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The extracts were subjected to a" /> <meta property="article:author" content="https://independent.academia.edu/GRexinThusnavis" /> <meta name="description" content="In the present study, phytochemical constituents of medicinal plants were evaluated from their ethanolic extracts, such as Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum. The extracts were subjected to a" /> <title>(PDF) An Evaluation of the Phytochemical Properties and Anticancer Activity of Selected Native Medicinal Plants</title> <link rel="canonical" href="https://www.academia.edu/92439597/An_Evaluation_of_the_Phytochemical_Properties_and_Anticancer_Activity_of_Selected_Native_Medicinal_Plants" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'bbdb80613189ba697977787ab78246749f444764'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1740478499000); window.Aedu.timeDifference = new Date().getTime() - 1740478499000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":"In the present study, phytochemical constituents of medicinal plants were evaluated from their ethanolic extracts, such as Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum. The extracts were subjected to a qualitative phytochemical screening using a standard procedure. Our study has identified phytocompounds present in leaf extracts of Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum using IR and GC-MS spectroscopy. An anticancer activity was performed on each of these extracts using two human cancer cell lines, a colon cancer cell line (HCT116) and a cervical cancer cell line (HeLa). Despite the four medicinal plants extracts having comparable anticancer activity, the ethanolic extracts of Andrographis paniculata and Solanum trilobatum show higher anticancer activity than Centella asiatica and Psidium guajava. The Andrographis paniculata (IC50=27.54 μg/ml HeLa and 30.19 μg/ml HCT116) and Solanum trilobatum (IC50=32...","author":[{"@context":"https://schema.org","@type":"Person","name":"G. Rexin Thusnavis","url":"https://independent.academia.edu/GRexinThusnavis"}],"contributor":[],"dateCreated":"2022-12-08","dateModified":"2023-03-29","headline":"An Evaluation of the Phytochemical Properties and Anticancer Activity of Selected Native Medicinal Plants","image":"https://attachments.academia-assets.com/95447574/thumbnails/1.jpg","inLanguage":"en","keywords":["Chemistry","Traditional Medicine","Phytochemical","Psidium","Andrographis paniculata","HeLa","Centella"],"publication":"Journal of Advanced Scientific Research","publisher":{"@context":"https://schema.org","@type":"Organization","name":"ScienSage"},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://attachments.academia-assets.com/95447574/thumbnails/1.jpg","url":"https://www.academia.edu/92439597/An_Evaluation_of_the_Phytochemical_Properties_and_Anticancer_Activity_of_Selected_Native_Medicinal_Plants"}</script><style 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window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":92439597,"created_at":"2022-12-08T09:46:16.548-08:00","from_world_paper_id":222294606,"updated_at":"2023-10-05T15:19:08.046-07:00","_data":{"abstract":"In the present study, phytochemical constituents of medicinal plants were evaluated from their ethanolic extracts, such as Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum. The extracts were subjected to a qualitative phytochemical screening using a standard procedure. Our study has identified phytocompounds present in leaf extracts of Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum using IR and GC-MS spectroscopy. An anticancer activity was performed on each of these extracts using two human cancer cell lines, a colon cancer cell line (HCT116) and a cervical cancer cell line (HeLa). Despite the four medicinal plants extracts having comparable anticancer activity, the ethanolic extracts of Andrographis paniculata and Solanum trilobatum show higher anticancer activity than Centella asiatica and Psidium guajava. The Andrographis paniculata (IC50=27.54 μg/ml HeLa and 30.19 μg/ml HCT116) and Solanum trilobatum (IC50=32...","publisher":"ScienSage","publication_name":"Journal of Advanced Scientific Research"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"An Evaluation of the Phytochemical Properties and Anticancer Activity of Selected Native Medicinal Plants","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [56166611]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon'; window.userInChina = "false";</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":95447574,"attachmentType":"pdf"}"><img alt="First page of “An Evaluation of the Phytochemical Properties and Anticancer Activity of Selected Native Medicinal Plants”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/95447574/mini_magick20221208-1-1cwapc.png?1670521615" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">An Evaluation of the Phytochemical Properties and Anticancer Activity of Selected Native Medicinal Plants</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="56166611" href="https://independent.academia.edu/GRexinThusnavis"><img alt="Profile image of G. Rexin Thusnavis" class="ds-work-card--author-avatar" src="https://0.academia-photos.com/56166611/17259533/17378978/s65_g._rexin.thusnavis.jpg" />G. Rexin Thusnavis</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">Journal of Advanced Scientific Research</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">10 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 92439597; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=92439597"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">In the present study, phytochemical constituents of medicinal plants were evaluated from their ethanolic extracts, such as Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum. The extracts were subjected to a qualitative phytochemical screening using a standard procedure. Our study has identified phytocompounds present in leaf extracts of Andrographis paniculata, Centella asiatica, Psidium guajava and Solanum trilobatum using IR and GC-MS spectroscopy. An anticancer activity was performed on each of these extracts using two human cancer cell lines, a colon cancer cell line (HCT116) and a cervical cancer cell line (HeLa). Despite the four medicinal plants extracts having comparable anticancer activity, the ethanolic extracts of Andrographis paniculata and Solanum trilobatum show higher anticancer activity than Centella asiatica and Psidium guajava. The Andrographis paniculata (IC50=27.54 μg/ml HeLa and 30.19 μg/ml HCT116) and Solanum trilobatum (IC50=32...</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":95447574,"attachmentType":"pdf","workUrl":"https://www.academia.edu/92439597/An_Evaluation_of_the_Phytochemical_Properties_and_Anticancer_Activity_of_Selected_Native_Medicinal_Plants"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":95447574,"attachmentType":"pdf","workUrl":"https://www.academia.edu/92439597/An_Evaluation_of_the_Phytochemical_Properties_and_Anticancer_Activity_of_Selected_Native_Medicinal_Plants"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger ds-signup-banner-trigger-control"></div></div><div class="ds-signup-banner ds-signup-banner-control"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free<span class="material-symbols-outlined" style="font-size: 20px" translate="no">arrow_forward</span></button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. 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Anticancerous activity of Andrographis paniculata, Nees., Centella asiatica, L. and Murraya koenigii,L. were studied.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"PHYTOCHEMICAL ANALYSIS AND ANTICANCEROUS ACTIVITY OF SELECTED MEDICINAL PLANTS ","attachmentId":38151357,"attachmentType":"pdf","work_url":"https://www.academia.edu/13886278/PHYTOCHEMICAL_ANALYSIS_AND_ANTICANCEROUS_ACTIVITY_OF_SELECTED_MEDICINAL_PLANTS","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13886278/PHYTOCHEMICAL_ANALYSIS_AND_ANTICANCEROUS_ACTIVITY_OF_SELECTED_MEDICINAL_PLANTS"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="37564932" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/37564932/Phytochemical_analysis_and_anticancer_screening_of_some_indigenous_plants_grown_in_Saudi_Arabia">Phytochemical analysis and anticancer screening of some indigenous plants grown in Saudi Arabia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="174532" href="https://tanta.academia.edu/ProfMohamedLabibSalem">Prof. Mohamed Labib Salem</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Phytochemical analysis and anticancer screening of some indigenous plants grown in Saudi Arabia","attachmentId":57542033,"attachmentType":"pdf","work_url":"https://www.academia.edu/37564932/Phytochemical_analysis_and_anticancer_screening_of_some_indigenous_plants_grown_in_Saudi_Arabia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/37564932/Phytochemical_analysis_and_anticancer_screening_of_some_indigenous_plants_grown_in_Saudi_Arabia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="100384271" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/100384271/Evaluation_of_some_plant_extracts_for_standardization_and_anticancer_activity">Evaluation of some plant extracts for standardization and anticancer activity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="128356583" href="https://independent.academia.edu/DrMMPadhi">Dr. M.M. Padhi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Indian journal of traditional knowledge</p><p class="ds-related-work--abstract ds2-5-body-sm">In recent times, the trend in cancer research is shifting towards identifying new medicines from natural resources for management of cancer. Medicinal plants such as Sthauneyaka (Taxus baccata L.) and compound formulations like Triphala ghrita, Khadirarista, Madhusnuhi rasayana, Maha triphaladya ghrita, Panchatikta guggulu ghrita are indicated in the Ayurvedic texts for management of cancer/ tumour. The anti-proliferative activities of hydro-alcoholic extracts of some standardized plant materials were screened against a panel of 14 human cancer cell lines representing different tissues (lung, pancreas, colon, cervix, oral, bladder, prostate, breast, leukaemia, etc.) through Sulforhodamine-B (SRB) assay. The findings revealed that Cedrus deodara (Roxb.) ex Lamb. and Berberis aristata (Roxb.) ex DC. have maximum anticancer activity against 3 cell lines while Withania somnifera Dunal. showed activity against two cell lines. In addition to these, Picrorhiza kurroa Royle ex Benth. and Pi...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evaluation of some plant extracts for standardization and anticancer activity","attachmentId":101223232,"attachmentType":"pdf","work_url":"https://www.academia.edu/100384271/Evaluation_of_some_plant_extracts_for_standardization_and_anticancer_activity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/100384271/Evaluation_of_some_plant_extracts_for_standardization_and_anticancer_activity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="95058594" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/95058594/Anticancer_activity_of_Medicinal_plant_extract_A_re_view">Anticancer activity of Medicinal plant extract-A re view</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="13713277" href="https://independent.academia.edu/SavitaDixit">Savita Dixit</a></div><p class="ds-related-work--metadata ds2-5-body-xs">2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Traditional medicine has a long history of serving peoples all over the world. India is without doubt a herbal hub. Medicin al plants that are native to India and their use in various traditiona l systems of medicine are indeed awe-inspiring. The ethnobotany and ubiquitous plants provide a rich resource for Natural drug research a nd development. In recent years, the use of traditional medicine infor mation on plant research received considerable interest. The medici nal plants contain several phytochemicals such as vitamins, carotenoid s, terpenoids, flavonoids, polyphenols, alkaloids, tannins, saponi ns, enzymes, minerals etc. These phytochemicals possess antioxid ant activities, which, prevent or can be used in the treatment of m any diseases, including cancer. There are the several medicinal p lants all over the world, including India, which are being used tradit ionally for the prevention and treatment of cancer. The present pap er is a comprehensive review of different literat...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Anticancer activity of Medicinal plant extract-A re view","attachmentId":97345401,"attachmentType":"pdf","work_url":"https://www.academia.edu/95058594/Anticancer_activity_of_Medicinal_plant_extract_A_re_view","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/95058594/Anticancer_activity_of_Medicinal_plant_extract_A_re_view"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="60843674" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/60843674/In_Vitro_Screening_of_Some_Plant_Extracts_for_Their_Potential_Anticancer_Activity">In-Vitro Screening of Some Plant Extracts for Their Potential Anticancer Activity</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20740129" href="https://boscobae.academia.edu/heshamhaffez">hesham haffez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">African Journal of Traditional, Complementary and Alternative Medicines</p><p class="ds-related-work--abstract ds2-5-body-sm">Background: Natural products have been shown to be reliable sources of anticancer medicines although there is still a consistent demand for new therapeutic natural products for cancer treatment with minimal side-effects. Materials and Methods: In this study, six plant extracts (Grevillea robusta; Euphorbia millii; Euphorbia royleana; Aloe grandidentata; Bauhinia corniculate; and Cassia fistula) were screened for the presence of phytochemical metabolites as saponins, tannins, cardiac glycosides, alkaloids, flavonoids, anthraquinones and sterols, using qualitative tests. Antiproliferative screening assay was performed on a panel of three cancer cell-lines (HepG-2, HCT-116 and MCF-7) using MTT assay, and cytotoxicity was determined using WI-38 human fibroblast cell-line. Results: Some plant extracts reduced cellular growth for the selected cancerous cell-lines. For example, E. royleana and A. grandidentata extracts reduced HepG-2 cellular growth with IC50 of 0.42 and 0.53µg/mL, respectively. Moreover, A. grandidentata and C. fistula reduced cellular growth of MCF-7 with IC50 of 0.37 and 0.67 µg/mL, respectively. Conclusion: E. royleana, A. grandidentata and C. fistula showed significant anti-proliferative activity against HepG-2 and MCF-7 cell-lines with non-cytotoxic nature. This suggests their potential role as anticancer agents against these types of cancer. The presence of flavonoids, sterols and anthraquinones may suggest their enhanced anti-proliferative activities. Therefore, this study has shed light on the possible use of these extracts as potential sources of natural products-based therapy for cancer.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"In-Vitro Screening of Some Plant Extracts for Their Potential Anticancer Activity","attachmentId":74111125,"attachmentType":"pdf","work_url":"https://www.academia.edu/60843674/In_Vitro_Screening_of_Some_Plant_Extracts_for_Their_Potential_Anticancer_Activity","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/60843674/In_Vitro_Screening_of_Some_Plant_Extracts_for_Their_Potential_Anticancer_Activity"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="103589363" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/103589363/Broad_spectrum_survey_of_medicinal_plants_as_a_potential_source_of_anticancer_agents">Broad-spectrum survey of medicinal plants as a potential source of anticancer agents</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="254402666" href="https://independent.academia.edu/KGopi8">K Gopi</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, 2022</p><p class="ds-related-work--abstract ds2-5-body-sm">Cancer is an abnormal and uncontrolled growth of cells that spreads through cell division. There are different types of medicines available to treat cancers, but no drug is found to be fully effective and safe for humans. The major problem involved in the cancer treatments is the toxicity of the established drug and their side effects. Medicinal plants are used as folk medicines in Asian and African populations for thousands of years. 60% of the drugs for treating cancer are derived from plants. More than 3000 plants have anticancer activity. The present review aims at the study of a broad spectrum survey of plants having anticancer components for different type of cancers. This article consists of 364 medicinal plants and their different parts as potential Source of Anticancer Agents.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Broad-spectrum survey of medicinal plants as a potential source of anticancer agents","attachmentId":103557008,"attachmentType":"pdf","work_url":"https://www.academia.edu/103589363/Broad_spectrum_survey_of_medicinal_plants_as_a_potential_source_of_anticancer_agents","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/103589363/Broad_spectrum_survey_of_medicinal_plants_as_a_potential_source_of_anticancer_agents"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="123775673" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/123775673/Phytochemical_Screening_and_in_vitro_Anticancer_Activity_of_Some_Medicinal_Plants_Grown_in_the_Kingdom_of_Saudi_Arabia">Phytochemical Screening and in vitro Anticancer Activity of Some Medicinal Plants Grown in the Kingdom of Saudi Arabia</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44681507" href="https://independent.academia.edu/UsamaMahalel">Usama Mahalel</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Morphology, 2024</p><p class="ds-related-work--abstract ds2-5-body-sm">This study evaluated the phytochemical screening, antioxidant capacity, and in vitro anticancer activities of four plants namely, Gypsophila capillaris, Anabasis lachnantha, Haloxylon salicornicum, and Horwoodia dicksoniae which belong to four different families: Caryophyllaceae, Amaranthaceae, Chenopodiaceae, Brassicaceae, respectively. The total phenolics, anthocyanins, saponins, total antioxidant capacity (TAC), and DPPH assays were determined by spectrophotometer. In vitro anticancer activity was assessed using two human cancer cell lines; hepatocellular carcinoma (HepG-2) and breast adenocarcinoma (MCF-7) to estimate the inhibition concentration 50 % (IC 50). The results showed that H. dicksoniae has the highest concentrations of phenolics and saponins, while H. salicornicum has the highest DPPH. The highest concentration of TAC was found in G. capillaries. Among the tested extracts, G. capillaries and H. salicornicum have the potential activity against MCF-7 and HepG-2 cell lines in vitro. The content of polyphenols in G. capillaries was profiled by high-performance liquid chromatography (HPLC). The highest concentration among the phenolic compounds was chlorogenic (60.8 µg/ml) while the highest concentration among the flavonoid compounds was hesperidin (1444.92 µg/ml). In summary, G. capillaries and H. salicornicum extracts have potent anticancer activity against HepG-2 and MCF-7 cell lines.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Phytochemical Screening and in vitro Anticancer Activity of Some Medicinal Plants Grown in the Kingdom of Saudi Arabia","attachmentId":118129040,"attachmentType":"pdf","work_url":"https://www.academia.edu/123775673/Phytochemical_Screening_and_in_vitro_Anticancer_Activity_of_Some_Medicinal_Plants_Grown_in_the_Kingdom_of_Saudi_Arabia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/123775673/Phytochemical_Screening_and_in_vitro_Anticancer_Activity_of_Some_Medicinal_Plants_Grown_in_the_Kingdom_of_Saudi_Arabia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="33680287" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33680287/A_Review_on_Medicinal_Plants_as_a_Potential_Source_for_Cancer_pdf">A Review on Medicinal Plants as a Potential Source for Cancer.pdf</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5240453" href="https://svuniversity.academia.edu/PulicherlaYugandhar">Pulicherla Yugandhar</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Cancer is a major health problem in both developed and developing countries. Cancer is the second leading cause of death after cardiovascular disease. Due to high death rate associated with cancer and serious side effects of chemotherapy and radiation therapy, many cancer patients seek alternative and/or complementary methods of treatment. India, which are being used traditionally for the prevention and treatment of cancer. However, only few medicinal plants have attracted the interest of scientists to investigate the remedy for neoplasm (tumor or cancer). Hence, an attempt has been made to review some medicinal plants used to prove scientific validation for the prevention and treatment of cancer. This article considers 82 medicinal plants belonging to 46 families and information on the Botanical name, family name, parts used, experimental model and mechanism of action were presented. This article provides basic handful information for researchers who are interested to work on medicinal plants for innovation of active biological compounds that to work on cancer as a principle mechanism.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A Review on Medicinal Plants as a Potential Source for Cancer.pdf","attachmentId":53685338,"attachmentType":"pdf","work_url":"https://www.academia.edu/33680287/A_Review_on_Medicinal_Plants_as_a_Potential_Source_for_Cancer_pdf","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33680287/A_Review_on_Medicinal_Plants_as_a_Potential_Source_for_Cancer_pdf"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="82358386" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/82358386/Anticancer_activity_of_plant_leaves_extract_collected_from_a_tribal_region_of_India">Anticancer activity of plant leaves extract collected from a tribal region of India</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5862152" href="https://independent.academia.edu/GouravSinha">Gourav Sinha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">3 Biotech, 2019</p><p class="ds-related-work--abstract ds2-5-body-sm">The goal of this research was to explore the preliminary anticancer properties of five plants namely Calotropis procera, Moringa oleifera, Millettia pinnata, Basela alba and Euphorbia neriifolia available in Jharkhand which is used for the medicinal purpose by local tribes. In the present study, plant leaves from five species were collected, dried and extracted with solvents of increasing polarity, followed by assessment of their cytotoxicity in A549 non-small-cell lung cancer cells. In the antimicrobial assay, the methanol extract of the M. pinnata leaves exhibited comparatively higher zone of inhibition of 0.7 ± 0.20 cm against a Salmonella typhi culture than the other extracts. M. pinnata leaves extract also displayed the maximum percentage inhibition in the DPPH, 83.97 ± 0.01 FRAP, 193.14 ± 3.01 mM assays. Furthermore, the cytotoxicity of the chloroform (37.45 ± 1.04) and ethyl acetate extracts (34.20 ± 0.81) of M. pinnata against A549 cells was found relatively higher with respect to another extract. In contrast, a study with the L132 normal epithelial lung cell line revealed less toxicity from the chloroform extract (0.33 ± 0.19) compared to the ethyl acetate extract (6.65 ± 0.59). Based on these findings, phytochemical investigation on chloroform and ethyl acetate extract of M. pinnata was performed using UPLC-ESI-MS/MS analysis revealing the presence of β-sitosterol, lanceolatin B, karanjin, and stigmasterol. Congruently, a complete phytochemical and cytotoxic investigation of the M. pinnata extract constituents might infer the potency of this extract/s as anticancer, antioxidant and antimicrobial agents.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Anticancer activity of plant leaves extract collected from a tribal region of India","attachmentId":88094459,"attachmentType":"pdf","work_url":"https://www.academia.edu/82358386/Anticancer_activity_of_plant_leaves_extract_collected_from_a_tribal_region_of_India","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/82358386/Anticancer_activity_of_plant_leaves_extract_collected_from_a_tribal_region_of_India"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":95447574,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":95447574,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_95447574" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="74317495" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/74317495/Anticancer_Activity_of_Five_Traditionally_Used_Medicinal_Plants_Extracts">Anticancer Activity of Five Traditionally Used Medicinal Plants’ Extracts</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="68048641" href="https://independent.academia.edu/amirhassan30">amir hassan</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Cancer Research Updates, 2014</p><div 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