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<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-VNS5L9E4H7"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-VNS5L9E4H7", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="Dr. Roth's interdisciplinary research focuses on the application of statistical machine learning to problems in high dimensional cancer biology. This research program encompasses the development of computational methods for studying clonal population structures and tumour evolution, as well as methodological work in computational statistics" /> <link rel="canonical" href="https://www.bccrc.ca/dept/mo/labs/roth-lab" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/mo/sites/molecularoncology/files/BCClogo_Research_MolecularOncology_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <link rel="icon" href="/dept/mo/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Roth Lab | Molecular Oncology</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_Bxn9zpdS07My99x7G76QyiQFY-SQtLPW6RDCCblqJIQ.css?delta=0&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/mo/sites/molecularoncology/files/css/css_b1Imd5Zfo6d9UtggtC_ak93-Ac2c67PnthKR5yWdzt8.css?delta=2&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> </head> <body class="colour--emerald not-front path--node page--lab"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--lab page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/dept/mo/">Molecular Oncology</a> </li> <li> <a href="/dept/mo/labs">Research Labs</a> </li> <li> Roth Lab </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Roth Lab</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--lab full"> <div class="node__inner"> <footer class="node"> <aside> <a href="/dept/mo/people/andrew-roth" class="button"><span>Dr. Andrew Roth, PhD </span> </a> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7556">604-675-8000 ext. 7556</a></div> <div class="field field--field_follow_links"> <div class="above field--label">Follow</div> <a href="https://scholar.google.co.uk/citations?hl=en&user=5hPCABoAAAAJ" target="_blank"><i class="fa fa-google"></i></a><a href="http://aroth85.github.io/" target="_blank"><i class="fa fa-google"></i></a> </div> </aside> </footer> <div class="node__main"> <div class="field field--body"><p>Dr. Roth's interdisciplinary research focuses on the application of statistical machine learning to problems in high dimensional cancer biology. This research program encompasses the development of computational methods for studying clonal population structures and tumour evolution, as well as methodological work in computational statistics</p></div> </div> </div> </article> <section id="people" class="layout layout__grid"><h2 class="section__title">Members</h2><h3 class="subsection__title">Faculty/Leaders</h3><div class="flexgrid"><article class="node node--profile teaser"> <a class="picture" href="/dept/mo/people/andrew-roth" ><figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/Andrew%20Roth.jpg?itok=-ITfQ9_O" width="580" height="460" alt="" /> </figure></a> <section> <h3 class="node__title"> <a href="/dept/mo/people/andrew-roth" rel="bookmark">Dr. Andrew Roth, PhD </a> </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Scientist </div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604-675-8000ext.7556">604-675-8000 ext. 7556</a></div> <a href= "https://www.bccrc.ca/dept/mo/contact/97" class="more">Send message</a> <a href="/dept/mo/people/andrew-roth" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> </div><h3 class="subsection__title">Staff</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-10/Cynthia%20Ferguson.jpg?itok=YklNRbtT" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Cynthia Ferguson </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Projects and Operations Leader </div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/mo/contact/155" class="more">Send message</a> </div> </section> </article> </div><h3 class="subsection__title">Students/Trainees</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Katherine Breen </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2021-01/MO_KevinChern_0.jpg?itok=MWl1SNBa" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Kevin Chern </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Anne-Sophie Fratzscher </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Yuxiang (Felix) Fu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Summer Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Emilia Hurtado </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Eric Lee </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Matteo Lepur </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Ji Won (Anna) Song </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2022-06/Jenkin%20Tsiu.jpg?itok=SD1bZ5fN" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Jenkin Tsui </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/mo/sites/molecularoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Shaocheng Wu </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> </div></section> <section id="careers" class="layout layout__expanding layout__careers"><h2 class="section__title">Open Positions</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node node--career expander"> <h2 class="node__title"> <a href="/dept/mo/careers/postdoctoral-fellow-computational-biology" rel="bookmark"><span>Postdoctoral Fellow, Computational Biology</span> </a> </h2> <div class="field field--field_lab"> <div class="field field--item field--field_lab"><a href="/dept/mo/labs/roth-lab" hreflang="en">Roth Lab</a></div> </div> <button class="icon" data-expand="">+</button> <div class="expanding"> <div class="field field--body"> <p>We are currently looking for a Postdoctoral Fellow to join Dr. Andrew Roth’s and Dr. Adi Steif’s computational cancer genomics research groups at the BC Cancer Research Institute (BCCRI).</p> <p>The current position is for a candidate with experience developing and applying computational methods to analyze high throughput biological data. The successful applicant will be part of an exceptional multidisciplinary team developing and applying single cell multiomic methods to study evolution and disease transformation risk in follicular lymphoma (FL). Funded by a multi-year Terry Fox New Frontiers Program Project Grant, the project is a close collaboration with clinicians, molecular biologists and bioinformatic scientists. The candidate will have the opportunity to work with a unique and complex dataset which includes single cell DNA, RNA and epigenetic data.</p> <p>This is an opportunity to work with highly motivated colleagues in a creative and dynamic environment. By joining the Roth and Steif labs at the BCCRI, you will develop close relationships with world-renown specialists in genomics and bioinformatics and have access to robust computational and sequencing technology facilities, all while living in one of the most beautiful, diverse and eclectic cities in the world.</p> <p>We offer a competitive salary, excellent benefits and significant career development opportunities</p> <p><strong>What you’ll do</strong></p> <p>Working in a multidisciplinary team, the postdoctoral fellow will develop and apply scalable analytical workflows for multiomic data integration and biological interpretation. The appointment is for one year in the first instance, with potential for renewal. Responsibilities include:</p> <ul> <li>Regularly review the scientific literature</li> <li>Contribute to experimental design and planning</li> <li>Data preprocessing and quality control</li> <li>Data analysis, visualization, and biological interpretation</li> <li>Develop and maintain well-documented code</li> <li>Regularly update Drs. Roth and Steif as well as key collaborators on the status of projects</li> <li>Participate in and present research updates at lab meetings, team meetings and conferences</li> <li>Contribute to scientific writing, including the preparation of research manuscripts and grant applications</li> <li>May be involved in recruitment, management, and supervision of trainees</li> </ul> <p><strong>What you bring</strong></p> <ul> <li>A PhD in bioinformatics, computer science, statistics or related discipline</li> <li>At least 2 years of research experience in bioinformatics, with a record of first-author publication</li> <li>Experience in genomics and high-throughput sequencing data analysis</li> <li>Experience in cancer research is an asset</li> <li>Programming fluency in Python or R</li> <li>Experience working in a Unix/Linux computing environment</li> </ul> <p>You have:</p> <ul> <li>Critical thinking and attention to detail</li> <li>Excellent verbal, written and interpersonal communication skills</li> <li>Ability to work independently and in a collaborative interdisciplinary team</li> <li>A strong work ethic, with demonstrated ability to manage time and prioritize to meet deadlines</li> <li>Commitment to upholding the shared responsibility of creating lasting and meaningful reconciliation in Canada as per TRC (2015) and BC's Declaration on the Rights of Indigenous Peoples Act (2019).</li> <li>Knowledge of social, economic, political and historical realities impacting indigenous communities and familiarity with Indigenous Cultural Safety and anti-racism and accompanying reports (BC DRIPA, TRC, etc.).</li> </ul> <p><strong>What we bring</strong></p> <p>Every PHSA employee enables the best possible patient care for our patients and their families. Whether you are providing direct care, conducting research, or making it possible for others to do their work, you impact the lives of British Columbians today and in the future. That’s why we’re focused on your care too – offering health, wellness, development programs to support you – at work and at home.</p> <ul> <li>Join one of BC’s largest employers with province-wide programs, services and operations – offering vast opportunities for growth, development, and recognition programs that honour the commitment and contribution of all employees.</li> <li>Access to professional development opportunities through our in-house training programs, including +2,000 courses, such as our San’yas Indigenous Cultural Safety Training course, or Core Linx for Leadership roles.</li> <li>PHSA is a remote work friendly employer, welcoming flexible work options to support our people (eligibility may vary, depending on position).</li> <li>Access to WorkPerks, a premium discount program offering a wide range of local and national discounts on electronics, entertainment, dining, travel, wellness, apparel, and more.</li> </ul> <p><strong>Job Type: Temporary, Casual <br> Location: 675 West 10th Avenue, Vancouver BC, V5Z 1G1<br> Hours of Work: Monday to Friday; 0830-1630</strong><br>  </p> <p><strong>As per the current Public Health Order, full vaccination against COVID-19 is a condition of employment with PHSA as of October 26, 2021.</strong></p> <p><strong> </strong></p> <p><strong>How to Apply</strong></p> <p>Applicants should submit: a CV; a one-page cover letter explaining how your research experience, interests and career goals align with the position; and the names and contact details of 3 references. </p> <p>While we value and review all applications, please note that due to the volume of submissions only shortlisted candidates will be contacted. This posting will remain online until the position is filled.</p> <p>All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.</p> <p><strong> </strong></p> <p><strong>What we do</strong></p> <p><strong>About the GSC:</strong></p> <p><a href="https://www.bcgsc.ca/">Canada’s Michael Smith Genome Sciences Centre (GSC)</a></p> <p><br> <a href="https://www.bcgsc.ca/about-us">Today’s Research. Tomorrow’s Medicine.</a></p> <p>The Genome Sciences Centre (GSC) is a department of the <a href="https://www.bccrc.ca/">BC Cancer Research Institute</a> and a high-throughput genome sequencing facility. We are <a href="https://www.bcgsc.ca/people/faculty">leaders</a> in genomics and bioinformatics pursuing novel treatment strategies for cancer and other diseases.</p> <p>Among the world’s first genome centres to be established within a cancer clinic, for <a href="https://www.bcgsc.ca/about-us/our-story">more than two decades</a> our scientists and innovators have been designing and deploying cutting-edge technologies to benefit health and advance clinical research.</p> <p>Among the GSC’s most significant accomplishments are the first <a href="https://genomebiology.biomedcentral.com/articles/10.1186/gb-2010-11-8-r82">publication</a> to demonstrate the use of whole-genome sequencing to inform cancer treatment planning, the first <a href="https://science.sciencemag.org/content/300/5624/1399.long">published</a> sequence of the SARS coronavirus genome and major contributions to the first <a href="https://www.nature.com/articles/35057157">physical map of the human genome</a> as part of the Human Genome Project.</p> <p>By joining the GSC you will become part of an exceptional and diverse <a href="https://www.bcgsc.ca/people">team</a> of scientists, clinicians, experts and professionals operating at the leading edge of clinical research.</p> <p>The GSC is part of BC Cancer Research Institute and the Provincial Health Services Authority (PHSA).</p> <p><a href="http://www.bccancer.bc.ca/">BC Cancer</a> provides comprehensive cancer control for the people of British Columbia.</p> <p><a href="http://www.bccancer.bc.ca/">BC Cancer</a> is part of the Provincial Health Services Authority (PHSA).</p> <p>(<a href="http://www.phsa.ca/">PHSA</a>) plans, manages and evaluates specialized health services with the BC health authorities to provide equitable and cost-effective health care for people throughout the province. Our values reflect our commitment to excellence and include: Respect people – Be compassionate – Dare to innovate – Cultivate partnerships – Serve with purpose.</p> <p>Learn more about PHSA and our programs: <a href="https://jobs.phsa.ca/programs-and-services">jobs.phsa.ca/programs-and-services</a></p> <p>PHSA is committed to employment equity, encouraging all qualified individuals to apply. We recognize that our ability to provide the best care for our diverse patient populations relies on a rich diversity of skills, knowledge, background and experience, and value a safe, inclusive and welcoming environment.</p> <p>Reconciliation is an ongoing process and a shared responsibility for all of us. The BC Governments’ unanimous passage of the Declaration on the Rights of Indigenous Peoples Act was a significant step forward in this journey—one that all health authorities are expected to support as we work in cooperation with Indigenous Peoples to establish a clear and sustainable path to lasting reconciliation. True reconciliation will take time and ongoing commitment to work with Indigenous Peoples as they move toward self-determination. Guiding these efforts Crown agencies must remain focused on creating opportunities that implement the Truth and Reconciliation Commission Mandate.</p></div> <div class="field field--field_application_link"><a href="https://jobs.phsa.ca/job/vancouver/postdoctoral-fellow-computational-biology-roth-lab-and-steif-lab-bc-cancer-vancouver/909/44633374032">Apply online now</a></div> </div> </article> </div></section> <section id="publications" class="layout layout__expanding layout__publications"><h2 class="section__title">Selected Publications</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28750660" target="_blank" rel="bookmark">ReMixT: clone-specific genomic structure estimation in cancer.</a> </h2> <div class="field field--field_journal">Genome biology, 2017</div> <div class="field field--field_authors">McPherson, Andrew W, Roth, Andrew, Ha, Gavin, Chauve, Cedric, Steif, Adi, de Souza, Camila P E, Eirew, Peter, Bouchard-Côté, Alexandre, Aparicio, Sam, Sahinalp, S Cenk, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28750660" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28557980" target="_blank" rel="bookmark">E-scape: interactive visualization of single-cell phylogenetics and cancer evolution.</a> </h2> <div class="field field--field_journal">Nature methods, 2017</div> <div class="field field--field_authors">Smith, Maia A, Nielsen, Cydney B, Chan, Fong Chun, McPherson, Andrew, Roth, Andrew, Farahani, Hossein, Machev, Daniel, Steif, Adi, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28557980" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/28249593" target="_blank" rel="bookmark">ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data.</a> </h2> <div class="field field--field_journal">Genome biology, 2017</div> <div class="field field--field_authors">Salehi, Sohrab, Steif, Adi, Roth, Andrew, Aparicio, Samuel, Bouchard-Côté, Alexandre, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/28249593" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/27183439" target="_blank" rel="bookmark">Clonal genotype and population structure inference from single-cell tumor sequencing.</a> </h2> <div class="field field--field_journal">Nature methods, 2016</div> <div class="field field--field_authors">Roth, Andrew, McPherson, Andrew, Laks, Emma, Biele, Justina, Yap, Damian, Wan, Adrian, Smith, Maia A, Nielsen, Cydney B, McAlpine, Jessica N, Aparicio, Samuel, Bouchard-Côté, Alexandre, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27183439" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/27182968" target="_blank" rel="bookmark">Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.</a> </h2> <div class="field field--field_journal">Nature genetics, 2016</div> <div class="field field--field_authors">McPherson, Andrew, Roth, Andrew, Laks, Emma, Masud, Tehmina, Bashashati, Ali, Zhang, Allen W, Ha, Gavin, Biele, Justina, Yap, Damian, Wan, Adrian, Prentice, Leah M, Khattra, Jaswinder, Smith, Maia A, Nielsen, Cydney B, Mullaly, Sarah C, Kalloger, Steve, Karnezis, Anthony, Shumansky, Karey, Siu, Celia, Rosner, Jamie, Chan, Hector Li, Ho, Julie, Melnyk, Nataliya, Senz, Janine, Yang, Winnie, Moore, Richard, Mungall, Andrew J, Marra, Marco A, Bouchard-Côté, Alexandre, Gilks, C Blake, Huntsman, David G, McAlpine, Jessica N, Aparicio, Samuel, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/27182968" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/26760213" target="_blank" rel="bookmark">Divergent clonal selection dominates medulloblastoma at recurrence.</a> </h2> <div class="field field--field_journal">Nature, 2016</div> <div class="field field--field_authors">Morrissy, A Sorana, Garzia, Livia, Shih, David J H, Zuyderduyn, Scott, Huang, Xi, Skowron, Patryk, Remke, Marc, Cavalli, Florence M G, Ramaswamy, Vijay, Lindsay, Patricia E, Jelveh, Salomeh, Donovan, Laura K, Wang, Xin, Luu, Betty, Zayne, Kory, Li, Yisu, Mayoh, Chelsea, Thiessen, Nina, Mercier, Eloi, Mungall, Karen L, Ma, Yusanne, Tse, Kane, Zeng, Thomas, Shumansky, Karey, Roth, Andrew J L, Shah, Sohrab, Farooq, Hamza, Kijima, Noriyuki, Holgado, Borja L, Lee, John J Y, Matan-Lithwick, Stuart, Liu, Jessica, Mack, Stephen C, Manno, Alex, Michealraj, K A, Nor, Carolina, Peacock, John, Qin, Lei, Reimand, Juri, Rolider, Adi, Thompson, Yuan Y, Wu, Xiaochong, Pugh, Trevor, Ally, Adrian, Bilenky, Mikhail, Butterfield, Yaron S N, Carlsen, Rebecca, Cheng, Young, Chuah, Eric, Corbett, Richard D, Dhalla, Noreen, He, An, Lee, Darlene, Li, Haiyan I, Long, William, Mayo, Michael, Plettner, Patrick, Qian, Jenny Q, Schein, Jacqueline E, Tam, Angela, Wong, Tina, Birol, Inanc, Zhao, Yongjun, Faria, Claudia C, Pimentel, José, Nunes, Sofia, Shalaby, Tarek, Grotzer, Michael, Pollack, Ian F, Hamilton, Ronald L, Li, Xiao-Nan, Bendel, Anne E, Fults, Daniel W, Walter, Andrew W, Kumabe, Toshihiro, Tominaga, Teiji, Collins, V Peter, Cho, Yoon-Jae, Hoffman, Caitlin, Lyden, David, Wisoff, Jeffrey H, Garvin, James H, Stearns, Duncan S, Massimi, Luca, Schüller, Ulrich, Sterba, Jaroslav, Zitterbart, Karel, Puget, Stephanie, Ayrault, Olivier, Dunn, Sandra E, Tirapelli, Daniela P C, Carlotti, Carlos G, Wheeler, Helen, Hallahan, Andrew R, Ingram, Wendy, MacDonald, Tobey J, Olson, Jeffrey J, Van Meir, Erwin G, Lee, Ji-Yeoun, Wang, Kyu-Chang, Kim, Seung-Ki, Cho, Byung-Kyu, Pietsch, Torsten, Fleischhack, Gudrun, Tippelt, Stephan, Ra, Young Shin, Bailey, Simon, Lindsey, Janet C, Clifford, Steven C, Eberhart, Charles G, Cooper, Michael K, Packer, Roger J, Massimino, Maura, Garre, Maria Luisa, Bartels, Ute, Tabori, Uri, Hawkins, Cynthia E, Dirks, Peter, Bouffet, Eric, Rutka, James T, Wechsler-Reya, Robert J, Weiss, William A, Collier, Lara S, Dupuy, Adam J, Korshunov, Andrey, Jones, David T W, Kool, Marcel, Northcott, Paul A, Pfister, Stefan M, Largaespada, David A, Mungall, Andrew J, Moore, Richard A, Jabado, Nada, Bader, Gary D, Jones, Steven J M, Malkin, David, Marra, Marco A, Taylor, Michael D</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/26760213" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/25470049" target="_blank" rel="bookmark">Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.</a> </h2> <div class="field field--field_journal">Nature, 2015</div> <div class="field field--field_authors">Eirew, Peter, Steif, Adi, Khattra, Jaswinder, Ha, Gavin, Yap, Damian, Farahani, Hossein, Gelmon, Karen, Chia, Stephen, Mar, Colin, Wan, Adrian, Laks, Emma, Biele, Justina, Shumansky, Karey, Rosner, Jamie, McPherson, Andrew, Nielsen, Cydney, Roth, Andrew J L, Lefebvre, Calvin, Bashashati, Ali, de Souza, Camila, Siu, Celia, Aniba, Radhouane, Brimhall, Jazmine, Oloumi, Arusha, Osako, Tomo, Bruna, Alejandra, Sandoval, Jose L, Algara, Teresa, Greenwood, Wendy, Leung, Kaston, Cheng, Hongwei, Xue, Hui, Wang, Yuzhuo, Lin, Dong, Mungall, Andrew J, Moore, Richard, Zhao, Yongjun, Lorette, Julie, Nguyen, Long, Huntsman, David, Eaves, Connie J, Hansen, Carl, Marra, Marco A, Caldas, Carlos, Shah, Sohrab P, Aparicio, Samuel</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/25470049" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/25060187" target="_blank" rel="bookmark">TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.</a> </h2> <div class="field field--field_journal">Genome research, 2014</div> <div class="field field--field_authors">Ha, Gavin, Roth, Andrew, Khattra, Jaswinder, Ho, Julie, Yap, Damian, Prentice, Leah M, Melnyk, Nataliya, McPherson, Andrew, Bashashati, Ali, Laks, Emma, Biele, Justina, Ding, Jiarui, Le, Alan, Rosner, Jamie, Shumansky, Karey, Marra, Marco A, Gilks, C Blake, Huntsman, David G, McAlpine, Jessica N, Aparicio, Samuel, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/25060187" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/24633410" target="_blank" rel="bookmark">PyClone: statistical inference of clonal population structure in cancer.</a> </h2> <div class="field field--field_journal">Nature methods, 2014</div> <div class="field field--field_authors">Roth, Andrew, Khattra, Jaswinder, Yap, Damian, Wan, Adrian, Laks, Emma, Biele, Justina, Ha, Gavin, Aparicio, Samuel, Bouchard-Côté, Alexandre, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/24633410" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/23780408" target="_blank" rel="bookmark">Distinct evolutionary trajectories of primary high-grade serous ovarian cancers revealed through spatial mutational profiling.</a> </h2> <div class="field field--field_journal">The Journal of pathology, 2013</div> <div class="field field--field_authors">Bashashati, Ali, Ha, Gavin, Tone, Alicia, Ding, Jiarui, Prentice, Leah M, Roth, Andrew, Rosner, Jamie, Shumansky, Karey, Kalloger, Steve, Senz, Janine, Yang, Winnie, McConechy, Melissa, Melnyk, Nataliya, Anglesio, Michael, Luk, Margaret T Y, Tse, Kane, Zeng, Thomas, Moore, Richard, Zhao, Yongjun, Marra, Marco A, Gilks, Blake, Yip, Stephen, Huntsman, David G, McAlpine, Jessica N, Shah, Sohrab P</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/23780408" target="_blank">Learn More</a></div> </article> </div></section> <section class="has-logos layout layout__sponsors"> <h2 class="section__title">Sponsors</h2> <div 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