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frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Arbeitsgruppe PD Dr. rer. nat. Stefan Wirtz</span></h2><h3 class="element-subheader "><span>Angeborene Mechanismen der Organentz眉ndung</span></h3></div></div></div></div></div></div><div id="c85208" class=" frame frame-default frame-type-custom_linklist frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="d-grid link-items layout-simple "><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-s-wirtz/" class="stretched-link">Allgemein</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-s-wirtz/projekte/" class="stretched-link">Projekte</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-s-wirtz/mitarbeiter/" class="stretched-link">Mitarbeiter</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-s-wirtz/foerderung/" class="stretched-link">F枚rderung</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div><div class="card card--no-border card--hover bg-linklist-default"><div class="d-grid link-item"><div class="link-item-title card-text"><a href="https://www.medizin1.uk-erlangen.de/forschung/arbeitsgruppen/ag-pd-dr-s-wirtz/publikationen/" class="stretched-link">Publikationen</a></div><div class="link-item-icon card-text"><span class="d-block h4 link text-primary"></span></div></div></div></div></div></div></div></div></div></div><div class="section section-default"><div id="c13282" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Publikationen</span></h2></div></div></div></div></div></div><div id="c102363" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>2025</span></h3></div><p>Erkert L, Ruder B, Kabisch M, Gamez Belmonte R, Patankar JV, Gonzalez Acera M, Sch枚del L, Chiriac MT, Cineus R, Gnafakis S, Leupold T, Thoma OM, Stolzer I, Taut A, Thonn V, Zundler S, G眉nther C, Diefenbach A, K眉hl AA, Hegazy AN, Waldner M, Basic M, Bleich A, Neurath MF, <strong>Wirtz S</strong>, Becker C; TRR241 IBDome Consortium. TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice. Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00003-0. doi: 10.1016/j.mucimm.2025.01.003.</p><p>Bao LL, Yu YQ, Gonz谩lez-Acera M, Patankar JV, Giessl A, Sturm G, K眉hl AA, Atreya R, Erkert L, G谩mez-Belmonte R, Krug SM, Schmid B, Tripal P, Chiriac MT, Hildner K, Siegmund B, <strong>Wirtz S</strong>, St眉rzl M, Mohamed Abdou M, Trajanoski Z; TRR241 IBDome Consortium; Neurath MF, Zorzano A, Becker C. Epithelial OPA1 links mitochondrial fusion to inflammatory bowel disease. Sci Transl Med. 2025 Jan 15;17(781):eadn8699. doi: 10.1126/scitranslmed.adn8699. Epub 2025 Jan 15.</p><p>Meng X, Asadi-Asadabad S, Cao S, Song R, Lin Z, Safhi M, Qin Y, Tcheumi Tactoum E, Taudte V, Ekici A, Mielenz D, <strong>Wirtz S</strong>, Schett G, Bozec A. Metabolic rewiring controlled by HIF-1伪 tunes IgA-producing B-cell differentiation and intestinal inflammation. Cell Mol Immunol. 2025 Jan;22(1):54-67. doi: 10.1038/s41423-024-01233-y.</p><p>M眉ller TM, Liu LJ, Wiesinger M; TRR241 IBDome Consortium; Neurath MF, Voskens CJ, Zundler S. Engineering Therapeutic Regulatory T Cells to Overexpress G Protein-Coupled Receptor 15 Improves Functional Fitness for In Vivo Gut Homing. Gastroenterology. 2025 Feb;168(2):389-392.e4. doi: 10.1053/j.gastro.2024.10.003.</p><p>Horn V, Cancino CA, Steinheuer LM, Obermayer B, Fritz K, Nguyen AL, Juhran KS, Plattner C, B枚sel D, Oldenburg L, Burns M, Schulz AR, Saliutina M, Mantzivi E, Lissner D, Conrad T, Mashreghi MF, Zundler S, Sonnenberg E, Schumann M, Haag LM, Beule D, Flatz L; TRR241 IBDome Consortium; Trajanoski Z, D'Haens G, Weidinger C, Mei HE, Siegmund B, Thurley K, Hegazy AN. Multimodal Profiling of Peripheral Blood Identifies Proliferating Circulating Effector CD4+ T Cells as Predictors for Response to Integrin 伪4尾7-Blocking Therapy in Inflammatory Bowel Disease. Gastroenterology. 2025 Feb;168(2):327-343. doi: 10.1053/j.gastro.2024.09.021.</p><p> </p><p> </p></div></div></div></div></div><div id="c102361" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>2024</span></h3></div><p>Westermann S, Radtke D, Kramer L, <strong>Wirtz S</strong>, Voehringer D. Activation of STAT6 in Intestinal Epithelial Cells Predisposes to Gut Inflammation. Eur J Immunol. 2024 Dec 13:e202451394. doi: 10.1002/eji.202451394.</p><p>Yang Z, Krammer S, Mitl盲nder H, Grund JC, Zirlik S, <strong>Wirtz S</strong>, Rauh M, Shermeh AS, Finotto S. NFATc1 in CD4<sup>+</sup> T cells and CD11c<sup>+</sup> dendritic cells drives TH2-mediated eosinophilic inflammation in allergic asthma. J Allergy Clin Immunol Glob. 2024 Oct 18;4(1):100355. doi: 10.1016/j.jacig.2024.100355. </p><p>G谩mez-Belmonte R, Wagner Y, Mahapatro M, Wang R, Erkert L, Gonz谩lez-Acera M, Cineus R, Hainbuch S, Patankar JV, Voehringer D, Hegazy AN, Neurath MF, <strong>Wirtz S</strong>, Becker C. Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis. Sci Rep. 2024 Nov 3;14(1):26522. doi: 10.1038/s41598-024-78336-z.</p><p>Dorner H, Stolzer I, Mattner J, Kaminski S, Leistl S, Edrich LM, Schwendner R, Hobauer J, Sebald A, Leikam S, Gonzalez Acera M, D眉ll M, Lang R, Seidel G, Seitz T, Hellerbrand C, Fuhrmann G, Distler U, Tenzer S, Eichhorn P, Vieth M, Schramm C, Arnold P, Becker C, Weidinger C, Siegmund B, Atreya R, Leppkes M, Naschberger E, Sampaziotis F, Dietrich P, Rauh M, <strong>Wirtz S</strong>, Kremer AE, Neurath MF, G眉nther C. Gut Pathobiont-Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis-Associated Inflammatory Bowel Disease. Gastroenterology. 2024 Nov;167(6):1183-1197.e16. doi: 10.1053/j.gastro.2024.06.032.</p><p>Jaeger M, Dietschmann A, Austermeier S, Din莽er S, Porschitz P, Vornholz L, Maas RJA, Sprenkeler EGG, Ruland J, Wirtz S, Azam T, Joosten LAB, Hube B, Netea MG, Dinarello CA, Gresnigt MS. Alpha1-antitrypsin impacts innate host-pathogen interactions with <i>Candida albicans</i> by stimulating fungal filamentation. Virulence. 2024 Dec;15(1):2333367. doi: 10.1080/21505594.2024.2333367.</p><p>Lehmann M, Weixler B, Elezkurtaj S, Loddenkemper C; TRR241 IBDome Consortium; K眉hl AA, Siegmund B. Spatial Single Cell Profiling Using Imaging Mass Cytometry: Inflammatory Versus Penetrating Crohn's Disease. J Crohns Colitis. 2024 Aug 14;18(8):1305-1318. doi: 10.1093/ecco-jcc/jjae033.</p><p>Visconti V*, Wirtz S*, Schiffer M, M眉ller-Deile J. Distinct Changes in Gut Microbiota of Patients With Kidney Graft Rejection. Transplant Direct. 2024 Feb 16;10(3):e1582. doi: 10.1097/TXD.0000000000001582 *shared authorship</p><p>Schulz-Kuhnt A, R眉hle K, Javidmehr A, D枚br枚nti M, Biwank J, Knittel S, Neidlinger P, Leupold J, Liu LJ, Dedden M, Taudte RV, Gessner A, Fromm MF, Mielenz D, Kreiss L, Waldner MJ, Sch眉rmann S, Friedrich O, Dietel B, L贸pez-Posadas R, Plattner C; TRR241 IBDome Consortium; Zundler S, Becker C, Atreya R, Neurath MF, Atreya I. ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo. Gut. 2024 Mar 7;73(4):601-612. doi: 0.1136/gutjnl-2023-330543.</p><p>Chiriac MT, Hracsko Z, G眉nther C, Gonzalez-Acera M, Atreya R, Stolzer I, Wittner L, Dressel A, Schickedanz L, Gamez-Belmonte R, Erkert L, Hundorfean G, Zundler S, Rath T, Vetrano S, Danese S, Sturm G, Trajanoski Z, K眉hl AA, Siegmund B, Hartmann A, Wirtz S, Siebler J, Finotto S, Becker C, Neurath MF. IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling. Gut. 2024 Jan 5;73(2):282-297. doi: 10.1136/gutjnl-2023-329628.</p></div></div></div></div></div><div id="c102360" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>2023</span></h3></div><p>Ullrich KA, Derdau J, Baltes C, Battistella A, Rosso G, Uderhardt S, Schulze LL, Liu LJ, Dedden M, Spocinska M, Kainka L, Kub谩nkov谩 M, M眉ller TM, Schmidt NM, Becker E, Ben Brahim O, Atreya I, Finotto S, Prots I, <strong>Wirtz S</strong>, Weigmann B, L贸pez-Posadas R, Atreya R, Ekici AB, Lautenschl盲ger F, Guck J, Neurath MF, Zundler S. IL-3 receptor signalling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells. Gut. 2023 Nov;72(11):2081-2094. doi: 10.1136/gutjnl-2023-329818.</p><p>Zogorean R, <strong>Wirtz S</strong>. The yin and yang of B cells in a constant state of battle: intestinal inflammation and inflammatory bowel disease. Front Immunol. 2023 Oct 2;14:1260266. doi: 10.3389/fimmu.2023.1260266.</p><p>Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte RV, Wirtz S, Tanaka Y, Winkler TH, Schett G, Soulat D, Bozec A. High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic 纬未 T cell IL-17 production. Cell Rep. 2023 Jul 25;42(7):112713. doi: 10.1016/j.celrep.2023.112713.</p><p>Lenk C, Messbacher ME, Abel J, Mueller SK, Mantsopoulos K, Gostian AO, Sievert M, Wirtz S, Marxreiter F, Winkler J, Iro H, Traxdorf M. The influence of obstructive sleep apnea and continuous positive airway pressure on the nasal microbiome. Eur Rev Med Pharmacol Sci. 2023 Mar;27(6):2605-2618. doi: 10.26355/eurrev_202303_31797.</p><p>Kneis B, <strong>Wirtz S</strong>, Weber K, Denz A, Gittler M, Geppert C, Brunner M, Krautz C, Siebenh眉ner AR, Schierwagen R, Tyc O, Agaimy A, Gr眉tzmann R, Trebicka J, Kersting S, Langheinrich M. Colon Cancer Microbiome Landscaping: Differences in Right- and Left-Sided Colon Cancer and a Tumor Microbiome-Ileal Microbiome Association. Int J Mol Sci. 2023 Feb 7;24(4):3265. doi: 10.3390/ijms24043265.</p><p>Schick J, Altunay M, Lacorcia M, Marschner N, Westermann S, Schluckebier J, Schubart C, Bodendorfer B, Christensen D, Alexander C, Wirtz S, Voehringer D, daCosta CP, Lang R. IL-4 and helminth infection downregulate MINCLE-dependent macrophage response to mycobacteria and Th17 adjuvanticity. Elife. 2023 Feb 8;12:e72923. doi: 10.7554/eLife.72923.</p></div></div></div></div></div><div id="c102359" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h3 class="element-header "><span>2022</span></h3></div><p>Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, 脰lke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Kr枚nke G, Murray PJ, <strong>Wirtz S</strong>, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, L眉hrmann A, Lang R. Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever. EMBO Mol Med. 2023 Feb 8;15(2):e15931. doi: 10.15252/emmm.202215931. </p><p>Leupold T, <strong>Wirtz S</strong>. ILCs-Crucial Players in Enteric Infectious Diseases. Int J Mol Sci. 2022 Nov 17;23(22):14200. doi: 10.3390/ijms232214200</p><p>Schmalzl A, Leupold T, Kreiss L, Waldner M, Sch眉rmann S, Neurath MF, Becker C, <strong>Wirtz S</strong>. Interferon regulatory factor 1 (IRF-1) promotes intestinal group 3 innate lymphoid responses during Citrobacter rodentium infection. Nat Commun. 2022 Sep 29;13(1):5730. doi: 10.1038/s41467-022-33326-5.</p><p>Zhang J, <strong>Wirtz S</strong>. Does Pyroptosis Play a Role in Inflammasome-Related Disorders? Int J Mol Sci. 2022 Sep 9;23(18):10453. doi: 10.3390/ijms231810453.</p><p>Varela F, Symowski C, Pollock J, <strong>Wirtz S</strong>, Voehringer D. IL-4/IL-13-producing ILC2s are required for timely control of intestinal helminth infection in mice. Eur J Immunol. 2022 Dec;52(12):1925-1933. doi: 10.1002/eji.202249892.</p><p>Gerlach K, Popp V, <strong>Wirtz S</strong>, Al-Saifi R, Gonzalez Acera M, Atreya R, Dregelies T, Vieth M, Fichtner-Feigl S, McKenzie ANJ, Rosenbauer F, Weigmann B, Neurath MF. PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells. J Crohns Colitis. 2022 Dec 5;16(12):1893-1910. doi: 10.1093/ecco-jcc/jjac097.</p><p>Tisch N, Mogler C, Stojanovic A, Luck R, Korhonen EA, Ellerkmann A, Adler H, Singhal M, Schermann G, Erkert L, Patankar JV, Karakatsani A, Scherr AL, Fuchs Y, Cerwenka A, <strong>Wirtz S</strong>, K枚hler BC, Augustin HG, Becker C, Schmidt T, Ruiz de Almod贸var C. Caspase-8 in endothelial cells maintains gut homeostasis and prevents small bowel inflammation in mice. EMBO Mol Med. 2022 Jun 8;14(6):e14121. doi: 10.15252/emmm.202114121.</p><p>Frech M, Omata Y, Schmalzl A, <strong>Wirtz S</strong>, Taher L, Schett G, Zaiss MM, Sarter K. Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses. Front Immunol. 2022 Jan 25;13:757436. doi: 10.3389/fimmu.2022.757436.</p><p>Stolzer I, Schickedanz L, Chiriac MT, L贸pez-Posadas R, Grassl GA, Mattner J, <strong>Wirtz S</strong>, Winner B, Neurath MF, G眉nther C. STAT1 coordinates intestinal epithelial cell death during gastrointestinal infection upstream of Caspase-8. Mucosal Immunol. 2022 Jan;15(1):130-142. doi: 10.1038/s41385-021-00450-2.</p><p> </p></div></div></div></div></div><div id="c73402" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2021</span></h2></div><p>Bittel M, Reichert P, Sarfati I, Dressel A, Leikam S, Uderhardt S, Stolzer I, Phu TA, Ng M, Vu NK, Tenzer S, Distler U, <strong>Wirtz S</strong>, Rothhammer V, Neurath MF, Raffai RL, G眉nther C, Momma S. Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo. J Extracell Vesicles. 2021 Oct;10(12):e12159. doi: 10.1002/jev2.12159.</p><p>Faas M, Ipseiz N, Ackermann J, Culemann S, Gr眉neboom A, Schr枚der F, Rothe T, Scholtysek C, Eberhardt M, B枚ttcher M, Kirchner P, Stoll C, Ekici A, Fuchs M, Kunz M, Weigmann B, <strong>Wirtz S</strong>, Lang R, Hofmann J, Vera J, Voehringer D, Michelucci A, Mougiakakos D, Uderhardt S, Schett G, Kr枚nke G. IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity. 2021 Nov 9;54(11):2531-2546.e5. doi: 10.1016/j.immuni.2021.09.010. Epub 2021 Oct 12.</p><p>Patankar JV, M眉ller TM, Kantham S, Acera MG, Mascia F, Scheibe K, Mahapatro M, Heichler C, Yu Y, Li W, Ruder B, G眉nther C, Leppkes M, Mathew MJ, <strong>Wirtz S</strong>, Neufert C, K眉hl AA, Paquette J, Jacobson K, Atreya R, Zundler S, Neurath MF, Young RN, Becker C. E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis. Nat Cell Biol. 2021 Jul;23(7):796-807. doi: 10.1038/s41556-021-00708-8. Epub 2021 Jul 8.</p><p>Lechner K, Mott S, Al-Saifi R, Knipfer L, <strong>Wirtz S</strong>, Atreya R, Vieth M, Rath T, Fraass T, Winter Z, August A, Luban J, Zimmermann VS, Weigmann B, Neurath MF. Targeting of the Tec Kinase ITK Drives Resolution of T Cell-Mediated Colitis and Emerges as Potential Therapeutic Option in Ulcerative Colitis. Gastroenterology. 2021 Oct;161(4):1270-1287.e19. doi: 10.1053/j.gastro.2021.06.072. </p><p><strong>Wirtz S</strong>, Schulz-Kuhnt A, Neurath MF, Atreya I. Functional Contribution and Targeted Migration of Group-2 Innate Lymphoid Cells in Inflammatory Lung Diseases: Being at the Right Place at the Right Time. Front Immunol. 2021 Jun 10;12:688879. doi: 10.3389/fimmu.2021.688879. </p><p>Gonzalez Acera M, Patankar JV, Diemand L, Siegmund B, Neurath MF, <strong>Wirtz S</strong>, Becker C. Comparative Transcriptomics of IBD Patients Indicates Induction of Type 2 Immunity Irrespective of the Disease Ideotype. Front Med (Lausanne). 2021 May 31;8:664045. doi: 10.3389/fmed.2021.664045.</p><p>Seiwert N, Adam J, Steinberg P, <strong>Wirtz S</strong>, Schwerdtle T, Adams-Quack P, H枚velmeyer N, Kaina B, Foersch S, Fahrer J. Chronic intestinal inflammation drives colorectal tumor formation triggered by dietary heme iron in vivo. Arch Toxicol. 2021 Jul;95(7):2507-2522. doi: 10.1007/s00204-021-03064-6. </p><p>Schulz-Kuhnt A, Neurath MF, <strong>Wirtz S</strong>, Atreya I. Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases. Front Med (Lausanne). 2021 Mar 30;8:656745. doi: 10.3389/fmed.2021.656745.</p><p>Buchele V, Konein P, Vogler T, Kunert T, Enderle K, Khan H, B眉ttner-Herold M, Lehmann CHK, Amon L, <strong>Wirtz S</strong>, Dudziak D, Neurath MF, Neufert C, Hildner K. Th17 Cell-Mediated Colitis Is Positively Regulated by Interferon Regulatory Factor 4 in a T Cell-Extrinsic Manner. Front Immunol. 2021 Jan 29;11:590893. doi: 10.3389/fimmu.2020.590893.</p><p>Kang L, Schmalzl A, Leupold T, Atreya R, Becker C, <strong>Wirtz S</strong>. CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-纬 Producing Innate Lymphoid CelIs and Protects From Experimental Colitis. Front Immunol 2021 Feb 05 <a href="https://doi.org/10.3389/fimmu.2020.609400" target="_blank" rel="noreferrer">doi.org/10.3389/fimmu.2020.609400</a></p></div></div></div></div></div><div id="c73401" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2020</span></h2></div><p class="MsoPlainText">Gamez-Belmonte R, Erkert L, <strong>Wirtz S</strong>*, Becker C*. The Regulation of Intestinal Inflammation and Cancer Development by Type 2 Immune Responses. Int J Mol Sci. 2020 Dec 21;21(24):9772. *shared authorship</p><p class="MsoPlainText">Cosma-Grigorov A, Meixner H, Mrochen A, <strong>Wirtz S</strong>, Winkler J, Marxreiter F. Changes in Gastrointestinal Microbiome Composition in PD: A Pivotal Role of Covariates. Front Neurol. 2020 Sep 23;11:1041.</p><p class="MsoPlainText">Sp盲th M, Hohmann M, Roider C, Lengenfelder B, Stelzle F, <strong>Wirtz S</strong>, Kl盲mpfl F. Towards shifted position-diffuse eflectance imaging of anatomically correctly scaled human microvasculature. Sci Rep. 2020 Oct 15;10(1):17391.</p><p class="MsoPlainText">Frech M, Knipfer L, <strong>Wirtz S</strong>, Zaiss MM. An in vivo gene delivery approach for the isolation of reasonable numbers of type 2 innate lymphoid cells. MethodsX. 2020 Sep 10;7:101054.</p><p class="MsoPlainText">Konturek PC, Konturek K, Brzozowski T, Wojcik D, Magierowski M, Targosz A, Krzysiek-Maczka G, Sliwowski Z, Strzalka M, Magierowska K, Szczyrk U, Kwiecien S, Ptak-Belowska A, Neurath M, Dieterich W, <strong>Wirtz S</strong>, Zopf Y. Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic Syngut on experimental colitis under stress conditions. J Physiol Pharmacol. 2020 Jun;71(3).</p><p class="MsoPlainText">Schapher M, Koch M, Weidner D, Scholz M, <strong>Wirtz S</strong>, Mahajan A, Herrmann I, Singh J, Knopf J, Leppkes M, Schauer C, Gr眉neboom A, Alexiou C, Schett G, Iro H, Mu帽oz LE, Herrmann M. Neutrophil Extracellular Traps Promote the Development and Growth of Human Salivary Stones. Cells. 2020 Sep 22;9(9):2139.</p><p class="MsoPlainText">Langheinrich M*, <strong>Wirtz S*</strong>, Kneis B, Gittler MM, Tyc O, Schierwagen R, Brunner M, Krautz C, Weber GF, Pilarsky C, Trebicka J, Agaimy A, Gr眉tzmann R, Kersting S. Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development. J Clin Med. 2020 Aug 28;9(9):2785. *shared authorship</p><p class="MsoPlainText">Hahn L, Helmrich N, Herebian D, Mayatepek E, Drebber U, Domann E, Olejniczak S, Weigel M, Hain T, Rath T, <strong>Wirtz S</strong>, Mollenkopf HJ, Schmidt N, Ewers C, Baier A, Churin Y, Windhorst A, Weiskirchen R, Steinhoff U, Roeb E, Roderfeld M. IL-13 as Target to Reduce Cholestasis and Dysbiosis in Abcb4 Knockout Mice. Cells. 2020 Aug 24;9(9):1949.</p><p class="MsoPlainText">Huber A, Killy B, Grummel N, Bodendorfer B, Paul S, Wiesmann V, Naschberger E, Zimmer J, <strong>Wirtz S</strong>, Schleicher U, Vera J, Ekici AB, Dalpke A, Lang R. Mycobacterial Cord Factor Reprograms the Macrophage Response to IFN-纬 towards Enhanced Inflammation yet Impaired Antigen Presentation and Expression of GBP1. J Immunol. 2020 Sep 15;205(6):1580-1592.</p><p class="MsoPlainText">Baier J, G盲nsbauer M, Giessler C, Arnold H, Muske M, Schleicher U, Lukassen S, Ekici A, Rauh M, Daniel C, Hartmann A, Schmid B, Tripal P, Dettmer K, Oefner PJ, Atreya R, <strong>Wirtz S</strong>, Bogdan C, Mattner J. Arginase impedes the resolution of colitis by altering the microbiome and metabolome. J Clin Invest. 2020 Nov 2;130(11):5703-5720.</p><p class="MsoPlainText">Schulz-Kuhnt A, <strong>Wirtz S</strong>, Neurath MF, Atreya I. Regulation of Human InnateLymphoid Cells in the Context of Mucosal Inflammation. Front Immunol. 2020 Jun 23;11:1062.</p><p class="MsoPlainText">Schulz-Kuhnt A, Greif V, Hildner K, Knipfer L, D枚br枚nti M, Zirlik S, Fuchs F, Atreya R, Zundler S, L贸pez-Posadas R, Neufert C, Ramming A, Kiefer A, Gr眉neboom A, Strasser E, <strong>Wirtz S</strong>, Neurath MF, Atreya I. ILC2 Lung-Homing in Cystic Fibrosis Patients: Functional Involvement of CCR6 and Impact on Respiratory Failure. Front Immunol. 2020 May 7;11:691.</p><p class="MsoPlainText">Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenm盲ki H, Hoxha E, <strong>Wirtz S</strong>, Huber TB, Panzer U, Turner JE. Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy. Kidney Int. 2020 Sep;98(3):615-629.</p><p class="MsoPlainText">Tajik N, Frech M, Schulz O, Sch盲lter F, Lucas S, Azizov V, D眉rholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Kr枚nke G, Luo Y, 脺berla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, <strong>Wirtz S</strong>, Ca帽ete JD, Ciccia F, Schett G, Zaiss MM. Targeting zonulin and intestinal epithelial barrier function to prevent onset of arthritis. Nat Commun. 2020 Apr 24;11(1):1995.</p><p class="MsoPlainText">Azizov V, Dietel K, Steffen F, D眉rholz K, Meidenbauer J, Lucas S, Frech M, Omata Y, Tajik N, Knipfer L, Kolenbrander A, Seubert S, Lapuente D, Sokolova MV, Hofmann J, Tenbusch M, Ramming A, Steffen U, Nimmerjahn F, Linker R, <strong>Wirtz S</strong>, Herrmann M, Temchura V, Sarter K, Schett G, Zaiss MM. Ethanol consumption inhibits TFH cell responses and the development of autoimmune arthritis. Nat Commun. 2020 Apr 24;11(1):1998.</p><p class="MsoPlainText">Pickert G, <strong>Wirtz S</strong>, Matzner J, Ashfaq-Khan M, Heck R, Rosigkeit S, Thies D,Surabatt ula R, Ehmann D, Wehkamp J, Aslam M, He G, Weiger t A, Foerster F, Klotz L, Frick JS, Becker C, Bockamp E, Schuppan D. Wheat Consumption Aggravates Colitis in Mice via Amylase Trypsin Inhibitor-mediated Dysbiosis. Gastroenterology. 2020 Jul;159(1):257-272.e17.</p><p class="MsoPlainText">Omata Y, Frech M, Lucas S, Primbs T, Knipfer L, <strong>Wirtz S</strong>, Kadono Y, Saito T, Tanaka S, Sarter K, Schett G, Zaiss MM. Type 2 innate lymphoid cells inhibit the differentiation of osteoclasts and protect from ovariectomy-induced bone loss. Bone. 2020 Jul;136:115335.</p><p class="MsoPlainText">Kindermann M, Knipfer L, Obermeyer S, M眉ller U, Alber G, Bogdan C, Schleicher U, Neurath MF, <strong>Wirtz S</strong>. Group 2 Innate Lymphoid Cells (ILC2) Suppress Beneficial Type 1 Immune Responses During Pulmonary Cryptococcosis. Front Immunol. 2020 Feb 14;11:209.</p><p class="MsoPlainText">Bittel M, Kremer AE, St眉rzl M, <strong>Wirtz S</strong>, Stolzer I, Neurath MF, Ballon G,G眉nther C. Modulation of the extrinsic cell death signaling pathway by viral Flip induces acute-death mediated liver failure. Cell Death D is. 2019 Nov 21;10(12):878.</p><p class="MsoPlainText">G枚脽wein S, Lindemann A, Mahajan A, Mauer枚der C, Martini E, Patankar J, Schett G, Becker C, <strong>Wirtz S</strong>, Naumann-Bartsch N, Bianchi ME, Greer PA, Lochnit G,Herrmann  M, Neurath MF, Leppkes M. Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation. Front Immunol. 2019 Oct 22;10:2481.</p><p class="MsoPlainText">Heichler C, Scheibe K, Schmied A, Geppert CI, Schmid B, <strong>Wirtz S</strong>, Thoma OM, Kramer V, Waldner MJ, B眉ttner C, Farin HF, Pe拧i膰 M, Knieling F, Merkel S, Gr眉neboom A, Gunzer M, Gr眉tzmann R, Rose-John S, Koralov SB, Kollias G, Vieth M, Hartmann A, Greten FR, Neurath MF, Neufert C. STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis. Gut. 2020 Jul;69(7):1269-1282.</p></div></div></div></div></div><div id="c73400" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2019</span></h2></div><p class="MsoPlainText">Koch S, Knipfer L, K枚lle J, Mirzakhani H, Graser A, Zimmermann T, Kiefer A, Melichar VO, Rascher W, Papadopoulos NG, Rieker RJ, Raby BA, Weiss ST, <strong>Wirtz S</strong>, Finotto S. Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2). Sci Rep. 2019 Oct 30;9(1):15695</p><p class="MsoPlainText">Knipfer L, Schulz-Kuhnt A, Kindermann M, Greif V, Symowski C, Voehringer D, Neurath MF, Atreya I, <strong>Wirtz S</strong>. A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 functions in type 2-mediated inflammation. J Exp Med. 2019 Dec 2;216(12):2763-2777.</p><p class="MsoPlainText">G眉nther C, Ruder B, Stolzer I, Dorner H, He GW, Chiriac MT, Aden K, Strigli A, Bittel M, Zeissig S, Rosenstiel P, Atreya R, Neurath MF, <strong>Wirtz S</strong>, Becker C. Interferon Lambda Promotes Paneth Cell Death Via STAT1 Signaling in Mice and Is Increased in Inflamed Ileal Tissues of Patients With Crohn's Disease. Gastroenterology. 2019 Nov;157(5):1310-1322.e13.</p><p class="MsoPlainText">L贸pez-Posadas R, Fastancz P, Mart铆nez-S谩nchez LDC, Panteleev-Ivlev J, Thonn V, Kisseleva T, Becker LS, Schulz-Kuhnt A, Zundler S, <strong>Wirtz S</strong>, Atreya R, Carl茅 B, Friedrich O, Sch眉rmann S, Waldner MJ, Neufert C, Brakebusch CH, Berg枚 MO, Neurath MF, Atreya I. Inhibiting PGGT1B Disrupts Function of RHOA, Resulting in T-cell Expression of Integrin 伪4尾7 and Development of Colitis in Mice. Gastroenterology. 2019 Nov;157(5):1293-1309.</p><p class="MsoPlainText">Stolzer I, Kaden-Volynets V, Ruder B, Letizia M, Bittel M, Rausch P, Basic M, Bleich A, Baines JF, Neurath MF, <strong>Wirtz S</strong>, Weidinger C, Bischoff SC, Becker C, G眉nther C. Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn's Disease-Like Inflammation. Inflamm Bowel Dis. 2020 Jan 1;26(1):66-79.</p><p class="MsoPlainText">Krljanac B, Schubart C, Naumann R, <strong>Wirtz S</strong>, Culemann S, Kr枚nke G, Voehringer D. RELM伪-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection. Sci Immunol. 2019 May 24;4(35):eaau3814.</p><p class="MsoPlainText">Schulz-Kuhnt A, Zundler S, Gr眉neboom A, Neufert C, <strong>Wirtz S</strong>, Neurath MF, Atreya I. Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy. J Vis Exp. 2019 Apr 16;(146).</p><p class="MsoPlainText">Hayek I, Fischer F, Schulze-Luehrmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, <strong>Wirtz S</strong>, Jantsch J, L眉hrmann A. Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages. Cell Rep. 2019 Mar 26;26(13):3502-3510.e6.</p><p class="MsoPlainText">Atreya I, Kindermann M, <strong>Wirtz S</strong>. Innate lymphoid cells in intestinal cancer development. Semin Immunol. 2019 Feb;41:101267.</p><p class="MsoPlainText">Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carl茅 B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Sch眉rmann S, Friedrich O, Waldner MJ, Rath T, <strong>Wirtz S</strong>, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C. Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation. Gastroenterology. 2019 Mar;156(4):1082-1097.e11.</p><p class="MsoPlainText">Dieterich W, Schuppan D, Schink M, Schwappacher R, <strong>Wirtz S</strong>, Agaimy A, Neurath MF, Zopf Y. Influence of low FODMAP and gluten-free diets on disease activity and intestinal microbiota in patients with non-celiac gluten sensitivity. Clin Nutr. 2019 Apr;38(2):697-707.</p></div></div></div></div></div><div id="c73399" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2018</span></h2></div><p class="MsoPlainText">Schink M, Konturek PC, Tietz E, Dieterich W, Pinzer TC, <strong>Wirtz S</strong>, Neurath MF, Zopf Y. Microbial patterns in patients with histamine intolerance. J Physiol Pharmacol. 2018 Aug;69(4).</p><p class="MsoPlainText">Ruder B, Murtadak V, St眉rzl M, <strong>Wirtz S</strong>, Distler U, Tenzer S, Mahapatro M, Greten FR, Hu Y, Neurath MF, Cesarman E, Ballon G, G眉nther C, Becker C. Chronic intestinal inflammation in mice expressing viral Flip in epithelial cells. Mucosal Immunol. 2018 Nov;11(6):1621-1629.</p><p class="MsoPlainText">Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Kr枚nke G, <strong>Wirtz S</strong>, Schett G, Zaiss MM. Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Cell Rep. 2018 Jul 3;24(1):169-180.</p><p class="MsoPlainText">Doebbeler M, Koenig C, Krzyzak L, Seitz C, Wild A, Ulas T, Ba脽ler K, Kopelyanskiy D, Butterhof A, Kuhnt C, Kreiser S, Stich L, Zinser E, Knippertz I, <strong>Wirtz S</strong>, Riegel C, Hoffmann P, Edinger M, Nitschke L, Winkler T, Schultze JL, Steinkasserer A, Lechmann M. CD83 expression is essential for Treg cell differentiation and stability. JCI Insight. 2018 Jun 7;3(11):e99712.</p><p class="MsoPlainText">Kindermann M, Knipfer L, Atreya I, <strong>Wirtz S</strong>. ILC2s in infectious diseases and organ-specific fibrosis. Semin Immunopathol. 2018 Jul;40(4):379-392.</p><p class="MsoPlainText">Hefele M, Stolzer I, Ruder B, He GW, Mahapatro M, <strong>Wirtz S</strong>, Neurath MF, G眉nther C. Intestinal epithelial Caspase-8 signaling is essential to prevent necroptosis during Salmonella Typhimurium induced enteritis. Mucosal Immunol. 2018 Jul;11(4):1191-1202.</p><p class="MsoPlainText">Khalil M, Alliger K, Weidinger C, Yerinde C, <strong>Wirtz S</strong>, Becker C, Engel MA. Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia. Front Immunol. 2018 Feb 7;9:174.</p><p class="MsoPlainText">Ullrich E, Abendroth B, Rothamer J, Huber C, B眉ttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, V枚lkl S, Beilhack A, Rose-John S, <strong>Wirtz S</strong>, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K. BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease. J Clin Invest. 2018 Mar 1;128(3):916-930.</p></div></div></div></div></div><div id="c73398" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2017</span></h2></div><p class="MsoPlainText">Nold-Petry CA, Nold MF, Levy O, Kliger Y, Oren A, Borukhov I, Becker C, <strong>Wirtz S</strong>, Sandhu MK, Neurath M, Dinarello CA. Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation. Front Immunol. 2017 Dec 11;8:1531.</p><p class="MsoPlainText">Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Ca帽ete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, <strong>Wirtz S</strong>, Schett G, Distler JHW, Ramming A. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med. 2017 Aug;23(8):938-944.</p><p class="MsoPlainText">Kurow O, Frey B, Schuster L, Schmitt V, Adam S, Hahn M, Gilchrist D, McInnes IB, <strong>Wirtz S</strong>, Gaipl US, Kr枚nke G, Schett G, Frey S, Hueber AJ. Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction. Front Immunol. 2017 Jun 28;8:722.</p><p class="MsoPlainText"><strong>Wirtz S</strong>, Popp V, Kindermann M, Gerlach K, Weigmann B, Fichtner-Feigl S, Neurath MF. Chemically induced mouse models of acute and chronic intestinal inflammation. Nat Protoc. 2017 Jul;12(7):1295-1309.</p><p class="MsoPlainText">Chiriac MT, Buchen B, Wandersee A, Hundorfean G, G眉nther C, Bourjau Y, Doyle SE, Frey B, Ekici AB, B眉ttner C, Weigmann B, Atreya R, <strong>Wirtz S</strong>, Becker C, Siebler J, Neurath MF. Activation of Epithelial Signal Transducer and Activator of Transcription 1 by Interleukin 28 Controls Mucosal Healing in Mice With Colitis and Is Increased in Mucosa of Patients With Inflammatory Bowel Disease. Gastroenterology. 2017 Jul;153(1):123-138.e8.</p><p class="MsoPlainText">Konturek PC, Koziel J, Dieterich W, Haziri D, <strong>Wirtz S</strong>, Glowczyk I, Konturek K, Neurath MF, Zopf Y. Successful therapy of Clostridium difficile infection with fecal microbiota transplantation. J Physiol Pharmacol. 2016 Dec;67(6):859-866.</p><p class="MsoPlainText">Hern谩ndez-Chirlaque C, G谩mez-Belmonte R, Oc贸n B, Mart铆nez-Moya P, <strong>Wirtz S</strong>, S谩nchez de Medina F, Mart铆nez-Augustin O. Tissue Non-specific Alkaline Phosphatase Expression is Needed for the Full Stimulation of T Cells and T Cell-Dependent Colitis. J Crohns Colitis. 2017 Jul 1;11(7):857-870.</p><p class="MsoPlainText">He GW, G眉nther C, Kremer AE, Thonn V, Amann K, Poremba C, Neurath MF, <strong>Wirtz S</strong>, Becker C. PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury. Gut. 2017 Apr;66(4):716-7 23.</p><p class="MsoPlainText">Mattner J, <strong>Wirtz S</strong>. Friend or Foe? The Ambiguous Role of Innate Lymphoid Cells in Cancer Development. Trends Immunol. 2017 Jan;38(1):29-38.</p><p class="MsoPlainText">Scheibe K, Backert I, <strong>Wirtz S</strong>, Hueber A, Schett G, Vieth M, Probst HC, BoppT, Neurath MF, Neufert C. IL-36R signalling activates intestinal epithelial cells and fibroblasts and promotes mucosal healing in vivo. Gut. 2017 May;66(5):823-838.</p></div></div></div></div></div><div id="c46862" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2016</span></h2></div><p class="MsoPlainText">G眉nther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, Becker C, <strong>Wirtz S</strong>. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest. 2016 Nov 1;126(11):4346-4360.</p><p class="MsoPlainText">Konturek PC, Koziel J, Dieterich W, Haziri D, <strong>Wirtz S</strong>, Glowczyk I, Konturek K, Neurath MF, Zopf Y. Successful therapy of Clostridium difficile infection with fecal microbiota transplantation. J Physiol Pharmacol. 2016 Dec;67(6):859-866.</p><p class="MsoPlainText">G眉nther C, He GW, Kremer AE, Murphy JM, Petrie EJ, Amann K, Vandenabeele P, Linkermann A, Poremba C, Schleicher U, Dewitz C, Krautwald S, Neurath MF, BeckerC, <strong>Wirtz S</strong>. The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis. J Clin Invest. 2016 Nov1;126(11):4346-4360.</p><p class="MsoPlainText">Kistner K, Siklosi N, Babes A, Khalil M, Selescu T, Zimmermann K, <strong>Wirtz S</strong>, Becker C, Neurath MF, Reeh PW, Engel MA. Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain. Sci Rep. 2016 Jun 30;6:28621.</p><p class="MsoPlainText">Danzer C, Koller A, Baier J, Arnold H, Giessler C, Opoka R, Schmidt S,Willers M, Mihai S, Parsch H, <strong>Wirtz S</strong>, Daniel C, Reinhold A, Engelmann S, Kliche S, Bogdan C, Hoebe K, Mattner J. A mutation within the SH2 domain of slp-76 regulates the tissue distribution and cytokine production of iNKT cells in mice. Eur J Immunol. 2016 Sep;46(9):2121-36. doi: 10.1002/eji.201646331. Epub 2016 Jul 29.</p><p class="MsoPlainText">Mahapatro M, Foersch S, Hefele M, He GW, Giner-Ventura E, Mchedlidze T, Kindermann M, Vetrano S, Danese S, G眉nther C, Neurath MF, <strong>Wirtz S*</strong>, Becker C*. Programming of Intestinal Epithelial Differentiation by IL-33 Derived from Pericryptal Fibroblasts in Response to Systemic Infection. Cell Rep. 2016 May 24;15(8):1743-56.*shared authorship</p><p class="MsoPlainText">Rausch P, Basic M, Batra A, Bischoff SC, Blaut M, Clavel T, Gl盲sner J, Gopalakrishnan S, Grassl GA, G眉nther C, Haller D, Hirose M, Ibrahim S, Loh G, Mattner J, Nagel S, Pabst O, Schmidt F, Siegmund B, Strowig T, Volynets V, <strong>Wirtz S</strong>, Zeissig S, Zeissig Y, Bleich A, Bain es JF. Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities. Int J Med Microbiol. 2016 Aug;306(5):343-355.</p><p class="MsoPlainText">Khalil M, Babes A, Lakra R, F枚rsch S, Reeh PW, <strong>Wirtz S</strong>, Becker C, Neurath MF, Engel MA. Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production. Mucosal Immunol. 2016 Nov;9(6):1500-1513.</p><p class="MsoPlainText">Mchedlidze T, Kindermann M, Neves AT, Voehringer D, Neurath MF, <strong>Wirtz S</strong>. IL-27 suppresses type 2 immune responses in vivo via direct effects on group 2 innate lymphoid cells. Mucosal Immunol. 2016 Nov;9(6):1384-1394.</p><p class="MsoPlainText">Leppkes M, Mauer枚der C, Hirth S, Nowecki S, G眉nther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, <strong>Wirtz S</strong>, Neurath MF, Herrmann M, Becker C. Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis. Nat Commun. 2016 Mar 11;7:10973.</p><p class="MsoPlainText">L贸pez-Posadas R, Becker C, G眉nther C, Tenzer S, Amann K, Billmeier U, Atreya R, Fiorino G, Vetrano S, Danese S, Ekici AB, <strong>Wirtz S</strong>, Thonn V, Watson AJ, Brakebusch C, Berg枚 M, Neurath MF, Atreya I. Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation. J Clin Invest. 2016 Feb;126(2):611-26.</p></div></div></div></div></div><div id="c13283" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2015</span></h2></div><p>Luo Y, Chen GL, Hannemann N, Ipseiz N, Kr枚nke G, B盲uerle T, Munos L, Wirtz S, Schett G, Bozec A. Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche. Cell Metab. 2015 Nov 3;22(5):886-94. doi: 10.1016/j.cmet.2015.08.020. Epub 2015 Sep 17. PMID: 26387866 </p><p>Haep L, Britzen-Laurent N, Weber TG, Naschberger E, Schaefer A, Kremmer E, Foersch S, Vieth M, Scheuer W, Wirtz S, Waldner M, St眉rzl M. Interferon Gamma Counteracts the Angiogenic Switch and Induces Vascular Permeability in Dextran Sulfate Sodium Colitis in Mice. Inflamm Bowel Dis. 2015 Oct;21(10):2360-71. doi: 10.1097/MIB.00000000000004 PMID: 26164664 </p><p>Niedzielska M, Raffi FA, Tel J, Muench S, Jozefowski K, Alati N, Lahl K, Mages J, Billmeier U, Schiemann M, Appelt UK, Wirtz S, Sparwasser T, Hochrein H, Figdor CG, Keyse SM, Lang R. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-尾 Production. J Immunol. 2015 Aug 15;195(4):1753-62. doi: 10.4049/jimmunol.1400658. Epub 2015 Jul 13. PMID: 26170386 </p><p>Becker C., Neurath M.F., Wirtz S, The microbiota in inflammatory bowel disease. ILAR in press </p><p>Wittkopf N, Pickert G, Billmeier U, Mahapatro M, Wirtz S, Martini E, Leppkes M, Neurath MF, Becker C. Activation of intestinal epithelial Stat3 orchestrates tissue defense during gastrointestinal infection. PLoS One. 2015 Mar 23;10(3) </p><p>Foersch S, Sperka T, Lindner C, Taut A, Rudolph KL, Breier G, Boxberger F, Rau TT, Hartmann A, St眉rzl M, Wittkopf N, Haep L, Wirtz S, Neurath MF, Waldner MJ. VEGFR2 Signaling Prevents Colorectal Cancer Cell Senescence to Promote Tumorigenesis in Mice With Colitis. Gastroenterology. 2015 Jul;149(1):177-189</p></div></div></div></div></div><div id="c13284" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2014</span></h2></div><p> Shen P, Roch T, Lampropoulou V, O'Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Gr眉tzkau A, Gr眉n JR, Horn K, K眉hl AA, D枚rner T, Bar-Or A, Kaufmann SH, Anderton SM, Fillatreau S. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature. 2014 Mar 20;507(7492):366-70. </p><p>Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, Lehr HA, Wirtz S, Vieth M, Waisman A, Rosenbauer F, McKenzie AN, Weigmann B, Neurath MF. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol. 2014 Jul;15(7):676-86. </p><p>Backert I, Koralov SB, Wirtz S, Kitowski V, Billmeier U, Martini E, Hofmann K, Hildner K, Wittkopf N, Brecht K, Waldner M, Rajewsky K, Neurath MF, Becker C, Neufert C. STAT3 activation in Th17 and Th22 cells controls IL-22-mediated epithelial host defense during infectious colitis.  J Immunol. 2014 Oct 1;193(7):3779-91. </p><p>Zenker S, Panteleev-Ivlev J, Wirtz S, Kishimoto T, Waldner MJ, Ksionda O, Tybulewicz VL, Neurath MF, Atreya I. A key regulatory role for Vav1 in controlling lipopolysaccharide endotoxemia via macrophage-derived IL-6.  J Immunol. 2014 Mar 15;192(6):2830-6.</p></div></div></div></div></div><div id="c13285" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>2013</span></h2></div><p>McHedlidze T, Waldner M, Zopf S, Walker J, Rankin AL, Schuchmann M, Voehringer D, McKenzie AN, Neurath MF, Pflanz S, Wirtz S. Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis. Immunity. 2013 Aug 22;39(2):357-71. </p><p>Stock M, B枚hm C, Scholtysek C, Englbrecht M, F眉rnrohr BG, Klinger P, Gelse K, Gayetskyy S, Engelke K, Billmeier U, Wirtz S, van den Berg W, Schett G. Wnt inhibitory factor 1 deficiency uncouples cartilage and bone destruction in tumor necrosis factor 伪-mediated experimental arthritis. Arthritis Rheum. 2013 Sep;65(9):2310-22. </p><p>Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, Egger G, Mayr A, Oberhollenzer F, Kronenberg F, Orthofer M, Penninger JM, Meigs JB, Bonora E, Tilg H, Willeit J, Schett G. Blockade of receptor activator of nuclear factor-魏B (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 2013 Mar;19(3):358-63. </p><p>Desel C, Werninghaus K, Ritter M, Jozefowski K, Wenzel J, Russkamp N, Schleicher U, Christensen D, Wirtz S, Kirschning C, Agger EM, Prazeres da Costa C, Lang R. The Mincle-activating adjuvant TDB induces MyD88-dependent Th1 and Th17 responses through IL-1R signaling. PLoS One. 2013;8(1) </p><p>Lin NY, Beyer C, Giessl A, Kireva T, Scholtysek C, Uderhardt S, Munoz LE, Dees C, Distler A, Wirtz S, Kr枚nke G, Spencer B, Distler O, Schett G, Distler JH. Autophagy regulates TNF伪-mediated joint destruction in experimental arthritis. Ann Rheum Dis. 2013 May;72(5):761-8.</p></div></div></div></div></div><div id="c46863" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>脛ltere Publikationen</span></h2></div><p>Dornhoff H, Becker C, Wirtz S, Strand D, Tenzer S, Rosfa S, Neufert C, Mudter J, Markl J, Siebler J, Neurath MF. A variant of Smurf2 protects mice against colitis-associated colon cancer by inducing transforming growth factor 尾 signaling. Gastroenterology. 2012 May;142(5):1183-1194.e4. doi: 10.1053/j.gastro.2012.02.005. Epub 2012 Feb 11. PMID: 22333948 </p><p>Wirtz S, Billmeier U, Mchedlidze T, Blumberg RS, Neurath MF. Interleukin-35 mediates mucosal immune responses that protect against T-cell-dependent colitis. Gastroenterology. 2011 Nov;141(5):1875-86. doi: 10.1053/j.gastro.2011.07.040. Epub 2011 Aug PMID: 21820391 </p><p>Waldner MJ, Wirtz S, Neufert C, Becker C, Neurath MF. Confocal laser endomicroscopy and narrow-band imaging-aided endoscopy for in vivo imaging of colitis and colon cancer in mice. Nat Protoc. 2011 Sep 1;6(9):1471-81. doi: 10.1038/nprot.2011.377. PMID: 21886109 </p><p>Mudter J, Yu J, Zufferey C, Br眉stle A, Wirtz S, Weigmann B, Hoffman A, Schenk M, Galle PR, Lehr HA, Mueller C, Lohoff M, Neurath MF. IRF4 regulates IL-17A promoter activity and controls ROR纬t-dependent Th17 colitis in vivo. Inflamm Bowel Dis. 2011 Jun;17(6):1343-58. doi: 10.1002/ibd.21476. Epub 2011 Feb 8. PMID: 21305677 </p><p>Waldner MJ, Wirtz S, Jefremow A, Warntjen M, Neufert C, Atreya R, Becker C, Weigmann B, Vieth M, Rose-John S, Neurath MF. VEGF receptor signaling links inflammation and tumorigenesis in colitis-associated cancer. J Exp Med. 2010 Dec 20;207(13):2855-68. doi: 10.1084/jem.20100438. Epub 2010 Nov 22. PMID: 21098094 </p><p>Wirtz S, Nagel G, Eshkind L, Neurath MF, Samson LD, Kaina B. Both base excision repair and O6-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis. Carcinogenesis. 2010 Dec;31(12):2111-7. doi: 10.1093/carcin/bgq174. Epub 2010 Aug 23. PMID: 20732909 </p><p>Neurath MF, Wittkopf N, Wlodarski A, Waldner M, Neufert C, Wirtz S, G眉nther C, Becker C. Assessment of tumor development and wound healing using endoscopic techniques in mice. Gastroenterology. 2010 Dec;139(6):1837-1843.e1. doi: 10.1053/j.gastro.2010.10.007. Epub 2010 Oct PMID: 20955705 </p><p>Waldner MJ, Wirtz S, Becker C, Seidel D, Tubbe I, Cappel K, H盲hnel PS, Galle PR, Schuler M, Neurath MF. Perforin deficiency attenuates inflammation and tumor growth in colitis-associated cancer. Inflamm Bowel Dis. 2010 Apr;16(4):559-67. doi: 10.1002/ibd.21107. PMID: 19785028 </p><p>Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA, Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J Exp Med. 2009 Jul 6;206(7):1465-72. doi: 10.1084/jem.20082683. Epub 2009 Jun 29. PMID: 19564350 </p><p>Leppkes M, Becker C, Ivanov II, Hirth S, Wirtz S, Neufert C, Pouly S, Murphy AJ, Valenzuela DM, Yancopoulos GD, Becher B, Littman DR, Neurath MF. RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 2009 Jan;136(1):257-67. doi: 10.1053/j.gastro.2008.10.018. Epub 2008 Oct PMID: 18992745 </p><p>Mudter J, Amoussina L, Schenk M, Yu J, Br眉stle A, Weigmann B, Atreya R, Wirtz S, Becker C, Hoffman A, Atreya I, Biesterfeld S, Galle PR, Lehr HA, Rose-John S, Mueller C, Lohoff M, Neurath MF. The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6. J Clin Invest. 2008 Jul;118(7):2415-26. doi: 10.1172/JCI33227. PMID: 18535667 </p><p>Siebler J, Wirtz S, Frenzel C, Schuchmann M, Lohse AW, Galle PR, Neurath MF. Cutting edge: a key pathogenic role of IL-27 in T cell- mediated Hepatitis. J Immunol. 2008 Jan 1;180(1):30 PMID: 18096999 </p><p>Atreya I, Schimanski CC, Becker C, Wirtz S, Dornhoff H, Schn眉rer E, Berger MR, Galle PR, Herr W, Neurath MF. The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. Gut. 2007 Nov;56(11):1572-8. Epub 2007 Jun PMID: 17566017 </p><p>Wirtz S, Neurath MF. Mouse models of inflammatory bowel disease. Adv Drug Deliv Rev. 2007 Sep 30;59(11):1073-83. Epub 2007 Aug 16. Review. PMID: 17825455 </p><p>Neufert C, Becker C, Wirtz S, Fantini MC, Weigmann B, Galle PR, Neurath MF. IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1. Eur J Immunol. 2007 Jul;37(7):1809-16. PMID: 17549733 </p><p>Hildner KM, Schirmacher P, Atreya I, Dittmayer M, Bartsch B, Galle PR, Wirtz S, Neurath MF. Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced Arthritis. J Immunol. 2007 Mar 15;178(6):3427-36. PMID: 17339437 </p><p>Siebler J, Wirtz S, Weigmann B, Atreya I, Schmitt E, Kreft A, Galle PR, Neurath MF. IL-28A is a key regulator of T-cell-mediated liver injury via the T-box transcription factor T-bet. Gastroenterology. 2007 Jan;132(1):358-71. Epub 2006 Oct 21. PMID: 17241885 </p><p>Wirtz S, Neufert C, Weigmann B, Neurath MF. Chemically induced mouse models of intestinal Inflammation. Nat Protoc. 2007;2(3):541 PMID: 17406617 </p><p>Becker C, Dornhoff H, Neufert C, Fantini MC, Wirtz S, Huebner S, Nikolaev A, Lehr HA, Murphy AJ, Valenzuela DM, Yancopoulos GD, Galle PR, Karow M, Neurath MF. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol. 2006 Sep 1;177(5):2760 PMID: 16920909 </p><p>Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med. 2006 Aug 7;203(8):1875-81. Epub 2006 Jul PMID: 16880260 </p><p>Mudter J, Wirtz S, Weigmann B, Tiede I, Tubbe I, Kiesslich R, Galle PR, Lehr HA, Neurath MF. Crohn's-like colitis in a patient with immunodeficiency associated with a defect in expression of inducible costimulator. Dig Dis Sci. 2006 Apr;51(4):711-7. No abstract available. PMID: 16614993 </p><p>Wirtz SP, Schmidt C, Van Aken H, Brodner G, Hammel D, Scheld HH, Berendes E. Temporary right heart support with percutaneous jugular Access. Ann Thorac Surg. 2006 Feb;81(2):701-5. PMID: 16427877 </p><p>Siebler J, Protzer U, Wirtz S, Schuchmann M, H枚hler T, Galle PR, Neurath MF. Overexpression of STAT-1 by adenoviral gene transfer does not inhibit hepatitis B virus replication. Eur J Gastroenterol Hepatol. 2006 Feb;18(2):167-PMID: 16394798 </p><p>Poppe D, Tiede I, Fritz G, Becker C, Bartsch B, Wirtz S, Strand D, Tanaka S, Galle PR, Bustelo XR, Neurath MF. Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins. J Immunol. 2006 Jan 1;176(1):640-51. PMID: 16365460 </p><p>Becker C, Wirtz S, Neurath MF. Stepwise regulation of TH1 responses in autoimmunity: IL-12-related cytokines and their receptors. Inflamm Bowel Dis. 2005 Aug;11(8):755-64. Review. PMID: 16043992 </p><p>Schmidt C, Hinder F, Van Aken H, Theilmeier G, Bruch C, Wirtz SP, B眉rkle H, G眉hs T, Rothenburger M, Berendes E. The effect of high thoracic epidural anesthesia on systolic and diastolic left ventricular function in patients with coronary artery disease. Anesth Analg. 2005 Jun;100(6):1561 PMID: 15920175 </p><p>Zahn S, Wirtz S, Birkenbach M, Blumberg RS, Neurath MF, von Stebut E. Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major. Eur J Immunol. 2005 Apr;35(4):1106-12. PMID: 15756639 </p><p>Wirtz S, Neurath MF. Illuminating the role of type I IFNs in colitis.J Clin Invest. 2005 Mar;115(3):586 PMID: 15765141 </p><p>Wirtz S, Becker C, Fantini MC, Nieuwenhuis EE, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF. EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. J Immunol. 2005 Mar 1;174(5):2814-24 PMID: 15728491 </p><p>Becker C, Fantini MC, Schramm C, Lehr HA, Wirtz S, Nikolaev A, Burg J, Strand S, Kiesslich R, Huber S, Ito H, Nishimoto N, Yoshizaki K, Kishimoto T, Galle PR, Blessing M, Rose-John S, Neurath MF. TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling.Immunity. 2004 Oct;21(4):491-5 PMID: 15485627 </p><p>Siebler J, Wirtz S, Klein S, Protschka M, Blessing M, Galle PR, Neurath MF. A key pathogenic role for the STAT1/T-bet signaling pathway in T-cell-mediated liver Inflammation. Hepatology. 2003 Dec;38(6):1573-80. PMID: 14647068 </p><p>Wirtz S, Neurath MF. Inflammatory bowel disorders: gene therapy Solutions. Curr Opin Mol Ther. 2003 Oct;5(5):495-502. Review. PMID: 14601518 </p><p>Becker C, Wirtz S, Blessing M, Pirhonen J, Strand D, Bechthold O, Frick J, Galle PR, Autenrieth I, Neurath MF. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest. 2003 Sep;112(5):693-706. PMID: 12952918 </p><p>Tiede I, Fritz G, Strand S, Poppe D, Dvorsky R, Strand D, Lehr HA, Wirtz S, Becker C, Atreya R, Mudter J, Hildner K, Bartsch B, Holtmann M, Blumberg R, Walczak H, Iven H, Galle PR, Ahmadian MR, Neurath MF. CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+ T lymphocytes. J Clin Invest. 2003 Apr;111(8):1133-45 PMID: 12697733 </p><p>Nieuwenhuis EE, Neurath MF, Corazza N, Iijima H, Trgovcich J, Wirtz S, Glickman J, Bailey D, Yoshida M, Galle PR, Kronenberg M, Birkenbach M, Blumberg RS. Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16951-6. Epub 2002 Dec 13. PMID: 12482940 </p><p>Wirtz SP, Schmidt C, Hammel D, Hoffmeier A, Berendes E. Crossing atrial thrombus in a patient with recurrent pulmonary embolism. Crit Care Med. 2002 Aug;30(8):1902-5. PMID: 12163814 </p><p>Wirtz S, Becker C, Blumberg R, Galle PR, Neurath MF. Treatment of T cell-dependent experimental colitis in SCID mice by local administration of an adenovirus expressing IL-18 antisense mRNA. J Immunol. 2002 Jan 1;168(1):411-20. Erratum in: J Immunol 2002 Apr 1;168(7):3683. PMID: 11751987 </p><p>Mudter J, Wirtz S, Galle PR, Neurath MF. A new model of chronic colitis in SCID mice induced by adoptive transfer of CD62L+ CD4+ T cells: insights into the regulatory role of interleukin-6 on apoptosis. Pathobiology. 2002-2003;70(3):170-6. 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