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vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">yashirish</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Kirish</div> </a> </li> <li id="toc-Qoʻllanilishi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Qoʻllanilishi"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Qoʻllanilishi</span> </div> </a> <button aria-controls="toc-Qoʻllanilishi-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Qoʻllanilishi subsection</span> </button> <ul id="toc-Qoʻllanilishi-sublist" class="vector-toc-list"> <li id="toc-Peptik_yaralarda" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Peptik_yaralarda"> <div class="vector-toc-text"> <span class="vector-toc-numb">1.1</span> <span>Peptik yaralarda</span> </div> </a> <ul id="toc-Peptik_yaralarda-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Nojoʻya_taʻsirlari" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Nojoʻya_taʻsirlari"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Nojoʻya taʻsirlari</span> </div> </a> <button aria-controls="toc-Nojoʻya_taʻsirlari-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Nojoʻya taʻsirlari subsection</span> </button> <ul id="toc-Nojoʻya_taʻsirlari-sublist" class="vector-toc-list"> <li id="toc-Uzoq_muddatli_foydalanish" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Uzoq_muddatli_foydalanish"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Uzoq muddatli foydalanish</span> </div> </a> <ul id="toc-Uzoq_muddatli_foydalanish-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Homiladorlik_va_emizish_davrida_qoʻllanishi" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Homiladorlik_va_emizish_davrida_qoʻllanishi"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Homiladorlik va emizish davrida qoʻllanishi</span> </div> </a> <ul id="toc-Homiladorlik_va_emizish_davrida_qoʻllanishi-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Dorilarning_oʻzaro_taʻsiri" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Dorilarning_oʻzaro_taʻsiri"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Dorilarning oʻzaro taʻsiri</span> </div> </a> <ul id="toc-Dorilarning_oʻzaro_taʻsiri-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Farmakologik_xususiyatlari" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Farmakologik_xususiyatlari"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Farmakologik xususiyatlari</span> </div> </a> <button aria-controls="toc-Farmakologik_xususiyatlari-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Farmakologik xususiyatlari subsection</span> </button> <ul id="toc-Farmakologik_xususiyatlari-sublist" class="vector-toc-list"> <li id="toc-Farmakodinamikasi" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Farmakodinamikasi"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Farmakodinamikasi</span> </div> </a> <ul id="toc-Farmakodinamikasi-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Farmakokinetikasi" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Farmakokinetikasi"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Farmakokinetikasi</span> </div> </a> <ul id="toc-Farmakokinetikasi-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Kimyoviy_xossalari" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Kimyoviy_xossalari"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Kimyoviy xossalari</span> </div> </a> <button aria-controls="toc-Kimyoviy_xossalari-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Kimyoviy xossalari subsection</span> </button> <ul id="toc-Kimyoviy_xossalari-sublist" class="vector-toc-list"> <li id="toc-Tana_suyuqliklarida_oʻlchash" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Tana_suyuqliklarida_oʻlchash"> <div class="vector-toc-text"> <span class="vector-toc-numb">5.1</span> <span>Tana suyuqliklarida oʻlchash</span> </div> </a> <ul id="toc-Tana_suyuqliklarida_oʻlchash-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Tarixi" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Tarixi"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Tarixi</span> </div> </a> <ul id="toc-Tarixi-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Chiqarilish_shakli" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Chiqarilish_shakli"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Chiqarilish shakli</span> </div> </a> <button aria-controls="toc-Chiqarilish_shakli-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Chiqarilish shakli subsection</span> </button> <ul id="toc-Chiqarilish_shakli-sublist" class="vector-toc-list"> <li id="toc-Dozalash_shakllari" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Dozalash_shakllari"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.1</span> <span>Dozalash shakllari</span> </div> </a> <ul id="toc-Dozalash_shakllari-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Brend_nomlari" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Brend_nomlari"> <div class="vector-toc-text"> <span class="vector-toc-numb">7.2</span> <span>Brend nomlari</span> </div> </a> <ul id="toc-Brend_nomlari-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Manbalar" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Manbalar"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Manbalar</span> </div> </a> <ul id="toc-Manbalar-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Mundarija" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Mundarija" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Omeprazol</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Boshqa tildagi maqolaga oʻting. 45 ta tilda mavjud" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-45" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">45 ta til</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A3%D9%88%D9%85%D9%8A%D8%A8%D8%B1%D8%A7%D8%B2%D9%88%D9%84" title="أوميبرازول – arab" lang="ar" hreflang="ar" data-title="أوميبرازول" data-language-autonym="العربية" data-language-local-name="arab" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%A7%D9%85%D9%BE%D8%B1%D8%A7%D8%B2%D9%88%D9%84" title="امپرازول – South Azerbaijani" lang="azb" hreflang="azb" data-title="امپرازول" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%93%E0%A6%AE%E0%A6%BF%E0%A6%AA%E0%A7%8D%E0%A6%B0%E0%A6%BE%E0%A6%9C%E0%A6%B2" title="ওমিপ্রাজল – bengal" lang="bn" hreflang="bn" data-title="ওমিপ্রাজল" data-language-autonym="বাংলা" data-language-local-name="bengal" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Omeprazole" title="Omeprazole – katalan" lang="ca" hreflang="ca" data-title="Omeprazole" data-language-autonym="Català" data-language-local-name="katalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-ckb mw-list-item"><a href="https://ckb.wikipedia.org/wiki/%D8%A6%DB%86%D9%85%DB%8C%D9%BE%DA%95%D8%A7%D8%B2%DB%86%DA%B5" title="ئۆمیپڕازۆڵ – sorani-kurd" lang="ckb" hreflang="ckb" data-title="ئۆمیپڕازۆڵ" data-language-autonym="کوردی" data-language-local-name="sorani-kurd" class="interlanguage-link-target"><span>کوردی</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Omeprazol" title="Omeprazol – chex" lang="cs" hreflang="cs" data-title="Omeprazol" data-language-autonym="Čeština" data-language-local-name="chex" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Omeprasol" title="Omeprasol – valliy" lang="cy" hreflang="cy" data-title="Omeprasol" data-language-autonym="Cymraeg" data-language-local-name="valliy" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Omeprazol" title="Omeprazol – nemischa" lang="de" hreflang="de" data-title="Omeprazol" data-language-autonym="Deutsch" data-language-local-name="nemischa" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%9F%CE%BC%CE%B5%CF%80%CF%81%CE%B1%CE%B6%CF%8C%CE%BB%CE%B7" title="Ομεπραζόλη – grek" lang="el" hreflang="el" data-title="Ομεπραζόλη" data-language-autonym="Ελληνικά" data-language-local-name="grek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Omeprazole" title="Omeprazole – inglizcha" lang="en" hreflang="en" data-title="Omeprazole" data-language-autonym="English" data-language-local-name="inglizcha" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Omeprazolo" title="Omeprazolo – esperanto" lang="eo" hreflang="eo" data-title="Omeprazolo" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Omeprazol" title="Omeprazol – ispancha" lang="es" hreflang="es" data-title="Omeprazol" data-language-autonym="Español" data-language-local-name="ispancha" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Omeprazol" title="Omeprazol – bask" lang="eu" hreflang="eu" data-title="Omeprazol" data-language-autonym="Euskara" data-language-local-name="bask" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A7%D9%85%D9%BE%D8%B1%D8%A7%D8%B2%D9%88%D9%84" title="امپرازول – fors" lang="fa" hreflang="fa" data-title="امپرازول" data-language-autonym="فارسی" data-language-local-name="fors" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Omepratsoli" title="Omepratsoli – fincha" lang="fi" hreflang="fi" data-title="Omepratsoli" data-language-autonym="Suomi" data-language-local-name="fincha" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Om%C3%A9prazole" title="Oméprazole – fransuzcha" lang="fr" hreflang="fr" data-title="Oméprazole" data-language-autonym="Français" data-language-local-name="fransuzcha" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Omeprazole" title="Omeprazole – galisiy" lang="gl" hreflang="gl" data-title="Omeprazole" data-language-autonym="Galego" data-language-local-name="galisiy" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%95%D7%9E%D7%A4%D7%A8%D7%96%D7%95%D7%9C" title="אומפרזול – ivrit" lang="he" hreflang="he" data-title="אומפרזול" data-language-autonym="עברית" data-language-local-name="ivrit" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/Omeprazol" title="Omeprazol – xorvat" lang="hr" hreflang="hr" data-title="Omeprazol" data-language-autonym="Hrvatski" data-language-local-name="xorvat" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Omeprazol" title="Omeprazol – venger" lang="hu" hreflang="hu" data-title="Omeprazol" data-language-autonym="Magyar" data-language-local-name="venger" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D5%95%D5%B4%D5%A5%D5%BA%D6%80%D5%A1%D5%A6%D5%B8%D5%AC" title="Օմեպրազոլ – arman" lang="hy" hreflang="hy" data-title="Օմեպրազոլ" data-language-autonym="Հայերեն" data-language-local-name="arman" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Omeprazol" title="Omeprazol – indonez" lang="id" hreflang="id" data-title="Omeprazol" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonez" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Omeprazolo" title="Omeprazolo – italyan" lang="it" hreflang="it" data-title="Omeprazolo" data-language-autonym="Italiano" data-language-local-name="italyan" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%AA%E3%83%A1%E3%83%97%E3%83%A9%E3%82%BE%E3%83%BC%E3%83%AB" title="オメプラゾール – yapon" lang="ja" hreflang="ja" data-title="オメプラゾール" data-language-autonym="日本語" data-language-local-name="yapon" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%9E%D0%BC%D0%B5%D0%BF%D1%80%D0%B0%D0%B7%D0%BE%D0%BB" title="Омепразол – qozoqcha" lang="kk" hreflang="kk" data-title="Омепразол" data-language-autonym="Қазақша" data-language-local-name="qozoqcha" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%98%A4%EB%A9%94%ED%94%84%EB%9D%BC%EC%A1%B8" title="오메프라졸 – koreyscha" lang="ko" hreflang="ko" data-title="오메프라졸" data-language-autonym="한국어" data-language-local-name="koreyscha" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ks mw-list-item"><a href="https://ks.wikipedia.org/wiki/%D8%A7%D9%88%D9%85%DB%8C%D9%BE%D8%B1%D8%A7%D8%B2%D9%88%D9%84" title="اومیپرازول – kashmircha" lang="ks" hreflang="ks" data-title="اومیپرازول" data-language-autonym="कॉशुर / کٲشُر" data-language-local-name="kashmircha" class="interlanguage-link-target"><span>कॉशुर / کٲشُر</span></a></li><li class="interlanguage-link interwiki-mk mw-list-item"><a href="https://mk.wikipedia.org/wiki/%D0%9E%D0%BC%D0%B5%D0%BF%D1%80%D0%B0%D0%B7%D0%BE%D0%BB" title="Омепразол – makedon" lang="mk" hreflang="mk" data-title="Омепразол" data-language-autonym="Македонски" data-language-local-name="makedon" class="interlanguage-link-target"><span>Македонски</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Omeprazol" title="Omeprazol – niderland" lang="nl" hreflang="nl" data-title="Omeprazol" data-language-autonym="Nederlands" data-language-local-name="niderland" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%93%E0%AC%AE%E0%AD%87%E0%AC%AA%E0%AD%8D%E0%AC%B0%E0%AC%BE%E0%AC%9C%E0%AD%8B%E0%AC%B2" title="ଓମେପ୍ରାଜୋଲ – oriya" lang="or" hreflang="or" data-title="ଓମେପ୍ରାଜୋଲ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="oriya" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Omeprazol" title="Omeprazol – polyakcha" lang="pl" hreflang="pl" data-title="Omeprazol" data-language-autonym="Polski" data-language-local-name="polyakcha" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D8%A7%D9%88%D9%85%D9%8A%D9%BE%D8%B1%D8%A7%D8%B2%D9%88%D9%84" title="اوميپرازول – pushtu" lang="ps" hreflang="ps" data-title="اوميپرازول" data-language-autonym="پښتو" data-language-local-name="pushtu" class="interlanguage-link-target"><span>پښتو</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Omeprazol" title="Omeprazol – portugalcha" lang="pt" hreflang="pt" data-title="Omeprazol" data-language-autonym="Português" data-language-local-name="portugalcha" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Omeprazol" title="Omeprazol – rumincha" lang="ro" hreflang="ro" data-title="Omeprazol" data-language-autonym="Română" data-language-local-name="rumincha" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9E%D0%BC%D0%B5%D0%BF%D1%80%D0%B0%D0%B7%D0%BE%D0%BB" title="Омепразол – ruscha" lang="ru" hreflang="ru" data-title="Омепразол" data-language-autonym="Русский" data-language-local-name="ruscha" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Omeprazol" title="Omeprazol – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Omeprazol" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sk mw-list-item"><a href="https://sk.wikipedia.org/wiki/Omeprazol" title="Omeprazol – slovakcha" lang="sk" hreflang="sk" data-title="Omeprazol" data-language-autonym="Slovenčina" data-language-local-name="slovakcha" class="interlanguage-link-target"><span>Slovenčina</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Omeprazol" title="Omeprazol – slovencha" lang="sl" hreflang="sl" data-title="Omeprazol" data-language-autonym="Slovenščina" data-language-local-name="slovencha" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Omeprazol" title="Omeprazol – serbcha" lang="sr" hreflang="sr" data-title="Omeprazol" data-language-autonym="Српски / srpski" data-language-local-name="serbcha" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Omeprazol" title="Omeprazol – shved" lang="sv" hreflang="sv" data-title="Omeprazol" data-language-autonym="Svenska" data-language-local-name="shved" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%82%E0%B8%AD%E0%B9%80%E0%B8%A1%E0%B8%9B%E0%B8%A3%E0%B8%B2%E0%B9%82%E0%B8%8B%E0%B8%A5" title="โอเมปราโซล – tay" lang="th" hreflang="th" data-title="โอเมปราโซล" data-language-autonym="ไทย" data-language-local-name="tay" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Omeprazol" title="Omeprazol – turk" lang="tr" hreflang="tr" data-title="Omeprazol" data-language-autonym="Türkçe" data-language-local-name="turk" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9E%D0%BC%D0%B5%D0%BF%D1%80%D0%B0%D0%B7%D0%BE%D0%BB" title="Омепразол – ukrain" lang="uk" hreflang="uk" data-title="Омепразол" data-language-autonym="Українська" data-language-local-name="ukrain" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Omeprazole" title="Omeprazole – vyetnam" lang="vi" hreflang="vi" data-title="Omeprazole" data-language-autonym="Tiếng Việt" data-language-local-name="vyetnam" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%A5%A5%E7%BE%8E%E6%8B%89%E5%94%91" title="奥美拉唑 – xitoy" lang="zh" hreflang="zh" data-title="奥美拉唑" data-language-autonym="中文" data-language-local-name="xitoy" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q422210#sitelinks-wikipedia" title="Tillararo ishoratlarni tahrirlash" class="wbc-editpage">Ishoratlarni tahrirla</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Nomfazolar"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Omeprazol" title="Sahifani ko‘rish [c]" accesskey="c"><span>Maqola</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Munozara:Omeprazol" rel="discussion" title="Sahifa matni borasida munozara [t]" accesskey="t"><span>Munozara</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown " > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Til variantini oʻzgartirish" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">lotin/кирилл</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-varlang-0" class="selected ca-variants-uz mw-list-item"><a href="/w/index.php?title=Omeprazol&variant=uz" lang="uz" hreflang="uz"><span>lotin/кирилл</span></a></li><li id="ca-varlang-1" class="ca-variants-uz-Latn mw-list-item"><a href="/w/index.php?title=Omeprazol&variant=uz-latn" lang="uz-Latn" hreflang="uz-Latn"><span>lotin</span></a></li><li id="ca-varlang-2" class="ca-variants-uz-Cyrl mw-list-item"><a href="/w/index.php?title=Omeprazol&variant=uz-cyrl" lang="uz-Cyrl" hreflang="uz-Cyrl"><span>кирилл</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Koʻrinishlar"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Omeprazol"><span>Mutolaa</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Omeprazol&veaction=edit" title="Bu sahifani tahrirlash [v]" accesskey="v"><span>Tahrirlash</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Omeprazol&action=edit" title="Sahifa manba kodini tahrirlash [e]" accesskey="e"><span>Manbasini tahrirlash</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Omeprazol&action=history" title="Bu sahifaning oʻzgarishlar tarixi [h]" accesskey="h"><span>Tarix</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Asboblar" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Asboblar</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Asboblar</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">yonqutiga oʻtish</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">yashirish</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Koʻproq opsiyalar" > <div class="vector-menu-heading"> Amallar </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Omeprazol"><span>Mutolaa</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Omeprazol&veaction=edit" title="Bu sahifani tahrirlash [v]" accesskey="v"><span>Tahrirlash</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Omeprazol&action=edit" title="Sahifa manba kodini tahrirlash [e]" accesskey="e"><span>Manbasini tahrirlash</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Omeprazol&action=history"><span>Tarix</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Umumiy </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Maxsus:WhatLinksHere/Omeprazol" title="Ushbu sahifaga bogʻlangan sahifalar roʻyxati [j]" accesskey="j"><span>Bu yerga ishoratlar</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Maxsus:RecentChangesLinked/Omeprazol" rel="nofollow" title="Bu sahifaga bogʻlangan sahifalardagi yangi oʻzgarishlar [k]" accesskey="k"><span>Bogʻliq oʻzgarishlar</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Omeprazol&oldid=5374076" title="Sahifaning ushbu versiyasiga doimiy ishorat"><span>Doimiy havola</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Omeprazol&action=info" title="Bu sahifa haqida koʻproq maʼlumot"><span>Sahifa haqida maʼlumot</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Maxsus:CiteThisPage&page=Omeprazol&id=5374076&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Sahifadan matn parchasi ajratish</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Maxsus:UrlShortener&url=https%3A%2F%2Fuz.wikipedia.org%2Fwiki%2FOmeprazol"><span>Qisqartirilgan URL-manzilni olish</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Maxsus:QrCode&url=https%3A%2F%2Fuz.wikipedia.org%2Fwiki%2FOmeprazol"><span>QR-kodni yuklab olish</span></a></li> </ul> </div> </div> <div id="p-electronpdfservice-sidebar-portlet-heading" class="vector-menu mw-portlet mw-portlet-electronpdfservice-sidebar-portlet-heading" > <div class="vector-menu-heading"> Nashr/eksport qilish </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="electron-print_pdf" class="mw-list-item"><a href="/w/index.php?title=Maxsus:DownloadAsPdf&page=Omeprazol&action=show-download-screen"><span>PDF sifatida yuklash</span></a></li><li id="t-print" class="mw-list-item"><a href="javascript:print();" rel="alternate" title="Ushbu sahifaning bosma uchun versiyasi [p]" accesskey="p"><span>Bosma uchun versiya</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> Boshqa loyihalarda </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Omeprazole" hreflang="en"><span>Vikiombor</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q422210" title="Link to connected data repository item [g]" accesskey="g"><span>Vikimaʼlumotlar bandi</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Qiyofa"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Qiyofa</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">yonqutiga oʻtish</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">yashirish</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Vikipediya, erkin ensiklopediya</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="uz" dir="ltr"><table id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border="0" cellpadding="1" align="right" width="280"> <tbody><tr> <td align="center" colspan="2"><span typeof="mw:File"><a href="/wiki/Fayl:Omeprazole-3D-balls.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Omeprazole-3D-balls.png/220px-Omeprazole-3D-balls.png" decoding="async" width="220" height="122" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/64/Omeprazole-3D-balls.png/330px-Omeprazole-3D-balls.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/64/Omeprazole-3D-balls.png/440px-Omeprazole-3D-balls.png 2x" data-file-width="1100" data-file-height="611" /></a></span> </td></tr> <tr> <td align="center" colspan="2"><span typeof="mw:File"><a href="/wiki/Fayl:Omeprazole_20mg.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Omeprazole_20mg.jpg/220px-Omeprazole_20mg.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Omeprazole_20mg.jpg/330px-Omeprazole_20mg.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Omeprazole_20mg.jpg/440px-Omeprazole_20mg.jpg 2x" data-file-width="2048" data-file-height="1536" /></a></span> </td></tr> <tr> <td align="center" colspan="2"><div style="font-size:medium; line-height:167%;"> </div> </td></tr> <tr> <td align="center" colspan="2" bgcolor="#dddddd"><b>Sistematik (<a href="/w/index.php?title=IUPAC&action=edit&redlink=1" class="new" title="IUPAC (sahifa yaratilmagan)">IUPAC</a>) nomi</b> </td></tr> <tr> <td bgcolor="#eeeeee" style="text-align: center; vertical-align: top;" colspan="2"><span style="font-size:11px">5-Methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methanesulfinyl]-1<i>H</i>-benzimidazole</span> </td></tr> <tr> <td colspan="2" bgcolor="#dddddd"><b>Identifikatorlar</b> </td></tr> <tr> <td bgcolor="#ddeeff" width="90"><a href="/w/index.php?title=CAS_raqami&action=edit&redlink=1" class="new" title="CAS raqami (sahifa yaratilmagan)">CAS raqami</a> </td> <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://www.nlm.nih.gov/cgi/mesh/2006/MB_cgi?term=73590-58-6&rn=1">73590-58-6</a></span> </td></tr> <tr> <td bgcolor="#ddeeff"><a href="/w/index.php?title=Anatomik_Terapevtik_Kimyoviy_Klassifikatsiya_Tizimi&action=edit&redlink=1" class="new" title="Anatomik Terapevtik Kimyoviy Klassifikatsiya Tizimi (sahifa yaratilmagan)">ATK kodi</a> </td> <td bgcolor="#eeeeee"><a href="/w/index.php?title=ATC_kodi_A02&action=edit&redlink=1" class="new" title="ATC kodi A02 (sahifa yaratilmagan)">A02</a><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://www.whocc.no/atcddd/indexdatabase/index.php?query=A02BC01">BC01</a></span> </td></tr> <tr> <td bgcolor="#ddeeff"><a href="/w/index.php?title=PubChem&action=edit&redlink=1" class="new" title="PubChem (sahifa yaratilmagan)">PubChem</a> </td> <td bgcolor="#eeeeee"><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4594">4594</a></span> </td></tr> <tr> <td colspan="2" bgcolor="#dddddd"><b>Kimyoviy maʼlumot</b> </td></tr> <tr> <td bgcolor="#ddeeff"><a href="/wiki/Kimyoviy_formula" class="mw-redirect" title="Kimyoviy formula">Formulasi</a></td> <td bgcolor="#eeeeee"><a href="/wiki/Uglerod" title="Uglerod"><span style="color: rgb(000,000,000); font-weight: bold;">C</span></a><sub>17</sub><a href="/wiki/Vodorod" title="Vodorod"><span style="color: rgb(77,77,77); font-weight: bold;">H</span></a><sub>19</sub><a href="/wiki/Azot" title="Azot"><span style="color: rgb(0,0,128); font-weight: bold;">N</span></a><sub>3</sub><a href="/wiki/Kislorod" title="Kislorod"><span style="color: rgb(116,35,35); font-weight: bold;">O</span></a><sub>3</sub><a href="/wiki/Oltingugurt" title="Oltingugurt"><span style="color: rgb(114,97,31); font-weight: bold;">S</span></a><sup> </sup> </td></tr> <tr> <td bgcolor="#ddeeff"><a href="/w/index.php?title=Molekular_massasi&action=edit&redlink=1" class="new" title="Molekular massasi (sahifa yaratilmagan)">Mol. massasi</a></td> <td bgcolor="#eeeeee">345,4 g/mol </td></tr> <tr> <td colspan="2" bgcolor="#dddddd"><b>Farmakokinetik maʼlumot</b> </td></tr> <tr> <td bgcolor="#ddeeff" style="vertical-align: top;"><a href="/w/index.php?title=Biofoydalilik&action=edit&redlink=1" class="new" title="Biofoydalilik (sahifa yaratilmagan)">Biofoydalilik</a></td> <td bgcolor="#eeeeee">35-76% </td></tr> <tr> <td bgcolor="#ddeeff" style="vertical-align: top;"><a href="/wiki/Metabolizm" title="Metabolizm">Metabolizm</a></td> <td bgcolor="#eeeeee">Hepatic (CYP2C19, CYP3A4) </td></tr> <tr> <td bgcolor="#ddeeff" style="vertical-align: top;"><a href="/w/index.php?title=Biologik_yarim_parchalanish&action=edit&redlink=1" class="new" title="Biologik yarim parchalanish (sahifa yaratilmagan)">Yar. parch. davri</a></td> <td bgcolor="#eeeeee">1-1.2 soat </td></tr> <tr> <td bgcolor="#ddeeff" style="vertical-align: top;"><a href="/w/index.php?title=Ekskretsiya&action=edit&redlink=1" class="new" title="Ekskretsiya (sahifa yaratilmagan)">Ekskretsiya</a></td> <td bgcolor="#eeeeee">80% (siydik orqali) <p>20% (safro orqali) </p> </td></tr> <tr> <td colspan="2" bgcolor="#dddddd"><b>Terapevtik tavsiyalar</b> </td></tr> <tr> <td bgcolor="#ddeeff" style="vertical-align: top;"><a href="/w/index.php?title=Homiladorlik_kategoriyasi&action=edit&redlink=1" class="new" title="Homiladorlik kategoriyasi (sahifa yaratilmagan)">Homiladorlik kat.</a> </td> <td bgcolor="#eeeeee"> <p>--- </p> </td></tr> <tr> <td bgcolor="#ddeeff" style="vertical-align: top;"><a href="/w/index.php?title=Dorilar_litsenziyasi&action=edit&redlink=1" class="new" title="Dorilar litsenziyasi (sahifa yaratilmagan)">Qonuniy statusi</a> </td> <td bgcolor="#eeeeee"> <p><a href="/w/index.php?title=Standard_for_the_Uniform_Scheduling_of_Drugs_and_Poisons&action=edit&redlink=1" class="new" title="Standard for the Uniform Scheduling of Drugs and Poisons (sahifa yaratilmagan)">Prescription Only (S4)</a><small>(<a href="/wiki/Avstraliya" title="Avstraliya">AU</a>) </small>GSL<small>(<a href="/wiki/Birlashgan_Qirollik" title="Birlashgan Qirollik">UK</a>) </small>?<small>(<a href="/wiki/AQSh" class="mw-redirect" title="AQSh">US</a>) </small> </p> </td></tr> <tr> <td bgcolor="#ddeeff" style="vertical-align: top;"><a href="/wiki/Dori" title="Dori">Qabul qilish</a> </td> <td bgcolor="#eeeeee">individual </td></tr> </tbody></table> <p>Omeprazol Prilosec, Losec va boshqa brendlari ostida ishlab chiqarilib, gastroezofagial reflyuks kasalligi, oshqozon yara kasalligi va Zollinger-Ellison sindromini davolashda qoʻllanadigan dori vositasi hisoblanadi<sup id="cite_ref-AHFS2015_1-0" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. Bundan tashqari oshqozon ichak traktining yuqori qismlaridan qon ketishini oldini olish uchun ham qoʻllanadi<sup id="cite_ref-AHFS2015_1-1" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. Omeprazol proton-pompa ingibitori (PPI) boʻlib, uning samaradorligi boshqa PPIlarga oʻxshaydi<sup id="cite_ref-TI2016_2-0" class="reference"><a href="#cite_note-TI2016-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>. Ogʻiz orqali yoki tomir ichiga inʼektsiya yoʻli bilan qabul qilish mumkin<sup id="cite_ref-AHFS2015_1-2" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-UK2016_3-0" class="reference"><a href="#cite_note-UK2016-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>. </p><p>Umumiy nojoʻya taʼsirlariga koʻngil aynishi, qusish, bosh ogʻrigʻi, bosh aylanishi, qorin ogʻrigʻi va <a href="/wiki/Ich_dam_bo%CA%BBlishi" title="Ich dam boʻlishi">ichaklarda gaz yig`ilishi</a> kiradi<sup id="cite_ref-AHFS2015_1-3" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Dav2015_4-0" class="reference"><a href="#cite_note-Dav2015-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>. Jiddiy nojoʻya taʼsirlar orasida <a href="/wiki/Zotiljam" title="Zotiljam">pnevmoniya</a> xavfining ortishi, <a href="/wiki/Suyak_sinishi" title="Suyak sinishi">suyak sinishi</a> xavfi va oshqozon saratonini boʻlishi mumkin<sup id="cite_ref-AHFS2015_1-4" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. <a href="/wiki/Homiladorlik" title="Homiladorlik">Homiladorlik paytida</a> qoʻllash boʻyicha yetarli maʼlumot mavjud emas<sup id="cite_ref-AHFS2015_1-5" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. Oshqozon kislotasining ishlab chiqarilishini bloklashi orqali taʼsiri namoyon boʻladi<sup id="cite_ref-AHFS2015_1-6" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. </p><p>Omeprazol 1978-yilda patentlangan va 1988-yilda tibbiy foydalanish uchun tasdiqlangan<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>. U Jahon sogʻliqni saqlash tashkilotining asosiy dorilar roʻyxatiga kiritilgan<sup id="cite_ref-WHO21st_6-0" class="reference"><a href="#cite_note-WHO21st-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>. U umumiy dori sifatida mavjud<sup id="cite_ref-AHFS2015_1-7" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. 2019-yilda u <a href="/wiki/Amerika_Qo%CA%BBshma_Shtatlari" title="Amerika Qoʻshma Shtatlari">Qoʻshma Shtatlarda</a> 52 milliondan ortiq retseptlar bilan eng koʻp buyurilgan dorilar orasida sakkizinchi oʻrinni egallagan<sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>. Amerika Qoʻshma Shtatlarda retseptsiz ham sotib olish mumkin<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Qoʻllanilishi"><span id="Qo.CA.BBllanilishi"></span>Qoʻllanilishi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=1" title="Boʻlimni tahrirlash: Qoʻllanilishi" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=1" title="Edit section's source code: Qoʻllanilishi"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Omeprazol gastroezofagial reflyuks kasalligi , <a href="/wiki/Yara_kasalligi" title="Yara kasalligi">oshqozon yarasi</a>, eroziv ezofagit, Zollinger-Ellison sindromi va eozinofil ezofagitni davolashda qoʻllanadi<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AHFS2015_1-8" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading3"><h3 id="Peptik_yaralarda">Peptik yaralarda</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=2" title="Boʻlimni tahrirlash: Peptik yaralarda" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=2" title="Edit section's source code: Peptik yaralarda"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Oshqozon yarasida omeprazol keng qoʻllanadi. <i>Helicobacteri pylori</i> infektsiyasini davolash 7-14 kun davomida omeprazol, <a href="/wiki/Amoksitsillin" title="Amoksitsillin">amoksitsillin</a> va <a href="/wiki/Klaritromitsin" title="Klaritromitsin">klaritromitsinning</a> uch karrali terapiya kombinatsiyasini qabul qilish orqali amalga oshiriladi<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup>. Agar bemorda amoksitsillinga nisbatan allergiya kuzatilsa, amoksitsillinni metronidazol bilan almashtirish mumkin<sup id="cite_ref-Maastricht_2_Consensus_Report_12-0" class="reference"><a href="#cite_note-Maastricht_2_Consensus_Report-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Nojoʻya_taʻsirlari"><span id="Nojo.CA.BBya_ta.CA.BBsirlari"></span>Nojoʻya taʻsirlari</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=3" title="Boʻlimni tahrirlash: Nojoʻya taʻsirlari" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=3" title="Edit section's source code: Nojoʻya taʻsirlari"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Kamida 1/100 holatda yuzaga keladigan nojoʻya taʼsirlarga quyidagilar kiradi<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup>: </p> <ul><li>Markaziy asab tizimi tomonidan: bosh ogʻrigʻi (7 %), bosh aylanishi (2 %)</li> <li>Nafas olish tizimi tomonidan: <a href="/wiki/O%CA%BBtkir_respirator_kasalliklar" title="Oʻtkir respirator kasalliklar">yuqori nafas yoʻllarining infektsiyasi</a> (2 %), yoʻtal (1 %)</li> <li>Oshqozon-ichak tizimi tomonidan: qorin ogʻrigʻi (5 %), diareya (4 %), koʻngil aynishi (4 %), qusish (3 %), meteorizm (3 %), kislota etishmovchiligi (2 %), ich qotishi (2 %)</li> <li>Nerv-mushak va skelet tizimi tomonidan: bel ogʻrigʻi (1 %), holsizlik (1 %)</li> <li>Dermatologik jihatdan: toshma (2 %)</li></ul> <p>Nojoʻya taʼsirlar bilan bogʻliq boshqa muammolar: </p> <ul><li><i>Clostridium difficile</i> bilan bogʻliq diareyaning takrorlanishi<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Osteoporoz" title="Osteoporoz">Osteoporoz bilan bogʻliq kasalliklar takrorlanishi</a><sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup></li> <li>Gipomagnezemiya<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup></li></ul> <p><a href="/wiki/Vitamin_B12_(Cyanokobalamin)" title="Vitamin B12 (Cyanokobalamin)">Vitamin B <sub>12</sub></a><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> va <a href="/wiki/Temir" title="Temir">temir</a> malabsorbtsiyasi<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> bilan bogʻliq salbiy taʼsir keltirilgan, ammo taʼsirlar ahamiyatsiz boʻlishi mumkin, ayniqsa qoʻshimcha terapiya koʻrsatilganda<sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup>. </p><p>Proton pompa ingibitorlari kashf etilgandan buyon oʻtkir interstitsial nefritning bir nechta holatlari bilan bogʻliq boʻlgan<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Buyrak" title="Buyrak">buyrak</a> yalligʻlanishi koʻpincha PPI larning nojoʻya taʼsiri sifatida qaraladi. </p> <div class="mw-heading mw-heading3"><h3 id="Uzoq_muddatli_foydalanish">Uzoq muddatli foydalanish</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=4" title="Boʻlimni tahrirlash: Uzoq muddatli foydalanish" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=4" title="Edit section's source code: Uzoq muddatli foydalanish"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>PPIlarni uzoq muddat qoʻllash fundal bezlarida yaxshi sifatli poliplarning rivojlanishiga olib kelishi mumkin (bu fundal bez polipozidan farq qiladi); bu poliplar saratonga olib kelmaydi va PPIlar toʻxtatilganda yoʻqoladi. PPI foydalanish va saraton kelib chiqishi oʻrtasida hech qanday bogʻliqlik yoʻq, lekin PPI foydalanish oshqozon saratoni yoki boshqa jiddiy oshqozon muammolari belgilarini yuzaga chiqishini kechiktirishi mumkin va shifokorlar bu taʼsirni bilishlari kerak<sup id="cite_ref-Corleto2014_22-0" class="reference"><a href="#cite_note-Corleto2014-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup>. </p><p>Uzoq muddatli foydalanish va demensiya oʻrtasida bogʻliqlik boʻlishi mumkin, lekin buni tasdiqlash uchun qoʻshimcha oʻrganishlar talab qilinadi<sup id="cite_ref-23" class="reference"><a href="#cite_note-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup>. </p><p>2013-yilda <i>AQSh farmatsevtlarining</i> maqolasida aytilishicha, PPIlarni uzoq muddatli qoʻllash kaltsiyning soʻrilishini pasayishi (<a href="/wiki/Osteoporoz" title="Osteoporoz">osteoporoz</a> va <a href="/wiki/Suyak_sinishi" title="Suyak sinishi">sinish</a> xavfini oshiradi), magniyning soʻrilishini pasayishiga (elektrolitlar buzilishini keltirib chiqaradi) olib keladi. Ularning taxminiga koʻra, bu oshqozon kislotasi ishlab chiqarilishning kamayishi bilan bogʻliq<sup id="cite_ref-24" class="reference"><a href="#cite_note-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading3"><h3 id="Homiladorlik_va_emizish_davrida_qoʻllanishi"><span id="Homiladorlik_va_emizish_davrida_qo.CA.BBllanishi"></span>Homiladorlik va emizish davrida qoʻllanishi</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=5" title="Boʻlimni tahrirlash: Homiladorlik va emizish davrida qoʻllanishi" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=5" title="Edit section's source code: Homiladorlik va emizish davrida qoʻllanishi"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Homilador va emizikli ayollarda omeprazoldan foydalanish xavfsizligi aniqlanmagan<sup id="cite_ref-Dav2015_4-1" class="reference"><a href="#cite_note-Dav2015-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>. Epidemiologik maʼlumotlar ham <a href="/wiki/Homiladorlik" title="Homiladorlik">homiladorlik davrida</a> omeprazolni ona organizmi tomonidan qabul qilingandan keyin jiddiy tugʻma nuqsonlar xavfini koʻrsatmaydi<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup>. </p><p>Hech qanday klinik tadqiqotlar emizishda omeprazolni qoʻllanilgandagi salbiy oqibatlarini tavsiflamaydi. Biroq, omeprazol molekulasining farmakokinetikasi emizishda omeprazoldan foydalanish xavfsizligini tasdiqlaydi. </p> <ul><li>Omeprazolning plazma oqsillari bilan bogʻlanish darajasi yuqori (95 %)<sup id="cite_ref-26" class="reference"><a href="#cite_note-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup>, bu koʻkrak suti hosil boʻlishida preparatning oz miqdori sut kanaliga oʻtishini koʻrsatadi.</li> <li>Omeprazol oshqozonning kislotali sharoitida tez parchalanishi tufayli kapsula bilan qoplangan koʻrinishda qoʻllanishi kerak. Bu shuni koʻrsatadiki, chaqaloq tomonidan qabul qilingan erkin molekulalarning aksariyati soʻrilishidan oldin parchalanadi. </li></ul> <p>Oddiy dozalarda omeprazol emizish davrida xavfsizdir<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Dorilarning_oʻzaro_taʻsiri"><span id="Dorilarning_o.CA.BBzaro_ta.CA.BBsiri"></span>Dorilarning oʻzaro taʻsiri</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=6" title="Boʻlimni tahrirlash: Dorilarning oʻzaro taʻsiri" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=6" title="Edit section's source code: Dorilarning oʻzaro taʻsiri"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="//upload.wikimedia.org/wikipedia/commons/thumb/2/23/Omeprazol_Activis_bottle.jpg/170px-Omeprazol_Activis_bottle.jpg"><img resource="/wiki/Fayl:Omeprazol_Activis_bottle.jpg" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/23/Omeprazol_Activis_bottle.jpg/220px-Omeprazol_Activis_bottle.jpg" decoding="async" width="220" height="294" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/23/Omeprazol_Activis_bottle.jpg/330px-Omeprazol_Activis_bottle.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/23/Omeprazol_Activis_bottle.jpg/440px-Omeprazol_Activis_bottle.jpg 2x" data-file-width="2599" data-file-height="3470" /></a><figcaption> Omeprazol Actavis 20 mg, Shvetsiyada kapsula va tabletkalar koʻrinishida ishlab chiqarilgan</figcaption></figure> <p>Dori vositalarining oʻzaro taʼsiri kam uchraydi<sup id="cite_ref-28" class="reference"><a href="#cite_note-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup>. Shu bilan birga, dorilarning oʻzaro taʼsirining eng muhimi omeprazol bilan birgalikda qabul qilinganda klopidogrelning faollashuvining pasayishi hisoblanadi<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup>. Garchi hali ham bahsli boʻlsa-da<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup>, bu hodisalarning oldini olish uchun klopidogrelni omeprazol bilan birga qoʻllash taqiqlanadi. </p><p>Ular oʻzaro taʼsir qilish mumkin, chunki omeprazol CYP2C19 va CYP3A4 fermentlarining ingibitori hisoblanadi<sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup>. Klopidogrel faol boʻlmagan dori boʻlib, uning faol shakliga oʻtishi qisman CYP2C19 ga bogʻliq. CYP2C19 ning ingibirlanishi klopidogrelning faollashuvini bloklashi mumkin, bu klopidogrelning taʼsirini kamayishiga olib kelishi mumkin<sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup>. </p><p>Deyarli barcha benzodiazepinlar CYP3A4 va CYP2D6 yoʻllari bilan metabollanadi va bu fermentlarning ingibirlanishi benzodiazepinlar metabolizmiga taʼsir koʻrsatadi. Metabolizmi CYP3A4 ga bogʻliq boʻlgan dorilarning boshqa misollari essitalopram, varfarin<sup id="cite_ref-pmid12724615_35-0" class="reference"><a href="#cite_note-pmid12724615-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup>, oksikodon, <a href="/wiki/Tramadol" title="Tramadol">tramadol</a> va oksimorfondir . Agar ular omeprazol bilan bir vaqtda qoʻllanilsa, ushbu dorilarning kontsentratsiyasi oshishi mumkin<sup id="cite_ref-Stedman_36-0" class="reference"><a href="#cite_note-Stedman-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup>. </p><p>Omeprazol, shuningdek, boshqa PPIlar kabi p-glikoproteinning raqobatbardosh ingibitoridir<sup id="cite_ref-37" class="reference"><a href="#cite_note-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup>. </p><p>Oshqozonning kislotali muhitiga bogʻliq boʻlgan dorilar (masalan, ketokonazol yoki atazanavir) yomon soʻriladi, kislotaga chidamli antibiotiklar (masalan, CYP3A4 juda kuchli inhibitori boʻlgan <a href="/wiki/Eritromitsin" title="Eritromitsin">eritromitsin</a>) odatdagidan koʻproq soʻrilishni boshlaydi<sup id="cite_ref-Stedman_36-1" class="reference"><a href="#cite_note-Stedman-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup>. </p><p><i>Hypericum perforatum</i> va <i><a href="/wiki/Ginkgo" title="Ginkgo">Gingko biloba</a></i> CYP3A4 va CYP2C19 induksiyasi orqali omeprazolning plazma kontsentratsiyasini sezilarli darajada kamaytiradi<sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup>. </p><p>Omeprazol kabi proton pompasi ingibitorlari (PPI)metotreksatning plazma kontsentratsiyasini oshirishi aniqlangan<sup id="cite_ref-MD_39-0" class="reference"><a href="#cite_note-MD-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Farmakologik_xususiyatlari">Farmakologik xususiyatlari</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=7" title="Boʻlimni tahrirlash: Farmakologik xususiyatlari" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=7" title="Edit section's source code: Farmakologik xususiyatlari"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Omeprazol oshqozon kislotasi sekretsiyasi uchun zarur boʻlgan parietal hujayralardagi <a href="/wiki/Fermentlar" title="Fermentlar">ferment</a> tizimini bloklaydi. Bu oʻziga xos H +/K + ATFaza ingibirlanishi hisoblanadi. Bu oshqozon kislotasi sekretsiyasining oxirgi bosqichi uchun zarur boʻlgan H atomlarining chiqarilishining bloklanishi hisoblanadi<sup id="cite_ref-:0_40-0" class="reference"><a href="#cite_note-:0-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading3"><h3 id="Farmakodinamikasi">Farmakodinamikasi</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=8" title="Boʻlimni tahrirlash: Farmakodinamikasi" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=8" title="Edit section's source code: Farmakodinamikasi"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Omeprazol selektiv va qaytarilmas proton pompasi ingibitori hisoblanadi. Oshqozon parietal hujayralarining sekretsiya yuzasida joylashgan H <sup>+</sup>/ K <sup>+</sup> -ATfaza tizimini oʻziga xos ingibirlashi orqali oshqozon kislotasi sekretsiyasini kamaytiradi. Ushbu ferment tizimi oshqozon shilliq qavatidagi kislota (proton yoki H <sup>+</sup>) nasosi sifatida qabul qilinganligi sababli, omeprazol kislota ishlab chiqarilishining oxirgi bosqichini ingibirlaydi<sup id="cite_ref-:0_40-1" class="reference"><a href="#cite_note-:0-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup>. </p><p>Omeprazol shuningdek, stimulyatordan qatʼi nazar, bazal va stimulyatsiya qilingan kislota sekretsiyasini ingibirlaydi<sup id="cite_ref-:1_41-0" class="reference"><a href="#cite_note-:1-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup>, chunki u kislota sekretsiyasining oxirgi bosqichini bloklaydi<sup id="cite_ref-:1_41-1" class="reference"><a href="#cite_note-:1-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup>. Omeprazol raqobatdosh boʻlmagan holda bogʻlanadi, shuning uchun u dozaga bogʻliq taʼsir koʻrsatadi<sup id="cite_ref-Omeprazole_42-0" class="reference"><a href="#cite_note-Omeprazole-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup>. Shuning uchun aniq dozalarda qabul qilish buyuriladi. </p><p>Omeprazolning tormozlovchi taʼsiri ogʻiz orqali qabul qilinganidan keyin 1 soat ichida boshlanadi. Maksimal taʼsir 2 soat davom etadi. Tormozlanishning davomiyligi 72 soatgacha. Omeprazol toʻxtatilganda, oshqozon kislotasining asosiy sekretsiya faolligi 3-5 kundan keyin qayta tiklanadi. Omeprazolning kislota sekretsiyasini tormoz qiluvchi taʼsiri kunlik takroriy dozalashdan keyin, 4 kundan keyin pasayadi. </p> <div class="mw-heading mw-heading3"><h3 id="Farmakokinetikasi">Farmakokinetikasi</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=9" title="Boʻlimni tahrirlash: Farmakokinetikasi" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=9" title="Edit section's source code: Farmakokinetikasi"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Omeprazolning soʻrilishi ingichka ichakda sodir boʻladi va odatda 3-6 soat ichida bu jarayon tugaydi. Takroriy dozalardan keyin omeprazolning tizimli biologik mavjudliligi taxminan 60 % ni tashkil qiladi<sup id="cite_ref-43" class="reference"><a href="#cite_note-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup>. Omeprazolning tarqalish hajmi 0,4 l/kg ni tashkil qiladi. U yuqori plazma oqsillari bilan 95 % bogʻlanish qobiliyatiga ega<sup id="cite_ref-Omeprazole_42-1" class="reference"><a href="#cite_note-Omeprazole-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup>. </p><p>Omeprazol, shuningdek, boshqa proton pompa ingibitorlaridan farqli ravishda faqat faol H <sup>+</sup> / K <sup>+</sup> -ATFaza nasoslarida samarali hisoblanadi. Ushbu nasoslar ovqat hazm qilishda yordam berish uchun oziq-ovqat qabul qilingandan soʻng ragʻbatlantiriladi. Shu sababli, bemorlarga omeprazolni och qoringa, bir stakan suv bilan ichish tavsiya qilinadi<sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup>. Bundan tashqari, koʻpgina manbalar omeprazolni qabul qilgandan soʻng, ovqatlanish uchun kamida 30 daqiqa oʻtgan boʻlishi kerakligini yozishadi<sup id="cite_ref-45" class="reference"><a href="#cite_note-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> (zudlik bilan chiqariladigan omeprazol va natriy bikarbonat mahsulotlari, masalan, Zegerid uchun kamida 60 daqiqa)<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup>, Baʼzi manbalarda aytilishicha, omeprazolning kechiktirilgan shakllarida, dori-darmonlarni qabul qilgandan keyin ovqatlanishdan oldin kutish kerak emas. </p><p>Omeprazol sitoxrom P450 tizimi tomonidan, asosan, jigarda, CYP2C19 va CYP3A4 izoenzimlari tomonidan butunlay metabollanadi<sup id="cite_ref-Dav2015_4-2" class="reference"><a href="#cite_note-Dav2015-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup>. Aniqlangan metabolitlar sulfon, sulfid va gidroksi-omeprazol boʻlib, ular kislota sekretsiyasiga sezilarli taʼsir koʻrsatmaydi. Ogʻiz orqali qabul qilingan dozaning taxminan 77 % siydik bilan metabolitlar shaklida organizmdan chiqariladi, qolgan qismi esa najasda, birinchi navbatda, safro sekretsiyasi natijasida organizmdan chiqariladi<sup id="cite_ref-:1_41-2" class="reference"><a href="#cite_note-:1-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup>. Omeprazolning yarim yemirilish davri 0,5 dan 1 soatgacha<sup id="cite_ref-:1_41-3" class="reference"><a href="#cite_note-:1-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup>. Omeprazolning farmakologik taʼsiri uzoqroq davom etadi, chunki u parietal hujayralardagi proton pompasi bilan kovalent bogʻlangan. </p> <div class="mw-heading mw-heading2"><h2 id="Kimyoviy_xossalari">Kimyoviy xossalari</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=10" title="Boʻlimni tahrirlash: Kimyoviy xossalari" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=10" title="Edit section's source code: Kimyoviy xossalari"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Omeprazol piramidali tuzilishda trikoordinatlangan sulfinil oltingugurtni oʻz ichiga oladi va shuning uchun (<i>S</i>) yoki (<i>R</i>) -enantiomerlar sifatida mavjud boʻlishi mumkin. Parietal hujayralar kanallarining kislotali sharoitida ikkala enantiomer ham H / K ATFazadagi sistein guruhi bilan reaksiyaga kirishadigan axiral mahsulotlarga (sulfen kislotasi va sulfenamid konfiguratsiyasi) aylanadi va shu bilan parietal hujayralarning kislota ishlab chiqarish qobiliyatini ingibatsiya qiladi. </p> <dl><dd><span typeof="mw:File"><a href="/wiki/Fayl:Omeprazole_Mechanism_V1.svg" class="mw-file-description" title="Tanadagi omeprazolni qayta tashkil etish"><img alt="Omeprazol rearrangement in the body" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Omeprazole_Mechanism_V1.svg/500px-Omeprazole_Mechanism_V1.svg.png" decoding="async" width="500" height="332" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Omeprazole_Mechanism_V1.svg/750px-Omeprazole_Mechanism_V1.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b7/Omeprazole_Mechanism_V1.svg/1000px-Omeprazole_Mechanism_V1.svg.png 2x" data-file-width="1168" data-file-height="776" /></a></span></dd></dl> <p>AstraZeneca shuningdek, omeprazol kabi optik izomerlarini teng miqdordagi aralashmasi koʻrinishida emas, balki eutomer, sof (<i>S</i>)-enantiomer boʻlgan esomeprazolni (Nexium) ishlab chiqdi . </p> <div class="mw-heading mw-heading3"><h3 id="Tana_suyuqliklarida_oʻlchash"><span id="Tana_suyuqliklarida_o.CA.BBlchash"></span>Tana suyuqliklarida oʻlchash</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=11" title="Boʻlimni tahrirlash: Tana suyuqliklarida oʻlchash" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=11" title="Edit section's source code: Tana suyuqliklarida oʻlchash"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Terapiyani kuzatish yoki kasalxonaga yotqizilgan bemorlarda zaharlanish tashxisini tasdiqlash uchun omeprazolni plazmada aniqlash mumkin. Plazmadagi omeprazol konsentratsiyasi odatda 0,2-1,2 oraligʻida boʻladi. Esomeprazolni optik izomerlarini teng miqdordagi aralashmasidan iborat omeprazoldan ajratish uchun enantiomerik xromatografik usullar mavjud<sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Tarixi">Tarixi</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=12" title="Boʻlimni tahrirlash: Tarixi" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=12" title="Edit section's source code: Tarixi"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Omeprazol birinchi marta 1979-yilda Astra AB tarkibiga kiruvchi shved AB Hässle tomonidan ishlab chiqarilgan. Bu proton pompasi ingibitorlarining (PPI) birinchisi edi<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Fellenius_1981_50-0" class="reference"><a href="#cite_note-Fellenius_1981-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup>. Astra AB, hozirda AstraZeneca, uni Shvetsiyada Losec nomi ostida oshqozon yarasi uchun qoʻllanadigan dori sifatida chiqardi. U birinchi marta AQShda 1989-yilda Losec brendi ostida sotilgan. 1990-yilda AQSh oziq-ovqat va farmatsevtika idorasining iltimosiga koʻra, diuretik Lasix (furosemid) bilan chalkashmaslik uchun Losec brendi Prilosecga oʻzgartirildi<sup id="cite_ref-farley_51-0" class="reference"><a href="#cite_note-farley-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup>. Yangi nom omeprazol (Prilosec) va <a href="/wiki/Antidepressantlar" title="Antidepressantlar">antidepressant</a> boʻlgan fluoksetin (Prozak) oʻrtasidagi chalkashlikka olib keldi<sup id="cite_ref-farley_51-1" class="reference"><a href="#cite_note-farley-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup>. </p><p>2001-yil aprel oyida Prilosec kompaniyasiga tegishli AQSh patentining amal qilish muddati tugagach, AstraZeneca esomeprazolni (Nexium) patentlangan almashtiruvchi dori sifatida taqdim etdi<sup id="cite_ref-52" class="reference"><a href="#cite_note-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup>. AstraZeneca patentlarining butun dunyo boʻylab muddati tugagani sababli koʻplab kompaniyalar jineriklarni taqdim etdilar, ular hozirda koʻplab brend nomlari ostida mavjud. Misol uchun Omez. </p> <div class="mw-heading mw-heading2"><h2 id="Chiqarilish_shakli">Chiqarilish shakli</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=13" title="Boʻlimni tahrirlash: Chiqarilish shakli" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=13" title="Edit section's source code: Chiqarilish shakli"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Dozalash_shakllari">Dozalash shakllari</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=14" title="Boʻlimni tahrirlash: Dozalash shakllari" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=14" title="Edit section's source code: Dozalash shakllari"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Omeprazole_10mg_UK.jpg/220px-Omeprazole_10mg_UK.jpg"><img resource="/wiki/Fayl:Omeprazole_10mg_UK.jpg" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Omeprazole_10mg_UK.jpg/220px-Omeprazole_10mg_UK.jpg" decoding="async" width="220" height="165" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/13/Omeprazole_10mg_UK.jpg/330px-Omeprazole_10mg_UK.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/13/Omeprazole_10mg_UK.jpg/440px-Omeprazole_10mg_UK.jpg 2x" data-file-width="2048" data-file-height="1536" /></a><figcaption> Omeprazol 10 mg, Buyuk Britaniya mahsuloti.</figcaption></figure> <p>Uni ogʻiz orqali, kapsula, tabletka yoki suspenziya shaklida yoki tomir ichiga yuborish orqali qabul qilish mumkin<sup id="cite_ref-AHFS2015_1-9" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-UK2016_3-1" class="reference"><a href="#cite_note-UK2016-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>. </p><p>Omeprazol 10, 20, 40 va baʼzi davlatlarda 80 mg kuchli dozalarda mavjud. Ogʻiz orqali qabul qilinadigan omeprazol preparatlarining aksariyati kapsula bilan qoplangan, sababi oshqozonning kislotali sharoitida preparatning tez parchalanishi tufayli. </p><p>U shuningdek, Yevropada (IV) inʼektsiya shaklida qoʻllanadi, ammo AQShda inʼektsiya shakli ishlatilmaydi. Har 10 ml shaffof shisha flakonda omeprazol natriy 42,6 dan iborat oppoq ranggacha liyofillangan kukun koʻrinishida mavjud. </p><p>Omeprazol, shuningdek, litsenziyasiz mahsulot sifatida Buyuk Britaniyada kapsula bilan qoplangan dori shakli va ichish uchun suspenziyasi sifatida ham mavjud. Ichish uchun suspenziyalari asosan bolalar uchun qoʻllanadi, lekin yutishi qiyin boʻlganlar yoki oziqlantirish naychasidan foydalanadiganlar tomonidan ham qoʻllanishi mumkin. </p> <div class="mw-heading mw-heading3"><h3 id="Brend_nomlari">Brend nomlari</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=15" title="Boʻlimni tahrirlash: Brend nomlari" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=15" title="Edit section's source code: Brend nomlari"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Tovar nomlariga Losec, Prilosec, Zegerid, Miracid, Omepraks, Kamezo va Omez kiradi<sup id="cite_ref-Drugs.com_international_53-0" class="reference"><a href="#cite_note-Drugs.com_international-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-AHFS2015_1-10" class="reference"><a href="#cite_note-AHFS2015-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>. </p> <div class="mw-heading mw-heading2"><h2 id="Manbalar">Manbalar</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Omeprazol&veaction=edit&section=16" title="Boʻlimni tahrirlash: Manbalar" class="mw-editsection-visualeditor"><span>tahrir</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Omeprazol&action=edit&section=16" title="Edit section's source code: Manbalar"><span>manbasini tahrirlash</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r3605845">.mw-parser-output .reflist{font-size:90%;margin-bottom:0.5em;list-style-type:decimal}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-AHFS2015-1"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-AHFS2015_1-0">1,00</a></sup> <sup><a href="#cite_ref-AHFS2015_1-1">1,01</a></sup> <sup><a href="#cite_ref-AHFS2015_1-2">1,02</a></sup> <sup><a href="#cite_ref-AHFS2015_1-3">1,03</a></sup> <sup><a href="#cite_ref-AHFS2015_1-4">1,04</a></sup> <sup><a href="#cite_ref-AHFS2015_1-5">1,05</a></sup> <sup><a href="#cite_ref-AHFS2015_1-6">1,06</a></sup> <sup><a href="#cite_ref-AHFS2015_1-7">1,07</a></sup> <sup><a href="#cite_ref-AHFS2015_1-8">1,08</a></sup> <sup><a href="#cite_ref-AHFS2015_1-9">1,09</a></sup> <sup><a href="#cite_ref-AHFS2015_1-10">1,10</a></sup></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/omeprazole.html">„Omeprazole“</a></span>.  The American Society of Health-System Pharmacists. 2011-yil 19-fevralda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110219135631/http://www.drugs.com/monograph/omeprazole.html">arxivlangan</a>. Qaraldi: 2018-yil 21-oktyabr.</span></span></span> </li> <li id="cite_note-TI2016-2"><span class="mw-cite-backlink"><a href="#cite_ref-TI2016_2-0">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://www.ti.ubc.ca/2016/06/28/99-comparative-effectiveness-proton-pump-inhibitors/">„[99</a> Comparative effectiveness of proton pump inhibitors | Therapeutics Initiative“]</span> (2016-yil 28-iyun). 2020-yil 30-oktyabrda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20201030063031/https://www.ti.ubc.ca/2016/06/28/99-comparative-effectiveness-proton-pump-inhibitors/">arxivlangan</a>. Qaraldi: 2016-yil 14-iyul.</span></span></span> </li> <li id="cite_note-UK2016-3"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-UK2016_3-0">3,0</a></sup> <sup><a href="#cite_ref-UK2016_3-1">3,1</a></sup></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://www.medicines.org.uk/emc/medicine/25259">„Omeprazole 40 mg Powder for Solution for Infusion“</a></span>. <i>EMC</i> (2016-yil 10-fevral). 2016-yil 7-aprelda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160407193540/https://www.medicines.org.uk/emc/medicine/25259">arxivlangan</a>. Qaraldi: 2018-yil 21-oktyabr.</span></span></span> </li> <li id="cite_note-Dav2015-4"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Dav2015_4-0">4,0</a></sup> <sup><a href="#cite_ref-Dav2015_4-1">4,1</a></sup> <sup><a href="#cite_ref-Dav2015_4-2">4,2</a></sup></span> <span class="reference-text"><span class="citation" id="CITEREFVallerand2015">Vallerand, A.H.<i>. <a rel="nofollow" class="external text" href="https://archive.org/details/davissdrugguidef0000vall_n3r2">Davis's Drug Guide for Nurses</a></i>, 14th, F.A. Davis Company, 2015 — <a rel="nofollow" class="external text" href="https://archive.org/details/davissdrugguidef0000vall_n3r2/page/924">924</a>–925-bet. <a href="/wiki/Maxsus:BookSources/978-0-8036-4085-6" title="Maxsus:BookSources/978-0-8036-4085-6">ISBN <span style="white-space: nowrap;">978-0-8036-4085-6</span></a>. <a href="https://en.wikipedia.org/wiki/OCLC" class="extiw" title="en:OCLC">OCLC</a> <a rel="nofollow" class="external text" href="http://worldcat.org/oclc/881473728">881473728</a>.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Davis%27s+Drug+Guide+for+Nurses&rft.aulast=Vallerand&rft.aufirst=A.H.&rft.edition=14th&rft.pub=F.A.+Davis+Company&rft.pages=%5Bhttps%3A%2F%2Farchive.org%2Fdetails%2Fdavissdrugguidef0000vall_n3r2%2Fpage%2F924+924%5D%E2%80%93925 &rft.isbn=978-0-8036-4085-6&rft_id=info:oclcnum/881473728&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fdavissdrugguidef0000vall_n3r2"> </span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text"><span class="citation" id="CITEREFFischer2006">Fischer, Jnos<i>. <a rel="nofollow" class="external text" href="https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA445">Analogue-based Drug Discovery</a></i> (en). John Wiley & Sons, 2006 — 445-bet. <a href="/wiki/Maxsus:BookSources/9783527607495" title="Maxsus:BookSources/9783527607495">ISBN <span style="white-space: nowrap;">9783527607495</span></a>. Qaraldi: 2020-yil 29-iyun.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Analogue-based+Drug+Discovery&rft.aulast=Fischer&rft.aufirst=Jnos&rft.date=2006&rft.pub=John+Wiley+%26+Sons&rft.pages=445 &rft.isbn=9783527607495&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DFjKfqkaKkAAC%26pg%3DPA445"> </span></span> </li> <li id="cite_note-WHO21st-6"><span class="mw-cite-backlink"><a href="#cite_ref-WHO21st_6-0">↑</a></span> <span class="reference-text"><span class="citation"><i>. World Health Organization model list of essential medicines: 21st list 2019</i>. Geneva: World Health Organization, 2019. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.</span><span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=World+Health+Organization+model+list+of+essential+medicines%3A+21st+list+2019&rft.pub=World+Health+Organization&rft.place=Geneva"> </span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><a href="#cite_ref-7">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Top300Drugs.aspx">„The Top 300 of 2019“</a></span>. <i>ClinCalc</i>. 2020-yil 18-martda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200318234059/https://clincalc.com/DrugStats/Top300Drugs.aspx">arxivlangan</a>. Qaraldi: 2021-yil 16-oktyabr.</span></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><a href="#cite_ref-8">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Drugs/Omeprazole">„Omeprazole - Drug Usage Statistics, ClinCalc DrugStats Database“</a></span>. <i>ClinCalc</i>. 2020-yil 28-fevralda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200228060553/https://clincalc.com/DrugStats/Drugs/Omeprazole">arxivlangan</a>. Qaraldi: 2021-yil 16-oktyabr.</span></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><i>Research.</i> <span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/questions-and-answers-prilosec-otc-omeprazole">„Questions and Answers on Prilosec OTC (omeprazole)“</a></span>. <i>U.S. <a href="/w/index.php?title=Food_and_Drug_Administration&action=edit&redlink=1" class="new" title="Food and Drug Administration (sahifa yaratilmagan)">Food and Drug Administration</a> (FDA)</i> (2018-yil 3-noyabr). 2021-yil 28-avgustda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210828195503/https://www.fda.gov/about-fda/center-drug-evaluation-and-research-cder/questions-and-answers-prilosec-otc-omeprazole">arxivlangan</a>. Qaraldi: 2020-yil 2-mart.</span></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><a href="#cite_ref-10">↑</a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r5263675">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:linear-gradient(transparent,transparent),url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#3a3;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><cite id="CITEREFCheng2013" class="citation magazine cs1">Cheng, Edaire (21 July 2013). „Proton Pump Inhibitors for Eosinophilic Esophagitis“. <i>Current Opinion in Gastroenterology</i>. 29-jild, № 4. 416–420-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FMOG.0b013e32835fb50e">10.1097/MOG.0b013e32835fb50e</a>. <a href="/wiki/ISSN" class="mw-redirect" title="ISSN">ISSN</a> <a rel="nofollow" class="external text" href="//www.worldcat.org/issn/0267-1379">0267-1379</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC4118554">4118554</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23449027">23449027</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Opinion+in+Gastroenterology&rft.atitle=Proton+Pump+Inhibitors+for+Eosinophilic+Esophagitis&rft.volume=29&rft.issue=4&rft.pages=416-420&rft.date=2013-07-21&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4118554%23id-name%3DPMC&rft.issn=0267-1379&rft_id=info%3Apmid%2F23449027&rft_id=info%3Adoi%2F10.1097%2FMOG.0b013e32835fb50e&rft.aulast=Cheng&rft.aufirst=Edaire&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><a href="#cite_ref-11">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFFuccioMinardiZagariGrilli2007" class="citation magazine cs1">Fuccio, Lorenzo; Minardi, Maria Eugenia; Zagari, Rocco Maurizo; Grilli, Diego; Magrini, Nicola; Bazzoli, Franco (2007). „Meta-analysis: Duration of First-Line Proton-Pump Inhibitor–Based Triple Therapy for <i>Helicobacter pylori</i> Eradication“. <i>Annals of Internal Medicine</i>. 147-jild, № 8. 553–62-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.7326%2F0003-4819-147-8-200710160-00008">10.7326/0003-4819-147-8-200710160-00008</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17938394">17938394</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Annals+of+Internal+Medicine&rft.atitle=Meta-analysis%3A+Duration+of+First-Line+Proton-Pump+Inhibitor%E2%80%93Based+Triple+Therapy+for+Helicobacter+pylori+Eradication&rft.volume=147&rft.issue=8&rft.pages=553-62&rft.date=2007&rft_id=info%3Adoi%2F10.7326%2F0003-4819-147-8-200710160-00008&rft_id=info%3Apmid%2F17938394&rft.aulast=Fuccio&rft.aufirst=Lorenzo&rft.au=Minardi%2C+Maria+Eugenia&rft.au=Zagari%2C+Rocco+Maurizo&rft.au=Grilli%2C+Diego&rft.au=Magrini%2C+Nicola&rft.au=Bazzoli%2C+Franco&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-Maastricht_2_Consensus_Report-12"><span class="mw-cite-backlink"><a href="#cite_ref-Maastricht_2_Consensus_Report_12-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite class="citation magazine cs1">„Current concepts in the management of <i>Helicobacter pylori</i> infection: the Maastricht III Consensus Report“. <i>Gut</i>. 56-jild, № 6. 21 June 2007. 772–81-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fgut.2006.101634">10.1136/gut.2006.101634</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC1954853">1954853</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17170018">17170018</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Current+concepts+in+the+management+of+Helicobacter+pylori+infection%3A+the+Maastricht+III+Consensus+Report&rft.volume=56&rft.issue=6&rft.pages=772-81&rft.date=2007-06-21&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1954853%23id-name%3DPMC&rft_id=info%3Apmid%2F17170018&rft_id=info%3Adoi%2F10.1136%2Fgut.2006.101634&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><a href="#cite_ref-13">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite class="citation magazine cs1">„Omeprazole. An updated review of its pharmacology and therapeutic use in acid-related disorders“. <i>Drugs</i>. 42-jild, № 1. 1991. 138–70-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F00003495-199142010-00008">10.2165/00003495-199142010-00008</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/1718683">1718683</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Omeprazole.+An+updated+review+of+its+pharmacology+and+therapeutic+use+in+acid-related+disorders&rft.volume=42&rft.issue=1&rft.pages=138-70&rft.date=1991&rft_id=info%3Adoi%2F10.2165%2F00003495-199142010-00008&rft_id=info%3Apmid%2F1718683&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><a href="#cite_ref-14">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFAbou_Chakra2014" class="citation magazine cs1">Abou Chakra, CN; et al. (21 June 2014). „Risk factors for recurrence, complications and mortality in Clostridium difficile infection: a systematic review“. <i>PLOS ONE</i>. 9-jild, № 6. e98400-bet. <a href="/w/index.php?title=Bibcode&action=edit&redlink=1" class="new" title="Bibcode (sahifa yaratilmagan)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2014PLoSO...998400A">2014PLoSO...998400A</a>. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pone.0098400">10.1371/journal.pone.0098400</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC4045753">4045753</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/24897375">24897375</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+ONE&rft.atitle=Risk+factors+for+recurrence%2C+complications+and+mortality+in+Clostridium+difficile+infection%3A+a+systematic+review&rft.volume=9&rft.issue=6&rft.pages=e98400&rft.date=2014-06-21&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4045753%23id-name%3DPMC&rft_id=info%3Apmid%2F24897375&rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0098400&rft_id=info%3Abibcode%2F2014PLoSO...998400A&rft.aulast=Abou+Chakra&rft.aufirst=CN&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><a href="#cite_ref-15">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFYang2006" class="citation magazine cs1">Yang, Yu-Xiao; et al. (2006). „Long-term proton pump inhibitor therapy and risk of hip fracture“. <i>JAMA</i>. 296-jild, № 24. 2947–2953-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjama.296.24.2947">10.1001/jama.296.24.2947</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17190895">17190895</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Long-term+proton+pump+inhibitor+therapy+and+risk+of+hip+fracture&rft.volume=296&rft.issue=24&rft.pages=2947-2953&rft.date=2006&rft_id=info%3Adoi%2F10.1001%2Fjama.296.24.2947&rft_id=info%3Apmid%2F17190895&rft.aulast=Yang&rft.aufirst=Yu-Xiao&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><a href="#cite_ref-16">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFYu2011" class="citation magazine cs1">Yu, Elaine W.; et al. (2011). „Proton pump inhibitors and risk of fractures: a meta-analysis of 11 international studies“. <i>The American Journal of Medicine</i>. 124-jild, № 6. 519–526-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.amjmed.2011.01.007">10.1016/j.amjmed.2011.01.007</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3101476">3101476</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/21605729">21605729</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Medicine&rft.atitle=Proton+pump+inhibitors+and+risk+of+fractures%3A+a+meta-analysis+of+11+international+studies&rft.volume=124&rft.issue=6&rft.pages=519-526&rft.date=2011&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3101476%23id-name%3DPMC&rft_id=info%3Apmid%2F21605729&rft_id=info%3Adoi%2F10.1016%2Fj.amjmed.2011.01.007&rft.aulast=Yu&rft.aufirst=Elaine+W.&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><a href="#cite_ref-17">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFHess2012" class="citation magazine cs1">Hess, M. W.; et al. (2012). „Systematic review: hypomagnesaemia induced by proton pump inhibition“. <i>Alimentary Pharmacology & Therapeutics</i>. 36-jild, № 5. 405–413-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2036.2012.05201.x">10.1111/j.1365-2036.2012.05201.x</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22762246">22762246</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Alimentary+Pharmacology+%26+Therapeutics&rft.atitle=Systematic+review%3A+hypomagnesaemia+induced+by+proton+pump+inhibition&rft.volume=36&rft.issue=5&rft.pages=405-413&rft.date=2012&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2036.2012.05201.x&rft_id=info%3Apmid%2F22762246&rft.aulast=Hess&rft.aufirst=M.+W.&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><a href="#cite_ref-18">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFNealLogan2001" class="citation magazine cs1">Neal, Keith; Logan, Richard (2001). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_alimentary-pharmacology-and-therapeutics_2001-07_15_7/page/1085">„Potential gastrointestinal effects of long‐term acid suppression with proton pump inhibitors“</a>. <i>Alimentary Pharmacology & Therapeutics</i>. 15-jild, № 7. 1085–6-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1365-2036.2001.0994a.x">10.1046/j.1365-2036.2001.0994a.x</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/11421886">11421886</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Alimentary+Pharmacology+%26+Therapeutics&rft.atitle=Potential+gastrointestinal+effects+of+long%E2%80%90term+acid+suppression+with+proton+pump+inhibitors&rft.volume=15&rft.issue=7&rft.pages=1085-6&rft.date=2001&rft_id=info%3Adoi%2F10.1046%2Fj.1365-2036.2001.0994a.x&rft_id=info%3Apmid%2F11421886&rft.aulast=Neal&rft.aufirst=Keith&rft.au=Logan%2C+Richard&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_alimentary-pharmacology-and-therapeutics_2001-07_15_7%2Fpage%2F1085&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><a href="#cite_ref-19">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFSarzynski2011" class="citation magazine cs1">Sarzynski, Erin; et al. (2011). <a rel="nofollow" class="external text" href="https://archive.org/details/sim_digestive-diseases-and-sciences_2011-08_56_8/page/2349">„Association between proton pump inhibitor use and anemia: a retrospective cohort study“</a>. <i>Digestive Diseases and Sciences</i>. 56-jild, № 8. 2349–2353-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10620-011-1589-y">10.1007/s10620-011-1589-y</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/21318590">21318590</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Digestive+Diseases+and+Sciences&rft.atitle=Association+between+proton+pump+inhibitor+use+and+anemia%3A+a+retrospective+cohort+study&rft.volume=56&rft.issue=8&rft.pages=2349-2353&rft.date=2011&rft_id=info%3Adoi%2F10.1007%2Fs10620-011-1589-y&rft_id=info%3Apmid%2F21318590&rft.aulast=Sarzynski&rft.aufirst=Erin&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_digestive-diseases-and-sciences_2011-08_56_8%2Fpage%2F2349&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><a href="#cite_ref-20">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFMcColl2009" class="citation magazine cs1">McColl, Kenneth EL (2009). „Effect of proton pump inhibitors on vitamins and iron“. <i>The American Journal of Gastroenterology</i>. 104-jild. S5–S9-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fajg.2009.45">10.1038/ajg.2009.45</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/19262546">19262546</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Gastroenterology&rft.atitle=Effect+of+proton+pump+inhibitors+on+vitamins+and+iron&rft.volume=104&rft.pages=S5-S9&rft.date=2009&rft_id=info%3Adoi%2F10.1038%2Fajg.2009.45&rft_id=info%3Apmid%2F19262546&rft.aulast=McColl&rft.aufirst=Kenneth+EL&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-21"><span class="mw-cite-backlink"><a href="#cite_ref-21">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFHärmark2007" class="citation magazine cs1">Härmark, Linda; et al. (2007). „Proton pump inhibitor‐induced acute interstitial nephritis“. <i>British Journal of Clinical Pharmacology</i>. 64-jild, № 6. 819–823-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2125.2007.02927.x">10.1111/j.1365-2125.2007.02927.x</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2198775">2198775</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/17635502">17635502</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=British+Journal+of+Clinical+Pharmacology&rft.atitle=Proton+pump+inhibitor%E2%80%90induced+acute+interstitial+nephritis&rft.volume=64&rft.issue=6&rft.pages=819-823&rft.date=2007&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2198775%23id-name%3DPMC&rft_id=info%3Apmid%2F17635502&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2125.2007.02927.x&rft.aulast=H%C3%A4rmark&rft.aufirst=Linda&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-Corleto2014-22"><span class="mw-cite-backlink"><a href="#cite_ref-Corleto2014_22-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFCorleto,_V.D.2014" class="citation magazine cs1">Corleto, V.D. (21 February 2014). „Proton pump inhibitor therapy and potential long-term harm“. <i>Curr Opin Endocrinol Diabetes Obes</i>. 21-jild, № 1. 3–8-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2Fmed.0000000000000031">10.1097/med.0000000000000031</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/24310148">24310148</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Curr+Opin+Endocrinol+Diabetes+Obes&rft.atitle=Proton+pump+inhibitor+therapy+and+potential+long-term+harm.&rft.volume=21&rft.issue=1&rft.pages=3-8&rft.date=2014-02-21&rft_id=info%3Adoi%2F10.1097%2Fmed.0000000000000031&rft_id=info%3Apmid%2F24310148&rft.au=Corleto%2C+V.D.&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-23"><span class="mw-cite-backlink"><a href="#cite_ref-23">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFEusebiRabittiArtesianiGelli2017" class="citation magazine cs1">Eusebi, LH; Rabitti, S; Artesiani, ML; Gelli, D; Montagnani, M; Zagari, RM; Bazzoli, F (21 July 2017). „Proton pump inhibitors: Risks of long-term use“. <i>Journal of Gastroenterology and Hepatology</i>. 32-jild, № 7. 1295–1302-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fjgh.13737">10.1111/jgh.13737</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/28092694">28092694</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Gastroenterology+and+Hepatology&rft.atitle=Proton+pump+inhibitors%3A+Risks+of+long-term+use.&rft.volume=32&rft.issue=7&rft.pages=1295-1302&rft.date=2017-07-21&rft_id=info%3Adoi%2F10.1111%2Fjgh.13737&rft_id=info%3Apmid%2F28092694&rft.aulast=Eusebi&rft.aufirst=LH&rft.au=Rabitti%2C+S&rft.au=Artesiani%2C+ML&rft.au=Gelli%2C+D&rft.au=Montagnani%2C+M&rft.au=Zagari%2C+RM&rft.au=Bazzoli%2C+F&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-24"><span class="mw-cite-backlink"><a href="#cite_ref-24">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><i>Georgia.</i> <span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://www.uspharmacist.com/article/longterm-consequences-of-chronic-proton-pump-inhibitor-use">„Long-Term Consequences of Chronic Proton Pump Inhibitor Use“</a></span> (en). <i>www.uspharmacist.com</i>. 2021-yil 21-yanvarda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210121163435/https://www.uspharmacist.com/article/longterm-consequences-of-chronic-proton-pump-inhibitor-use">arxivlangan</a>. Qaraldi: 2020-yil 28-dekabr.</span></span></span> </li> <li id="cite_note-25"><span class="mw-cite-backlink"><a href="#cite_ref-25">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFPasternakHviid2010" class="citation magazine cs1">Pasternak, Björn; Hviid, Anders (2010). „Use of Proton-Pump Inhibitors in Early Pregnancy and the Risk of Birth Defects“. <i>New England Journal of Medicine</i>. 363-jild, № 22. 2114–23-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMoa1002689">10.1056/NEJMoa1002689</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/21105793">21105793</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=New+England+Journal+of+Medicine&rft.atitle=Use+of+Proton-Pump+Inhibitors+in+Early+Pregnancy+and+the+Risk+of+Birth+Defects&rft.volume=363&rft.issue=22&rft.pages=2114-23&rft.date=2010&rft_id=info%3Adoi%2F10.1056%2FNEJMoa1002689&rft_id=info%3Apmid%2F21105793&rft.aulast=Pasternak&rft.aufirst=Bj%C3%B6rn&rft.au=Hviid%2C+Anders&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-26"><span class="mw-cite-backlink"><a href="#cite_ref-26">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://www.pdr.net/drug-summary/prilosec-delayed-release-capsules-and-oral-suspension?druglabelid=1123">„Omeprazole drug summary“</a></span>.  PDR.net. 2014-yil 3-martda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140303163837/http://www.pdr.net/drug-summary/prilosec-delayed-release-capsules-and-oral-suspension?druglabelid=1123">arxivlangan</a>. Qaraldi: 2018-yil 21-oktyabr.</span></span></span> </li> <li id="cite_note-27"><span class="mw-cite-backlink"><a href="#cite_ref-27">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+lactmed:@term+@rel+@rn+73590-58-6">„LACTMED: OMEPRAZOLE“</a></span> (2015-yil 10-mart). 2017-yil 8-sentyabrda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908170635/https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+lactmed%253A%2540term+%2540rel+%2540rn+73590-58-6">arxivlangan</a>. Qaraldi: 2018-yil 21-oktyabr.</span></span></span> </li> <li id="cite_note-28"><span class="mw-cite-backlink"><a href="#cite_ref-28">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><i>Fitzakerley.</i> <span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://www.d.umn.edu/~jfitzake/Lectures/DMED/Antiulcer/Treatment/ReducePain/PPIs/PPIsSE.html">„2014 Treatments for Acid-Peptic Diseases.“</a></span>.  University of Minnesota Medical School Duluth. 2014-yil 19-aprelda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20140419014436/http://www.d.umn.edu/~jfitzake/Lectures/DMED/Antiulcer/Treatment/ReducePain/PPIs/PPIsSE.html">arxivlangan</a>. Qaraldi: 2018-yil 21-oktyabr.</span></span></span> </li> <li id="cite_note-29"><span class="mw-cite-backlink"><a href="#cite_ref-29">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://www.cms.gov/Medicare-Medicaid-Coordination/Fraud-Prevention/Medicaid-Integrity-Education/Pharmacy-Education-Materials/Downloads/ppi-adult-factsheet.pdf">„Proton Pump Inhibitor: Use in Adults“</a></span>. <i>CMS Medicaid Integrity Program</i>. 2013-yil 12-dekabrda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20131212143828/http://www.cms.gov/Medicare-Medicaid-Coordination/Fraud-Prevention/Medicaid-Integrity-Education/Pharmacy-Education-Materials/Downloads/ppi-adult-factsheet.pdf">arxivlangan</a>. Qaraldi: 2018-yil 21-oktyabr.</span></span></span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><a href="#cite_ref-30">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFDouglasEvansHingoraniGrosso2012" class="citation magazine cs1">Douglas, I. J.; Evans, S. J.; Hingorani, A. D.; Grosso, A. M.; Timmis, A; Hemingway, H; Smeeth, L (2012). „Clopidogrel and interaction with proton pump inhibitors: comparison between cohort and within person study designs“. <i>BMJ</i>. 345-jild. e4388-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fbmj.e4388">10.1136/bmj.e4388</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3392956">3392956</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22782731">22782731</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=BMJ&rft.atitle=Clopidogrel+and+interaction+with+proton+pump+inhibitors%3A+comparison+between+cohort+and+within+person+study+designs&rft.volume=345&rft.pages=e4388&rft.date=2012&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3392956%23id-name%3DPMC&rft_id=info%3Apmid%2F22782731&rft_id=info%3Adoi%2F10.1136%2Fbmj.e4388&rft.aulast=Douglas&rft.aufirst=I.+J.&rft.au=Evans%2C+S.+J.&rft.au=Hingorani%2C+A.+D.&rft.au=Grosso%2C+A.+M.&rft.au=Timmis%2C+A&rft.au=Hemingway%2C+H&rft.au=Smeeth%2C+L&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-31"><span class="mw-cite-backlink"><a href="#cite_ref-31">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFFocksBrouwerVan_OijenLanas2012" class="citation magazine cs1">Focks, J. J.; Brouwer, M. A.; Van Oijen, M. G. H.; Lanas, A.; Bhatt, D. L.; Verheugt, F. W. A. (2012). „Concomitant use of clopidogrel and proton pump inhibitors: Impact on platelet function and clinical outcome- a systematic review“. <i>Heart</i>. 99-jild, № 8. 520–7-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fheartjnl-2012-302371">10.1136/heartjnl-2012-302371</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/22851683">22851683</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Heart&rft.atitle=Concomitant+use+of+clopidogrel+and+proton+pump+inhibitors%3A+Impact+on+platelet+function+and+clinical+outcome-+a+systematic+review&rft.volume=99&rft.issue=8&rft.pages=520-7&rft.date=2012&rft_id=info%3Adoi%2F10.1136%2Fheartjnl-2012-302371&rft_id=info%3Apmid%2F22851683&rft.aulast=Focks&rft.aufirst=J.+J.&rft.au=Brouwer%2C+M.+A.&rft.au=Van+Oijen%2C+M.+G.+H.&rft.au=Lanas%2C+A.&rft.au=Bhatt%2C+D.+L.&rft.au=Verheugt%2C+F.+W.+A.&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-32"><span class="mw-cite-backlink"><a href="#cite_ref-32">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFShirasakaSagerLutzDavis2013" class="citation magazine cs1">Shirasaka, Y; Sager, J. E.; Lutz, J. D.; Davis, C; Isoherranen, N (July 2013). „Inhibition of CYP2C19 and CYP3A4 by Omeprazole Metabolites and Their Contribution to Drug-Drug Interactions“. <i>Drug Metab. Dispos</i>. 41-jild, № 7. 1414–24-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1124%2Fdmd.113.051722">10.1124/dmd.113.051722</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC3684819">3684819</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23620487">23620487</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Metab.+Dispos.&rft.atitle=Inhibition+of+CYP2C19+and+CYP3A4+by+Omeprazole+Metabolites+and+Their+Contribution+to+Drug-Drug+Interactions&rft.volume=41&rft.issue=7&rft.pages=1414-24&rft.date=2013-07&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3684819%23id-name%3DPMC&rft_id=info%3Apmid%2F23620487&rft_id=info%3Adoi%2F10.1124%2Fdmd.113.051722&rft.aulast=Shirasaka&rft.aufirst=Y&rft.au=Sager%2C+J.+E.&rft.au=Lutz%2C+J.+D.&rft.au=Davis%2C+C&rft.au=Isoherranen%2C+N&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-33"><span class="mw-cite-backlink"><a href="#cite_ref-33">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite class="citation magazine cs1">„The drug-drug interaction between proton pump inhibitors and clopidogrel“. <i>CMAJ</i>. 180-jild, № 7. March 2009. 699–700-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1503%2Fcmaj.090251">10.1503/cmaj.090251</a>. <a href="/w/index.php?title=PMC&action=edit&redlink=1" class="new" title="PMC (sahifa yaratilmagan)">PMC</a> <span class="cs1-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="//www.ncbi.nlm.nih.gov/pmc/articles/PMC2659824">2659824</a></span>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/19332744">19332744</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=CMAJ&rft.atitle=The+drug-drug+interaction+between+proton+pump+inhibitors+and+clopidogrel&rft.volume=180&rft.issue=7&rft.pages=699-700&rft.date=2009-03&rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2659824%23id-name%3DPMC&rft_id=info%3Apmid%2F19332744&rft_id=info%3Adoi%2F10.1503%2Fcmaj.090251&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-34"><span class="mw-cite-backlink"><a href="#cite_ref-34">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite class="citation magazine cs1">„Drug-drug interaction between clopidogrel and the proton pump inhibitors“. <i>Ann Pharmacother</i>. 43-jild, № 7. July 2009. 1266–1274-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1345%2Faph.1M051">10.1345/aph.1M051</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/19470853">19470853</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Ann+Pharmacother&rft.atitle=Drug-drug+interaction+between+clopidogrel+and+the+proton+pump+inhibitors&rft.volume=43&rft.issue=7&rft.pages=1266-1274&rft.date=2009-07&rft_id=info%3Adoi%2F10.1345%2Faph.1M051&rft_id=info%3Apmid%2F19470853&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-pmid12724615-35"><span class="mw-cite-backlink"><a href="#cite_ref-pmid12724615_35-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite class="citation magazine cs1">„Pharmacogenetics of oral anticoagulants“. <i>Pharmacogenetics</i>. 13-jild, № 5. May 2003. 247–52-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2F00008571-200305000-00002">10.1097/00008571-200305000-00002</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/12724615">12724615</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Pharmacogenetics&rft.atitle=Pharmacogenetics+of+oral+anticoagulants&rft.volume=13&rft.issue=5&rft.pages=247-52&rft.date=2003-05&rft_id=info%3Adoi%2F10.1097%2F00008571-200305000-00002&rft_id=info%3Apmid%2F12724615&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-Stedman-36"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Stedman_36-0">36,0</a></sup> <sup><a href="#cite_ref-Stedman_36-1">36,1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite class="citation magazine cs1">„Review article: comparison of the pharmacokinetics, acid suppression and efficacy of proton pump inhibitors“. <i>Aliment Pharmacol Ther</i>. 14-jild, № 8. August 2000. 963–978-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1365-2036.2000.00788.x">10.1046/j.1365-2036.2000.00788.x</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/10930890">10930890</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Aliment+Pharmacol+Ther&rft.atitle=Review+article%3A+comparison+of+the+pharmacokinetics%2C+acid+suppression+and+efficacy+of+proton+pump+inhibitors&rft.volume=14&rft.issue=8&rft.pages=963-978&rft.date=2000-08&rft_id=info%3Adoi%2F10.1046%2Fj.1365-2036.2000.00788.x&rft_id=info%3Apmid%2F10930890&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-37"><span class="mw-cite-backlink"><a href="#cite_ref-37">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite class="citation magazine cs1">„Interaction of omeprazole, lansoprazole and pantoprazole with P-glycoprotein“. <i>Naunyn Schmiedebergs Arch Pharmacol</i>. 364-jild, № 6. December 2001. 551–557-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00210-001-0489-7">10.1007/s00210-001-0489-7</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/11770010">11770010</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Naunyn+Schmiedebergs+Arch+Pharmacol&rft.atitle=Interaction+of+omeprazole%2C+lansoprazole+and+pantoprazole+with+P-glycoprotein&rft.volume=364&rft.issue=6&rft.pages=551-557&rft.date=2001-12&rft_id=info%3Adoi%2F10.1007%2Fs00210-001-0489-7&rft_id=info%3Apmid%2F11770010&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-38"><span class="mw-cite-backlink"><a href="#cite_ref-38">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFIzzoErnst2009" class="citation magazine cs1">Izzo, AA; Ernst, E (2009). „Interactions between herbal medicines and prescribed drugs: an updated systematic review“. <i>Drugs</i>. 69-jild, № 13. 1777–1798-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F11317010-000000000-00000">10.2165/11317010-000000000-00000</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/19719333">19719333</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Interactions+between+herbal+medicines+and+prescribed+drugs%3A+an+updated+systematic+review&rft.volume=69&rft.issue=13&rft.pages=1777-1798&rft.date=2009&rft_id=info%3Adoi%2F10.2165%2F11317010-000000000-00000&rft_id=info%3Apmid%2F19719333&rft.aulast=Izzo&rft.aufirst=AA&rft.au=Ernst%2C+E&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-MD-39"><span class="mw-cite-backlink"><a href="#cite_ref-MD_39-0">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation">{{{editor}}}: <span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://www.medicinescomplete.com/mc/martindale/current/ms-9550-n.htm">„Methotrexate“</a></span>. <i>Martindale: The Complete Drug Reference</i>.  Pharmaceutical Press (2014-yil 6-yanvar). 2021-yil 28-avgustda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210828170949/https://about.medicinescomplete.com/wp-content/plugins/revslider/public/assets/js/jquery.themepunch.revolution.min.js?ver=5.4.5.2">arxivlangan</a>. Qaraldi: 2014-yil 12-aprel.</span></span></span> </li> <li id="cite_note-:0-40"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-:0_40-0">40,0</a></sup> <sup><a href="#cite_ref-:0_40-1">40,1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFHowden1991" class="citation magazine cs1">Howden, CW (January 1991). „Clinical pharmacology of omeprazole“. <i>Clinical Pharmacokinetics</i>. 20-jild, № 1. 38–49-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F00003088-199120010-00003">10.2165/00003088-199120010-00003</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/2029801">2029801</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Clinical+Pharmacokinetics&rft.atitle=Clinical+pharmacology+of+omeprazole.&rft.volume=20&rft.issue=1&rft.pages=38-49&rft.date=1991-01&rft_id=info%3Adoi%2F10.2165%2F00003088-199120010-00003&rft_id=info%3Apmid%2F2029801&rft.aulast=Howden&rft.aufirst=CW&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-:1-41"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-:1_41-0">41,0</a></sup> <sup><a href="#cite_ref-:1_41-1">41,1</a></sup> <sup><a href="#cite_ref-:1_41-2">41,2</a></sup> <sup><a href="#cite_ref-:1_41-3">41,3</a></sup></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00338">„Omeprazole“</a></span>. <i>www.drugbank.ca</i>. 2019-yil 30-yanvarda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190130053122/https://www.drugbank.ca/drugs/DB00338">arxivlangan</a>. Qaraldi: 2019-yil 29-yanvar.</span></span></span> </li> <li id="cite_note-Omeprazole-42"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Omeprazole_42-0">42,0</a></sup> <sup><a href="#cite_ref-Omeprazole_42-1">42,1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFClissoldCampoli-Richards1986" class="citation magazine cs1">Clissold, Stephen P.; Campoli-Richards, Deborah M. (July 1986). „Omeprazole“. <i>Drugs</i>. 32-jild, № 1. 15–47-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F00003495-198632010-00002">10.2165/00003495-198632010-00002</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/3527658">3527658</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Omeprazole&rft.volume=32&rft.issue=1&rft.pages=15-47&rft.date=1986-07&rft_id=info%3Adoi%2F10.2165%2F00003495-198632010-00002&rft_id=info%3Apmid%2F3527658&rft.aulast=Clissold&rft.aufirst=Stephen+P.&rft.au=Campoli-Richards%2C+Deborah+M.&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-43"><span class="mw-cite-backlink"><a href="#cite_ref-43">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFCederbergAnderssonSkånberg1989" class="citation magazine cs1">Cederberg, C.; Andersson, T.; Skånberg, I. (1 January 1989). „Omeprazole: Pharmacokinetics and Metabolism in Man“. <i>Scandinavian Journal of Gastroenterology</i>. 24-jild, № sup166. 33–40-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F00365528909091241">10.3109/00365528909091241</a>. <a href="/wiki/ISSN" class="mw-redirect" title="ISSN">ISSN</a> <a rel="nofollow" class="external text" href="//www.worldcat.org/issn/0036-5521">0036-5521</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/2690330">2690330</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Gastroenterology&rft.atitle=Omeprazole%3A+Pharmacokinetics+and+Metabolism+in+Man&rft.volume=24&rft.issue=sup166&rft.pages=33-40&rft.date=1989-01-01&rft.issn=0036-5521&rft_id=info%3Apmid%2F2690330&rft_id=info%3Adoi%2F10.3109%2F00365528909091241&rft.aulast=Cederberg&rft.aufirst=C.&rft.au=Andersson%2C+T.&rft.au=Sk%C3%A5nberg%2C+I.&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-44"><span class="mw-cite-backlink"><a href="#cite_ref-44">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFKatzGersonVela2013" class="citation magazine cs1">Katz, PO; Gerson, LB; Vela, MF (2013). „Guidelines for the diagnosis and management of gastroesophageal reflux disease“. <i>Am J Gastroenterol</i>. 108-jild, № 3. 308–28-bet. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fajg.2012.444">10.1038/ajg.2012.444</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/23419381">23419381</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Am+J+Gastroenterol&rft.atitle=Guidelines+for+the+diagnosis+and+management+of+gastroesophageal+reflux+disease&rft.volume=108&rft.issue=3&rft.pages=308-28&rft.date=2013&rft_id=info%3Adoi%2F10.1038%2Fajg.2012.444&rft_id=info%3Apmid%2F23419381&rft.aulast=Katz&rft.aufirst=PO&rft.au=Gerson%2C+LB&rft.au=Vela%2C+MF&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-45"><span class="mw-cite-backlink"><a href="#cite_ref-45">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://medical-dictionary.thefreedictionary.com/omeprazole">„Omeprazole, in The Free Medical Dictionary“</a></span>. 2011-yil 12-iyunda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110612172513/http://medical-dictionary.thefreedictionary.com/omeprazole">arxivlangan</a>. Qaraldi: 2010-yil 11-noyabr.</span></span></span> </li> <li id="cite_note-46"><span class="mw-cite-backlink"><a href="#cite_ref-46">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/omeprazole.html">„Omeprazole“</a></span>.  Drugs.com. 2011-yil 19-fevralda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20110219135631/http://www.drugs.com/monograph/omeprazole.html">arxivlangan</a>. Qaraldi: 2010-yil 11-noyabr.</span></span></span> </li> <li id="cite_note-47"><span class="mw-cite-backlink"><a href="#cite_ref-47">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="http://www.rxlist.com/zegerid-drug-patient.htm#howtake">„Zegird, How to take“</a></span>.  rxlist.com. 2010-yil 26-oktyabrda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20101026072806/http://www.rxlist.com/zegerid-drug-patient.htm#howtake">arxivlangan</a>. Qaraldi: 2010-yil 11-noyabr.</span></span></span> </li> <li id="cite_note-48"><span class="mw-cite-backlink"><a href="#cite_ref-48">↑</a></span> <span class="reference-text">Baselt RC, <i>Disposition of Toxic Drugs and Chemicals in Man</i>, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 1146-7. <a href="/wiki/Maxsus:BookSources/978-0-9626523-7-0" title="Maxsus:BookSources/978-0-9626523-7-0">ISBN <span style="white-space: nowrap;">978-0-9626523-7-0</span></a>.</span> </li> <li id="cite_note-49"><span class="mw-cite-backlink"><a href="#cite_ref-49">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://apps.who.int/medicinedocs/en/d/Js4915e/2.5.html">„Trends in Drug Patenting - Case Studies: THE CASES: 5. OMEPRAZOLE“</a></span>. <i>apps.who.int</i>. 2010-yil 2-oktyabrda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20101002080328/http://apps.who.int/medicinedocs/en/d/Js4915e/2.5.html">arxivlangan</a>. Qaraldi: 2019-yil 22-avgust.</span></span></span> </li> <li id="cite_note-Fellenius_1981-50"><span class="mw-cite-backlink"><a href="#cite_ref-Fellenius_1981_50-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFFelleniusBerglindhSachsOlbe1981" class="citation magazine cs1">Fellenius, Erik; Berglindh, Thomas; Sachs, George; Olbe, Lars; Elander, Berit; Sjöstrand, Sven-Erik; Wallmark, Björn (1981). „Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+) ATPase“. <i>Nature</i>. 290-jild, № 5802. 159–61-bet. <a href="/w/index.php?title=Bibcode&action=edit&redlink=1" class="new" title="Bibcode (sahifa yaratilmagan)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1981Natur.290..159F">1981Natur.290..159F</a>. <a href="/wiki/Doi" class="mw-redirect" title="Doi">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F290159a0">10.1038/290159a0</a>. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/6259537">6259537</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Substituted+benzimidazoles+inhibit+gastric+acid+secretion+by+blocking+%28H%2B+%2B+K%2B%29+ATPase&rft.volume=290&rft.issue=5802&rft.pages=159-61&rft.date=1981&rft_id=info%3Apmid%2F6259537&rft_id=info%3Adoi%2F10.1038%2F290159a0&rft_id=info%3Abibcode%2F1981Natur.290..159F&rft.aulast=Fellenius&rft.aufirst=Erik&rft.au=Berglindh%2C+Thomas&rft.au=Sachs%2C+George&rft.au=Olbe%2C+Lars&rft.au=Elander%2C+Berit&rft.au=Sj%C3%B6strand%2C+Sven-Erik&rft.au=Wallmark%2C+Bj%C3%B6rn&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-farley-51"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-farley_51-0">51,0</a></sup> <sup><a href="#cite_ref-farley_51-1">51,1</a></sup></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5263675" /><cite id="CITEREFFarley1995" class="citation magazine cs1">Farley, D (July–August 1995). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20120315172345/http://www.thebody.com/content/art13913.html">„Making it easier to read prescriptions“</a>. <i><a href="/w/index.php?title=FDA_Consum&action=edit&redlink=1" class="new" title="FDA Consum (sahifa yaratilmagan)">FDA Consum</a></i>. 29-jild, № 6. 25–7-bet. <a href="/w/index.php?title=PMID&action=edit&redlink=1" class="new" title="PMID (sahifa yaratilmagan)">PMID</a> <a rel="nofollow" class="external text" href="//pubmed.ncbi.nlm.nih.gov/10143448">10143448</a>. 15 March 2012da <a rel="nofollow" class="external text" href="http://www.thebody.com/content/art13913.html">asl nusxadan</a> arxivlandi<span class="reference-accessdate">. Qaraldi: <span class="nowrap">26 January</span> 2011</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=FDA+Consum&rft.atitle=Making+it+easier+to+read+prescriptions&rft.volume=29&rft.issue=6&rft.pages=25-7&rft.date=1995-07%2F1995-08&rft_id=info%3Apmid%2F10143448&rft.aulast=Farley&rft.aufirst=D&rft_id=http%3A%2F%2Fwww.thebody.com%2Fcontent%2Fart13913.html&rfr_id=info%3Asid%2Fuz.wikipedia.org%3AOmeprazol" class="Z3988"></span></span> </li> <li id="cite_note-52"><span class="mw-cite-backlink"><a href="#cite_ref-52">↑</a></span> <span class="reference-text"><span class="citation">Gardiner Harris. <a rel="nofollow" class="external text" href="https://www.wsj.com/articles/SB1023326369679910840">„Prilosec's Maker Switches Users To Nexium, Thwarting Generics“</a>. <i>The Wall Street Journal</i> (2002-yil 6-iyun). 2017-yil 6-avgustda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170806181248/https://www.wsj.com/articles/SB1023326369679910840">arxivlangan</a>.</span></span> </li> <li id="cite_note-Drugs.com_international-53"><span class="mw-cite-backlink"><a href="#cite_ref-Drugs.com_international_53-0">↑</a></span> <span class="reference-text"><span class="citation"><span class="citation"><span lang="aniqlanmagan"><a rel="nofollow" class="external text" href="https://www.drugs.com/international/omeprazole.html">„Omeprazole international“</a></span>. <i>Drugs.com</i> (2020-yil 3-fevral). 2020-yil 28-fevralda asl nusxadan <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200228060551/https://www.drugs.com/international/omeprazole.html">arxivlangan</a>. Qaraldi: 2020-yil 27-fevral.</span></span></span> </li> </ol></div></div>    </div><noscript><img src="https://auth.wikimedia.org/loginwiki/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet=""><pre>"<a dir="ltr" href="https://uz.wikipedia.org/w/index.php?title=Omeprazol&oldid=5374076">https://uz.wikipedia.org/w/index.php?title=Omeprazol&oldid=5374076</a>" dan olindi </pre></div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Maxsus:Categories" title="Maxsus:Categories">Turkum</a>: <ul><li><a href="/wiki/Turkum:Dorilar" title="Turkum:Dorilar">Dorilar</a></li><li><a href="/wiki/Turkum:Tibbiyot" title="Turkum:Tibbiyot">Tibbiyot</a></li><li><a href="/wiki/Turkum:Tibbiy_muolajalar" title="Turkum:Tibbiy muolajalar">Tibbiy muolajalar</a></li><li><a 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