki/SLC4A7" class="mw-redirect" title="SLC4A7">7</a></li> <li><a href="/wiki/SLC4A8" class="mw-redirect" title="SLC4A8">8</a></li> <li><a href="/w/index.php?title=SLC4A9&action=edit&redlink=1" class="new" title="SLC4A9 (page does not exist)">9</a></li> <li><a href="/w/index.php?title=SLC4A10&action=edit&redlink=1" class="new" title="SLC4A10 (page does not exist)">10</a></li> <li><a href="/wiki/SLC4A11" class="mw-redirect" title="SLC4A11">11</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(5):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium-glucose_transport_proteins" title="Sodium-glucose transport proteins">sodium glucose cotransporter</a> <ul><li><a href="/wiki/SLC5A1" class="mw-redirect" title="SLC5A1">SLC5A1</a></li> <li><a href="/wiki/SGLT2" class="mw-redirect" title="SGLT2">2</a></li> <li><a href="/wiki/SLC5A3" class="mw-redirect" title="SLC5A3">3</a></li> <li><a href="/wiki/SLC5A4" title="SLC5A4">4</a></li> <li><a href="/wiki/Sodium-iodide_symporter" class="mw-redirect" title="Sodium-iodide symporter">5</a></li> <li><a href="/wiki/SLC5A6" class="mw-redirect" title="SLC5A6">6</a></li> <li><a href="/wiki/Choline_transporter" title="Choline transporter">7</a></li> <li><a href="/wiki/SLC5A8" class="mw-redirect" title="SLC5A8">8</a></li> <li><a href="/w/index.php?title=SLC5A9&action=edit&redlink=1" class="new" title="SLC5A9 (page does not exist)">9</a></li> <li><a href="/w/index.php?title=SLC5A10&action=edit&redlink=1" class="new" title="SLC5A10 (page does not exist)">10</a></li> <li><a href="/w/index.php?title=SLC5A11&action=edit&redlink=1" class="new" title="SLC5A11 (page does not exist)">11</a></li> <li><a href="/w/index.php?title=SLC5A12&action=edit&redlink=1" class="new" title="SLC5A12 (page does not exist)">12</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(6):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium" title="Sodium">sodium</a>- and <a href="/wiki/Chloride" title="Chloride">chloride</a>- dependent <a href="/wiki/Sodium:neurotransmitter_symporter" class="mw-redirect" title="Sodium:neurotransmitter symporter">sodium:neurotransmitter symporters</a> <ul><li><a href="/wiki/GABA_transporter_1" class="mw-redirect" title="GABA transporter 1">SLC6A1</a></li> <li><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">SLC6A2</a></li> <li><a class="mw-selflink selflink">SLC6A3</a></li> <li><a href="/wiki/Serotonin_transporter" title="Serotonin transporter">SLC6A4</a></li> <li><a href="/wiki/SLC6A5" class="mw-redirect" title="SLC6A5">SLC6A5</a></li> <li><a href="/wiki/SLC6A6" class="mw-redirect" title="SLC6A6">SLC6A6</a></li> <li><a href="/w/index.php?title=SLC6A7&action=edit&redlink=1" class="new" title="SLC6A7 (page does not exist)">SLC6A7</a></li> <li><a href="/wiki/SLC6A8" class="mw-redirect" title="SLC6A8">SLC6A8</a></li> <li><a href="/wiki/SLC6A9" class="mw-redirect" title="SLC6A9">SLC6A9</a></li> <li><a href="/w/index.php?title=SLC6A10&action=edit&redlink=1" class="new" title="SLC6A10 (page does not exist)">SLC6A10</a></li> <li><a href="/wiki/SLC6A11" class="mw-redirect" title="SLC6A11">SLC6A11</a></li> <li><a href="/wiki/SLC6A12" class="mw-redirect" title="SLC6A12">SLC6A12</a></li> <li><a href="/wiki/SLC6A13" class="mw-redirect" title="SLC6A13">SLC6A13</a></li> <li><a href="/wiki/SLC6A14" title="SLC6A14">SLC6A14</a></li> <li><a href="/wiki/SLC6A15" class="mw-redirect" title="SLC6A15">SLC6A15</a></li> <li><a href="/w/index.php?title=SLC6A16&action=edit&redlink=1" class="new" title="SLC6A16 (page does not exist)">SLC6A16</a></li> <li><a href="/w/index.php?title=SLC6A17&action=edit&redlink=1" class="new" title="SLC6A17 (page does not exist)">SLC6A17</a></li> <li><a href="/wiki/SLC6A18" title="SLC6A18">SLC6A18</a></li> <li><a href="/wiki/SLC6A19" class="mw-redirect" title="SLC6A19">SLC6A19</a></li> <li><a href="/wiki/SLC6A20" title="SLC6A20">SLC6A20</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(7):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>cationic amino-acid transporter/glycoprotein-associated <ul><li><a href="/wiki/SLC7A1" class="mw-redirect" title="SLC7A1">SLC7A1</a></li> <li><a href="/wiki/SLC7A2" class="mw-redirect" title="SLC7A2">SLC7A2</a></li> <li><a href="/wiki/SLC7A3" class="mw-redirect" title="SLC7A3">SLC7A3</a></li> <li><a href="/wiki/SLC7A4" class="mw-redirect" title="SLC7A4">SLC7A4</a></li></ul></li> <li>glycoprotein-associated/light or catalytic subunits of <a href="/wiki/Heterodimeric_amino-acid_transporter" title="Heterodimeric amino-acid transporter">heterodimeric amino-acid transporters</a> <ul><li><a href="/wiki/CD98" title="CD98">SLC7A5</a></li> <li><a href="/wiki/SLC7A6" class="mw-redirect" title="SLC7A6">SLC7A6</a></li> <li><a href="/wiki/SLC7A7" class="mw-redirect" title="SLC7A7">SLC7A7</a></li> <li><a href="/wiki/SLC7A8" class="mw-redirect" title="SLC7A8">SLC7A8</a></li> <li><a href="/wiki/SLC7A9" class="mw-redirect" title="SLC7A9">SLC7A9</a></li> <li><a href="/wiki/SLC7A10" class="mw-redirect" title="SLC7A10">SLC7A10</a></li> <li><a href="/wiki/SLC7A11" class="mw-redirect" title="SLC7A11">SLC7A11</a></li> <li><a href="/w/index.php?title=SLC7A13&action=edit&redlink=1" class="new" title="SLC7A13 (page does not exist)">SLC7A13</a></li> <li><a href="/wiki/SLC7A14" title="SLC7A14">SLC7A14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(8):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Na<sup>+</sup>/Ca<sup>2+</sup> exchanger</a> <ul><li><a href="/wiki/SLC8A1" class="mw-redirect" title="SLC8A1">SLC8A1</a></li> <li><a href="/w/index.php?title=SLC8A2&action=edit&redlink=1" class="new" title="SLC8A2 (page does not exist)">SLC8A2</a></li> <li><a href="/w/index.php?title=SLC8A3&action=edit&redlink=1" class="new" title="SLC8A3 (page does not exist)">SLC8A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(9):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium%E2%80%93hydrogen_antiporter" title="Sodium–hydrogen antiporter">Na<sup>+</sup>/H<sup>+</sup> exchanger</a> <ul><li><a href="/wiki/SLC9A1" class="mw-redirect" title="SLC9A1">SLC9A1</a></li> <li><a href="/wiki/SLC9A2" class="mw-redirect" title="SLC9A2">SLC9A2</a></li> <li><a href="/wiki/SLC9A3" class="mw-redirect" title="SLC9A3">SLC9A3</a></li> <li><a href="/w/index.php?title=SLC9A4&action=edit&redlink=1" class="new" title="SLC9A4 (page does not exist)">SLC9A4</a></li> <li><a href="/wiki/SLC9A5" class="mw-redirect" title="SLC9A5">SLC9A5</a></li> <li><a href="/wiki/SLC9A6" class="mw-redirect" title="SLC9A6">SLC9A6</a></li> <li><a href="/w/index.php?title=SLC9A7&action=edit&redlink=1" class="new" title="SLC9A7 (page does not exist)">SLC9A7</a></li> <li><a href="/wiki/SLC9A8" class="mw-redirect" title="SLC9A8">SLC9A8</a></li> <li><a href="/w/index.php?title=SLC9A9&action=edit&redlink=1" class="new" title="SLC9A9 (page does not exist)">SLC9A9</a></li> <li><a href="/wiki/SLC9A10" class="mw-redirect" title="SLC9A10">SLC9A10</a></li> <li><a href="/wiki/SLC9A11" class="mw-redirect" title="SLC9A11">SLC9A11</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(10):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Sodium_bile_salt_cotransport&action=edit&redlink=1" class="new" title="Sodium bile salt cotransport (page does not exist)">sodium bile salt cotransport</a> <ul><li><a href="/wiki/SLC10A1" class="mw-redirect" title="SLC10A1">SLC10A1</a></li> <li><a href="/wiki/SLC10A2" class="mw-redirect" title="SLC10A2">SLC10A2</a></li> <li><a href="/wiki/SLC10A3" class="mw-redirect" title="SLC10A3">SLC10A3</a></li> <li><a href="/w/index.php?title=SLC10A4&action=edit&redlink=1" class="new" title="SLC10A4 (page does not exist)">SLC10A4</a></li> <li><a href="/w/index.php?title=SLC10A5&action=edit&redlink=1" class="new" title="SLC10A5 (page does not exist)">SLC10A5</a></li> <li><a href="/w/index.php?title=SLC10A6&action=edit&redlink=1" class="new" title="SLC10A6 (page does not exist)">SLC10A6</a></li> <li><a href="/wiki/SLC10A7" class="mw-redirect" title="SLC10A7">SLC10A7</a></li></ul></li> <li><a href="/wiki/SLC10A1" class="mw-redirect" title="SLC10A1">10A1</a></li> <li><a href="/wiki/SLC10A2" class="mw-redirect" title="SLC10A2">10A2</a></li> <li><a href="/wiki/SLC10A3" class="mw-redirect" title="SLC10A3">10A3</a></li> <li><a href="/wiki/SLC10A7" class="mw-redirect" title="SLC10A7">10A7</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC11–20" style="font-size:114%;margin:0 4em">SLC11–20</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(11):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Proton_coupled_metal_ion_transporter&action=edit&redlink=1" class="new" title="Proton coupled metal ion transporter (page does not exist)">proton coupled metal ion transporter</a> <ul><li><a href="/wiki/SLC11A1" class="mw-redirect" title="SLC11A1">SLC11A1</a></li> <li><a href="/wiki/SLC11A2" class="mw-redirect" title="SLC11A2">SLC11A2</a><a href="/wiki/Ferroportin" title="Ferroportin">11A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(12):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Electroneutral_cation-Cl" title="Electroneutral cation-Cl">electroneutral cation-Cl</a> cotransporter <ul><li><a href="/wiki/Na-K-Cl_cotransporter" class="mw-redirect" title="Na-K-Cl cotransporter">SLC12A1</a></li> <li><a href="/wiki/Na-K-Cl_cotransporter" class="mw-redirect" title="Na-K-Cl cotransporter">SLC12A2</a></li> <li><a href="/wiki/Sodium-chloride_symporter" title="Sodium-chloride symporter">SLC12A3</a></li> <li><a href="/wiki/Chloride_potassium_symporter_4" title="Chloride potassium symporter 4">SLC12A4</a></li> <li><a href="/wiki/Chloride_potassium_symporter_5" title="Chloride potassium symporter 5">SLC12A5</a></li> <li><a href="/wiki/SLC12A6" title="SLC12A6">SLC12A6</a></li> <li><a href="/wiki/SLC12A7" title="SLC12A7">SLC12A7</a></li> <li><a href="/wiki/SLC12A8" title="SLC12A8">SLC12A8</a></li> <li><a href="/wiki/SLC12A9" title="SLC12A9">SLC12A9</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(13):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Human_Na%2B-sulfate/carboxylate_cotransporter&action=edit&redlink=1" class="new" title="Human Na+-sulfate/carboxylate cotransporter (page does not exist)">human Na<sup>+</sup>-sulfate/carboxylate cotransporter</a> <ul><li><a href="/w/index.php?title=SLC13A1&action=edit&redlink=1" class="new" title="SLC13A1 (page does not exist)">SLC13A1</a></li> <li><a href="/wiki/SLC13A2" title="SLC13A2">SLC13A2</a></li> <li><a href="/wiki/SLC13A3" title="SLC13A3">SLC13A3</a></li> <li><a href="/w/index.php?title=SLC13A4&action=edit&redlink=1" class="new" title="SLC13A4 (page does not exist)">SLC13A4</a></li> <li><a href="/wiki/SLC13A5" title="SLC13A5">SLC13A5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(14):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Urea_transporter" title="Urea transporter">urea transporter</a> <ul><li><a href="/wiki/SLC14A1" class="mw-redirect" title="SLC14A1">SLC14A1</a></li> <li><a href="/wiki/SLC14A2" class="mw-redirect" title="SLC14A2">SLC14A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(15):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Proton_oligopeptide_cotransporter&action=edit&redlink=1" class="new" title="Proton oligopeptide cotransporter (page does not exist)">proton oligopeptide cotransporter</a> <ul><li><a href="/wiki/Peptide_transporter_1" title="Peptide transporter 1">SLC15A1</a></li> <li><a href="/wiki/SLC15A2" title="SLC15A2">SLC15A2</a></li> <li><a href="/w/index.php?title=SLC15A3&action=edit&redlink=1" class="new" title="SLC15A3 (page does not exist)">SLC15A3</a></li> <li><a href="/wiki/SLC15A4" title="SLC15A4">SLC15A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(16):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Monocarboxylate&action=edit&redlink=1" class="new" title="Monocarboxylate (page does not exist)">monocarboxylate</a> transporter <ul><li><a href="/wiki/Monocarboxylate_transporter_1" title="Monocarboxylate transporter 1">SLC16A1</a></li> <li><a href="/wiki/Monocarboxylate_transporter_8" title="Monocarboxylate transporter 8">SLC16A2</a></li> <li><a href="/wiki/Monocarboxylate_transporter_4" title="Monocarboxylate transporter 4">SLC16A3</a></li> <li><a href="/wiki/Monocarboxylate_transporter_5" title="Monocarboxylate transporter 5">SLC16A4</a></li> <li><a href="/wiki/SLC16A5" class="mw-redirect" title="SLC16A5">SLC16A5</a></li> <li><a href="/w/index.php?title=SLC16A6&action=edit&redlink=1" class="new" title="SLC16A6 (page does not exist)">SLC16A6</a></li> <li><a href="/wiki/Monocarboxylate_transporter_2" title="Monocarboxylate transporter 2">SLC16A7</a></li> <li><a href="/wiki/Monocarboxylate_transporter_3" title="Monocarboxylate transporter 3">SLC16A8</a></li> <li><a href="/wiki/Monocarboxylate_transporter_9" title="Monocarboxylate transporter 9">SLC16A9</a></li> <li><a href="/wiki/Monocarboxylate_transporter_10" title="Monocarboxylate transporter 10">SLC16A10</a></li> <li><a href="/wiki/SLC16A11" title="SLC16A11">SLC16A11</a></li> <li><a href="/w/index.php?title=SLC16A12&action=edit&redlink=1" class="new" title="SLC16A12 (page does not exist)">SLC16A12</a></li> <li><a href="/w/index.php?title=SLC16A13&action=edit&redlink=1" class="new" title="SLC16A13 (page does not exist)">SLC16A13</a></li> <li><a href="/w/index.php?title=SLC16A14&action=edit&redlink=1" class="new" title="SLC16A14 (page does not exist)">SLC16A14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(17):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vesicular_glutamate_transporter_1" title="Vesicular glutamate transporter 1">Vesicular glutamate transporter 1</a> <ul><li><a href="/wiki/SLC17A1" class="mw-redirect" title="SLC17A1">SLC17A1</a></li> <li><a href="/w/index.php?title=SLC17A2&action=edit&redlink=1" class="new" title="SLC17A2 (page does not exist)">SLC17A2</a></li> <li><a href="/wiki/SLC17A3" title="SLC17A3">SLC17A3</a></li> <li><a href="/w/index.php?title=SLC17A4&action=edit&redlink=1" class="new" title="SLC17A4 (page does not exist)">SLC17A4</a></li> <li><a href="/wiki/SLC17A5" class="mw-redirect" title="SLC17A5">SLC17A5</a></li> <li><a href="/w/index.php?title=SLC17A6&action=edit&redlink=1" class="new" title="SLC17A6 (page does not exist)">SLC17A6</a></li> <li><a href="/wiki/SLC17A7" class="mw-redirect" title="SLC17A7">SLC17A7</a></li> <li><a href="/wiki/SLC17A8" class="mw-redirect" title="SLC17A8">SLC17A8</a></li> <li><a href="/wiki/SLC17A9" title="SLC17A9">SLC17A9</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(18):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vesicular_monoamine_transporter" title="Vesicular monoamine transporter">vesicular monoamine transporter</a> <ul><li><a href="/wiki/VMAT1" class="mw-redirect" title="VMAT1">SLC18A1</a></li> <li><a href="/wiki/VMAT2" class="mw-redirect" title="VMAT2">SLC18A2</a></li> <li><a href="/wiki/Vesicular_acetylcholine_transporter" title="Vesicular acetylcholine transporter">SLC18A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(19):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Folate" title="Folate">folate</a>/<a href="/wiki/Thiamine" title="Thiamine">thiamine</a> transporter <ul><li><a href="/wiki/SLC19A1" class="mw-redirect" title="SLC19A1">SLC19A1</a></li> <li><a href="/wiki/SLC19A2" class="mw-redirect" title="SLC19A2">SLC19A2</a></li> <li><a href="/wiki/SLC19A3" class="mw-redirect" title="SLC19A3">SLC19A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(20):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Type_III_Na%2B-phosphate" class="mw-redirect" title="Type III Na+-phosphate">type III Na<sup>+</sup>-phosphate</a> cotransporter <ul><li><a href="/wiki/SLC20A1" title="SLC20A1">SLC20A1</a></li> <li><a href="/wiki/SLC20A2" title="SLC20A2">SLC20A2</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC21–30" style="font-size:114%;margin:0 4em">SLC21–30</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(21):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Organic_anion-transporting_polypeptide" class="mw-redirect" title="Organic anion-transporting polypeptide">Organic anion-transporting polypeptide</a> <ul><li><a href="/wiki/SLCO1A2" class="mw-redirect" title="SLCO1A2">SLCO1A2</a></li> <li><a href="/wiki/SLCO1B1" class="mw-redirect" title="SLCO1B1">SLCO1B1</a></li> <li><a href="/wiki/SLCO1B3" class="mw-redirect" title="SLCO1B3">SLCO1B3</a></li> <li><a href="/w/index.php?title=SLCO1B4&action=edit&redlink=1" class="new" title="SLCO1B4 (page does not exist)">SLCO1B4</a></li> <li><a href="/wiki/SLCO1C1" class="mw-redirect" title="SLCO1C1">SLCO1C1</a></li></ul></li> <li> <ul><li><a href="/wiki/SLCO2A1" class="mw-redirect" title="SLCO2A1">SLCO2A1</a></li> <li><a href="/wiki/SLCO2B1" class="mw-redirect" title="SLCO2B1">SLCO2B1</a></li></ul></li> <li> <ul><li><a href="/wiki/SLCO3A1" class="mw-redirect" title="SLCO3A1">SLCO3A1</a></li></ul></li> <li> <ul><li><a href="/wiki/SLCO4A1" class="mw-redirect" title="SLCO4A1">SLCO4A1</a></li> <li><a href="/w/index.php?title=SLCO4C1&action=edit&redlink=1" class="new" title="SLCO4C1 (page does not exist)">SLCO4C1</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLCO5A1&action=edit&redlink=1" class="new" title="SLCO5A1 (page does not exist)">SLCO5A1</a>(<a href="/w/index.php?title=SLCO6A1&action=edit&redlink=1" class="new" title="SLCO6A1 (page does not exist)">SLCO6A1</a>)</li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(22):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Organic_cation/anion/zwitterion_transporter" class="mw-redirect" title="Organic cation/anion/zwitterion transporter">organic cation/anion/zwitterion transporter</a> <ul><li><a href="/wiki/SLC22A1" title="SLC22A1">SLC22A1</a></li> <li><a href="/wiki/SLC22A2" title="SLC22A2">SLC22A2</a></li> <li><a href="/wiki/SLC22A3" title="SLC22A3">SLC22A3</a></li> <li><a href="/wiki/SLC22A4" title="SLC22A4">SLC22A4</a></li> <li><a href="/wiki/SLC22A5" title="SLC22A5">SLC22A5</a></li> <li><a href="/wiki/SLC22A6" class="mw-redirect" title="SLC22A6">SLC22A6</a></li> <li><a href="/wiki/SLC22A7" title="SLC22A7">SLC22A7</a></li> <li><a href="/wiki/SLC22A8" title="SLC22A8">SLC22A8</a></li> <li><a href="/wiki/SLC22A9" title="SLC22A9">SLC22A9</a></li> <li><a href="/wiki/SLC22A10" title="SLC22A10">SLC22A10</a></li> <li><a href="/wiki/SLC22A11" title="SLC22A11">SLC22A11</a></li> <li><a href="/wiki/SLC22A12" title="SLC22A12">SLC22A12</a></li> <li><a href="/wiki/SLC22A13" title="SLC22A13">SLC22A13</a></li> <li><a href="/wiki/SLC22A14" title="SLC22A14">SLC22A14</a></li> <li><a href="/wiki/SLC22A15" class="mw-redirect" title="SLC22A15">SLC22A15</a></li> <li><a href="/w/index.php?title=SLC22A16&action=edit&redlink=1" class="new" title="SLC22A16 (page does not exist)">SLC22A16</a></li> <li><a href="/w/index.php?title=SLC22A17&action=edit&redlink=1" class="new" title="SLC22A17 (page does not exist)">SLC22A17</a></li> <li><a href="/wiki/SLC22A18" title="SLC22A18">SLC22A18</a></li> <li><a href="/wiki/SLC22A19" class="mw-redirect" title="SLC22A19">SLC22A19</a></li> <li><a href="/w/index.php?title=SLC22A20&action=edit&redlink=1" class="new" title="SLC22A20 (page does not exist)">SLC22A20</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(23):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Na%2B-dependent_ascorbic_acid_transporter&action=edit&redlink=1" class="new" title="Na+-dependent ascorbic acid transporter (page does not exist)">Na+-dependent ascorbic acid transporter</a> <ul><li><a href="/wiki/SLC23A1" title="SLC23A1">SLC23A1</a></li> <li><a href="/wiki/SLC23A2" title="SLC23A2">SLC23A2</a></li> <li><a href="/w/index.php?title=SLC23A3&action=edit&redlink=1" class="new" title="SLC23A3 (page does not exist)">SLC23A3</a></li> <li><a href="/w/index.php?title=SLC23A4&action=edit&redlink=1" class="new" title="SLC23A4 (page does not exist)">SLC23A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(24):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Na%2B/(Ca2%2B-K%2B)_exchanger" class="mw-redirect" title="Na+/(Ca2+-K+) exchanger">Na<sup>+</sup>/(Ca<sup>2+</sup>-K<sup>+</sup>) exchanger</a> <ul><li><a href="/w/index.php?title=SLC24A1&action=edit&redlink=1" class="new" title="SLC24A1 (page does not exist)">SLC24A1</a></li> <li><a href="/w/index.php?title=SLC24A2&action=edit&redlink=1" class="new" title="SLC24A2 (page does not exist)">SLC24A2</a></li> <li><a href="/w/index.php?title=SLC24A3&action=edit&redlink=1" class="new" title="SLC24A3 (page does not exist)">SLC24A3</a></li> <li><a href="/wiki/SLC24A4" class="mw-redirect" title="SLC24A4">SLC24A4</a></li> <li><a href="/wiki/SLC24A5" class="mw-redirect" title="SLC24A5">SLC24A5</a></li> <li><a href="/w/index.php?title=SLC24A6&action=edit&redlink=1" class="new" title="SLC24A6 (page does not exist)">SLC24A6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(25):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mitochondrial_carrier" title="Mitochondrial carrier">mitochondrial carrier</a> <ul><li><a href="/wiki/SLC25A1" class="mw-redirect" title="SLC25A1">SLC25A1</a></li> <li><a href="/w/index.php?title=SLC25A2&action=edit&redlink=1" class="new" title="SLC25A2 (page does not exist)">SLC25A2</a></li> <li><a href="/wiki/SLC25A3" class="mw-redirect" title="SLC25A3">SLC25A3</a></li> <li><a href="/wiki/SLC25A4" class="mw-redirect" title="SLC25A4">SLC25A4</a></li> <li><a href="/wiki/SLC25A5" class="mw-redirect" title="SLC25A5">SLC25A5</a></li> <li><a href="/wiki/SLC25A6" class="mw-redirect" title="SLC25A6">SLC25A6</a></li> <li><a href="/wiki/Thermogenin" title="Thermogenin">SLC25A7</a></li> <li><a href="/wiki/SLC25A8" class="mw-redirect" title="SLC25A8">SLC25A8</a></li> <li><a href="/wiki/SLC25A9" class="mw-redirect" title="SLC25A9">SLC25A9</a></li> <li><a href="/wiki/SLC25A10" class="mw-redirect" title="SLC25A10">SLC25A10</a></li> <li><a href="/wiki/SLC25A11" class="mw-redirect" title="SLC25A11">SLC25A11</a></li> <li><a href="/wiki/SLC25A12" class="mw-redirect" title="SLC25A12">SLC25A12</a></li> <li><a href="/wiki/Citrin" title="Citrin">SLC25A13</a></li> <li><a href="/wiki/SLC25A14" class="mw-redirect" title="SLC25A14">SLC25A14</a></li> <li><a href="/wiki/Ornithine_translocase" title="Ornithine translocase">SLC25A15</a></li> <li><a href="/wiki/SLC25A16" title="SLC25A16">SLC25A16</a></li> <li><a href="/wiki/SLC25A17" class="mw-redirect" title="SLC25A17">SLC25A17</a></li> <li><a href="/w/index.php?title=SLC25A18&action=edit&redlink=1" class="new" title="SLC25A18 (page does not exist)">SLC25A18</a></li> <li><a href="/wiki/SLC25A19" class="mw-redirect" title="SLC25A19">SLC25A19</a></li> <li><a href="/wiki/Carnitine-acylcarnitine_translocase" title="Carnitine-acylcarnitine translocase">SLC25A20</a></li> <li><a href="/wiki/SLC25A21" class="mw-redirect" title="SLC25A21">SLC25A21</a></li> <li><a href="/wiki/SLC25A22" title="SLC25A22">SLC25A22</a></li> <li><a href="/w/index.php?title=SLC25A23&action=edit&redlink=1" class="new" title="SLC25A23 (page does not exist)">SLC25A23</a></li> <li><a href="/wiki/SLC25A24" class="mw-redirect" title="SLC25A24">SLC25A24</a></li> <li><a href="/w/index.php?title=SLC25A25&action=edit&redlink=1" class="new" title="SLC25A25 (page does not exist)">SLC25A25</a></li> <li><a href="/w/index.php?title=SLC25A26&action=edit&redlink=1" class="new" title="SLC25A26 (page does not exist)">SLC25A26</a></li> <li><a href="/wiki/SLC25A27" class="mw-redirect" title="SLC25A27">SLC25A27</a></li> <li><a href="/w/index.php?title=SLC25A28&action=edit&redlink=1" class="new" title="SLC25A28 (page does not exist)">SLC25A28</a></li> <li><a href="/wiki/SLC25A29" title="SLC25A29">SLC25A29</a></li> <li><a href="/w/index.php?title=SLC25A30&action=edit&redlink=1" class="new" title="SLC25A30 (page does not exist)">SLC25A30</a></li> <li><a href="/wiki/SLC25A31" class="mw-redirect" title="SLC25A31">SLC25A31</a></li> <li><a href="/wiki/SLC25A32" class="mw-redirect" title="SLC25A32">SLC25A32</a></li> <li><a href="/w/index.php?title=SLC25A33&action=edit&redlink=1" class="new" title="SLC25A33 (page does not exist)">SLC25A33</a></li> <li><a href="/w/index.php?title=SLC25A34&action=edit&redlink=1" class="new" title="SLC25A34 (page does not exist)">SLC25A34</a></li> <li><a href="/w/index.php?title=SLC25A35&action=edit&redlink=1" class="new" title="SLC25A35 (page does not exist)">SLC25A35</a></li> <li><a href="/w/index.php?title=SLC25A36&action=edit&redlink=1" class="new" title="SLC25A36 (page does not exist)">SLC25A36</a></li> <li><a href="/wiki/SLC25A37" class="mw-redirect" title="SLC25A37">SLC25A37</a></li> <li><a href="/wiki/SLC25A38" class="mw-redirect" title="SLC25A38">SLC25A38</a></li> <li><a href="/wiki/SLC25A39" title="SLC25A39">SLC25A39</a></li> <li><a href="/w/index.php?title=SLC25A40&action=edit&redlink=1" class="new" title="SLC25A40 (page does not exist)">SLC25A40</a></li> <li><a href="/w/index.php?title=SLC25A41&action=edit&redlink=1" class="new" title="SLC25A41 (page does not exist)">SLC25A41</a></li> <li><a href="/w/index.php?title=SLC25A42&action=edit&redlink=1" class="new" title="SLC25A42 (page does not exist)">SLC25A42</a></li> <li><a href="/w/index.php?title=SLC25A43&action=edit&redlink=1" class="new" title="SLC25A43 (page does not exist)">SLC25A43</a></li> <li><a href="/w/index.php?title=SLC25A44&action=edit&redlink=1" class="new" title="SLC25A44 (page does not exist)">SLC25A44</a></li> <li><a href="/w/index.php?title=SLC25A45&action=edit&redlink=1" class="new" title="SLC25A45 (page does not exist)">SLC25A45</a></li> <li><a href="/wiki/SLC25A46" title="SLC25A46">SLC25A46</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(26):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Multifunctional_anion_exchanger&action=edit&redlink=1" class="new" title="Multifunctional anion exchanger (page does not exist)">multifunctional anion exchanger</a> <ul><li><a href="/w/index.php?title=SLC26A1&action=edit&redlink=1" class="new" title="SLC26A1 (page does not exist)">SLC26A1</a></li> <li><a href="/wiki/SLC26A2" class="mw-redirect" title="SLC26A2">SLC26A2</a></li> <li><a href="/wiki/SLC26A3" class="mw-redirect" title="SLC26A3">SLC26A3</a></li> <li><a href="/wiki/Pendrin" title="Pendrin">SLC26A4</a></li> <li><a href="/wiki/SLC26A5" class="mw-redirect" title="SLC26A5">SLC26A5</a></li> <li><a href="/wiki/SLC26A6" title="SLC26A6">SLC26A6</a></li> <li><a href="/wiki/SLC26A7" class="mw-redirect" title="SLC26A7">SLC26A7</a></li> <li><a href="/wiki/SLC26A8" title="SLC26A8">SLC26A8</a></li> <li><a href="/w/index.php?title=SLC26A9&action=edit&redlink=1" class="new" title="SLC26A9 (page does not exist)">SLC26A9</a></li> <li><a href="/w/index.php?title=SLC26A10&action=edit&redlink=1" class="new" title="SLC26A10 (page does not exist)">SLC26A10</a></li> <li><a href="/w/index.php?title=SLC26A11&action=edit&redlink=1" class="new" title="SLC26A11 (page does not exist)">SLC26A11</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(27):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">fatty acid transport proteins</a> <ul><li><a href="/wiki/SLC27A1" class="mw-redirect" title="SLC27A1">SLC27A1</a></li> <li><a href="/wiki/SLC27A2" class="mw-redirect" title="SLC27A2">SLC27A2</a></li> <li><a href="/wiki/SLC27A3" title="SLC27A3">SLC27A3</a></li> <li><a href="/wiki/SLC27A4" class="mw-redirect" title="SLC27A4">SLC27A4</a></li> <li><a href="/wiki/SLC27A5" title="SLC27A5">SLC27A5</a></li> <li><a href="/wiki/SLC27A6" title="SLC27A6">SLC27A6</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(28):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Na%2B-coupled_nucleoside_transport&action=edit&redlink=1" class="new" title="Na+-coupled nucleoside transport (page does not exist)">Na<sup>+</sup>-coupled nucleoside transport</a> (<a href="/wiki/SLC28A1" class="mw-redirect" title="SLC28A1">SLC28A1</a> <ul><li><a href="/wiki/SLC28A2" class="mw-redirect" title="SLC28A2">SLC28A2</a></li> <li><a href="/w/index.php?title=SLC28A3&action=edit&redlink=1" class="new" title="SLC28A3 (page does not exist)">SLC28A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(29):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Facilitative_nucleoside_transporter&action=edit&redlink=1" class="new" title="Facilitative nucleoside transporter (page does not exist)">facilitative nucleoside transporter</a> <ul><li><a href="/wiki/SLC29A1" class="mw-redirect" title="SLC29A1">SLC29A1</a></li> <li><a href="/wiki/SLC29A2" class="mw-redirect" title="SLC29A2">SLC29A2</a></li> <li><a href="/w/index.php?title=SLC29A3&action=edit&redlink=1" class="new" title="SLC29A3 (page does not exist)">SLC29A3</a></li> <li><a href="/wiki/SLC29A4" class="mw-redirect" title="SLC29A4">SLC29A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(30):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Zinc_efflux" class="mw-redirect" title="Zinc efflux">zinc efflux</a> <ul><li><a href="/wiki/SLC30A1" class="mw-redirect" title="SLC30A1">SLC30A1</a></li> <li><a href="/w/index.php?title=SLC30A2&action=edit&redlink=1" class="new" title="SLC30A2 (page does not exist)">SLC30A2</a></li> <li><a href="/wiki/SLC30A3" class="mw-redirect" title="SLC30A3">SLC30A3</a></li> <li><a href="/wiki/SLC30A4" class="mw-redirect" title="SLC30A4">SLC30A4</a></li> <li><a href="/w/index.php?title=SLC30A5&action=edit&redlink=1" class="new" title="SLC30A5 (page does not exist)">SLC30A5</a></li> <li><a href="/w/index.php?title=SLC30A6&action=edit&redlink=1" class="new" title="SLC30A6 (page does not exist)">SLC30A6</a></li> <li><a href="/wiki/SLC30A7" class="mw-redirect" title="SLC30A7">SLC30A7</a></li> <li><a href="/wiki/SLC30A8" class="mw-redirect" title="SLC30A8">SLC30A8</a></li> <li><a href="/w/index.php?title=SLC30A9&action=edit&redlink=1" class="new" title="SLC30A9 (page does not exist)">SLC30A9</a></li> <li><a href="/wiki/SLC30A10" class="mw-redirect" title="SLC30A10">SLC30A10</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC31–40" style="font-size:114%;margin:0 4em">SLC31–40</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(31):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Copper" title="Copper">copper</a> transporter <ul><li><a href="/wiki/SLC31A1" class="mw-redirect" title="SLC31A1">SLC31A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(32):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vesicular_glutamate_transporter_1" title="Vesicular glutamate transporter 1">Vesicular glutamate transporter 1</a> <ul><li><a href="/wiki/SLC32A1" class="mw-redirect" title="SLC32A1">SLC32A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(33):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Acetyl-CoA" title="Acetyl-CoA">Acetyl-CoA</a> transporter <ul><li><a href="/wiki/SLC33A1" class="mw-redirect" title="SLC33A1">SLC33A1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(34):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Type_II_Na%2B-phosphate_cotransporter&action=edit&redlink=1" class="new" title="Type II Na+-phosphate cotransporter (page does not exist)">type II Na<sup>+</sup>-phosphate cotransporter</a> <ul><li><a href="/wiki/SLC34A1" class="mw-redirect" title="SLC34A1">SLC34A1</a></li> <li><a href="/wiki/SLC34A2" class="mw-redirect" title="SLC34A2">SLC34A2</a></li> <li><a href="/wiki/SLC34A3" class="mw-redirect" title="SLC34A3">SLC34A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(35):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Nucleoside-sugar_transporter&action=edit&redlink=1" class="new" title="Nucleoside-sugar transporter (page does not exist)">nucleoside-sugar transporter</a> <ul><li><a href="/wiki/SLC35A1" class="mw-redirect" title="SLC35A1">SLC35A1</a></li> <li><a href="/wiki/SLC35A2" class="mw-redirect" title="SLC35A2">SLC35A2</a></li> <li><a href="/w/index.php?title=SLC35A3&action=edit&redlink=1" class="new" title="SLC35A3 (page does not exist)">SLC35A3</a></li> <li><a href="/w/index.php?title=SLC35A4&action=edit&redlink=1" class="new" title="SLC35A4 (page does not exist)">SLC35A4</a></li> <li><a href="/w/index.php?title=SLC35A5&action=edit&redlink=1" class="new" title="SLC35A5 (page does not exist)">SLC35A5</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLC35B1&action=edit&redlink=1" class="new" title="SLC35B1 (page does not exist)">SLC35B1</a></li> <li><a href="/wiki/SLC35B2" class="mw-redirect" title="SLC35B2">SLC35B2</a></li> <li><a href="/w/index.php?title=SLC35B3&action=edit&redlink=1" class="new" title="SLC35B3 (page does not exist)">SLC35B3</a></li> <li><a href="/wiki/SLC35B4" class="mw-redirect" title="SLC35B4">SLC35B4</a></li></ul></li> <li> <ul><li><a href="/wiki/SLC35C1" class="mw-redirect" title="SLC35C1">SLC35C1</a></li> <li><a href="/wiki/SLC35C2" title="SLC35C2">SLC35C2</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLC35D1&action=edit&redlink=1" class="new" title="SLC35D1 (page does not exist)">SLC35D1</a></li> <li><a href="/w/index.php?title=SLC35D2&action=edit&redlink=1" class="new" title="SLC35D2 (page does not exist)">SLC35D2</a></li> <li><a href="/w/index.php?title=SLC35D3&action=edit&redlink=1" class="new" title="SLC35D3 (page does not exist)">SLC35D3</a></li></ul></li> <li> <ul><li><a href="/w/index.php?title=SLC35E1&action=edit&redlink=1" class="new" title="SLC35E1 (page does not exist)">SLC35E1</a></li> <li><a href="/w/index.php?title=SLC35E2&action=edit&redlink=1" class="new" title="SLC35E2 (page does not exist)">SLC35E2</a></li> <li><a href="/w/index.php?title=SLC35E3&action=edit&redlink=1" class="new" title="SLC35E3 (page does not exist)">SLC35E3</a></li> <li><a href="/w/index.php?title=SLC35E4&action=edit&redlink=1" class="new" title="SLC35E4 (page does not exist)">SLC35E4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(36):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proton-coupled_amino-acid_transporter" class="mw-redirect" title="Proton-coupled amino-acid transporter">proton-coupled amino-acid transporter</a> <ul><li><a href="/wiki/SLC36A1" class="mw-redirect" title="SLC36A1">SLC36A1</a></li> <li><a href="/wiki/SLC36A2" class="mw-redirect" title="SLC36A2">SLC36A2</a></li> <li><a href="/w/index.php?title=SLC36A3&action=edit&redlink=1" class="new" title="SLC36A3 (page does not exist)">SLC36A3</a></li> <li><a href="/w/index.php?title=SLC36A4&action=edit&redlink=1" class="new" title="SLC36A4 (page does not exist)">SLC36A4</a><a href="/wiki/SLC36A2" class="mw-redirect" title="SLC36A2">36A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(37):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Sugar-phosphate/phosphate_exchanger&action=edit&redlink=1" class="new" title="Sugar-phosphate/phosphate exchanger (page does not exist)">sugar-phosphate/phosphate exchanger</a> <ul><li><a href="/wiki/SLC37A1" class="mw-redirect" title="SLC37A1">SLC37A1</a></li> <li><a href="/wiki/SLC37A2" class="mw-redirect" title="SLC37A2">SLC37A2</a></li> <li><a href="/w/index.php?title=SLC37A3&action=edit&redlink=1" class="new" title="SLC37A3 (page does not exist)">SLC37A3</a></li> <li><a href="/wiki/SLC37A4" class="mw-redirect" title="SLC37A4">SLC37A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(38):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=System_A_%26_N,_sodium-coupled_neutral_amino-acid_transporter&action=edit&redlink=1" class="new" title="System A & N, sodium-coupled neutral amino-acid transporter (page does not exist)">System A & N, sodium-coupled neutral amino-acid transporter</a> <ul><li><a href="/wiki/SLC38A1" title="SLC38A1">SLC38A1</a></li> <li><a href="/wiki/SLC38A2" class="mw-redirect" title="SLC38A2">SLC38A2</a></li> <li><a href="/wiki/SLC38A3" class="mw-redirect" title="SLC38A3">SLC38A3</a></li> <li><a href="/w/index.php?title=SLC38A4&action=edit&redlink=1" class="new" title="SLC38A4 (page does not exist)">SLC38A4</a></li> <li><a href="/wiki/SLC38A5" title="SLC38A5">SLC38A5</a></li> <li><a href="/w/index.php?title=SLC38A6&action=edit&redlink=1" class="new" title="SLC38A6 (page does not exist)">SLC38A6</a></li> <li><a href="/wiki/SLC38A10" class="mw-redirect" title="SLC38A10">SLC38A10</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(39):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Metal_ion_transporter" class="mw-redirect" title="Metal ion transporter">metal ion transporter</a> <ul><li><a href="/wiki/SLC39A1" class="mw-redirect" title="SLC39A1">SLC39A1</a></li> <li><a href="/wiki/SLC39A2" class="mw-redirect" title="SLC39A2">SLC39A2</a></li> <li><a href="/wiki/SLC39A3" class="mw-redirect" title="SLC39A3">SLC39A3</a></li> <li><a href="/wiki/SLC39A4" class="mw-redirect" title="SLC39A4">SLC39A4</a></li> <li><a href="/w/index.php?title=SLC39A5&action=edit&redlink=1" class="new" title="SLC39A5 (page does not exist)">SLC39A5</a></li> <li><a href="/wiki/SLC39A6" class="mw-redirect" title="SLC39A6">SLC39A6</a></li> <li><a href="/wiki/SLC39A7" class="mw-redirect" title="SLC39A7">SLC39A7</a></li> <li><a href="/wiki/SLC39A8" class="mw-redirect" title="SLC39A8">SLC39A8</a></li> <li><a href="/wiki/SLC39A9" class="mw-redirect" title="SLC39A9">SLC39A9</a></li> <li><a href="/wiki/SLC39A10" class="mw-redirect" title="SLC39A10">SLC39A10</a></li> <li><a href="/wiki/SLC39A11" title="SLC39A11">SLC39A11</a></li> <li><a href="/wiki/SLC39A12" class="mw-redirect" title="SLC39A12">SLC39A12</a></li> <li><a href="/w/index.php?title=SLC39A13&action=edit&redlink=1" class="new" title="SLC39A13 (page does not exist)">SLC39A13</a></li> <li><a href="/w/index.php?title=SLC39A14&action=edit&redlink=1" class="new" title="SLC39A14 (page does not exist)">SLC39A14</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(40):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Basolateral_iron_transporter&action=edit&redlink=1" class="new" title="Basolateral iron transporter (page does not exist)">basolateral iron transporter</a> <ul><li><a href="/wiki/Ferroportin" title="Ferroportin">SLC40A1</a></li></ul></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLC41–48" style="font-size:114%;margin:0 4em">SLC41–48</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(41):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Magnesium_transporter_E" title="Magnesium transporter E">Magnesium transporter E</a> <ul><li><a href="/wiki/SLC41A1" title="SLC41A1">SLC41A1</a></li> <li><a href="/w/index.php?title=SLC41A2&action=edit&redlink=1" class="new" title="SLC41A2 (page does not exist)">SLC41A2</a></li> <li><a href="/wiki/SLC41A3" title="SLC41A3">SLC41A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(42):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ammonia_transporter" title="Ammonia transporter">Ammonia transporter</a> <ul><li><a href="/wiki/RHAG" title="RHAG">RhAG</a></li> <li><a href="/wiki/RHBG" title="RHBG">RhBG</a></li> <li><a href="/wiki/RHCG" title="RHCG">RhCG</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(43):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Na%2B-independent,_system-L_like_amino-acid_transporter&action=edit&redlink=1" class="new" title="Na+-independent, system-L like amino-acid transporter (page does not exist)">Na<sup>+</sup>-independent, system-L like amino-acid transporter</a> <ul><li><a href="/wiki/SLC43A1" class="mw-redirect" title="SLC43A1">SLC43A1</a></li> <li><a href="/w/index.php?title=SLC43A2&action=edit&redlink=1" class="new" title="SLC43A2 (page does not exist)">SLC43A2</a></li> <li><a href="/w/index.php?title=SLC43A3&action=edit&redlink=1" class="new" title="SLC43A3 (page does not exist)">SLC43A3</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(44):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Choline-like_transporter&action=edit&redlink=1" class="new" title="Choline-like transporter (page does not exist)">Choline-like transporter</a> <ul><li><a href="/wiki/SLC44A1" class="mw-redirect" title="SLC44A1">SLC44A1</a></li> <li><a href="/wiki/SLC44A2" class="mw-redirect" title="SLC44A2">SLC44A2</a></li> <li><a href="/w/index.php?title=SLC44A3&action=edit&redlink=1" class="new" title="SLC44A3 (page does not exist)">SLC44A3</a></li> <li><a href="/wiki/SLC44A4" class="mw-redirect" title="SLC44A4">SLC44A4</a></li> <li><a href="/w/index.php?title=SLC44A5&action=edit&redlink=1" class="new" title="SLC44A5 (page does not exist)">SLC44A5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(45):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Putative_sugar_transporter&action=edit&redlink=1" class="new" title="Putative sugar transporter (page does not exist)">Putative sugar transporter</a> <ul><li><a href="/wiki/SLC45A1" title="SLC45A1">SLC45A1</a></li> <li><a href="/wiki/SLC45A2" class="mw-redirect" title="SLC45A2">SLC45A2</a></li> <li><a href="/w/index.php?title=SLC54A3&action=edit&redlink=1" class="new" title="SLC54A3 (page does not exist)">SLC54A3</a></li> <li><a href="/wiki/SLC45A4" title="SLC45A4">SLC45A4</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(46):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Folate_transporter&action=edit&redlink=1" class="new" title="Folate transporter (page does not exist)">Folate transporter</a> <ul><li><a href="/wiki/SLC46A1" class="mw-redirect" title="SLC46A1">SLC46A1</a></li> <li><a href="/w/index.php?title=SLC46A2&action=edit&redlink=1" class="new" title="SLC46A2 (page does not exist)">SLC46A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(47):</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Multi-antimicrobial_extrusion_protein" title="Multi-antimicrobial extrusion protein">multidrug and toxin extrusion</a> <ul><li><a href="/wiki/SLC47A1" class="mw-redirect" title="SLC47A1">SLC47A1</a></li> <li><a href="/wiki/SLC47A2" class="mw-redirect" title="SLC47A2">SLC47A2</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:right; background-color: AntiqueWhite;">(48):</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Heme_transporter" title="Heme transporter">Heme transporter</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="text-align:left; background-color: AntiqueWhite;"><div id="SLCO1–4" style="font-size:114%;margin:0 4em">SLCO1–4</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align:left;"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SLCO1A2" class="mw-redirect" title="SLCO1A2">O1A2</a></li> <li><a href="/wiki/SLCO1B1" class="mw-redirect" title="SLCO1B1">O1B1</a></li> <li><a href="/wiki/SLCO1B3" class="mw-redirect" title="SLCO1B3">O1B3</a></li> <li><a href="/wiki/SLCO2B1" class="mw-redirect" title="SLCO2B1">O2B1</a></li> <li><a href="/wiki/SLCO3A1" class="mw-redirect" title="SLCO3A1">O431</a></li> <li><a href="/wiki/SLCO4A1" class="mw-redirect" title="SLCO4A1">O4A1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background-color: AntiqueWhite;"><div id="Ion_pumps" style="font-size:114%;margin:0 4em"><a href="/wiki/Ion_transporter" title="Ion transporter">Ion pumps</a></div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Symporter" title="Symporter">Symporter</a>, <a href="/wiki/Cotransporter" title="Cotransporter">Cotransporter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Na-K-Cl_cotransporter" class="mw-redirect" title="Na-K-Cl cotransporter">Na<sup>+</sup>/K<sup>+</sup>,Cl<sup>−</sup></a></li> <li><a href="/wiki/Sodium/phosphate_cotransporter" title="Sodium/phosphate cotransporter">Na<sup>+</sup>/P<sub>i</sub>3</a></li> <li><a href="/wiki/Sodium-chloride_symporter" title="Sodium-chloride symporter">Na<sup>+</sup>/Cl<sup>−</sup></a></li> <li><a href="/wiki/Sodium-glucose_transport_proteins" title="Sodium-glucose transport proteins">Na<sup>+</sup>/glucose</a></li> <li><a href="/wiki/Sodium-iodide_symporter" class="mw-redirect" title="Sodium-iodide symporter">Na<sup>+</sup>/I<sup>−</sup></a></li> <li><a href="/wiki/Chloride_potassium_symporter" title="Chloride potassium symporter">Cl<sup>−</sup>/K<sup>+</sup></a> <ul><li><a href="/wiki/Chloride_potassium_symporter_4" title="Chloride potassium symporter 4">4</a></li> <li><a href="/wiki/Chloride_potassium_symporter_5" title="Chloride potassium symporter 5">5</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite"><a href="/wiki/Antiporter" title="Antiporter">Antiporter (exchanger)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Sodium%E2%80%93hydrogen_antiporter" title="Sodium–hydrogen antiporter">Na<sup>+</sup>/H<sup>+</sup></a></li> <li><a href="/wiki/Sodium-calcium_exchanger" title="Sodium-calcium exchanger">Na<sup>+</sup>/Ca<sup>2+</sup></a> <ul><li><a href="/wiki/Potassium-dependent_sodium-calcium_exchanger" title="Potassium-dependent sodium-calcium exchanger">Na<sup>+</sup>/(Ca<sup>2+</sup>-K<sup>+</sup></a>) - <a href="/wiki/Band_3" class="mw-redirect" title="Band 3">Cl<sup>−</sup>/<span class="chemf nowrap">HCO<span class="nowrap"><span style="display:inline-block;margin-bottom:-0.3em;vertical-align:-0.4em;line-height:1em;font-size:80%;text-align:left"><sup style="font-size:inherit;line-height:inherit;vertical-align:baseline">−</sup><br /><sub style="font-size:inherit;line-height:inherit;vertical-align:baseline">3</sub></span></span></span> (Band 3)</a></li></ul></li> <li><a href="/wiki/Cl-formate_exchanger" class="mw-redirect" title="Cl-formate exchanger">Cl<sup>−</sup>-formate</a></li> <li><a href="/wiki/Cl-oxalate_exchanger" title="Cl-oxalate exchanger">Cl<sup>−</sup>-oxalate</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2" style="background-color: AntiqueWhite; padding: 0px;"><div><i>see also <a href="/wiki/Template:Solute_carrier_disorders" title="Template:Solute carrier disorders">solute carrier disorders</a></i></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Membrane_transport_protein:_neurotransmitter_transporters_(TC_2.A.1.2)" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Neurotransmitter_transporters" title="Template:Neurotransmitter transporters"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Neurotransmitter_transporters" title="Template talk:Neurotransmitter transporters"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Neurotransmitter_transporters" title="Special:EditPage/Template:Neurotransmitter transporters"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Membrane_transport_protein:_neurotransmitter_transporters_(TC_2.A.1.2)" style="font-size:114%;margin:0 4em"><a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">Membrane transport protein</a>: <a href="/wiki/Neurotransmitter_transporter" title="Neurotransmitter transporter">neurotransmitter transporters</a> (TC 2.A.1.2)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Vesicular</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vesicular_monoamine_transporter" title="Vesicular monoamine transporter">Vesicular monoamine</a> <ul><li><a href="/wiki/Vesicular_monoamine_transporter_1" title="Vesicular monoamine transporter 1">VMAT1</a></li> <li><a href="/wiki/Vesicular_monoamine_transporter_2" title="Vesicular monoamine transporter 2">VMAT2</a></li></ul></li> <li><a href="/wiki/Vesicular_acetylcholine_transporter" title="Vesicular acetylcholine transporter">Vesicular acetylcholine</a></li> <li><a href="/wiki/Excitatory_amino-acid_transporter#VGLUTs" class="mw-redirect" title="Excitatory amino-acid transporter">Vesicular glutamate</a></li> <li><a href="/wiki/SLC32A1" class="mw-redirect" title="SLC32A1">Vesicular GABA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">Other</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Monoamine_transporter" title="Monoamine transporter">Monoamine</a> <ul><li><a class="mw-selflink selflink">DAT</a></li> <li><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">NET</a></li> <li><a href="/wiki/Serotonin_transporter" title="Serotonin transporter">SERT</a></li> <li><a href="/wiki/Plasma_membrane_monoamine_transporter" title="Plasma membrane monoamine transporter">PMAT</a></li></ul></li> <li><a href="/wiki/Excitatory_amino-acid_transporter#EAATs" class="mw-redirect" title="Excitatory amino-acid transporter">Excitatory amino-acid transporter</a></li> <li><a href="/wiki/GABA_transporter" title="GABA transporter">GABA transporter</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Monoamine_reuptake_inhibitors" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Monoamine_reuptake_inhibitors" title="Template:Monoamine reuptake inhibitors"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Monoamine_reuptake_inhibitors" title="Template talk:Monoamine reuptake inhibitors"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Monoamine_reuptake_inhibitors" title="Special:EditPage/Template:Monoamine reuptake inhibitors"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Monoamine_reuptake_inhibitors" style="font-size:114%;margin:0 4em"><a href="/wiki/Monoamine_reuptake_inhibitor" title="Monoamine reuptake inhibitor">Monoamine reuptake inhibitors</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a class="mw-selflink selflink"><abbr title="Dopamine transporter">DAT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Dopamine transporter</span><br /><small>(<a href="/wiki/Dopamine_reuptake_inhibitors" class="mw-redirect" title="Dopamine reuptake inhibitors"><abbr title="Dopamine reuptake inhibitors">DRIs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Dopamine reuptake inhibitors</span>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Piperazines:</i> <a href="/wiki/DBL-583" title="DBL-583">DBL-583</a></li> <li><a href="/wiki/GBR-12783" title="GBR-12783">GBR-12783</a></li> <li><a href="/wiki/GBR-12935" title="GBR-12935">GBR-12935</a></li> <li><a href="/wiki/GBR-13069" title="GBR-13069">GBR-13069</a></li> <li><a href="/wiki/GBR-13098" title="GBR-13098">GBR-13098</a></li> <li><a href="/wiki/JJC8-088" title="JJC8-088">JJC8-088</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Vanoxerine" title="Vanoxerine">Vanoxerine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Piperidines:</i> <a href="/wiki/4-Fluoropethidine" title="4-Fluoropethidine">4-Fluoropethidine</a></li> <li><a href="/wiki/Benocyclidine" title="Benocyclidine">Benocyclidine (BTCP)</a></li> <li><a href="/wiki/Desoxypipradrol" title="Desoxypipradrol">Desoxypipradrol</a></li> <li><a href="/wiki/Dexmethylphenidate" title="Dexmethylphenidate">Dexmethylphenidate</a></li> <li><a href="/wiki/Difemetorex" title="Difemetorex">Difemetorex</a></li> <li><a href="/wiki/Ethylphenidate" title="Ethylphenidate">Ethylphenidate</a></li> <li><a href="/wiki/HDMP-28" title="HDMP-28">HDMP-28</a></li> <li><a href="/wiki/Methylphenidate" title="Methylphenidate">Methylphenidate</a></li> <li><a href="/wiki/Pethidine" title="Pethidine">Pethidine (meperidine)</a></li> <li><a href="/wiki/Phencyclidine" title="Phencyclidine">Phencyclidine</a></li> <li><a href="/wiki/Pipradrol" title="Pipradrol">Pipradrol</a></li> <li><a href="/wiki/Serdexmethylphenidate" title="Serdexmethylphenidate">Serdexmethylphenidate</a></li> <li><a href="/wiki/Tenocyclidine" title="Tenocyclidine">Tenocyclidine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Pyrrolidines:</i> <a href="/wiki/Diphenylprolinol" title="Diphenylprolinol">Diphenylprolinol</a></li> <li><a href="/wiki/Methylenedioxypyrovalerone" title="Methylenedioxypyrovalerone">MDPV</a></li> <li><a href="/wiki/Naphyrone" title="Naphyrone">Naphyrone</a></li> <li><a href="/wiki/Prolintane" title="Prolintane">Prolintane</a></li> <li><a href="/wiki/Pyrovalerone" title="Pyrovalerone">Pyrovalerone</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Tropanes:</i> <a href="/wiki/Altropane" title="Altropane">Altropane</a></li> <li><a href="/wiki/Benzatropine" title="Benzatropine">Benzatropine (benztropine)</a></li> <li><a href="/wiki/Brasofensine" title="Brasofensine">Brasofensine</a></li> <li><a href="/wiki/WIN_35428" class="mw-redirect" title="WIN 35428">CFT</a></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a></li> <li><a href="/wiki/Dichloropane" title="Dichloropane">Dichloropane</a></li> <li><a href="/wiki/Difluoropine" title="Difluoropine">Difluoropine</a></li> <li><a href="/wiki/Etybenzatropine" title="Etybenzatropine">Etybenzatropine (ethybenztropine)</a></li> <li><a href="/wiki/FE-%CE%B2-CPPIT" title="FE-β-CPPIT">FE-β-CPPIT</a></li> <li><a href="/wiki/FP-%CE%B2-CPPIT" title="FP-β-CPPIT">FP-β-CPPIT</a></li> <li><a href="/wiki/Ioflupane_(123I)" title="Ioflupane (123I)">Ioflupane (<sup>123</sup>I)</a></li> <li><a href="/wiki/RTI-55" title="RTI-55">RTI-55</a></li> <li><a href="/wiki/RTI-112" title="RTI-112">RTI-112</a></li> <li><a href="/wiki/RTI-113" title="RTI-113">RTI-113</a></li> <li><a href="/wiki/RTI-121" title="RTI-121">RTI-121</a></li> <li><a href="/wiki/RTI-126" title="RTI-126">RTI-126</a></li> <li><a href="/wiki/RTI-150" title="RTI-150">RTI-150</a></li> <li><a href="/wiki/RTI-177" title="RTI-177">RTI-177</a></li> <li><a href="/wiki/RTI-229" title="RTI-229">RTI-229</a></li> <li><a href="/wiki/(-)-2%CE%B2-(3-(4-Methylphenyl)isoxazol-5-yl)-3%CE%B2-(4-chlorophenyl)tropane" class="mw-redirect" title="(-)-2β-(3-(4-Methylphenyl)isoxazol-5-yl)-3β-(4-chlorophenyl)tropane">RTI-336</a></li> <li><a href="/wiki/Tesofensine" title="Tesofensine">Tesofensine</a></li> <li><a href="/wiki/Troparil" title="Troparil">Troparil</a></li> <li><a href="/wiki/Tropoxane" title="Tropoxane">Tropoxane</a></li> <li><a href="/wiki/2%CE%B2-Propanoyl-3%CE%B2-(4-tolyl)-tropane" title="2β-Propanoyl-3β-(4-tolyl)-tropane">WF-11</a></li> <li><a href="/wiki/2%CE%B2-Propanoyl-3%CE%B2-(2-naphthyl)-tropane" title="2β-Propanoyl-3β-(2-naphthyl)-tropane">WF-23</a></li> <li><a href="/wiki/2-Propanoyl-3-(4-isopropylphenyl)-tropane" title="2-Propanoyl-3-(4-isopropylphenyl)-tropane">WF-31</a></li> <li><a href="/wiki/2%CE%B1-(Propanoyl)-3%CE%B2-(2-(6-methoxynaphthyl))-tropane" title="2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane">WF-33</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Others:</i> <a href="/wiki/Adrafinil" title="Adrafinil">Adrafinil</a></li> <li><a href="/wiki/Amifitadine" class="mw-redirect" title="Amifitadine">Amifitadine</a></li> <li><a href="/wiki/Armodafinil" title="Armodafinil">Armodafinil</a></li> <li><a href="/wiki/Amfonelic_acid" title="Amfonelic acid">Amfonelic acid</a></li> <li><a href="/wiki/Amineptine" title="Amineptine">Amineptine</a></li> <li><a href="/wiki/Ansofaxine" title="Ansofaxine">Ansofaxine</a></li> <li><a href="/wiki/Butyltolylquinuclidine" title="Butyltolylquinuclidine">BTQ</a></li> <li><a href="/wiki/BTS_74,398" title="BTS 74,398">BTS 74,398</a></li> <li><a href="/wiki/Bupropion" title="Bupropion">Bupropion</a></li> <li><i><a href="/wiki/Chaenomeles_speciosa" title="Chaenomeles speciosa">Chaenomeles speciosa</a></i></li> <li><a href="/wiki/Ciclazindol" title="Ciclazindol">Ciclazindol</a></li> <li><a href="/wiki/Dasotraline" title="Dasotraline">Dasotraline</a></li> <li><a href="/wiki/Desmethylsertraline" title="Desmethylsertraline">Desmethylsertraline</a></li> <li><a href="/wiki/Desmethylsibutramine" title="Desmethylsibutramine">Desmethylsibutramine (BTS-54354)</a></li> <li><a href="/wiki/Diclofensine" title="Diclofensine">Diclofensine</a></li> <li><a href="/wiki/Didesmethylsibutramine" title="Didesmethylsibutramine">Didesmethylsibutramine (BTS-54505)</a></li> <li><a href="/wiki/Dimethocaine" title="Dimethocaine">Dimethocaine</a></li> <li><a href="/wiki/Diphenylpyraline" title="Diphenylpyraline">Diphenylpyraline</a></li> <li><a href="/wiki/Dizocilpine" title="Dizocilpine">Dizocilpine (MK-801)</a></li> <li><a href="/wiki/DOV-102,677" title="DOV-102,677">DOV-102,677</a></li> <li><a href="/wiki/DOV-216,303" title="DOV-216,303">DOV-216,303</a></li> <li><a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/Ephenidine" title="Ephenidine">Ephenidine</a></li> <li><a href="/wiki/Esketamine" title="Esketamine">Esketamine</a></li> <li><a href="/wiki/EXP-561" title="EXP-561">EXP-561</a></li> <li><a href="/wiki/Fencamfamin" title="Fencamfamin">Fencamfamin</a></li> <li><a href="/wiki/Fezolamine" title="Fezolamine">Fezolamine</a></li> <li><a href="/wiki/Fluorenol" title="Fluorenol">Fluorenol</a></li> <li><a href="/wiki/GYKI-52895" class="mw-redirect" title="GYKI-52895">GYKI-52895</a></li> <li><a href="/wiki/Hydroxybupropion" title="Hydroxybupropion">Hydroxybupropion</a></li> <li><a href="/wiki/Indatraline" title="Indatraline">Indatraline</a></li> <li><a href="/wiki/Ketamine" title="Ketamine">Ketamine</a></li> <li><a href="/wiki/Lefetamine" title="Lefetamine">Lefetamine</a></li> <li><a href="/wiki/Levophacetoperane" title="Levophacetoperane">Levophacetoperane</a></li> <li><a href="/wiki/Liafensine" title="Liafensine">Liafensine</a></li> <li><a href="/wiki/LR-5182" title="LR-5182">LR-5182</a></li> <li><a href="/wiki/Manifaxine" title="Manifaxine">Manifaxine</a></li> <li><a href="/wiki/Mazindol" title="Mazindol">Mazindol</a></li> <li><a href="/wiki/Medifoxamine" title="Medifoxamine">Medifoxamine</a></li> <li><a href="/wiki/Mesocarb" title="Mesocarb">Mesocarb</a></li> <li><a href="/wiki/Metaphit" title="Metaphit">Metaphit</a></li> <li><a href="/wiki/MIN-117" title="MIN-117">MIN-117 (WF-516)</a></li> <li><a href="/wiki/Modafinil" title="Modafinil">Modafinil</a></li> <li><a href="/wiki/Nefopam" title="Nefopam">Nefopam</a></li> <li><a href="/wiki/Nomifensine" title="Nomifensine">Nomifensine</a></li> <li><a href="/wiki/NS-2359" title="NS-2359">NS-2359</a></li> <li><a href="/wiki/O-2172" title="O-2172">O-2172</a></li> <li><a href="/wiki/Oroxylin_A" title="Oroxylin A">Oroxylin A</a></li> <li><a href="/wiki/Perafensine" title="Perafensine">Perafensine</a></li> <li><a href="/wiki/Pridefine" title="Pridefine">Pridefine</a></li> <li><a href="/wiki/Radafaxine" title="Radafaxine">Radafaxine</a></li> <li><a href="/wiki/Rimcazole" title="Rimcazole">Rimcazole</a></li> <li><a href="/wiki/Sertraline" title="Sertraline">Sertraline</a></li> <li><a href="/wiki/Sibutramine" title="Sibutramine">Sibutramine</a></li> <li><a href="/wiki/Solriamfetol" title="Solriamfetol">Solriamfetol</a></li> <li><a href="/wiki/Tametraline" title="Tametraline">Tametraline</a></li> <li><a href="/wiki/Tedatioxetine" title="Tedatioxetine">Tedatioxetine</a></li> <li><a href="/wiki/Threohydrobupropion" title="Threohydrobupropion">Threohydrobupropion</a></li> <li><a href="/wiki/Tripelennamine" title="Tripelennamine">Tripelennamine</a></li> <li><a href="/wiki/Venlafaxine" title="Venlafaxine">Venlafaxine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter"><abbr title="Norepinephrine transporter">NET</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Norepinephrine transporter</span><br /><small>(<a href="/wiki/Norepinephrine_reuptake_inhibitors" class="mw-redirect" title="Norepinephrine reuptake inhibitors"><abbr title="Norepinephrine reuptake inhibitors">NRIs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Norepinephrine reuptake inhibitors</span>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Selective norepinephrine reuptake inhibitors:</i> <a href="/wiki/Amedalin" title="Amedalin">Amedalin</a></li> <li><a href="/wiki/Alseroxylon" title="Alseroxylon">Alseroxylon</a></li> <li><a href="/wiki/Ciclazindol" title="Ciclazindol">Ciclazindol</a></li> <li><a href="/wiki/Daledalin" title="Daledalin">Daledalin</a></li> <li><a href="/wiki/Edivoxetine" title="Edivoxetine">Edivoxetine</a></li> <li><a href="/wiki/Esreboxetine" title="Esreboxetine">Esreboxetine</a></li> <li><a href="/wiki/Lortalamine" title="Lortalamine">Lortalamine</a></li> <li><a href="/wiki/Mazindol" title="Mazindol">Mazindol</a></li> <li><a href="/wiki/Nisoxetine" title="Nisoxetine">Nisoxetine</a></li> <li><a href="/wiki/Reboxetine" title="Reboxetine">Reboxetine</a></li> <li><a href="/wiki/Talopram" title="Talopram">Talopram</a></li> <li><a href="/wiki/Talsupram" title="Talsupram">Talsupram</a></li> <li><a href="/wiki/Tandamine" title="Tandamine">Tandamine</a></li> <li><a href="/wiki/Teniloxazine" title="Teniloxazine">Teniloxazine</a></li> <li><a href="/wiki/Viloxazine" title="Viloxazine">Viloxazine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Norepinephrine–dopamine reuptake inhibitors:</i> <a href="/wiki/Amineptine" title="Amineptine">Amineptine</a></li> <li><a href="/wiki/Bupropion" title="Bupropion">Bupropion</a></li> <li><a href="/wiki/Fencamine" title="Fencamine">Fencamine</a></li> <li><a href="/wiki/Fencamfamin" title="Fencamfamin">Fencamfamin</a></li> <li><a href="/wiki/Hydroxybupropion" title="Hydroxybupropion">Hydroxybupropion</a></li> <li><a href="/wiki/Lefetamine" title="Lefetamine">Lefetamine</a></li> <li><a href="/wiki/Levophacetoperane" title="Levophacetoperane">Levophacetoperane</a></li> <li><a href="/wiki/LR-5182" title="LR-5182">LR-5182</a></li> <li><a href="/wiki/Manifaxine" title="Manifaxine">Manifaxine</a></li> <li><a href="/wiki/Methylphenidate" title="Methylphenidate">Methylphenidate</a></li> <li><a href="/wiki/Nomifensine" title="Nomifensine">Nomifensine</a></li> <li><a href="/wiki/O-2172" title="O-2172">O-2172</a></li> <li><a href="/wiki/Radafaxine" title="Radafaxine">Radafaxine</a></li> <li><a href="/wiki/Serdexmethylphenidate" title="Serdexmethylphenidate">Serdexmethylphenidate</a></li> <li><a href="/wiki/Solriamfetol" title="Solriamfetol">Solriamfetol</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Serotonin–norepinephrine reuptake inhibitors:</i> <a href="/wiki/Atomoxetine" title="Atomoxetine">Atomoxetine (tomoxetine)</a></li> <li><a href="/wiki/CP-39,332" title="CP-39,332">CP-39,332</a></li> <li><a href="/wiki/Desvenlafaxine" title="Desvenlafaxine">Desvenlafaxine</a></li> <li><a href="/wiki/Duloxetine" title="Duloxetine">Duloxetine</a></li> <li><a href="/wiki/Eclanamine" title="Eclanamine">Eclanamine</a></li> <li><a href="/wiki/Levomilnacipran" title="Levomilnacipran">Levomilnacipran</a></li> <li><a href="/wiki/McN5652" title="McN5652">McN5652</a></li> <li><a href="/wiki/Milnacipran" title="Milnacipran">Milnacipran</a></li> <li><a href="/wiki/N-Methyl-PPPA" title="N-Methyl-PPPA">N-Methyl-PPPA</a></li> <li><a href="/w/index.php?title=Nafenodone&action=edit&redlink=1" class="new" title="Nafenodone (page does not exist)">Nafenodone</a></li> <li><a href="/wiki/PPPA_(drug)" title="PPPA (drug)">PPPA</a></li> <li><a href="/wiki/Tofenacin" title="Tofenacin">Tofenacin</a></li> <li><a href="/wiki/Venlafaxine" title="Venlafaxine">Venlafaxine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Serotonin–norepinephrine–dopamine reuptake inhibitors:</i> <a href="/wiki/3,3-Diphenylcyclobutanamine" title="3,3-Diphenylcyclobutanamine">3,3-Diphenylcyclobutanamine</a></li> <li><a href="/wiki/Amifitadine" class="mw-redirect" title="Amifitadine">Amifitadine</a></li> <li><a href="/wiki/Ansofaxine" title="Ansofaxine">Ansofaxine</a></li> <li><a href="/wiki/Bicifadine" title="Bicifadine">Bicifadine</a></li> <li><a href="/wiki/Brasofensine" title="Brasofensine">Brasofensine</a></li> <li><a href="/wiki/Centanafadine" title="Centanafadine">Centanafadine</a></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a></li> <li><a href="/wiki/Dasotraline" title="Dasotraline">Dasotraline</a></li> <li><a href="/wiki/Desmethylsertraline" title="Desmethylsertraline">Desmethylsertraline</a></li> <li><a href="/wiki/Desmethylsibutramine" title="Desmethylsibutramine">Desmethylsibutramine (BTS-54354)</a></li> <li><a href="/wiki/Diclofensine" title="Diclofensine">Diclofensine</a></li> <li><a href="/wiki/Didesmethylsibutramine" title="Didesmethylsibutramine">Didesmethylsibutramine (BTS-54505)</a></li> <li><a href="/wiki/DOV-102677" class="mw-redirect" title="DOV-102677">DOV-102677</a></li> <li><a href="/wiki/DOV-216303" class="mw-redirect" title="DOV-216303">DOV-216303</a></li> <li><a href="/wiki/EXP-561" title="EXP-561">EXP-561</a></li> <li><a href="/wiki/Fezolamine" title="Fezolamine">Fezolamine</a></li> <li><a href="/wiki/HDMP-28" title="HDMP-28">HDMP-28</a></li> <li><a href="/wiki/HP-505" title="HP-505">HP-505</a></li> <li><a href="/wiki/Indatraline" title="Indatraline">Indatraline</a></li> <li><a href="/wiki/JNJ-7925476" title="JNJ-7925476">JNJ-7925476</a></li> <li><a href="/wiki/JZ-IV-10" title="JZ-IV-10">JZ-IV-10</a></li> <li><a href="/wiki/Liafensine" title="Liafensine">Liafensine</a></li> <li><a href="/wiki/Mazindol" title="Mazindol">Mazindol</a></li> <li><a href="/wiki/Naphyrone" title="Naphyrone">Naphyrone</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Nefopam" title="Nefopam">Nefopam</a></li> <li><a href="/wiki/NS-2359" title="NS-2359">NS-2359</a></li> <li><a href="/wiki/Perafensine" title="Perafensine">Perafensine</a></li> <li><a href="/wiki/PRC200" class="mw-redirect" title="PRC200">PRC200</a></li> <li><a href="/wiki/Pridefine" title="Pridefine">Pridefine</a></li> <li><a href="/w/index.php?title=SEP-228431&action=edit&redlink=1" class="new" title="SEP-228431 (page does not exist)">SEP-228431</a></li> <li><a href="/w/index.php?title=SEP-228432&action=edit&redlink=1" class="new" title="SEP-228432 (page does not exist)">SEP-228432</a></li> <li><a href="/wiki/Sibutramine" title="Sibutramine">Sibutramine</a></li> <li><a href="/wiki/Tedatioxetine" title="Tedatioxetine">Tedatioxetine</a></li> <li><a href="/wiki/Tesofensine" title="Tesofensine">Tesofensine</a></li> <li><a href="/wiki/Threohydrobupropion" title="Threohydrobupropion">Threohydrobupropion</a></li> <li><a href="/wiki/Tropane" title="Tropane">Tropanes</a> (e.g., <a href="/wiki/Cocaine" title="Cocaine">cocaine</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Tricyclic antidepressants:</i> <a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Butriptyline" title="Butriptyline">Butriptyline</a></li> <li><a href="/wiki/Cianopramine" title="Cianopramine">Cianopramine</a></li> <li><a href="/wiki/Clomipramine" title="Clomipramine">Clomipramine</a></li> <li><a href="/wiki/Desipramine" title="Desipramine">Desipramine</a></li> <li><a href="/wiki/Dosulepin" title="Dosulepin">Dosulepin (dothiepin)</a></li> <li><a href="/wiki/Doxepin" title="Doxepin">Doxepin</a></li> <li><a href="/wiki/Imipramine" title="Imipramine">Imipramine</a></li> <li><a href="/wiki/Lofepramine" title="Lofepramine">Lofepramine</a></li> <li><a href="/wiki/Melitracen" title="Melitracen">Melitracen</a></li> <li><a href="/wiki/Nortriptyline" title="Nortriptyline">Nortriptyline</a></li> <li><a href="/wiki/Protriptyline" title="Protriptyline">Protriptyline</a></li> <li><a href="/wiki/Trimipramine" title="Trimipramine">Trimipramine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Tetracyclic antidepressants:</i> <a href="/wiki/Amoxapine" title="Amoxapine">Amoxapine</a></li> <li><a href="/wiki/Maprotiline" title="Maprotiline">Maprotiline</a></li> <li><a href="/wiki/Mianserin" title="Mianserin">Mianserin</a></li> <li><a href="/wiki/Oxaprotiline" title="Oxaprotiline">Oxaprotiline</a></li> <li><a href="/wiki/Setiptiline" title="Setiptiline">Setiptiline</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Others:</i> <a href="/wiki/Histamine_antagonist" class="mw-redirect" title="Histamine antagonist">Antihistamines</a> (e.g., <a href="/wiki/Brompheniramine" title="Brompheniramine">brompheniramine</a>, <a href="/wiki/Chlorphenamine" title="Chlorphenamine">chlorphenamine</a>, <a href="/wiki/Pheniramine" title="Pheniramine">pheniramine</a>, <a href="/wiki/Tripelennamine" title="Tripelennamine">tripelennamine</a>)</li> <li><a href="/wiki/Antipsychotic" title="Antipsychotic">Antipsychotics</a> (e.g., <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>)</li> <li><a href="/wiki/Arylcyclohexylamine" title="Arylcyclohexylamine">Arylcyclohexylamines</a> (e.g., <a href="/wiki/Ketamine" title="Ketamine">ketamine</a>, <a href="/wiki/Phencyclidine" title="Phencyclidine">phencyclidine</a>)</li> <li><a href="/wiki/Dopexamine" title="Dopexamine">Dopexamine</a></li> <li><a href="/wiki/Ephenidine" title="Ephenidine">Ephenidine</a></li> <li><i><a href="/wiki/Ginkgo_biloba" title="Ginkgo biloba">Ginkgo biloba</a></i></li> <li><a href="/wiki/Indeloxazine" title="Indeloxazine">Indeloxazine</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Opioid" title="Opioid">Opioids</a> (e.g., <a href="/wiki/Desmetramadol" title="Desmetramadol">desmetramadol</a>, <a href="/wiki/Methadone" title="Methadone">methadone</a>, <a href="/wiki/Pethidine" title="Pethidine">pethidine (meperidine)</a>, <a href="/wiki/Tapentadol" title="Tapentadol">tapentadol</a>, <a href="/wiki/Tramadol" title="Tramadol">tramadol</a>, <a href="/wiki/Levorphanol" title="Levorphanol">levorphanol</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Serotonin_transporter" title="Serotonin transporter"><abbr title="Serotonin transporter">SERT</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Serotonin transporter</span><br /><small>(<a href="/wiki/Serotonin_reuptake_inhibitors" class="mw-redirect" title="Serotonin reuptake inhibitors"><abbr title="Serotonin reuptake inhibitors">SRIs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Serotonin reuptake inhibitors</span>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Selective serotonin reuptake inhibitors:</i> <a href="/wiki/6-Nitroquipazine" title="6-Nitroquipazine">6-Nitroquipazine</a></li> <li><a href="/wiki/Alaproclate" title="Alaproclate">Alaproclate</a></li> <li><a href="/wiki/Centpropazine" title="Centpropazine">Centpropazine</a></li> <li><a href="/wiki/Cericlamine" title="Cericlamine">Cericlamine</a></li> <li><a href="/wiki/Citalopram" title="Citalopram">Citalopram</a></li> <li><a href="/wiki/Dapoxetine" title="Dapoxetine">Dapoxetine</a></li> <li><a href="/wiki/Desmethylcitalopram" title="Desmethylcitalopram">Desmethylcitalopram</a></li> <li><a href="/wiki/Didesmethylcitalopram" title="Didesmethylcitalopram">Didesmethylcitalopram</a></li> <li><a href="/wiki/Escitalopram" title="Escitalopram">Escitalopram</a></li> <li><a href="/wiki/Femoxetine" title="Femoxetine">Femoxetine</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Fluvoxamine" title="Fluvoxamine">Fluvoxamine</a></li> <li><a href="/wiki/Indalpine" title="Indalpine">Indalpine</a></li> <li><a href="/wiki/Ifoxetine" title="Ifoxetine">Ifoxetine</a></li> <li><a href="/wiki/Norfluoxetine" class="mw-redirect" title="Norfluoxetine">Norfluoxetine</a></li> <li><a href="/wiki/Omiloxetine" title="Omiloxetine">Omiloxetine</a></li> <li><a href="/wiki/Panuramine" title="Panuramine">Panuramine</a></li> <li><a href="/wiki/Paroxetine" title="Paroxetine">Paroxetine</a></li> <li><a href="/wiki/PIM-35" title="PIM-35">PIM-35</a></li> <li><a href="/wiki/Pirandamine" title="Pirandamine">Pirandamine</a></li> <li><a href="/wiki/RTI-353" title="RTI-353">RTI-353</a></li> <li><a href="/wiki/Seproxetine" title="Seproxetine">Seproxetine</a></li> <li><a href="/wiki/Sertraline" title="Sertraline">Sertraline</a></li> <li><a href="/wiki/Zimelidine" title="Zimelidine">Zimelidine</a></li></ul> <ul><li><i>Selective serotonin reuptake inhibitors and serotonin receptor modulators:</i> <a href="/wiki/Etoperidone" title="Etoperidone">Etoperidone</a></li> <li><a href="/wiki/Litoxetine" title="Litoxetine">Litoxetine</a></li> <li><a href="/wiki/Lubazodone" title="Lubazodone">Lubazodone</a></li> <li><a href="/wiki/LY-393558" title="LY-393558">LY-393558</a></li> <li><a href="/wiki/Quipazine" title="Quipazine">Quipazine</a></li> <li><a href="/wiki/SB-649915" class="mw-redirect" title="SB-649915">SB-649915</a></li> <li><a href="/wiki/TGBA01AD" title="TGBA01AD">TGBA01AD</a></li> <li><a href="/wiki/Trazodone" title="Trazodone">Trazodone</a></li> <li><a href="/wiki/Vilazodone" title="Vilazodone">Vilazodone</a></li> <li><a href="/wiki/Vortioxetine" title="Vortioxetine">Vortioxetine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Serotonin–norepinephrine reuptake inhibitors:</i> <a href="/wiki/Atomoxetine" title="Atomoxetine">Atomoxetine (tomoxetine)</a></li> <li><a href="/wiki/Bicifadine" title="Bicifadine">Bicifadine</a></li> <li><a href="/w/index.php?title=CP-39332&action=edit&redlink=1" class="new" title="CP-39332 (page does not exist)">CP-39332</a></li> <li><a href="/wiki/Desvenlafaxine" title="Desvenlafaxine">Desvenlafaxine</a></li> <li><a href="/wiki/Duloxetine" title="Duloxetine">Duloxetine</a></li> <li><a href="/wiki/Eclanamine" title="Eclanamine">Eclanamine</a></li> <li><a href="/wiki/Levomilnacipran" title="Levomilnacipran">Levomilnacipran</a></li> <li><a href="/wiki/McN5652" title="McN5652">McN5652</a></li> <li><a href="/wiki/Milnacipran" title="Milnacipran">Milnacipran</a></li> <li><a href="/wiki/N-Methyl-PPPA" title="N-Methyl-PPPA">N-Methyl-PPPA</a></li> <li><a href="/wiki/PPPA_(drug)" title="PPPA (drug)">PPPA</a></li> <li><a href="/wiki/Tofenacin" title="Tofenacin">Tofenacin</a></li> <li><a href="/wiki/Venlafaxine" title="Venlafaxine">Venlafaxine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Serotonin–norepinephrine–dopamine reuptake inhibitors:</i> <a href="/wiki/3,3-Diphenylcyclobutanamine" title="3,3-Diphenylcyclobutanamine">3,3-Diphenylcyclobutanamine</a></li> <li><a href="/wiki/Amifitadine" class="mw-redirect" title="Amifitadine">Amifitadine</a></li> <li><a href="/wiki/Ansofaxine" title="Ansofaxine">Ansofaxine</a></li> <li><a href="/wiki/Bicifadine" title="Bicifadine">Bicifadine</a></li> <li><a href="/wiki/Brasofensine" title="Brasofensine">Brasofensine</a></li> <li><a href="/wiki/Centanafadine" title="Centanafadine">Centanafadine</a></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a></li> <li><a href="/wiki/Dasotraline" title="Dasotraline">Dasotraline</a></li> <li><a href="/wiki/Desmethylsertraline" title="Desmethylsertraline">Desmethylsertraline</a></li> <li><a href="/wiki/Desmethylsibutramine" title="Desmethylsibutramine">Desmethylsibutramine (BTS-54354)</a></li> <li><a href="/wiki/Diclofensine" title="Diclofensine">Diclofensine</a></li> <li><a href="/wiki/Didesmethylsibutramine" title="Didesmethylsibutramine">Didesmethylsibutramine (BTS-54505)</a></li> <li><a href="/wiki/DOV-102677" class="mw-redirect" title="DOV-102677">DOV-102677</a></li> <li><a href="/wiki/DOV-216303" class="mw-redirect" title="DOV-216303">DOV-216303</a></li> <li><a href="/wiki/EXP-561" title="EXP-561">EXP-561</a></li> <li><a href="/wiki/Fezolamine" title="Fezolamine">Fezolamine</a></li> <li><a href="/wiki/HDMP-28" title="HDMP-28">HDMP-28</a></li> <li><a href="/wiki/HP-505" title="HP-505">HP-505</a></li> <li><a href="/wiki/Indatraline" title="Indatraline">Indatraline</a></li> <li><a href="/wiki/JNJ-7925476" title="JNJ-7925476">JNJ-7925476</a></li> <li><a href="/wiki/JZ-IV-10" title="JZ-IV-10">JZ-IV-10</a></li> <li><a href="/wiki/Liafensine" title="Liafensine">Liafensine</a></li> <li><a href="/wiki/Mazindol" title="Mazindol">Mazindol</a></li> <li><a href="/wiki/Naphyrone" title="Naphyrone">Naphyrone</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Nefopam" title="Nefopam">Nefopam</a></li> <li><a href="/wiki/NS-2359" title="NS-2359">NS-2359</a></li> <li><a href="/wiki/Perafensine" title="Perafensine">Perafensine</a></li> <li><a href="/wiki/PRC200" class="mw-redirect" title="PRC200">PRC200</a></li> <li><a href="/wiki/Pridefine" title="Pridefine">Pridefine</a></li> <li><a href="/w/index.php?title=SEP-228431&action=edit&redlink=1" class="new" title="SEP-228431 (page does not exist)">SEP-228431</a></li> <li><a href="/w/index.php?title=SEP-228432&action=edit&redlink=1" class="new" title="SEP-228432 (page does not exist)">SEP-228432</a></li> <li><a href="/wiki/Sibutramine" title="Sibutramine">Sibutramine</a></li> <li><a href="/wiki/Tedatioxetine" title="Tedatioxetine">Tedatioxetine</a></li> <li><a href="/wiki/Tesofensine" title="Tesofensine">Tesofensine</a></li> <li><a href="/wiki/Threohydrobupropion" title="Threohydrobupropion">Threohydrobupropion</a></li> <li><a href="/wiki/Tropane" title="Tropane">Tropanes</a> (e.g., <a href="/wiki/Cocaine" title="Cocaine">cocaine</a>)</li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Tricyclic antidepressants:</i> <a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Cianopramine" title="Cianopramine">Cianopramine</a></li> <li><a href="/wiki/Clomipramine" title="Clomipramine">Clomipramine</a></li> <li><a href="/wiki/Cyanodothiepin" title="Cyanodothiepin">Cyanodothiepin</a></li> <li><a href="/wiki/Desipramine" title="Desipramine">Desipramine</a></li> <li><a href="/wiki/Dosulepin" title="Dosulepin">Dosulepin (dothiepin)</a></li> <li><a href="/wiki/Doxepin" title="Doxepin">Doxepin</a></li> <li><a href="/wiki/Imipramine" title="Imipramine">Imipramine</a></li> <li><a href="/wiki/Lofepramine" title="Lofepramine">Lofepramine</a></li> <li><a href="/wiki/Nortriptyline" title="Nortriptyline">Nortriptyline</a></li> <li><a href="/wiki/Pipofezine" title="Pipofezine">Pipofezine</a></li> <li><a href="/wiki/Protriptyline" title="Protriptyline">Protriptyline</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Others:</i> <a href="/w/index.php?title=A-80426&action=edit&redlink=1" class="new" title="A-80426 (page does not exist)">A-80426</a></li> <li><a href="/wiki/Amoxapine" title="Amoxapine">Amoxapine</a></li> <li><a href="/wiki/Antihistamine" title="Antihistamine">Antihistamines</a> (e.g., <a href="/wiki/Brompheniramine" title="Brompheniramine">brompheniramine</a>, <a href="/wiki/Chlorphenamine" title="Chlorphenamine">chlorphenamine</a>, <a href="/wiki/Dimenhydrinate" title="Dimenhydrinate">dimenhydrinate</a>, <a href="/wiki/Diphenhydramine" title="Diphenhydramine">diphenhydramine</a>, <a href="/wiki/Mepyramine" title="Mepyramine">mepyramine (pyrilamine)</a>, <a href="/wiki/Pheniramine" title="Pheniramine">pheniramine</a>, <a href="/wiki/Tripelennamine" title="Tripelennamine">tripelennamine</a>)</li> <li><a href="/wiki/Antipsychotic" title="Antipsychotic">Antipsychotics</a> (e.g., <a href="/wiki/Loxapine" title="Loxapine">loxapine</a>, <a href="/wiki/Ziprasidone" title="Ziprasidone">ziprasidone</a>)</li> <li><a href="/wiki/Arylcyclohexylamine" title="Arylcyclohexylamine">Arylcyclohexylamines</a> (e.g., <a href="/wiki/3-MeO-PCP" title="3-MeO-PCP">3-MeO-PCP</a>, <a href="/wiki/Esketamine" title="Esketamine">esketamine</a>, <a href="/wiki/Ketamine" title="Ketamine">ketamine</a>, <a href="/wiki/Methoxetamine" title="Methoxetamine">methoxetamine</a>, <a href="/wiki/Phencyclidine" title="Phencyclidine">phencyclidine</a>)</li> <li><a href="/wiki/Cyclobenzaprine" title="Cyclobenzaprine">Cyclobenzaprine</a></li> <li><a href="/wiki/Delucemine" title="Delucemine">Delucemine</a></li> <li><a href="/wiki/Dextromethorphan" title="Dextromethorphan">Dextromethorphan</a></li> <li><a href="/wiki/Dextrorphan" title="Dextrorphan">Dextrorphan</a></li> <li><a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/Hypidone" title="Hypidone">Hypidone</a></li> <li><a href="/wiki/Medifoxamine" title="Medifoxamine">Medifoxamine</a></li> <li><a href="/wiki/Mesembrine" title="Mesembrine">Mesembrine</a></li> <li><a href="/wiki/Mifepristone" title="Mifepristone">Mifepristone</a></li> <li><a href="/wiki/MIN-117" title="MIN-117">MIN-117 (WF-516)</a></li> <li><a href="/wiki/N-Methylserotonin" title="N-Methylserotonin">N-Me-5-HT</a></li> <li><a href="/wiki/Opioid" title="Opioid">Opioids</a> (e.g., <a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">dextropropoxyphene</a>, <a href="/wiki/Methadone" title="Methadone">methadone</a>, <a href="/wiki/Pethidine" title="Pethidine">pethidine (meperidine)</a>, <a href="/wiki/Levorphanol" title="Levorphanol">levorphanol</a>, <a href="/wiki/Tapentadol" title="Tapentadol">tapentadol</a>, <a href="/wiki/Tramadol" title="Tramadol">tramadol</a>)</li> <li><a href="/wiki/Roxindole" title="Roxindole">Roxindole</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Vesicular_monoamine_transporters" class="mw-redirect" title="Vesicular monoamine transporters"><abbr title="Vesicular monoamine transporters">VMATs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Vesicular monoamine transporters</span></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/Substituted_amphetamine" title="Substituted amphetamine">Amphetamines</a> (e.g., <a href="/wiki/Amphetamine" title="Amphetamine">amphetamine</a>, <a href="/wiki/Methamphetamine" title="Methamphetamine">methamphetamine</a>, <a href="/wiki/MDMA" title="MDMA">MDMA</a>)</li> <li><a href="/w/index.php?title=3-Amino-2-phenylpropene&action=edit&redlink=1" class="new" title="3-Amino-2-phenylpropene (page does not exist)">APP</a></li> <li><a href="/w/index.php?title=7-Azido-8-iodoketanserin&action=edit&redlink=1" class="new" title="7-Azido-8-iodoketanserin (page does not exist)">AZIK</a></li> <li><a href="/wiki/Bietaserpine" title="Bietaserpine">Bietaserpine</a></li> <li><a href="/wiki/Deserpidine" title="Deserpidine">Deserpidine</a></li> <li><a href="/wiki/Deutetrabenazine" title="Deutetrabenazine">Deutetrabenazine</a></li> <li><a href="/wiki/Dihydrotetrabenazine" title="Dihydrotetrabenazine">Dihydrotetrabenazine</a></li> <li><a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/GBR-12935" title="GBR-12935">GBR-12935</a></li> <li><a href="/w/index.php?title=GZ-793A&action=edit&redlink=1" class="new" title="GZ-793A (page does not exist)">GZ-793A</a></li> <li><a href="/wiki/Ibogaine" title="Ibogaine">Ibogaine</a></li> <li><a href="/wiki/Ketanserin" title="Ketanserin">Ketanserin</a></li> <li><a href="/wiki/Lobeline" title="Lobeline">Lobeline</a></li> <li><a href="/w/index.php?title=Methoxytetrabenazine&action=edit&redlink=1" class="new" title="Methoxytetrabenazine (page does not exist)">Methoxytetrabenazine</a></li> <li><a href="/wiki/Reserpine" title="Reserpine">Reserpine</a></li> <li><a href="/wiki/Rose_bengal" title="Rose bengal">Rose bengal</a></li> <li><a href="/wiki/Tetrabenazine" title="Tetrabenazine">Tetrabenazine</a></li> <li><a href="/wiki/Valbenazine" title="Valbenazine">Valbenazine</a></li> <li><a href="/wiki/Vanoxerine" title="Vanoxerine">Vanoxerine (GBR-12909)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>DAT enhancers:</i> <a href="/wiki/Luteolin" title="Luteolin">Luteolin</a></li></ul> <ul><li><i>DAT modulators:</i> <i>Agonist-like:</i> <a href="/wiki/SoRI-9804" title="SoRI-9804">SoRI-9804</a></li> <li><a href="/w/index.php?title=SoRI-20040&action=edit&redlink=1" class="new" title="SoRI-20040 (page does not exist)">SoRI-20040</a>; <i>Antagonist-like:</i> <a href="/wiki/SoRI-20041" title="SoRI-20041">SoRI-20041</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><small><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a> • <a href="/wiki/Template:Monoamine_releasing_agents" title="Template:Monoamine releasing agents">Monoamine releasing agents</a> • <a href="/wiki/Template:Adrenergics" class="mw-redirect" title="Template:Adrenergics">Adrenergics</a> • <a href="/wiki/Template:Dopaminergics" class="mw-redirect" title="Template:Dopaminergics">Dopaminergics</a> • <a href="/wiki/Template:Serotonergics" class="mw-redirect" title="Template:Serotonergics">Serotonergics</a> • <a href="/wiki/Template:Monoamine_metabolism_modulators" title="Template:Monoamine metabolism modulators">Monoamine metabolism modulators</a> • <a href="/wiki/Template:Monoamine_neurotoxins" title="Template:Monoamine neurotoxins">Monoamine neurotoxins</a></i></small></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Monoamine_releasing_agents" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Monoamine_releasing_agents" title="Template:Monoamine releasing agents"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Monoamine_releasing_agents" title="Template talk:Monoamine releasing agents"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Monoamine_releasing_agents" title="Special:EditPage/Template:Monoamine releasing agents"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Monoamine_releasing_agents" style="font-size:114%;margin:0 4em"><a href="/wiki/Monoamine_releasing_agent" title="Monoamine releasing agent">Monoamine releasing agents</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Dopamine_releasing_agents" class="mw-redirect" title="Dopamine releasing agents"><abbr title="Dopamine releasing agents">DRAs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Dopamine releasing agents</span></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Morpholines:</i> <a href="/wiki/Fenbutrazate" title="Fenbutrazate">Fenbutrazate</a></li> <li><a href="/wiki/Fenmetramide" title="Fenmetramide">Fenmetramide</a></li> <li><a href="/wiki/Morazone" title="Morazone">Morazone</a></li> <li><a href="/wiki/Morforex" title="Morforex">Morforex</a></li> <li><a href="/wiki/Phendimetrazine" title="Phendimetrazine">Phendimetrazine</a></li> <li><a href="/wiki/Phenmetrazine" title="Phenmetrazine">Phenmetrazine</a></li> <li><a href="/wiki/Pseudophenmetrazine" title="Pseudophenmetrazine">Pseudophenmetrazine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Oxazolines:</i> <a href="/wiki/4-Methylaminorex" title="4-Methylaminorex">4-MAR</a></li> <li><a href="/wiki/Aminorex" title="Aminorex">Aminorex</a></li> <li><a href="/wiki/Clominorex" title="Clominorex">Clominorex</a></li> <li><a href="/wiki/Cyclazodone" title="Cyclazodone">Cyclazodone</a></li> <li><a href="/wiki/Fenozolone" title="Fenozolone">Fenozolone</a></li> <li><a href="/wiki/Fluminorex" title="Fluminorex">Fluminorex</a></li> <li><a href="/wiki/Pemoline" title="Pemoline">Pemoline</a></li> <li><a href="/wiki/Thozalinone" title="Thozalinone">Thozalinone</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Phenethylamines:</i> <a href="/wiki/Phenylethanolamine" title="Phenylethanolamine">2-OH-PEA</a></li> <li><a href="/wiki/4-Chlorophenylisobutylamine" title="4-Chlorophenylisobutylamine">4-CAB</a></li> <li><a href="/wiki/4-Fluoroamphetamine" title="4-Fluoroamphetamine">4-FA</a></li> <li><a href="/wiki/4-Fluoromethamphetamine" title="4-Fluoromethamphetamine">4-FMA</a></li> <li><a href="/wiki/4-Methylamphetamine" title="4-Methylamphetamine">4-MA</a></li> <li><a href="/wiki/4-Methylmethamphetamine" class="mw-redirect" title="4-Methylmethamphetamine">4-MMA</a></li> <li><a href="/wiki/Alfetamine" title="Alfetamine">Alfetamine</a></li> <li><a href="/wiki/Amfecloral" title="Amfecloral">Amfecloral</a></li> <li><a href="/wiki/Amfepentorex" title="Amfepentorex">Amfepentorex</a></li> <li><a href="/wiki/Amfepramone" title="Amfepramone">Amfepramone</a></li> <li><a href="/wiki/Amphetamine" title="Amphetamine">Amphetamine</a> (<a href="/wiki/Dextroamphetamine" title="Dextroamphetamine">Dextroamphetamine</a></li> <li><a href="/wiki/Levoamphetamine" title="Levoamphetamine">Levoamphetamine</a>)</li> <li><a href="/wiki/Amphetaminil" class="mw-redirect" title="Amphetaminil">Amphetaminil</a></li> <li><a href="/wiki/%CE%92-Methylphenethylamine" title="Β-Methylphenethylamine">β-Me-PEA</a></li> <li><a href="/wiki/1,3-Benzodioxolylbutanamine" title="1,3-Benzodioxolylbutanamine">BDB</a></li> <li><a href="/wiki/BOH_(drug)" title="BOH (drug)">BOH</a></li> <li><a href="/wiki/Benzphetamine" title="Benzphetamine">Benzphetamine</a></li> <li><a href="/wiki/Buphedrone" title="Buphedrone">Buphedrone</a></li> <li><a href="/wiki/Butylone" title="Butylone">Butylone</a></li> <li><a href="/wiki/Cathine" title="Cathine">Cathine</a></li> <li><a href="/wiki/Cathinone" title="Cathinone">Cathinone</a></li> <li><a href="/wiki/Clobenzorex" title="Clobenzorex">Clobenzorex</a></li> <li><a href="/wiki/Clortermine" title="Clortermine">Clortermine</a></li> <li><a href="/wiki/D-Deprenyl" title="D-Deprenyl">D-Deprenyl</a></li> <li><a href="/wiki/Dimethoxyamphetamine" title="Dimethoxyamphetamine">DMA</a></li> <li><a href="/wiki/Dimethoxymethamphetamine" title="Dimethoxymethamphetamine">DMMA</a></li> <li><a href="/wiki/Dimethylamphetamine" title="Dimethylamphetamine">Dimethylamphetamine</a></li> <li><a href="/wiki/Ephedrine" title="Ephedrine">Ephedrine</a></li> <li><a href="/wiki/Ethcathinone" title="Ethcathinone">Ethcathinone</a></li> <li><a href="/wiki/1,3-Benzodioxolyl-N-ethylbutanamine" title="1,3-Benzodioxolyl-N-ethylbutanamine">EBDB</a></li> <li><a href="/wiki/Ethylone" title="Ethylone">Ethylone</a></li> <li><a href="/wiki/Etilamfetamine" title="Etilamfetamine">Etilamfetamine</a></li> <li><a href="/wiki/Famprofazone" title="Famprofazone">Famprofazone</a></li> <li><a href="/wiki/Fenethylline" title="Fenethylline">Fenethylline</a></li> <li><a href="/wiki/Fenproporex" title="Fenproporex">Fenproporex</a></li> <li><a href="/wiki/Flephedrone" title="Flephedrone">Flephedrone</a></li> <li><a href="/wiki/Fludorex" title="Fludorex">Fludorex</a></li> <li><a href="/wiki/Furfenorex" title="Furfenorex">Furfenorex</a></li> <li><a href="/wiki/Hordenine" title="Hordenine">Hordenine</a></li> <li><a href="/wiki/4-Hydroxyamphetamine" title="4-Hydroxyamphetamine">4-Hydroxyamphetamine</a></li> <li><a href="/wiki/Iofetamine_(123I)" title="Iofetamine (123I)">Iofetamine (123I)</a></li> <li><a href="/wiki/Lisdexamfetamine" title="Lisdexamfetamine">Lisdexamfetamine</a></li> <li><a href="/wiki/Lophophine" title="Lophophine">Lophophine</a></li> <li><a href="/wiki/Mefenorex" title="Mefenorex">Mefenorex</a></li> <li><a href="/wiki/Mephedrone" title="Mephedrone">Mephedrone</a></li> <li><a href="/wiki/Metamfepramone" title="Metamfepramone">Metamfepramone</a></li> <li><a href="/wiki/Methamphetamine" title="Methamphetamine">Methamphetamine</a> <ul><li><a href="/wiki/Dextromethamphetamine" class="mw-redirect" title="Dextromethamphetamine">Dextromethamphetamine</a></li> <li><a href="/wiki/Levomethamphetamine" class="mw-redirect" title="Levomethamphetamine">Levomethamphetamine</a></li></ul></li> <li><a href="/wiki/Methcathinone" title="Methcathinone">Methcathinone</a></li> <li><a href="/wiki/Methedrone" title="Methedrone">Methedrone</a></li> <li><a href="/wiki/MMDA_(drug)" title="MMDA (drug)">MMDA</a></li> <li><a href="/wiki/MMDMA" title="MMDMA">MMDMA</a></li> <li><a href="/wiki/1,3-Benzodioxolyl-N-methylbutanamine" class="mw-redirect" title="1,3-Benzodioxolyl-N-methylbutanamine">MBDB</a></li> <li><a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a></li> <li><a href="/wiki/Methylenedioxyethylamphetamine" class="mw-redirect" title="Methylenedioxyethylamphetamine">MDEA</a></li> <li><a href="/wiki/MDMA" title="MDMA">MDMA (midomafetamine)</a></li> <li><a href="/wiki/Methylenedioxymethylphenethylamine" class="mw-redirect" title="Methylenedioxymethylphenethylamine">MDMPEA</a></li> <li><a href="/wiki/Methylenedioxyhydroxyamphetamine" class="mw-redirect" title="Methylenedioxyhydroxyamphetamine">MDOH</a></li> <li><a href="/wiki/Methylenedioxyphenethylamine" class="mw-redirect" title="Methylenedioxyphenethylamine">MDPEA</a></li> <li><a href="/wiki/Methylone" title="Methylone">Methylone</a></li> <li><a href="/wiki/Morforex" title="Morforex">Morforex</a></li> <li><a href="/wiki/Ortetamine" title="Ortetamine">Ortetamine</a></li> <li><a href="/wiki/Para-Bromoamphetamine" title="Para-Bromoamphetamine"><i>p</i>BA</a></li> <li><a href="/wiki/Para-Chloroamphetamine" title="Para-Chloroamphetamine"><i>p</i>CA</a></li> <li><a href="/wiki/Para-Iodoamphetamine" title="Para-Iodoamphetamine"><i>p</i>IA</a></li> <li><a href="/wiki/Pholedrine" title="Pholedrine">Pholedrine</a></li> <li><a href="/wiki/Phenethylamine" title="Phenethylamine">Phenethylamine</a></li> <li><a href="/wiki/Pholedrine" title="Pholedrine">Pholedrine</a></li> <li><a href="/wiki/Phenpromethamine" title="Phenpromethamine">Phenpromethamine</a></li> <li><a href="/wiki/Prenylamine" title="Prenylamine">Prenylamine</a></li> <li><a href="/wiki/Propylamphetamine" title="Propylamphetamine">Propylamphetamine</a></li> <li><a href="/wiki/Pseudoephedrine" title="Pseudoephedrine">Pseudoephedrine</a></li> <li><a href="/wiki/Tiflorex" title="Tiflorex">Tiflorex</a></li> <li><a href="/wiki/Tyramine" title="Tyramine">Tyramine</a></li> <li><a href="/wiki/Xylopropamine" title="Xylopropamine">Xylopropamine</a></li> <li><a href="/wiki/Zylofuramine" title="Zylofuramine">Zylofuramine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Piperazines:</i> <a href="/wiki/2C-B-BZP" title="2C-B-BZP">2C-B-BZP</a></li> <li><a href="/wiki/Benzylpiperazine" title="Benzylpiperazine">BZP</a></li> <li><a href="/wiki/Methylbenzylpiperazine" title="Methylbenzylpiperazine">MBZP</a></li> <li><a href="/wiki/Methylenedioxybenzylpiperazine" title="Methylenedioxybenzylpiperazine">MDBZP</a></li> <li><a href="/wiki/Para-Methoxyphenylpiperazine" title="Para-Methoxyphenylpiperazine">MeOPP</a></li> <li><a href="/wiki/Ortho-Methylphenylpiperazine" title="Ortho-Methylphenylpiperazine">oMPP</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Others:</i> <a href="/wiki/2-Amino-1,2-dihydronaphthalene" title="2-Amino-1,2-dihydronaphthalene">2-ADN</a></li> <li><a href="/wiki/2-Aminoindane" title="2-Aminoindane">2-AI</a></li> <li><a href="/wiki/2-Aminotetralin" title="2-Aminotetralin">2-AT</a></li> <li><a href="/wiki/4-Benzylpiperidine" title="4-Benzylpiperidine">4-BP</a></li> <li><a href="/wiki/5-APDI" title="5-APDI">5-APDI</a></li> <li><a href="/wiki/5-IAI" title="5-IAI">5-IAI</a></li> <li><a href="/wiki/Amineptine" title="Amineptine">Amineptine</a></li> <li><a href="/wiki/Clofenciclan" title="Clofenciclan">Clofenciclan</a></li> <li><a href="/wiki/Cyclopentamine" title="Cyclopentamine">Cyclopentamine</a></li> <li><a href="/wiki/Cypenamine" title="Cypenamine">Cypenamine</a></li> <li><a href="/wiki/Cyprodenate" title="Cyprodenate">Cyprodenate</a></li> <li><a href="/wiki/Feprosidnine" title="Feprosidnine">Feprosidnine</a></li> <li><a href="/wiki/Gilutensin" class="mw-redirect" title="Gilutensin">Gilutensin</a></li> <li><a href="/wiki/Heptaminol" title="Heptaminol">Heptaminol</a></li> <li><a href="/wiki/Hexacyclonate" title="Hexacyclonate">Hexacyclonate</a></li> <li><a href="/wiki/Indanorex" title="Indanorex">Indanorex</a></li> <li><a href="/wiki/Isometheptene" title="Isometheptene">Isometheptene</a></li> <li><a href="/wiki/Methylhexanamine" title="Methylhexanamine">Methylhexanamine</a></li> <li><a href="/wiki/Naphthylaminopropane" title="Naphthylaminopropane">Naphthylaminopropane</a></li> <li><a href="/wiki/Octodrine" title="Octodrine">Octodrine</a></li> <li><a href="/wiki/Phthalimidopropiophenone" title="Phthalimidopropiophenone">Phthalimidopropiophenone</a></li> <li><a href="/wiki/Phenylbiguanide" title="Phenylbiguanide">Phenylbiguanide</a></li> <li><a href="/wiki/Propylhexedrine" title="Propylhexedrine">Propylhexedrine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Norepinephrine_releasing_agents" class="mw-redirect" title="Norepinephrine releasing agents"><abbr title="Norepinephrine releasing agents">NRAs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Norepinephrine releasing agents</span></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Morpholines:</i> <a href="/wiki/Fenbutrazate" title="Fenbutrazate">Fenbutrazate</a></li> <li><a href="/wiki/Fenmetramide" title="Fenmetramide">Fenmetramide</a></li> <li><a href="/wiki/Morazone" title="Morazone">Morazone</a></li> <li><a href="/wiki/Morforex" title="Morforex">Morforex</a></li> <li><a href="/wiki/Phendimetrazine" title="Phendimetrazine">Phendimetrazine</a></li> <li><a href="/wiki/Phenmetrazine" title="Phenmetrazine">Phenmetrazine</a></li> <li><a href="/wiki/Pseudophenmetrazine" title="Pseudophenmetrazine">Pseudophenmetrazine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Oxazolines:</i> <a href="/wiki/4-Methylaminorex" title="4-Methylaminorex">4-MAR</a></li> <li><a href="/wiki/Aminorex" title="Aminorex">Aminorex</a></li> <li><a href="/wiki/Clominorex" title="Clominorex">Clominorex</a></li> <li><a href="/wiki/Cyclazodone" title="Cyclazodone">Cyclazodone</a></li> <li><a href="/wiki/Fenozolone" title="Fenozolone">Fenozolone</a></li> <li><a href="/wiki/Fluminorex" title="Fluminorex">Fluminorex</a></li> <li><a href="/wiki/Pemoline" title="Pemoline">Pemoline</a></li> <li><a href="/wiki/Thozalinone" title="Thozalinone">Thozalinone</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Phenethylamines:</i> <a href="/wiki/Phenylethanolamine" title="Phenylethanolamine">2-OH-PEA</a></li> <li><a href="/wiki/4-Chlorophenylisobutylamine" title="4-Chlorophenylisobutylamine">4-CAB</a></li> <li><a href="/wiki/4-Fluoroamphetamine" title="4-Fluoroamphetamine">4-FA</a></li> <li><a href="/wiki/4-Fluoromethamphetamine" title="4-Fluoromethamphetamine">4-FMA</a></li> <li><a href="/wiki/4-Methylamphetamine" title="4-Methylamphetamine">4-MA</a></li> <li><a href="/wiki/4-Methylmethamphetamine" class="mw-redirect" title="4-Methylmethamphetamine">4-MMA</a></li> <li><a href="/wiki/Alfetamine" title="Alfetamine">Alfetamine</a></li> <li><a href="/wiki/Amfecloral" title="Amfecloral">Amfecloral</a></li> <li><a href="/wiki/Amfepentorex" title="Amfepentorex">Amfepentorex</a></li> <li><a href="/wiki/Amfepramone" title="Amfepramone">Amfepramone</a></li> <li><a href="/wiki/Amphetamine" title="Amphetamine">Amphetamine</a> <ul><li><a href="/wiki/Dextroamphetamine" title="Dextroamphetamine">Dextroamphetamine</a></li> <li><a href="/wiki/Levoamphetamine" title="Levoamphetamine">Levoamphetamine</a></li></ul></li> <li><a href="/wiki/Amphetaminil" class="mw-redirect" title="Amphetaminil">Amphetaminil</a></li> <li><a href="/wiki/%CE%92-Methylphenethylamine" title="Β-Methylphenethylamine">β-Me-PEA</a></li> <li><a href="/wiki/1,3-Benzodioxolylbutanamine" title="1,3-Benzodioxolylbutanamine">BDB</a></li> <li><a href="/wiki/Benzphetamine" title="Benzphetamine">Benzphetamine</a></li> <li><a href="/wiki/BOH_(drug)" title="BOH (drug)">BOH</a></li> <li><a href="/wiki/Buphedrone" title="Buphedrone">Buphedrone</a></li> <li><a href="/wiki/Butylone" title="Butylone">Butylone</a></li> <li><a href="/wiki/Cathine" title="Cathine">Cathine</a></li> <li><a href="/wiki/Cathinone" title="Cathinone">Cathinone</a></li> <li><a href="/wiki/Clobenzorex" title="Clobenzorex">Clobenzorex</a></li> <li><a href="/wiki/Clortermine" title="Clortermine">Clortermine</a></li> <li><a href="/wiki/Dimethylamphetamine" title="Dimethylamphetamine">Dimethylamphetamine</a></li> <li><a href="/wiki/Dimethoxyamphetamine" title="Dimethoxyamphetamine">DMA</a></li> <li><a href="/wiki/Dimethoxymethamphetamine" title="Dimethoxymethamphetamine">DMMA</a></li> <li><a href="/wiki/1,3-Benzodioxolyl-N-ethylbutanamine" title="1,3-Benzodioxolyl-N-ethylbutanamine">EBDB</a></li> <li><a href="/wiki/Ephedrine" title="Ephedrine">Ephedrine</a></li> <li><a href="/wiki/Ethcathinone" title="Ethcathinone">Ethcathinone</a></li> <li><a href="/wiki/Ethylone" title="Ethylone">Ethylone</a></li> <li><a href="/wiki/Etilamfetamine" title="Etilamfetamine">Etilamfetamine</a></li> <li><a href="/wiki/Famprofazone" title="Famprofazone">Famprofazone</a></li> <li><a href="/wiki/Fenethylline" title="Fenethylline">Fenethylline</a></li> <li><a href="/wiki/Fenproporex" title="Fenproporex">Fenproporex</a></li> <li><a href="/wiki/Flephedrone" title="Flephedrone">Flephedrone</a></li> <li><a href="/wiki/Fludorex" title="Fludorex">Fludorex</a></li> <li><a href="/wiki/Furfenorex" title="Furfenorex">Furfenorex</a></li> <li><a href="/wiki/Hordenine" title="Hordenine">Hordenine</a></li> <li><a href="/wiki/4-Hydroxyamphetamine" title="4-Hydroxyamphetamine">4-Hydroxyamphetamine</a></li> <li><a href="/wiki/5-APDI" title="5-APDI">5-APDI</a> (IAP)</li> <li><a href="/wiki/Iofetamine_(123I)" title="Iofetamine (123I)">Iofetamine (123I)</a></li> <li><a href="/wiki/Lisdexamfetamine" title="Lisdexamfetamine">Lisdexamfetamine</a></li> <li><a href="/wiki/Lophophine" title="Lophophine">Lophophine</a></li> <li><a href="/wiki/1,3-Benzodioxolyl-N-methylbutanamine" class="mw-redirect" title="1,3-Benzodioxolyl-N-methylbutanamine">MBDB</a></li> <li><a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a></li> <li><a href="/wiki/Methylenedioxyethylamphetamine" class="mw-redirect" title="Methylenedioxyethylamphetamine">MDEA</a></li> <li><a href="/wiki/MDMA" title="MDMA">MDMA (midomafetamine)</a></li> <li><a href="/wiki/Metamfepramone" title="Metamfepramone">Metamfepramone</a></li> <li><a href="/wiki/Methylenedioxymethylphenethylamine" class="mw-redirect" title="Methylenedioxymethylphenethylamine">MDMPEA</a></li> <li><a href="/wiki/Methylenedioxyhydroxyamphetamine" class="mw-redirect" title="Methylenedioxyhydroxyamphetamine">MDOH</a></li> <li><a href="/wiki/Methylenedioxyphenethylamine" class="mw-redirect" title="Methylenedioxyphenethylamine">MDPEA</a></li> <li><a href="/wiki/Mefenorex" title="Mefenorex">Mefenorex</a></li> <li><a href="/wiki/Mephedrone" title="Mephedrone">Mephedrone</a></li> <li><a href="/wiki/Mephentermine" title="Mephentermine">Mephentermine</a></li> <li><a href="/wiki/Methamphetamine" title="Methamphetamine">Methamphetamine</a> <ul><li><a href="/wiki/Dextromethamphetamine" class="mw-redirect" title="Dextromethamphetamine">Dextromethamphetamine</a></li> <li><a href="/wiki/Levomethamphetamine" class="mw-redirect" title="Levomethamphetamine">Levomethamphetamine</a></li></ul></li> <li><a href="/wiki/Methcathinone" title="Methcathinone">Methcathinone</a></li> <li><a href="/wiki/Methedrone" title="Methedrone">Methedrone</a></li> <li><a href="/wiki/Methylone" title="Methylone">Methylone</a></li> <li><a href="/wiki/Morforex" title="Morforex">Morforex</a></li> <li><a href="/wiki/Naphthylaminopropane" title="Naphthylaminopropane">Naphthylaminopropane</a></li> <li><a href="/wiki/Ortetamine" title="Ortetamine">Ortetamine</a></li> <li><a href="/wiki/Para-Bromoamphetamine" title="Para-Bromoamphetamine"><i>p</i>BA</a></li> <li><a href="/wiki/Para-Chloroamphetamine" title="Para-Chloroamphetamine"><i>p</i>CA</a></li> <li><a href="/wiki/Pentorex" title="Pentorex">Pentorex</a></li> <li><a href="/wiki/Phenethylamine" title="Phenethylamine">Phenethylamine</a></li> <li><a href="/wiki/Pholedrine" title="Pholedrine">Pholedrine</a></li> <li><a href="/wiki/Phenpromethamine" title="Phenpromethamine">Phenpromethamine</a></li> <li><a href="/wiki/Phentermine" title="Phentermine">Phentermine</a></li> <li><a href="/wiki/Phenylpropanolamine" title="Phenylpropanolamine">Phenylpropanolamine</a></li> <li><a href="/wiki/Para-Iodoamphetamine" title="Para-Iodoamphetamine"><i>p</i>IA</a></li> <li><a href="/wiki/Prenylamine" title="Prenylamine">Prenylamine</a></li> <li><a href="/wiki/Propylamphetamine" title="Propylamphetamine">Propylamphetamine</a></li> <li><a href="/wiki/Pseudoephedrine" title="Pseudoephedrine">Pseudoephedrine</a></li> <li><a href="/wiki/Selegiline" title="Selegiline">Selegiline</a> (also <a href="/wiki/D-Deprenyl" title="D-Deprenyl"><span style="font-size:85%;">D</span>-Deprenyl</a>)</li> <li><a href="/wiki/Tiflorex" title="Tiflorex">Tiflorex</a></li> <li><a href="/wiki/Tyramine" title="Tyramine">Tyramine</a></li> <li><a href="/wiki/Xylopropamine" title="Xylopropamine">Xylopropamine</a></li> <li><a href="/wiki/Zylofuramine" title="Zylofuramine">Zylofuramine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Piperazines:</i> <a href="/wiki/2C-B-BZP" title="2C-B-BZP">2C-B-BZP</a></li> <li><a href="/wiki/Benzylpiperazine" title="Benzylpiperazine">BZP</a></li> <li><a href="/wiki/Methylbenzylpiperazine" title="Methylbenzylpiperazine">MBZP</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/Methylenedioxybenzylpiperazine" title="Methylenedioxybenzylpiperazine">MDBZP</a></li> <li><a href="/wiki/Para-Methoxyphenylpiperazine" title="Para-Methoxyphenylpiperazine">MeOPP</a></li> <li><a href="/wiki/Ortho-Methylphenylpiperazine" title="Ortho-Methylphenylpiperazine">oMPP</a></li> <li><a href="/wiki/Para-Fluorophenylpiperazine" title="Para-Fluorophenylpiperazine">pFPP</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0;text-align: left;"><div style="padding:0 0.25em"> <ul><li><i>Others:</i> <a href="/wiki/2-Amino-1,2-dihydronaphthalene" title="2-Amino-1,2-dihydronaphthalene">2-ADN</a></li> <li><a href="/wiki/2-Aminoindane" title="2-Aminoindane">2-AI</a></li> <li><a href="/wiki/2-Aminotetralin" title="2-Aminotetralin">2-AT</a></li> <li><a href="/wiki/2-Benzylpiperidine" title="2-Benzylpiperidine">2-BP</a></li> <li><a href="/wiki/4-Benzylpiperidine" title="4-Benzylpiperidine">4-BP</a></li> <li><a href="/wiki/5-IAI" title="5-IAI">5-IAI</a></li> <li><a href="/wiki/Clofenciclan" title="Clofenciclan">Clofenciclan</a></li> <li><a href="/wiki/Cyclopentamine" title="Cyclopentamine">Cyclopentamine</a></li> <li><a href="/wiki/Cypenamine" title="Cypenamine">Cypenamine</a></li> <li><a href="/wiki/Cyprodenate" title="Cyprodenate">Cyprodenate</a></li> <li><a href="/wiki/Feprosidnine" title="Feprosidnine">Feprosidnine</a></li> <li><a href="/wiki/Gilutensin" class="mw-redirect" title="Gilutensin">Gilutensin</a></li> <li><a href="/wiki/Heptaminol" title="Heptaminol">Heptaminol</a></li> <li><a href="/wiki/Hexacyclonate" title="Hexacyclonate">Hexacyclonate</a></li> <li><a href="/wiki/Indanorex" title="Indanorex">Indanorex</a></li> <li><a href="/wiki/Isometheptene" title="Isometheptene">Isometheptene</a></li> <li><a href="/wiki/Methylhexanamine" title="Methylhexanamine">Methylhexanamine</a></li> <li><a href="/wiki/Octodrine" title="Octodrine">Octodrine</a></li> <li><a href="/wiki/Phthalimidopropiophenone" title="Phthalimidopropiophenone">Phthalimidopropiophenone</a></li> <li><a href="/wiki/Propylhexedrine" title="Propylhexedrine">Propylhexedrine</a></li> <li><a href="/wiki/Tuaminoheptane" title="Tuaminoheptane">Tuaminoheptane</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Serotonin_releasing_agents" class="mw-redirect" title="Serotonin releasing agents"><abbr title="Serotonin releasing agents">SRAs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Serotonin releasing agents</span></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Aminoindanes:</i> <a href="/wiki/5-IAI" title="5-IAI">5-IAI</a></li> <li><a href="/wiki/1-Aminomethyl-5-methoxyindane" title="1-Aminomethyl-5-methoxyindane">AMMI</a></li> <li><a href="/wiki/Ethyltrifluoromethylaminoindane" title="Ethyltrifluoromethylaminoindane">ETAI</a></li> <li><a href="/wiki/MDAI" title="MDAI">MDAI</a></li> <li><a href="/wiki/MDMAI" title="MDMAI">MDMAI</a></li> <li><a href="/wiki/MMAI" title="MMAI">MMAI</a></li> <li><a href="/wiki/Trifluoromethylaminoindane" title="Trifluoromethylaminoindane">TAI</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Aminotetralins:</i> <a href="/wiki/6-CAT" title="6-CAT">6-CAT</a></li> <li><a href="/wiki/8-OH-DPAT" title="8-OH-DPAT">8-OH-DPAT</a></li> <li><a href="/wiki/MDAT" title="MDAT">MDAT</a></li> <li><a href="/wiki/MDMAT" title="MDMAT">MDMAT</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Oxazolines:</i> <a href="/wiki/4-Methylaminorex" title="4-Methylaminorex">4-Methylaminorex</a></li> <li><a href="/wiki/Aminorex" title="Aminorex">Aminorex</a></li> <li><a href="/wiki/Clominorex" title="Clominorex">Clominorex</a></li> <li><a href="/wiki/Fluminorex" title="Fluminorex">Fluminorex</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Phenethylamines:</i> <a href="/wiki/2-Methyl-MDA" title="2-Methyl-MDA">2-Methyl-MDA</a></li> <li><a href="/wiki/4-Chlorophenylisobutylamine" title="4-Chlorophenylisobutylamine">4-CAB</a></li> <li><a href="/wiki/4-Fluoroamphetamine" title="4-Fluoroamphetamine">4-FA</a></li> <li><a href="/wiki/4-Fluoromethamphetamine" title="4-Fluoromethamphetamine">4-FMA</a></li> <li><a href="/wiki/4-Hydroxyamphetamine" title="4-Hydroxyamphetamine">4-HA</a></li> <li><a href="/wiki/4-Methylthioamphetamine" title="4-Methylthioamphetamine">4-MTA</a></li> <li><a href="/wiki/5-APDB" title="5-APDB">5-APDB</a></li> <li><a href="/wiki/5-Methyl-MDA" title="5-Methyl-MDA">5-Methyl-MDA</a></li> <li><a href="/wiki/6-APDB" title="6-APDB">6-APDB</a></li> <li><a href="/wiki/6-Methyl-MDA" title="6-Methyl-MDA">6-Methyl-MDA</a></li> <li><a href="/wiki/3-Methoxy-4-methyl-%CE%B1-ethylphenethylamine" class="mw-redirect" title="3-Methoxy-4-methyl-α-ethylphenethylamine">AEMMA</a></li> <li><a href="/wiki/Amiflamine" title="Amiflamine">Amiflamine</a></li> <li><a href="/wiki/Benzodioxolylbutanamine" class="mw-redirect" title="Benzodioxolylbutanamine">BDB</a></li> <li><a href="/wiki/BOH_(drug)" title="BOH (drug)">BOH</a></li> <li><a href="/wiki/4-Bromomethcathinone" title="4-Bromomethcathinone">Brephedrone</a></li> <li><a href="/wiki/Butylone" title="Butylone">Butylone</a></li> <li><a href="/wiki/Chlorphentermine" title="Chlorphentermine">Chlorphentermine</a></li> <li><a href="/wiki/Cloforex" title="Cloforex">Cloforex</a></li> <li><a href="/wiki/Amfepramone" title="Amfepramone">Amfepramone</a></li> <li><a href="/wiki/Metamfepramone" title="Metamfepramone">Metamfepramone</a></li> <li><a href="/wiki/3,4-Dichloroamphetamine" title="3,4-Dichloroamphetamine">DCA</a></li> <li><a href="/wiki/Dexfenfluramine" title="Dexfenfluramine">Dexfenfluramine</a></li> <li><a href="/wiki/DFMDA" title="DFMDA">DFMDA</a></li> <li><a href="/wiki/Dimethoxyamphetamine" title="Dimethoxyamphetamine">DMA</a></li> <li><a href="/wiki/Dimethoxymethamphetamine" title="Dimethoxymethamphetamine">DMMA</a></li> <li><a href="/wiki/Ethylbenzodioxolylbutanamine" class="mw-redirect" title="Ethylbenzodioxolylbutanamine">EBDB</a></li> <li><a href="/wiki/EDMA" title="EDMA">EDMA</a></li> <li><a href="/wiki/Ethylone" title="Ethylone">Ethylone</a></li> <li><a href="/wiki/Etolorex" title="Etolorex">Etolorex</a></li> <li><a href="/wiki/Fenfluramine" title="Fenfluramine">Fenfluramine</a></li> <li><a href="/wiki/Flephedrone" title="Flephedrone">Flephedrone</a></li> <li><a href="/wiki/Flucetorex" title="Flucetorex">Flucetorex</a></li> <li><a href="/wiki/Indanylaminopropane" class="mw-redirect" title="Indanylaminopropane">IAP</a></li> <li><a href="/wiki/Iofetamine" class="mw-redirect" title="Iofetamine">Iofetamine</a></li> <li><a href="/wiki/Levofenfluramine" title="Levofenfluramine">Levofenfluramine</a></li> <li><a href="/wiki/Lophophine" title="Lophophine">Lophophine</a></li> <li><a href="/wiki/Methylbenzodioxolylbutanamine" class="mw-redirect" title="Methylbenzodioxolylbutanamine">MBDB</a></li> <li><a href="/wiki/3,4-Methylenedioxyamphetamine" title="3,4-Methylenedioxyamphetamine">MDA (tenamfetamine)</a></li> <li><a href="/wiki/Methylenedioxyethylamphetamine" class="mw-redirect" title="Methylenedioxyethylamphetamine">MDEA</a></li> <li><a href="/wiki/Methylenedioxyhydroxymethamphetamine" class="mw-redirect" title="Methylenedioxyhydroxymethamphetamine">MDHMA</a></li> <li><a href="/wiki/MDMA" title="MDMA">MDMA (midomafetamine)</a></li> <li><a href="/wiki/Methylenedioxymethylphenethylamine" class="mw-redirect" title="Methylenedioxymethylphenethylamine">MDMPEA</a></li> <li><a href="/wiki/Methylenedioxyhydroxyamphetamine" class="mw-redirect" title="Methylenedioxyhydroxyamphetamine">MDOH</a></li> <li><a href="/wiki/Methylenedioxyphenethylamine" class="mw-redirect" title="Methylenedioxyphenethylamine">MDPEA</a></li> <li><a href="/wiki/Mephedrone" title="Mephedrone">Mephedrone</a></li> <li><a href="/wiki/Methedrone" title="Methedrone">Methedrone</a></li> <li><a href="/wiki/Methylone" title="Methylone">Methylone</a></li> <li><a href="/wiki/3-Methoxy-4-methylamphetamine" title="3-Methoxy-4-methylamphetamine">MMA</a></li> <li><a href="/wiki/MMDA_(drug)" title="MMDA (drug)">MMDA</a></li> <li><a href="/wiki/MMDMA" title="MMDMA">MMDMA</a></li> <li><a href="/wiki/3-Methoxy-4-methylmethamphetamine" class="mw-redirect" title="3-Methoxy-4-methylmethamphetamine">MMMA</a></li> <li><a href="/wiki/Naphthylaminopropane" title="Naphthylaminopropane">NAP</a></li> <li><a href="/wiki/Norfenfluramine" title="Norfenfluramine">Norfenfluramine</a></li> <li><a href="/wiki/4-Trifluoromethylamphetamine" class="mw-redirect" title="4-Trifluoromethylamphetamine">4-TFMA</a></li> <li><a href="/wiki/Para-Bromoamphetamine" title="Para-Bromoamphetamine">pBA</a></li> <li><a href="/wiki/Para-Chloroamphetamine" title="Para-Chloroamphetamine">pCA</a></li> <li><a href="/wiki/Para-Iodoamphetamine" title="Para-Iodoamphetamine">pIA</a></li> <li><a href="/wiki/Para-Methoxyamphetamine" title="Para-Methoxyamphetamine">PMA</a></li> <li><a href="/wiki/Para-Methoxyethylamphetamine" class="mw-redirect" title="Para-Methoxyethylamphetamine">PMEA</a></li> <li><a href="/wiki/Para-Methoxymethamphetamine" class="mw-redirect" title="Para-Methoxymethamphetamine">PMMA</a></li> <li><a href="/wiki/Tetralinylaminopropane" class="mw-redirect" title="Tetralinylaminopropane">TAP</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Piperazines:</i> <a href="/wiki/2C-B-BZP" title="2C-B-BZP">2C-B-BZP</a></li> <li><a href="/w/index.php?title=3-Methoxyphenylpiperazine&action=edit&redlink=1" class="new" title="3-Methoxyphenylpiperazine (page does not exist)">3-MeOPP</a></li> <li><a href="/wiki/Benzylpiperazine" title="Benzylpiperazine">BZP</a></li> <li><a href="/wiki/3,4-Dichlorophenylpiperazine" class="mw-redirect" title="3,4-Dichlorophenylpiperazine">DCPP</a></li> <li><a href="/wiki/Methylbenzylpiperazine" title="Methylbenzylpiperazine">MBZP</a></li> <li><a href="/wiki/Meta-Chlorophenylpiperazine" title="Meta-Chlorophenylpiperazine">mCPP</a></li> <li><a href="/wiki/Methylenedioxybenzylpiperazine" title="Methylenedioxybenzylpiperazine">MDBZP</a></li> <li><a href="/wiki/Para-Methoxyphenylpiperazine" title="Para-Methoxyphenylpiperazine">MeOPP</a></li> <li><a href="/wiki/Mepiprazole" title="Mepiprazole">Mepiprazole</a></li> <li><a href="/wiki/Ortho-Methylphenylpiperazine" title="Ortho-Methylphenylpiperazine">oMPP</a></li> <li><a href="/wiki/Para-Chlorophenylpiperazine" title="Para-Chlorophenylpiperazine">pCPP</a></li> <li><a href="/wiki/Para-Fluorophenylpiperazine" title="Para-Fluorophenylpiperazine">pFPP</a></li> <li><a href="/wiki/1-(4-Trifluoromethyl-phenyl)-piperazine" class="mw-redirect" title="1-(4-Trifluoromethyl-phenyl)-piperazine">pTFMPP</a></li> <li><a href="/wiki/Trifluoromethylphenylpiperazine" title="Trifluoromethylphenylpiperazine">TFMPP</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Tryptamines:</i> <a href="/wiki/4-Methyl-AET" class="mw-redirect" title="4-Methyl-AET">4-Methyl-αET</a></li> <li><a href="/wiki/4-Methyl-AMT" class="mw-redirect" title="4-Methyl-AMT">4-Methyl-αMT</a></li> <li><a href="/wiki/5-Carboxamidotryptamine" title="5-Carboxamidotryptamine">5-CT</a></li> <li><a href="/wiki/5-MeO-AET" title="5-MeO-AET">5-MeO-αET</a></li> <li><a href="/wiki/5-MeO-AMT" class="mw-redirect" title="5-MeO-AMT">5-MeO-αMT</a></li> <li><a href="/wiki/5-Methoxytryptamine" title="5-Methoxytryptamine">5-MT</a></li> <li><a href="/wiki/Alpha-Ethyltryptamine" class="mw-redirect" title="Alpha-Ethyltryptamine">αET</a></li> <li><a href="/wiki/Alpha-Methyltryptamine" class="mw-redirect" title="Alpha-Methyltryptamine">αMT</a></li> <li><a href="/wiki/Dimethyltryptamine" class="mw-redirect" title="Dimethyltryptamine">DMT</a></li> <li><a href="/wiki/Tryptamine" title="Tryptamine">Tryptamine</a></li></ul> </div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Others:</i> <a href="/wiki/Indeloxazine" title="Indeloxazine">Indeloxazine</a></li> <li><a href="/wiki/Viqualine" title="Viqualine">Viqualine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>DAT modulators:</i> <i>Agonist-like:</i> <a href="/wiki/SoRI-9804" title="SoRI-9804">SoRI-9804</a></li> <li><a href="/w/index.php?title=SoRI-20040&action=edit&redlink=1" class="new" title="SoRI-20040 (page does not exist)">SoRI-20040</a>; <i>Antagonist-like:</i> <a href="/wiki/SoRI-20041" title="SoRI-20041">SoRI-20041</a></li></ul> <ul><li><i>Adrenergic release blockers:</i> <a href="/wiki/Bethanidine" title="Bethanidine">Bethanidine</a></li> <li><a href="/wiki/Bretylium" title="Bretylium">Bretylium</a></li> <li><a href="/wiki/Guanadrel" title="Guanadrel">Guanadrel</a></li> <li><a href="/wiki/Guanazodine" title="Guanazodine">Guanazodine</a></li> <li><a href="/wiki/Guanethidine" title="Guanethidine">Guanethidine</a></li> <li><a href="/wiki/Guanoxan" title="Guanoxan">Guanoxan</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><small><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a> • <a href="/wiki/Template:Monoamine_reuptake_inhibitors" title="Template:Monoamine reuptake inhibitors">Monoamine reuptake inhibitors</a> • <a href="/wiki/Template:Adrenergics" class="mw-redirect" title="Template:Adrenergics">Adrenergics</a> • <a href="/wiki/Template:Dopaminergics" class="mw-redirect" title="Template:Dopaminergics">Dopaminergics</a> • <a href="/wiki/Template:Serotonergics" class="mw-redirect" title="Template:Serotonergics">Serotonergics</a> • <a href="/wiki/Template:Monoamine_metabolism_modulators" title="Template:Monoamine metabolism modulators">Monoamine metabolism modulators</a> • <a href="/wiki/Template:Monoamine_neurotoxins" title="Template:Monoamine neurotoxins">Monoamine neurotoxins</a></i></small></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Amphetamine" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Amphetamine" title="Template:Amphetamine"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Amphetamine" title="Template talk:Amphetamine"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Amphetamine" title="Special:EditPage/Template:Amphetamine"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Amphetamine" style="font-size:114%;margin:0 4em"><a href="/wiki/Amphetamine" title="Amphetamine">Amphetamine</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center">Main articles <br />and <br />pharmaceuticals</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10.5em"><a href="/wiki/Amphetamine" title="Amphetamine">Amphetamine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Adzenys ER</i></li> <li><i><span class="nowrap">Adzenys XR-ODT</span></i></li> <li><i>Dyanavel XR</i></li> <li><i>Evekeo</i></li> <li><i>Evekeo ODT</i></li> <li>Mixed amphetamine salts <ul><li><i><a href="/wiki/Adderall" title="Adderall">Adderall</a></i></li> <li><i>Adderall XR</i></li> <li><i>Mydayis</i></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10.5em"><a href="/wiki/Levoamphetamine" title="Levoamphetamine">Levoamphetamine</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em">N/A</div></td></tr><tr><th scope="row" class="navbox-group" style="width:10.5em"><a href="/wiki/Dextroamphetamine" title="Dextroamphetamine">Dextroamphetamine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Dexedrine</i></li> <li><i>ProCentra</i></li> <li><i>Zenzedi</i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10.5em"><a href="/wiki/Lisdexamfetamine" title="Lisdexamfetamine">Lisdexamfetamine</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Vyvanse</i></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center">Neuropharmacology</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:10.5em"><a href="/wiki/Biological_target" title="Biological target">Biomolecular targets</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TAAR1" title="TAAR1">TAAR1</a> (<a href="/wiki/Agonist#Types_of_agonists" title="Agonist">full agonist</a>)</li> <li><a href="/wiki/Cocaine_and_amphetamine_regulated_transcript" title="Cocaine and amphetamine regulated transcript">CART</a> (<a href="/wiki/Messenger_RNA" title="Messenger RNA"><abbr title="messenger RNA">mRNA</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip messenger RNA</span> inducer)</li> <li><a href="/wiki/5-HT1A_receptor" title="5-HT1A receptor">5-HT1A receptor</a> (low affinity <a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">ligand</a>)</li> <li><a href="/wiki/Monoamine_oxidase" title="Monoamine oxidase">MAO</a> (weak <a href="/wiki/Competitive_inhibition" title="Competitive inhibition">competitive inhibitor</a>)</li> <li><a href="/wiki/Carbonic_anhydrase" title="Carbonic anhydrase">Carbonic anhydrases</a> <a href="/wiki/Carbonic_anhydrase_4" title="Carbonic anhydrase 4">hCA4</a>, <a href="/wiki/Carbonic_anhydrase_5A" class="mw-redirect" title="Carbonic anhydrase 5A">hCA5A</a>, <a href="/wiki/Carbonic_anhydrase_5B" class="mw-redirect" title="Carbonic anhydrase 5B">hCA5B</a>, <a href="/wiki/Carbonic_anhydrase_7" title="Carbonic anhydrase 7">hCA7</a>, <a href="/wiki/Carbonic_anhydrase_12" title="Carbonic anhydrase 12">hCA12</a>, <a href="/wiki/Carbonic_anhydrase_13" title="Carbonic anhydrase 13">hCA13</a>, and <a href="/wiki/Carbonic_anhydrase_14" title="Carbonic anhydrase 14">hCA14</a> (<a href="/wiki/Enzyme_activator" title="Enzyme activator">enzyme activator</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:10.5em">Inhibited <a href="/wiki/Membrane_transport_protein" title="Membrane transport protein">transporters</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">DAT</a></li> <li><a href="/wiki/Norepinephrine_transporter" title="Norepinephrine transporter">NET</a></li> <li><a href="/wiki/Serotonin_transporter" title="Serotonin transporter">SERT</a></li> <li><a href="/wiki/Vesicular_monoamine_transporter_1" title="Vesicular monoamine transporter 1">VMAT1</a></li> <li><a href="/wiki/Vesicular_monoamine_transporter_2" title="Vesicular monoamine transporter 2">VMAT2</a></li> <li><a href="/wiki/Glutamate_transporter#EAATs" title="Glutamate transporter">EAAT3</a></li> <li><a href="/wiki/SLC22A3" title="SLC22A3">SLC22A3</a></li> <li><a href="/wiki/SLC22A5" title="SLC22A5">SLC22A5</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center">Active metabolites</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/4-Hydroxyamphetamine" title="4-Hydroxyamphetamine">4-Hydroxyamphetamine</a></li> <li><a href="/wiki/P-Hydroxynorephedrine" title="P-Hydroxynorephedrine">4-Hydroxynorephedrine</a></li> <li><a href="/wiki/Phenylpropanolamine" title="Phenylpropanolamine">Norephedrine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align: center">Related articles</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Attention_deficit_hyperactivity_disorder" title="Attention deficit hyperactivity disorder">ADHD</a></li> <li><a href="/wiki/Attention_deficit_hyperactivity_disorder_management" class="mw-redirect" title="Attention deficit hyperactivity disorder management">ADHD management</a></li> <li><a href="/wiki/Stimulant_psychosis#Substituted_amphetamines" title="Stimulant psychosis">Amphetamine psychosis</a></li> <li><a href="/wiki/Benzedrine_in_popular_culture" class="mw-redirect" title="Benzedrine in popular culture">Benzedrine in popular culture</a></li> <li><a href="/wiki/Dopamine" title="Dopamine">Dopamine</a></li> <li><a href="/wiki/Doping_in_sport" title="Doping in sport">Doping in sport</a></li> <li><a href="/wiki/Executive_functions" title="Executive functions">Executive functions</a></li> <li><a href="/wiki/Formetorex" title="Formetorex">Formetorex</a></li> <li><a href="/wiki/FOSB#ΔFosB" title="FOSB">ΔFosB</a></li> <li><a href="/wiki/History_and_culture_of_substituted_amphetamines" title="History and culture of substituted amphetamines">History and culture of substituted amphetamines</a></li> <li><a href="/wiki/Methamphetamine" title="Methamphetamine">Methamphetamine</a></li> <li><a href="/wiki/Methylphenidate" title="Methylphenidate">Methylphenidate</a></li> <li><a href="/wiki/N-Methylphenethylamine" title="N-Methylphenethylamine"><i>N</i>-Methylphenethylamine</a></li> <li><a href="/wiki/Motivational_salience" title="Motivational salience">Motivational salience</a> <ul><li><a href="/wiki/Motivational_salience#Incentive_salience" title="Motivational salience">Incentive salience</a></li></ul></li> <li><a href="/wiki/Narcolepsy" title="Narcolepsy">Narcolepsy</a></li> <li><a href="/wiki/Neurobiological_effects_of_physical_exercise#Attention_deficit_hyperactivity_disorder" title="Neurobiological effects of physical exercise">Neurobiological effects of physical exercise § Attention deficit hyperactivity disorder</a></li> <li><a href="/wiki/Nootropic" title="Nootropic">Nootropic</a></li> <li><a href="/wiki/Norepinephrine" title="Norepinephrine">Norepinephrine</a></li> <li><a href="/wiki/Obesity" title="Obesity">Obesity</a></li> <li><a href="/wiki/Performance-enhancing_substance" title="Performance-enhancing substance">Performance-enhancing substance</a></li> <li><a href="/wiki/Phenethylamine" title="Phenethylamine">Phenethylamine</a></li> <li><a href="/wiki/Phentermine" title="Phentermine">Phentermine</a></li> <li><a href="/wiki/Phenylacetone" title="Phenylacetone">Phenylacetone</a></li> <li><a href="/wiki/Recreational_drug_use" title="Recreational drug use">Recreational drug use</a></li> <li><a href="/wiki/Serotonin" title="Serotonin">Serotonin</a></li> <li><a href="/wiki/Substituted_amphetamine" title="Substituted amphetamine">Substituted amphetamine</a></li> <li><a href="/wiki/Trace_amine" title="Trace amine">Trace amine</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow hlist" colspan="2"><div> <ul><li><span class="noviewer" typeof="mw:File"><span title="Category"><img alt="" src="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/16px-Symbol_category_class.svg.png" decoding="async" width="16" height="16" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/23px-Symbol_category_class.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/9/96/Symbol_category_class.svg/31px-Symbol_category_class.svg.png 2x" data-file-width="180" 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