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data-tooltip="Physics and Society">physics.soc-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Populations and Evolution">q-bio.PE</span> </div> </div> <p class="title is-5 mathjax"> Infectious disease surveillance needs for the United States: lessons from COVID-19 </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/q-bio?searchtype=author&amp;query=Lipsitch%2C+M">Marc Lipsitch</a>, <a href="/search/q-bio?searchtype=author&amp;query=Bassett%2C+M+T">Mary T. Bassett</a>, <a href="/search/q-bio?searchtype=author&amp;query=Brownstein%2C+J+S">John S. Brownstein</a>, <a href="/search/q-bio?searchtype=author&amp;query=Elliott%2C+P">Paul Elliott</a>, <a href="/search/q-bio?searchtype=author&amp;query=Eyre%2C+D">David Eyre</a>, <a href="/search/q-bio?searchtype=author&amp;query=Grabowski%2C+M+K">M. Kate Grabowski</a>, <a href="/search/q-bio?searchtype=author&amp;query=Hay%2C+J+A">James A. Hay</a>, <a href="/search/q-bio?searchtype=author&amp;query=Johansson%2C+M">Michael Johansson</a>, <a href="/search/q-bio?searchtype=author&amp;query=Kissler%2C+S+M">Stephen M. Kissler</a>, <a href="/search/q-bio?searchtype=author&amp;query=Larremore%2C+D+B">Daniel B. Larremore</a>, <a href="/search/q-bio?searchtype=author&amp;query=Layden%2C+J">Jennifer Layden</a>, <a href="/search/q-bio?searchtype=author&amp;query=Lessler%2C+J">Justin Lessler</a>, <a href="/search/q-bio?searchtype=author&amp;query=Lynfield%2C+R">Ruth Lynfield</a>, <a href="/search/q-bio?searchtype=author&amp;query=MacCannell%2C+D">Duncan MacCannell</a>, <a href="/search/q-bio?searchtype=author&amp;query=Madoff%2C+L+C">Lawrence C. Madoff</a>, <a href="/search/q-bio?searchtype=author&amp;query=Metcalf%2C+C+J+E">C. Jessica E. Metcalf</a>, <a href="/search/q-bio?searchtype=author&amp;query=Meyers%2C+L+A">Lauren A. Meyers</a>, <a href="/search/q-bio?searchtype=author&amp;query=Ofori%2C+S+K">Sylvia K. Ofori</a>, <a href="/search/q-bio?searchtype=author&amp;query=Quinn%2C+C">Celia Quinn</a>, <a href="/search/q-bio?searchtype=author&amp;query=Bento%2C+A+I+R">Ana I. Ramos Bento</a>, <a href="/search/q-bio?searchtype=author&amp;query=Reich%2C+N">Nick Reich</a>, <a href="/search/q-bio?searchtype=author&amp;query=Riley%2C+S">Steven Riley</a>, <a href="/search/q-bio?searchtype=author&amp;query=Rosenfeld%2C+R">Roni Rosenfeld</a>, <a href="/search/q-bio?searchtype=author&amp;query=Samore%2C+M+H">Matthew H. Samore</a>, <a href="/search/q-bio?searchtype=author&amp;query=Sampath%2C+R">Rangarajan Sampath</a> , et al. (5 additional authors not shown) </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="2311.13724v1-abstract-short" style="display: inline;"> The COVID-19 pandemic has highlighted the need to upgrade systems for infectious disease surveillance and forecasting and modeling of the spread of infection, both of which inform evidence-based public health guidance and policies. Here, we discuss requirements for an effective surveillance system to support decision making during a pandemic, drawing on the lessons of COVID-19 in the U.S., while l&hellip; <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2311.13724v1-abstract-full').style.display = 'inline'; document.getElementById('2311.13724v1-abstract-short').style.display = 'none';">&#9661; More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="2311.13724v1-abstract-full" style="display: none;"> The COVID-19 pandemic has highlighted the need to upgrade systems for infectious disease surveillance and forecasting and modeling of the spread of infection, both of which inform evidence-based public health guidance and policies. Here, we discuss requirements for an effective surveillance system to support decision making during a pandemic, drawing on the lessons of COVID-19 in the U.S., while looking to jurisdictions in the U.S. and beyond to learn lessons about the value of specific data types. In this report, we define the range of decisions for which surveillance data are required, the data elements needed to inform these decisions and to calibrate inputs and outputs of transmission-dynamic models, and the types of data needed to inform decisions by state, territorial, local, and tribal health authorities. We define actions needed to ensure that such data will be available and consider the contribution of such efforts to improving health equity. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2311.13724v1-abstract-full').style.display = 'none'; document.getElementById('2311.13724v1-abstract-short').style.display = 'inline';">&#9651; Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 22 November, 2023; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> November 2023. </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1403.0638">arXiv:1403.0638</a> <span>&nbsp;[<a href="https://arxiv.org/pdf/1403.0638">pdf</a>, <a href="https://arxiv.org/ps/1403.0638">ps</a>, <a href="https://arxiv.org/format/1403.0638">other</a>]&nbsp;</span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Tissues and Organs">q-bio.TO</span> </div> </div> <p class="title is-5 mathjax"> Determination of personalized diabetes treatment plans using a two-delay model </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/q-bio?searchtype=author&amp;query=Kissler%2C+S+M">S. M. Kissler</a>, <a href="/search/q-bio?searchtype=author&amp;query=Cichowitz%2C+C">C. Cichowitz</a>, <a href="/search/q-bio?searchtype=author&amp;query=Sankaranarayanan%2C+S">S. Sankaranarayanan</a>, <a href="/search/q-bio?searchtype=author&amp;query=Bortz%2C+D+M">D. M. Bortz</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1403.0638v1-abstract-short" style="display: inline;"> Diabetes cases worldwide have risen steadily over the past decades, lending urgency to the search for more efficient, effective, and personalized ways to treat the disease. Current treatment strategies, however, may fail to maintain ultradian oscillations in blood glucose concentration, an important element of a healthy alimentary system. Building upon recent successes in mathematical modeling of&hellip; <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1403.0638v1-abstract-full').style.display = 'inline'; document.getElementById('1403.0638v1-abstract-short').style.display = 'none';">&#9661; More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1403.0638v1-abstract-full" style="display: none;"> Diabetes cases worldwide have risen steadily over the past decades, lending urgency to the search for more efficient, effective, and personalized ways to treat the disease. Current treatment strategies, however, may fail to maintain ultradian oscillations in blood glucose concentration, an important element of a healthy alimentary system. Building upon recent successes in mathematical modeling of the human glucose-insulin system, we show that both food intake and insulin therapy likely demand increasingly precise control over insulin sensitivity if oscillations at a healthy average glucose concentration are to be maintained. We then suggest guidelines and personalized treatment options for diabetic patients that maintain these oscillations. We show that for a type II diabetic, both blood glucose levels can be controlled and healthy oscillations maintained when the patient gets an hour of daily exercise and is placed on a combination of Metformin and sulfonylurea drugs. We note that insulin therapy and an additional hour of exercise will reduce the patient&#39;s need for sulfonylureas. Results of a modeling analysis suggest that a typical type I diabetic&#39;s blood glucose levels can be properly controlled with a constant insulin infusion between 0.45 and 0.7 microU/(ml*min). Lastly, we note that all suggested strategies rely on existing clinical techniques and established treatment measures, and so could potentially be of immediate use in the design of an artificial pancreas. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1403.0638v1-abstract-full').style.display = 'none'; document.getElementById('1403.0638v1-abstract-short').style.display = 'inline';">&#9651; Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 3 March, 2014; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> March 2014. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">19 pages, 15 figures</span> </p> </li> </ol> <div class="is-hidden-tablet"> <!-- feedback for mobile only --> <span class="help" style="display: inline-block;"><a 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