CINXE.COM

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region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div id="node-20225" class="node node-product-sub-category node-promoted page-node- node-type-product-category" about="/rnascope-25-ls-assay-red" typeof="sioc:Item foaf:Document"><div class="nav-tab-container"><ul class="nav nav-tabs page-tabs" id="myTab"><li><a href="/automated-assay-leica">Overview</a></li><li class="pro-category-20224" ><a href="/rnascope-25-ls-assay-brown">RNAscope 2.5 LS Assay-BROWN</a></li><li class="active pro-category-20225"><a href="/rnascope-25-ls-assay-red" class="active">RNAscope 2.5 LS Assay-RED</a></li><li class="pro-category-104792" ><a href="/rnascope-25-ls-duplex-assay">RNAscope 2.5 LS Duplex Assay</a></li><li class="pro-category-480623" ><a href="/rnascope-multiomic-ls-fluorescent-assay">RNAscope™ Multiomic LS Fluorescent Assay</a></li><li class="pro-category-110398" ><a href="/rnascope-ls-multiplex-fluorescent-assay">RNAscope LS Multiplex Fluorescent Assay</a></li><li class="pro-category-138442" ><a href="/rnascope-25-lsx-reagent-kit-brown">RNAscope 2.5 LSx Reagent Kit-BROWN</a></li><li class="pro-category-193472" ><a href="/rnascope-25-lsx-reagent-kit-red-0">RNAscope 2.5 LSx Reagent Kit-RED</a></li><li class="pro-category-246248" ><a href="/basescope-ls-reagent-kit-%E2%80%93-red">BaseScope LS Reagent Kit – RED</a></li><li class="pro-category-425267" ><a href="/mirnascope-ls-reagent-kit-red">miRNAscope LS Reagent Kit Red</a></li><li class="pro-category-464323" ><a href="/rnascopepluslsassay">RNAscopePlusLSAssay</a></li></ul></div><div class="tab-content"><div id="tab0" class="tab-pane fade in active profile"><div class="sample-image"><div class="profile-content"><h3>RNAscope™ 2.5 LS Reagent Kit – RED</h3></div><div class="loader-image-gallery"></div><div id="film_roll" class="sample-slider"><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/LS25Red%20head%26neck%20cancer%20HPV16%2020x_0_0.jpg" width="765" height="451" alt="RNAscope™ 2.5 LS Red - Head & Neck Cancer - HPV16" /><p class="slider-below-text"> RNAscope™ 2.5 LS Red - Head & Neck Cancer - HPV16</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/LS25Red%20kidney%20cancer%20PPIB%2020x_0_0.jpg" width="765" height="451" alt="RNAscope™ 2.5 LS Red - Kidney Cancer - PPIB" /><p class="slider-below-text"> RNAscope™ 2.5 LS Red - Kidney Cancer - PPIB</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/LS25Red%20lung%20cancer%20POLR2A%2040x_0.jpg" width="765" height="451" alt="RNAscope™ 2.5 Red - Lung Cancer - POLR2A" /><p class="slider-below-text"> RNAscope™ 2.5 Red - Lung Cancer - POLR2A</p></div><div><img typeof="foaf:Image" src="https://acdbio.com/sites/default/files/styles/sample_image/public/LS25Red%20prostate%20cancer%20PPIB%2040x_0.jpg" width="765" height="451" alt="RNAscope™ 2.5 LS Red - Prostate Cancer - PPIB" /><p class="slider-below-text"> RNAscope™ 2.5 LS Red - Prostate Cancer - PPIB</p></div></div><style type="text/css"> .loader-image-gallery { position: absolute; left: 0px; top: 0px; width: 100%; height: 100%; z-index: 9999; background: url('/sites/default/files/loading_apple.gif') 50% 35% no-repeat rgb(249,249,249); background-size: 100px; opacity: .8; } .sample-image { position: relative; } </style> <script type="text/javascript"> jQuery(document).ready(function($) { // $('#film_roll').hide(); function preloader(){ $('.loader-image-gallery').hide(); $('#film_roll').show(); } window.onload = preloader; }); </script> <div class="profile-content"> <article class="read-more"><div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><p>The RNAscope 2.5 LS Assay is designed as an automated assay on the Leica Biosystems' BOND RX Research Advanced Staining System. The RNAscope 2.5 LS Assay, is an RNA <em>in situ</em> hybridization assay based on ACD’s patented signal amplification and background suppression technology. The assay uses a novel and proprietary method of<em> in situ</em> hybridization (ISH) to visualize single RNA molecules per cell in a multitude of sample types mounted on slides. RNAscope Assays do not require the RNA-free environment used for traditional ISH.</p><p>The RNAscope 2.5 LS Reagent Kit-RED with it Fast Red dye offers a higher contrast and is the first choice in<em> in situ </em>hybridization applications where chromogenic staining with DAB is less desirable, such as staining of highly pigmented lung, liver, retina and melanoma tissue specimens. Also for genes where a lower expression is assumed, ACD recommends this assay as the red dots clearly distinguish against the hematoxylin staining and are visible under are standard brightfield microscope. </p><p>These new RNAscope 2.5 LS reagents require the new RNAscope 2.5 LS Probes for optimal performance. Probe designs are identical to previous version, however the RNAscope 2.5 LS probes are manufactured for optimal performance with RNAscope 2.5 reagent chemistry.</p></div></div></div> </article></div><div class="profile-bottom"><p>The RNAscope LS Automated Assay workflow requires the following from Leica Biosystems (LeicaBiosystems.com):</p><table><tbody><tr><th>CAT #</th><th>Product Name and Description</th><th>Quantity</th></tr><tr><td>OPT9049</td><td>BOND Titration Kit</td><td>10 containers, 50 inserts</td></tr><tr><td>OP79193</td><td>BOND Open Containers (7 mL)</td><td>10 pack</td></tr><tr><td>OP309700</td><td>BOND Open Containers (30 mL)</td><td>10 pack</td></tr><tr><td>S21.4611</td><td>BOND Universal Covertiles™</td><td>160 pack</td></tr><tr><td>AR9961 & AR9640</td><td>BOND Epitope Retrieval Solution 1 & 2</td><td>1L (RTU) each</td></tr><tr><td>S21.1971</td><td>BOND Mixing Stations</td><td>6 vials</td></tr><tr><td>AR9222</td><td>BOND Dewax Solution</td><td>1L (RTU)</td></tr><tr><td>AR9590</td><td>BOND Wash Solution (10x concentrate)</td><td>1L</td></tr><tr><td>DS9390</td><td>BOND Polymer Refine Detection</td><td>1 kit</td></tr><tr><td>CS9100</td><td>BOND Aspirating Probe Cleaning System</td><td>1 system, 15 cleans</td></tr></tbody></table><p> </p><p>RNAscope 2.5 LS Automated Assay—RED Workflow Requires the following from ACD:</p><ul><li>RNAscope 2.5 LS Target Probes (Catalog or Made-to-Order LS Probes)</li><li>RNAscope 2.5 LS Control Probes (Select species-specific LS positive control probes or packs of probes and LS negative control probes)</li><li>RNAscope Control Slides (optional)</li><li>RNAscope 2.5 Leica Assay Reagent Kit—RED</li></ul><h2>Product Retirement:</h2><p>Effective June 30th 2016, RNAscope 2.0 product line will be discontinued and no longer available as a catalog product. This includes the following: RNAscope 2.0 Brown (Cat No 310033 or 310035), RNAscope 2.0 Red (Cat No 310036 or 310034),RNAscope 2.0 LS Brown (Cat No 321100), RNAscope 2.0 LS Red (Cat No 321130), RNAscope 2.0 VS Brown (Cat No 320600),RNAscope 2.0 VS Red (Cat No 320610).</p><p>Please refer to the <a href="/technical-support/solutions">FAQ</a> for more information about 2.0 discontinuance.</p><p>More information on RNAscope 2.5 can be viewed in the Webinar titled “RNAscope New Product Development- learn more about RNAscope 2.5 product line” <a href="/technical-support/learn-more">here</a></p><div class="shop-products"> <a href="https://acdbio.com/search/site/%252A%252A/cms/product/product-type/automated-assay-25-leica-system">Shop products</a></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $('.nomen-content').hide(); $('.nomen-tabs li').hover(function() { $('.nomen-content').show(); $(this).addClass('active'); $('.nomen-content > 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class="embeddedServiceTitleText" id="snapins_titletext">Need help?</span> <button type="button" id="closeInvite" class="embeddedServiceCloseIcon" aria-label="Exit invitation">×</button> </div> <div class="embeddedServiceInvitationBody"> <p id="snapins_bodytext">How can we help you?</p> </div> <div class="embeddedServiceInvitationFooter" aria-describedby="snapins_bodytext"> <button type="button" class="embeddedServiceActionButton" id="rejectInvite">Close</button> <button type="button" class="embeddedServiceActionButton" id="acceptInvite">Start Chat</button> </div> </div> <style type='text/css'> #snapins_invite { background-color: #FFFFFF; font-family: "Arial", sans-serif; overflow: visible; border-radius: 8px; visibility: hidden; } .embeddedServiceInvitation { background-color: transparent; max-width: 290px; max-height: 210px; -webkit-box-shadow: 0 7px 12px rgba(0,0,0,0.28); -moz-box-shadow: 0 7px 12px rgba(0,0,0,0.28); box-shadow: 0 7px 12px rgba(0,0,0,0.28); } @media only screen and (min-width: 48em) { /*mobile*/ .embeddedServiceInvitation { max-width: 332px; max-height: 210px; } } .embeddedServiceInvitation > .embeddedServiceInvitationHeader { width: inherit; height: 32px; line-height: 32px; padding: 10px; color: #FFFFFF; background-color: #222222; overflow: initial; display: flex; justify-content: space-between; align-items: stretch; border-top-left-radius: 8px; border-top-right-radius: 8px; } .embeddedServiceInvitationHeader #embeddedServiceAvatar { width: 32px; height: 32px; border-radius: 50%; } .embeddedServiceInvitationHeader .embeddedServiceTitleText { font-size: 18px; color: #FFFFFF; overflow: hidden; word-wrap: normal; white-space: nowrap; text-overflow: ellipsis; align-self: stretch; flex-grow: 1; max-width: 100%; margin: 0 12px; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon { border: none; border-radius: 3px; cursor: pointer; position: relative; bottom: 3%; background-color: transparent; width: 32px; height: 32px; font-size: 23px; color: #FFFFFF; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus { outline: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:focus::before { content: " "; position: absolute; top: 11%; left: 7%; width: 85%; height: 85%; background-color: rgba(255, 255, 255, 0.2); border-radius: 4px; pointer-events: none; } .embeddedServiceInvitationHeader .embeddedServiceCloseIcon:active, .embeddedServiceCloseIcon:hover { background-color: #FFFFFF; color: rgba(0,0,0,0.7); opacity: 0.7; } .embeddedServiceInvitation > .embeddedServiceInvitationBody { background-color: #FFFFFF; max-height: 110px; min-width: 260px; margin: 0 8px; font-size: 14px; line-height: 20px; overflow: auto; } .embeddedServiceInvitationBody p { color: #333333; padding: 8px; margin: 12px 0; } .embeddedServiceInvitation > .embeddedServiceInvitationFooter { width: inherit; color: #FFFFFF; text-align: right; background-color: #FFFFFF; padding: 10px; max-height: 50px; border-bottom-left-radius: 8px; border-bottom-right-radius: 8px; } .embeddedServiceInvitationFooter > .embeddedServiceActionButton { font-size: 14px; max-height: 40px; border: none; border-radius: 4px; padding: 10px; margin: 4px; text-align: center; text-decoration: none; display: inline-block; cursor: pointer; } .embeddedServiceInvitationFooter > #acceptInvite { background-color: #005290; color: #FFFFFF; } .embeddedServiceInvitationFooter > #rejectInvite { background-color: #FFFFFF; color: #005290; } </style>   <input type="hidden" name="liveagent.prechat.findorcreate.map.doFind:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.isExactMatch:Contact" value="LastName,true;FirstName,true;Email,true" /> <input type="hidden" name="liveagent.prechat.findorcreate.map.doCreate:Contact" value="LastName,true;FirstName,true;Email,true" /> <script type='text/javascript'> (function() { document.getElementById('closeInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; document.getElementById('rejectInvite').onclick = function() { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }; // use this API call to reject invitations document.getElementById('acceptInvite').onclick = function() { embedded_svc.liveAgentAPI.startChat({ directToButtonRouting: { buttonId: "5733t000000cVk9" }, extraPrechatInfo: [], extraPrechatFormDetails: [] }); }; // use this API call to start chat from invitations document.addEventListener('keyup', function(event) { if (event.keyCode == 27) { embedded_svc.inviteAPI.inviteButton.rejectInvite(); }}) })(); </script>  <script type='text/javascript' src='https://service.force.com/embeddedservice/5.0/esw.min.js'></script> <script type='text/javascript'> var initESW = function(gslbBaseURL) { embedded_svc.settings.displayHelpButton = true; //Or false embedded_svc.settings.language = ''; //For example, enter 'en' or 'en-US' embedded_svc.settings.defaultMinimizedText = 'Chat now'; //(Defaults to Chat with an Expert) embedded_svc.settings.disabledMinimizedText = 'Leave a message'; //(Defaults to Agent Offline) embedded_svc.settings.autoOpenPostChat = true; //embedded_svc.settings.loadingText = ''; //(Defaults to Loading) //embedded_svc.settings.storageDomain = 'yourdomain.com'; //(Sets the domain for your deployment so that visitors can navigate subdomains during a chat session) // Settings for Chat embedded_svc.settings.directToButtonRouting = function (prechatFormData) { if (prechatFormData[4].value === "Technical Service") return "5733t000000XZAM"; if (prechatFormData[4].value === "Customer Care") return "5733t000000XZAH"; }; embedded_svc.settings.prepopulatedPrechatFields = { OmniURL__c: window.location.href, ChooseaDepartment__c: 'Technical Service' }; //Sets the auto-population of pre-chat form fields embedded_svc.settings.extraPrechatFormDetails = [{ "label":"Source Domain", "value":window.location.href, "transcriptFields":[ "Source_Domain__c" ], "displayToAgent":true }]; //embedded_svc.settings.fallbackRouting = []; //An array of button IDs, user IDs, or userId_buttonId embedded_svc.settings.offlineSupportMinimizedText = 'Leave a message'; //(Defaults to Contact Us) embedded_svc.settings.enabledFeatures = ['LiveAgent']; embedded_svc.settings.entryFeature = 'LiveAgent'; embedded_svc.init( 'https://biotechne.my.salesforce.com', 'https://biotechne.my.salesforce-sites.com/LiveAgent', gslbBaseURL, '00D500000006gkl', 'ACD_Chat_Automated', { baseLiveAgentContentURL: 'https://c.la1-c1-ia5.salesforceliveagent.com/content', deploymentId: '572380000004CqL', buttonId: '5733t000000cVk9', baseLiveAgentURL: 'https://d.la1-c1-ia5.salesforceliveagent.com/chat', eswLiveAgentDevName: 'EmbeddedServiceLiveAgent_Parent04I3t000000Y7zbEAC_175bb741b99', isOfflineSupportEnabled: true } ); }; if (!window.embedded_svc) { var s = document.createElement('script'); s.setAttribute('src', 'https://biotechne.my.salesforce.com/embeddedservice/5.0/esw.min.js'); s.onload = function() { initESW(null); }; document.body.appendChild(s); } else { initESW('https://service.force.com'); } </script> <script src="//rum-static.pingdom.net/pa-5c133f6e1872b50016000024.js" async></script> <script type="text/javascript">window.NREUM||(NREUM={});NREUM.info={"beacon":"bam.nr-data.net","licenseKey":"NRJS-dd6144c4de227d09eb4","applicationID":"1022125825","transactionName":"YFxbZkpUXBYEVkYNWVkWbEBRGlsLAVBKSkZfSQ==","queueTime":0,"applicationTime":317,"atts":"TBtYEAJOTxg=","errorBeacon":"bam.nr-data.net","agent":""}</script></body> </html>