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KEGG MODULE: M00563
<!doctype html> <html><head> <title>KEGG MODULE: M00563</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1742432056"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1742432056"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1742432056" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; } 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name="form1"></form><table class="w1" width="650"> <tr> <td class="fr3 w1"> <table width="650" class="w2"> <tr><th class="th30 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td30 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">M00563 Pathway Module <br> </span></code></td></tr></table></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td31 defd"><div class="cel"><div class="cel">Methanogenesis, methylamine/dimethylamine/trimethylamine => methane<br> </div></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Definition</span></th> <td class="td30 defd"><div class="cel"><div class="cel">K14082 ((K16177-K16176),(K16179-K16178),(K14084-K14083)) K00399+<wbr>K00401+<wbr>K00402 (K22480+<wbr>K22481+<wbr>K22482,K03388+<wbr>K03389+<wbr>K03390,K08264+<wbr>K08265,K03388+<wbr>K03389+<wbr>K03390+<wbr>K14127+<wbr>(K14126+<wbr>K14128,K22516+<wbr>K00125))<br> </div></div></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Diagram</span></th> <td class="td31 defd"><div class="mdthumb"><a href="/module/M00563"><img class="center" src="/kegg/misc/thumbnail/M00563.gif" alt="M00563"></a></div><br></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Orthology</span></th> <td class="td30 defd"><div class="cel"><div class="fll"><a href="/entry/K14082">K14082</a> </div><div style="margin-left:16.8px">mtbA; [methyl-Co(III) methylamine-specific corrinoid protein]:coenzyme M methyltransferase [EC:<a href="/entry/2.1.1.247">2.1.1.247</a>] [RN:<a href="/entry/R09998">R09998</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K16176">K16176</a> </div><div style="margin-left:16.8px">mtmB; methylamine---corrinoid protein Co-methyltransferase [EC:<a href="/entry/2.1.1.248">2.1.1.248</a>] [RN:<a href="/entry/R09998">R09998</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K16177">K16177</a> </div><div style="margin-left:16.8px">mtmC; monomethylamine corrinoid protein [RN:<a href="/entry/R09998">R09998</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K16178">K16178</a> </div><div style="margin-left:16.8px">mtbB; dimethylamine---corrinoid protein Co-methyltransferase [EC:<a href="/entry/2.1.1.249">2.1.1.249</a>] [RN:<a href="/entry/R09999">R09999</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K16179">K16179</a> </div><div style="margin-left:16.8px">mtbC; dimethylamine corrinoid protein [RN:<a href="/entry/R09999">R09999</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K14083">K14083</a> </div><div style="margin-left:16.8px">mttB; trimethylamine---corrinoid protein Co-methyltransferase [EC:<a href="/entry/2.1.1.250">2.1.1.250</a>] [RN:<a href="/entry/R09124">R09124</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K14084">K14084</a> </div><div style="margin-left:16.8px">mttC; trimethylamine corrinoid protein [RN:<a href="/entry/R09124">R09124</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K00399">K00399</a>+<a href="/entry/K00401">K00401</a>+<a href="/entry/K00402">K00402</a> </div><div style="margin-left:16.8px">methyl-coenzyme M reductase [EC:<a href="/entry/2.8.4.1">2.8.4.1</a>] [RN:<a href="/entry/R04541">R04541</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K22480">K22480</a>+<a href="/entry/K22481">K22481</a>+<a href="/entry/K22482">K22482</a> </div><div style="margin-left:16.8px">heterodisulfide reductase 1 [EC:<a href="/entry/1.8.7.3">1.8.7.3</a>] [RN:<a href="/entry/R11931">R11931</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K03388">K03388</a>+<a href="/entry/K03389">K03389</a>+<a href="/entry/K03390">K03390</a> </div><div style="margin-left:16.8px">heterodisulfide reductase 2 [EC:<a href="/entry/1.8.7.3">1.8.7.3</a> <a href="/entry/1.8.98.4">1.8.98.4</a> <a href="/entry/1.8.98.5">1.8.98.5</a> <a href="/entry/1.8.98.6">1.8.98.6</a>] [RN:<a href="/entry/R11928">R11928</a> <a href="/entry/R11931">R11931</a> <a href="/entry/R11943">R11943</a> <a href="/entry/R11944">R11944</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K08264">K08264</a>+<a href="/entry/K08265">K08265</a> </div><div style="margin-left:16.8px">heterodisulfide reductase [EC:<a href="/entry/1.8.98.1">1.8.98.1</a>] [RN:<a href="/entry/R04540">R04540</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K14126">K14126</a>+<a href="/entry/K14128">K14128</a> </div><div style="margin-left:16.8px">F420-non-reducing hydrogenase [EC:<a href="/entry/1.8.98.5">1.8.98.5</a>] [RN:<a href="/entry/R11943">R11943</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K14127">K14127</a> </div><div style="margin-left:16.8px">F420-non-reducing hydrogenase iron-sulfur subunit [EC:<a href="/entry/1.8.98.5">1.8.98.5</a> <a href="/entry/1.8.98.6">1.8.98.6</a>] [RN:<a href="/entry/R11943">R11943</a> <a href="/entry/R11944">R11944</a>]</div><div class="fcb"></div><div class="fll"><a href="/entry/K22516">K22516</a>+<a href="/entry/K00125">K00125</a> </div><div style="margin-left:16.8px">formate dehydrogenase (coenzyme F420) [EC:<a href="/entry/1.8.98.6">1.8.98.6</a>] [RN:<a href="/entry/R11944">R11944</a>]</div><div class="fcb"></div></div><button class="btn" onclick="location.href='https://www.kegg.jp/kegg-bin/view_ortholog_table?md=M00563';return false;">Ortholog table</button><button class="btn" onclick="location.href='/kegg-bin/show_taxonomy?id=M00563';return false;">Taxonomy</button></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td31 defd"><div class="cel">Pathway modules; Energy metabolism; Methane metabolism<br> <button class="btn" onclick="location.href='/kegg-bin/search_htext?htext=ko00002.keg&option=-a&query=M00563';return false;">BRITE hierarchy</button></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Pathway</span></th> <td class="td30 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map00680+M00563">map00680</a> </span></td><td>Methane metabolism</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map01200+M00563">map01200</a> </span></td><td>Carbon metabolism</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map01100+M00563">map01100</a> </span></td><td>Metabolic pathways</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map01120+M00563">map01120</a> </span></td><td>Microbial metabolism in diverse environments</td></tr></table></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Reaction</span></th> <td class="td31 defd"><div class="cel"><div class="fll"><a href="/entry/R09998">R09998</a> </div><div style="margin-left:16.8px"><a href="/entry/C00218">C00218</a> -> <a href="/entry/C03920">C03920</a></div><div class="fcb"></div><div class="fll"><a href="/entry/R09999">R09999</a> </div><div style="margin-left:16.8px"><a href="/entry/C00543">C00543</a> -> <a href="/entry/C03920">C03920</a></div><div class="fcb"></div><div class="fll"><a href="/entry/R09124">R09124</a> </div><div style="margin-left:16.8px"><a href="/entry/C00565">C00565</a> -> <a href="/entry/C03920">C03920</a> </div><div class="fcb"></div><div class="fll"><a href="/entry/R04541">R04541</a> </div><div style="margin-left:16.8px"><a href="/entry/C03920">C03920</a> + <a href="/entry/C04628">C04628</a> -> <a href="/entry/C01438">C01438</a> + <a href="/entry/C04832">C04832</a></div><div class="fcb"></div><div class="fll"><a href="/entry/R11931">R11931</a>,<a href="/entry/R04540">R04540</a>,<a href="/entry/R11928">R11928</a>,<a href="/entry/R11943">R11943</a>,<a href="/entry/R11944">R11944</a> </div><div style="margin-left:16.8px"><a href="/entry/C04832">C04832</a> -> <a href="/entry/C04628">C04628</a></div><div class="fcb"></div></div></td></tr> <tr><th class="th30 deft tal vtop"><span class="nowrap">Compound</span></th> <td class="td30 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C00218">C00218</a> </span></td><td>Methylamine</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C03920">C03920</a> </span></td><td>2-(Methylthio)ethanesulfonate</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C00543">C00543</a> </span></td><td>Dimethylamine</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C00565">C00565</a> </span></td><td>Trimethylamine</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C04628">C04628</a> </span></td><td>Coenzyme B</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C01438">C01438</a> </span></td><td>Methane</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/entry/C04832">C04832</a> </span></td><td>Coenzyme M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide</td></tr></table></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td31 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/9642198">9642198</a></div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td30 repd"><div class="cel">Burke SA, Lo SL, Krzycki JA</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td31 repd"><div class="cel">Clustered genes encoding the methyltransferases of methanogenesis from monomethylamine.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td30 repd"><div class="cel">J Bacteriol 180:3432-40 (1998)<br>DOI:<a href="https://doi.org/10.1128/JB.180.13.3432-3440.1998">10.1128/JB.180.13.3432-3440.1998</a></div></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td31 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/20847933">20847933</a></div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td30 repd"><div class="cel">Rother M, Krzycki JA</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td31 repd"><div class="cel">Selenocysteine, pyrrolysine, and the unique energy metabolism of methanogenic archaea.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td30 repd"><div class="cel">Archaea 2010:453642 (2010)<br>DOI:<a href="https://doi.org/10.1155/2010/453642">10.1155/2010/453642</a></div></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td31 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/15882413">15882413</a></div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td30 repd"><div class="cel">Pritchett MA, Metcalf WW</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td31 repd"><div class="cel">Genetic, physiological and biochemical characterization of multiple methanol methyltransferase isozymes in Methanosarcina acetivorans C2A.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td30 repd"><div class="cel">Mol Microbiol 56:1183-94 (2005)<br>DOI:<a href="https://doi.org/10.1111/j.1365-2958.2005.04616.x">10.1111/j.1365-2958.2005.04616.x</a></div></td></tr> <tr><th class="th31 deft tal vtop"><span class="nowrap">Reference</span></th> <td class="td31 defd"><div class="cel">PMID:<a href="https://www.ncbi.nlm.nih.gov/pubmed/16096277">16096277</a></div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Authors</span></th> <td class="td30 repd"><div class="cel">Soares JA, Zhang L, Pitsch RL, Kleinholz NM, Jones RB, Wolff JJ, Amster J, Green-Church KB, Krzycki JA</div></td></tr> <tr><th class="th31 rept tal vtop"><span class="nowrap"> Title</span></th> <td class="td31 repd"><div class="cel">The residue mass of L-pyrrolysine in three distinct methylamine methyltransferases.</div></td></tr> <tr><th class="th30 rept tal vtop"><span class="nowrap"> Journal</span></th> <td class="td30 repd"><div class="cel">J Biol Chem 280:36962-9 (2005)<br>DOI:<a href="https://doi.org/10.1074/jbc.M506402200">10.1074/jbc.M506402200</a></div></td></tr> <tr><th class="th31 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td31 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?module+M00563';return false;">All DBs</button></td></tr> </table></td></tr></table> <br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>