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KEGG DRUG: Levomethadyl acetate hydrochloride
<!doctype html> <html><head> <title>KEGG DRUG: Levomethadyl acetate hydrochloride</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1743395883"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1743395883"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1743395883" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; } else{ obj.style.display = 'none'; clk.innerHTML = ' » '+show; } } } function toggleData(bobj,e){ var id = bobj.id.replace(/[^0-9]/g,''); var dt = document.getElementById('kcfd'+id); e.preventDefault(); if(!dt.style.display||dt.style.display == 'none'){ document.getElementById('kcfb'+id).innerHTML = 'Hide'; dt.style.display = 'block'; } else{ document.getElementById('kcfb'+id).innerHTML = 'Show'; dt.style.display = 'none'; } } function btn(bobj,img) { bobj.src = "/Fig/bget/button_" + img + ".gif"; } function btn_e(e) { e = e || event; var obj = e.target; var img = e.target.src; var img_base = img.replace(/\\/g,'/').replace(/(b|bd|bh)\.gif$/,''); if(e.type == 'mousedown'||e.type == 'touchstart'){ obj.src = img_base +'bd.gif'; } else if(e.type == 'mouseover'){ obj.src = img_base +'bh.gif'; } else if(e.type == 'mouseup'||e.type == 'touchend'){ obj.src = img_base +'b.gif'; } else if(e.type == 'mouseout'){ obj.src = img_base +'b.gif'; } } function init(){ for(var i=1;i<=1;i++){ if(document.getElementById('kcfb'+i)){ document.getElementById('kcfb'+i).onclick = function(e){toggleData(this,e);}; } } } function Link_XtrctSeq2(form) { var dna_from; var dna_to; var dna_len; var plus_up = Number(form.XtrctSeq_UP.value) ; var plus_down = Number(form.XtrctSeq_DOWN.value); var vector = Number(form.VECTOR.value); var org = form.ORG.value; var chr = form.CHR.value; var kid = form.KEGGID.value; var url; if (plus_up == 0 && plus_down == 0) { url = "/entry/-f+-n+n+" + kid; } else { if (vector == 1) { dna_from = Number(form.FROM.value) - plus_up; dna_to = Number(form.TO.value) + plus_down; } else { dna_from = Number(form.FROM.value) - plus_down; dna_to = Number(form.TO.value) + plus_up; } url = "/dbget-bin/cut_sequence_genes.pl?FROM=" + dna_from + "&TO=" + dna_to +"&VECTOR=" + vector + "&ORG=" + org; if (chr) url += "&CHR=" + chr; } //window.open( url, "_self" ); location.href = url; } function go_taxonomy(form,params){ for(var key in params){ if(form[key]){ form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="668"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D00840"></a><font class="title5">DRUG: Levomethadyl acetate hydrochloride</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D00840 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Levomethadyl acetate hydrochloride (USAN);<br>Orlaam (TN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td50 defd"><div class="cel">C23H31NO2. HCl<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td51 defd"><div class="cel">389.2122<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td50 defd"><div class="cel">389.96<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td51 defd"><a href="/Fig/drug/D00840.gif"><img name="img0" src="/Fig/drug/D00840.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D00840';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D00840';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D00840&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">Simcomp</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='/kegg-bin/simcomp_list?id=D00840';return false;">Neighbor</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Neuropsychiatric agent<br> <a href="/entry/DG01564">DG01564</a> Opioid receptor agonist<br> <a href="/entry/DG01563">DG01563</a> mu-Opioid receptor agonist<br> Analgesic<br> <a href="/entry/DG01984">DG01984</a> Opioid analgesics<br> Metabolizing enzyme substrate<br> <a href="/entry/DG01633">DG01633</a> CYP3A/CYP3A4 substrate<br> <a href="/entry/DG02913">DG02913</a> CYP3A4 substrate<br> </span></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D00840">N07BC03</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Chemical structure group: </span></td><td><a href="/entry/DG01000">DG01000</a></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td51 defd"><div class="cel">Analgesic (narcotic), Opioid receptor agonist</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td50 defd"><div class="cel">OPRM1 [HSA:<a href="/entry/hsa:4988">4988</a>] [KO:<a href="/entry/K04215">K04215</a>]</div></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td51 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04080+4988">hsa04080</a> </span></td><td>Neuroactive ligand-receptor interaction</td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Metabolism</span></th> <td class="td50 defd"><div class="cel">Enzyme: CYP3A4 [HSA:<a href="/entry/hsa:1576">1576</a>]<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Interaction</span></th> <td class="td51 defd"><div class="cel"><button class="btn" onclick="location.href='/kegg-bin/ddi_list?drug=D00840';return false;">DDI search</button></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Structure map</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map07039+D00840">map07039</a> </span></td><td>Opioid analgesics</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map07224+D00840">map07224</a> </span></td><td>Opioid receptor agonists/antagonists</td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D00840">br08303</a>]<br> N NERVOUS SYSTEM<br> N07 OTHER NERVOUS SYSTEM DRUGS<br> N07B DRUGS USED IN ADDICTIVE DISORDERS<br> N07BC Drugs used in opioid dependence<br> N07BC03 Levacetylmethadol<br> D00840 Levomethadyl acetate hydrochloride (USAN)<br> Drug groups [BR:<a href="/brite/br08330+D00840+DG01564">br08330</a>]<br> Neuropsychiatric agent<br> DG01564 Opioid receptor agonist<br> DG01563 mu-Opioid receptor agonist<br> DG01000 Levacetylmethadol<br> D00840 Levomethadyl acetate hydrochloride<br> Analgesic<br> DG01984 Opioid analgesics<br> DG01000 Levacetylmethadol<br> D00840 Levomethadyl acetate hydrochloride<br> Metabolizing enzyme substrate<br> DG01633 CYP3A/CYP3A4 substrate<br> DG02913 CYP3A4 substrate<br> DG01000 Levacetylmethadol<br> D00840 Levomethadyl acetate hydrochloride<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D00840">br08310</a>]<br> G Protein-coupled receptors<br> Rhodopsin family<br> Opioid<br> OPRM1<br> D00840 Levomethadyl acetate hydrochloride (USAN)<br> Drug metabolizing enzymes and transporters [<a href="/kegg/drug/br08309.html?id=D00840">br08309.html</a>]<br> Drug metabolizing enzymes<br> D00840<br> Drug groups [BR:<a href="/brite/br08330+D00840+DG01564">br08330</a>]<br> Neuropsychiatric agent<br> DG01564 Opioid receptor agonist<br> DG01563 mu-Opioid receptor agonist<br> DG01000 Levacetylmethadol<br> Analgesic<br> DG01984 Opioid analgesics<br> DG01000 Levacetylmethadol<br> Metabolizing enzyme substrate<br> DG01633 CYP3A/CYP3A4 substrate<br> DG02913 CYP3A4 substrate<br> DG01000 Levacetylmethadol<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D00840';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>43033-72-3</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7847905">7847905</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ChEBI: </span></td><td><a href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6442">6442</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">LigandBox: </span></td><td><a href="http://www.mypresto5.com/ligandbox202210/cgi-bin/liginf.cgi?id=D00840&source=KEGG_DRUG">D00840</a></td></tr></table></td></tr> <tr><th class="th51 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td51 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D00840';return false;">All DBs</button></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td50 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 27<br> 1 X Cl 34.4704 -21.9382<br> 2 C8x C 24.5000 -22.8200<br> 3 C8x C 24.5000 -24.1500<br> 4 C8x C 25.6900 -24.8500<br> 5 C8x C 26.8800 -24.1500<br> 6 C8y C 26.8800 -22.8200<br> 7 C8x C 25.6900 -22.1200<br> 8 C8x C 29.2600 -24.1500<br> 9 C8y C 29.2600 -22.8200<br> 10 C1d C 28.0700 -22.1200<br> 11 C8x C 30.3800 -24.8500<br> 12 C8x C 31.5700 -24.1500<br> 13 C8x C 31.5700 -22.8200<br> 14 C8x C 30.3800 -22.1200<br> 15 C1b C 28.0700 -20.7200<br> 16 C1c C 29.2600 -20.0900<br> 17 C1c C 26.0400 -21.0000<br> 18 C1a C 30.3800 -20.7200<br> 19 N1c N 29.2600 -18.6200<br> 20 C1a C 30.3800 -17.9200<br> 21 C1a C 28.0000 -17.9200<br> 22 O7a O 26.0400 -19.6700<br> 23 C1b C 24.8500 -21.7000<br> 24 C1a C 23.7300 -21.0000<br> 25 C7a C 24.8500 -18.9700<br> 26 C1a C 23.6600 -19.6700<br> 27 O6a O 24.8500 -17.5000<br> BOND 27<br> 1 2 3 2<br> 2 3 4 1<br> 3 4 5 2<br> 4 5 6 1<br> 5 6 7 2<br> 6 2 7 1<br> 7 8 9 1<br> 8 9 10 1<br> 9 6 10 1<br> 10 8 11 2<br> 11 11 12 1<br> 12 12 13 2<br> 13 13 14 1<br> 14 9 14 2<br> 15 10 15 1<br> 16 15 16 1<br> 17 10 17 1<br> 18 16 18 1<br> 19 16 19 1 #Up<br> 20 19 20 1<br> 21 19 21 1<br> 22 17 22 1 #Down<br> 23 17 23 1<br> 24 23 24 1<br> 25 22 25 1<br> 26 25 26 1<br> 27 25 27 2<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D00840">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated database retrieval system</div> </body> </html>