CINXE.COM

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et_pharm_browser_wrapper"> <h1>Nerve Growth Factor IB-like Receptors</h1> <p><strong>Nerve growth factor IB-like receptors (nuclear hormone receptor 4A, NR4A)</strong> are a group of orphan nuclear receptors, comprising three members Nur77 (NR4A1), Nurr1 (NR4A2) and NOR1 (NR4A3). They are widely expressed and have a role in immune and energy regulation, as well as being implicated in a range of cancers.</p> <div class="tabbed_content"> <div class="tab_menu"> <div class="tab tab_1 tab_open" data-tab="1" data-tabname="products" id="pharm_tabs_products"> <span>Products</span></div> <div class="tab tab_2" data-tab="2" data-tabname="background" id="pharm_tabs_background"><span>Background</span> </div> <div class="tab tab_4" data-tab="4" data-tabname="literature" id="pharm_tabs_literature"><span>Literature (1)</span> </div> <div class="tab tab_5" data-tab="5" data-tabname="pathways" id="pharm_tabs_pathways"><span>Pathways (2)</span> </div> <div class="tab tab_6" data-tab="6" data-tabname="gene" id="pharm_tabs_gene"> <span>Gene Data</span></div> </div> <div class="tab_content tab_1 tab_open" data-tab="1"> <div class="pharm_products"><table class="pharm_prod_table table table-condensed"> <tr> <th colspan="2"><h3><a href="/pharmacology/nerve-growth-factor-ib-like-receptors/agonists" title="View all Nerve Growth Factor IB-like Receptor Agonist products">Nerve Growth Factor IB-like Receptor Agonists</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>5459</td> <td><a href="/products/cytosporone-b_5459" title="View price & availability information for Cytosporone B">Cytosporone B</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>High affinity Nur77 agonist</td> </tr> <tr> <th colspan="2"><h3><a href="/pharmacology/nerve-growth-factor-ib-like-receptors/antagonists" title="View all Nerve Growth Factor IB-like Receptor Antagonist products">Nerve Growth Factor IB-like Receptor Antagonists</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>6377</td> <td><a href="/products/dim-c-pphoh_6377" title="View price & availability information for DIM-C-pPhOH">DIM-C-pPhOH</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Nur77 antagonist</td> </tr> <tr> <th colspan="2"><h3><a href="/pharmacology/nerve-growth-factor-ib-like-receptors/activators" title="View all Nerve Growth Factor IB-like Receptor Activator products">Nerve Growth Factor IB-like Receptor Activators</a></h3></th> </tr> <tr> <th>Cat. No.</th> <th>Product Name / Activity</th> </tr> <tr> <td>5821</td> <td><a href="/products/c-dim-12_5821" title="View price & availability information for C-DIM 12">C-DIM 12</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Nurr1 activator; inhibits NF-魏B-dependent gene expression</td> </tr> <tr> <td>5699</td> <td><a href="/products/ip7e_5699" title="View price & availability information for IP7e">IP7e</a></td> </tr> <tr class="pharm_prod_table_action"> <td></td><td>Potent Nurr1 activator</td> </tr></table></div> </div> <div class="tab_content tab_2" data-tab="2"> <p>NR4As are constitutively active and no endogenous ligands have been identified to date. The effects of these receptors are context and tissue dependent, and are governed by their expression levels, post-translational modification and interaction with other transcription factors.</p> <p>NR4As are key regulators of <a href='/research-area/pain-and-inflammation-research' title = 'Browse products for Inflammation Research'>inflammatory</a> processes and <a href='/research-area/immunology-research' title = 'Browse products for Immunology Research'>immune</a> homeostasis and are expressed at high levels in chronically inflamed tissues, such as in atherosclerosis, psoriasis, colitis or rheumatoid arthritis. They integrate and limit inflammatory signaling and promote tissue repair, so are potentially a target of interest for anti-inflammatory therapies. NR4A gene expression is regulated by <a href='/cell-biology/nf-kappab-and-i-kappab' title = 'Browse products for NF-κB'>NF-κB</a>, but NR4As also have a regulatory feedback role controlling NF-κB activity and pro-inflammatory target gene expression by suppressing NF-κB transcriptional activity.</p> <p><a href='/research-area/cancer-research' title = 'Browse products for Cancer Research'>Cancer</a> is another area in which NR4As are implicated. They have pro-angiogenic effects via the <a href='/pharmacology/vegfr' title = 'Browse products for VEGF Receptors'>VEGF</a> pathway, as well as affecting <a href='/cell-biology/p53' title = 'Browse products for p53'>p53</a>, <a href='/pharmacology/mapk-family' title = 'Browse products for MAPK'>MAPK</a> and <a href='/cell-biology/wnt-signaling' title = 'Browse products for Wnt signaling'>Wnt/β catenin</a> pathways leading to <a href='/cell-biology/apoptosis' title = 'Browse products for Apoptosis Research'>anti-apoptotic</a> and proliferative effects. NR4As are also involved in the DNA damage response, translocating to sites of dsDNA damage repair in a mechanism that is dependent on <a href='/pharmacology/polyadp-ribose-polymerase' title = 'Browse products for Poly(ADP-ribose) Polymerase'>PARP-1</a>. In addition NR4A2 receptors have been reported to be involved in inducing expression of enzymes associated with fatty acid oxidation in colon cancer cells, allowing cells to switch to alternative oxidative pathways so promoting cell survival.</p> <p>NR4As are also important in lipid, carbohydrate and energy metabolism and may be of interest in dyslipidemia, <a href='/research-area/obesity-research' title = 'Browse products for Obesity Research'>obesity</a>, <a href='/research-area/diabetes-research' title = Browse products for Diabetes Research'>diabetes</a> and <a href='/research-area/cardiovascular-system-research' title = 'Browse products for Cardiovascular Research'>cardiovascular</a> disease. In muscle, adipose tissue and liver, NR4As are induced by β-adrenergic signaling, and are thought to transcriptionally regulate metabolic function. This effect is mediated by<a href='/cell-biology/camp' title= 'Browse products for cAMP'> cAMP</a>, <a href='/pharmacology/protein-kinase-a' title = 'Browse products for Protein Kinase A'>protein kinase A</a>, MAPK and cAMP response element-binding protein. In the liver, NR4As are also induced by glucagon and fasting, resulting in gluconeogenesis. Increased expression in liver also leads to reduced hepatic triglyceride content and reduced expression of <a href='/cell-biology/srebp' title = Browse products for SREBP'>SREBP-1c</a>, a regulator of lipid and cholesterol metabolism. In brown adipose tissue NR4As may also be induced by cold and during adipogenesis, while in white adipose tissue, insulin and insulin sensitizers increase expression of these receptors. In addition, NR4As are induced by atherogenic stimuli, are expressed in <a href='/research-area/atherosclerosis-research' title = 'Browse products for Atherosclerosis Research'>atherosclerotic plaques</a> and activated in smooth muscle cells by vascular disease.</p><h3>External sources of pharmacological information for Nerve Growth Factor IB-like Receptors : </h3><ul class="tile_column_1"><li><a href="https://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=99" target="_blank" rel="nofollow">IUPHAR Receptor Code</a></li></ul><ul class="tile_column_2"><li><a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.13884" target="_blank" rel="nofollow">BJP Guide</a></li></ul> </div> <div class="tab_content tab_3" data-tab="3"> </div> <div class="tab_content tab_4" data-tab="4"> <h3>Literature for Nerve Growth Factor IB-like Receptors</h3><p>Tocris offers the following scientific literature for Nerve Growth Factor IB-like Receptors to showcase our products. We invite you to request* your copy today!</p><p class="small">*Please note that Tocris will only send literature to established scientific business / institute addresses.</p><hr/><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="https://resources.tocris.com/images/literature/reviews/fullsize/522385.jpg?v=1" data-toggle="lightbox" data-title="MAPK Signaling Scientific Review" data-footer="<a href='/literature/literature-request/522385' rel='nofollow' title='Request copy of the MAPK Signaling'>Request copy</a> or <a href='/literature/literature-request/p522385' rel='nofollow' title='Request PDF of the MAPK Signaling'>Request PDF</a> today"><img loading="lazy" src="https://resources.tocris.com/images/literature/reviews/regular/522385.jpg?v=1" alt="MAPK Signaling Scientific Review" class="img-fluid"></a></div> <h4>MAPK Signaling Scientific Review</h4> <p>MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.</p> <ul class="pb_lit_buttons"><li> <a class="btn btn-quinary" href="/literature/literature-request/522385" rel="nofollow" title="Request copy of the MAPK Signaling Scientific Review">Request copy</a> </li><li> <a class="btn btn-quinary request-pdf" href="/literature/literature-request/p522385" rel="nofollow" title="Request PDF of the MAPK Signaling Scientific Review">Request PDF<div class="lit_request_pdf"></div></a> </li> <li><a class="btn btn-quinary" href="/literature/scientific-reviews" title="View all Scientific Reviews">View all Scientific Reviews</a></li> </ul> </div></div> </div> <div class="tab_content tab_5" data-tab="5"> <h3>Pathways for Nerve Growth Factor IB-like Receptors</h3><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="/pathways/mapk-signaling-pathway"><img loading="lazy" src="https://resources.tocris.com/images/literature/pathways/regular/297495.jpg" alt="MAPK Signaling Pathway "></a></div> <h4><a href="/pathways/mapk-signaling-pathway">MAPK Signaling Pathway</a></h4> The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival. <ul class="pb_lit_buttons"> <li><a class="btn btn-quinary" href="/pathways/mapk-signaling-pathway" title="View MAPK Signaling Pathway">View Pathway</a></li> <li><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pathways/pdf/mapk.pdf" download="https://resources.tocris.com/pathways/pdf/mapk.pdf" rel="nofollow" target="_blank" title="Download PDF of the MAPK Signaling Pathway" data-title="MAPK Signaling Pathway">Download PDF</a></li> <li><a class="btn btn-quinary" href="/signaling-pathways" title="View all Pathways">View all Pathways</a></li> </ul> </div></div><div class="lit_item"> <div class="lit_content"> <div class="lit_image"> <a href="/pathways/nf-kappab-signaling-pathway"><img loading="lazy" src="https://resources.tocris.com/images/literature/pathways/regular/299045.jpg" alt="NF-κB Signaling Pathway "></a></div> <h4><a href="/pathways/nf-kappab-signaling-pathway">NF-κB Signaling Pathway</a></h4> NF-<span class='symbol'>κ</span>B signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases. <ul class="pb_lit_buttons"> <li><a class="btn btn-quinary" href="/pathways/nf-kappab-signaling-pathway" title="View NF-κB Signaling Pathway">View Pathway</a></li> <li><a class="btn btn-quinary pdf-download" href="https://resources.tocris.com/pathways/pdf/nfkb.pdf" download="https://resources.tocris.com/pathways/pdf/nfkb.pdf" rel="nofollow" target="_blank" title="Download PDF of the NF-κB Signaling Pathway" data-title="NF-κB Signaling Pathway">Download PDF</a></li> <li><a class="btn btn-quinary" href="/signaling-pathways" title="View all Pathways">View all Pathways</a></li> </ul> </div></div> </div> <div class="tab_content tab_6" data-tab="6"> <H3>Nuclear Receptor Subfamily 4 Group A Member 1 Gene Data</H3> <table class="table table-responsive"> <tr> <th style='width:21%' title='Gene'> Gene </th> <th style='width:13%' title='Species'> Species </th> <th style='width:16%' title='The official gene symbol that has been approved by the HGNC'> Gene Symbol </th> <th style='width:25%' title='A unique identifier for a gene sequence record from the Reference Sequence database'> Gene Accession No. </th> <th style='width:25%' title='A unique identifier for a protein sequence record from the UniProt Protein Knowledgebase'> Protein Accession No. </th> </tr> <tr> <td style='width:21%' class='pb_bld' rowspan='3'> NR4A1 </td> <td style='width:13%' class='pb_bld'> Human </td> <td style='width:16%'> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7980' target='_blank'>NR4A1</a> </td> <td style='width:25%'> NM_001202233 </td> <td style='width:25%'> P22736 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:1352454' target='_blank'>Nr4a1</a> </td> <td> NM_010444 </td> <td> P12813 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=RGD:620029' target='_blank'>Nr4a1</a> </td> <td> NM_024388 </td> <td> NP_077364 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> NR4A2 </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7981' target='_blank'>NR4A2</a> </td> <td> NM_006186 </td> <td> P43354 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:1352456' target='_blank'>Nr4a2</a> </td> <td> NM_013613 </td> <td> Q06219 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=RGD:3202' target='_blank'>Nr4a2</a> </td> <td> NM_019328 </td> <td> NP_062201 </td> </tr> <tr> <td class='pb_bld' rowspan='3'> NR4A3 </td> <td class='pb_bld'> Human </td> <td> <a href='https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7982' target='_blank'>NR4A3</a> </td> <td> NM_006981 </td> <td> Q92570 </td> </tr> <tr> <td class='pb_bld'> Mouse </td> <td> <a href='https://www.informatics.jax.org/marker/MGI:1352457' target='_blank'>Nr4a3</a> </td> <td> NM_015743 </td> <td> Q9QZB6 </td> </tr> <tr> <td class='pb_bld'> Rat </td> <td> <a href='https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=RGD:61882' target='_blank'>Nr4a3</a> </td> <td> NM_031628 </td> <td> NP_113816 </td> </tr> </table> </div> </div> </div> <div id="sidebar" class="col-xs-12 col-sm-4 col-md-3 col-lg-3 col-xl-3"> <div class="resources_sidebar_container"> <div class="fp_four_box"> <div class="fp_box_wrapper"><h3>Featured New Products</h3> <div class="fp_featured_product"><a href="/products/vu-0542270_8151">8151 | VU 0542270</a><br /> Selective inhibitor of K<sub>ir</sub>6.1 K<sub>ATP</sub> channels</div> <div class="fp_featured_product"><a href="/products/rna-imaging-probe-1c_8813">8813 | RNA Imaging Probe 1c</a><br /> Fluorogenic RNA imaging probe</div> <div class="fp_featured_product"><a href="/products/lsn-3318839_7959">7959 | LSN 3318839</a><br /> Glucagon-like 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