CINXE.COM
404 not found | Alnylam
<!DOCTYPE html> <html lang="en" dir="ltr" prefix="content: http://purl.org/rss/1.0/modules/content/ dc: http://purl.org/dc/terms/ foaf: http://xmlns.com/foaf/0.1/ og: http://ogp.me/ns# rdfs: http://www.w3.org/2000/01/rdf-schema# schema: http://schema.org/ sioc: http://rdfs.org/sioc/ns# sioct: http://rdfs.org/sioc/types# skos: http://www.w3.org/2004/02/skos/core# xsd: http://www.w3.org/2001/XMLSchema# "> <head> <meta charset="utf-8" /><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]},distributed_tracing:{enabled:true}};(window.NREUM||(NREUM={})).loader_config={agentID:"594347381",accountID:"3515357",trustKey:"66686",xpid:"VwMGVFVWDxAFXFFVDwcHX10=",licenseKey:"NRJS-87ce296e2989ccd0104",applicationID:"580786099"};;/*! For license information please see nr-loader-spa-1.274.0.min.js.LICENSE.txt */ (()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{Vp:()=>c,fn:()=>s,x1:()=>u});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0},a={};function s(e){try{const t=c(e);return!!t.licenseKey&&!!t.errorBeacon&&!!t.applicationID}catch(e){return!1}}function c(e){if(!e)throw new Error("All info objects require an agent identifier!");if(!a[e])throw new Error("Info for ".concat(e," was never set"));return a[e]}function u(e,t){if(!e)throw new Error("All info objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.info=a[e])}},9417:(e,t,r)=>{"use strict";r.d(t,{D0:()=>h,gD:()=>g,xN:()=>p});var n=r(993);const i=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var o=r(2614),a=r(944),s=r(384),c=r(8122);const u="[data-nr-mask]",d=()=>{const e={mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,harvestTimeSeconds:10,autoStart:!0},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},feature_flags:[],generic_events:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},harvest:{tooManyRequestsDelay:60},jserrors:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},logging:{enabled:!0,harvestTimeSeconds:10,autoStart:!0,level:n.p_.INFO},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,harvestTimeSeconds:30,autoStart:!0},performance:{capture_marks:!1,capture_measures:!1},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:o.wk,inactiveMs:o.BB},session_replay:{autoStart:!0,enabled:!1,harvestTimeSeconds:60,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){i(t)?e.mask_selector="".concat(t,",").concat(u):""===t||null===t?e.mask_selector=u:(0,a.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){i(t)?e.block_selector+=",".concat(t):""!==t&&(0,a.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,a.R)(7,t)}},session_trace:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},soft_navigations:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},spa:{enabled:!0,harvestTimeSeconds:10,autoStart:!0},ssl:void 0,user_actions:{enabled:!0}}},l={},f="All configuration objects require an agent identifier!";function h(e){if(!e)throw new Error(f);if(!l[e])throw new Error("Configuration for ".concat(e," was never set"));return l[e]}function p(e,t){if(!e)throw new Error(f);l[e]=(0,c.a)(t,d());const r=(0,s.nY)(e);r&&(r.init=l[e])}function g(e,t){if(!e)throw new Error(f);var r=h(e);if(r){for(var n=t.split("."),i=0;i<n.length-1;i++)if("object"!=typeof(r=r[n[i]]))return;r=r[n[n.length-1]]}return r}},5603:(e,t,r)=>{"use strict";r.d(t,{a:()=>c,o:()=>s});var n=r(384),i=r(8122);const o={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},a={};function s(e){if(!e)throw new Error("All loader-config objects require an agent identifier!");if(!a[e])throw new Error("LoaderConfig for ".concat(e," was never set"));return a[e]}function c(e,t){if(!e)throw new Error("All loader-config objects require an agent identifier!");a[e]=(0,i.a)(t,o);const r=(0,n.nY)(e);r&&(r.loader_config=a[e])}},3371:(e,t,r)=>{"use strict";r.d(t,{V:()=>f,f:()=>l});var n=r(8122),i=r(384),o=r(6154),a=r(9324);let s=0;const c={buildEnv:a.F3,distMethod:a.Xs,version:a.xv,originTime:o.WN},u={customTransaction:void 0,disabled:!1,isolatedBacklog:!1,loaderType:void 0,maxBytes:3e4,onerror:void 0,ptid:void 0,releaseIds:{},appMetadata:{},session:void 0,denyList:void 0,timeKeeper:void 0,obfuscator:void 0},d={};function l(e){if(!e)throw new Error("All runtime objects require an agent identifier!");if(!d[e])throw new Error("Runtime for ".concat(e," was never set"));return d[e]}function f(e,t){if(!e)throw new Error("All runtime objects require an agent identifier!");d[e]={...(0,n.a)(t,u),...c},Object.hasOwnProperty.call(d[e],"harvestCount")||Object.defineProperty(d[e],"harvestCount",{get:()=>++s});const r=(0,i.nY)(e);r&&(r.runtime=d[e])}},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.274.0",i="PROD",o="CDN",a="^2.0.0-alpha.17"},6154:(e,t,r)=>{"use strict";r.d(t,{A4:()=>s,OF:()=>d,RI:()=>i,WN:()=>h,bv:()=>o,gm:()=>a,lR:()=>f,m:()=>u,mw:()=>c,sb:()=>l});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s="complete"===a?.document?.readyState,c=Boolean("hidden"===a?.document?.visibilityState),u=""+a?.location,d=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),l=d&&"undefined"==typeof SharedWorker,f=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),h=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>c,Ze:()=>l,x3:()=>u});var n=r(7836),i=r(3606),o=r(860),a=r(2646);const s={};function c(e,t){const r={staged:!1,priority:o.P3[t]||0};d(e),s[e].get(t)||s[e].set(t,r)}function u(e,t){e&&s[e]&&(s[e].get(t)&&s[e].delete(t),h(e,t,!1),s[e].size&&f(e))}function d(e){if(!e)throw new Error("agentIdentifier required");s[e]||(s[e]=new Map)}function l(e="",t="feature",r=!1){if(d(e),!e||!s[e].get(t)||r)return h(e,t);s[e].get(t).staged=!0,f(e)}function f(e){const t=Array.from(s[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{s[e].delete(t),h(e,t)})))}function h(e,t,r=!0){const o=e?n.ee.get(e):n.ee,s=i.i.handlers;if(!o.aborted&&o.backlog&&s){if(r){const e=o.backlog[t],r=s[t];if(r){for(let t=0;e&&t<e.length;++t)p(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof a.y&&t[0].on(e,t[1])}))}))}}o.isolatedBacklog||delete s[t],o.backlog[t]=null,o.emit("drain-"+t,[])}}function p(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>c,ee:()=>u});var n=r(384),i=r(8990),o=r(3371),a=r(2646),s=r(5607);const c="nr@context:".concat(s.W),u=function e(t,r){var n={},s={},d={},l=!1;try{l=16===r.length&&(0,o.f)(r).isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(u.aborted&&!i)return;t&&o&&t.emit(e,r,n);for(var a=h(n),c=g(e),d=c.length,l=0;l<d;l++)c[l].apply(a,r);var p=v()[s[e]];p&&p.push([f,e,r,a]);return a},get:m,listeners:g,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{s[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[s[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof a.y?e:e?(0,i.I)(e,c,(()=>new a.y(c))):new a.y(c)}function p(e,t){n[e]=g(e).concat(t)}function g(e){return n[e]||[]}function m(t){return d[t]=d[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),d=(0,n.Zm)();d.ee||(d.ee=u)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>u});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function u(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";function n(e,t){"function"==typeof console.debug&&console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t)}r.d(t,{R:()=>n})},5284:(e,t,r)=>{"use strict";r.d(t,{t:()=>c,B:()=>s});var n=r(7836),i=r(6154);const o="newrelic";const a=new Set,s={};function c(e,t){const r=n.ee.get(t);s[t]??={},e&&"object"==typeof e&&(a.has(t)||(r.emit("rumresp",[e]),s[t]=e,a.add(t),function(e={}){try{i.gm.dispatchEvent(new CustomEvent(o,{detail:e}))}catch(e){}}({loaded:!0})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>d,Zm:()=>a,bQ:()=>c,dV:()=>s,nY:()=>u,pV:()=>l});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e){let t=a();return t.initializedAgents?.[e]}function d(e,t){a()[e]=t}function l(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,u="addEventListener",d="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[u,d],"-",p)}function p(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),h(a.gm,f),h(c.prototype,f)),t.on(u+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(d+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,u);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);try{return l=t.apply(a,o)}catch(e){throw i(r+"err",[o,a,e],d,c),e}finally{i(r+"end",[o,a,l],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,Zp:()=>i,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{ET:()=>o,TZ:()=>a,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o="log",a=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>u});var n=r(9908),i=r(1863),o=r(860),a=r(3969),s=r(993);function c(e,t,r={},c=s.p_.INFO){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[(0,i.t)(),t,r,c],void 0,o.K7.logging,e)}function u(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},3969:(e,t,r)=>{"use strict";r.d(t,{TZ:()=>n,XG:()=>s,rs:()=>i,xV:()=>a,z_:()=>o});const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>d,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>u,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",REPLAY_RUNNING:"replayRunning",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},u={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},d=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>c,CT:()=>u,SR:()=>s});var n=r(384),i=r(9417),o=r(7767),a=r(6154);function s(e){return!!(0,n.dV)().o.MO&&(0,o.V)(e)&&!0===(0,i.gD)(e,"session_trace.enabled")}function c(e){return!0===(0,i.gD)(e,"session_replay.preload")&&s(e)}function u(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:a.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(a.WN-t.correctedOriginTime)}}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>u,Rz:()=>d,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState",l=1e3},3962:(e,t,r)=>{"use strict";r.d(t,{AM:()=>o,O2:()=>s,Qu:()=>c,TZ:()=>a,ih:()=>u,tC:()=>i});var n=r(860);const i=["click","keydown","submit"],o="api",a=n.K7.softNav,s={INITIAL_PAGE_LOAD:"",ROUTE_CHANGE:1,UNSPECIFIED:2},c={INTERACTION:1,AJAX:2,CUSTOM_END:3,CUSTOM_TRACER:4},u={IP:"in progress",FIN:"finished",CAN:"cancelled"}},7378:(e,t,r)=>{"use strict";r.d(t,{$p:()=>x,BR:()=>b,Kp:()=>R,L3:()=>y,Lc:()=>c,NC:()=>o,SG:()=>d,TZ:()=>i,U6:()=>p,UT:()=>m,d3:()=>w,dT:()=>f,e5:()=>A,gx:()=>v,l9:()=>l,oW:()=>h,op:()=>g,rw:()=>u,tH:()=>E,uP:()=>s,wW:()=>T,xq:()=>a});var n=r(384);const i=r(860).K7.spa,o=["click","submit","keypress","keydown","keyup","change"],a=999,s="fn-start",c="fn-end",u="cb-start",d="api-ixn-",l="remaining",f="interaction",h="spaNode",p="jsonpNode",g="fetch-start",m="fetch-done",v="fetch-body-",b="jsonp-end",y=(0,n.dV)().o.ST,w="-start",R="-end",x="-body",T="cb"+R,A="jsTime",E="fetch"},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>o});var n=r(9417),i=r(6154);const o=e=>i.RI&&!0===(0,n.gD)(e,"privacy.cookies_enabled")},425:(e,t,r)=>{"use strict";r.d(t,{j:()=>j});var n=r(860),i=r(2555),o=r(3371),a=r(9908),s=r(7836),c=r(1687),u=r(5289),d=r(6154),l=r(944),f=r(3969),h=r(384),p=r(6344);const g=["setErrorHandler","finished","addToTrace","addRelease","addPageAction","setCurrentRouteName","setPageViewName","setCustomAttribute","interaction","noticeError","setUserId","setApplicationVersion","start",p.G4.RECORD,p.G4.PAUSE,"log","wrapLogger"],m=["setErrorHandler","finished","addToTrace","addRelease"];var v=r(1863),b=r(2614),y=r(993),w=r(3785),R=r(2646),x=r(3434);function T(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||s.ee).get("logger")}(e),o=(0,x.YM)(i),a=new R.y(s.P);return a.level=n.level,a.customAttributes=n.customAttributes,o.inPlace(t,[r],"wrap-logger-",a),i}function A(){const e=(0,h.pV)();g.forEach((t=>{e[t]=(...r)=>function(t,...r){let n=[];return Object.values(e.initializedAgents).forEach((e=>{e&&e.api?e.exposed&&e.api[t]&&n.push(e.api[t](...r)):(0,l.R)(38,t)})),n.length>1?n:n[0]}(t,...r)}))}const E={};var S=r(9417),N=r(5603),O=r(5284);const _=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};let I=!1;function j(e,t={},g,R){let{init:x,info:j,loader_config:P,runtime:C={},exposed:k=!0}=t;C.loaderType=g;const L=(0,h.pV)();j||(x=L.init,j=L.info,P=L.loader_config),(0,S.xN)(e.agentIdentifier,x||{}),(0,N.a)(e.agentIdentifier,P||{}),j.jsAttributes??={},d.bv&&(j.jsAttributes.isWorker=!0),(0,i.x1)(e.agentIdentifier,j);const H=(0,S.D0)(e.agentIdentifier),D=[j.beacon,j.errorBeacon];I||(H.proxy.assets&&(_(H.proxy.assets),D.push(H.proxy.assets)),H.proxy.beacon&&D.push(H.proxy.beacon),A(),(0,h.US)("activatedFeatures",O.B),e.runSoftNavOverSpa&&=!0===H.soft_navigations.enabled&&H.feature_flags.includes("soft_nav")),C.denyList=[...H.ajax.deny_list||[],...H.ajax.block_internal?D:[]],C.ptid=e.agentIdentifier,(0,o.V)(e.agentIdentifier,C),e.ee=s.ee.get(e.agentIdentifier),void 0===e.api&&(e.api=function(e,t,h=!1){t||(0,c.Ak)(e,"api");const g={};var R=s.ee.get(e),x=R.get("tracer");E[e]=b.g.OFF,R.on(p.G4.REPLAY_RUNNING,(t=>{E[e]=t}));var A="api-",S=A+"ixn-";function N(t,r,n,o){const a=(0,i.Vp)(e);return null===r?delete a.jsAttributes[t]:(0,i.x1)(e,{...a,jsAttributes:{...a.jsAttributes,[t]:r}}),I(A,n,!0,o||null===r?"session":void 0)(t,r)}function O(){}g.log=function(e,{customAttributes:t={},level:r=y.p_.INFO}={}){(0,a.p)(f.xV,["API/log/called"],void 0,n.K7.metrics,R),(0,w.R)(R,e,t,r)},g.wrapLogger=(e,t,{customAttributes:r={},level:i=y.p_.INFO}={})=>{(0,a.p)(f.xV,["API/wrapLogger/called"],void 0,n.K7.metrics,R),T(R,e,t,{customAttributes:r,level:i})},m.forEach((e=>{g[e]=I(A,e,!0,"api")})),g.addPageAction=I(A,"addPageAction",!0,n.K7.genericEvents),g.setPageViewName=function(t,r){if("string"==typeof t)return"/"!==t.charAt(0)&&(t="/"+t),(0,o.f)(e).customTransaction=(r||"http://custom.transaction")+t,I(A,"setPageViewName",!0)()},g.setCustomAttribute=function(e,t,r=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof t)||null===t)return N(e,t,"setCustomAttribute",r);(0,l.R)(40,typeof t)}else(0,l.R)(39,typeof e)},g.setUserId=function(e){if("string"==typeof e||null===e)return N("enduser.id",e,"setUserId",!0);(0,l.R)(41,typeof e)},g.setApplicationVersion=function(e){if("string"==typeof e||null===e)return N("application.version",e,"setApplicationVersion",!1);(0,l.R)(42,typeof e)},g.start=()=>{try{(0,a.p)(f.xV,["API/start/called"],void 0,n.K7.metrics,R),R.emit("manual-start-all")}catch(e){(0,l.R)(23,e)}},g[p.G4.RECORD]=function(){(0,a.p)(f.xV,["API/recordReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.RECORD,[],void 0,n.K7.sessionReplay,R)},g[p.G4.PAUSE]=function(){(0,a.p)(f.xV,["API/pauseReplay/called"],void 0,n.K7.metrics,R),(0,a.p)(p.G4.PAUSE,[],void 0,n.K7.sessionReplay,R)},g.interaction=function(e){return(new O).get("object"==typeof e?e:{})};const _=O.prototype={createTracer:function(e,t){var r={},i=this,o="function"==typeof t;return(0,a.p)(f.xV,["API/createTracer/called"],void 0,n.K7.metrics,R),h||(0,a.p)(S+"tracer",[(0,v.t)(),e,r],i,n.K7.spa,R),function(){if(x.emit((o?"":"no-")+"fn-start",[(0,v.t)(),i,o],r),o)try{return t.apply(this,arguments)}catch(e){const t="string"==typeof e?new Error(e):e;throw x.emit("fn-err",[arguments,this,t],r),t}finally{x.emit("fn-end",[(0,v.t)()],r)}}}};function I(e,t,r,i){return function(){return(0,a.p)(f.xV,["API/"+t+"/called"],void 0,n.K7.metrics,R),i&&(0,a.p)(e+t,[(0,v.t)(),...arguments],r?null:this,i,R),r?void 0:this}}function j(){r.e(478).then(r.bind(r,8778)).then((({setAPI:t})=>{t(e),(0,c.Ze)(e,"api")})).catch((e=>{(0,l.R)(27,e),R.abort()}))}return["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((e=>{_[e]=I(S,e,void 0,h?n.K7.softNav:n.K7.spa)})),g.setCurrentRouteName=h?I(S,"routeName",void 0,n.K7.softNav):I(A,"routeName",!0,n.K7.spa),g.noticeError=function(t,r){"string"==typeof t&&(t=new Error(t)),(0,a.p)(f.xV,["API/noticeError/called"],void 0,n.K7.metrics,R),(0,a.p)("err",[t,(0,v.t)(),!1,r,!!E[e]],void 0,n.K7.jserrors,R)},d.RI?(0,u.GG)((()=>j()),!0):j(),g}(e.agentIdentifier,R,e.runSoftNavOverSpa)),void 0===e.exposed&&(e.exposed=k),I=!0}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>o,K7:()=>n,P3:()=>i});const n={ajax:"ajax",genericEvents:"generic_events",jserrors:"jserrors",logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},i={[n.pageViewEvent]:1,[n.pageViewTiming]:2,[n.metrics]:3,[n.jserrors]:4,[n.spa]:5,[n.ajax]:6,[n.sessionTrace]:7,[n.softNav]:8,[n.sessionReplay]:9,[n.logging]:10,[n.genericEvents]:11},o={[n.pageViewTiming]:"events",[n.ajax]:"events",[n.spa]:"events",[n.softNav]:"events",[n.metrics]:"jserrors",[n.jserrors]:"jserrors",[n.sessionTrace]:"browser/blobs",[n.sessionReplay]:"browser/blobs",[n.logging]:"browser/logs",[n.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({212:"nr-spa-compressor",249:"nr-spa-recorder",478:"nr-spa"}[e]+"-1.274.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.274.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={478:"sha512-1vUqEfJPB8Pihje9mv5CfYgkitO1FWcS+UQb84DbXqP8oYctRv4/lzl/MzNLPlRhcY1WVDBGL20I8vm6s2VV7g==",249:"sha512-Y/BeZAh6VSTmUtUNmS5XdyKxL92s30Fyyj8xVW76HSPxcKItL4+x2+kGMZc8pMJnUpZDz1L4eftZQAJh3D8NnA==",212:"sha512-Gn2tQ3qog5Yhrx/gRutkSTYPp+7nkKFt4/mIXg99LxcNpMDAYJZDBYmAACdoHNM86+iq1F3cBcQotFNzjIX8bw=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={38:0,788:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.274.0.PROD"]=self["webpackChunk:NRBA-1.274.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(944),t=i(6344),r=i(9566);class n{agentIdentifier;constructor(e=(0,r.LA)(16)){this.agentIdentifier=e}#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}addPageAction(e,t){return this.#e("addPageAction",e,t)}setPageViewName(e,t){return this.#e("setPageViewName",e,t)}setCustomAttribute(e,t,r){return this.#e("setCustomAttribute",e,t,r)}noticeError(e,t){return this.#e("noticeError",e,t)}setUserId(e){return this.#e("setUserId",e)}setApplicationVersion(e){return this.#e("setApplicationVersion",e)}setErrorHandler(e){return this.#e("setErrorHandler",e)}addRelease(e,t){return this.#e("addRelease",e,t)}log(e,t){return this.#e("log",e,t)}}class o extends n{#e(t,...r){if("function"==typeof this.api?.[t])return this.api[t](...r);(0,e.R)(35,t)}start(){return this.#e("start")}finished(e){return this.#e("finished",e)}recordReplay(){return this.#e(t.G4.RECORD)}pauseReplay(){return this.#e(t.G4.PAUSE)}addToTrace(e){return this.#e("addToTrace",e)}setCurrentRouteName(e){return this.#e("setCurrentRouteName",e)}interaction(){return this.#e("interaction")}wrapLogger(e,t,r){return this.#e("wrapLogger",e,t,r)}}var a=i(860),s=i(9417);const c=Object.values(a.K7);function u(e){const t={};return c.forEach((r=>{t[r]=function(e,t){return!0===(0,s.gD)(t,"".concat(e,".enabled"))}(r,e)})),t}var d=i(425);var l=i(1687),f=i(4234),h=i(5289),p=i(6154),g=i(5270),m=i(7767),v=i(6389);class b extends f.W{constructor(e,t,r=!0){super(e.agentIdentifier,t),this.auto=r,this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,!1===e.init[this.featureName].autoStart&&(this.auto=!1),this.auto?(0,l.Ak)(e.agentIdentifier,t):this.ee.on("manual-start-all",(0,v.J)((()=>{(0,l.Ak)(e.agentIdentifier,this.featureName),this.auto=!0,this.importAggregator(e)})))}importAggregator(t,r={}){if(this.featAggregate||!this.auto)return;let n;this.onAggregateImported=new Promise((e=>{n=e}));const o=async()=>{let o;try{if((0,m.V)(this.agentIdentifier)){const{setupAgentSession:e}=await i.e(478).then(i.bind(i,6526));o=e(t)}}catch(t){(0,e.R)(20,t),this.ee.emit("internal-error",[t]),this.featureName===a.K7.sessionReplay&&this.abortHandler?.()}try{if(t.sharedAggregator)await t.sharedAggregator;else{t.sharedAggregator=i.e(478).then(i.bind(i,9337));const{EventAggregator:e}=await t.sharedAggregator;t.sharedAggregator=new e}if(!this.#t(this.featureName,o))return(0,l.Ze)(this.agentIdentifier,this.featureName),void n(!1);const{lazyFeatureLoader:e}=await i.e(478).then(i.bind(i,6103)),{Aggregate:a}=await e(this.featureName,"aggregate");this.featAggregate=new a(t,r),n(!0)}catch(t){(0,e.R)(34,t),this.abortHandler?.(),(0,l.Ze)(this.agentIdentifier,this.featureName,!0),n(!1),this.ee&&this.ee.abort()}};p.RI?(0,h.GG)((()=>o()),!0):o()}#t(e,t){switch(e){case a.K7.sessionReplay:return(0,g.SR)(this.agentIdentifier)&&!!t;case a.K7.sessionTrace:return!!t;default:return!0}}}var y=i(6630);class w extends b{static featureName=y.T;constructor(e,t=!0){super(e,y.T,t),this.importAggregator(e)}}var R=i(384);var x=i(9908),T=i(2843),A=i(3878),E=i(782),S=i(1863);class N extends b{static featureName=E.T;constructor(e,t=!0){super(e,E.T,t),p.RI&&((0,T.u)((()=>(0,x.p)("docHidden",[(0,S.t)()],void 0,E.T,this.ee)),!0),(0,A.sp)("pagehide",(()=>(0,x.p)("winPagehide",[(0,S.t)()],void 0,E.T,this.ee))),this.importAggregator(e))}}var O=i(3969);class _ extends b{static featureName=O.TZ;constructor(e,t=!0){super(e,O.TZ,t),this.importAggregator(e)}}var I=i(6774),j=i(3304);class P{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,j.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function C(e){return H(e)?e:new P(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function k(e){const t="Unhandled Promise Rejection";if(!e?.reason)return;if(H(e.reason))try{return e.reason.message=t+": "+e.reason.message,C(e.reason)}catch(t){return C(e.reason)}const r=C(e.reason);return r.message=t+": "+r?.message,r}function L(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new P(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return H(e.error)?e.error:C(e)}function H(e){return e instanceof Error&&!!e.stack}class D extends b{static featureName=I.T;#r=!1;constructor(e,r=!0){super(e,I.T,r);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",(e=>{this.abortHandler&&(0,x.p)("ierr",[C(e),(0,S.t)(),!0,{},this.#r],void 0,this.featureName,this.ee)})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.#r=e})),p.gm.addEventListener("unhandledrejection",(e=>{this.abortHandler&&(0,x.p)("err",[k(e),(0,S.t)(),!1,{unhandledPromiseRejection:1},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),p.gm.addEventListener("error",(e=>{this.abortHandler&&(0,x.p)("err",[L(e),(0,S.t)(),!1,{},this.#r],void 0,this.featureName,this.ee)}),(0,A.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var M=i(8990);let K=1;const U="nr@id";function V(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===p.gm?0:(0,M.I)(e,U,(function(){return K++}))}function G(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,j.A)(e).length}catch(e){return}}}var F=i(8139),B=i(7836),W=i(3434);const z={},q=["open","send"];function Z(t){var r=t||B.ee;const n=function(e){return(e||B.ee).get("xhr")}(r);if(z[n.debugId]++)return n;z[n.debugId]=1,(0,F.u)(r);var i=(0,W.YM)(n),o=p.gm.XMLHttpRequest,a=p.gm.MutationObserver,s=p.gm.Promise,c=p.gm.setInterval,u="readystatechange",d=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],l=[],f=p.gm.XMLHttpRequest=function(t){const r=new o(t),a=n.context(r);try{n.emit("new-xhr",[r],a),r.addEventListener(u,(s=a,function(){var e=this;e.readyState>3&&!s.resolved&&(s.resolved=!0,n.emit("xhr-resolved",[],e)),i.inPlace(e,d,"fn-",y)}),(0,A.jT)(!1))}catch(t){(0,e.R)(15,t);try{n.emit("internal-error",[t])}catch(e){}}var s;return r};function h(e,t){i.inPlace(t,["onreadystatechange"],"fn-",y)}if(function(e,t){for(var r in e)t[r]=e[r]}(o,f),f.prototype=o.prototype,i.inPlace(f.prototype,q,"-xhr-",y),n.on("send-xhr-start",(function(e,t){h(e,t),function(e){l.push(e),a&&(g?g.then(b):c?c(b):(m=-m,v.data=m))}(t)})),n.on("open-xhr-start",h),a){var g=s&&s.resolve();if(!c&&!s){var m=1,v=document.createTextNode(m);new a(b).observe(v,{characterData:!0})}}else r.on("fn-end",(function(e){e[0]&&e[0].type===u||b()}));function b(){for(var e=0;e<l.length;e++)h(0,l[e]);l.length&&(l=[])}function y(e,t){return t}return n}var Y="fetch-",X=Y+"body-",J=["arrayBuffer","blob","json","text","formData"],Q=p.gm.Request,ee=p.gm.Response,te="prototype";const re={};function ne(e){const t=function(e){return(e||B.ee).get("fetch")}(e);if(!(Q&&ee&&p.gm.fetch))return t;if(re[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[B.P]&&o[B.P].dt&&(e=o[B.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return re[t.debugId]=1,J.forEach((e=>{r(Q[te],e,X),r(ee[te],e,X)})),r(p.gm,"fetch",Y),t.on(Y+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(Y+"done",[null,r],n)}else t.emit(Y+"done",[e],n)})),t}var ie=i(7485),oe=i(5603);class ae{constructor(e){this.agentIdentifier=e}generateTracePayload(e){if(!this.shouldGenerateTrace(e))return null;var t=(0,oe.o)(this.agentIdentifier);if(!t)return null;var n=(t.accountID||"").toString()||null,i=(t.agentID||"").toString()||null,o=(t.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,r.ZF)(),s=(0,r.el)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(e.sameOrigin||this.isAllowedOrigin(e)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(e.sameOrigin&&!this.excludeNewrelicHeader()||!e.sameOrigin&&this.isAllowedOrigin(e)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof p.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,j.A)(a))}shouldGenerateTrace(e){return this.isDtEnabled()&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1,r={};if((0,s.gD)(this.agentIdentifier,"distributed_tracing")&&(r=(0,s.D0)(this.agentIdentifier).distributed_tracing),e.sameOrigin)t=!0;else if(r.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,ie.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}isDtEnabled(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.enabled}excludeNewrelicHeader(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=(0,s.gD)(this.agentIdentifier,"distributed_tracing");return!!e&&!!e.cors_use_tracecontext_headers}}var se=i(9300),ce=i(7295),ue=["load","error","abort","timeout"],de=ue.length,le=(0,R.dV)().o.REQ,fe=(0,R.dV)().o.XHR;class he extends b{static featureName=se.T;constructor(e,t=!0){super(e,se.T,t),this.dt=new ae(e.agentIdentifier),this.handler=(e,t,r,n)=>(0,x.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};p.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},n={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};pe(r,t.name),this.handler("xhr",[r,n,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,a.K7.ajax)}}))}catch(e){}ne(this.ee),Z(this.ee),function(e,t,r,n){function i(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=R,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){T(t,e)}),(0,A.jT)(!1)),p.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,A.jT)(!1))}function o(e){this.params={method:e[0]},pe(this,e[1]),this.metrics={}}function s(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var i=n.generateTracePayload(this.parsedOrigin);if(i){var o=!1;i.newrelicHeader&&(r.setRequestHeader("newrelic",i.newrelicHeader),o=!0),i.traceContextParentHeader&&(r.setRequestHeader("traceparent",i.traceContextParentHeader),i.traceContextStateHeader&&r.setRequestHeader("tracestate",i.traceContextStateHeader),o=!0),o&&(this.dt=i)}}function c(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=G(i);a&&(n.txSize=a)}this.startTime=(0,S.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<de;s++)r.addEventListener(ue[s],this.listener,(0,A.jT)(!1))}function u(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function d(e,t){var r=""+V(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function l(e,t){var r=""+V(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function f(){this.endTime=(0,S.t)()}function h(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function g(e,r){r instanceof fe&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function m(e,t,r){t instanceof fe&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,S.t)()))}function v(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,S.t)()-this.xhrCbStart,this.onload,r],r)}function b(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&p.RI&&(t=""+p.gm.location.href):e[0]&&e[0].url?t=e[0].url:p.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,ie.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var i=n.generateTracePayload(this.parsedOrigin);if(i&&(i.newrelicHeader||i.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,i)&&(this.dt=i);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,i)&&(this.dt=i),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function y(e,t){this.params={},this.metrics={},this.startTime=(0,S.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof le?r=i.url:p.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),pe(this,r);var o=(""+(i&&i instanceof le&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=G(n.body)||0}function w(e,t){if(this.endTime=(0,S.t)(),this.params||(this.params={}),(0,ce.iW)(this.params))return;let n;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(n=+this.rxSize);const i={txSize:this.txSize,rxSize:n,duration:(0,S.t)()-this.startTime};r("xhr",[this.params,i,this.startTime,this.endTime,"fetch"],this,a.K7.ajax)}function R(e){const t=this.params,n=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<de;t++)e.removeEventListener(ue[t],this.listener,!1);t.aborted||(0,ce.iW)(t)||(n.duration=(0,S.t)()-this.startTime,this.loadCazptureCalled||4!==e.readyState?null==t.status&&(t.status=0):T(this,e),n.cbTime=this.cbTime,r("xhr",[t,n,this.startTime,this.endTime,"xhr"],this,a.K7.ajax))}}function T(e,r){e.params.status=r.status;var n=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?G(e.response):"text"===r||""===r||void 0===r?G(e.responseText):void 0}(r,e.lastSize);if(n&&(e.metrics.rxSize=n),e.sameOrigin){var i=r.getResponseHeader("X-NewRelic-App-Data");i&&((0,x.p)(O.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,a.K7.metrics,t),e.params.cat=i.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",i),t.on("open-xhr-start",o),t.on("open-xhr-end",s),t.on("send-xhr-start",c),t.on("xhr-cb-time",u),t.on("xhr-load-added",d),t.on("xhr-load-removed",l),t.on("xhr-resolved",f),t.on("addEventListener-end",h),t.on("removeEventListener-end",g),t.on("fn-end",v),t.on("fetch-before-start",b),t.on("fetch-start",y),t.on("fn-start",m),t.on("fetch-done",w)}(e,this.ee,this.handler,this.dt),this.importAggregator(e)}}function pe(e,t){var r=(0,ie.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const ge={},me=["pushState","replaceState"];function ve(e){const t=function(e){return(e||B.ee).get("history")}(e);return!p.RI||ge[t.debugId]++||(ge[t.debugId]=1,(0,W.YM)(t).inPlace(window.history,me,"-")),t}var be=i(3738);const{He:ye,bD:we,d3:Re,Kp:xe,TZ:Te,Lc:Ae,uP:Ee,Rz:Se}=be;class Ne extends b{static featureName=Te;constructor(e,t=!0){super(e,Te,t);if(!(0,m.V)(this.agentIdentifier))return void this.deregisterDrain();const r=this.ee;let n;ve(r),this.eventsEE=(0,F.u)(r),this.eventsEE.on(Ee,(function(e,t){this.bstStart=(0,S.t)()})),this.eventsEE.on(Ae,(function(e,t){(0,x.p)("bst",[e[0],t,this.bstStart,(0,S.t)()],void 0,a.K7.sessionTrace,r)})),r.on(Se+Re,(function(e){this.time=(0,S.t)(),this.startPath=location.pathname+location.hash})),r.on(Se+xe,(function(e){(0,x.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,a.K7.sessionTrace,r)}));try{n=new PerformanceObserver((e=>{const t=e.getEntries();(0,x.p)(ye,[t],void 0,a.K7.sessionTrace,r)})),n.observe({type:we,buffered:!0})}catch(e){}this.importAggregator(e,{resourceObserver:n})}}var Oe=i(2614);class _e extends b{static featureName=t.TZ;#i;#o;constructor(e,r=!0){let n;super(e,t.TZ,r),this.replayRunning=!1,this.#o=e;try{n=JSON.parse(localStorage.getItem("".concat(Oe.H3,"_").concat(Oe.uh)))}catch(e){}(0,g.SR)(e.agentIdentifier)&&this.ee.on(t.G4.RECORD,(()=>this.#a())),this.#s(n)?(this.#i=n?.sessionReplayMode,this.#c()):this.importAggregator(e),this.ee.on("err",(e=>{this.replayRunning&&(this.errorNoticed=!0,(0,x.p)(t.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))})),this.ee.on(t.G4.REPLAY_RUNNING,(e=>{this.replayRunning=e}))}#s(e){return e&&(e.sessionReplayMode===Oe.g.FULL||e.sessionReplayMode===Oe.g.ERROR)||(0,g.Aw)(this.agentIdentifier)}#u=!1;async#c(e){if(!this.#u){this.#u=!0;try{const{Recorder:t}=await Promise.all([i.e(478),i.e(249)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#i,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){}this.importAggregator(this.#o,{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#a(){this.featAggregate?this.featAggregate.mode!==Oe.g.FULL&&this.featAggregate.initializeRecording(Oe.g.FULL,!0):(this.#i=Oe.g.FULL,this.#c(t.Qb.API),this.recorder&&this.recorder.parent.mode!==Oe.g.FULL&&(this.recorder.parent.mode=Oe.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ie=i(3962);class je extends b{static featureName=Ie.TZ;constructor(e,t=!0){if(super(e,Ie.TZ,t),!p.RI||!(0,R.dV)().o.MO)return;const r=ve(this.ee);Ie.tC.forEach((e=>{(0,A.sp)(e,(e=>{a(e)}),!0)}));const n=()=>(0,x.p)("newURL",[(0,S.t)(),""+window.location],void 0,this.featureName,this.ee);r.on("pushState-end",n),r.on("replaceState-end",n);try{this.removeOnAbort=new AbortController}catch(e){}(0,A.sp)("popstate",(e=>(0,x.p)("newURL",[e.timeStamp,""+window.location],void 0,this.featureName,this.ee)),!0,this.removeOnAbort?.signal);let i=!1;const o=new((0,R.dV)().o.MO)(((e,t)=>{i||(i=!0,requestAnimationFrame((()=>{(0,x.p)("newDom",[(0,S.t)()],void 0,this.featureName,this.ee),i=!1})))})),a=(0,v.s)((e=>{(0,x.p)("newUIEvent",[e],void 0,this.featureName,this.ee),o.observe(document.body,{attributes:!0,childList:!0,subtree:!0,characterData:!0})}),100,{leading:!0});this.abortHandler=function(){this.removeOnAbort?.abort(),o.disconnect(),this.abortHandler=void 0},this.importAggregator(e,{domObserver:o})}}var Pe=i(7378);const Ce={},ke=["appendChild","insertBefore","replaceChild"];function Le(e){const t=function(e){return(e||B.ee).get("jsonp")}(e);if(!p.RI||Ce[t.debugId])return t;Ce[t.debugId]=!0;var r=(0,W.YM)(t),n=/[?&](?:callback|cb)=([^&#]+)/,i=/(.*)\.([^.]+)/,o=/^(\w+)(\.|$)(.*)$/;function a(e,t){if(!e)return t;const r=e.match(o),n=r[1];return a(r[3],t[n])}return r.inPlace(Node.prototype,ke,"dom-"),t.on("dom-start",(function(e){!function(e){if(!e||"string"!=typeof e.nodeName||"script"!==e.nodeName.toLowerCase())return;if("function"!=typeof e.addEventListener)return;var o=(s=e.src,c=s.match(n),c?c[1]:null);var s,c;if(!o)return;var u=function(e){var t=e.match(i);if(t&&t.length>=3)return{key:t[2],parent:a(t[1],window)};return{key:e,parent:window}}(o);if("function"!=typeof u.parent[u.key])return;var d={};function l(){t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}function f(){t.emit("jsonp-error",[],d),t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,A.jT)(!1)),e.removeEventListener("error",f,(0,A.jT)(!1))}r.inPlace(u.parent,[u.key],"cb-",d),e.addEventListener("load",l,(0,A.jT)(!1)),e.addEventListener("error",f,(0,A.jT)(!1)),t.emit("new-jsonp",[e.src],d)}(e[0])})),t}const He={};function De(e){const t=function(e){return(e||B.ee).get("promise")}(e);if(He[t.debugId])return t;He[t.debugId]=!0;var r=t.context,n=(0,W.YM)(t),i=p.gm.Promise;return i&&function(){function e(r){var o=t.context(),a=n(r,"executor-",o,null,!1);const s=Reflect.construct(i,[a],e);return t.context(s).getCtx=function(){return o},s}p.gm.Promise=e,Object.defineProperty(e,"name",{value:"Promise"}),e.toString=function(){return i.toString()},Object.setPrototypeOf(e,i),["all","race"].forEach((function(r){const n=i[r];e[r]=function(e){let i=!1;[...e||[]].forEach((e=>{this.resolve(e).then(a("all"===r),a(!1))}));const o=n.apply(this,arguments);return o;function a(e){return function(){t.emit("propagate",[null,!i],o,!1,!1),i=i||!e}}}})),["resolve","reject"].forEach((function(r){const n=i[r];e[r]=function(e){const r=n.apply(this,arguments);return e!==r&&t.emit("propagate",[e,!0],r,!1,!1),r}})),e.prototype=i.prototype;const o=i.prototype.then;i.prototype.then=function(...e){var i=this,a=r(i);a.promise=i,e[0]=n(e[0],"cb-",a,null,!1),e[1]=n(e[1],"cb-",a,null,!1);const s=o.apply(this,e);return a.nextPromise=s,t.emit("propagate",[i,!0],s,!1,!1),s},i.prototype.then[W.Jt]=o,t.on("executor-start",(function(e){e[0]=n(e[0],"resolve-",this,null,!1),e[1]=n(e[1],"resolve-",this,null,!1)})),t.on("executor-err",(function(e,t,r){e[1](r)})),t.on("cb-end",(function(e,r,n){t.emit("propagate",[n,!0],this.nextPromise,!1,!1)})),t.on("propagate",(function(e,r,n){this.getCtx&&!r||(this.getCtx=function(){if(e instanceof Promise)var r=t.context(e);return r&&r.getCtx?r.getCtx():this})}))}(),t}const Me={},Ke="setTimeout",Ue="setInterval",Ve="clearTimeout",Ge="-start",Fe=[Ke,"setImmediate",Ue,Ve,"clearImmediate"];function Be(e){const t=function(e){return(e||B.ee).get("timer")}(e);if(Me[t.debugId]++)return t;Me[t.debugId]=1;var r=(0,W.YM)(t);return r.inPlace(p.gm,Fe.slice(0,2),Ke+"-"),r.inPlace(p.gm,Fe.slice(2,3),Ue+"-"),r.inPlace(p.gm,Fe.slice(3),Ve+"-"),t.on(Ue+Ge,(function(e,t,n){e[0]=r(e[0],"fn-",null,n)})),t.on(Ke+Ge,(function(e,t,n){this.method=n,this.timerDuration=isNaN(e[1])?0:+e[1],e[0]=r(e[0],"fn-",this,n)})),t}const We={};function ze(e){const t=function(e){return(e||B.ee).get("mutation")}(e);if(!p.RI||We[t.debugId])return t;We[t.debugId]=!0;var r=(0,W.YM)(t),n=p.gm.MutationObserver;return n&&(window.MutationObserver=function(e){return this instanceof n?new n(r(e,"fn-")):n.apply(this,arguments)},MutationObserver.prototype=n.prototype),t}const{TZ:qe,d3:Ze,Kp:Ye,$p:Xe,wW:Je,e5:Qe,tH:$e,uP:et,rw:tt,Lc:rt}=Pe;class nt extends b{static featureName=qe;constructor(e,t=!0){if(super(e,qe,t),!p.RI)return;try{this.removeOnAbort=new AbortController}catch(e){}let r,n=0;const i=this.ee.get("tracer"),o=Le(this.ee),a=De(this.ee),s=Be(this.ee),c=Z(this.ee),u=this.ee.get("events"),d=ne(this.ee),l=ve(this.ee),f=ze(this.ee);function h(e,t){l.emit("newURL",[""+window.location,t])}function g(){n++,r=window.location.hash,this[et]=(0,S.t)()}function m(){n--,window.location.hash!==r&&h(0,!0);var e=(0,S.t)();this[Qe]=~~this[Qe]+e-this[et],this[rt]=e}function v(e,t){e.on(t,(function(){this[t]=(0,S.t)()}))}this.ee.on(et,g),a.on(tt,g),o.on(tt,g),this.ee.on(rt,m),a.on(Je,m),o.on(Je,m),this.ee.on("fn-err",((...t)=>{t[2]?.__newrelic?.[e.agentIdentifier]||(0,x.p)("function-err",[...t],void 0,this.featureName,this.ee)})),this.ee.buffer([et,rt,"xhr-resolved"],this.featureName),u.buffer([et],this.featureName),s.buffer(["setTimeout"+Ye,"clearTimeout"+Ze,et],this.featureName),c.buffer([et,"new-xhr","send-xhr"+Ze],this.featureName),d.buffer([$e+Ze,$e+"-done",$e+Xe+Ze,$e+Xe+Ye],this.featureName),l.buffer(["newURL"],this.featureName),f.buffer([et],this.featureName),a.buffer(["propagate",tt,Je,"executor-err","resolve"+Ze],this.featureName),i.buffer([et,"no-"+et],this.featureName),o.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"],this.featureName),v(d,$e+Ze),v(d,$e+"-done"),v(o,"new-jsonp"),v(o,"jsonp-end"),v(o,"cb-start"),l.on("pushState-end",h),l.on("replaceState-end",h),window.addEventListener("hashchange",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("load",h,(0,A.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("popstate",(function(){h(0,n>1)}),(0,A.jT)(!0,this.removeOnAbort?.signal)),this.abortHandler=this.#n,this.importAggregator(e)}#n(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var it=i(3333);class ot extends b{static featureName=it.TZ;constructor(e,t=!0){super(e,it.TZ,t);const r=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled];p.RI&&e.init.user_actions.enabled&&(it.Zp.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),it.qN.forEach((e=>(0,A.sp)(e,(e=>(0,x.p)("ua",[e],void 0,this.featureName,this.ee)))))),r.some((e=>e))?this.importAggregator(e):this.deregisterDrain()}}var at=i(993),st=i(3785);class ct extends b{static featureName=at.TZ;constructor(e,t=!0){super(e,at.TZ,t);const r=this.ee;this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,st.R)(r,e,n,t)})),this.importAggregator(e)}}new class extends o{constructor(t,r){super(r),p.gm?(this.features={},(0,R.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(t.features||[]),this.desiredFeatures.add(w),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===a.K7.softNav)),(0,d.j)(this,t,t.loaderType||"agent"),this.run()):(0,e.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}run(){try{const t=u(this.agentIdentifier),r=[...this.desiredFeatures];r.sort(((e,t)=>a.P3[e.featureName]-a.P3[t.featureName])),r.forEach((r=>{if(!t[r.featureName]&&r.featureName!==a.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&r.featureName===a.K7.spa)return;if(!this.runSoftNavOverSpa&&r.featureName===a.K7.softNav)return;const n=function(e){switch(e){case a.K7.ajax:return[a.K7.jserrors];case a.K7.sessionTrace:return[a.K7.ajax,a.K7.pageViewEvent];case a.K7.sessionReplay:return[a.K7.sessionTrace];case a.K7.pageViewTiming:return[a.K7.pageViewEvent];default:return[]}}(r.featureName).filter((e=>!(e in this.features)));n.length>0&&(0,e.R)(36,{targetFeature:r.featureName,missingDependencies:n}),this.features[r.featureName]=new r(this)}))}catch(t){(0,e.R)(22,t);for(const e in this.features)this.features[e].abortHandler?.();const r=(0,R.Zm)();delete r.initializedAgents[this.agentIdentifier]?.api,delete r.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return r.ee.get(this.agentIdentifier).abort(),!1}}}({features:[he,w,N,Ne,_e,_,D,ot,ct,je,nt],loaderType:"spa"})})()})();</script> <noscript><style>form.antibot * :not(.antibot-message) { display: none !important; }</style> </noscript><link rel="canonical" href="https://www.alnylam.com/404-not-found" /> <meta name="Generator" content="Drupal 9 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <link rel="icon" href="/sites/default/files/favicon_0.png" type="image/png" /> <link rel="alternate" hreflang="en" href="https://www.alnylam.com/404-not-found" /> <title>404 not found | Alnylam</title> <link rel="stylesheet" media="all" href="/libraries/slick/slick/slick.css?snb4hv" /> <link rel="stylesheet" media="all" href="/libraries/superfish/css/superfish.css?snb4hv" /> <link rel="stylesheet" media="all" href="/modules/composer/slick/css/layout/slick.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/align.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/fieldgroup.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/container-inline.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/clearfix.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/details.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/hidden.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/item-list.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/js.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/nowrap.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/position-container.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/progress.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/reset-appearance.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/resize.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/sticky-header.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-counter.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-counters.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/system-status-report-general-info.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/tablesort.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/core/modules/system/css/components/tree-child.module.css?snb4hv" /> <link rel="stylesheet" media="all" href="/modules/composer/blazy/css/blazy.css?snb4hv" /> <link rel="stylesheet" media="all" href="/modules/composer/blazy/css/components/blazy.loading.css?snb4hv" /> <link rel="stylesheet" media="all" href="/libraries/slick/slick/slick-theme.css?snb4hv" /> <link rel="stylesheet" media="all" href="/modules/composer/colorbox/styles/default/colorbox_style.css?snb4hv" /> <link rel="stylesheet" media="all" href="https://use.fontawesome.com/releases/v5.13.1/css/all.css" /> <link rel="stylesheet" media="all" href="https://use.fontawesome.com/releases/v5.13.1/css/v4-shims.css" /> <link rel="stylesheet" media="all" href="/modules/composer/paragraphs/css/paragraphs.unpublished.css?snb4hv" /> <link rel="stylesheet" media="all" href="/modules/custom/alnylam_search/css/alnylam_search.css?snb4hv" /> <link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/css/bootstrap.css" /> <link rel="stylesheet" media="all" href="https://cdn.jsdelivr.net/npm/@unicorn-fail/drupal-bootstrap-styles@0.0.2/dist/3.4.0/8.x-3.x/drupal-bootstrap.css" integrity="sha512-j4mdyNbQqqp+6Q/HtootpbGoc2ZX0C/ktbXnauPFEz7A457PB6le79qasOBVcrSrOBtGAm0aVU2SOKFzBl6RhA==" crossorigin="anonymous" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/style.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/themes.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/header.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/footer.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/modal.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/banner.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/ipad.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/mobile.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/mobile-user.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/trials.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/signup-update.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/signup-us-residents.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/full-html.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/five_tabs_section.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/circle-slider.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/accordian-two-col.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/multi_columns_section.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/banner-overlay-html-content.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/heading-video-description.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/two-column-left-content-box.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/callout-h1-cta.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/full-width-video.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/image-title-description.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/center-cards.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/contact-us-4-column-card.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/video-pou-up.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/3-column-card.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/video-with-content.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/service-section.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/cards-with-icon-and-title.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/bio-card-section.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/diversity-equity-inclusion.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/patient-philosophy.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/infographic.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/body-points.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/title_with_description_and_cards.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/carousel.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/job-search.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/box-slide.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/full-text-three-cards.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/four-card-images.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/image-with-quote.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/de_i_cards.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/slick-overlay.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/colored-four-cards.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/mobile-medical-professional.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/mobile-patients.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/mobile-signup-update.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/clp.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/clp-header.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/clp-slideshow.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/clp-footer.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/clp-modal.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/clp-mobile.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/media-kit.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/mobile-media-kit.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/user1.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/user2.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/custom-style-1.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/custom-style-2.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/utility.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/callout-corporate-report.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/paragraphs/as_nav_for_content_image.css?snb4hv" /> <link rel="stylesheet" media="all" href="/themes/custom/alnylam/css/user3.css?snb4hv" /> <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.5.1/jquery.min.js"></script> <script src="https://cdn.jsdelivr.net/npm/bootstrap@5.1.3/dist/js/bootstrap.min.js" integrity="sha384-QJHtvGhmr9XOIpI6YVutG+2QOK9T+ZnN4kzFN1RtK3zEFEIsxhlmWl5/YESvpZ13" crossorigin="anonymous"></script> </head> <body class="page-node-56 path-innerpage not-front path-page-not-found page-node-type-page no-sidebars has-glyphicons" class="page-node-56 path-innerpage not-front path-page-not-found page-node-type-page no-sidebars has-glyphicons"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <header> <div class="header-wrapper"> <div id="whole-mobile-header" class="container-fluid"> <div class="mobile-block"> <div class="mobile-header-menu"> <div class="region region-mobile-menu"> <section id="block-mobilemainnavigation" class="block block-superfish block-superfishmobile-main-menu clearfix"> <ul id="superfish-mobile-main-menu" class="menu sf-menu sf-mobile-main-menu sf-horizontal sf-style-none"> <li id="mobile-main-menu-menu-link-content145d8319-203d-4f69-9e9d-f65fa2e47a85" class="sf-depth-1 menuparent"><span class="our-company sf-depth-1 menuparent nolink">Our Company</span><ul><li id="mobile-main-menu-menu-link-content1a521d26-dfad-413c-8b97-cb55d153ab27" class="sf-depth-2 sf-no-children"><a href="/about-alnylam" class="our-company sf-depth-2">About Alnylam</a></li><li id="mobile-main-menu-menu-link-content3ecf5446-204f-4d4d-82ab-46caa3a2d0ea" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/alnylam-leadership" class="our-company sf-depth-2">Leadership</a></li><li id="mobile-main-menu-menu-link-content7d9ef835-8a46-4d4f-a857-dd70f686c3a7" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/diversity-inclusion" class="our-company sf-depth-2">Diversity, Equity & Inclusion</a></li><li id="mobile-main-menu-menu-link-content9063c2c0-d2ed-453c-a120-aef372aed146" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/patient-access-philosophy" class="our-company sf-depth-2">Patient Access Philosophy</a></li><li id="mobile-main-menu-menu-link-content38c28e6b-b2e0-4683-9ea8-b5bba445a9a1" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/corporate-responsibility" class="our-company sf-depth-2">Corporate Responsibility</a></li><li id="mobile-main-menu-menu-link-content6ad6f37d-26a7-402a-9136-60976da07ff3" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/transparency" class="our-company bullet-point sf-depth-2"> Transparency</a></li><li id="mobile-main-menu-menu-link-contentee2556f4-ca31-4621-8f1e-9efcd92847e1" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/grants-and-giving" class="our-company sf-depth-2">Grants & Giving</a></li><li id="mobile-main-menu-menu-link-contentf00cf2ce-d91b-461e-b59e-6c8b37c54bef" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/grants-and-giving/advocacy-for-impact-grants" class="our-company bullet-point sf-depth-2">Advocacy for Impact Grants</a></li><li id="mobile-main-menu-menu-link-contenta635d30a-0b18-42b3-8b46-bab6b3bd0f16" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/investigator-initiated-studies" class="our-company sf-depth-2">Investigator Initiated Studies (IIS)</a></li></ul></li><li id="mobile-main-menu-menu-link-contentdb336fa7-b0e7-4022-87e2-84094cf624c4" class="sf-depth-1 menuparent"><span class="our-science sf-depth-1 menuparent nolink">Our Science</span><ul><li id="mobile-main-menu-menu-link-contentb7cb3399-2c54-40a5-9176-e8508a72790d" class="sf-depth-2 sf-no-children"><a href="/our-science/the-science-of-rnai" class="our-science sf-depth-2">The Science of RNAi</a></li><li id="mobile-main-menu-menu-link-content2bb42bdf-0a8b-4bbe-8360-f23e436b781c" class="sf-depth-2 sf-no-children"><a href="/our-science/sirna-delivery-platforms" class="our-science sf-depth-2">Delivery Platforms</a></li><li id="mobile-main-menu-menu-link-content864a206c-7443-43e2-a1fd-dc97104f13ee" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline" class="our-science sf-depth-2">Therapeutic Areas</a></li><li id="mobile-main-menu-menu-link-content10eafc65-9679-480e-82cf-790a198bff23" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline" class="our-science bullet-point sf-depth-2">Pipeline</a></li><li id="mobile-main-menu-menu-link-contentb3ebed05-afe1-4d4e-b2b9-2068791c8d6e" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline/clinical-trials" class="our-science bullet-point sf-depth-2">Clinical Trials</a></li><li id="mobile-main-menu-menu-link-content4a1a58d6-b693-42eb-b46e-d2ac0fb1a71c" class="sf-depth-2 sf-no-children"><a href="/our-science/alnylam-scientific-advisory-board" class="our-science sf-depth-2">Scientific Advisory Board</a></li><li id="mobile-main-menu-menu-link-content92e775d9-ed7a-46e8-86c4-140b123ac958" class="sf-depth-2 sf-no-children"><a href="/our-science/intellectual-property" class="our-science sf-depth-2">Intellectual Property</a></li><li id="mobile-main-menu-menu-link-content98520e22-8c64-4286-b38c-ab67cafad835" class="sf-depth-2 sf-no-children"><a href="/our-science/capella-rnai-innovation" class="our-science sf-depth-2">Capella (Scientific Presentations)</a></li></ul></li><li id="mobile-main-menu-menu-link-content0e31c1a0-c1c2-4b4f-9c3e-5239ef378c62" class="sf-depth-1 menuparent"><span class="our-products sf-depth-1 menuparent nolink">Our Products</span><ul><li id="mobile-main-menu-menu-link-content4e5215d6-d670-4423-9505-cadab42aed55" class="sf-depth-2 sf-no-children"><a href="/our-products" class="our-products sf-depth-2">Product Listing</a></li></ul></li><li id="mobile-main-menu-menu-link-content367edda2-bdd9-483e-97fd-05c2a8eefdad" class="sf-depth-1 menuparent"><span class="our-news sf-depth-1 menuparent nolink">Our News</span><ul><li id="mobile-main-menu-menu-link-contentc7463cca-1961-4472-a53f-97592642e508" class="sf-depth-2 sf-no-children"><a href="https://news.alnylam.com/" class="our-news sf-depth-2 sf-external">Newsroom</a></li><li id="mobile-main-menu-menu-link-content44dc4173-805a-487f-af66-df33d15ac59e" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/press-releases" class="our-news sf-depth-2 sf-external">Press Releases</a></li><li id="mobile-main-menu-menu-link-content17141470-35b5-4b48-b5fc-1de4821ff87c" class="sf-depth-2 sf-no-children"><a href="https://capella.alnylam.com/our-science/capella-rnai-innovation/" class="our-news sf-depth-2 sf-external">Capella (Scientific Presentations)</a></li><li id="mobile-main-menu-menu-link-content9e09cf1f-5dd1-4571-be9c-4411b7f06bb4" class="sf-depth-2 sf-no-children"><a href="/media-kit" class="our-news sf-depth-2">Media Kit</a></li></ul></li><li id="mobile-main-menu-menu-link-content2fd397d7-c8cd-4255-977e-83d7914cc430" class="sf-depth-1 menuparent"><span class="investors sf-depth-1 menuparent nolink">Investors</span><ul><li id="mobile-main-menu-menu-link-content6bee62a8-b6d6-4e27-a7fa-aa9a6e3656d5" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/" class="sf-depth-2 sf-external">For Investors</a></li><li id="mobile-main-menu-menu-link-content66876014-8534-4885-b003-e568f278d94a" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/alny-stock-information" class="sf-depth-2 sf-external">Stock Information</a></li><li id="mobile-main-menu-menu-link-content6ffc2aea-051a-497b-bffe-f7a1e1bfbcf6" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/investor-toolkit" class="sf-depth-2 sf-external">Investors Toolkit</a></li><li id="mobile-main-menu-menu-link-content011e25b7-dcaa-4ff3-abf5-940bf5675011" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/events" class="sf-depth-2 sf-external">Events & Presentations</a></li><li id="mobile-main-menu-menu-link-content944b0062-319c-4ba2-b99b-8d92a0b01ce8" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/financial-information" class="sf-depth-2 sf-external">Financial Information</a></li><li id="mobile-main-menu-menu-link-content898eeca9-13ee-4fa4-9256-9ecc67143686" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/financial-information?sec=#sec_filings" class="sf-depth-2 sf-external">SEC Filings</a></li><li id="mobile-main-menu-menu-link-contentbf34a89e-c1a7-4e2a-b74a-5db80bdeeb23" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/corporate-governance" class="sf-depth-2 sf-external">Corporate Governance</a></li><li id="mobile-main-menu-menu-link-content25975bd7-8f66-45d8-ac81-95efe8702691" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/analyst-coverage" class="sf-depth-2 sf-external">Analyst Coverage</a></li><li id="mobile-main-menu-menu-link-contente1a1245c-2631-41e6-81f8-6b63342f21f8" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/financial-statements" class="sf-depth-2 sf-external">Fundamentals</a></li><li id="mobile-main-menu-menu-link-content5e15851f-7957-41c0-be0d-728e1623c285" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/ownership-profile" class="sf-depth-2 sf-external">Ownership Profile</a></li><li id="mobile-main-menu-menu-link-content00f215d0-3d55-474b-9ded-f4c9402bfe70" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/annual-meetings" class="sf-depth-2 sf-external">Annual Meetings</a></li><li id="mobile-main-menu-menu-link-contentd3a6f148-04f6-4fa4-a4ea-c5c4fbf68583" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/press-releases" class="sf-depth-2 sf-external">Press Releases</a></li><li id="mobile-main-menu-menu-link-contente783ea22-3a21-4a31-ba98-319cd93575bd" class="sf-depth-2 sf-no-children"><a href="https://capella.alnylam.com/our-science/capella-rnai-innovation/" class="sf-depth-2 sf-external">Capella (Scientific Presentations)</a></li><li id="mobile-main-menu-menu-link-content14ba81c4-1a33-474e-b5b6-442293872f36" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/faq" class="sf-depth-2 sf-external">FAQs</a></li></ul></li><li id="mobile-main-menu-menu-link-content906448e2-f167-4cb5-b599-a9c82258af65" class="sf-depth-1 menuparent"><span class="medical-professionals sf-depth-1 menuparent nolink">Medical Professionals</span><ul><li id="mobile-main-menu-menu-link-content8ff0ac61-9365-4da7-b6d2-72faedf726c6" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources" class="sf-depth-2">For Medical Professionals</a></li><li id="mobile-main-menu-menu-link-content75eab371-f4c0-4d8d-b708-4ce7f0684a83" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources/genetic-testing-counseling" class="sf-depth-2">Genetic Testing & Counseling</a></li><li id="mobile-main-menu-menu-link-content3c549964-6def-42ef-a42e-251434317abd" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources/early-access-program" class="sf-depth-2">Early Access Program</a></li><li id="mobile-main-menu-menu-link-contentb94d932b-35ba-4e21-86a1-408d4bacaa62" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources/early-access-program/patisiran" class="our-science bullet-point sf-depth-2 sf-depth-2">Patisiran Early Access</a></li><li id="mobile-main-menu-menu-link-content11bed8ae-2f2e-41ce-a6a9-f2283babba00" class="sf-depth-2 sf-no-children"><a href="/medical-publication-support" class="sf-depth-2">Medical Publication Support</a></li><li id="mobile-main-menu-menu-link-contentbfb3ae05-e864-4ad6-aca2-1a7197a63860" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/investigator-initiated-studies" class="sf-depth-2">Investigator Initiated Studies (IIS)</a></li></ul></li><li id="mobile-main-menu-menu-link-contented982836-a197-455a-9fda-574503a1f362" class="sf-depth-1 menuparent"><span class="patients sf-depth-1 menuparent nolink">Patients</span><ul><li id="mobile-main-menu-menu-link-contentc9ea7b10-6e86-4fdd-b927-6f58bc4468c6" class="sf-depth-2 sf-no-children"><a href="/patients" class="sf-depth-2">For Patients</a></li><li id="mobile-main-menu-menu-link-content01045309-eed6-4435-b704-74147465f38e" class="sf-depth-2 sf-no-children"><a href="/patients/amyloidosis" class="sf-depth-2">Amyloidosis</a></li><li id="mobile-main-menu-menu-link-content94273325-8005-4ba9-b260-63cb7090050d" class="sf-depth-2 sf-no-children"><a href="/patients/porphyria" class="sf-depth-2">Acute Hepatic Porphyria</a></li><li id="mobile-main-menu-menu-link-contentfd77c281-d9fc-4d9e-a6d1-d0c2ff7342bc" class="sf-depth-2 sf-no-children"><a href="/patients/primary-hyperoxaluria" class="sf-depth-2">Primary Hyperoxaluria</a></li><li id="mobile-main-menu-menu-link-contentc4e83cc5-7a6c-4344-968a-fdb7521a7aa5" class="sf-depth-2 sf-no-children"><a href="/patients/patient-services" class="sf-depth-2">Patient Services</a></li><li id="mobile-main-menu-menu-link-content6da39404-d186-4dbc-a128-5259705d8f3e" class="sf-depth-2 sf-no-children"><a href="/patients/genetic-testing-and-counseling-program" class="sf-depth-2">Genetic Testing and Counseling</a></li><li id="mobile-main-menu-menu-link-content146dea73-fe73-41fb-84a9-2ec2ea763459" class="sf-depth-2 sf-no-children"><a href="/patients/patient-advocacy" class="sf-depth-2">Patient Advocacy</a></li></ul></li><li id="mobile-main-menu-menu-link-contentaa6af9e5-0676-4086-aa75-705491757e77" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Job Seekers</span><ul><li id="mobile-main-menu-menu-link-contentdc51b34c-4683-46b0-8ce1-d7bd3df9731c" class="sf-depth-2 sf-no-children"><a href="/careers" class="sf-depth-2">Careers</a></li><li id="mobile-main-menu-menu-link-contentc0264ced-304c-4173-adad-d79f838e87c3" class="sf-depth-2 sf-no-children"><a href="/careers/working-at-alnylam" class="sf-depth-2">Working at Alnylam</a></li><li id="mobile-main-menu-menu-link-content79731843-7c0e-4027-857f-438feae903c3" class="sf-depth-2 sf-no-children"><a href="/careers/who-we-are" class="sf-depth-2">Who We Are</a></li><li id="mobile-main-menu-menu-link-content39047e9b-a716-471f-b7aa-fe9557564e21" class="sf-depth-2 sf-no-children"><a href="/careers/opportunities" class="sf-depth-2">Career Opportunities</a></li><li id="mobile-main-menu-menu-link-content9406752a-fbb8-4dc0-bb3e-eaad706d2e95" class="sf-depth-2 sf-no-children"><a href="https://jobs.alnylam.com/careers" class="our-science bullet-point sf-depth-2 sf-depth-2 sf-external sf-depth-2 sf-external">Search Jobs</a></li><li id="mobile-main-menu-menu-link-contentca342ef8-4bfc-4311-8e63-9196cddbba5f" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/diversity-inclusion" class="sf-depth-2">Diversity, Equity & Inclusion</a></li></ul></li><li id="mobile-main-menu-menu-link-content6ba287a9-37f6-45c6-924d-2985c62cf323" class="sf-depth-1 menuparent"><span class="quick-links sf-depth-1 menuparent nolink">Quick Links</span><ul><li id="mobile-main-menu-menu-link-content0675b4ae-231d-4429-9d2b-d52fbf4a78dc" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline/clinical-trials" class="sf-depth-2">Clinical Trials</a></li><li id="mobile-main-menu-menu-link-content9fc493db-d879-4db6-9f01-0ea7a445ba15" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/corporate-responsibility" class="sf-depth-2">Corporate Responsibility</a></li><li id="mobile-main-menu-menu-link-content2349be8e-3924-4327-95cd-599c456be6f5" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/diversity-inclusion" class="sf-depth-2">Diversity, Equity & Inclusion</a></li><li id="mobile-main-menu-menu-link-content369c2613-4f95-495f-b97d-7fe7704c1281" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/press-releases" class="sf-depth-2 sf-external">Press Releases</a></li><li id="mobile-main-menu-menu-link-content9624843b-3ef8-4260-97fc-4719352453f5" class="sf-depth-2 sf-no-children"><a href="https://capella.alnylam.com/our-science/capella-rnai-innovation/" class="sf-depth-2 sf-external">Capella (Scientific Presentations)</a></li><li id="mobile-main-menu-menu-link-content8852cdce-87dc-4c88-be02-219bdc7a435f" class="sf-depth-2 sf-no-children"><a href="https://www.rnaiscience.com/" class="sf-depth-2 sf-external" target="_blank">Medical Resources (RNAi Science)</a></li><li id="mobile-main-menu-menu-link-content54fe53ea-8cc4-4734-9e8b-b9e23b3774a0" class="sf-depth-2 sf-no-children"><a href="/contact-us" class="sf-depth-2">Contact Us</a></li></ul></li> </ul> </section> </div> </div> <div class="mobile-header-logo"> <div class="region region-mobile-logo"> <a class="logo navbar-btn pull-left" href="/" title="Home" rel="home"> <img src="/themes/custom/alnylam/logo.svg" alt="Home" /> </a> </div> </div> <div class="mobile-header-search"> <div class="region region-mobile-search"> <section id="block-basicsearchblock-2" class="block block-alnylam-search block-basic-search-block clearfix"> <div class="alnylam__basic-search-block"> <form action="/search-results" method="GET"> <div class="search-input input-group hide"> <input type="text" name="keyword" placeholder="Type something"/> <button type="submit">search</button> </div> <button type="button" class="search-open-btn"><img src="/modules/custom/alnylam_search/images/search-icon.png"></button> <button type="button" class="search-close-btn hide"><img src="/modules/custom/alnylam_search/images/search-close-icon.png"></button> </form> </div> </section> <section class="views-exposed-form block block-views block-views-exposed-filter-blocksearch-content-page-1 clearfix" data-drupal-selector="views-exposed-form-search-content-page-1" id="block-exposedformsearch-contentpage-1"> <form action="/search-content" method="get" id="views-exposed-form-search-content-page-1" accept-charset="UTF-8"> <div class="form--inline form-inline clearfix"> <div class="form-item js-form-item form-type-textfield js-form-type-textfield form-item-keyword js-form-item-keyword form-no-label form-group"> <input placeholder="Type something" data-drupal-selector="edit-keyword" class="form-text form-control" type="text" id="edit-keyword" name="keyword" value="" size="30" maxlength="128" /> </div> <div class="form-item js-form-item form-type-select js-form-type-select form-item-sort-by js-form-item-sort-by form-group"> <label for="edit-sort-by" class="control-label">Sort by</label> <div class="select-wrapper"><select data-drupal-selector="edit-sort-by" class="form-select form-control" id="edit-sort-by" name="sort_by"><option value="sort_by" selected="selected">Sort By:</option></select></div> </div> <div class="form-item js-form-item form-type-select js-form-type-select form-item-sort-order js-form-item-sort-order form-group"> <label for="edit-sort-order" class="control-label">Order</label> <div class="select-wrapper"><select data-drupal-selector="edit-sort-order" class="form-select form-control" id="edit-sort-order" name="sort_order"><option value="ASC">Sort by: Most Recent</option><option value="DESC" selected="selected">Sort by: Oldest</option></select></div> </div> <div data-drupal-selector="edit-actions" class="form-actions form-group js-form-wrapper form-wrapper" id="edit-actions"><button data-drupal-selector="edit-submit-search-content" class="button js-form-submit form-submit btn-primary btn icon-before" type="submit" id="edit-submit-search-content" value="Search" name=""><span class="icon glyphicon glyphicon-search" aria-hidden="true"></span> Search</button></div> </div> </form> </section> <section id="block-language-2" class="block block-block-content block-block-content5a7dc698-6efe-4c02-a3cd-adb2377d4faf clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="language block" id="language-switcher-icon">language<i class="fas fa-angle-down"></i></div> </div> </section> <section id="block-languageswitcher-2" class="block block-block-content block-block-content4a663d92-67bc-4ad7-997c-8ad8f4f6a3aa clearfix"> <div class="field field--name-field-language-link field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--107 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Global</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--108 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Austria</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-austria">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--124 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Japan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.jp/">日本語</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--110 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Belgium</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-belgium-dutch"> Nederlands</a></div> <div class="field--item"><a href="/alnylam-belgium-french">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--109 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Luxembourg</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-luxembourg-french">Français</a></div> <div class="field--item"><a href="/alnylam-luxembourg-german"> Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--112 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Brazil </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.com.br/">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--111 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Netherlands </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-netherlands">Nederlands</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--114 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Canada </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français </a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--113 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Portugal</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-portugal">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1513 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Czech Republic</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-czech-republic">Čeština</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--115 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Spain </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-espana">Español</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--116 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Denmark </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-denmark">Dansk</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--117 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Sweden</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-sverige">Svenska</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--118 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">France</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.fr/">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--119 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Switzerland</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-switzerland-french">Français</a></div> <div class="field--item"><a href="/alnylam-switzerland-german">Deutsch</a></div> <div class="field--item"><a href="/alnylam-switzerland-italian">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--120 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Germany </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.de/">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--121 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Taiwan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-taiwan">繁體中文</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1514 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Ireland </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-ireland">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--123 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">United Kingdom</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--122 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italy</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> <div id="whole-header-top" class="container-fluid"> <div class="header-top-left col-sm-2"> <div class="region region-header-top-left"> <a class="logo navbar-btn pull-left" href="/" title="Home" rel="home"> <img src="/themes/custom/alnylam/logo.svg" alt="Home" /> </a> </div> </div> <div class="header-top-middle col-sm-9"> <div class="region region-header-top-middle"> <section id="block-alnylam-topnavigation-3" class="block block-superfish block-superfishtop-navigation clearfix"> <ul id="superfish-top-navigation" class="menu sf-menu sf-top-navigation sf-horizontal sf-style-none"> <li id="top-navigation-menu-link-content64f38306-897f-4a7c-99eb-affe953acf01" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Investors</span><ul><li id="top-navigation-menu-link-content0099a821-634f-457b-bfed-bba6d6235d4f" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/" class="sf-depth-2 sf-external">For Investors</a></li><li id="top-navigation-menu-link-contente1e1fcab-d6cb-4681-aec8-647dac1fe8f2" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/alny-stock-information" class="sf-depth-2 sf-external">Stock Information</a></li><li id="top-navigation-menu-link-content37980c4c-fa7d-430a-9bb6-13addbb93796" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/investor-toolkit" class="sf-depth-2 sf-external">Investors Toolkit</a></li><li id="top-navigation-menu-link-content8f5bcff2-d5da-45e2-b6df-8bb846a4edc4" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/events" class="sf-depth-2 sf-external">Events & Presentations</a></li><li id="top-navigation-menu-link-content1cbbc9bd-ff86-41f1-b059-9004baaceb84" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/financial-information" class="sf-depth-2 sf-external">Financial Information</a></li><li id="top-navigation-menu-link-content7a928654-3535-49aa-a4db-ba6e25e4c2a4" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/financial-information?sec=#sec_filings" class="sf-depth-2 sf-external">SEC Filings</a></li><li id="top-navigation-menu-link-contentdc6a6762-e16f-4dbe-97a8-d241f845ee67" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/corporate-governance" class="sf-depth-2 sf-external">Corporate Governance</a></li><li id="top-navigation-menu-link-contente6160938-8183-409f-a295-bf7b1e63e2a2" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/analyst-coverage" class="sf-depth-2 sf-external">Analyst Coverage</a></li><li id="top-navigation-menu-link-contentedddf916-b737-47ab-aa6a-71253e61bc28" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/financial-statements" class="sf-depth-2 sf-external">Fundamentals</a></li><li id="top-navigation-menu-link-content23cfb6f5-0d25-4522-a3fa-9d440596dfb3" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/ownership-profile" class="sf-depth-2 sf-external">Ownership Profile</a></li><li id="top-navigation-menu-link-content4f9e088d-affc-4b7f-b98a-6c1f7ddf1592" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/annual-meetings" class="sf-depth-2 sf-external">Annual Meetings</a></li><li id="top-navigation-menu-link-content93231329-f098-4532-a066-a1cf9788e312" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/press-releases" class="sf-depth-2 sf-external">Press Releases</a></li><li id="top-navigation-menu-link-contentffd6b8ff-a8cc-4063-8dac-12013701ae47" class="sf-depth-2 sf-no-children"><a href="/our-science/capella-rnai-innovation/" class="sf-depth-2">Capella (Scientific Presentations)</a></li><li id="top-navigation-menu-link-content8de59c6c-bc28-4b23-8998-1925785f4b3b" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/faq" class="sf-depth-2 sf-external">FAQs</a></li></ul></li><li id="top-navigation-menu-link-contentb36c196f-2f8e-4310-bc93-e5d878980127" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Medical Professionals</span><ul><li id="top-navigation-menu-link-content1c655bb6-b7e4-4589-be94-485f1cf130ba" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources" class="sf-depth-2">For Medical Professionals</a></li><li id="top-navigation-menu-link-content3000df5e-a317-48c2-8d12-9d35ff18ab84" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources/genetic-testing-counseling" class="sf-depth-2">Genetic Testing & Counseling</a></li><li id="top-navigation-menu-link-contentc1f9e31b-6ba0-42a6-a7cc-bf017093d4fc" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources/early-access-program" class="sf-depth-2">Early Access Program</a></li><li id="top-navigation-menu-link-content0fb71b04-3380-43e5-bfe2-85fa58e84f69" class="sf-depth-2 sf-no-children"><a href="/medical-professional-resources/early-access-program/patisiran" class="our-science bullet-point sf-depth-2 sf-depth-2">Patisiran Early Access</a></li><li id="top-navigation-menu-link-contentb8602123-ea5b-42e6-a698-e5a7cc7ccbfe" class="sf-depth-2 sf-no-children"><a href="/medical-publication-support" class="sf-depth-2">Medical Publication Support</a></li><li id="top-navigation-menu-link-content35f0355d-0b74-4ff4-9312-750a27599d50" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/investigator-initiated-studies" class="sf-depth-2">Investigator Initiated Studies (IIS)</a></li></ul></li><li id="top-navigation-menu-link-content2c648995-20d4-4a54-8514-e596548347a3" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Patients</span><ul><li id="top-navigation-menu-link-content47262aab-cea7-4f48-bda3-892eb77e1fe5" class="sf-depth-2 sf-no-children"><a href="/patients" class="sf-depth-2">For Patients</a></li><li id="top-navigation-menu-link-content2aec25a1-fffc-47c4-afc6-9ecffea4a957" class="sf-depth-2 sf-no-children"><a href="/patients/amyloidosis" class="sf-depth-2">Amyloidosis</a></li><li id="top-navigation-menu-link-content4f367b2f-c763-48c7-8b76-f0dc429c4207" class="sf-depth-2 sf-no-children"><a href="/patients/porphyria" class="sf-depth-2">Acute Hepatic Porphyria</a></li><li id="top-navigation-menu-link-contentd793d1c5-e0d2-4f08-b118-fe5c25138c4a" class="sf-depth-2 sf-no-children"><a href="/patients/primary-hyperoxaluria" class="sf-depth-2">Primary Hyperoxaluria</a></li><li id="top-navigation-menu-link-content69a9bc19-c8bd-441b-a9bc-201e56561aa6" class="sf-depth-2 sf-no-children"><a href="/patients/patient-services" class="sf-depth-2">Patient Services</a></li><li id="top-navigation-menu-link-content0c9b008f-5b6c-4969-a855-569e25e69256" class="sf-depth-2 sf-no-children"><a href="/patients/genetic-testing-and-counseling-program" class="sf-depth-2">Genetic Testing and Counseling</a></li><li id="top-navigation-menu-link-content36301e76-cc52-42f0-840a-fb6aa930051f" class="sf-depth-2 sf-no-children"><a href="/patients/patient-advocacy" class="sf-depth-2">Patient Advocacy</a></li></ul></li><li id="top-navigation-menu-link-content96409c7b-3b98-4591-aa4c-60c096b1757e" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Job Seekers</span><ul><li id="top-navigation-menu-link-contentb8a5d157-460c-4f44-8d99-d624cd918a2f" class="sf-depth-2 sf-no-children"><a href="/careers" class="sf-depth-2">Careers</a></li><li id="top-navigation-menu-link-content9ce32415-4565-4d11-be6a-97b54089cb96" class="sf-depth-2 sf-no-children"><a href="/careers/working-at-alnylam" class="sf-depth-2">Working at Alnylam</a></li><li id="top-navigation-menu-link-contentc129b114-fc84-4b88-9b2c-80d8cd39201b" class="sf-depth-2 sf-no-children"><a href="/careers/who-we-are" class="sf-depth-2">Who We Are</a></li><li id="top-navigation-menu-link-contentaa194a9b-4646-4c04-bcd2-3cd775454f27" class="sf-depth-2 sf-no-children"><a href="/careers/opportunities" class="sf-depth-2">Career Opportunities</a></li><li id="top-navigation-menu-link-contentcfa06c04-2fae-4d7a-9b56-d5b4d5390fe9" class="sf-depth-2 sf-no-children"><a href="https://jobs.alnylam.com/careers" class="our-science bullet-point sf-depth-2 sf-depth-2 sf-external">Search Jobs</a></li><li id="top-navigation-menu-link-content904aff3e-6234-4b0c-a23e-3a6a8b5b2674" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/diversity-inclusion" class="sf-depth-2">Diversity, Equity & Inclusion </a></li></ul></li><li id="top-navigation-menu-link-content0980788b-164c-4cd5-8344-f8ac256dab54" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Quick Links</span><ul><li id="top-navigation-menu-link-contente5b10497-a6bb-41c8-9c32-226abec4f73c" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline/clinical-trials" class="sf-depth-2">Clinical Trials</a></li><li id="top-navigation-menu-link-content5586e07f-c18e-45aa-bf7a-6b1de2786d02" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/corporate-responsibility" class="sf-depth-2">Corporate Responsibility</a></li><li id="top-navigation-menu-link-content803e4ad3-61c9-42e0-97d1-d1a9bbce0b77" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/diversity-inclusion" class="sf-depth-2">Diversity, Equity & Inclusion</a></li><li id="top-navigation-menu-link-content0226dfd4-4752-4faa-bf8c-6b325170cdb9" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/press-releases" class="sf-depth-2 sf-external">Press Releases</a></li><li id="top-navigation-menu-link-content2e003df3-d61a-4c7e-8238-359dd2fe78a1" class="sf-depth-2 sf-no-children"><a href="/our-science/capella-rnai-innovation/" class="sf-depth-2">Capella (Scientific Presentations)</a></li><li id="top-navigation-menu-link-contentc5aeb145-4476-412c-b7a0-33c8941d8abd" class="sf-depth-2 sf-no-children"><a href="https://www.rnaiscience.com/" class="sf-depth-2 sf-external" target="_blank">Medical Resources (RNAi Science)</a></li><li id="top-navigation-menu-link-contenteeee7deb-d1d5-4aad-8ccd-e8931b990153" class="sf-depth-2 sf-no-children"><a href="/contact-us" class="sf-depth-2">Contact Us</a></li></ul></li><li id="top-navigation-menu-link-contentb323995c-f7d7-4b92-97c8-2b7f45bd1238" class="sf-depth-1 menuparent"><span class="sf-depth-1 menuparent nolink">Follow Us</span><ul><li id="top-navigation-menu-link-content0fd2a3b1-6274-4b0f-a0ea-8411d910ae71" class="sf-depth-2 sf-no-children"><a href="https://www.youtube.com/channel/UCUZReY0GSAJ1w-MULQb9_Rw" class="youtube sf-depth-2 sf-external" target="_blank">Youtube</a></li><li id="top-navigation-menu-link-contentedd57f45-7de7-4149-a676-5c4dde84bad5" class="sf-depth-2 sf-no-children"><a href="https://facebook.com/alnylampharma" class="facebook sf-depth-2 sf-external" target="_blank">Facebook</a></li><li id="top-navigation-menu-link-contentbfa3443d-bb70-4c37-92ae-5c17ff981c83" class="sf-depth-2 sf-no-children"><a href="https://twitter.com/alnylam" class="twitter sf-depth-2 sf-external" target="_blank">X</a></li><li id="top-navigation-menu-link-contentd6d243a3-6c5e-43f5-80d2-aabc43bbe67d" class="sf-depth-2 sf-no-children"><a href="https://www.linkedin.com/company/alnylam-pharmaceuticals/" class="linkedin sf-depth-2 sf-external" target="_blank">LinkedIn</a></li><li id="top-navigation-menu-link-contentc4f4f8f8-c7b8-4d4e-a24c-0ba013135e39" class="sf-depth-2 sf-no-children"><a href="https://www.instagram.com/alnylampharma/" class="instagram sf-depth-2 sf-external" target="_blank">Instagram</a></li><li id="top-navigation-menu-link-content75df3d3f-dce4-4177-b1c5-c55a5693b7ef" class="sf-depth-2 sf-no-children"><a href="/signup-for-updates" class="mail sf-depth-2" target="_self">Sign Up</a></li></ul></li> </ul> </section> </div> </div> <div class="header-top-right col-sm-1"> <div class="region region-header-top-right"> <section id="block-language" class="block block-block-content block-block-content5a7dc698-6efe-4c02-a3cd-adb2377d4faf clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><div class="language block" id="language-switcher-icon">language<i class="fas fa-angle-down"></i></div> </div> </section> </div> </div> </div> <div id="whole-header-bottom" class="container-fluid"> <div class="header-bottom-left col-sm-6"> <div class="region region-header-bottom-left"> <section id="block-alnylam-mainnavigation-2" class="block block-superfish block-superfishmain clearfix"> <ul id="superfish-main" class="menu sf-menu sf-main sf-horizontal sf-style-none"> <li id="main-menu-link-content16444554-bc00-4866-8d50-bcd4c1d40137" class="sf-depth-1 menuparent"><span class="our-company-main sf-depth-1 menuparent nolink">Our Company</span><ul><li id="main-menu-link-content71bb768d-2c89-4a16-a30f-c791eed5b4f7" class="sf-depth-2 sf-no-children"><a href="/about-alnylam" class="our-company sf-depth-2">About Alnylam</a></li><li id="main-menu-link-content70351e72-c6c5-43d4-b345-3bb49df5e786" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/alnylam-leadership" class="our-company sf-depth-2">Leadership</a></li><li id="main-menu-link-content8c50a23c-78e4-4889-9fe5-554635aef1ec" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/diversity-inclusion" class="our-company sf-depth-2">Diversity, Equity & Inclusion</a></li><li id="main-menu-link-contentcbeef0d8-528d-4af9-8348-83c33d5265d2" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/patient-access-philosophy" class="our-company sf-depth-2">Patient Access Philosophy</a></li><li id="main-menu-link-content86dc6ab6-a8ce-48ce-afe2-2c654951f4b7" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/corporate-responsibility" class="our-company sf-depth-2">Corporate Responsibility</a></li><li id="main-menu-link-content406b6274-bb81-4a97-a118-d193ac248749" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/transparency" class="our-company bullet-point sf-depth-2">Transparency</a></li><li id="main-menu-link-contentafddbff1-65c3-4f96-9518-ee682c1e7435" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/grants-and-giving" class="our-company sf-depth-2">Grants & Giving</a></li><li id="main-menu-link-contentdd98fbc3-d5d9-47b8-bcb4-6c38815fb804" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/grants-and-giving/advocacy-for-impact-grants" class="our-company bullet-point sf-depth-2">Advocacy for Impact Grants</a></li><li id="main-menu-link-content9680d412-096f-4480-9a9b-7c583a525a14" class="sf-depth-2 sf-no-children"><a href="/about-alnylam/investigator-initiated-studies" class="our-company sf-depth-2">Investigator Initiated Studies (IIS)</a></li></ul></li><li id="main-menu-link-contentab68e41a-a846-4e8e-aaf6-8367257469d5" class="sf-depth-1 menuparent"><span class="our-science-main sf-depth-1 menuparent nolink">Our Science</span><ul><li id="main-menu-link-content513c7576-4fed-4679-949e-4acbd2e8f63b" class="sf-depth-2 sf-no-children"><a href="/our-science/the-science-of-rnai" class="our-science sf-depth-2">The Science of RNAi</a></li><li id="main-menu-link-content3d097c54-868e-42b5-b066-30c47f1daff3" class="sf-depth-2 sf-no-children"><a href="/our-science/sirna-delivery-platforms" class="our-science sf-depth-2">Delivery Platforms</a></li><li id="main-menu-link-content9f7cf51f-2070-43b5-b60e-471c6e7d1bf2" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline" class="our-science sf-depth-2">Therapeutic Areas</a></li><li id="main-menu-link-content5de709d9-decf-49cc-a7bc-775915ced565" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline" class="our-science bullet-point sf-depth-2">Pipeline</a></li><li id="main-menu-link-content2dab5c64-c280-422a-bdf3-fa6e297e0493" class="sf-depth-2 sf-no-children"><a href="/alnylam-rnai-pipeline/clinical-trials" class="our-science bullet-point sf-depth-2">Clinical Trials</a></li><li id="main-menu-link-content4e516816-8cc6-4a5f-b7d0-8a15dbdffa2c" class="sf-depth-2 sf-no-children"><a href="/our-science/alnylam-scientific-advisory-board" class="our-science sf-depth-2">Scientific Advisory Board</a></li><li id="main-menu-link-contenteb5a676d-9e52-40d3-89e9-6e8f1fe245b8" class="sf-depth-2 sf-no-children"><a href="/our-science/intellectual-property" class="our-science sf-depth-2">Intellectual Property</a></li><li id="main-menu-link-contente7c1b927-7fb5-4fd0-82c2-05217ec61417" class="sf-depth-2 sf-no-children"><a href="https://capella.alnylam.com/our-science/capella-rnai-innovation/" class="our-science sf-depth-2 sf-external">Capella (Scientific Presentations)</a></li></ul></li><li id="main-menu-link-contente7c3c9c0-d010-45f3-a113-9b8a701f2c53" class="sf-depth-1 menuparent"><span class="our-products-main sf-depth-1 menuparent nolink">Our Products</span><ul><li id="main-menu-link-content8cee579b-4350-4f80-831e-895e28ab37e4" class="sf-depth-2 sf-no-children"><a href="/our-products" class="our-products sf-depth-2">Product Listing</a></li></ul></li><li id="main-menu-link-contentf1db7367-b7a4-4665-ba0e-52b56bcbe059" class="sf-depth-1 menuparent"><span class="our-news-main sf-depth-1 menuparent nolink">Our News</span><ul><li id="main-menu-link-content25f354e5-7a66-4058-b58f-ccd90894e67a" class="sf-depth-2 sf-no-children"><a href="https://news.alnylam.com" class="our-news sf-depth-2 sf-external">Newsroom</a></li><li id="main-menu-link-content0ab21197-6fc8-4681-8e4e-4c00ccf93d76" class="sf-depth-2 sf-no-children"><a href="https://investors.alnylam.com/press-releases" class="our-news sf-depth-2 sf-external">Press Releases</a></li><li id="main-menu-link-content7f534fee-0f07-49f3-9d3a-104a50b6adad" class="sf-depth-2 sf-no-children"><a href="/our-science/capella-rnai-innovation/" class="our-news sf-depth-2">Capella (Scientific Presentations)</a></li><li id="main-menu-link-content05a96e94-d35a-440e-a308-46cc42a3dd0a" class="sf-depth-2 sf-no-children"><a href="/media-kit" class="our-news sf-depth-2">Media Kit</a></li></ul></li> </ul> </section> </div> </div> <div class="header-bottom-right col-sm-6"> <div class="region region-header-bottom-right"> <section id="block-basicsearchblock" class="block block-alnylam-search block-basic-search-block clearfix"> <div class="alnylam__basic-search-block"> <form action="/search-results" method="GET"> <div class="search-input input-group hide"> <input type="text" name="keyword" placeholder="Type something"/> <button type="submit">search</button> </div> <button type="button" class="search-open-btn"><img src="/modules/custom/alnylam_search/images/search-icon.png"></button> <button type="button" class="search-close-btn hide"><img src="/modules/custom/alnylam_search/images/search-close-icon.png"></button> </form> </div> </section> <section class="views-exposed-form block block-views block-views-exposed-filter-blocksearch-content-page-1 clearfix" data-drupal-selector="views-exposed-form-search-content-page-1" id="block-exposedformsearch-contentpage-1-2"> <form action="/search-content" method="get" id="views-exposed-form-search-content-page-1" accept-charset="UTF-8"> <div class="form--inline form-inline clearfix"> <div class="form-item js-form-item form-type-textfield js-form-type-textfield form-item-keyword js-form-item-keyword form-no-label form-group"> <input placeholder="Type something" data-drupal-selector="edit-keyword" class="form-text form-control" type="text" id="edit-keyword--2" name="keyword" value="" size="30" maxlength="128" /> </div> <div class="form-item js-form-item form-type-select js-form-type-select form-item-sort-by js-form-item-sort-by form-group"> <label for="edit-sort-by--2" class="control-label">Sort by</label> <div class="select-wrapper"><select data-drupal-selector="edit-sort-by" class="form-select form-control" id="edit-sort-by--2" name="sort_by"><option value="sort_by" selected="selected">Sort By:</option></select></div> </div> <div class="form-item js-form-item form-type-select js-form-type-select form-item-sort-order js-form-item-sort-order form-group"> <label for="edit-sort-order--2" class="control-label">Order</label> <div class="select-wrapper"><select data-drupal-selector="edit-sort-order" class="form-select form-control" id="edit-sort-order--2" name="sort_order"><option value="ASC">Sort by: Most Recent</option><option value="DESC" selected="selected">Sort by: Oldest</option></select></div> </div> <div data-drupal-selector="edit-actions" class="form-actions form-group js-form-wrapper form-wrapper" id="edit-actions--2"><button data-drupal-selector="edit-submit-search-content-2" class="button js-form-submit form-submit btn-primary btn icon-before" type="submit" id="edit-submit-search-content--2" value="Search" name=""><span class="icon glyphicon glyphicon-search" aria-hidden="true"></span> Search</button></div> </div> </form> </section> <section id="block-languageswitcher" class="block block-block-content block-block-content4a663d92-67bc-4ad7-997c-8ad8f4f6a3aa clearfix"> <div class="field field--name-field-language-link field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--107 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Global</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--108 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Austria</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-austria">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--124 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Japan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.jp/">日本語</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--110 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Belgium</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-belgium-dutch"> Nederlands</a></div> <div class="field--item"><a href="/alnylam-belgium-french">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--109 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Luxembourg</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-luxembourg-french">Français</a></div> <div class="field--item"><a href="/alnylam-luxembourg-german"> Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--112 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Brazil </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.com.br/">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--111 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Netherlands </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-netherlands">Nederlands</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--114 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Canada </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.ca/fr">Français </a></div> <div class="field--item"><a href="https://www.alnylam.ca/">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--113 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Portugal</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-portugal">Português</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1513 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Czech Republic</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-czech-republic">Čeština</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--115 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Spain </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-espana">Español</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--116 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Denmark </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-denmark">Dansk</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--117 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Sweden</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-sverige">Svenska</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--118 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">France</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.fr/">Français</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--119 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Switzerland</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-switzerland-french">Français</a></div> <div class="field--item"><a href="/alnylam-switzerland-german">Deutsch</a></div> <div class="field--item"><a href="/alnylam-switzerland-italian">Italiano</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--120 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Germany </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.de/">Deutsch</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--121 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Taiwan</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-taiwan">繁體中文</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--1514 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Ireland </div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-ireland">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--123 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">United Kingdom</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="/alnylam-uk">English</a></div> </div> </span> </div> </div> </div> <div class="field--item"> <div class="paragraph paragraph--type--language-links paragraph-id--122 paragraph--view-mode--default"> <div class="language-switcher-main"> <span class="label-text"> <div class="field field--name-field-label field--type-string field--label-hidden field--item">Italy</div> </span><span class="link-text"> <div class="field field--name-field-link1 field--type-link field--label-hidden field--items"> <div class="field--item"><a href="https://www.alnylam.it/">Italiano</a></div> </div> </span> </div> </div> </div> </div> </section> </div> </div> </div> </div> </header> <div id="maindiv" class="container-fluid"> <main id="midcontent-area" class="column main-content"> <div id="content"> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <article data-history-node-id="56" role="article" about="/404-not-found" typeof="schema:WebPage" class="page full clearfix"> <span property="schema:name" content="404 not found" class="hidden"></span> <div class="content"> <div class="field field--name-field-add-section field--type-entity-reference-revisions field--label-hidden field--items"> <div class="field--item"> <div class="paragraph paragraph--type--banner-overlay-html-content paragraph-id--306 paragraph--view-mode--default"> <div class="banner-overlay-html-content-description--component " style="width:1132px; margin:auto;"> <div class="field field--name-field-body field--type-text-with-summary field--label-hidden field--item"><div class="page_not_found" style="padding-top: 50px;"> <h2 style="text-align: center;">The page you are looking for is not found</h2> <p class="alternate" style="text-align: center;">The page you are looking for does not exist. It may have been moved, or removed altogether. Perhaps you can return back to the site’s homepage and see if you can find what you are looking for.</p> <div class="separator transparent center " style="margin-top: 35px; text-align: center;"> </div> <p style="text-align: center;"><a class="custom_btn_al" href="/">Back to homepage</a></p> <p> </p> </div> </div> </div> </div> </div> </div> </div> </article> <section id="block-interstitialmodal" class="block block-block-content block-block-content91077066-95c8-4915-8931-1413e257836b clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><!-- Start Interstitial Modal --> <div class="modal" id="inter-modal" role="dialog" tabindex="-1"> <div class="inner" role="document"> <button aria-label="Close" class="close" data-dismiss="modal" type="button"></button> <div class="content"> <div class="title">You are now leaving Alnylam.com</div> <p>The following content may not be associated with Alnylam Pharmaceuticals.</p> <p>Links to all outside sites are provided as a reference for our visitors.</p> <p>Alnylam Pharmaceuticals does not endorse and is not responsible for the content on sites that are not owned and operated by Alnylam Pharmaceuticals.</p> <a class="confirm button-more" href="">Proceed to Site</a> </div> </div></div></div> </section> <section id="block-newtopfooter" class="block block-block-content block-block-content930ef10f-62f3-4817-9fc8-4b0698cb5538 clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><section class="new-footer"><div class="top-dna-lines"> <div class="footer-dna-lines"> <div class="footer-container"> <div class="d-flex"> <div> <h2 class="footer-header">FOLLOW US</h2> <p class="footer-description">Visit our social channels to learn more about the innovative work we are doing at Alnylam.</p> </div> <div class="right-icons d-flex"><a class="js-inter-modal" href="https://www.youtube.com/channel/UCUZReY0GSAJ1w-MULQb9_Rw" target="_blank"><img loading="eager" src="/sites/default/files/inline-images/youtube_icon.svg" /></a> <a class="js-inter-modal" href="https://www.facebook.com/AlnylamPharma/" target="_blank"><img loading="eager" src="/sites/default/files/inline-images/fb_icon.svg" /></a> <a class="js-inter-modal" href="https://twitter.com/alnylam" target="_blank"><img loading="eager" src="/sites/default/files/inline-images/x_icon.svg" /></a> <a class="js-inter-modal" href="https://www.linkedin.com/company/alnylam-pharmaceuticals/" target="_blank"><img loading="eager" src="/sites/default/files/inline-images/linkedin_icon.svg" /></a> <a class="js-inter-modal" href="https://www.instagram.com/alnylampharma/" target="_blank"><img loading="eager" src="/sites/default/files/inline-images/instagram_icon.svg" /></a></div> </div> </div> </div> </div> </section></div> </section> </div> </div> </main> </div> <footer> <div id="whole-footer-top" class="container-fluid"> <div class="footer-top"> <div class="row"> <div class="footer-top-column-1 col-sm-3"> <div class="region region-footer-top-column-first"> <nav role="navigation" aria-labelledby="block-footerfirst-menu" id="block-footerfirst"> <h2 class="visually-hidden" id="block-footerfirst-menu">Footer First</h2> <ul class="menu menu--footer-first nav"> <li class="first"> <a href="/index.php/about-alnylam" data-drupal-link-system-path="node/37">Our Company</a> </li> <li> <a href="/index.php/our-science/the-science-of-rnai" data-drupal-link-system-path="node/48">Our Science</a> </li> <li> <a href="/index.php/our-products" data-drupal-link-system-path="node/50">Our Products</a> </li> <li class="last"> <a href="https://news.alnylam.com/">Our News</a> </li> </ul> </nav> <nav role="navigation" aria-labelledby="block-footermenu-menu" id="block-footermenu"> <h2 class="visually-hidden" id="block-footermenu-menu">Footer Menu</h2> <ul class="menu menu--footer-menu nav"> <li class="first"> <a href="/privacy">Privacy Policy</a> </li> <li> <a href="/sitemap" data-drupal-link-system-path="node/834">Site Map</a> </li> <li> <a href="/legal">Legal Notice</a> </li> <li class="last"> <a href="/signup-for-updates" data-drupal-link-system-path="node/307">Sign Up For Updates</a> </li> </ul> </nav> </div> </div> <div class="footer-top-column-2 col-sm-3"> <div class="region region-footer-top-column-second"> <nav role="navigation" aria-labelledby="block-footersecond-menu" id="block-footersecond"> <h2 class="visually-hidden" id="block-footersecond-menu">Footer Second</h2> <ul class="menu menu--footer-second nav"> <li class="first"> <a href="https://investors.alnylam.com/">Investors</a> </li> <li> <a href="/index.php/medical-professional-resources" data-drupal-link-system-path="node/91">Medical Professionals</a> </li> <li> <a href="/index.php/patients" data-drupal-link-system-path="node/8">Patients</a> </li> <li class="last"> <a href="/index.php/careers" data-drupal-link-system-path="node/2424">Job Seekers</a> </li> </ul> </nav> </div> </div> <div class="footer-top-column-3 col-sm-3"> <div class="region region-footer-top-column-third"> <nav role="navigation" aria-labelledby="block-alnylam-footerthirdmenu-menu" id="block-alnylam-footerthirdmenu"> <h2 class="visually-hidden" id="block-alnylam-footerthirdmenu-menu">Footer third menu</h2> <ul class="menu menu--footer-third-menu nav"> <li class="first"> <a href="/alnylam-rnai-pipeline/clinical-trials" data-drupal-link-system-path="node/467">Clinical Trials</a> </li> <li> <a href="/about-alnylam/corporate-responsibility" data-drupal-link-system-path="node/43">Corporate Responsibility</a> </li> <li> <a href="/about-alnylam/diversity-inclusion" data-drupal-link-system-path="node/3737">Diversity, Equity & Inclusion</a> </li> <li> <a href="https://investors.alnylam.com/press-releases">Press Releases</a> </li> <li> <a href="https://capella.alnylam.com/our-science/capella-rnai-innovation/">Capella</a> </li> <li> <a href="https://www.rnaiscience.com/" target="_blank">Medical Resources (RNAi Science)</a> </li> <li> <a href="/contact-us" data-drupal-link-system-path="node/39">Contact Us</a> </li> <li class="last"> <a href="/signup-for-updates" data-drupal-link-system-path="node/307">Sign Up For Updates</a> </li> </ul> </nav> </div> </div> <div class="footer-top-column-4 col-sm-3"> <div class="region region-footer-top-column-fourth"> <nav role="navigation" aria-labelledby="block-alnylam-footerfouthmenu-menu" id="block-alnylam-footerfouthmenu"> <h2 class="visually-hidden" id="block-alnylam-footerfouthmenu-menu">Footer Fouth Menu</h2> <ul class="menu menu--footer-fouth-menu nav"> <li class="first"> <a href="https://alnylampolicies.com/privacy">Privacy Policy</a> </li> <li> <a href="/index.php/media-kit" data-drupal-link-system-path="node/749">Media Kit</a> </li> <li> <a href="https://alnylampolicies.com/legal">Legal Notice</a> </li> <li class="last"> <a href="/index.php/sitemap" data-drupal-link-system-path="node/834">Site Map</a> </li> </ul> </nav> </div> </div> </div> </div> </div> <div id="whole-footer-bottom" class="container-fluid"> <div class="footer-bottom"> <div class="row"> <div class="footer-bottom-left-area col-sm-6"> <div class="region region-footer-bottom-left"> <section id="block-alnylam-copyright" class="block block-block-content block-block-contentf8a60979-5c77-4924-af65-8a03f756d18b clearfix"> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><p>Copyright © <span class="timer"> </span> Alnylam Pharmaceuticals, Inc. — All Rights Reserved</p> </div> </section> </div> </div> </div> </div> </div> </footer> </div> <script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","scriptPath":null,"pathPrefix":"","currentPath":"","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","suppressDeprecationErrors":true,"blazy":{"loadInvisible":false,"offset":100,"saveViewportOffsetDelay":50,"validateDelay":25,"container":"","loader":true,"unblazy":false},"blazyIo":{"disconnect":false,"rootMargin":"0px","threshold":[0,0.25,0.5,0.75,1]},"slick":{"accessibility":true,"adaptiveHeight":false,"autoplay":false,"pauseOnHover":true,"pauseOnDotsHover":false,"pauseOnFocus":true,"autoplaySpeed":3000,"arrows":true,"downArrow":false,"downArrowTarget":"","downArrowOffset":0,"centerMode":false,"centerPadding":"50px","dots":false,"dotsClass":"slick-dots","draggable":true,"fade":false,"focusOnSelect":false,"infinite":true,"initialSlide":0,"lazyLoad":"ondemand","mouseWheel":false,"randomize":false,"rtl":false,"rows":1,"slidesPerRow":1,"slide":"","slidesToShow":1,"slidesToScroll":1,"speed":500,"swipe":true,"swipeToSlide":false,"edgeFriction":0.35,"touchMove":true,"touchThreshold":5,"useCSS":true,"cssEase":"ease","cssEaseBezier":"","cssEaseOverride":"","useTransform":true,"easing":"linear","variableWidth":false,"vertical":false,"verticalSwiping":false,"waitForAnimate":true},"colorbox":{"opacity":"0.85","current":"{current} of {total}","previous":"\u00ab Prev","next":"Next \u00bb","close":"Close","maxWidth":"98%","maxHeight":"98%","fixed":true,"mobiledetect":true,"mobiledevicewidth":"480px"},"bootstrap":{"forms_has_error_value_toggle":1,"modal_animation":1,"modal_backdrop":"true","modal_focus_input":1,"modal_keyboard":1,"modal_select_text":1,"modal_show":1,"modal_size":"","popover_enabled":1,"popover_animation":1,"popover_auto_close":1,"popover_container":"body","popover_content":"","popover_delay":"0","popover_html":0,"popover_placement":"right","popover_selector":"","popover_title":"","popover_trigger":"click","tooltip_enabled":1,"tooltip_animation":1,"tooltip_container":"body","tooltip_delay":"0","tooltip_html":0,"tooltip_placement":"auto left","tooltip_selector":"","tooltip_trigger":"hover"},"ajaxTrustedUrl":{"\/search-content":true},"superfish":{"superfish-main":{"id":"superfish-main","sf":{"animation":{"opacity":"show","height":"show"},"speed":"fast"},"plugins":{"smallscreen":{"mode":"window_width","accordionButton":"2","title":"Main navigation"},"supposition":true,"supersubs":true}},"superfish-top-navigation":{"id":"superfish-top-navigation","sf":{"animation":{"opacity":"show","height":"show"},"speed":"fast"},"plugins":{"smallscreen":{"mode":"window_width","accordionButton":"2","title":"Top Navigation"},"supposition":true,"supersubs":true}},"superfish-mobile-main-menu":{"id":"superfish-mobile-main-menu","sf":{"animation":{"opacity":"show","height":"show"},"speed":"fast"},"plugins":{"smallscreen":{"mode":"window_width","breakpoint":1006,"accordionButton":"2","title":"Mobile Main navigation"},"supposition":true,"supersubs":true}}},"user":{"uid":0,"permissionsHash":"6540bc09762cfb3bdaa6af6d160fa2246414334a099ee73cac99b8b7146a7aaa"}}</script> <script src="/modules/composer/blazy/js/polyfill/blazy.polyfill.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/polyfill/blazy.classlist.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/polyfill/blazy.promise.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/polyfill/blazy.raf.min.js?snb4hv"></script> <script src="/core/assets/vendor/jquery/jquery.min.js?v=3.6.0"></script> <script src="/core/misc/polyfills/element.matches.js?v=9.4.5"></script> <script src="/core/misc/polyfills/object.assign.js?v=9.4.5"></script> <script src="/core/assets/vendor/underscore/underscore-min.js?v=1.13.3"></script> <script src="/core/assets/vendor/once/once.min.js?v=1.0.1"></script> <script src="/core/assets/vendor/jquery-once/jquery.once.min.js?v=2.2.3"></script> <script src="/core/misc/drupalSettingsLoader.js?v=9.4.5"></script> <script src="/core/misc/drupal.js?v=9.4.5"></script> <script src="/core/misc/drupal.init.js?v=9.4.5"></script> <script src="/core/misc/debounce.js?v=9.4.5"></script> <script src="/modules/composer/blazy/js/dblazy.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/plugin/blazy.dataset.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/plugin/blazy.viewport.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/plugin/blazy.dom.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/plugin/blazy.xlazy.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/plugin/blazy.observer.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/plugin/blazy.loading.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/polyfill/blazy.webp.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/base/blazy.base.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/base/blazy.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/base/io/bio.min.js?snb4hv"></script> <script src="/libraries/easing/jquery.easing.min.js?v=1.3"></script> <script src="/libraries/slick/slick/slick.min.js?v=1.x"></script> <script src="/modules/composer/blazy/js/base/io/bio.media.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/base/blazy.drupal.min.js?snb4hv"></script> <script src="/modules/composer/blazy/js/blazy.load.min.js?snb4hv"></script> <script src="/modules/composer/slick/js/slick.vanilla.min.js?v=9.4.5"></script> <script src="/libraries/colorbox/jquery.colorbox-min.js?v=9.4.5"></script> <script src="/modules/composer/colorbox/js/colorbox.js?v=9.4.5"></script> <script src="/modules/composer/colorbox/styles/default/colorbox_style.js?v=9.4.5"></script> <script src="/modules/composer/colorbox_inline/js/colorbox_inline.js?snb4hv"></script> <script src="/core/misc/jquery.once.bc.js?v=9.4.5"></script> <script src="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/js/bootstrap.js"></script> <script src="/themes/custom/alnylam/js/custom-script.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/nav.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/simple.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/select.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/sliders.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/job-search.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/webform-signup.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/careers.js?snb4hv"></script> <script src="/themes/custom/alnylam/js/timeline.js?snb4hv"></script> <script src="/themes/composer/bootstrap/js/drupal.bootstrap.js?snb4hv"></script> <script src="/themes/composer/bootstrap/js/attributes.js?snb4hv"></script> <script src="/themes/composer/bootstrap/js/theme.js?snb4hv"></script> <script src="/themes/composer/bootstrap/js/popover.js?snb4hv"></script> <script src="/themes/composer/bootstrap/js/tooltip.js?snb4hv"></script> <script src="/modules/custom/alnylam_search/js/alnylam_search.js?v=1"></script> <script src="/libraries/superfish/superfish.js?snb4hv"></script> <script src="/libraries/superfish/jquery.hoverIntent.minified.js?snb4hv"></script> <script src="/libraries/superfish/sfsmallscreen.js?snb4hv"></script> <script src="/libraries/superfish/supposition.js?snb4hv"></script> <script src="/libraries/superfish/supersubs.js?snb4hv"></script> <script src="/modules/composer/superfish/js/superfish.js?v=2.0"></script> <!--//COOKIE OVEN --> <!--//END COOKIE OVEN--> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"NRJS-87ce296e2989ccd0104","applicationID":"580786099","transactionName":"ZQBSZxFRXUIDUBdZW1xKcVAXWVxfTW8nQkFCBFxvDV9XVD5wDF5AQApcXwZCb38NVwZmXVcSc1wNREFeDl8GQg4IE1lWFA==","queueTime":0,"applicationTime":219,"atts":"SUdREVlLTkw=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>