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Dostupno na 24 jezika" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-24" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">24 jezika</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AA%D9%87%D8%AC%D9%8A%D9%86_%D9%85%D9%88%D8%B6%D8%B9%D9%8A_%D9%85%D8%AA%D8%A3%D9%84%D9%82" title="تهجين موضعي متألق – arapski" lang="ar" hreflang="ar" data-title="تهجين موضعي متألق" data-language-autonym="العربية" data-language-local-name="arapski" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Hibridaci%C3%B3_in_situ_per_fluoresc%C3%A8ncia" title="Hibridació in situ per fluorescència – katalonski" lang="ca" hreflang="ca" data-title="Hibridació in situ per fluorescència" data-language-autonym="Català" data-language-local-name="katalonski" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Fluorescen%C4%8Dn%C3%AD_in_situ_hybridizace" title="Fluorescenční in situ hybridizace – češki" lang="cs" hreflang="cs" data-title="Fluorescenční in situ hybridizace" data-language-autonym="Čeština" data-language-local-name="češki" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/FISH-Test" title="FISH-Test – njemački" lang="de" hreflang="de" data-title="FISH-Test" data-language-autonym="Deutsch" data-language-local-name="njemački" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%9C%CE%AD%CE%B8%CE%BF%CE%B4%CE%BF%CF%82_FISH" title="Μέθοδος FISH – grčki" lang="el" hreflang="el" data-title="Μέθοδος FISH" data-language-autonym="Ελληνικά" data-language-local-name="grčki" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Fluorescence_in_situ_hybridization" title="Fluorescence in situ hybridization – engleski" lang="en" hreflang="en" data-title="Fluorescence in situ hybridization" data-language-autonym="English" data-language-local-name="engleski" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Hibridaci%C3%B3n_fluorescente_in_situ" title="Hibridación fluorescente in situ – španski" lang="es" hreflang="es" data-title="Hibridación fluorescente in situ" data-language-autonym="Español" data-language-local-name="španski" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Hybridation_in_situ_en_fluorescence" title="Hybridation in situ en fluorescence – francuski" lang="fr" hreflang="fr" data-title="Hybridation in situ en fluorescence" data-language-autonym="Français" data-language-local-name="francuski" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Hibridaci%C3%B3n_in_situ_fluorescente" title="Hibridación in situ fluorescente – galicijski" lang="gl" hreflang="gl" data-title="Hibridación in situ fluorescente" data-language-autonym="Galego" data-language-local-name="galicijski" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%94%D7%99%D7%91%D7%A8%D7%99%D7%93%D7%99%D7%96%D7%A6%D7%99%D7%94_%D7%A4%D7%9C%D7%95%D7%90%D7%95%D7%A8%D7%A1%D7%A6%D7%A0%D7%98%D7%99%D7%AA_%D7%91%D7%90%D7%AA%D7%A8" title="היברידיזציה פלואורסצנטית באתר – hebrejski" lang="he" hreflang="he" data-title="היברידיזציה פלואורסצנטית באתר" data-language-autonym="עברית" data-language-local-name="hebrejski" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/FISH" title="FISH – hrvatski" lang="hr" hreflang="hr" data-title="FISH" data-language-autonym="Hrvatski" data-language-local-name="hrvatski" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/FISH" title="FISH – mađarski" lang="hu" hreflang="hu" data-title="FISH" data-language-autonym="Magyar" data-language-local-name="mađarski" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Ibridazione_fluorescente_in_situ" title="Ibridazione fluorescente in situ – italijanski" lang="it" hreflang="it" data-title="Ibridazione fluorescente in situ" data-language-autonym="Italiano" data-language-local-name="italijanski" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E8%9B%8D%E5%85%89_in_situ_%E3%83%8F%E3%82%A4%E3%83%96%E3%83%AA%E3%83%80%E3%82%A4%E3%82%BC%E3%83%BC%E3%82%B7%E3%83%A7%E3%83%B3" title="蛍光 in situ ハイブリダイゼーション – japanski" lang="ja" hreflang="ja" data-title="蛍光 in situ ハイブリダイゼーション" data-language-autonym="日本語" data-language-local-name="japanski" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Chromosom%C5%B3_da%C5%BEymas" title="Chromosomų dažymas – litvanski" lang="lt" hreflang="lt" data-title="Chromosomų dažymas" data-language-autonym="Lietuvių" data-language-local-name="litvanski" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Fluorescentie-in-situhybridisatie" title="Fluorescentie-in-situhybridisatie – nizozemski" lang="nl" hreflang="nl" data-title="Fluorescentie-in-situhybridisatie" data-language-autonym="Nederlands" data-language-local-name="nizozemski" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Fluorescencyjna_hybrydyzacja_in_situ" title="Fluorescencyjna hybrydyzacja in situ – poljski" lang="pl" hreflang="pl" data-title="Fluorescencyjna hybrydyzacja in situ" data-language-autonym="Polski" data-language-local-name="poljski" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Hibridiza%C3%A7%C3%A3o_fluorescente_in_situ" title="Hibridização fluorescente in situ – portugalski" lang="pt" hreflang="pt" data-title="Hibridização fluorescente in situ" data-language-autonym="Português" data-language-local-name="portugalski" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%A4%D0%BB%D1%83%D0%BE%D1%80%D0%B5%D1%81%D1%86%D0%B5%D0%BD%D1%82%D0%BD%D0%B0%D1%8F_%D0%B3%D0%B8%D0%B1%D1%80%D0%B8%D0%B4%D0%B8%D0%B7%D0%B0%D1%86%D0%B8%D1%8F_in_situ" title="Флуоресцентная гибридизация in situ – ruski" lang="ru" hreflang="ru" data-title="Флуоресцентная гибридизация in situ" data-language-autonym="Русский" data-language-local-name="ruski" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Fluorescerande_in_situ-hybridisering" title="Fluorescerande in situ-hybridisering – švedski" lang="sv" hreflang="sv" data-title="Fluorescerande in situ-hybridisering" data-language-autonym="Svenska" data-language-local-name="švedski" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Floresan_in_situ_hibridizasyon" title="Floresan in situ hibridizasyon – turski" lang="tr" hreflang="tr" data-title="Floresan in situ hibridizasyon" data-language-autonym="Türkçe" data-language-local-name="turski" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%A4%D0%BB%D1%8E%D0%BE%D1%80%D0%B5%D1%81%D1%86%D0%B5%D0%BD%D1%82%D0%BD%D0%B0_%D0%B3%D1%96%D0%B1%D1%80%D0%B8%D0%B4%D0%B8%D0%B7%D0%B0%D1%86%D1%96%D1%8F_in_situ" title="Флюоресцентна гібридизація in situ – ukrajinski" lang="uk" hreflang="uk" data-title="Флюоресцентна гібридизація in situ" data-language-autonym="Українська" data-language-local-name="ukrajinski" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-ur mw-list-item"><a href="https://ur.wikipedia.org/wiki/%D8%AA%D8%A7%D9%84%D9%82%DB%8C_%D8%AA%DB%81%D8%AC%DB%8C%D9%86_%D8%AF%D8%B1_%D9%85%D9%88%D9%82%D8%B9" title="تالقی تہجین در موقع – urdu" lang="ur" hreflang="ur" data-title="تالقی تہجین در موقع" data-language-autonym="اردو" data-language-local-name="urdu" class="interlanguage-link-target"><span>اردو</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a 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typeof="mw:File/Thumb"><a href="/wiki/Datoteka:Multiplex_ViewRNA_FISH_Assay_in_Jurkat_and_HeLa_cells.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Multiplex_ViewRNA_FISH_Assay_in_Jurkat_and_HeLa_cells.jpg/220px-Multiplex_ViewRNA_FISH_Assay_in_Jurkat_and_HeLa_cells.jpg" decoding="async" width="220" height="110" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Multiplex_ViewRNA_FISH_Assay_in_Jurkat_and_HeLa_cells.jpg/330px-Multiplex_ViewRNA_FISH_Assay_in_Jurkat_and_HeLa_cells.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a1/Multiplex_ViewRNA_FISH_Assay_in_Jurkat_and_HeLa_cells.jpg/440px-Multiplex_ViewRNA_FISH_Assay_in_Jurkat_and_HeLa_cells.jpg 2x" data-file-width="500" data-file-height="250" /></a><figcaption>Multipleksna vizualizacija <a href="/wiki/RNK" class="mw-redirect" title="RNK">RNK</a> u ćelijama tretiranim u <i>ViewRNK</i> <b><a href="/wiki/FISH" class="mw-redirect" title="FISH">FISH</a></b> eseju</figcaption></figure> <figure class="mw-default-size mw-halign-right" typeof="mw:File/Thumb"><a href="/wiki/Datoteka:Bcrablmet.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/d/dc/Bcrablmet.jpg" decoding="async" width="213" height="244" class="mw-file-element" data-file-width="213" data-file-height="244" /></a><figcaption>Pozitivne <a href="/wiki/Metafaza" class="mw-redirect" title="Metafaza">metafazne</a> ćelije za <i>bcr/abl</i> rearanžman (udružen sa hroničnom mijeloidnom leukemijom), nakoh FISH tretmana. <br />Hromosomi su plavi.<br /> Oni koji su obilježeni zeleno <i>i</i> crveno (gore lijevo) su sa prisutnim rearanžmanom.</figcaption></figure> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/Datoteka:MicroRNA_and_mRNA_visualization_in_differentiating_C1C12_cells.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/MicroRNA_and_mRNA_visualization_in_differentiating_C1C12_cells.jpg/220px-MicroRNA_and_mRNA_visualization_in_differentiating_C1C12_cells.jpg" decoding="async" width="220" height="160" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/MicroRNA_and_mRNA_visualization_in_differentiating_C1C12_cells.jpg/330px-MicroRNA_and_mRNA_visualization_in_differentiating_C1C12_cells.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/MicroRNA_and_mRNA_visualization_in_differentiating_C1C12_cells.jpg/440px-MicroRNA_and_mRNA_visualization_in_differentiating_C1C12_cells.jpg 2x" data-file-width="1156" data-file-height="842" /></a><figcaption>Detekcija RNK – mR-133 gena (zeleno) i miogenin <a href="/wiki/MRNK" class="mw-redirect" title="MRNK">mRNK</a> (crveno) u C2C12 diferencirajućim ćelijama</figcaption></figure> <p><b>Fluorescentna <i>in situ</i> hibridizacija</b> (<b>F</b>luorescence <b>I</b>n situ <b>H</b>ybridisation: <b><a href="/wiki/FISH" class="mw-redirect" title="FISH">FISH</a></b>) je <a href="/wiki/Citogenetika" title="Citogenetika">citogenetička</a> tehnika razvijena u biomedicinskim istraživanjima ranih 1980-ih, kada je primijenjena za otkrivanje i lokalizaciju prisustva/odsustva specifičnih <a href="/wiki/DNK" class="mw-redirect" title="DNK">DNK</a> sekvenci na <a href="/wiki/Hromosom" title="Hromosom">hromosomima</a>. FISH upotrebljava fluorescentne probe koje se vežu samo za one dijelove hromosoma sa kojima ispoljavaju visok stepen komplementarnosti sekvenci. Da bi se ustanovilo mjesto vezanja fluorescentnih proba za hromosome neophodna je <a href="/w/index.php?title=Fluoroscentna_mikroskopija&action=edit&redlink=1" class="new" title="Fluoroscentna mikroskopija (stranica ne postoji)">fluoroscentna mikroskopija</a>. </p><p>FISH se često primjenjuje za traženje specifičnih pojava u <a href="/wiki/DNK" class="mw-redirect" title="DNK">DNK</a> za upotrebu u <a href="/wiki/Geneti%C4%8Dka_konsultacija" title="Genetička konsultacija">genetičkom konsultiranju</a>, <a href="/wiki/Medicina" title="Medicina">medicini</a> i identificiranju <a href="/wiki/Vrsta" class="mw-disambig" title="Vrsta">vrsta</a>. Također je primjenjiv u otkrivanju i lokalizaciji <a href="/wiki/RNK" class="mw-redirect" title="RNK">RNK</a> ciljeva (<a href="/wiki/MRNK" class="mw-redirect" title="MRNK">mRNK</a>), dugih nekodirajućih segmenata RNK (lncRNK) i <i>miRNK</i> u ćelijama, cirkulirajućim tumorskim ćelijama i <a href="/wiki/Tkivo" title="Tkivo">tkivnim</a> uzorcima. U tom smislu, može pomoći za definiranje prostorno-vremenskih osobenosti <a href="/wiki/Ekspresija_gena" title="Ekspresija gena">ekspresije gena</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Reference">Reference</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fluorescentna_%27%27in_situ%27%27_hibridizacija&veaction=edit&section=1" title="Uredi odlomak "Reference"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Fluorescentna_%27%27in_situ%27%27_hibridizacija&action=edit&section=1" title="Edit section's source code: Reference"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r3312388">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text">Bajrović K, Jevrić-Čaušević A., Hadžiselimović R., Ed. (2005): Uvod u genetičko inženjerstvo i biotehnologiju. Institut za genetičko inženjerstvo i biotehnologiju (INGEB), Sarajevo, <a href="/wiki/International_Standard_Book_Number" title="International Standard Book Number">ISBN</a> <a href="/wiki/Posebno:Knji%C5%BEni_izvori/9958-9344-1-8" title="Posebno:Knjižni izvori/9958-9344-1-8">9958-9344-1-8</a>.</span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Također_pogledajte"><span id="Tako.C4.91er_pogledajte"></span>Također pogledajte</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Fluorescentna_%27%27in_situ%27%27_hibridizacija&veaction=edit&section=2" title="Uredi odlomak "Također pogledajte"" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Fluorescentna_%27%27in_situ%27%27_hibridizacija&action=edit&section=2" title="Edit section's source code: Također pogledajte"><span>uredi izvor</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Citogenetika" title="Citogenetika">Citogenetika</a></li> <li><a href="/wiki/Nukleinske_kiseline" title="Nukleinske kiseline">Nukleinske kiseline</a></li> <li><a href="/wiki/Genski_pi%C5%A1tolj" title="Genski pištolj">Genski pištolj</a></li> <li><a href="/wiki/Elektroporacija" title="Elektroporacija">Elektroporacija</a></li> <li><a href="/wiki/Biolistika" class="mw-redirect" title="Biolistika">Biolistika</a></li></ul></div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Preuzeto iz "<a dir="ltr" href="https://bs.wikipedia.org/w/index.php?title=Fluorescentna_%27%27in_situ%27%27_hibridizacija&oldid=3248148">https://bs.wikipedia.org/w/index.php?title=Fluorescentna_%27%27in_situ%27%27_hibridizacija&oldid=3248148</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Posebno:Kategorije" title="Posebno:Kategorije">Kategorije</a>: <ul><li><a href="/wiki/Kategorija:Molekularna_genetika" title="Kategorija:Molekularna genetika">Molekularna genetika</a></li><li><a href="/wiki/Kategorija:Citogenetika" title="Kategorija:Citogenetika">Citogenetika</a></li><li><a href="/wiki/Kategorija:Hromosomi" title="Kategorija:Hromosomi">Hromosomi</a></li><li><a href="/wiki/Kategorija:Nukleinske_kiseline" title="Kategorija:Nukleinske kiseline">Nukleinske kiseline</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> Ova stranica je posljednji put izmijenjena na datum 16 januar 2021 u 22:22.</li> <li id="footer-info-copyright">Tekst je dostupan pod <a rel="nofollow" class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/">slobodnom licencom Autorstvo-Dijeliti pod istim uvjetima</a>; mogu se primijeniti i dodatni uvjeti. 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