<!DOCTYPE HTML PUBLIC "-//W3C//Dtd HTML 4.01 Transitional//EN"> <html> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-9H47X4K6P6"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-9H47X4K6P6'); </script> <link href="/css/style.css" type="text/css" rel="stylesheet">  </head> <div id="header"> <body bgcolor="#ffffff" leftmargin=0 topmargin=0 marginwidth="0" marginheight="0" >  <table width="915" cellpadding=0 cellspacing=0> <tr><td colspan=8 > <table cellpadding=2 cellspacing=0 width="100%" border=0> <TR> <td rowspan=2 colspan=8 valign=middle align="left"> <DIV style=" padding: 5px 5px 5px 5px;vertical-align: middle;"> <DIV style="float:left; display:table-cell; vertical-align: middle; text-align: center; padding: 10px 20px 5px 5px;"> <a href="/" target="_top"><img src="/images/logos/Panther_logo.jpg" ></a> </DIV> <p style="overflow:hidden;font-size:14px">The mission of the PANTHER knowledgebase is to support biomedical and other research by providing<BR> <b>comprehensive information about the evolution of protein-coding gene families</b>, particularly<BR> protein phylogeny, function and genetic variation impacting that function. <a href="/about.jsp">Learn more</a></p> </DIV> </td> </TR> </table> </td> </tr> <TR> <TD align = "left"><div><b>PANTHER19.0 Released. <a href="/news/news20240620.jsp"> Click</a> for more details.</b></div></TD> </TR> <TR><TD> </TD></TR> <TR> <TD colspan=8 bgcolor="#F0F2F5" valign=middle align="left" > <form name="quicksearch" method=GET onSubmit="javascript:submitQuickSearch();"> <input type="hidden" name="searchType" value="basic"> <input type="hidden" name="fieldName" value="all"> <input type="hidden" name="organism" value="all"> <table align="left" border="0" cellspacing="0" cellpadding="0" height="100%"> <tr> <td nowrap height=25><input type="text" name="fieldValue" placeholder="search keyword" size=25 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Orthologs</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD> <TD class="subHeader" align="center">  <A href="/panther/">Family & HMMs</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD> <TD class="subHeader" align="center">  <A href="/pathway/">Pathway</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD> <TD class="subHeader" align="center">  <A href="/panther/ontologies.jsp?">Ontologies</A>  </TD> <TD width=5><img src="/images/header/divider.gif" border="0"></TD>  </TR> </TABLE> </TD> </TR> <TR> <TD height=1 colspan=8 bgcolor="#B8C6D8"><img height=1 src="/images/spacer.gif"></TD> </TR> </table> <table width="915" cellpadding=0 cellspacing=0 width="100%" border=0> <TR> <TD> </TD>   <TD align = "right" class="formLabel"> Current Release: <a href="/news/news20240620.jsp"><b>PANTHER 19.0</a></b>  |  <b><a href="/panther/index.jsp">15,683</a></b> family phylogenetic trees  |  <b><a href="/panther/summaryStats.jsp">144</a></b> species  |  <a href="/news/news20240620.jsp">News</a>  <br><A href="/servlet/GenomeFunctionChartServlet?chartType=1&listType=1&annotType=5&species=Homo sapiens">Whole genome function views</A>   </TD> </TR> </table> </div>   <div id="mainbody"> <div style="width:875px;"> <div class="header1">Ontologies</div> "PANTHER GO-slim" uses a selected set of terms from the <A href="http://www.geneontology.org/">Gene Ontology </A><sup>TM</sup> for classifications by molecular function, biological process and cellular component. The PANTHER Protein Class ontology was adapted from the PANTHER/X molecular function ontology, and includes commonly used classes of protein functions, many of which are not covered by GO molecular function. Download the <A href="http://data.pantherdb.org/PANTHER19.0/ontology/Protein_Class_19.0"> classes </A> and <A href="http://data.pantherdb.org/PANTHER19.0/ontology/Protein_class_relationship">relationship</A> information.<BR><BR> <div style="margin-left: 1em;"> Molecular function is the function that a protein performs on its direct molecular targets; e.g. the insulin receptor has transmembrane receptor tyrosine protein kinase activity (GO:0004714), which means it catalyzes the reaction that adds a phosphate group to a tyrosine in another protein (its target). </div> <BR><BR> <div style="margin-left: 1em;"> Cellular component is the location where the protein performs its molecular function; e.g. the insulin receptor is located in the plasma membrane (GO:0005886). </div> <BR><BR> <div style="margin-left: 1em;"> Biological process covers the biological systems to which a protein contributes; e.g. the insulin receptor is involved in regulation of carbohydrate metabolic process (GO:0006109). </div> <BR><BR> <div style="margin-left: 1em;"> PANTHER uses only a subset of GO terms (“GO slim”) to facilitate browsing. Download the <A href="http://data.pantherdb.org/PANTHER19.0/ontology/PANTHERGOslim.obo">PANTHER GO slim</A>. </div> <BR><BR> The PANTHER database also contains Gene Ontology annotations downloaded directly from the Gene Ontology <A href="http://www.geneontology.org/"> web site</A>. These annotations are updated monthly. <table width=100% cellpadding=5 cellspacing=10 align="center"> <tr> <td colspan=2 align="center"><img src="/images/structure/groove_dn.gif" width=200></td> </tr> <tr> <td valign="top" width=50%><span class="header2"><A href="/panther/prowler.jsp">Browse ontologies and ontology term definitions</A><BR> <span class="mainText">Browse molecular function and biological process terms to retrieve genes and gene products.</span> </A></span></td> </tr> </table> </div> </div>   <div id="footer"> <table width="915" cellpadding="0" cellspacing="0" border="0" width="100%"> <tr> <td align="center"> <span class="legal"> <DIV style=" padding: 0px 5px 0px 5px;text-align:center;vertical-align:middle;"> <a href="/about.jsp">About</a>   |   <a href="/releaseInfo.jsp">Release Information</a>   |   <a href="/feedback.jsp">Contact Us</a>   |   <a href="/systemRequirements.jsp">System Requirements</a>   |   <a href="/terms/privacyPolicy.jsp">Privacy Policy</a>   |   <a href="/terms/disclaimer.jsp">Disclaimer</a>     <a href="http://geneontology.org/" target="_top"><img src="/images/logos/go-logo.mini.png" border=0 style="padding: 0px 5px 0px 5px;vertical-align: middle;border:0px"></a> <a href="https://globalbiodata.org/scientific-activities/global-core-biodata-resources" target="_top"><img src="/images/logos/GCBR-Logo-RGB.svg" border=0 width="94px" height="40px" style="vertical-align: middle;border:0px"></a> </DIV> </span> </td> </TR> <TR> <td align="center"> <span class="legal"> © Copyright 2024 Paul Thomas All Rights Reserved.</span> </td> </TR> </table> <br>  </td></tr></table> <script language="JavaScript" type="text/javascript"> if (null === window.name || undefined === window.name) { window.name="panthermain"; } </script> <script language="JavaScript" type="text/javascript" src="/js/popout_window.js"></script> <script language="JavaScript" type="text/javascript" src="/js/cookie.js"></script> <script language="JavaScript" type="text/javascript" src="/js/pubPantherCommon.js"></script> <script language="JavaScript" type="text/javascript" src="/js/pathway.js"></script> <script language="JavaScript" type="text/javascript" src="/js/quicksearch.js"></script> <script language="JavaScript" type="text/javascript" src="/js/registration.js"></script> <script language="JavaScript" type="text/javascript" src="/js/subscription.js"></script> </div>  </body> </html>

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