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tissues, organs and types of cells. Prime Editors work broadly across almost all types of genetic mutations at the natural genomic location, while minimizing unwanted DNA modifications. The Prime Editing platform is designed to be able to produce a wide variety of precise, predictable and efficient genetic outcomes at the targeted pathogenic gene sequence, which we believe will dramatically increase the impact of gene editing for a broad range of therapeutic applications.</p> </div> </div> </div> </div> <div class="section section-padding video-panel dark" id="video-panel"> <div class="sub-section section-padding" style="background-color:#182fe9;"> <div class="container-fluid"> <div class="row"> <div class="col-md-5 dark"> <div class="content"> <p>Prime Medicine aims to deliver a new class of differentiated one-time curative genetic therapies to patients to address the widest spectrum of diseases. Watch how it is intended to work inside the human body to address an example of a disease caused by a single base mutation in a gene.</p> <ul class="video-menu"> <li><button id="video-1" class="active">Full video_</button></li> <li><button id="video-2" >How mutation causes disease_</button></li> <li><button id="video-3" >Delivery of Prime Editing therapy</button></li> <li><button id="video-4" >Prime Editing mechanism_</button></li> <li><button id="video-5" >How corrected mutation treats disease_</button></li> </ul> </div> </div> <div class="col-md-6 col-md-offset-1 hidden-lg"> <div class="content box-padding bg-gray video-btn-wrapper"> <div class="video-content video-1" > <a href="#video-modal-1" data-toggle="modal" data-target="#vimeo-modal-1" data-theVideo="https://player.vimeo.com/video/814737988"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-full-video.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-2" style="display:none;" > <a href="#video-modal-2" data-toggle="modal" data-target="#vimeo-modal-2" data-theVideo="https://player.vimeo.com/video/814759027"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch1.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-3" style="display:none;" > <a href="#video-modal-3" data-toggle="modal" data-target="#vimeo-modal-3" data-theVideo="https://player.vimeo.com/video/814767356"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch2.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-4" style="display:none;" > <a href="#video-modal-4" data-toggle="modal" data-target="#vimeo-modal-4" data-theVideo="https://player.vimeo.com/video/814770038"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch3.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-5" style="display:none;" > <a href="#video-modal-5" data-toggle="modal" data-target="#vimeo-modal-5" data-theVideo="https://player.vimeo.com/video/814782223"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch4.jpg" class="img-responsive" /> </a> </div> </div> </div> </div> </div> </div> <div class="sub-section visible-lg"> <div class="container-fluid"> <div class="row"> <div class="col-md-7 col-md-offset-5"> <div class="content box-padding bg-gray video-btn-wrapper"> <div class="video-content video-1" > <a href="#video-modal-1" data-toggle="modal" data-target="#vimeo-modal-1" data-theVideo="https://player.vimeo.com/video/814737988"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-full-video.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-2" style="display:none;"> <a href="#video-modal-2" data-toggle="modal" data-target="#vimeo-modal-2" data-theVideo="https://player.vimeo.com/video/814759027"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch1.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-3" style="display:none;"> <a href="#video-modal-3" data-toggle="modal" data-target="#vimeo-modal-3" data-theVideo="https://player.vimeo.com/video/814767356"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch2.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-4" style="display:none;"> <a href="#video-modal-4" data-toggle="modal" data-target="#vimeo-modal-4" data-theVideo="https://player.vimeo.com/video/814770038"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch3.jpg" class="img-responsive" /> </a> </div> <div class="video-content video-5" style="display:none;"> <a href="#video-modal-5" data-toggle="modal" data-target="#vimeo-modal-5" data-theVideo="https://player.vimeo.com/video/814782223"> <img src="https://primemedicine.com/wp-content/uploads/2023/04/prime-video-ch4.jpg" class="img-responsive" /> </a> </div> </div> </div> </div> </div> </div> </div> <div class="modal video-modal fade in" id="vimeo-modal-1" tabindex="-1" role="dialog" aria-labelledby="myModalLabel" style="padding-right: 17px;" aria-hidden="false"> <div class="ver-div"> <div class="modal-dialog modal-lg" role="document"> <div class="modal-content"> <div class="modal-header"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true"><i class="fal fa-window-close"></i></span></button> </div> <div class="modal-body"> <div style="padding:56.25% 0 0 0;position:relative;"><iframe src="" style="position:absolute;top:0;left:0;width:100%;height:100%;" frameborder="0" allow="autoplay; 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fullscreen; picture-in-picture" allowfullscreen></iframe></div><script src="https://player.vimeo.com/api/player.js"></script> </div> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="how-prime-editing-works" > <div class="container-fluid"> <h2 class="section-label">science</h2> <div class="row"> <div class="col-md-12 content"> <h2>How Prime Editing Works</h2> <h4><span style="color: #172fe9;">Programmable for both search and replace</span></h4> <div class="image-chart hover-blocks"> <div><img decoding="async" width="1082" height="1714" class="alignnone size-full wp-image-231" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Prime_step1_Graphic_062821_v1.jpg" alt="" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Prime_step1_Graphic_062821_v1.jpg 1082w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step1_Graphic_062821_v1-189x300.jpg 189w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step1_Graphic_062821_v1-646x1024.jpg 646w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step1_Graphic_062821_v1-768x1217.jpg 768w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step1_Graphic_062821_v1-970x1536.jpg 970w" sizes="(max-width: 1082px) 100vw, 1082px" /></div> <div><img decoding="async" width="1082" height="1714" class="alignnone size-full wp-image-228" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Prime_step-2_Graphic_062821_v1.jpg" alt="" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-2_Graphic_062821_v1.jpg 1082w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-2_Graphic_062821_v1-189x300.jpg 189w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-2_Graphic_062821_v1-646x1024.jpg 646w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-2_Graphic_062821_v1-768x1217.jpg 768w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-2_Graphic_062821_v1-970x1536.jpg 970w" sizes="(max-width: 1082px) 100vw, 1082px" /></div> <div><img decoding="async" width="1082" height="1714" class="alignnone size-full wp-image-229" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Prime_step-3_Graphic_070721.jpg" alt="" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-3_Graphic_070721.jpg 1082w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-3_Graphic_070721-189x300.jpg 189w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-3_Graphic_070721-646x1024.jpg 646w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-3_Graphic_070721-768x1217.jpg 768w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-3_Graphic_070721-970x1536.jpg 970w" sizes="(max-width: 1082px) 100vw, 1082px" /></div> <div><img decoding="async" width="1082" height="1714" class="alignnone size-full wp-image-230" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Prime_step-4_Graphic_062821_v1.jpg" alt="" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-4_Graphic_062821_v1.jpg 1082w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-4_Graphic_062821_v1-189x300.jpg 189w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-4_Graphic_062821_v1-646x1024.jpg 646w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-4_Graphic_062821_v1-768x1217.jpg 768w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_step-4_Graphic_062821_v1-970x1536.jpg 970w" sizes="(max-width: 1082px) 100vw, 1082px" /></div> <div><img decoding="async" width="1082" height="1714" class="alignnone size-full wp-image-227" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Prime_gene_Graphic_062821_v1.jpg" alt="" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Prime_gene_Graphic_062821_v1.jpg 1082w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_gene_Graphic_062821_v1-189x300.jpg 189w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_gene_Graphic_062821_v1-646x1024.jpg 646w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_gene_Graphic_062821_v1-768x1217.jpg 768w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_gene_Graphic_062821_v1-970x1536.jpg 970w" sizes="(max-width: 1082px) 100vw, 1082px" /></div> </div> <p class="footnote">Exemplary Prime Editing process using Cas and RT. Abbreviations: pegRNA = Prime Editing guide RNA; RT = reverse transcriptase; Cas = CRISPR associated protein</p> </div> </div> </div> </div> <div class="section section-padding science-copy-block dark" id="section-4" style="background-color:#381f9c;"> <div class="container-fluid"> <div class="row"> <div class="col-md-12 content"> <h4>Key Features</h4> <ul> <li>Programmable and highly flexible</li> <li>High fidelity and specificity</li> <li>High editing efficiency</li> <li>Minimal off-target activity</li> <li>Potential for improved gene function through <em>in situ</em> editing</li> <li>Edits in multiple clinically relevant dividing and non-dividing cell-types and organs </li> <li>No DNA double-strand breaks</li> <li>Validated in multiple independent laboratories worldwide</li> </ul> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="versatile" > <div class="container-fluid"> <h2 class="section-label">versatile</h2> <div class="row"> <div class="col-md-12 content"> <h2>Prime Editing can correct all different types of mutations</h2> <div class="row hover-blocks"> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">Point Mutation</p> <p style="text-align: center;">Convert <em>any</em> base pair into any other</p> <p><img decoding="async" class="alignnone size-full wp-image-235" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Group-7.png" alt="" width="498" height="456" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Group-7.png 498w, https://primemedicine.com/wp-content/uploads/2022/07/Group-7-300x275.png 300w" sizes="(max-width: 498px) 100vw, 498px" /></p> </div> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">Point Mutation</p> <p style="text-align: center;">Mutated base pairs can be substituted</p> <p><img decoding="async" class="alignnone size-full wp-image-232" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/base-pairs_Base-changed.png" alt="" width="917" height="834" srcset="https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Base-changed.png 917w, https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Base-changed-300x273.png 300w, https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Base-changed-768x698.png 768w" sizes="(max-width: 917px) 100vw, 917px" /></p> </div> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">Insertion Mutation</p> <p style="text-align: center;">Extra base pairs can be removed</p> <p><img decoding="async" class="alignnone size-full wp-image-233" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/base-pairs_Extra-sequence-removed.png" alt="" width="917" height="834" srcset="https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Extra-sequence-removed.png 917w, https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Extra-sequence-removed-300x273.png 300w, https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Extra-sequence-removed-768x698.png 768w" sizes="(max-width: 917px) 100vw, 917px" /></p> </div> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">Deletion Mutation</p> <p style="text-align: center;">Missing base pairs can be inserted</p> <p><img decoding="async" class="alignnone size-full wp-image-234" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/base-pairs_Missing-sequence-added.png" alt="" width="917" height="834" srcset="https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Missing-sequence-added.png 917w, https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Missing-sequence-added-300x273.png 300w, https://primemedicine.com/wp-content/uploads/2022/07/base-pairs_Missing-sequence-added-768x698.png 768w" sizes="(max-width: 917px) 100vw, 917px" /></p> </div> </div> </div> </div> </div> </div> <div class="section section-padding science-copy-block dark" id="section-6" style="background-color:#0b1775;"> <div class="container-fluid"> <div class="row"> <div class="col-md-12 content"> <h4>Versatile</h4> <p>Prime Editing can make diverse sequence edits at nearly any desired location in the human genome, enabling multiple therapeutic applications. Prime Editors are able to change any base pair to any other base pair to correct all twelve types of single base pair point mutations, delete DNA sequences to correct insertion mutations, and insert DNA sequences to correct deletion mutations. Prime Editors also have the ability to correct genetic mutation hotspots and modify or silence gene expression by altering the regulatory regions of genes, inserting or creating premature stop codons, or modifying splicing sequences. Prime Editors additionally have the capacity to install genetic sequences to protect from disease or to correct genetic variants that increase disease risk. </p> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="precise" > <div class="container-fluid"> <h2 class="section-label">precise</h2> <div class="row"> <div class="col-md-12 content"> <h2>One prime editing peg<span style="text-transform: none;">RNA</span> can precisely correct the individual mutations found across many patients</h2> <p><img decoding="async" class="aligncenter size-full wp-image-236" style="width: 900px; padding: 30px 0;" src="https://primemedicine.com/wp-content/uploads/2023/05/pegRNA2.png" alt="" /></p> <p class="footnote">Abbreviations: pegRNA = Prime Editing guide RNA.</p> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="section-8" style="background-color:#f6a40c;"> <div class="container-fluid"> <div class="row"> <div class="col-md-12 content"> <h4>Precise</h4> <p>Prime Editing is designed to make only the right edit at the right position within a gene, which greatly minimizes on-target by-products at the site of editing, and results in low or minimal off-target editing in other places in the genome. Our Prime Editors do not create double-strand DNA breaks, which supports the precision of our technology. Prime Editing requires three “edit checks” or places where there must be a match between the editor and the target DNA in order to complete an edit, which we also believe leads to highly specific and precise edits. </p> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="dual-flap" > <div class="container-fluid"> <h2 class="section-label">dual flap</h2> <div class="row"> <div class="col-md-12 content"> <h2>Dual Flap – an advance on conventional Prime Editing technology</h2> <p><img decoding="async" class="aligncenter size-full wp-image-487" src="/wp-content/uploads/2023/01/extend-010523.png" alt="" width="2797" height="1375" /></p> </div> </div> </div> </div> <div class="section section-padding science-copy-block dark" id="section-10" style="background-color:#755bdf;"> <div class="container-fluid"> <div class="row"> <div class="col-md-12 content"> <h4>Dual Flap Prime Editing</h4> <p>Dual Flap Prime Editing, also known as Twin Prime Editing, uses two Prime Editors working together to make a broader range of edits at a precise location in the genome. The broader range of edits possible with this advance include looping out and deleting large genomic regions such as those occurring in repeat expansion diseases, correcting large hotspot regions in a gene, replacing or removing small exons, or inserting DNA sequences. All of these edits occur without double-strand breaks, and require the same “edit checks” as in conventional Prime Editing.</p> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="efficient" > <div class="container-fluid"> <h2 class="section-label">efficient</h2> <div class="row"> <div class="col-md-12 content"> <h2>Prime editing corrections occur at the natural place in the genome and are permanent. </h2> <p><img decoding="async" class="aligncenter size-full wp-image-237" style="width: 565px; padding: 30px 0;" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Prime_DNA_Graphic_062821a-1.png" alt="" width="2200" height="1444" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Prime_DNA_Graphic_062821a-1.png 2200w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_DNA_Graphic_062821a-1-300x197.png 300w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_DNA_Graphic_062821a-1-1024x672.png 1024w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_DNA_Graphic_062821a-1-768x504.png 768w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_DNA_Graphic_062821a-1-1536x1008.png 1536w, https://primemedicine.com/wp-content/uploads/2022/07/Prime_DNA_Graphic_062821a-1-2048x1344.png 2048w" sizes="(max-width: 2200px) 100vw, 2200px" /></p> </div> </div> </div> </div> <div class="section section-padding science-copy-block dark" id="section-12" style="background-color:#172fe9;"> <div class="container-fluid"> <div class="row"> <div class="col-md-12 content"> <h4>Efficient</h4> <p>With a single treatment, Prime Editing could permanently correct disease-causing mutations, resulting in restoration of the gene back to its wild-type, healthy sequence. A corrected gene would persist in an edited cell, working naturally and being passed along to daughter cells, leading to a potentially durable cure or therapeutic outcome. These benefits have the potential for optimal gene regulation, which we believe could result in long-lasting benefits to patients.</p> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="passige" > <div class="container-fluid"> <h2 class="section-label">passige</h2> <div class="row"> <div class="col-md-12 content"> <h2>PASSIGE™ – further extending Prime Editing to insert gene sized sequences precisely in the genome</h2> <p><img decoding="async" class="aligncenter size-full wp-image-489" src="https://primemedicine.com/wp-content/uploads/2023/01/passige-010523.png" alt="" width="3069" height="1171" /></p> <p class="footnote">Exemplary Prime Editing process using Cas and RT. Abbreviations: pegRNA = Prime Editing guide RNA; RT = reverse transcriptase; Cas = CRISPR associated protein</p> </div> </div> </div> </div> <div class="section section-padding science-copy-block dark" id="section-14" style="background-color:#5f5f5f;"> <div class="container-fluid"> <div class="row"> <div class="col-md-12 content"> <h4>PASSIGE – Precise introduction of gene-sized pieces of DNA</h4> <p>By combining Prime Editing with an integrase or site-specific recombinase enzyme we harness the precision of Prime Editing with the ability to introduce large gene-sized cargo into the genome as a potential one-time therapy for patients. This proprietary therapeutic approach, known as Prime Assisted Site Specific Integrase Gene Editing or PASSIGE, further increases the versatility of Prime Editing. We believe PASSIGE broadens the range of permanent genomic edits that Prime Editing can make to treat disease, including the ability to insert entire genes precisely into a patient’s genome. </p> </div> </div> </div> </div> <div class="section section-padding science-copy-block light" id="broad" > <div class="container-fluid"> <h2 class="section-label">broad</h2> <div class="row"> <div class="col-md-12 content"> <h2>Prime Editing can be delivered to the right place in the body using multiple modalities</h2> <div class="row hover-blocks"> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">Non-viral nanoparticle</p> <p><img decoding="async" class="aligncenter size-full wp-image-238" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Non-viral-nanoparticle.png" alt="" width="220" height="200" /></p> </div> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">RNA-protein complex</p> <p><img decoding="async" class="aligncenter size-full wp-image-240" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/RNA-protein-complex.png" alt="" width="334" height="306" srcset="https://primemedicine.com/wp-content/uploads/2022/07/RNA-protein-complex.png 334w, https://primemedicine.com/wp-content/uploads/2022/07/RNA-protein-complex-300x275.png 300w" sizes="(max-width: 334px) 100vw, 334px" /></p> </div> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">Viral vector</p> <p><img decoding="async" class="alignnone size-full wp-image-241" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/viral-vector.png" alt="" width="917" height="834" srcset="https://primemedicine.com/wp-content/uploads/2022/07/viral-vector.png 917w, https://primemedicine.com/wp-content/uploads/2022/07/viral-vector-300x273.png 300w, https://primemedicine.com/wp-content/uploads/2022/07/viral-vector-768x698.png 768w" sizes="(max-width: 917px) 100vw, 917px" /></p> </div> <div class="col-md-3 col-sm-6"> <p style="text-align: center;">Prime-Edited cell therapy</p> <p><img decoding="async" class="aligncenter size-full wp-image-239" src="https://primemedicine.wpengine.com/wp-content/uploads/2022/07/Prime-Edited-cell-therapy.png" alt="" width="310" height="290" srcset="https://primemedicine.com/wp-content/uploads/2022/07/Prime-Edited-cell-therapy.png 310w, https://primemedicine.com/wp-content/uploads/2022/07/Prime-Edited-cell-therapy-300x281.png 300w" sizes="(max-width: 310px) 100vw, 310px" /></p> </div> </div> </div> </div> </div> </div> <div class="section section-padding science-copy-block dark" id="section-16" style="background-color:#ba075c;"> <div class="container-fluid"> <div class="row"> <div class="col-md-12 content"> <h4>Broad</h4> <p>Prime Editing is a compelling approach for a wide range of therapeutic applications at the genomic level, and can make precise, targeted edits in an array of cell types, tissues and organs. We believe this breadth in applications and ability to target multiple cell types, as well as technological advances such as dual flap and PASSIGE, will enable Prime Editing to bring potentially curative gene editing approaches to a broader set of diseases, beyond rare genetic disease, to address severe, chronic, and acute common diseases with high unmet need, or replace current therapies for disease with a one-time genetic therapy. </p> </div> </div> </div> </div> <div class="section section-padding" id="scientific-publications"> <div class="container-fluid"> <h2 class="section-label">Scientific Publications & Presentations</h2> <div class="row"> <div class="col-md-12 content"> <h3>Scientific Publications & Presentations</h3> </div> </div> <div class="row news flex flex-boxes"> <div class="col-md-6 content flex flex-boxes"> <a class="news-titles" href="https://primemedicine.com/wp-content/uploads/2024/11/FLAT-West-2024-RCohen.pdf" target="_blank"> <h4>11_12_24</h4> <h4>Future Labs, Automation, & Technology West</h4> <h3>Integrate to Innovate: Strategic Approaches to Modular Automation</h3> <p>Rachael Cohen</p> </a> </div> <div class="col-md-6 content flex flex-boxes"> <a class="news-titles" href="https://primemedicine.com/wp-content/uploads/2023/05/Efficient-prime-editing-in-mouse-brain-liver-and-heart-with-dual-AAVs.pdf" target="_blank"> <h4>5_4_23</h4> <h4>nature biotechnology</h4> <h3>Efficient prime editing in mouse brain, liver and heart with dual AAVs</h3> <p>Jessie R. Davis, Samagya Banskota, Jonathan M. Levy, Gregory A. Newby, Xiao Wang, Andrew V. Anzalone, Andrew T. Nelson, Peter J. Chen, Andrew D. Hennes, Meirui An, Heejin Roh, Peyton B. Randolph, Kiran Musunuru & David R. Liu</p> </a> </div> <div class="col-md-6 content flex flex-boxes"> <a class="news-titles" href="https://www.nature.com/articles/s41587-021-01133-w" target="_blank"> <h4>12_9_21</h4> <h4>Nature Biotechnology</h4> <h3>Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing</h3> <p>Andrew V. Anzalone, Xin D. Gao, Christopher J. Podracky, Andrew T. Nelson, Luke W. Koblan, Aditya Raguram, Jonathan M. Levy, Jaron A.M. Mercer & David R. Liu</p> </a> </div> <div class="col-md-6 content flex flex-boxes"> <a class="news-titles" href="https://www.cell.com/cell/fulltext/S0092-8674(21)01065-5" target="_blank"> <h4>10_14_21</h4> <h4>cell</h4> <h3>Enhanced prime editing systems by manipulating cellular determinants of editing outcomes</h3> <p>Peter J. Chen, Jeffrey A. Hussmann, Jun Yan, Friederike Knipping, Purnima Ravisankar, Pin-Fang Chen, Cidi Chen, James W. Nelson, Gregory A. Newby, Mustafa Sahin, Mark J. Osborn, Jonathan S. Weissman, Britt Adamson & David R. Liu</p> </a> </div> <div class="col-md-12 content flex flex-boxes"> <a class="news-titles" href="https://www.nature.com/articles/s41587-021-01039-7" target="_blank"> <h4>10_4_21</h4> <h4>nature biotechnology</h4> <h3>Engineered pegRNAs improve prime editing efficiency</h3> <p>James W. Nelson, Peyton B. Randolph, Simon P. Shen, Kelcee A. Everette, Peter J. Chen, Andrew V. Anzalone, Meirui An, Gregory A. Newby, Jonathan C. Chen, Alvin Hsu & David R. Liu</p> </a> </div> <div class="col-md-6 content flex flex-boxes"> <a class="news-titles" href="https://www.nature.com/articles/s41587-020-0561-9" target="_blank"> <h4>6_22_20</h4> <h4>nature biotechnology</h4> <h3>Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors</h3> <p>Andrew V. Anzalone, Luke W. Koblan & David R. Liu</p> </a> </div> <div class="col-md-6 content flex flex-boxes"> <a class="news-titles" href="https://www.nejm.org/doi/full/10.1056/NEJMcibr1914271" target="_blank"> <h4>1_30_20</h4> <h4>new england journal of medicine</h4> <h3>Prime Time for Genome Editing?</h3> <p>Fyodor D. Urnov, Ph.D.</p> </a> </div> <div class="col-md-6 content flex flex-boxes"> <a class="news-titles" href="https://www.nature.com/articles/s41586-019-1711-4" target="_blank"> <h4>10_19_19</h4> <h4>nature</h4> <h3>Search-and-replace genome editing without double-strand breaks or donor DNA</h3> <p>Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis, Alexander A. Sousa, Luke W. Koblan, Jonathan M. Levy, Peter J. Chen, Christopher Wilson, Gregory A. Newby, Aditya Raguram & David R. 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