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(PDF) Impact of dose-rate on the low-dose hyper-radiosensitivity and induced radioresistance (HRS/IRR) response* | Charles Thomas - Academia.edu

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Limited","grobid_abstract":"Purpose: To ask whether dose-rate influences low-dose hyper-radiosensitivity and induced radioresistance (HRS/IRR) response in rat colon carcinoma PRO and REG cells. Methods: Clonogenic survival was applied to tumourigenic PRO and non-tumourigenic REG cells irradiated with 60 Co -rays at 0.0025-500 mGy.min-1. Both clonogenic survival and non-homologous end-joining (NHEJ) pathway involved in DNA double-strand breaks (DSB) repair assays were applied to PRO cells irradiated at 25 mGy.min-1 with 75 kV X-rays only. Results: Irrespective of dose-rates, marked HRS/IRR responses were observed in PRO but not in REG cells. For PRO cells, the doses at which HRS and IRR responses are maximal were dependent on dose-rate; conversely exposure times during which HRS and IRR responses are maximal (t HRSmax and t IRRmax) were independent of dose-rate. The t HRSmax and t IRRmax values were 23±5s and 66±7s [mean±standard error of the mean (SEM), n=7), in agreement with literature data. Repair data show that t HRSmax may correspond to exposure time during which NHEJ is deficient while t IRRmax may correspond to exposure time during which NHEJ is complete. Conclusion: HRS response may be maximal if exposure times are shorter than t HRSmax irrespective of dose, dose-rate and cellular model. Potential application of HRS response in radiotherapy is discussed.","publication_date":"2013,,","publication_name":"International Journal of Radiation Biology","grobid_abstract_attachment_id":"70542198"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Impact of dose-rate on the low-dose hyper-radiosensitivity and induced radioresistance (HRS/IRR) response*","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [144159817]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div 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data-entity-id="30919383" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30919383/Human_In_vivo_Dose_Response_to_Controlled_Low_Dose_Low_Linear_Energy_Transfer_Ionizing_Radiation_Exposure">Human In vivo Dose-Response to Controlled, Low-Dose Low Linear Energy Transfer Ionizing Radiation Exposure</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="58854969" href="https://novartis.academia.edu/RuixiaoLu">Ruixiao Lu</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Cancer Research, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{&quot;location&quot;:&quot;wsj-grid-card-download-pdf-modal&quot;,&quot;work_title&quot;:&quot;Human In vivo Dose-Response to Controlled, Low-Dose Low Linear Energy 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