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{"work":{"id":26174975,"created_at":"2016-06-15T01:31:07.182-07:00","from_world_paper_id":154321491,"updated_at":"2024-11-12T06:20:20.305-08:00","_data":{"grobid_abstract":"Purpose: We tested whether the chromosomal radiosensitivity of in vitro irradiated lymphocytes could be used to predict the risk of acute reactions after radiotherapy. Methods and Materials: Two prospective studies were performed: study A with 51 patients included different tumor sites and study B included 87 breast cancer patients. Acute reaction was assessed using the Radiation Therapy Oncology Group score. In both studies, patients were treated with curative radiotherapy, and the mean tumor dose applied was 55 Gy (40-65) ± boost with 11 Gy (6-31) in study A and 50.4 Gy ± boost with 10 Gy in study B. Individual radiosensitivity was determined with lymphocytes irradiated in vitro with X-ray doses of either 3 or 6 Gy and scoring the number of chromosomal deletions. Results: Acute reactions displayed a typical spectrum with 57% in study A and 53% in study B showing an acute reaction of Grade 2-3. Individual radiosensitivity in both studies was characterized by a substantial variation and the fraction of patients with Grade 2-3 reaction was found to increase with increasing individual radiosensitivity measured at 6 Gy (study A, p = 0.238; study B, p = 0.023). For study B, this fraction increased with breast volume, and the impact of individual radiosensitivity on acute reaction was especially pronounced (p = 0.00025) for lower breast volume. No such clear association with acute reaction was observed when individual radiosensitivity was assessed at 3 Gy. Conclusion: Individual radiosensitivity determined at 6 Gy seems to be a good predictor for risk of acute effects after curative radiotherapy. Ó","publication_date":"2009,,","publication_name":"International Journal of Radiation Oncology Biology Physics","grobid_abstract_attachment_id":"46501147"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"INDIVIDUAL RADIOSENSITIVITY MEASURED WITH LYMPHOCYTES: LATE EFFECTS ARE THE KEY POINT: IN REGARD TO BORGMANN ET AL. (INT J RADlAT ONCOL BIOL PHYS 2008;71:256-264)","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [50075682]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":46501147,"attachmentType":"pdf"}"><img alt="First page of “INDIVIDUAL RADIOSENSITIVITY MEASURED WITH LYMPHOCYTES: LATE EFFECTS ARE THE KEY POINT: IN REGARD TO BORGMANN ET AL. (INT J RADlAT ONCOL BIOL PHYS 2008;71:256-264)”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/46501147/mini_magick20190209-15264-c263p4.png?1549755347" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">INDIVIDUAL RADIOSENSITIVITY MEASURED WITH LYMPHOCYTES: LATE EFFECTS ARE THE KEY POINT: IN REGARD TO BORGMANN ET AL. (INT J RADlAT ONCOL BIOL PHYS 2008;71:256-264)</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="50075682" href="https://independent.academia.edu/KerstinBorgmann"><img alt="Profile image of Kerstin Borgmann" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/50075682/163533442/153326749/s65_kerstin.borgmann.png" />Kerstin Borgmann</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2009, International Journal of Radiation Oncology Biology Physics</p></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":46501147,"attachmentType":"pdf","workUrl":"https://www.academia.edu/26174975/INDIVIDUAL_RADIOSENSITIVITY_MEASURED_WITH_LYMPHOCYTES_LATE_EFFECTS_ARE_THE_KEY_POINT_IN_REGARD_TO_BORGMANN_ET_AL_INT_J_RADlAT_ONCOL_BIOL_PHYS_2008_71_256_264_"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":46501147,"attachmentType":"pdf","workUrl":"https://www.academia.edu/26174975/INDIVIDUAL_RADIOSENSITIVITY_MEASURED_WITH_LYMPHOCYTES_LATE_EFFECTS_ARE_THE_KEY_POINT_IN_REGARD_TO_BORGMANN_ET_AL_INT_J_RADlAT_ONCOL_BIOL_PHYS_2008_71_256_264_"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="46501147" data-landing_url="https://www.academia.edu/26174975/INDIVIDUAL_RADIOSENSITIVITY_MEASURED_WITH_LYMPHOCYTES_LATE_EFFECTS_ARE_THE_KEY_POINT_IN_REGARD_TO_BORGMANN_ET_AL_INT_J_RADlAT_ONCOL_BIOL_PHYS_2008_71_256_264_" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="17735206" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17735206/Individual_Radiosensitivity_Measured_With_Lymphocytes_Late_Effects_Are_the_Key_Point_In_Regard_to_Borgmann_et_al_Int_J_Radiat_Oncol_Biol_Phys_2008_71_256_264_">Individual Radiosensitivity Measured With Lymphocytes: Late Effects Are the Key Point: In Regard to Borgmann et al. (Int J Radiat Oncol Biol Phys 2008;71:256–264)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37639426" href="https://independent.academia.edu/EkkehardDikomey">Ekkehard Dikomey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Radiation Oncology*Biology*Physics, 2009</p><p class="ds-related-work--abstract ds2-5-body-sm">PURPOSE: We tested whether the chromosomal radiosensitivity of in vitro irradiated lymphocytes could be used to predict the risk of acute reactions after radiotherapy. METHODS AND MATERIALS: Two prospective studies were performed: study A with 51 patients included ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Individual Radiosensitivity Measured With Lymphocytes: Late Effects Are the Key Point: In Regard to Borgmann et al. (Int J Radiat Oncol Biol Phys 2008;71:256–264)","attachmentId":42234680,"attachmentType":"pdf","work_url":"https://www.academia.edu/17735206/Individual_Radiosensitivity_Measured_With_Lymphocytes_Late_Effects_Are_the_Key_Point_In_Regard_to_Borgmann_et_al_Int_J_Radiat_Oncol_Biol_Phys_2008_71_256_264_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17735206/Individual_Radiosensitivity_Measured_With_Lymphocytes_Late_Effects_Are_the_Key_Point_In_Regard_to_Borgmann_et_al_Int_J_Radiat_Oncol_Biol_Phys_2008_71_256_264_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="17735209" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/17735209/Why_recent_studies_relating_normal_tissue_response_to_individual_radiosensitivity_might_have_failed_and_how_new_studies_should_be_performed">Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37639426" href="https://independent.academia.edu/EkkehardDikomey">Ekkehard Dikomey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Radiation Oncology*Biology*Physics, 2003</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Why recent studies relating normal tissue response to individual radiosensitivity might have failed and how new studies should be performed","attachmentId":39681108,"attachmentType":"pdf","work_url":"https://www.academia.edu/17735209/Why_recent_studies_relating_normal_tissue_response_to_individual_radiosensitivity_might_have_failed_and_how_new_studies_should_be_performed","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/17735209/Why_recent_studies_relating_normal_tissue_response_to_individual_radiosensitivity_might_have_failed_and_how_new_studies_should_be_performed"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="14020818" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14020818/Individualisation_of_radiotherapy_in_breast_cancer_patients_possible_usefulness_of_a_DNA_damage_assay_to_measure_normal_cell_radiosensitivity">Individualisation of radiotherapy in breast cancer patients: possible usefulness of a DNA damage assay to measure normal cell radiosensitivity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33052065" href="https://ugr.academia.edu/EscarlataL%C3%B3pez">Escarlata López</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Radiotherapy and Oncology, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Individualisation of radiotherapy in breast cancer patients: possible usefulness of a DNA damage assay to measure normal cell radiosensitivity","attachmentId":44699451,"attachmentType":"pdf","work_url":"https://www.academia.edu/14020818/Individualisation_of_radiotherapy_in_breast_cancer_patients_possible_usefulness_of_a_DNA_damage_assay_to_measure_normal_cell_radiosensitivity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/14020818/Individualisation_of_radiotherapy_in_breast_cancer_patients_possible_usefulness_of_a_DNA_damage_assay_to_measure_normal_cell_radiosensitivity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="53905482" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/53905482/Towards_Clinical_Application_of_Patients_Radiosensitivity_Data">Towards Clinical Application of Patients Radiosensitivity Data</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34256911" href="https://independent.academia.edu/AnneVral">Anne Vral</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Radioprotection, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Towards Clinical Application of Patients Radiosensitivity Data","attachmentId":70526244,"attachmentType":"pdf","work_url":"https://www.academia.edu/53905482/Towards_Clinical_Application_of_Patients_Radiosensitivity_Data","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/53905482/Towards_Clinical_Application_of_Patients_Radiosensitivity_Data"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="20016922" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20016922/The_relationship_between_cellular_radiation_sensitivity_and_tissue_response_may_provide_the_basis_for_individualising_radiotherapy_schedules">The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40927928" href="https://uppsala.academia.edu/IngelaTuresson">Ingela Turesson</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1994</p><p class="ds-related-work--abstract ds2-5-body-sm">There is a wide variation in normal tissue reactions to radiotherapy and in many situations the severity of these reactions limits radiotherapy dose. Clinical fractionation studies carried out in Gothenburg have demonstrated that a large part of the spectrum of normal tissue reactions is due to differences in individual normal tissue sensitivity. If this variation in normal tissue reactions is due to differences in intrinsic cellular radiosensitivity, it should be possible to predict tissue response based on measurement of cellular sensitivity. Here we report the initial results of a study aimed at establishing whether a direct relationship exists between cellular radiosensitivity and tissue response. Ten fibroblasts strains, including four duplicates, were established from a group of patients in the Gothenburg fractionation trials who had received radiotherapy following mastectomy. Skin doses were measured and both acute and late skin changes were observed following radiotherapy. R...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The relationship between cellular radiation sensitivity and tissue response may provide the basis for individualising radiotherapy schedules","attachmentId":40958616,"attachmentType":"pdf","work_url":"https://www.academia.edu/20016922/The_relationship_between_cellular_radiation_sensitivity_and_tissue_response_may_provide_the_basis_for_individualising_radiotherapy_schedules","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/20016922/The_relationship_between_cellular_radiation_sensitivity_and_tissue_response_may_provide_the_basis_for_individualising_radiotherapy_schedules"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="59876517" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/59876517/Individual_Radiosensitivity_in_Oncological_Patients_Linking_Adverse_Normal_Tissue_Reactions_and_Genetic_Features">Individual Radiosensitivity in Oncological Patients: Linking Adverse Normal Tissue Reactions and Genetic Features</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="61071014" href="https://independent.academia.edu/GroffE">Elena Groff</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Frontiers in Oncology</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Individual Radiosensitivity in Oncological Patients: Linking Adverse Normal Tissue Reactions and Genetic Features","attachmentId":73574068,"attachmentType":"pdf","work_url":"https://www.academia.edu/59876517/Individual_Radiosensitivity_in_Oncological_Patients_Linking_Adverse_Normal_Tissue_Reactions_and_Genetic_Features","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/59876517/Individual_Radiosensitivity_in_Oncological_Patients_Linking_Adverse_Normal_Tissue_Reactions_and_Genetic_Features"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="62934998" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62934998/Normal_tissue_radiosensitivity_How_important_is_it">Normal tissue radiosensitivity — How important is it?</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39973590" href="https://independent.academia.edu/JanNyman">Jan Nyman</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Clinical Oncology, 1996</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Normal tissue radiosensitivity — How important is it?","attachmentId":75537707,"attachmentType":"pdf","work_url":"https://www.academia.edu/62934998/Normal_tissue_radiosensitivity_How_important_is_it","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/62934998/Normal_tissue_radiosensitivity_How_important_is_it"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="102093474" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/102093474/Intrinsic_radiosensitivity_of_normal_human_fibroblasts_and_lymphocytes_after_high_and_low_dose_rate_irradiation">Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="240858339" href="https://independent.academia.edu/DavidCalender">David Calender</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cancer research, 1992</p><p class="ds-related-work--abstract ds2-5-body-sm">The existence of heritable radiosensitivity syndromes and clinical observations in radiotherapy patients suggests that human cellular radiosensitivity differs among individuals. We report here an in vitro study of radiosensitivity in 30 fibroblast and 29 lymphocyte cultures obtained from cancer patients and controls. In 25 cases, both fibroblasts and lymphocytes were obtained from the same donors. Fibroblasts were cultured from skin biopsy samples, and peripheral T-cell lymphocytes were cultured from blood. Clonogenic survival assays were performed by using high- and low-dose-rate irradiation; lymphocytes were in G0 phase and fibroblasts in confluent plateau phase. Various end points were calculated and compared (i.e., surviving fraction at 2 Gy, initial slope of the survival curve, and doses resulting in 10 and 1% survival, respectively). Depending on the end point, the coefficient of variation of the survival parameters ranged from 31 to 68% for lymphocytes and 21 to 41% for fibro...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Intrinsic radiosensitivity of normal human fibroblasts and lymphocytes after high- and low-dose-rate irradiation","attachmentId":102449868,"attachmentType":"pdf","work_url":"https://www.academia.edu/102093474/Intrinsic_radiosensitivity_of_normal_human_fibroblasts_and_lymphocytes_after_high_and_low_dose_rate_irradiation","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/102093474/Intrinsic_radiosensitivity_of_normal_human_fibroblasts_and_lymphocytes_after_high_and_low_dose_rate_irradiation"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="63661790" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/63661790/Inherent_radiosensitivity_and_its_impact_on_breast_cancer_chemo_radiotherapy">Inherent radiosensitivity and its impact on breast cancer chemo-radiotherapy</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="66834837" href="https://modares.academia.edu/HMozdarani">Hossein Mozdarani</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2017</p><p class="ds-related-work--abstract ds2-5-body-sm">About 10% of apparently normal individuals are sensi ve to clastogenic effects of physico-chemical agents. More than 45% of breast cancer pa ents’ exhibit elevated radiosensi vity. Although the nature of inherent radiosensi vity is not fully understood, but insufficiency and impaired DNA repair mechanism might be prime cause of radiosensi vity. This is evident from gene cally affected individuals such as ataxia telangiectasia, severe combined immunodeficiency, Xeroderma pigmentasum, Fanconi anemia who show sensi vity to ionizing radia on, ultraviolet light and alkyla ng agents. All these gene c diseases are caused due to impaired DNA damage repair mechanism. Radia on therapy (RT) is a common and effec ve way of treatment in several types of malignant tumors. Some cancer pa ents suffer from side effects of RT such as radia on induced early or late adverse responses in normal ssues within weeks, months, or even years post irradia on, due to intrinsic radiosensi vity. The RT efficiency...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inherent radiosensitivity and its impact on breast cancer chemo-radiotherapy","attachmentId":76017067,"attachmentType":"pdf","work_url":"https://www.academia.edu/63661790/Inherent_radiosensitivity_and_its_impact_on_breast_cancer_chemo_radiotherapy","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/63661790/Inherent_radiosensitivity_and_its_impact_on_breast_cancer_chemo_radiotherapy"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="118304947" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/118304947/Assessment_of_Individual_Radiosensitivity_in_Breast_Cancer_Patients_Using_a_Combination_of_Biomolecular_Markers">Assessment of Individual Radiosensitivity in Breast Cancer Patients Using a Combination of Biomolecular Markers</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="108415368" href="https://komenskeho.academia.edu/MargitaPobijakova">Margita Pobijakova</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biomedicines</p><p class="ds-related-work--abstract ds2-5-body-sm">About 5% of patients undergoing radiotherapy (RT) develop RT-related side effects. To assess individual radiosensitivity, we collected peripheral blood from breast cancer patients before, during and after the RT, and γH2AX/53BP1 foci, apoptosis, chromosomal aberrations (CAs) and micronuclei (MN) were analyzed and correlated with the healthy tissue side effects assessed by the RTOG/EORTC criteria. The results showed a significantly higher level of γH2AX/53BP1 foci before the RT in radiosensitive (RS) patients in comparison to normal responding patients (NOR). Analysis of apoptosis did not reveal any correlation with side effects. CA and MN assays displayed an increase in genomic instability during and after RT and a higher frequency of MN in the lymphocytes of RS patients. We also studied time kinetics of γH2AX/53BP1 foci and apoptosis after in vitro irradiation of lymphocytes. Higher levels of primary 53BP1 and co-localizing γH2AX/53BP1 foci were detected in cells from RS patients a...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Assessment of Individual Radiosensitivity in Breast Cancer Patients Using a Combination of Biomolecular Markers","attachmentId":113963700,"attachmentType":"pdf","work_url":"https://www.academia.edu/118304947/Assessment_of_Individual_Radiosensitivity_in_Breast_Cancer_Patients_Using_a_Combination_of_Biomolecular_Markers","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/118304947/Assessment_of_Individual_Radiosensitivity_in_Breast_Cancer_Patients_Using_a_Combination_of_Biomolecular_Markers"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":46501147,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":46501147,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_46501147" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. 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